Formulation and evaluation of polymeric thin films of zolmitriptan
|
|
- Garry Burns
- 5 years ago
- Views:
Transcription
1 Research Article Formulation and evaluation of polymeric thin films of zolmitriptan Garima Bansal 1,2 *, Vipin Kumar Garg 1, K. K. Jha 2 ABSTRACT Background: A lot of work had been done in recent years in the development of oral thin films (OTFs) for drug delivery. Triptans, which are highly selective serotonin agonist used for migraine therapy, were used as a model drug for developing novel thin film drug delivery platform. Aim of the present work was to exploit the combination of hydrophilic polymer and β-cyclodextrin to formulated fast dissolving OTF of Zolmitriptan. Method: A total of nine batches of the thin films with different concentration of hydrophilic Methocel E5(HPMC E5) and β-cyclodextrin reportedly having taste-masking and bioenhancing effect were prepared using glycerin as plasticizer. The mechanical properties such as folding endurance, elongation, and tensile strength along with disintegration time were evaluated. Result and conclusion: In vitro dissolution studies carried out in simulated saliva and gastric fluid indicated that more than 80% of the drug was released in <10 min. A compromise was reached between moderate tensile strength and minimum disintegration time as both in vitro disintegration time and tensile strength of film increased with increase in the concentration of polymer. Thus, it was concluded that the one can successfully formulate novel thin film drug delivery system for triptans using a combination of Methocel E5 and β cyclodextrin. KEY WORDS: β-cyclodextrin, Methocel E5, Thin films, Triptans INTRODUCTION According to the classification of headaches published by the International Headache Society in 2004, triptans are therapeutically effective for the treatment of migraine with or without aura. Migraine is one of ten most debilitating pain in the world which can last for the duration of hours to days and is often associated with nausea, vomiting, etc. Triptans were proved to be highly selective agonist, especially at the serotonin 5-HT1B and 5-HT1D receptor subtypes. Both zolmitriptan and rizatriptan benzoate are available in the market as swallowable tablets, orally disintegrating tablets, and nasal spray. [1,2] Although effective, some drawbacks are associated with triptan therapy like faster onset and longer duration of action was needed for migraine therapy than provided by triptans. Zolmitriptan has short biological half-life and only 40% bioavailability. [3] Furthermore, the swallowing of tablets can stimulate gastric reflex of gastrointestinal tract, worsening the Access this article online Website: jprsolutions.info ISSN: nausea, and vomiting condition associated with a migraine. Thin films have become an attractive alternative to deliver medicines that are usually available as liquids, tablets, or capsules. Furthermore, oral thin films (OTFs) offer faster onset of action, better bioavailability and patient compliance than conventional drug delivery systems. Thus, we can exploit the feature of thin film drug delivery system for overcoming the drawbacks associated with the conventional triptan therapy of migraine. In the present work, fast dissolving thin films of zolmitriptan were developed using a hydrophilic polymer and cyclodextrin. MATERIAL AND METHOD Zolmitriptan was purchased from Jubilant life sciences Ltd. (Noida, India), hydroxypropyl methylcellulose (HPMC 5 cps) Methocel E5 PREM LV was obtained from Dow Chemicals (Mumbai, India), Himedia laboratory Pvt. Ltd (Mumbai), glycerol and sodium saccharin from CDH Laboratories (New Delhi, India). All other chemicals and solvents used were of pharmaceutical and analytical grade. 1 Department of Pharmaceutical Technology, Meerut Institute of Engineering and Technology, Meerut, Uttar Pradesh, India, 2 College of Pharmacy, Teerthankar Mahaveer University, Moradabad, Uttar Pradesh, India *Corresponding author: Garima Bansal, Teerthanker Mahaveer College of Pharmacy, Teerthanker Mahaveer University, Moradabad, Uttar Pradesh, India garimagarg2000@hotmail.com Received on: ; Revised on: ; Accepted on: Journal of Pharmacy Research Vol 12 Issue
2 Formulation Design and Procedure On the basis of literature review, preliminary studies were carried out using different hydrophilic polymers for thin film casting, [4,5] and HPMC E5 was selected as the most suitable film former in combination with cyclodextrin. [6] The composition of the film was given in Table 1. Evaluation of the Drug-loaded Thin Films The physical appearance was observed visually, and the thickness was measured using digital micrometer (Mitutoyo, Japan). Weight uniformity For determining the weight uniformity, five different sections of (2 2) cm 2 films from each batch were cut and weighed individually using electronic balance, and standard deviation (SD) for each batch was determined. Drug content For determination of drug content, 2 2 cm 2 film from each batch was kept in 10 ml phosphate buffer ph 6.8 for 24 h. Then, the solution was filtered, and drug content was determined using (Pharmaspec-1700S, Shimadzu, Japan) ultraviolet spectrophotometer. Three readings from each batch were taken. Average and SD for each batch were calculated. Surface ph Agar plates were prepared by dissolving 2% w/v of agar in a warm isotonic PBS (ph6.2) and then allowed to solidify in a Petri dish. The oral films were cut into smaller pieces (2 2 cm 2 ) kept over the surface of the prepared plate to swell. The surface ph was measured by means of a ph meter (Systronic, India) placed in contact with the swollen film. The average value and SD of three readings were calculated. Determination of percentage moisture absorption [7] The percentage moisture absorption test was carried out to ascertain the physical stability of the oral films during highly humid conditions. In the present study, the moisture absorption capacity of the films was determined as follows. Three 2 2 cm 2 films were cut out and weighed accurately, then the films were placed in desiccator containing saturated solution of aluminum chloride, keeping the humidity inside the desiccators at 80% RH after 3 days, the films were removed and weighed, and percentage moisture absorption was calculated. Average percentage moisture absorption of three films was calculated. Percentage moisture absorption = final weight initial weight 100 Initial weight Determination of percentage moisture loss (PML)[7] Impact of dry conditions on the integrity of the hydrophilic polymeric films can be studied by PML studies. The three films (2 2 cm 2 ) were weighed initially and then placed in a desiccators having fused anhydrous CaCl 2 in the chamber for 3 days. Then, the films were removed from the desiccator and weighed again to calculate the PML by the films using the following formula: Percentage moisture loss = Initial weight-final weight 100 Initial weight Folding endurance The number of times a thin film can be folded at the same plane at 180 without being broken indicates its folding endurance. An average of three observations was taken. Tensile strength The tensile strength of the film was calculated by determining the maximum force applied at the point of rupture of the film divided by its cross-sectional area. Tensile strength = Force at break/initial cross-sectional area of film Percent elongation When stress was exerted on a polymeric film, it tends to stretch out which is called as strain. It can be computed by determining the change in the length of the specimen of the film and dividing it by initial length of the film without any externally applied stress. It was determined by the following formula: Percent elongation = (change in length/initial length) 100 Table 1: Composition of fast dissolving OTFs of zolmitriptan Ingredients (mg) Z1 Z2 Z3 Z4 Z5 Z6 Z7 Z8 Z9 HPMC Zolmitriptan β cyclodextrin Glycerin Saccharine sodium Tween Citric acid Distilled water q.s HPMC: Hydroxypropyl methylcellulose, Journal of Pharmacy Research Vol 12 Issue
3 Both the abovementioned mechanical properties of polymeric fast dissolving OTFs were evaluated by microtensile tester (Instron Microtensile Tester 5848, Singapore) with a 5 kg load cell. A film of 6 2 cm 2 dimension without any visible imperfections was held between two clamps in a vertical position with a distance of 3 cm in between. The cutting of the films due to metallic clamps was avoided fixing a piece of cardboard on the surface with the help of a tape. The film strip was pulled at the rate of 2 mm/s toward upper side till it breaks. In vitro disintegration test [8] In vitro disintegration test was conducted to ascertain the disintegration of OTF. The samples of film were placed in the tubes of the test apparatus (Electrolab, India) and disks were kept over it. The test was carried out in the simulated saliva maintained at 37 C, till the film completely disintegrates. from the dissolution flasks at various time intervals which were replaced with an equivalent volume of dissolution media. Zolmitriptan in the samples was determined by spectrophotometric analysis at appropriate λ max nm. RESULT AND DISCUSSION As reported in Table 2 the thickness of formulated films varied from mm to mm that increased with the concentration of the polymer and total solid content. The acidic or alkaline ph may cause irritation of oral mucosa and can also influence hydration of polymer Disintegration time by Petri Dish method [6] The film containing dose equivalent of drug (zolmitriptan) was placed on a stainless steel wire mesh kept in a Petri dish containing 10 ml of phosphate buffer (ph 6.8) at 37±0.5 C. The time required for the film to break was noted as in vitro disintegration time. All studies were performed in triplicate for each batch. In vitro dissolution study The in vitro dissolution studies were carried out using USP paddle Type 2 dissolution apparatus (Electrolab, Mumbai). The dissolution media was simulated saliva (ph 6.8) and simulated gastric fluid maintained at 37 ± 0.5 C at 50 rpm. 5 ml of the samples were withdrawn Figure 1: In vitro dissolution studies of zolmitriptan films in phosphate buffer (ph6.8) Figure 2: In vitro dissolution profile of fast dissolving oral thin film of zolmitriptan at ph 1.2 Table 2: Evaluation parameters of zolmitriptan fast dissolving OTF Batch Thickness (mm) Weight (mg) Drug content (%) Surface ph PMA PML Z ± ± ± ± ± ±0.23 Z ± ± ± ± ± ±0.33 Z ± ± ± ± ± ±0.54 Z ± ± ± ± ± ±0.21 Z ± ± ± ± ± ±0.65 Z ± ± ± ± ± ±0.01 Z ± ± ± ± ± ±0.04 Z ± ± ± ± ± ±0.05 Z ± ± ± ± ± ±0.01 Table 3: Evaluation of mechanical property and disintegration time of zolmitriptan loaded OTFs Formulation Folding endurance Tensile strength (N/cm 2 ) Elongation (%) In vitro disintegration time (s) Disintegration time (Petri dish) (s) Z1 50± ± ±2 45± ±1.52 Z2 59± ± ±1 48±2 52±1.15 Z3 62± ± ±2 50± ±1.52 Z4 77± ± ±1 60±1.1 70±1 Z5 82± ± ±1 69± ±1 Z6 74± ± ± ± ±1.5 Z7 80± ± ±1 70± ±1.73 Z8 74± ± ±2 75± ±2.52 Z9 64± ± ± ± ± Journal of Pharmacy Research Vol 12 Issue
4 as well as the stability of drug β-cyclodextrin complex, and thus, surface ph of all the formulated batches was determined. It was found to be within the range of As the ph was approximately similar to ph of oral cavity, there were no chances of irritation of oral mucosa. The film flexibility was found to increase with increase in ratio of cyclodextrin w.r.t drug from 1:1 to 1:2 (D: β-cyclodextrin may be due to increase in the solubility of zolmitriptan in presence of β-cyclodextrin, but it decreases at higher concentration of HPMC E5 due to increase in thickness of the film). In vitro disintegration time mentioned in Table 3 was found to increase with an increase in the concentration of polymer used. All the batches of fast dissolving strips for each formulation disintegrated in <2 min in vitro. Thickness and tensile strength of film also increased with increase in the concentration of polymer. Thus, a compromise was reached between moderate tensile strength and minimum disintegration time. In vitro Drug Release Studies The in vitro drug release for the fast dissolving OTFs of the antimigraine drug was carried out in both phosphate buffer (ph 6.8) and 0.1 N HCl dissolution media reported in Tables 4 and 5 respectively. After 10 min, more than 80% of zolmitriptan was released from batches at ph 6.8, while more than 99% of the drug released after 10 min interval from all the films in dissolution media of 0.1 N HCl. The difference in the amount of drug released in different media might be due to the formation of complex with β-cyclodextrin from which drug released more rapidly at the acidic ph than at ph 6.8. The SEM of drug loaded film (Figures 3 and 4) clearly show uniform distribution of zomitriptan within polymeric film. Fourier transform infrared (FTIR) spectra of the physical mixture of components (Figure 5) indicate that there were no major changes in the FTIR spectra indicating Figure 3: Scanning electron microscopy of zolmitriptan fast dissolving oral thin film at 100 Table 4: In vitro dissolution release data profile of fast dissolving OTF of zolmitriptan at ph 6.8 Time (min) Cumulative drug release (%) Z1 Z2 Z3 Z4 Z5 Z6 Z7 Z8 Z ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ±0.52 Table 5: In vitro dissolution data of fast dissolving OTF of zolmitriptan at ph 1.2 Time (min) Cumulative drug release (%) Z1 Z2 Z3 Z4 Z5 Z6 Z7 Z8 Z ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ± ±0.67 Table 6: Stability study of zolmitriptan fast dissolving OTF Time Physical appearance % Drug content Disintegration time (s) Tensile strength (N/cm 2 ) Initial Translucent thin film 99.71± ± month Translucent thin film 99.3± ± months Translucent thin film 99.34± ± months Opaque thin film 98.85± ± Journal of Pharmacy Research Vol 12 Issue
5 no chemical interaction between the components. However, changes observed in the FTIR spectra of optimized fast dissolving OTF i.e (Figure 6) might be due to the complexation between antimigraine triptan and β-cyclodextrin. Optimized film was analyzed by differential scanning calorimetry (DSC) spectra (Figure 8) and compared with DSC spectra of pure drug i.e (Figure 7). Zolmitriptan completely losts its crystalline structure, and thus, no visible peak was seen at the corresponding melting point of the pure drug. The disappearance of the peak of crystalline molecule on inclusion complex formation had been reported in many research works. Figure 4: Scanning electron microscopy of zolmitriptan fast dissolving oral thin film at 500 Stability Studies of Optimized Batch As per the ICH Q1A (R2) guidelines, the stability of each drug-loaded fast dissolving OTF was investigated. Optimized batches of films were studied Figure 5: Fourier transforms infrared of a physical mixture of major components of optimized fast dissolving oral thin film Figure 6: Fourier transforms infrared of optimized fast dissolving oral thin film of zolmitriptan 172 Journal of Pharmacy Research Vol 12 Issue
6 CONCLUSION Figure 7: Differential scanning calorimetry thermogram of pure zolmitriptan Zolmitriptan fast dissolving OTFs were successfully formulated by exploiting the features of HPMC E5 as film-forming polymer as well as a stabilizer of cyclodextrin complexes while the β-cyclodextrin formed inclusion complex with the drug and as reported in not only mask the bitterness of triptans but also enhance its permeation. The thin film formulations are more convenient for the migraine patients experiencing associated nausea and difficulty in swallowing tablets or liquids. REFERENCES Figure 8: Differential scanning calorimetry thermogram of optimized zolmitriptan film for stability parameters at 40 ± 2 C/75% RH ± 5% RH for six months, observations were summerized in Table 6. The formulations showed satisfactory tensile strength, disintegration time, and drug content without any alteration in the physical characteristics, thus confirming their stability. 1. Adelman JU, Lewit EJ. Comparative aspects of triptans in treating migraine. Clin Cornerstone 2001;4: Diener H. Novel approaches in migraine treatment. Nov Approaches Migraine Treat 2013;2-4. DOI: / ebo Gladstone JP, Gawel M. Newer formulations of the triptans: Advances in migraine management. Drugs 2003;63: Stella VJ, Rajewski RA. Cyclodextrins: Their future in drug formulation and delivery. Pharm Res 1997;14: Bansal G, Vipin G. Ternary complexation approach for the development of oral thin films of Rizatriptan benzoate. JPR BioMedRx Int J 2013;1: Garsuch V, Breitkreutz J. Comparative investigations on different polymers for the preparation of fast-dissolving oral films. J Pharm Pharmacol 2010;62: Alagusundaram M, Chetty CM, Dhachinamoorthi D. Development and evaluation of novel-trans-buccoadhesive films of famotidine. J Adv Pharm Technol Res 2011;2: Kunte S, Tandale P. Fast dissolving strips: A novel approach for the delivery of verapamil. J Pharm Bioallied Sci 2010;2: Journal of Pharmacy Research Vol 12 Issue
7. SUMMARY, CONCLUSION AND RECOMMENDATIONS
211 7. SUMMARY, CONCLUSION AND RECOMMENDATIONS Drug absorption from the gastro intestinal tract can be limited by various factors with the most common one being poor aqueous solubility and poor permeability
More informationFormulation and evaluation of sublingual tablets of lisinopril
Journal of GROVER Scientific & Industrial AGARWAL: Research FORMULATION AND EVALUATION OF SUBLINGUAL TABLETS OF LISINOPRIL Vol. 71, June 2012, pp. 413-417 413 Formulation and evaluation of sublingual tablets
More informationEVALUATION OF EFFERVESCENT FLOATING TABLETS. 6.7 Mathematical model fitting of obtained drug release data
EVALUATION OF EFFERVESCENT FLOATING TABLETS 6.1 Technological characteristics of floating tablets 6.2 Fourier transform infrared spectroscopy (FT-IR) 6.3 Differential scanning calorimetry (DSC) 6.4 In
More informationFormulation and Evaluation
Chapter-5 Formulation and Evaluation 5.1 OBJECTIVE After successful taste masking and solubility enhancement of drugs in preliminary studies, by using Mannitol Solid Dispersion, next step includes the
More informationComparative study of different solubility enhancement techniques on dissolution rate of zaltoprofen
World Journal of Pharmaceutical Sciences ISSN (Print): 2321-3310; ISSN (Online): 2321-3086 Published by Atom and Cell Publishers All Rights Reserved Available online at: http://www.wjpsonline.org/ Original
More informationFORMULATION AND CHARACTERIZATION OF TELMISATAN SOLID DISPERSIONS
International Journal of PharmTech Research CODEN (USA): IJPRIF ISSN : 974-434 Vol.2, No.1, pp 341-347, Jan-Mar 1 FORMULATION AND CHARACTERIZATION OF TELMISATAN SOLID DISPERSIONS Kothawade S. N. 1 *, Kadam
More informationFABRICATION AND EVALUATION OF GLIMEPIRIDE CORDIA DICHOTOMA G.FORST FRUIT MUCILAGE SUSTAINED RELEASE MATRIX TABLETS
Int. J. Chem. Sci.: 7(4), 2009, 2555-2560 FABRICATION AND EVALUATION OF GLIMEPIRIDE CORDIA DICHOTOMA G.FORST FRUIT MUCILAGE SUSTAINED RELEASE MATRIX TABLETS HINDUSTAN ABDUL AHAD *, B. PRADEEP KUMAR, C.
More informationCHAPTER VI FACTORIAL STUDIES ON THE EFFECTS OF CYCLODEXTRINS AND SOLUTOL HS15 ON THE SOLUBILITY AND DISSOLUTION RATE OF EFAVIRENZ AND RITONAVIR
CHAPTER VI FACTORIAL STUDIES ON THE EFFECTS OF CYCLODEXTRINS AND SOLUTOL HS15 ON THE SOLUBILITY AND DISSOLUTION RATE OF EFAVIRENZ AND RITONAVIR Efavirenz and ritonavir, two widely prescribed anti retroviral
More informationGlobal College of Pharmacy, Kahnpur Khui, Tehsil Anandpur Sahib, Distt.- Ropar, Punjab, India
IJPSR (2012), Vol. 3, Issue 09 (Research Article) Received on 19 May, 2012; received in revised form 25 June, 2012; accepted 27 August, 2012 IN-VITRO EVALUATION OF TWO MARKETED BRANDS OF PARACETAMOL TABLETS
More informationPatel B et al. IRJP 1 (1)
INTERNATIONAL RESEARCH JOURNAL OF PHARMACY Available online http://www.irjponline.com Research Article IMPROVEMENT OF SOLUBILITY OF CINNARIZINE BY USING SOLID DISPERSION TECHNIQUE Patel Bipin*, Patel Jayvadan,
More informationChemate and Chowdary, IJPSR, 2012; Vol. 3(7): ISSN:
IJPSR (2012), Vol. 3, Issue 07 (Research Article) Received on 18 March, 2012; received in revised form 25 April, 2012; accepted 22 June, 2012 A FACTORIAL STUDY ON ENHANCEMENT OF SOLUBILITY AND DISSOLUTION
More informationTransdermal Delivery of Newer Atypical Antipsychotics ABSTRACT
Transdermal Delivery of Newer Atypical Antipsychotics ABSTRACT Abstract Risperidone and olanzapine, newer atypical antipsychotics are highly effective and safer in the treatment of psychosis. A low dose
More informationFormulation and In-vitro Evaluation of Chewable Tablets of Montelukast Sodium
Available online on www.ijddt.com International Journal of Drug Delivery Technology 214; (3); 98-13 Research Article ISSN: 97 441 Formulation and In-vitro Evaluation of Chewable Tablets of Montelukast
More informationFormulation and evaluation of Orodispersible tablets to enhance dissolution rate of Lamotrigine by using Solid Dispersion Technique
35 Formulation and evaluation of Orodispersible tablets to enhance dissolution rate of Lamotrigine by using Solid Dispersion Technique Bhumi B. Patel 1 *, Chainesh N. Shah 2, Rumit M. Shah 3 1 Department
More informationINTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND BIO-SCIENCE
INTERNATIONAL JOURNAL OF PHARMACEUTICAL RESEARCH AND BIO-SCIENCE DESIGN AND CHARACTERISATION OF FAST DISSOLVING SUBLINGUAL FILMS OF MONTELUKAST SODIUM PRABHU SC, PARSEKAR S, SHETTY A, MONTEIRO SS, AZHARUDDIN
More informationskim milk as carrier by kneading method. They were evaluated for percentage yield, drug content, FT-IR
Available Online through ISSN: 0975-766X CODEN: IJPTFI Research Article www.ijptonline.com ENHANCEMENT OF SOLUBILITY & DISSOLUTION RATE OF LAMOTRIGINE BY KNEADING METHOD Gadhave M.V*, Mahakal A. J., Gaikwad
More informationFormulation and evaluation of fast dissolving tablet of aceclofenac
International Journal of Drug Delivery 2 (2010) 93-97 http://www.arjournals.org/ijdd.html Research article ISSN: 0975-0215 Formulation and evaluation of fast dissolving tablet of aceclofenac Sudhir Bhardwaj
More informationVolume: 2: Issue-3: July-Sept ISSN FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF NICORANDIL
Volume: 2: Issue-3: July-Sept -2011 ISSN 0976-4550 FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF NICORANDIL Ajaykumar Patil*, Ashish Pohane, Ramya Darbar, Sharanya Koutika, Alekhya
More informationFACTORIAL STUDIES ON THE EFFECTS OF HYDROXY PROPYL β- CYCLODEXTRIN AND POLOXAMER 407 ON THE SOLUBILITY AND DISSOLUTION RATE OF BCS CLASS II DRUGS
JChrDD Vol 2 Issue 2 2011: 89-93 ISSN 2249-6785 Journal of Chronotherapy and Drug Delivery Received: August 06, 2011 Accepted: Sep 12, 2011 Original Research Paper FACTORIAL STUDIES ON THE EFFECTS OF HYDROXY
More informationIJRPB 1(5) September October 2013 Page 629
FORMULATION AND EVALUATION OF TRANSDERMAL PATCHES OF ANTI- HYPERTENSIVE DRUG METOPROLOL SUCCINATE Koteswararao P 1*, Duraivel S 1, Sampath Kumar KP 2, Debjit Bhowmik 3 1. Nimra College Of Pharmacy,Vijayawada,
More informationFormulation Development and Characterization of Levosalbutamol Sulphate Oral Thin Film using Propylene glycol as a Plasticizer
Bangladesh Pharmaceutical Journal 20(1): 64-70, 2017 Formulation Development and Characterization of Levosalbutamol Sulphate Oral Thin Film using Propylene glycol as a Plasticizer Md. Masud Morshed 1,
More informationFORMULATION AND DEVELOPMENT OF ER METOPROLAOL SUCCINATE TABLETS
International Journal of PharmTech Research CODEN( USA): IJPRIF ISSN : 0974-4304 Vol.1, No.3, pp 634-638, July-Sept 2009 FORMULATION AND DEVELOPMENT OF ER METOPROLAOL SUCCINATE TABLETS K. Reeta Vijaya
More informationFORMULATION AND EVALUATION OF DIPHENHYDRAMINE HYDROCHLORIDE LOZENGES FOR TREATMENT OF COUGH
WORLD JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES Patel et al. Volume 3, Issue 5, 822-834. Research Article ISSN 2278 4357 FORMULATION AND EVALUATION OF DIPHENHYDRAMINE HYDROCHLORIDE LOZENGES FOR TREATMENT
More informationSTABILITY STUDIES OF FORMULATED CONTROLLED RELEASE ACECLOFENAC TABLETS
Int. J. Chem. Sci.: 8(1), 2010, 405-414 STABILITY STUDIES OF FORMULATED CONTROLLED RELEASE ACECLOFENAC TABLETS V. L. NARASAIAH, T. KARTHIK KUMAR, D. SRINIVAS, K. SOWMYA, P. L. PRAVALLIKA and Sk. Md. MOBEEN
More information3.1 Background. Preformulation Studies
Preformulation Studies 3.1 Background Delivery of any drug requires a suitable dosage form to get optimum therapeutic effects. The development of such dosage forms fundamental properties of the drug molecule
More informationEffect of Polymer Concentration and Viscosity Grade on Atenolol Release from Gastric Floating Drug Delivery Systems
Effect of Polymer Concentration and Viscosity Grade on Atenolol Release from Gastric Floating Drug Delivery Systems 1 1 1 2 U.V. Bhosale*, V. Kusum Devi, Nimisha Jain and P.V. Swamy 1 Al-Ameen College
More informationA FACTORIAL STUDY ON ENHANCEMENT OF SOLUBILITY AND DISSOLUTION RATE OF IBUPROFEN BY β CYCLODEXTRIN AND SOLUTOL HS15
INTERNATIONAL JOURNAL OF RESEARCH IN PHARMACY AND CHEMISTRY Available online at www.ijrpc.com Research Article A FACTORIAL STUDY ON ENHANCEMENT OF SOLUBILITY AND DISSOLUTION RATE OF IBUPROFEN BY β CYCLODEXTRIN
More informationScholars Research Library
Available online at www.scholarsresearchlibrary.com Scholars Research Library Der Pharmacia Lettre, 2011, 3(1): 382-395 (http://scholarsresearchlibrary.com/archive.html) ISSN 0975-5071 USA CODEN: DPLEB4
More informationMixed Hydrotropy: Novel Science of Solubility Enhancement
Research Paper Mixed Hydrotropy: Novel Science of Solubility Enhancement R. K. MAHESHWARI* AND Y. JAGWANI Shri G. S. Institute of Technology and Science, 23-Park Road, Indore-452 003, Madhya Pradesh, India
More informationFolic Acid in Human Nutrition
Folic Acid in Human Nutrition Folic acid is a water soluble B vitamin widely distributed in foods. Deficiencies lead to impaired cell division and altered protein synthesis. Newborn children of women receiving
More informationENHANCEMENT OF SOLUBILITY AND DISSOLUTION RATE OF NIMESULIDE BY CYCLODEXTRINS, POLOXAMER AND PVP
Int. J. Chem. Sci.: 9(2), 20, 637-646 ISSN 0972-768X www.sadgurupublications.com ENHANCEMENT OF SOLUBILITY AND DISSOLUTION RATE OF NIMESULIDE BY CYCLODEXTRINS, POLOXAMER AND PVP K. P. R. CHOWDARY *, K.
More informationENHANCEMENT OF SOLUBILITY OF BICALUTAMIDE DRUG USING SOLID DISPERSION TECHNIQUE
PHARMA SCIENCE MONITOR AN INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES ENHANCEMENT OF SOLUBILITY OF BICALUTAMIDE DRUG USING SOLID DISPERSION TECHNIQUE Kantilal B. Narkhede *1, R. B. Laware 2, Y. P.
More informationFormulation and Development of Sustained Release Tablets of Valsartan Sodium
INTERNATIONAL JOURNAL OF ADVANCES IN PHARMACY, BIOLOGY AND CHEMISTRY Research Article Formulation and Development of Sustained Release Tablets of Valsartan Sodium G. Sandeep * and A. Navya Department of
More informationFormulation and Evaluation of Medicated Nail Patches for the Treatment of Onychomycosis
International Journal of Pharmaceutical Science Invention ISSN (Online): 2319 6718, ISSN (Print): 2319 670X Volume 7 Issue 4 Ver. I April 2018 PP.52-58 Formulation and Evaluation of Medicated Nail Patches
More informationPharmaceutical Studies on Formulation and Evaluation of Sustained Release Tablets Containing Certain Drugs
Mansoura University Faculty of Pharmacy Department of Pharmaceutics Pharmaceutical Studies on Formulation and Evaluation of Sustained Release Tablets Containing Certain Drugs Thesis presented by Ali Saeed
More informationBiowaiver Study on Prednisolone Tablets 5 mg in Three Different Brands. Marketed in Sudan. Safaa Mohamed *, Tilal Elsaman
Available online at www.scholarsresearchlibrary.com Scholars Research Library Der Pharmacia Lettre, 2017, 9 [4]:8-114 [http://scholarsresearchlibrary.com/archive.html] ISSN 0975-5071 USA CODEN: DPLEB4
More informationInternational Journal of Pharma Sciences and Scientific Research
Research Article International Journal of Pharma Sciences and Scientific Research ISSN 2471-6782 Open Access Formulation, development and evaluation of rivaroxaban tablets by using solubility enhancement
More informationSTUDIES ON EFFECT OF BINDERS ON ETORICOXIB TABLET FORMULATIONS
Int. J. Chem. Sci.: 10(4), 2012, 1934-1942 ISSN 0972-768X www.sadgurupublications.com STUDIES ON EFFECT OF BINDERS ON ETORICOXIB TABLET FORMULATIONS K. VENUGOPAL * and K. P. R. CHOWDARY a Nirmala College
More informationFormulation and evaluation of oro-dispersible tablets of lafutidine
Available online at www.scholarsresearchlibrary.com Scholars Research Library Der Pharmacia Lettre, 2015, 7 (5):226-235 (http://scholarsresearchlibrary.com/archive.html) ISSN 0975-5071 USA CODEN: DPLEB4
More informationFormulation Development of Aceclofenac Tablets Employing Starch Phosphate -A New Modified Starch
Abstract K.P.R. Chowdary et al. / International Journal of Pharma Sciences and Research (IJPSR) Formulation Development of Aceclofenac Tablets Employing Starch Phosphate -A New Modified Starch K.P.R. Chowdary*,
More informationJournal of Pharmaceutical and Scientific Innovation
Journal of Pharmaceutical and Scientific Innovation www.jpsionline.com Research Article ENHANCEMENT OF SOLUBILITY AND DISSOLUTION RATE OF ROSUVASTATIN BY USING SOLID DISPERSION TECHNIQUE Swathi T 1 *,
More informationFormulation and Evaluation of Fast Disintegrating Tablets of Caffeine by Using Effervescent Formulation Approach
Available online at www.scholarsresearchlibrary.com Scholars Research Library Der Pharmacia Lettre, 212, 4 (5):149-1494 (http://scholarsresearchlibrary.com/archive.html) ISSN 975-571 USA CODEN: DPLEB4
More informationAvailable Online through Research Article
ISSN: 0975-766X Available Online through Research Article www.ijptonline.com DESIGN AND EVALUATION OF GASTRORETENTIVE TABLETS FOR CONTROLLED DELIVERY OF NORFLOXOCIN Ganesh Kumar Gudas*, Subal Debnath,
More informationFORMULATION AND EVALUATION OF MELT-IN-MOUTH TABLETS OF DOMPERIDONE CONTAINING MULTICOMPONENT INCLUSION COMPLEX
Academic Sciences International Journal of Pharmacy and Pharmaceutical Sciences ISSN- 0975-1491 Vol 4, Issue 1, 2012 Research Article FORMULATION AND EVALUATION OF MELT-IN-MOUTH TABLETS OF DOMPERIDONE
More informationFormulation and evaluation of immediate release salbutamol sulphate
5 Formulation, optimization and evaluation of immediate release layer of salbutamol sulphate Salbutamol is moderately selective beta (2)-receptor agonist similar in structure to terbutaline and widely
More informationEFFECT OF PVP ON CYCLODEXTRIN COMPLEXATION OF EFAVIRENZ FOR ENHANCING ITS SOLUBILITY AND DISSOLUTION RATE
INTERNATIONAL JOURNAL OF RESEARCH IN PHARMACY AND CHEMISTRY Available online at www.ijrpc.com Research Article EFFECT OF PVP ON CYCLODEXTRIN COMPLEXATION OF EFAVIRENZ FOR ENHANCING ITS SOLUBILITY AND DISSOLUTION
More informationLubriTose Mannitol Michael Crowley, Director of R&D, Excipients
LubriTose Mannitol Michael Crowley, Director of R&D, Excipients Introduction Michael Crowley Director of R&D Excipients 158 St. Highway 320 Norwich, NY 13815 PH 315-802-5970 Michael.Crowley@Kerry.com 2
More informationImproving Micromeritic Properties of Ibuprofen: An Agglomeration Approach
Bangladesh Pharmaceutical Journal 20(1): 90-98, 2017 Improving Micromeritic Properties of Ibuprofen: An Agglomeration Approach Md. Sazzadul Islam and Md. Saiful Islam Pathan Department of Pharmacy, State
More informationVolume: I: Issue-2: Aug-Oct ISSN NOVEL APPROACH IN FORMULATION AND EVALUATION OF MOUTH DISSOLVING TABLETS OF ONDANSETRON HYDROCHLORIDE
Volume: I: Issue-2: Aug-Oct -2010 ISSN 0976-4550 NOVEL APPROACH IN FORMULATION AND EVALUATION OF MOUTH DISSOLVING TABLETS OF ONDANSETRON HYDROCHLORIDE * Hindustan Abdul Ahad, Anuradha CM, Chitta Suresh
More informationA FACTORIAL STUDY ON THE ENHANCEMENT OF DISSOLUTION RATE OF KETOPROFEN BY SOLID DISPERSION IN COMBINED CARRIERS
Research Article A FACTORIAL STUDY ON THE ENHANCEMENT OF DISSOLUTION RATE OF KETOPROFEN BY SOLID DISPERSION IN COMBINED CARRIERS K. P. R. Chowdary *, Tanniru Adinarayana, T. Vijay, Mercy. R. Prabhakhar
More informationA STUDY ON SUITABILITY OF NIMESULIDE-BETACYCLODEXTRIN COMPLEX IN ORAL AND TOPICAL DOSAGE FORMS
International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 1, Suppl 1, Nov.-Dec. 2009 Research Article A STUDY ON SUITABILITY OF NIMESULIDE-BETACYCLODEXTRIN COMPLEX IN ORAL AND TOPICAL DOSAGE
More informationInternational Journal of Medicine and Pharmaceutical Research
International Journal of Medicine and Pharmaceutical Research Journal Home Page: www.pharmaresearchlibrary.com/ijmpr Research Article Open Access Formulation and Evaluation of Gastroretentive Floating
More informationKarnataka Department of Pharmaceutical Technology, H.K.E. Society s College of Pharmacy, Gulbarga, Karnataka ABSTRACT KEYWORDS:
335 P a g e International Standard Serial Number (ISSN): 2319-8141 International Journal of Universal Pharmacy and Bio Sciences 4(6): November-December 2015 INTERNATIONAL JOURNAL OF UNIVERSAL PHARMACY
More informationENHANCEMENT OF SOLUBILITY, DISSOLUTION RATE AND BIOAVAILABILITY OF RITONAVIR BY CYCLODEXTRINS AND SOLUTOL HS15 - A FACTORIAL STUDY
INTERNATIONAL JOURNAL OF RESEARCH IN PHARMACY AND CHEMISTRY Available online at www.ijrpc.com Research Article ENHANCEMENT OF SOLUBILITY, DISSOLUTION RATE AND BIOAVAILABILITY OF RITONAVIR BY CYCLODEXTRINS
More informationPreparation and Characterization of Candesartan Cilexetil Solid Lipid Nanoparticulate Capsules
Research Article Preparation and Characterization of Candesartan Cilexetil Solid Lipid Nanoparticulate Capsules *Surya Kiran Vuddisa, Subramanian S., Sindhu Raavi Department of Pharmaceutics, PSG College
More informationDESIGN, DEVELOPMENT AND OPTIMIZATION OF FAST DISSOLVING TABLET OF NEBIVOLOL HCL
DESIGN, DEVELOPMENT AND OPTIMIZATION OF FAST DISSOLVING TABLET OF NEBIVOLOL HCL Isha Shah, Alpesh Yadav, Shailendra Bhatt Maharishi Arvind Institute of Pharmacy, Mansarovar, Jaipur, India-3000. Abstract
More informationMEDAK DIST. ANDHRA PRADESH STATE, INDIA. Research Article RECEIVED ON ACCEPTED ON
Page67 Available Online through IJPBS Volume 1 Issue 2 APRIL- JUNE 2011 SIMPLE QUANTITATIVE METHOD DEVELOPMENT AND VALIDATION OF VALSARTAN IN PUREFORM AND PHARMACEUTICAL DOSAGE FORMS BYUV SPECTROSCOPY
More informationOPTIMIZATION OF CONTROLLED RELEASE GASTRORETENTIVE BUOYANT TABLET WITH XANTHAN GUM AND POLYOX WSR 1105
Digest Journal of Nanomaterials and Biostructures Vol. 9, No. 3, July September 2014, p. 1077-1084 OPTIMIZATION OF CONTROLLED RELEASE GASTRORETENTIVE BUOYANT TABLET WITH XANTHAN GUM AND POLYOX WSR 1105
More informationSOLID INCLUSION COMPLEXES OF CLASS II IMIDAZOLE DERIVATIVE WITH Β CYCLODEXTRIN. Pradesh.
Continental J. Pharmaceutical Sciences 1: 1-8, 2007. Wilolud Online Journals, 2007. SOLID INCLUSION COMPLEXES OF CLASS II IMIDAZOLE DERIVATIVE WITH Β CYCLODEXTRIN Tarun Virmani 1, Nayyar Parvez* 1, Suman
More informationCOMPARATIVE IN VITRO EVALUATION OF COMMERCIALLY AVAILABLE PANTOPRAZOLE DELAYED RELEASE TABLETS
343 P a g e International Standard Serial Number (ISSN): 2319-8141 International Journal of Universal Pharmacy and Bio Sciences 3(4): July-August 2014 INTERNATIONAL JOURNAL OF UNIVERSAL PHARMACY AND BIO
More informationCompliance. Should you have any questions, please contact Behnaz Almasi, Associate Scientific Liaison ( or
Extended-Release Tablets Type of Posting Revision Bulletin Posting Date 30 Mar 2018 Official Date 01 Apr 2018 Expert Committee Chemical Medicines Monographs 3 Reason for Revision Compliance In accordance
More informationAsian Journal of Pharmacy and Life Science ISSN Vol. 2 (2), July-Sept,2012
STUDIES ON EFFECT OF SUPERDISINTEGRANTS ON ETORICOXIB TABLET FORMULATIONS Chowdary K. P. R 1, Venugopal. K *2 1 College of Pharmaceutical Sciences, Andhra University, Vishakapattanam. 2 * Nirmala college
More informationAvailable Online through
ISSN: 0975-766X Available Online through Research Article www.ijptonline.com FORMULATION DESIGN AND OPTIMIZATION OF MOUTH DISSOLVE TABLETS OF GLIPIZIDE R.Shireesh Kiran 1*, B.Chander Shekar 1, Sharadha
More informationA study on the effects of different surfactants on Ethylcellulose microspheres
International Journal of PharmTech Research CODEN (USA): IJPRIF ISSN : 0974-4304 Vol.1, No.4, pp 966-971, Oct-Dec 2009 A study on the effects of different surfactants on Ethylcellulose microspheres Lalduhsanga
More informationAsian Journal of Pharmacy and Life Science ISSN Vol. 1 (4), Oct-Dec, 2011
Asian Journal of Pharmacy and Life Science ISSN 223 4423 Vol. (4), OctDec, 20 Preparation, Evaluation and Characterization of Solid Dispersion of Piroxicam Priya Jain*, Dheeraj Jain 2, Prasoon Dwivedi,
More informationDEVELOPMENT AND IN VITRO EVALUATION OF SUSTAINED RELEASE FLOATING MATRIX TABLETS OF METFORMIN HYDROCHLORIDE
ISSN: 0975-8232 IJPSR (2010), Vol. 1, Issue 8 (Research article) Received 11 April, 2010; received in revised form 17 June, 2010; accepted 13 July, 2010 DEVELOPMENT AND IN VITRO EVALUATION OF SUSTAINED
More informationDevelopment and evaluation of mucoadhesive films of Acyclovir in oral environment- along with model study on Chlorhexidine
Available online at www.scholarsresearchlibrary.com Scholars Research Library Der Pharmacia Lettre, 2013, 5 (6):60-66 (http://scholarsresearchlibrary.com/archive.html) ISSN 0975-5071 USA CODEN: DPLEB4
More informationThe present work was designed to develop suitable transdermal matrix patches of tramadol hydrochloride, a non-steroidal
RESEARCH ARTICLE Development and characterization of transdermal therapeutics system of tramadol hydrochloride Anil J Shinde, Kevin C Garala, Harinath N More Department of Pharmaceutics, Bharati Vidyapeeth
More informationFormulation and Characterization of Buccal Mucoadhesive Patch of Chlorhexidine Gluconate
International Journal of PharmTech Research CODEN (USA): IJPRIF ISSN : 0974-4304 Vol.6, No.1, pp 06-10, Jan-March 2014 Formulation and Characterization of Buccal Mucoadhesive Patch of Chlorhexidine Gluconate
More informationInternational Journal of Pharmacy
International Journal of Pharmacy Journal Homepage: http://www.pharmascholars.com Research Article CODEN: IJPNL6 FORMULATION AND EVALUATION OF ZOLMITRIPTAN FAST DISSOLVING TABLET USING SYNTHETIC SUPERDISINTEGRANTS
More informationFORMULATION AND EVALUATION OF SUBLINGUAL TABLET FOR NARATRIPTA
Brahmbhatt et al Journal of Drug Delivery & Therapeutics; 2014, 4(4), 19-23 19 Available online on 15.07.2014 at http://jddtonline.info Journal of Drug Delivery and Therapeutics Open access to Pharmaceutical
More informationPatel et al Journal of Drug Delivery & Therapeutics; 2012, 2(1) 41 Available online at
Patel et al Journal of Drug Delivery & Therapeutics; 2012, 2(1) 41 Available online at http://jddtonline.info RESEARCH ARTICLE FORMULATION AND EVALUATION OF MATRIX DIFFUSION CONTROLLED TRANSDERMAL DRUG
More informationComparative Dissolution Study of Glipizide by Solid Dispersion Technique
Comparative Dissolution Study of Glipizide by Solid Dispersion Technique Dehghan M H G 1, Saifee M 1, Hanwate R M 2 1 Y.B.Chavan College of Pharmacy,Dr. Rafiq Zakaria campus, Aurangabad-431001, Maharashtra,
More informationFORMULATION AND EVALUATION OF DILTIAZEM HYDROCHLORIDE COLON TARGETED TABLETS
INTERNATIONAL JOURNAL OF RESEARCH IN PHARMACY AND CHEMISTRY Available online at www.ijrpc.com Research Article FORMULATION AND EVALUATION OF DILTIAZEM HYDROCHLORIDE COLON TARGETED TABLETS G. Subba Rao
More informationJournal of Chemical and Pharmaceutical Research
Available on line www.jocpr.com Journal of Chemical and Pharmaceutical Research ISSN No: 0975-7384 CODEN(USA): JCPRC5 J. Chem. Pharm. Res., 2011, 3(3):348-352 Formulation and in vitro evaluation of modified
More informationDEVELOPMENT OF NON SODIUM EFFERVESCENT TABLET OF PARACETAMOL USING ARGININE CARBONATE
IJPSR (2013), Vol. 4, Issue 5 (Research Article) Received on 17 July, 2012; received in revised form, 23 February, 2013; accepted, 14 April, 2013 DEVELOPMENT OF NON SODIUM EFFERVESCENT TABLET OF PARACETAMOL
More informationInternational Journal of Pharma and Bio Sciences V1(1)2010 FORMULATION AND EVALUATION OF ROSIGLITAZONE MOUTH DISSOLVING TABLET
G ARJUN 1*, M.SRAVAN PRASAD 1, D SANTHOSHA 1 AND G.ACHAIAH 2 1 Nalanda college of pharmacy, Osmania University, Nalgonda, India. 2 University College of Pharmaceutical Sciences, Kakatiya University, Warangal,
More informationDEVELOPMENT AND CHARACTERIZATION OF SELF EMULSIFYING DRUG DELIVERY SYSTEM OF A POORLY WATER SOLUBLE DRUG USING NATURAL OIL
Acta Poloniae Pharmaceutica ñ Drug Research, Vol. 69 No. 4 pp. 713ñ717, 2012 ISSN 0001-6837 Polish Pharmaceutical Society PHARMACEUTICAL TECHNOLOGY DEVELOPMENT AND CHARACTERIZATION OF SELF EMULSIFYING
More informationJournal of Global Trends in Pharmaceutical Sciences Vol.2, Issue 4, pp , Oct -Dec 2011
ISSN: 223-7346 Research Article Journal of Global Trends in Pharmaceutical Sciences Vol.2, Issue 4, pp -394-43, Oct -Dec 211 FORMULATION AND INVITRO EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF GLIMEPIRIDE
More informationFormulation, evaluation and optimization of transdermal patches of losartan potassium
World Journal of Pharmaceutical Sciences ISSN (Print): 2321-3310; ISSN (Online): 2321-3086 Published by Atom and Cell Publishers All Rights Reserved Available online at: http://www.wjpsonline.org/ Original
More information685 International Journal of Medicine and Pharmaceutical Research
Rajesh Asija et al Research Article IJMPR, 2014, Vol.2(4): 685-690 ISSN:2321-2624 International Journal of Medicine and Pharmaceutical Research www.pharmaresearchlibrary.com/ijmpr Formulation Development
More informationFORMULATION RELEASE STUDY OF SOME IMPORTANT DRUGS FROM SUPPOSITORY
FORMULATION RELEASE STUDY OF SOME IMPORTANT DRUGS FROM SUPPOSITORY Mohammed Younus Ali*, Sadat Ali JJT University, Churu-Bisau Road, Jhunjhunu Rajasthan ABSTRACT: The purpose of this study was to formulate
More informationScholars Research Library
Available online at www.scholarsresearchlibrary.com Scholars Research Library Der Pharmacia Lettre, 2011, 3(1): 38-44 (http://scholarsresearchlibrary.com/archive.html) ISSN 0975-5071 USA CODEN: DPLEB4
More informationFORMULATION AND IN VITRO EVALUATION OF FAMOTIDINE FLOATING TABLETS BY LIPID SOLID DISPERSION SPRAY DRYING TECHNIQUE
INTERNATIONAL JOURNAL OF RESEARCH IN PHARMACY AND CHEMISTRY Available online at www.ijrpc.com Research Article FORMULATION AND IN VITRO EVALUATION OF FAMOTIDINE FLOATING TABLETS BY LIPID SOLID DISPERSION
More informationLipid Based Matrices as Colonic Drug Delivery System for Diflunisal (In-vitro, In-vivo study)
Lipid Based Matrices as Colonic Drug Delivery System for Diflunisal (In-vitro, In-vivo study) Presented by Dr. AHMED ATEF DONIA, PH. D., Lecturer of Pharmaceutical Technology, Faculty of Pharmacy, Tanta
More informationARTESUNATE TABLETS: Final text for revision of The International Pharmacopoeia (December 2009) ARTESUNATI COMPRESSI ARTESUNATE TABLETS
December 2009 ARTESUNATE TABLETS: Final text for revision of The International Pharmacopoeia (December 2009) This monograph was adopted at the Forty-fourth WHO Expert Committee on Specifications for Pharmaceutical
More informationFORMULATION AND EVALUATION OF VALSARTAN TABLETS EMPLOYING CYCLODEXTRIN-POLOXAMER 407-PVP K30 INCLUSION COMPLEXES
Int. J. Chem. Sci.: 10(1), 2012, 297-305 ISSN 0972-768X www.sadgurupublications.com FORMULATION AND EVALUATION OF VALSARTAN TABLETS EMPLOYING CYCLODEXTRIN-POLOXAMER 407-PVP K30 INCLUSION COMPLEXES K. P.
More informationEzetimibe Solid Dispersions: Formulation, Development and In vitro Evaluation
American Journal of Advanced Drug Delivery www.ajadd.co.uk Original Article Ezetimibe Solid Dispersions: Formulation, Development and In vitro Evaluation Chaitanya P, Jyothi Penta *, Venkat Ratnam Devadasu,
More informationAggarwal Jyoti et al. Int. Res. J. Pharm. 2015, 6 (10) INTERNATIONAL RESEARCH JOURNAL OF PHARMACY
INTERNATIONAL RESEARCH JOURNAL OF PHARMACY www.irjponline.com ISSN 2230 8407 Research Article FORMULATION AND EVALUATION OF ORAL FAST DISSOLVING FILMS OF GRANISETRON HYDROCHLORIDE USING DIFFERENT POLYMERS
More informationThe Relevance of USP Methodology in the Development of a Verapamil Hydrochloride (240 mg) Extended Release Formulation
METHOCEL Premium Cellulose Ethers Application Data The Relevance of USP Methodology in the Development of a Verapamil Hydrochloride (240 mg) Extended Release Formulation INTRODUCTION Hydrophilic matrices
More informationFormulation and evaluation of mouth dissolving film of antipsychotic drug aripiprazole
Available online at www.scholarsresearchlibrary.com Scholars Research Library Der Pharmacia Lettre, 2012, 4 (4):1221-1227 (http://scholarsresearchlibrary.com/archive.html) ISSN 0975-5071 USA CODEN: DPLEB4
More informationFormulation and Evaluation of Transdermal Patches of Nicorandil by Using Different Penetration Enhancer
Human Journals Research Article July 2018 Vol.:12, Issue:4 All rights are reserved by Nagoba Shivappa N et al. Formulation and Evaluation of Transdermal Patches of Nicorandil by Using Different Penetration
More informationFormulation and evaluation of gastro retentive floating tablets of Terbutaline sulphate
Formulation and evaluation of gastro retentive floating tablets of Terbutaline sulphate Lokesh Kumar*, Virendra Singh, Rakesh Kumar Meel Department of Pharmaceutics, Goenka College of Pharmacy, NH-11,
More informationFORMULATION AND EVALUATION OF FLOATING TABLETS OF NORFLOXACIN
FORMULATION AND EVALUATION OF FLOATING TABLETS OF NORFLOXACIN Ms. Jyoti Rathore 1*, Mr. Hitesh Kumar Parmar 1 Ujjain Institute of Pharmaceutical Sciences, Ujjain. Email- hkparmar7@rediffmail.com ABSTRACT
More informationInt. J. Pharm. Sci. Rev. Res., 33(1), July August 2015; Article No. 12, Pages: 55-61
Research Article Sandeep Sathyanarayana D*, Narayana Charyulu R Department of Pharmaceutics, NGSM Institute of Pharmaceutical Sciences, Paneer, Deralakatte, Mangalore, Karnataka, India. *Corresponding
More informationDESIGN AND EVALUATION OF CONTROLLED RELEASE MATRIX TABLETS OF FLURBIPROFEN
Int. J. Chem. Sci.: 10(4), 2012, 2199-2208 ISSN 0972-768X www.sadgurupublications.com DESIGN AND EVALUATION OF CONTROLLED RELEASE MATRIX TABLETS OF FLURBIPROFEN K. V. R. N. S. RAMESH *, B. HEMA KIRNAMAYI
More informationDecentralised Procedure. Public Assessment Report. Zolmitriptan Renantos 2.5 mg Orodispersible film 5 mg Orodispersible film DE/H/2295/ /DC
Bundesinstitut für Arzneimittel und Medizinprodukte Decentralised Procedure Public Assessment Report Zolmitriptan Renantos 2.5 mg Orodispersible film 5 mg Orodispersible film DE/H/2295/001-002/DC Applicant:
More informationFORMULATION DEVELOPMENT AND EVALUATION OF COLON TARGETED DOSAGE FORM OF IBUPROFEN
FORMULATION DEVELOPMENT AND EVALUATION OF COLON TARGETED DOSAGE FORM OF IBUPROFEN Pranjal Kumar Singh*, Sanjoo Kumar, T.S.Easwari, V.K.Shukla, Guru Sharan Department of Pharmaceutics, IIMT College of Medical
More informationFormulation and evaluation of oral dispersible tablets of aripiprazole
IJPAR Vol.6 Issue 2 April - June -17 Journal Home page: ISSN:23-2831 Research article Open Access Formulation and evaluation of oral dispersible tablets of aripiprazole A.Madhusudhan Reddy*, P.Srinivasababu,
More informationMethod Development and Validation of Emtricitabine in Bulk by UV Spectroscopy
Human Journals Research Article February 2019 Vol.:14, Issue:3 All rights are reserved by Gandi Anusha et al. Method Development and Validation of Emtricitabine in Bulk by UV Spectroscopy Keywords: Emtricitabine,
More information