Le reti neuronali del dolore nel paziente emicranico
|
|
- Norman Quinn
- 6 years ago
- Views:
Transcription
1 Le reti neuronali del dolore nel paziente emicranico Antonio Russo Ambulatorio del paziente con cefalee ed algie facciali Clinica Neurologica II Seconda Università degli Studi di Napoli Centro Cefalee Istituto Diagnosi e Cura Hermitage Capodimonte Napoli
2
3
4
5
6 We sought to take advantage of the spatial and temporal resolution of whole brain event-related BOLD fmri to study in migraine pts: functional integrity of the pain matrix functional reorganization of anti-nociceptive pathways even in interictal periods correlation of such alterations with clinical parameters representing disease severity (disease duration, frequency etc )
7 16 Patients with episodic MwA ICHD-II criteria without hypertension, diabetes mellitus, heart disease, other chronic systemic diseases, stroke, substance abuse, other neurological, chronic pain or psychiatric disorders (HAM-A, HAM-D, M.I.N.I) migraine-free (-3 days and +7 days MRI scan) not taking any medications commonly prescribed for migraine prevention or attack medication (until -3 days MRI scan) MIDAS (MIgraine Disability Assessment Scale) and HIT-6 (Headache Impact Test) 16 healthy controls age and sex matched without hypertension, diabetes mellitus, heart disease, other chronic systemic diseases, stroke, substance abuse, other neurological, chronic pain or psychiatric disorders (HAM-A, HAM-D, M.I.N.I)
8 Signa 3T GE - TR: 1500 ms - TE: 32 ms - FOV: 24 mm - matrix 64x64 - flip angle: 90º - slice thickness: 5.0 mm - gap interslice: 0 fmri Data analysis - Brain voyager - Head movement correction, spatial normalization and smoothing with 6 mm FWHM - General Linear model (box-car design convolved with haemodynamic response function) - Random effects analysis (p<0.05 corrected)
9 CHEPS: Contact Heat Evoked Potential Stimulator fmri compatible short thermal stimuli (600ms) were applied to the maxillary skin tested only the side of the face more frequently affected during migraine attacks hot-non painful stimulation at 41 C (Katherine Roberts et al., 2008) painful heat at 51 (Moulton et al 2008) and 53 C degrees (Katherine Roberts et al., 2008) Numerical Rating Scale (M. Burgmer et al., 2010) 41 C 51 C 53 C R A N D O M
10 Patients mean±sd Controls mean±sd Sex 8M / 8F 8M / 8F Mean age y.o y.o. Mean disease duration years N.A. Frequency/month N.A. MIDAS N.A. HIT N.A. Main pain intensity (VAS) N.A. HAM-A HAM-D Side of pain 8R / 8L N.A. Side of stimuli 8R / 8L 8R / 8L
11 41 MAIN effect of stimuli (16 pts + 16 ctl) p < 0.05 corrected 41 C C C
12 Anterior cingulate cortex A B C Patients > Controls Bilateral somatosensory cortex C R Controls > Patients
13 A Patients > Controls 51 C B Pons R Controls > Patients 53 C
14 Numerical Rating Scale M. Burgmer et al. J Neural Transm (2010) Patients Controls p value R 41 C 3,75 + 3,16 3,66 + 2,38 p= 0.47 R 51 C 5,91 + 2, ,44 p= 0.46 R 53 C 7,41 + 2,23 8,41 + 1,31 p= 0.09
15 Results (4b): Group BY Stimulus Interaction (brainstem)
16 preserved integrity of the pain matrix in MwA interictal functional reorganization of cortical and sub-cortical areas in patients with MwA during processing of painful stimuli the brainstem divergent activation between MwA and controls positively correlate with clinical parameters such as frequency, pain intensity and disability.
17 RS-fMRI allows the study of brain functional connectivity at rest no tasks dependent (Raichle ME et al. 2001) In the last decade, several studies have evaluated the integrity of RS-networks in normal aging and different neurodegenerative disorders (Grecius MD et al. 2004; Damoiseaux JS et al. 2008; Galvin et al. 2011) To our knowledge no RS-fMRI studies have been conducted in patients suffering from migraine
18 Resting State Network (RSN) Default mode network associated with internal processing Executive network mediating goal-directed stimulus-response selection Visual network dedicated to visual processing Auditory network corresponding to the auditory-phonological system Sensory-motor network associated with sensorymotor processing Medial ventralprefrontal network related to self-referential mental activity
19 Functional connectivity BOLD response x[t] x y x y[t] y When two regions are functionally connected the local fmri signals (X and Y) are temporally correlated (Raichle ME et al. PNAS 2001)
20 EXECUTIVE-ATTENTION NETWORK DYSFUNCTION IN EPISODIC MIGRAINE WITHOUT AURA A. Russo, A. Tessitore, A. Giordano, L. Marcuccio, M. De Stefano, F. Salemi, D. Corbo, R. Conforti, F. Esposito, G. Tedeschi Cognitive deficits have been reported both during and between migraine episodes (O Bryant et al., 2005) Neuropsychological studies has revealed impaired performance in migraine pts - psychomotor speed and attention (Hooker et al., 1986; Calandre et al., 2005) - executive functioning (Mongini et al., 2005) A neuropsychological study remark the evidence of mild executive dysfunction in the interictal phase of MwoA and emphasize the role of subcortical white matter lesions in the disruption of prefronto-cerebellar loop in MwoA patients (Camarda et al., 2007) A PET study showed that migraine patients had significant hypometabolism in several areas such as Prefrontal Cortex and Anterior Cingulate Cortex (Kim et al., 2010)
21 Neuropsychological evaluation in MwoA patients mean SD Normal cut-off * Education (years) Global general cognition MMSE > 26/30 Psychiatric symptoms HARS < 14 HDRS < 10 Neuropsychological test TMT A TMT B WCST categories WCST err. perseveration WCST err. n. perseveration PF FAB
22 fmri results
23 Executive Network (Patients < Controls) R. Middle frontal gyrus R. Dorsal Anterior Cingulate Cortex
24 Discussion MwoA patients without executive dysfunction, in the interictal period, showed significant regional differences in distribution of executive-mode network components. There were no correlations between disturbances of FPN functional connectivity and clinical features such as age of disease onset, disease duration, frequency (day/month) and duration of migraine attack. Nevertheless, post-hoc analyses revealed that functional connectivity in the MFG was negatively correlated with the intensity of pain of migraine attacks (i.e. the higher the pain intensity, the lower the functional connectivity within FPN).
25 Neuropsychological evaluation L. Marcuccio Patients recruitment A. Giordano F. Conte F. d Onofrio proudly made in Napoli fmri data analysis A. Tessitore F. Esposito MRI data aquisition G. Taglialatela A. Paccone The Bosses J G. Tedeschi V. Bonavita
Supplementary Information Methods Subjects The study was comprised of 84 chronic pain patients with either chronic back pain (CBP) or osteoarthritis
Supplementary Information Methods Subjects The study was comprised of 84 chronic pain patients with either chronic back pain (CBP) or osteoarthritis (OA). All subjects provided informed consent to procedures
More informationcorrelates with social context behavioral adaptation.
REVIEW OF FRONTAL LOBE STRUCTURES Main organization of frontal cortex: 1. Motor area (precentral gyrus). 2. Premotor & supplementary motor areas (immediately anterior to motor area). Includes premotor,
More informationSUPPLEMENTARY MATERIAL. Table. Neuroimaging studies on the premonitory urge and sensory function in patients with Tourette syndrome.
SUPPLEMENTARY MATERIAL Table. Neuroimaging studies on the premonitory urge and sensory function in patients with Tourette syndrome. Authors Year Patients Male gender (%) Mean age (range) Adults/ Children
More informationInvestigations in Resting State Connectivity. Overview
Investigations in Resting State Connectivity Scott FMRI Laboratory Overview Introduction Functional connectivity explorations Dynamic change (motor fatigue) Neurological change (Asperger s Disorder, depression)
More informationFinal Report 2017 Authors: Affiliations: Title of Project: Background:
Final Report 2017 Authors: Dr Gershon Spitz, Ms Abbie Taing, Professor Jennie Ponsford, Dr Matthew Mundy, Affiliations: Epworth Research Foundation and Monash University Title of Project: The return of
More informationThe Frontal Lobes. Anatomy of the Frontal Lobes. Anatomy of the Frontal Lobes 3/2/2011. Portrait: Losing Frontal-Lobe Functions. Readings: KW Ch.
The Frontal Lobes Readings: KW Ch. 16 Portrait: Losing Frontal-Lobe Functions E.L. Highly organized college professor Became disorganized, showed little emotion, and began to miss deadlines Scores on intelligence
More informationQUANTIFYING CEREBRAL CONTRIBUTIONS TO PAIN 1
QUANTIFYING CEREBRAL CONTRIBUTIONS TO PAIN 1 Supplementary Figure 1. Overview of the SIIPS1 development. The development of the SIIPS1 consisted of individual- and group-level analysis steps. 1) Individual-person
More informationHuman Paleoneurology and the Evolution of the Parietal Cortex
PARIETAL LOBE The Parietal Lobes develop at about the age of 5 years. They function to give the individual perspective and to help them understand space, touch, and volume. The location of the parietal
More informationFrontal Contributions to Memory Encoding Before and After Unilateral Medial Temporal Lobectomy
Frontal Contributions to Memory Encoding Before and After Unilateral Medial Temporal Lobectomy Jeff Ojemann, MD Department of Neurological Surgery University of Washington Children s Hospital & Regional
More informationMigraine Does Not Affect Pain Intensity Perception: A Cross-Sectional Study
Pain Medicine 2018; 19: 1657 1666 doi: 10.1093/pm/pnx174 HEADACHE & FACIAL PAIN SECTION Brief Research Report Migraine Does Not Affect Pain Intensity Perception: A Cross-Sectional Study Antonio Russo,
More informationSupporting online material. Materials and Methods. We scanned participants in two groups of 12 each. Group 1 was composed largely of
Placebo effects in fmri Supporting online material 1 Supporting online material Materials and Methods Study 1 Procedure and behavioral data We scanned participants in two groups of 12 each. Group 1 was
More informationSupplementary information Detailed Materials and Methods
Supplementary information Detailed Materials and Methods Subjects The experiment included twelve subjects: ten sighted subjects and two blind. Five of the ten sighted subjects were expert users of a visual-to-auditory
More informationSupplementary Online Content
Supplementary Online Content Gregg NM, Kim AE, Gurol ME, et al. Incidental cerebral microbleeds and cerebral blood flow in elderly individuals. JAMA Neurol. Published online July 13, 2015. doi:10.1001/jamaneurol.2015.1359.
More informationfmri and Voxel-based Morphometry in Detection of Early Stages of Alzheimer's Disease
fmri and Voxel-based Morphometry in Detection of Early Stages of Alzheimer's Disease Andrey V. Sokolov 1,3, Sergey V. Vorobyev 2, Aleksandr Yu. Efimtcev 1,3, Viacheslav S. Dekan 1,3, Gennadiy E. Trufanov
More informationDefine functional MRI. Briefly describe fmri image acquisition. Discuss relative functional neuroanatomy. Review clinical applications.
Dr. Peter J. Fiester November 14, 2012 Define functional MRI. Briefly describe fmri image acquisition. Discuss relative functional neuroanatomy. Review clinical applications. Briefly discuss a few examples
More informationA possible mechanism for impaired joint attention in autism
A possible mechanism for impaired joint attention in autism Justin H G Williams Morven McWhirr Gordon D Waiter Cambridge Sept 10 th 2010 Joint attention in autism Declarative and receptive aspects initiating
More informationPrefrontal cortex and recognition memory Functional-MRI evidence for context-dependent retrieval processes
Brain (1998), 121, 1985 2002 Prefrontal cortex and recognition memory Functional-MRI evidence for context-dependent retrieval processes Anthony D. Wagner, 1 John E. Desmond, 1,2 Gary H. Glover 2 and John
More informationHow do individuals with congenital blindness form a conscious representation of a world they have never seen? brain. deprived of sight?
How do individuals with congenital blindness form a conscious representation of a world they have never seen? What happens to visual-devoted brain structure in individuals who are born deprived of sight?
More informationInterictal executive dysfunction in migraineurs without aura: relationship with duration and intensity of attacks
doi:10.1111/j.1468-2982.2007.01394.x Interictal executive dysfunction in migraineurs without aura: relationship with duration and intensity of attacks C Camarda*, R Monastero*, C Pipia, D Recca & R Camarda
More informationHallucinations and conscious access to visual inputs in Parkinson s disease
Supplemental informations Hallucinations and conscious access to visual inputs in Parkinson s disease Stéphanie Lefebvre, PhD^1,2, Guillaume Baille, MD^4, Renaud Jardri MD, PhD 1,2 Lucie Plomhause, PhD
More informationEst-ce que l'eeg a toujours sa place en 2019?
Est-ce que l'eeg a toujours sa place en 2019? Thomas Bast Epilepsy Center Kork, Germany Does EEG still play a role in 2019? What a question 7T-MRI, fmri, DTI, MEG, SISCOM, Of ieeg course! /HFO, Genetics
More informationChapter 14: The Cutaneous Senses
Chapter 14: The Cutaneous Senses Somatosensory System There are three parts Cutaneous senses - perception of touch and pain from stimulation of the skin Proprioception - ability to sense position of the
More informationDiagnosing Complicated Epilepsy: Mapping of the Epileptic Circuitry. Michael R. Sperling, M.D. Thomas Jefferson University Philadelphia, PA
Diagnosing Complicated Epilepsy: Mapping of the Epileptic Circuitry Michael R. Sperling, M.D. Thomas Jefferson University Philadelphia, PA Overview Definition of epileptic circuitry Methods of mapping
More informationProcedia - Social and Behavioral Sciences 159 ( 2014 ) WCPCG 2014
Available online at www.sciencedirect.com ScienceDirect Procedia - Social and Behavioral Sciences 159 ( 2014 ) 743 748 WCPCG 2014 Differences in Visuospatial Cognition Performance and Regional Brain Activation
More informationHST.583 Functional Magnetic Resonance Imaging: Data Acquisition and Analysis Fall 2008
MIT OpenCourseWare http://ocw.mit.edu HST.583 Functional Magnetic Resonance Imaging: Data Acquisition and Analysis Fall 2008 For information about citing these materials or our Terms of Use, visit: http://ocw.mit.edu/terms.
More informationSupplementary Online Content
Supplementary Online Content Green SA, Hernandez L, Tottenham N, Krasileva K, Bookheimer SY, Dapretto M. The neurobiology of sensory overresponsivity in youth with autism spectrum disorders. Published
More informationEffects Of Attention And Perceptual Uncertainty On Cerebellar Activity During Visual Motion Perception
Effects Of Attention And Perceptual Uncertainty On Cerebellar Activity During Visual Motion Perception Oliver Baumann & Jason Mattingley Queensland Brain Institute The University of Queensland The Queensland
More informationOverview of Questions
Overview of Questions What are the sensors in the skin, what do they respond to and how is this transmitted to the brain? How does the brain represent touch information? What is the system for sensing
More informationFDG-PET e parkinsonismi
Parkinsonismi FDG-PET e parkinsonismi Valentina Berti Dipartimento di Scienze Biomediche, Sperimentali e Cliniche Sez. Medicina Nucleare Università degli Studi di Firenze History 140 PubMed: FDG AND parkinsonism
More informationTable 1. Summary of PET and fmri Methods. What is imaged PET fmri BOLD (T2*) Regional brain activation. Blood flow ( 15 O) Arterial spin tagging (AST)
Table 1 Summary of PET and fmri Methods What is imaged PET fmri Brain structure Regional brain activation Anatomical connectivity Receptor binding and regional chemical distribution Blood flow ( 15 O)
More informationExperimental Design. Outline. Outline. A very simple experiment. Activation for movement versus rest
Experimental Design Kate Watkins Department of Experimental Psychology University of Oxford With thanks to: Heidi Johansen-Berg Joe Devlin Outline Choices for experimental paradigm Subtraction / hierarchical
More informationFunctional Neuroanatomy and Traumatic Brain Injury The Frontal Lobes
Functional Neuroanatomy and Traumatic Brain Injury The Frontal Lobes Jessica Matthes, Ph.D., ABN Barrow TBI Symposium March 23, 2019 jessica.matthes@dignityhealth.org Outline TBI Mechanisms of Injury Types
More informationCover Page. The handle holds various files of this Leiden University dissertation
Cover Page The handle http://hdl.handle.net/1887/39720 holds various files of this Leiden University dissertation Author: Hafkemeijer, Anne Title: Brain networks in aging and dementia Issue Date: 2016-05-26
More informationSupplementary Material S3 Further Seed Regions
Supplementary Material S3 Further Seed Regions Figure I. Changes in connectivity with the right anterior insular cortex. (A) wake > mild sedation, showing a reduction in connectivity between the anterior
More informationHEADACHE PATHOPHYSIOLOGY
HEADACHE PATHOPHYSIOLOGY Andrew Charles, M.D. Professor Director, UCLA Goldberg Migraine Program Meyer and Renee Luskin Chair in Migraine and Headache Studies Director, Headache Research and Treatment
More informationPosterior Cerebral Hypoperfusion in Migraine without Aura Marie Denuelle, MD Neurology Service, Rangueil Hospital Toulouse, France
Posterior Cerebral Hypoperfusion in Migraine without Aura Marie Denuelle, MD Neurology Service, Rangueil Hospital Toulouse, France Most of the cerebral blood flow (CBF) studies in migraine have introduced
More informationFactors and Clinical Management
Migraine and Cognitive Impairment: Risk Factors and Clinical Management Elizabeth K. Seng, Ph.D. Assistant Professor Ferkauf Graduate School of Psychology Saul R. Korey Department of Neurology Montefiore
More informationTwelve right-handed subjects between the ages of 22 and 30 were recruited from the
Supplementary Methods Materials & Methods Subjects Twelve right-handed subjects between the ages of 22 and 30 were recruited from the Dartmouth community. All subjects were native speakers of English,
More informationCognitive Neuroscience of Memory
Cognitive Neuroscience of Memory Types and Structure of Memory Types of Memory Type of Memory Time Course Capacity Conscious Awareness Mechanism of Loss Sensory Short-Term and Working Long-Term Nondeclarative
More informationWhat goes wrong with balance in Parkinson s Disease? Fay B Horak, PhD, PT Professor of Neurology Oregon Health and Science. CoM
What goes wrong with balance in Parkinson s Disease? Fay B Horak, PhD, PT Professor of Neurology Oregon Health and Science CoM CoM Course Objectives Understand different types of balance systems affected
More informationNeuroimaging in Clinical Practice
Neuroimaging in Clinical Practice John Gabrieli Department of Brain and Cognitive Sciences & Martinos Imaging Center at the McGovern Institute for Brain Research, MIT Disclosures Neither I nor my spouse/partner
More informationMotor Systems I Cortex. Reading: BCP Chapter 14
Motor Systems I Cortex Reading: BCP Chapter 14 Principles of Sensorimotor Function Hierarchical Organization association cortex at the highest level, muscles at the lowest signals flow between levels over
More informationResting-State Functional Connectivity in Stroke Patients After Upper Limb Robot-Assisted Therapy: A Pilot Study
Resting-State Functional Connectivity in Stroke Patients After Upper Limb Robot-Assisted Therapy: A Pilot Study N. Kinany 1,3,4(&), C. Pierella 1, E. Pirondini 3,4, M. Coscia 2, J. Miehlbradt 1, C. Magnin
More informationExperimental Design. Thomas Wolbers Space and Aging Laboratory Centre for Cognitive and Neural Systems
Experimental Design Thomas Wolbers Space and Aging Laboratory Centre for Cognitive and Neural Systems Overview Design of functional neuroimaging studies Categorical designs Factorial designs Parametric
More informationUse of Multimodal Neuroimaging Techniques to Examine Age, Sex, and Alcohol-Related Changes in Brain Structure Through Adolescence and Young Adulthood
American Psychiatric Association San Diego, CA 24 May 2017 Use of Multimodal Neuroimaging Techniques to Examine Age, Sex, and Alcohol-Related Changes in Brain Structure Through Adolescence and Young Adulthood
More informationCerebral Cortex 1. Sarah Heilbronner
Cerebral Cortex 1 Sarah Heilbronner heilb028@umn.edu Want to meet? Coffee hour 10-11am Tuesday 11/27 Surdyk s Overview and organization of the cerebral cortex What is the cerebral cortex? Where is each
More informationCognitive dysfunctions and psychological symptoms in migraine without aura: a cross-sectional study
Santangelo et al. The Journal of Headache and Pain (2016) 17:76 DOI 10.1186/s10194-016-0667-0 The Journal of Headache and Pain RESEARCH ARTICLE Open Access Cognitive dysfunctions and psychological symptoms
More informationSource Memory is not Properly Differentiated from Object Memory in Early Schizophrenia An fmri study using virtual reality
Source Memory is not Properly Differentiated from Object Memory in Early Schizophrenia An fmri study using virtual reality Colin S. Hawco, PhD Lisa Buchy Michael Bodnar, Sarah Izadi, Jennifer Dell Elce,
More informationEvaluating the roles of the basal ganglia and the cerebellum in time perception
Sundeep Teki Evaluating the roles of the basal ganglia and the cerebellum in time perception Auditory Cognition Group Wellcome Trust Centre for Neuroimaging SENSORY CORTEX SMA/PRE-SMA HIPPOCAMPUS BASAL
More informationMade you look! Consciously perceived, irrelevant instructional cues can hijack the. attentional network
Made you look! Consciously perceived, irrelevant instructional cues can hijack the attentional network Katherine Sledge Moore, Clare B. Porter, and Daniel H. Weissman Department of Psychology, University
More informationHST.583 Functional Magnetic Resonance Imaging: Data Acquisition and Analysis Fall 2008
MIT OpenCourseWare http://ocw.mit.edu HST.583 Functional Magnetic Resonance Imaging: Data Acquisition and Analysis Fall 2008 For information about citing these materials or our Terms of Use, visit: http://ocw.mit.edu/terms.
More informationDuplex Theory of Texture Perception
Duplex Theory of Texture Perception Katz (1925) proposed that perception of texture depends on two cues: Spatial cues are determined by the size, shape, and distribution of surface elements Temporal cues
More informationChanges in Default Mode Network as Automaticity Develops in a Categorization Task
Purdue University Purdue e-pubs Open Access Theses Theses and Dissertations January 2015 Changes in Default Mode Network as Automaticity Develops in a Categorization Task Farzin Shamloo Purdue University
More informationChapter 2 Test. 1. Evolutionary structures within the are the most primitive. *a. hindbrain b. thalamus c. forebrain d. midbrain e.
Cognitive Psychology In and Out of the Laboratory 5th Edition Galotti TEST BANK Full clear download (no formatting errors) at: https://testbankreal.com/download/cognitive-psychology-laboratory-5thedition-galotti-test-bank/
More informationSummary of my talk. Cerebellum means little brain but a huge neural resource. Studying the cerebellum in. Chris Miall
Studying the cerebellum in sensory motor control Chris Miall Behavioural Brain Sciences School of Psychology University of Birmingham Summary of my talk Cerebellum means little brain but a huge neural
More informationThe neural correlates of visuo-spatial working memory in children with autism spectrum disorder: effects of cognitive load
Vogan et al. Journal of Neurodevelopmental Disorders 2014, 6:19 RESEARCH Open Access The neural correlates of visuo-spatial working memory in children with autism spectrum disorder: effects of cognitive
More informationBrain Imaging Applied to Memory & Learning
Brain Imaging Applied to Memory & Learning John Gabrieli Department of Brain & Cognitive Sciences Institute for Medical Engineering & Sciences McGovern Institute for Brain Sciences MIT Levels of Analysis
More informationFunctional topography of a distributed neural system for spatial and nonspatial information maintenance in working memory
Neuropsychologia 41 (2003) 341 356 Functional topography of a distributed neural system for spatial and nonspatial information maintenance in working memory Joseph B. Sala a,, Pia Rämä a,c,d, Susan M.
More informationTHE PREFRONTAL CORTEX. Connections. Dorsolateral FrontalCortex (DFPC) Inputs
THE PREFRONTAL CORTEX Connections Dorsolateral FrontalCortex (DFPC) Inputs The DPFC receives inputs predominantly from somatosensory, visual and auditory cortical association areas in the parietal, occipital
More informationMathematical models of visual category learning enhance fmri data analysis
Mathematical models of visual category learning enhance fmri data analysis Emi M Nomura (e-nomura@northwestern.edu) Department of Psychology, 2029 Sheridan Road Evanston, IL 60201 USA W Todd Maddox (maddox@psy.utexas.edu)
More informationChapter 3 Long-term effects of frequent cannabis use on working memory and attention: an fmri study
Chapter 3 Long-term effects of frequent cannabis use on working memory and attention: an fmri study Gerry Jager, René S. Kahn, Wim van den Brink, Jan M. van Ree, Nick F. Ramsey Psychopharmacology, 2006,
More informationSupplemental Data. Inclusion/exclusion criteria for major depressive disorder group and healthy control group
1 Supplemental Data Inclusion/exclusion criteria for major depressive disorder group and healthy control group Additional inclusion criteria for the major depressive disorder group were: age of onset of
More informationP. Hitchcock, Ph.D. Department of Cell and Developmental Biology Kellogg Eye Center. Wednesday, 16 March 2009, 1:00p.m. 2:00p.m.
Normal CNS, Special Senses, Head and Neck TOPIC: CEREBRAL HEMISPHERES FACULTY: LECTURE: READING: P. Hitchcock, Ph.D. Department of Cell and Developmental Biology Kellogg Eye Center Wednesday, 16 March
More informationThe missing link: Enhanced functional connectivity between amygdala and visceroceptive cortex in migraine
Brief Report The missing link: Enhanced functional connectivity between amygdala and visceroceptive cortex in migraine Cephalalgia 33(15) 1264 1268! International Headache Society 2013 Reprints and permissions:
More informationMEG Coherence Imaging of Low frequencies: Applications for Stroke and Migraine & DC shifts in spreading cortical depression. Susan M.
MEG Coherence Imaging of Low frequencies: Applications for Stroke and Migraine & DC shifts in spreading cortical depression Susan M. Bowyer PhD John Moran PhD, Karen M Mason R.EEG/MEG T, Brien J Smith
More informationData Analysis. Memory and Awareness in Fear Conditioning. Delay vs. Trace Conditioning. Discrimination and Reversal. Complex Discriminations
What is Fear Conditioning? Memory and Awareness in Fear Conditioning Information and prediction: Animals use environmental signals to predict the occurrence of biologically significant events. Similar
More informationTest Bank. Multiple Choice
Chapter 2: The Brain: An Overview of Structure and Function Test Bank Multiple Choice 1. Evolutionary structures within the are the most primitive. a. hindbrain b. thalamus c. forebrain d. midbrain Answer
More informationCase reports functional imaging in epilepsy
Seizure 2001; 10: 157 161 doi:10.1053/seiz.2001.0552, available online at http://www.idealibrary.com on Case reports functional imaging in epilepsy MARK P. RICHARDSON Medical Research Council Fellow, Institute
More informationSUPPLEMENT: DYNAMIC FUNCTIONAL CONNECTIVITY IN DEPRESSION. Supplemental Information. Dynamic Resting-State Functional Connectivity in Major Depression
Supplemental Information Dynamic Resting-State Functional Connectivity in Major Depression Roselinde H. Kaiser, Ph.D., Susan Whitfield-Gabrieli, Ph.D., Daniel G. Dillon, Ph.D., Franziska Goer, B.S., Miranda
More informationTears of Pain SUNCT and SUNA A/PROFESSOR ARUN AGGARWAL RPAH PAIN MANAGEMENT CENTRE
Tears of Pain SUNCT and SUNA A/PROFESSOR ARUN AGGARWAL RPAH PAIN MANAGEMENT CENTRE IHS Classification 1989 (updated 2004) Primary Headaches 4 categories Migraine Tension-type Cluster and other trigeminal
More informationCombining tdcs and fmri. OHMB Teaching Course, Hamburg June 8, Andrea Antal
Andrea Antal Department of Clinical Neurophysiology Georg-August University Goettingen Combining tdcs and fmri OHMB Teaching Course, Hamburg June 8, 2014 Classical Biomarkers for measuring human neuroplasticity
More informationGoal-directed Thought
2006 Summer School, Sofia, Bulgaria Cognitive Neuroscience of Thought Kalina Christoff Goal-directed Thought The Contribution of ateral Prefrontal Cortex How do we think about goal-directed thought? A
More informationReading Words and Non-Words: A Joint fmri and Eye-Tracking Study
Reading Words and Non-Words: A Joint fmri and Eye-Tracking Study A N N - M A R I E R A P H A I L S R E B C S, S K I D M O R E C O L L E G E D R. J O H N H E N D E R S O N U N I V E R S I T Y O F S O U
More informationLearning Objectives.
Emilie O Neill, class of 2016 Learning Objectives 1. Describe the types of deficits that occur with lesions in association areas including: prosopagnosia, neglect, aphasias, agnosia, apraxia 2. Discuss
More informationAuditory Processing Of Schizophrenia
Auditory Processing Of Schizophrenia In general, sensory processing as well as selective attention impairments are common amongst people with schizophrenia. It is important to note that experts have in
More informationTask-induced deactivations during successful paired associates learning: An effect of age but not Alzheimer s disease
www.elsevier.com/locate/ynimg NeuroImage 31 (2006) 818 831 Task-induced deactivations during successful paired associates learning: An effect of age but not Alzheimer s disease Rebecca L. Gould, a, * Richard
More informationFINAL PROGRESS REPORT
(1) Foreword (optional) (2) Table of Contents (if report is more than 10 pages) (3) List of Appendixes, Illustrations and Tables (if applicable) (4) Statement of the problem studied FINAL PROGRESS REPORT
More informationThe Neural Correlates of Moral Decision-Making in Psychopathy
University of Pennsylvania ScholarlyCommons Neuroethics Publications Center for Neuroscience & Society 1-1-2009 The Neural Correlates of Moral Decision-Making in Psychopathy Andrea L. Glenn University
More informationASSESSING MULTISENSORY INTEGRATION WITH ADDITIVE FACTORS AND FUNCTIONAL MRI
ASSESSING MULTISENSORY INTEGRATION WITH ADDITIVE FACTORS AND FUNCTIONAL MRI Thomas W. James, Ryan A. Stevenson and Sunah Kim Department of Psychological and Brain Sciences, Indiana University, 1101 E Tenth
More informationCSE511 Brain & Memory Modeling Lect 22,24,25: Memory Systems
CSE511 Brain & Memory Modeling Lect 22,24,25: Memory Systems Compare Chap 31 of Purves et al., 5e Chap 24 of Bear et al., 3e Larry Wittie Computer Science, StonyBrook University http://www.cs.sunysb.edu/~cse511
More informationIs mindfulness meditation an appropriate therapy in patients presenting with chronic pain?
Is mindfulness meditation an appropriate therapy in patients presenting with chronic pain? Background Chronic pain affects between one-third and one-half of the UK adult 10.4% to 14.3% of cases being moderate-severely
More informationVIII. 10. Right Temporal-Lobe Contribution to the Retrieval of Family Relationships in Person Identification
CYRIC Annual Report 2009 VIII. 10. Right Temporal-Lobe Contribution to the Retrieval of Family Relationships in Person Identification Abe N. 1, Fujii T. 1, Ueno A. 1, Shigemune Y. 1, Suzuki M. 2, Tashiro
More informationNeuroimaging of ADHD and Executive Functions
Neuroimaging of ADHD and Executive Functions John Gabrieli Department of Brain and Cognitive Sciences & Martinos Imaging Center at the McGovern Institute for Brain Research, MIT Disclosures Neither I nor
More informationSupplementary Online Content
Supplementary Online Content Van Laere K, Vanhee A, Verschueren J, et al. Value of 18 fluorodeoxyglucose positron-emission tomography in amyotrophic lateral sclerosis. JAMA Neurol. Published online March
More informationBINGES, BLUNTS AND BRAIN DEVELOPMENT
BINGES, BLUNTS AND BRAIN DEVELOPMENT Why delaying the onset of alcohol and other drug use during adolescence is so important Aaron White, PhD Division of Epidemiology and Prevention Research National Institute
More informationSupporting Information
Revisiting default mode network function in major depression: evidence for disrupted subsystem connectivity Fabio Sambataro 1,*, Nadine Wolf 2, Maria Pennuto 3, Nenad Vasic 4, Robert Christian Wolf 5,*
More informationThe Central Nervous System
The Central Nervous System Cellular Basis. Neural Communication. Major Structures. Principles & Methods. Principles of Neural Organization Big Question #1: Representation. How is the external world coded
More informationSupplementary materials. Appendix A;
Supplementary materials Appendix A; To determine ADHD diagnoses, a combination of Conners' ADHD questionnaires and a semi-structured diagnostic interview was used(1-4). Each participant was assessed with
More informationHigher Cortical Function
Emilie O Neill, class of 2016 Higher Cortical Function Objectives Describe the association cortical areas processing sensory, motor, executive, language, and emotion/memory information (know general location
More informationTiming & Schizophrenia. Deana Davalos Colorado State University
Timing & Schizophrenia Deana Davalos Colorado State University What is Temporal Processing? (Thank you to all for background) In everyday terms Can I cross the street without being hit by a car? Do I have
More informationSPECIAL ISSUE: ORIGINAL ARTICLE BINDING OF WHAT AND WHERE DURING WORKING MEMORY MAINTENANCE
SPECIAL ISSUE: ORIGINAL ARTICLE BINDING OF WHAT AND WHERE DURING WORKING MEMORY MAINTENANCE Joseph B. Sala 1,2 and Susan M. Courtney 3,4,5 ( 1 Psychology Department, Stanford University, Stanford, CA,
More informationSupplementary Material. Functional connectivity in multiple cortical networks is associated with performance. across cognitive domains in older adults
Supplementary Material Functional connectivity in multiple cortical networks is associated with performance across cognitive domains in older adults Emily E. Shaw 1,2, Aaron P. Schultz 1,2,3, Reisa A.
More informationEDGE DETECTION. Edge Detectors. ICS 280: Visual Perception
EDGE DETECTION Edge Detectors Slide 2 Convolution & Feature Detection Slide 3 Finds the slope First derivative Direction dependent Need many edge detectors for all orientation Second order derivatives
More informationDecision-making deficit in chronic migraine patients with medication overuse
DOI 10.1007/s10072-012-1071-4 ORAL COMMUNICATIONS Decision-making deficit in chronic migraine patients with medication overuse B. Biagianti L. Grazzi O. Gambini S. Usai R. Muffatti S. Scarone G. Bussone
More informationSupporting Information
Supporting Information Moriguchi and Hiraki 10.1073/pnas.0809747106 SI Text Differences in Brain Activation Between Preswitch and Postswitch Phases. The paired t test was used to compare the brain activation
More informationCh 5. Perception and Encoding
Ch 5. Perception and Encoding Cognitive Neuroscience: The Biology of the Mind, 2 nd Ed., M. S. Gazzaniga, R. B. Ivry, and G. R. Mangun, Norton, 2002. Summarized by Y.-J. Park, M.-H. Kim, and B.-T. Zhang
More informationPharmacologyonline 3: (2010)
PERSEVERATIONS IN ALZHEIMER DISEASE: ANALYSIS OF THE DISTURBANCE AND POSSIBLE CORRELATIONS M. D Antonio¹, L. Trojano², M. R. De Riso², D. Grossi ² and A. M. Fasanaro¹, ¹Alzheimer Unit, Neurology Department,
More informationAuditory fmri correlates of loudness perception for monaural and diotic stimulation
PROCEEDINGS of the 22 nd International Congress on Acoustics Psychological and Physiological Acoustics (others): Paper ICA2016-435 Auditory fmri correlates of loudness perception for monaural and diotic
More informationBrain Imaging studies in substance abuse. Jody Tanabe, MD University of Colorado Denver
Brain Imaging studies in substance abuse Jody Tanabe, MD University of Colorado Denver NRSC January 28, 2010 Costs: Health, Crime, Productivity Costs in billions of dollars (2002) $400 $350 $400B legal
More informationFUNCTIONAL MRI IN EPILEPSY December 6 th 2013
FUNCTIONAL MRI IN EPILEPSY December 6 th 2013 Matthias J Koepp, MD, PhD UCL Institute of Neurology National Hospital for Neurology and Neurosurgery London, UK American Epilepsy Society Annual Meeting Disclosure
More information