Hemophilia and Bleeding Disorders
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1 Hemophilia and Bleeding Disorders August 16, 2018 Presented by Trinna Bloomquist, RN, BSN Personal Health Partner Mary Bridge Children s Hematology/Oncology Content provided in partnership with: Barbara Corwin Oldenburger, RN, BSN Bloodworks NW 1
2 Quick view Hemostasis: 1. Injury to blood vessel 2. Injured vessel constriction 3. Tissue factor activates platelets 4. Von Willebrand protein binds them together and to collagen 5. Clotting Cascade to convert fibrinogen to fibrin, a mesh or band aid 6. Vessel and tissue heals, pulls together 7. Clot torn down by fibrinolytic enzymes 2
3 When something goes wrong. Von Willebrand Disease: insufficient or ineffective Von Willebrand factor Hemophilia A: Missing or insufficient quantity of Factor VIII protein Hemophilia B: Missing or insufficient quantity of Factor IX protein 3
4 Incidence of Hemophilia: 1 in 5000 Males has Hemophilia A 1 in 10,000 Males has Hemophilia B Inherited, X linked recessive disorder Expressed in males carried in females Severity level is consistent between family members Affects all races/ethnic groups equally 4
5 Incidence of Von Willebrand 1/100 men and women effected equally (CDC) Type 1: most common (85%); not enough VW Type 2 functional issue with VW protein Type 3 most severe, little or no VWF, causes secondary factor VIII deficiency; incidence 1/500,000-1,000,000 5
6 Von Willebrand cont. Interesting fine points: Difficulty in testing: VWf an acute phase reactantdistress during lab draws, crying, pain, fear, stress etc. Effected by hormone fluctuations menstrual cycle By third trimester production of factor VIII and VWf triples in production and falls back to previous baseline levels within hours after delivery 6
7 Hemophilia Severe: activity level is less than 1% at risk for spontaneous bleeding: ICH, joint bleeds, muscle bleeds Moderate: factor activity level is less than 1-5% bleeds with injury or invasive procedures Mild: factor VIII or Factor IX activity level is 6-30% bleeds with injury or invasive procedures AS COMPARED TO NORMAL LEVELS % 7
8 Most people have 100% of the ingredients in their clotting system that lets them make the band-aids they need. Hemophilia A is like missing the flour, Hemophilia B is like missing the sugar. Either way, you re missing the ingredients to make a strong band aid 8
9 What Bleeding Looks Like in Kids with Hemophilia Deep bleeding into joints and muscles Can t see it until late stage of bleeding Bruises can look impressive but not the big worry Classic hemophilia bruise will have a knot in the center Joints will become warm and swollen The sooner a child is treated, normalizing their factor activity levels, the sooner the bleed is cleaned up and less overall factor will be required in the long run A boy with hemophilia doesn t bleed faster than other kids, but he bleeds longer Effects of repetitive bleeding into joint space-hemarthrosis 9
10 What Bleeding Looks Like in Kids with Von Willebrand Disease MUCOTANEOUS BLEEDING Nosebleeds Mouth bleeds Trouble with even minor surgeries Girls: menorrhagia Severity depends on type of Von Willebrand 10
11 Joint Bleeds Most Common Bleed in Hemophilia Knees, Hips, Ankles, Shoulders, Elbows May be caused by trauma or can be spontaneous in severe hemophilia No early visible signs (i.e. no bruising) Tingling, bubbling warm sensation Pain: Limping, favoring Late signs: swelling, firm, flexed R.I.C.E. Ice Ice Ice Ice Ice Ice Factor Infusion as soon as possible Synovium damage 11
12 Muscle Bleeds Second most common bleeding issue in hemophilia Large muscles can = blood volume loss Compartment Syndrome Contractures Goal: raise FACTOR level to normal 100% and not let it fall below 50% R.I.C.E. Ice Ice Ice Ice Ice Ice Several days of treatment, can take much longer than a joint bleed to heal 12
13 Other Bleeding Minor Injuries Bruising Mouth bleeds Nosebleeds Scrapes First aid Potential Emergent Head Injuries Eye Injury Airway Trauma GI Bleed Iliospoas Bleed Other uncontrolled bleeding (i.e. menorrhagia etc) 13
14 Call to Triage Bleeding Issues: 1. If a child is unconscious, call as you would for any other student. 2. Call Parents. 3. Call Mary Bridge Children s Hematology Clinic at M-F, 8am-4pm. Remember, a boy with hemophilia is not going to bleed faster than other children, but longer. 14
15 Factor Infusion Infusion Skills: Port-a-cath training of parents PIV skills kids ages 7 and up are taught venous access Camp IVY Dose is based on assays +/- 10% 15
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17 Sports and Play: kids need to be kids Importance of Physical Activity Strong muscles protect joints Social No contact sports Prophylaxis before Ice Learning to self infuse Medical Alert Education with coaches, communication with parents 17
18 Hemophilia Treatment Center (HTC) of Washington Washington Center for Bleeding Disorders BloodworksNW Pharmacy Mary Bridge Children s Health Center Seattle Children s Medical Center Sacred Heart Medical Center Research Outreach Camp 340B Comprehensive care for rare bleeding disorders 18
19 Hemophilia at School: A regular kid with a bleeding disorder What do school personnel need to know most? Blood disorders are treatable and most bleeding problems preventable. The key is communication with the child and parent. Though a bump may seem minor, the internal bleed can show up later. It s important to start treatment early on and report all school incidents to parents. Always believe a child when he says he has a bleed. 19
20 Hemophilia at School: A regular kid with a bleeding disorder What is Hemophilia? Hemophilia is a disorder of the clotting system mostly affecting boys. They lack a protein required to stabilize a blood clot. Kids with hemophilia don t bleed faster, they bleed longer. There are two main types of hemophilia based on the protein that is either missing or low, either clotting protein factor 8 (Hemophilia A) or clotting protein factor 9 (Hemophilia B). A lack of either one of these proteins causes hemophilia. Some people with hemophilia make a little bit of the clotting factor, some make none. The symptoms and severity of hemophilia depend on how much clotting factor is missing. 20
21 Hemophilia at School: A regular kid with a bleeding disorder Are there any activity restrictions for this child? It is every child s job to explore, test their strength, socialize through play and organized activities, and simply be a child. We want kids with bleeding disorders to be healthy and active which means pursuing all kinds of sports and activities. We understand that there is no way to ensure that a child won t ever get hurt. However, some sports are just not worth the risks that they bring. For example, intentionally high impact contact sports such as contact football, wrestling, hockey, lacrosse, are advised against since the risks outweigh the benefits. 21
22 Common first aid needs Most children with bleeding disorders respond to general first aid like any other child would. Treat minor scrapes and bruises like you would any other child. R.I.C.E. = Rest Ice Compression Elevation, is advised. Do not apply warm packs to a child with bruising or warm drink to child with a mouth bleed. Early intervention is very important: Rest the injured area. If moving the injured area causes pain, this is the body's way of saying stop. Rest the affected area. Do not use or bear weight (such as standing or walking). Ice packs to the injured area will help to prevent or reduce swelling. Swelling causes more pain and can slow healing. Apply a cloth-covered ice pack to the injured area for no more than 20 minutes at a time, 4 to 8 times a day. Compression (i.e. use of an ace wrap) also helps to prevent or reduce swelling. Wrap the injured area with an ace bandage snuggly but not tight. It should not hurt or throb. Fingers or toes beyond the bandage should remain pink and not become "tingly." The ace wrap should be taken off every 4 hours and reapplied. Elevation means raising the injured area above the level of the heart. The affected part should be elevated so it is 12 inches above the heart, to help reduce swelling. 22
23 Problem: Bruising Nose bleeds Cuts and scrapes Mouth bleeds Menorrhagia (painful menstruation) Head injury Throat neck injury Stomach/abdominal injury Fever Recommendation R.I.C.E. May not need intervention if not painful. Call parent if hematoma is forming or if bruising affects movement of extremity Wear gloves. Tilt head forward, pinch nose minutes. Call parent if heavy bleeding does not stop after 15 minutes Wear gloves. Clean with soap/water as per school protocol Wear gloves. Apply direct pressure with gauze. Tongue cuts can be more serious. Give cold items like ice or popsicle. Call parent if bleeding does not stop. Girls should be excused from PE class temporarily as necessary. Contact parent if necessary. Call 911 for loss of consciousness, nausea, vomiting, severe pain, blurred vision or sleepiness. Notify parent immediately of any head trauma. Call 911 for any breathing trouble due to trauma to neck. Call parent right away for any trauma to throat or neck injury. Internal bleeds to neck area can be serious. Call parent. Watch for skin color changes, rigidity of the abdomen, increased pulse, decreased blood pressure. If a child has a central line, call parent immediately for ANY fever. 23
24 CENTRAL LINE: YES No Type (A central line is an IV catheter placed into an arm or chest used to give medicines.) Hemophilia Factor replacement can only be administered by a trained persons. Due to complexity of mixing and administering, specific requirements for storage, expiration time of medication, and extreme cost of the medication, factor should not be stored at school, even for the emergency 3 day supply. If factor is needed, the family should be notified and will determine if 911 should be called to transport the patient or if it can wait until the family can arrive with factor.! CALL 911 FOR BREATHING TROUBLE OR LOSS OF CONSCIOUSNESS! Call parents or emergency contacts right away when the student has symptoms such as: 1. Unable to stop bleeding 2. Fever over F 3. Any trauma to head 4. If child is complaining of any pain that could indicate bleeding 5. Other: 24
25 Signs and Symptoms of bleeding: A. Child reports tingling, warmth, swelling or guarding B. Arm or leg held in an abnormal position C. Obvious signs of discomfort or pain D. Area of bleed is warm to touch E. Swelling (a late sign of a bleed) F. Firmness and tenderness on palpation G. Restriction of all range of motion indicates bleeding within a joint Signs and symptoms of infection of a central line: A. Fever greater than F B. Redness, swelling, pain or draining of port (central line) site 25
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