Vance Thompson, MD Sioux Falls, South Dakota. Eyecare s Most Revolutionary Optical Solution

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Patrick Warren
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1 Vance Thompson, MD Sioux Falls, South Dakota Eyecare s Most Revolutionary Optical Solution

2 Financial Disclosures Acufocus: Consultant/Research Alcon Laboratories: Consultant/Research Allergan: Consultant/Research Allotex: Consultant/Advisor Avellino: Consultant Bausch and Lomb: Consultant/Advisor/Research BRIM Biotechnology, Inc: Consultant Carl Zeiss Meditec: Consultant/Research Conjtac: Consultant/Advisory/Equity Owner CSO: Consultant Equinox: Consultant/Investor Euclid Systems: Consultant eyebrain Medical Inc: Equity Owner Eyedetec: Consultant EyeGate Pharma: Consultant Healthe: Consultant Imprimis: Consultant/Advisor Johnson and Johnson: Consultant/Research Mynosys: Consultant/Advisor/Research Novaliq: Consultant OPHTECH: Consultant Oyster Point Pharma: Consultant Precision Lens: Consultant RxSight: Consultant SightSciences: Consultant Stuart Therapeutics: Consultant Tarsus Rx: Consultant TearClear: Consultant ThruFocus: Consultant Treehouse Health: Consultant/Advisor/Equity Owner Veracity: Consultant Visant: Consultant Visiometrics: Consultant Vivor AG: Consultant

5 Artificial Tears Restasis Xiidra Punctal Plugs

6 Artificial Tears Restasis Xiidra Punctal Plugs

7 Revolutionary Dry Eye Drug/Treatment

8 Revolutionary Dry Eye Drug/Treatment

9 Revolutionary Dry Eye Drug/Treatment

10 Revolutionary Dry Eye Drug/Treatment Phantom Dry Eye

11 Revolutionary Dry Eye Drug/Treatment Phantom Dry Eye

13 Dramatic Shift in Near Tasks! Millions of Units E 2013E 2014E 2015E 2016E Tablets Smartphones Personal Computers

14 Digital Vision Syndrome 65% of Americans Neck/shoulder/back pain Symptoms Reported 36% Eye strain 35% Headache 25% Blurred vision 25% Dry eyes 24% according to the Vision Council 2016 report

16 Headache Types Migraine without Aura Migraine with Aura: Tension Type Headache Medication overuse headache

17 Headache Types Migraine without Aura Migraine with Aura: Tension Type Headache Medication overuse headache Constant headache Dry eye sensation Light sensitive

18 Headache Types Migraine without Aura Migraine with Aura: Tension Type Headache Medication overuse headache Constant headache Dry eye sensation Light sensitive Worse with reading and working on the computer

19 Headache Types Migraine without Aura Migraine with Aura: Tension Type Headache Medication overuse headache Trigeminal Dysphoria Headache Constant headache Dry eye sensation Light sensitive Worse with reading and working on the computer

22 2 patients with horrible dry eye symptoms One Myopic LASIK One Cataract Implant

23 2 patients with horrible dry eye symptoms One Myopic LASIK One Cataract Implant look dry test dry response to dry eye therapy

24 2 patients with horrible dry eye symptoms One Myopic LASIK One Cataract Implant With these glasses my dry eye feeling is gone

26 Hey Buddy

28 Comfortable alignment

29 Un-Comfortable alignment

30 Prolonged Work

31 Prolonged Work

34 Trigeminal Nerve Over-Stimulation: Dry Eyes Eye Strain Headache

35 Trigeminal Nerve Over-Stimulation: Dry Eyes Eye Strain Headache Trigeminal Dysphoria

36 Trigeminal Dysphoria Symptoms Stiffness/pain in neck/shoulders Tired Eyes Light Sensitivity Headache Dizziness Discomfort with Computer Use Dry Eye Sensation

37 Hope

38 A. E. Turviille

41 The Problem: Near Vision Demands

42 Clinical Benefit of Contoured Prism? Distance Intermediate Near Distance Intermediate Near

43 Clinical Benefit of Contoured Prism? Distance Intermediate Near Distance Intermediate Near

44 Clinical Benefit of Contoured Prism? Distance Intermediate Near Distance Intermediate Near

48 Buddy we need to automate this measurement to catapult A. E. it Turviille into this day and age

49 Andy and Davis Corley

50 Revolutionary Technology

51 neurolens Device: different from traditional testing

52 neurolens Device : different from traditional testing

53 neurolens Value Range neurolens Value Range:

54 neurolens

55 Exciting Data!

56 Digital Vision Syndrome (DVS) Study Patient Reported Symptom Relief 90 Day 22 participants inclusion criteria = Qualified as DVS sufferer by validated questionnaire 1 100% positive response to treatment at 90 days 86% reported DVS symptoms as Reduced Substantially or Basically Gone How have your symptoms responded? n=22 14% 59% 27% Basically Gone Decreased Substantially Decreased Slightly No Change Increased 1. Maria del Mar Segui, Journal of Clinical Epidemiology, 68 ( )

57 Digital Vision Syndrome (DVS) Study Patient Reported Symptom Relief 90 Day 22 participants inclusion criteria = Qualified as DVS sufferer by validated questionnaire 1 100% positive response to treatment at 90 days 86% reported DVS symptoms as Reduced Substantially or Basically Gone How have your symptoms responded? n=22 14% 59% 27% Basically Gone Decreased Substantially Decreased Slightly No Change Increased 1. Maria del Mar Segui, Journal of Clinical Epidemiology, 68 ( )

58 Chronic Daily Headache Study Patient Reported Symptom Relief 90 Day 179 participants inclusion criteria = refractory, end-of-line chronic headache 81.6% positive response to treatment at 90 days 54% reported headache symptoms as Reduced Substantially or Basically Gone How have your symptoms responded? n=179 17% 24% 13% 41% Basically Gone Decreased Substantially Decreased Slightly No Change Increased

59 Chronic Daily Headache Study Patient Reported Symptom Relief 90 Day 179 participants inclusion criteria = refractory, end-of-line chronic headache 81.6% positive response to treatment at 90 days 54% reported headache symptoms as Reduced Substantially or Basically Gone How have your symptoms responded? n=179 17% 24% 13% 41% Basically Gone Decreased Substantially Decreased Slightly No Change Increased

60 neurolens users 70.00% 60.00% 50.00% 40.00% Symptomatic response to treatment n = % 93% of patients have responded positively to wearing neurolenses after purchasing 60.0% 50.0% 40.0% 30.0% 56.4% Willingness to Recommend n = % 82.5% of patients are willing to recommend neurolens technology after purchasing 30.00% 20.00% 15.3% 20.0% 20.0% 12.2% 10.00% 6.7% 0.6% 10.0% 3.6% 1.7% 0.00% Basically Gone Decreased Substantially Decreased Slightly Unchanged Increased 0.0% Strongly Agree Agree Not Sure Disagree Strongly Disagree

61 neurolens users 70.00% 60.00% 50.00% 40.00% Symptomatic response to treatment n = % 93% of patients have responded positively to wearing neurolenses after purchasing 60.0% 50.0% 40.0% 30.0% 56.4% Willingness to Recommend n = % 82.5% of patients are willing to recommend neurolens technology after purchasing 30.00% 20.00% 15.3% 20.0% 20.0% 12.2% 10.00% 6.7% 0.6% 10.0% 3.6% 1.7% 0.00% Basically Gone Decreased Substantially Decreased Slightly Unchanged Increased 0.0% Strongly Agree Agree Not Sure Disagree Strongly Disagree

62 neurolens users 70.00% 60.00% 50.00% 40.00% Symptomatic response to treatment n = % 93% of patients have responded positively to wearing neurolenses after purchasing 60.0% 50.0% 40.0% 30.0% 56.4% Willingness to Recommend n = % 82.5% of patients are willing to recommend neurolens technology after purchasing 30.00% 20.00% 15.3% 20.0% 20.0% 12.2% 10.00% 6.7% 0.6% 10.0% 3.6% 1.7% 0.00% Basically Gone Decreased Substantially Decreased Slightly Unchanged Increased 0.0% Strongly Agree Agree Not Sure Disagree Strongly Disagree

63 Population Study Confirms Size & Severity of Problem Trigeminal Dysphoria Index FOR PATIENT USE Lifestyle Index PT INITIALS This survey is meant to help your doctor understand what you re experiencing on a regular basis whether it s caused by your eyes, posture, stress, etc. Your responses will help make sure you receive the best care possible. DATE FOR OFFICE USE 2017 Population study of eye exams How often do you experience any of these symptoms? Circle one: Headaches Stiffness / pain in neck / shoulders You get headaches of any severity each week (even just a dull ache counts). Your headaches tend to get worse later in the day. Your headaches are generally worse at work than they are at home or on weekends. 1 Never Your neck gets stiff and sore when you work at a computer or read (This might even be from your posture). You experience frequent tension in your head, neck or shoulders. You get frequent massages/chiropractic adjustments. 1 Never 2 Rarely 2 Rarely 3 Sometimes 3 Sometimes 4 Very Often 4 Very Often 5 Always 5 Always Discomfort with Computer Use You feel like you are more productive at work in the morning vs. the afternoon. Your eyes get tired, burn, or get red easily when you work at a computer for long hours. 1 Never 2 Rarely 3 Sometimes 4 Very Often 5 Always Number of hours per day using a digital device: Tired Eyes Your eyes feel fatigued/tired at the end of a workday. Your eyes generally feel better in the morning compared to the end of the day. 1 Never 2 Rarely 3 Sometimes 4 Very Often 5 Always Dry Eye Sensation Light Sensitivity Your eyes and/or contacts tend to dry out when you are working at a computer or reading. Your eyes progressively feel more dry/sandy/gritty as the day goes on. 1 Never Driving at night is difficult because of glare from highlights. Fluorescent lights bother you in large spaces (grocery store, department store, etc.). 1 Never 2 Rarely 2 Rarely 3 Sometimes 3 Sometimes 4 Very Often 4 Very Often 5 Always 5 Always Dizziness Riding in a car gives you motion sickness. You sometimes feel a sensation of vertigo or disconnectedness from your environment. 1 Never 2 Rarely 3 Sometimes 4 Very Often 5 Always? Additional Notes Any additional notes about these symptoms: FOR DOCTOR / STAFF USE ESO ESO BI DATE SYNC (DIST) EXO SYNC (NEAR) EXO SYNC (RX) BO R RGLI TM

64 Population Study Confirms Size & Severity of Problem Trigeminal Dysphoria Index FOR PATIENT USE Lifestyle Index PT INITIALS This survey is meant to help your doctor understand what you re experiencing on a regular basis whether it s caused by your eyes, posture, stress, etc. Your responses will help make sure you receive the best care possible. DATE FOR OFFICE USE 2017 Population study of eye exams How often do you experience any of these symptoms? Circle one: Headaches You get headaches of any severity each week (even just a dull ache counts). Your headaches tend to get worse later in the day. Your headaches are generally worse at work than they are at home or on weekends. 1 Never 2 Rarely 3 Sometimes 4 Very Often 5 Always Stiffness / pain in neck / shoulders Discomfort with Computer Use Tired Eyes Your neck gets stiff and sore when you work at a computer or read (This might even be from your posture). You experience frequent tension in your head, neck or shoulders. You get frequent massages/chiropractic adjustments. 1 Never You feel like you are more productive at work in the morning vs. the afternoon. Your eyes get tired, burn, or get red easily when you work at a computer for long hours. 1 Never 2 Rarely 3 Sometimes 4 Very Often Your eyes feel fatigued/tired at the end of a workday. Your eyes generally feel better in the morning compared to the end of the day. 1 Never 2 Rarely 2 Rarely 3 Sometimes 4 Very Often Number of hours per day using a digital device: 3 Sometimes 4 Very Often 5 Always 5 Always 5 Always Trigeminal Dysphoria Index Dry Eye Sensation Your eyes and/or contacts tend to dry out when you are working at a computer or reading. Your eyes progressively feel more dry/sandy/gritty as the day goes on. 1 Never 2 Rarely 3 Sometimes 4 Very Often 5 Always Light Sensitivity Driving at night is difficult because of glare from highlights. Fluorescent lights bother you in large spaces (grocery store, department store, etc.). 1 Never 2 Rarely 3 Sometimes 4 Very Often 5 Always Dizziness Riding in a car gives you motion sickness. You sometimes feel a sensation of vertigo or disconnectedness from your environment. 1 Never 2 Rarely 3 Sometimes 4 Very Often 5 Always? Additional Notes Any additional notes about these symptoms: FOR DOCTOR / STAFF USE ESO ESO BI DATE SYNC (DIST) EXO SYNC (NEAR) EXO SYNC (RX) BO R RGLI TM

65 Population Study Confirms Size & Severity of Problem Trigeminal Dysphoria Index FOR PATIENT USE Lifestyle Index PT INITIALS This survey is meant to help your doctor understand what you re experiencing on a regular basis whether it s caused by your eyes, posture, stress, etc. Your responses will help make sure you receive the best care possible. DATE FOR OFFICE USE 2017 Population study of eye exams How often do you experience any of these symptoms? Circle one: Headaches You get headaches of any severity each week (even just a dull ache counts). Your headaches tend to get worse later in the day. Your headaches are generally worse at work than they are at home or on weekends. 1 Never 2 Rarely 3 Sometimes 4 Very Often 5 Always Stiffness / pain in neck / shoulders Discomfort with Computer Use Tired Eyes Your neck gets stiff and sore when you work at a computer or read (This might even be from your posture). You experience frequent tension in your head, neck or shoulders. You get frequent massages/chiropractic adjustments. 1 Never You feel like you are more productive at work in the morning vs. the afternoon. Your eyes get tired, burn, or get red easily when you work at a computer for long hours. 1 Never 2 Rarely 3 Sometimes 4 Very Often Your eyes feel fatigued/tired at the end of a workday. Your eyes generally feel better in the morning compared to the end of the day. 1 Never 2 Rarely 2 Rarely 3 Sometimes 4 Very Often Number of hours per day using a digital device: 3 Sometimes 4 Very Often 5 Always 5 Always 5 Always Trigeminal Dysphoria Index Dry Eye Sensation Your eyes and/or contacts tend to dry out when you are working at a computer or reading. Your eyes progressively feel more dry/sandy/gritty as the day goes on. 1 Never 2 Rarely 3 Sometimes 4 Very Often 5 Always Light Sensitivity Driving at night is difficult because of glare from highlights. Fluorescent lights bother you in large spaces (grocery store, department store, etc.). 1 Never 2 Rarely 3 Sometimes 4 Very Often 5 Always Dizziness Riding in a car gives you motion sickness. You sometimes feel a sensation of vertigo or disconnectedness from your environment. 1 Never 2 Rarely 3 Sometimes 4 Very Often 5 Always? Additional Notes Any additional notes about these symptoms: FOR DOCTOR / STAFF USE ESO ESO BI DATE SYNC (DIST) EXO SYNC (NEAR) EXO SYNC (RX) BO R RGLI TM

Population Study Confirms Size & Severity of Problem Trigeminal Dysphoria Index FOR PATIENT USE Lifestyle Index PT INITIALS This survey is meant to help your doctor understand what you re

66 Population Study Confirms Size & Severity of Problem Trigeminal Dysphoria Index FOR PATIENT USE Lifestyle Index PT INITIALS This survey is meant to help your doctor understand what you re experiencing on a regular basis whether it s caused by your eyes, posture, stress, etc. Your responses will help make sure you receive the best care possible. DATE FOR OFFICE USE 2017 Population study of eye exams How often do you experience any of these symptoms? Circle one: Headaches You get headaches of any severity each week (even just a dull ache counts). Your headaches tend to get worse later in the day. Your headaches are generally worse at work than they are at home or on weekends. 1 Never 2 Rarely 3 Sometimes 4 Very Often 5 Always Stiffness / pain in neck / shoulders Discomfort with Computer Use Tired Eyes Your neck gets stiff and sore when you work at a computer or read (This might even be from your posture). You experience frequent tension in your head, neck or shoulders. You get frequent massages/chiropractic adjustments. 1 Never You feel like you are more productive at work in the morning vs. the afternoon. Your eyes get tired, burn, or get red easily when you work at a computer for long hours. 1 Never 2 Rarely 3 Sometimes 4 Very Often Your eyes feel fatigued/tired at the end of a workday. Your eyes generally feel better in the morning compared to the end of the day. 1 Never 2 Rarely 2 Rarely 3 Sometimes 4 Very Often Number of hours per day using a digital device: 3 Sometimes 4 Very Often 5 Always 5 Always 5 Always Trigeminal Dysphoria Index Dry Eye Sensation Your eyes and/or contacts tend to dry out when you are working at a computer or reading. Your eyes progressively feel more dry/sandy/gritty as the day goes on. 1 Never 2 Rarely 3 Sometimes 4 Very Often 5 Always Light Sensitivity Driving at night is difficult because of glare from highlights. Fluorescent lights bother you in large spaces (grocery store, department store, etc.). 1 Never 2 Rarely 3 Sometimes 4 Very Often 5 Always Dizziness Riding in a car gives you motion sickness. You sometimes feel a sensation of vertigo or disconnectedness from your environment. 1 Never 2 Rarely 3 Sometimes 4 Very Often 5 Always? Additional Notes Any additional notes about these symptoms: FOR DOCTOR / STAFF USE ESO ESO BI DATE SYNC (DIST) EXO SYNC (NEAR) EXO SYNC (RX) BO R RGLI TM

67 IOL Market: $6 Billion Glasses Market: $109 Billion

69 Thank You! Eyecare s Most Revolutionary Optical Solution

Headache Management Center

Headache Management Center DunesEye.com The Headache Management Center of Dunes Eye Consultants was launched in response to the widespread need for alternative treatments for those suffering from chronic