Arteries AWAY. Branch. Typically oxygenated.

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1 Arteries AWAY Branch Typically oxygenated.

2 Capillaries Smallest. Most abundant. 10 billion. Huge surface area. Exchange

3 Veins TOWARDS Converge. Typically deoxygenated.

4 3 Layers of the Vascular Wall Tunica interna (intima) Tunica media Tunica externa (adventitia).

5 Tunica Interna/Intima Lining. Endothelium. Simple squamous Continuous with endocardium Areolar CT. Only layer in capillaries.

6 Tunica Media Smooth muscle plus elastic fibers. Most prominent layer in arteries.

7 Tunica Externa/Adventitia Primarily collagen Anchors Most prominent layer in veins

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9 Elastic Arteries Aorta and major branches. Act as AUXILIARY PUMPS.

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11 Muscular Arteries Regional distribution Significant layer

12 Arterioles Smallest. May or may not have an externa. Highly innervated by vasomotor neurons. Easy to change the diameter. Regulation of blood pressure and flow.

13 Tunica Media Smooth muscle tone Regulated by: Metabolites Hormones Sympathetic vasomotor neurons.

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15 Increased NE release by a vasomotor neuron causes: Tunica media smooth muscle tone to: Vessel diameter to: Resistance to blood flow in the vessel to: Blood flow thru the vessel to:

16 Capillaries Smallest. Thin walls Billions Function? Almost everywhere.

17 Continuous capillaries Most common and least permeable. Abundant in No endothelial holes. Intercellular clefts.

18 Fenestrated capillaries Found in Intercellular clefts Endothelial holes

19 Sinusoids (Discontinuous Capillaries) Most permeable and least common. Big endothelial holes Intercellular clefts. Macrophages in their lining. Found in

20 How does aerobic training affect the density of capillaries in skeletal muscle tissue?

21 Arterial end True capillaries Venous end Endothelium Endothelium Smooth muscle cells Thoroughfare channel Arteriole Postcapillary venule Relaxed precapillary sphincters

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23 1. Precapillary sphincters in his rectus femoris would 2. Precapillary sphincters in his large intestine would

24 Thin walled w all 3 tunics. TE is the largest. Large lumens. Low Pressure & low resistance High compliance Smooth muscle prevents distention Blood reservoirs Veins

25 Blood Distribution Pulmonary circulation ~18% Lung Heart Systemic veins 55% Heart Systemic capillaries 5% Systemic arteries 10% ~12% Systemic circulation ~70%

26 Low venous pressure necessitates valves

27 Capillary Exchange Btwn blood plasma and tissue fluid. Nutrients, wastes, signaling molecules Diffusion! FLUID

28 Capillary Hydrostatic Pressure Capillary BP Pushes fluid from plasma to ISF

29 Capillary Osmotic Pressure Mostly due to albumin. Pulls fluid from ISF to plasma

30 Interstitial Hydrostatic Pressure Usually inconsequential b/c of low ISF volume It would push fluid from ISF to plasma

31 Interstitial Osmotic Pressure Usually inconsequential b/c of low ISF [protein] It would pull fluid from the plasma into the ISF

32 Net Filtration Pressure NFP = (CHP + IOP) - (COP + IHP) In effect: NFP = CHP - COP

33 Capillary Fluid Exchange CBP Pressure COP Arterial end Venous end Distance along the capillary

34 Capillary Fluid Exchange Capillary HP usually slightly exceeds capillary OP.

35 Factors Affecting Local Blood Flow Degree of vascularization Concentration of local regulatory factors Total blood flow

36 Degree of Vascularization Depends on metabolic activity

37 Angiogenesis vs. Regression

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39 Local Vasoactive Chemicals Tissue temp. Tissue CO2 levels EXERCISE Tissue O2 levels Arterioles serving tissue vaso Lactic acid levels blood flow to tissue CO2 Lactic acid Heat O2

40 Inflammation Damaged Tissues Activate WBCs Release inflammatory chemicals (e.g. histamine, bradykinin) Local vasodilation occurs Increased blood flow delivers WBCs, immune proteins, etc.

41 Blood Pressure Force per unit area exerted on the vessel wall by blood. Millimeters of mercury (mmhg). All vessels

42 Systolic Blood Pressure

43 Diastolic Blood Pressure

44 Systolic pressure MAP 60 Diastolic pressure 40 Arterial end of capillary 20 Venous end of capillary Pressure gradient = 93 mm Hg na c av a ins Ve s nu le Ve Ve Ca pil lar ies es iol ter Ar Ar ter ies 0 Ao rta Blood pressure (mm Hg) 120

45 What would happen to arterial BP if the amount of blood pumped into the arteries increased? What would happen to arterial BP if the resistance in the arterioles went up? What would happen to arterial BP if there was more blood in the entire system?

46 Phentolamine is a chemical that prevents norepinephrine from binding to (and affecting) the smooth muscle cells in blood vessels. What would phentolamine do to: - arteriole muscle tone - arteriole radius - arteriole diameter - arteriole resistance - blood pressure Why might someone taking phentolamine experience some reflexive tachycardia?

47 Pulse What creates it? How/Where do you measure it? What s its relationship to heart rate?

48 Pulse Pressure Δ in arterial pressure caused by ventricular systole. Varies directly with PP = SBP DBP.

49 Mean Arterial Pressure (MAP) Arterial BP fluctuates. Why? MAP is the pressure driving blood flow. MAP is a weighted average of SBP and DBP.

50 Mean Arterial Pressure (MAP) MAP = ⅔DBP + ⅓SBP MAP = DBP + ⅓PP

51 Capillary Blood Pressure Low BP. Good for exchange. Declines from 40 mmhg to 20 mmhg.

52 Venous Blood Pressure Even lower BP. Very small gradient.

53 What is responsible for venous return? Remaining force imparted by ventricular systole. Gravity. Skeletal muscle pump. Respiratory pump. Venoconstriction.

54 Remaining Systolic Force

55 Gravity

56 Skeletal Muscle Pump To heart Increased pressure opens valve Contracted skeletal muscles Valve closed (to prevent blood backflow) Vein Blood flow from tissues

57 Respiratory Pump Thoracic cavity Abdominopelvic cavity Inspiration Increases blood flow into thoracic veins Expiration Increases blood flow into heart and abdominal veins Decreased intrathoracic pressure Increased intrathoracic pressure Diaphragm contracts Diaphragm relaxes Blood moves superiorly Compression Increased intra-abdominal pressure Decreased intra-abdominal pressure Release of compression

58 Venoconstriction An increase in sympathetic activity causes: NE release on the TM of medium/large veins to Venous pressure to Venous return to

59 Relationship Btwn Venous Return and Cardiac Output

60 Resistance Opposition to flow Measure of friction. Peripheral resistance. Direction!

61 Sources of Resistance Blood viscosity. Total vessel length. Vessel radius.

62 Viscosity Resistance

63 What is the major contributor to blood viscosity? Does viscosity change in a healthy person? An increase in plasma EPO will cause resistance to

64 Total Vessel Length Resistance

65 Vessel Radius (1/radius4) resistance

66 Does vessel radius change in a normal healthy person? Which vessels? How is the change achieved?

67 Which tube has the greater intrinsic resistance? A B What layer of the vessel wall has the greatest effect on vessel resistance? a. Interna b. Media c. Externa

68 Resistance (length)(viscosity) (radius)4

69 Which tube has the LEAST resistance? Which tube has the GREATEST resistance?

70 FLOW PRESSURE GRADIENT RESISTANCE Cardiac output Vasodilation An increase in cardiac output causes a steeper pressure gradient mm Hg Increased pressure gradient Distance from heart Blood flow Less resistance, which is caused by vasodilation, reduction in vessel length,or decrease in blood viscosity

71 FLOW PRESSURE GRADIENT RESISTANCE Vasoconstriction Cardiac output mm Hg A decrease in cardiac output causes a smaller pressure gradient Decreased pressure gradient Distance from heart Blood flow Greater resistance, which is caused by vasoconstriction, increase in vessel length, or increase in blood viscosity

72 Brain Centers for Short Term BPControl Vasomotor Cardioinhibitory Cardioacceleratory

73 Increased vasomotor center activity creased sympathetic output to arterioles Vaso creased peripheral resistance creased blood pressure

74 Increased cardioacceleratory center activity creased sympathetic output to heart creased heart rate and stroke volume creased cardiac output creased blood pressure

75 Increased cardioinhibitory center activity creased parasympathetic output to heart creased heart rate creased cardiac output creased blood pressure

76 Baroreceptor Reflex

77 Baroreceptor Reflex Baroreceptors signals the cardiac and vasomotor centers via CN IX and X. Frequency of these impulses is proportional to MAP. Cardiac and vasomotor centers adjust their output accordingly.

78 A Fun Way to Demonstrate the Baroreceptor Reflex Take the subject s radial pulse. Find the carotid pulse point and GENTLY press on it. What will happen to the radial pulse? Why?

79 Adrenal Medullary Mechanism Release epinephrine (and a small amt of NE) in response to: Large drops in MAP. Increases in physical activity. Stressful situations.

80 Adrenal Medullary Mechanism How would activation of the adrenal medulla affect: HR SV CO TPR BP

81 Renin-Angiotensin-Aldosterone System Renin Angiotensin II

82 Indirect Mechanism System Renin-Angiotensin-Aldosterone Angiotensin II Vasoconstriction Aldosterone & Antidiuretic hormone Thirstiness Increased TPR Increased BV Increased BP

83 A 25yo woman complains to her doctor of headaches and blurred vision. Her blood pressure is 200/130 mmhg. After the BP has been reduced, investigations are made to find the cause of the problem. It s discovered that her left renal artery is narrowed. Why would this cause the rise in BP?

84 Atrial Natriuretic Peptide Increased atrial stretch Atrial cells release ANP ANP is a vasodilator ANP increases urine sodium and thus urine output TPR blood volume BP

85 na Ve Ca va ca Blood velocity Cross-sectional area Velocity of blood flow (cm/second) ins Ve e pil s lar ies Ve nu les iol ter 1000 Ar 4000 El art astic eri es M art uscu eri lar es Total cross-sectional area (cm2) Cross-Sectional Area vs. Velocity

86 Blood Distribution During Exercise