Takotsubo Cardiomyopathy Complicating Sick Sinus Syndrome

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1 Takotsubo Cardiomyopathy Complicating Sick Sinus Syndrome Jun Kim MD Department of Internal Medicine, Pusan National University Yangsan Hospital, Yangsan, Korea Takotsubo cardiomyopathy complicating sick sinus syndrome ABSTRACT Takotsubo cardiomyopathy presents with diverse electrocardiographic changes, possibly masquerading as an acute coronary syndrome, and may occur after psychological, medical, or surgical stress. We describe a case of a 69-year-old woman with sick sinus syndrome, repolarization abnormalities, akinesia of the left ventricular apex, and normal coronary arteries. The patient s electrocardiographic and echocardiographic abnormalities normalized after the implantation of a permanent pacemaker; cardiac events did not recur within a 5-year follow-up period. Key words: pacemaker sick sinus syndrome takotsubo cardiomyopathy Received: January 20, 2013 Accepted: June 30, 2013 Correspondence: Jun Kim, MD, Department of Internal Medicine, Pusan National University Yangsan Hospital, Geum-o Street 20, Yangsan , Republic of Korea Tel: , Fax: mdjunkim@gmail.com 24 The Official Journal of Korean Heart Rhythm Society

2 ECG & EP CASES VOL.14 NO.2 25

3 A B C Figure 1. Surface electrocardiograms of the patient: (A) electrocardiogram at initial presentation, (B) after implantation of the pacemaker, and (C) 5 months after the implantation of a pacemaker. 26 The Official Journal of Korean Heart Rhythm Society

4 A C E B D F Figure 2. Apical 4-chamber views of the left ventricle. End-systolic and end-diastolic images at initial presentation (A, B), 2 days after pacemaker implantation (C, D), and 2 months after pacemaker implantation (E, F). A B Figure 3. Left ventriculogram of the patient: (A) end-systolic frame and (B) end-diastolic frame. VOL.14 NO.2 27

5 References 1. Tsuchihashi K, Ueshima K, Uchida T, Oh-mura N, Kimura K, Owa M, Yoshiyama M, Miyazaki S, Haze K, Ogawa H, Honda T, Hase M, Kai R, Morii I; Angina Pectoris-Myocardial Infarction Investigations in Japan. Transient left ventricular apical ballooning without coronary artery stenosis: a novel heart syndrome mimicking acute myocardial infarction. J Am CollCardiol. 2001;38: Mawad W, Guerra PG, Dubuc M, Khairy P. Tako-tsubo cardiomyopathy following transcatheter radiofrequency ablation of the atrioventricular node. Europace. 2007;9: Hasdemir C, Yavuzgil O, Simsek E, Ulucan C, Cinar CS. Stress cardiomyopathy (Tako-Tsubo) following radiofrequency ablation in the right ventricular outflow tract. Europace. 2008;10: Chun GS, Kwok V, Pang DK, Lau TK. Transient left ventricular apical ballooning syndrome (takotsubo cardiomyopathy) as a complication of permanent pacemaker implantation. Int J Cardiol. 2007;117:e27-e Kohnen RF, Baur LH. A Dutch case of a takotsubo cardiomyopathy after pacemaker implantation. Neth Heart J. 2009;17: Rotondi F, Manganelli F, Di Lorenzo E, Marino L, Candelmo F, Alfano F, Stanco G, Rosato G. Tako-tsubo cardiomyopathy in a patient with pacemaker syndrome. Europace. 2009;11: Golzio PG, Anselmino M, Presutti D, Cerrato E, Bollati M, Gaita F. Takotsubo cardiomyopathy as a complication of pacemaker implantation. J Cardiovasc Med. (Hagerstown) 2011;12: Madias C, Fitzgibbons TP, Alsheikh-Ali AA, Bouchard JL, Kalsmith B, Garlitski AC, Tighe DA, Estes NA 3rd, Aurigemma GP, Link MS. Acquired long QT syndrome from stress cardiomyopathy is associated with ventricular arrhythmias and torsades de pointes. Heart Rhythm. 2011;8: Kurisu S, Inoue I, Kawagoe T, Ishihara M, Shimatani Y, Nakama Y, Ohkawa K, Maruhashi T, Kagawa E, Dai K, Aokage T. Torsade de pointes associated with bradycardia and takotsubo cardiomyopathy. Can J Cardiol. 2008;24: Inoue M, Kanaya H, Matsubara T, Uno Y, Yasuda T, Miwa K. Complete atrioventricular block associated with takotsubo cardiomyopathy. Circ J. 2009;73: Wittstein IS, Thiemann DR, Lima JA, Baughman KL, Schulman SP, Gerstenblith G, Wu KC, Rade JJ, Bivalacqua TJ, Champion HC. Neurohumoral features of myocardial stunning due to sudden emotional stress. N Engl J Med. 2005;352: Lin C, Cvetanovic I, Ke X, Ranade V, Somberg J. A mechanism for the potential proarrhythmic effect of acidosis, bradycardia, and hypokalemia on the blockade of human ether-a-go-gorelated gene (HERG) channels. Am J Ther. 2005;12: Kawai S, Kitabatake A, Tomoike H; Takotsubo Cardiomyopathy Group.Guidelines for diagnosis of takotsubo (ampulla) cardiomyopathy. Circ J. 2007;71: Sharkey SW, Windenburg DC, Lesser JR, Maron MS, Hauser RG, Lesser JN, Haas TS, Hodges JS, Maron BJ. Natural history and expansive clinical profile of stress (tako-tsubo) cardiomyopathy. J Am Coll Cardiol. 2010;55: Agarwal V, Kant G, Hans N, Messerli FH. Takotsubo-like cardiomyopathy in pheochromocytoma. Int J Cardiol. 2011;153: The Official Journal of Korean Heart Rhythm Society

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