Impact of in-hospital delay to invasive treatment of NSTEMI patients on early and 12-month clinical outcomes
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1 Impact of in-hospital delay to invasive treatment of NSTEMI patients on early and 12-month clinical outcomes Analysis from the PL-ACS Registry
2 Marek Gierlotka 1, Grzegorz Opolski 2, Lech Poloński 1, Marcin Dąda 2, Krzysztof Wilczek 1, Mariusz Gąsior 1, Krzysztof J Filipiak rd Department of Cardiology, Silesian Center for Heart Diseases, Medical University of Silesia, Zabrze, Poland 2 1 st Department of Cardiology, Medical University of Warsaw, Poland
3 Background
4 Aim Although previous clinical trials have shown that invasive strategy improves clinical outcomes in patients with non-st-segment elevation myocardial infarction (NSTEMI), the timing of such procedure remains ambiguous The purpose of this analysis was: To assess the impact of in-hospital delay to invasive treatment on early and 12-month clinical outcomes in NSTEMI patients
5 Methods - PL-ACS Registry in brief (1) In brief, the PL-ACS registry is an ongoing, nationwide, multicentre, prospective, observational study of consecutively hospitalized patients with the whole spectrum of acute coronary syndromes in Poland. It is a joint initiative of the Silesian Centre for Heart Diseases and the Ministry of Health of Poland. Logistic support is obtained from the National Health Fund, which is a nationwide public health insurance institution in Poland and from which an insurance policy is required for all Polish citizens. The pilot phase of the Registry commenced in October 2003 in the Silesia region. In the following months, further regions were opened and, since June 2005, all Polish regions collect data for the PL-ACS Registry. A detailed protocol with inclusion and exclusion criteria, methods and logistics, and definitions of all fields in the registry dataset was prepared before the registry was started. However, it has since been revised in May 2004 be compatible with the Cardiology Audit and Registration Data Standards (CARDS). Nevertheless, the PL-ACS Registry case report form (CRF) covers only part of the CARDS dataset.
6 Methods - PL-ACS Registry in brief (2) HOSPITALS Hospitals are invited to enter the registry either if they have one of the following wards: coronary care unit, cardiology, cardiac surgery, internal medicine or intensive care unit, or if they hospitalize at least 10 acute coronary syndrome patients per year. PATIENTS All admitted patients with suspected ACS are screened for eligibility to enter the registry, but they were not enrolled until acute coronary syndrome is confirmed. The patients are then classified as having unstable angina, non-st-segment myocardial infarction, or ST-segment elevation myocardial infarction. If the patient is hospitalized during the same acute coronary syndrome in more than one hospital (transferred patient), all hospitals are required to complete the registry data. These hospitalizations are linked together during data management and are analyzed as one ACS.
7 Cumulative number of patients Methods - PL-ACS Registry in brief (3) DATA COLLECTION Data are collected by skilled physicians who were in charge of each particular patient and either entered directly into an electronic CRF or temporarily printed onto a CRF before being transferred to an electronic CRF. Internal checks for missing or conflicting data and values markedly out of the expected range are implemented by the software. In the data management and analysis centre, further edit checks are applied if necessary. FOLLOW-UP DATA All-cause mortality data with exact dates of deaths are obtained from official mortality records from the National Health Fund Number of patients Number of centers 512 Invasive 88 Non-invasive Year
8 Methods We assessed baseline characteristics, and clinical outcomes in NSTEMI pts, without cardiogenic shock or pulmonary edema on admission hospitalized between October 2003 and October 2008 Patients who underwent intervention within the first 2 hours were excluded Four groups were analyzed based on the time from admission to coronary angiography: 2-24h, 24-48h, 48-72h, and >72h, respectively The primary outcomes were: in-hospital MACE (death, MI, stroke or major bleeding), 30-day mortality and 12-month mortality
9 Patients NSTEMI N = Exclusion -> Non-invasive treatment N = NSTEMI, invasive treatment N = Exclusions -> Killip 3 or 4 on admission N = NSTEMI, invasive treatment, Killip 1 or 2 N = h N=10199 (42%) 2-24 h N=6994 (29%) h N=1729 (7%) h N=811 (3%) > 72 h N=1899 (8%) N/A N=2639 (11%)
10 Results (1) Baseline characteristics
11 Results (2) Treatment
12 Results (3) In-hospital outcomes
13 Results (4) Follow-up mortality
14 Results (5) 12-month mortality
15 Conclusion Early invasive strategy within 2-48h from hospital presentation in NSTEMI patients is safe and associated with shorter length of stay when compared to catheter-based interventions performed later The delayed intervention after 72h increases 12-month mortality
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