AN EARLY WARNING SYSTEM FOR CARDIOVASCULAR DISEASE

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Hector Morgan
5 years ago
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1 AN EARLY WARNING SYSTEM FOR CARDIOVASCULAR DISEASE

Good for your patients. Good for your practice. Using the AngioDefender system to complement your patients care routine enables you to: Improve your patient management decisions.

2 Good for your patients. Good for your practice. Using the AngioDefender system to complement your patients care routine enables you to: Improve your patient management decisions. Identify early-stage CVD in asymptomatic patients and monitor the effectiveness of prescription therapy and lifestyle modification. Provide quick, accurate assessments. Non-invasive and easy to use, the AngioDefender test takes under 20 minutes and delivers accurate, reproducible results. Encourage repeat visits. Measure your patients progress and engage in ongoing, productive conversations about heart health. Offer a test that other practitioners do not. Attract new, health-conscious patients by being among the first to offer AngioDefender testing.

PREDICT CARDIOVASCULAR DISEASE BEFORE SYMPTOMS APPEAR

dysfunction is a key biomarker of atherosclerosis and

In fact, a patient s level of endothelial dysfunction can

a patient does not currently exhibit symptoms.

the blood vessels, resulting in a measurable reduction of

PREDICT & PROTECT EARLY-STAGE MID-STAGE LATE-STAGE

Result in: Lower %FMD Plaque formation Calcium build-up

form Eventual blockage Result in: Chest pain Heart attack

ENDOTHELIUM CVD is a leading DAMAGED cause of death, it s

The AngioDefender system enables you to assess a patient

3 PREDICT CARDIOVASCULAR DISEASE BEFORE SYMPTOMS APPEAR Clinical studies have demonstrated that endothelial cell dysfunction is a key biomarker of atherosclerosis and cardiovascular disease (CVD). In fact, a patient s level of endothelial dysfunction can predict the occurrence of CVD years in advance, even when a patient does not currently exhibit symptoms. This is because endothelial damage leads to thickening of the blood vessels, resulting in a measurable reduction of arterial compliance during the early stages of CVD. PREDICT & PROTECT EARLY-STAGE MID-STAGE LATE-STAGE INCREASING VASCULAR AGE Cardiovascular risk factors Result in: Lower %FMD Plaque formation Calcium build-up Result in: Vessel stiffening i and narrowing Blood clots form Eventual blockage Result in: Chest pain Heart attack Stroke HEALTHY ENDOTHELIUM DYSFUNCTIONAL Though ENDOTHELIUM CVD is a leading DAMAGED cause of death, it s largely ENDOTHELIUM preventable. The AngioDefender system enables you to assess a patient s level of endothelial dysfunction early on, allowing time for behavioral and pharmacologic intervention to protect the endothelium from further damage.

MEASURING ENDOTHELIAL DYSFUNCTION BY ANGIODEFENDER The endothelium is the single-cell-thick interior lining of

Dilation of blood vessels is enabled by endothelial cells, which release vasodilators like nitric oxide (NO)

FLOW MEDIATED DILATION OF THE BRACHIAL ARTERY % FMD IS MEASURE OF DILATION POST OCCLUSION.

The percentage of difference in diameter between fully dilated and resting blood vessels is known as

Healthier vessels release more NO, leading to a higher %FMD and a lower risk of CVD and atherosclerosis.

HOW THE ANGIODEFENDER SYSTEM WORKS To measure %FMD, the device runs through a series of inflations and

4 MEASURING ENDOTHELIAL DYSFUNCTION BY ANGIODEFENDER The endothelium is the single-cell-thick interior lining of all blood vessels in the body. Dilation of blood vessels is enabled by endothelial cells, which release vasodilators like nitric oxide (NO) in response to increased blood flow. FLOW MEDIATED DILATION OF THE BRACHIAL ARTERY % FMD IS MEASURE OF DILATION POST OCCLUSION... Increased blood flow rate Increased shear stress Endothelium releases nitric oxide Smooth muscle relaxes The percentage of difference in diameter between fully dilated and resting blood vessels is known as flowmediated dilation (%FMD). Healthier vessels release more NO, leading to a higher %FMD and a lower risk of CVD and atherosclerosis. AngioDefender measures these sensitive changes, then calculates and converts them into a %FMD score. HOW THE ANGIODEFENDER SYSTEM WORKS To measure %FMD, the device runs through a series of inflations and deflations to analyze the endothelium s response to increased blood flow. Then, by combining the principles of blood pressure, pulse wave analysis, and a proprietary data analysis algorithm, the AngioDefender system produces a unique %FMD score in just minutes. The AngioDefender system accurately and reproducibly quantifies %FMD without the need for expensive ultrasound equipment or operator expertise.

5 EARLIER DETECTION, HEALTHIER OUTCOMES How would your practice change if you could predict CVD in patients before symptoms appear? Before an EKG or angiogram is administered? Even before lab tests are performed? Use AngioDefender to: + Evaluate CVD risk + Monitor treatments + Assess interventions The following behavioral and pharmacological interventions have been clinically shown to reduce several CVD risk factors and positively affect endothelial function. CVD RISK FACTOR High BMI Diabetes Tobacco smoking High cholesterol Hypertension Sleep Apnea INTERVENTION/TREATMENT Exercise, diet modification Glycemic control Smoking cessation Exercise, diet modification Lipid-lowering therapy (i.e., statins) Exercise, diet modification Antihypertensives (i.e., ACE inhibitors) CPAP device EFFECT OF INTERVENTION ON ENDOTHELIAL FUNCTION Visit EveristHealth.com to learn more about incorporating the AngioDefender system into your practice. The AngioDefender system is not commercially available in the United States. REF:110005

6 The AngioDefender system is the most effective solution to the technical, clinical, usability, and cost challenges associated with detecting early endothelial dysfunction. Visit EveristHealth.com to learn more about incorporating the AngioDefender system into your practice W. Ellsworth Road Ann Arbor, MI USA info@everisthealth.com

AngioDefender. A man is as old as his arteries. Dr. Thomas Sydenham, British physician ( ) known as the English Hippocrates

AngioDefender. A man is as old as his arteries. Dr. Thomas Sydenham, British physician ( ) known as the English Hippocrates AngioDefender A man is as old as his arteries Dr. Thomas Sydenham, British physician (1624-1689) known as the English Hippocrates Since the dawn of modern clinical medicine, when patient observation and