TAVI limitations for low risk patients
|
|
- Ruby Webb
- 5 years ago
- Views:
Transcription
1 TAVI limitations for low risk patients Dr. T. Modine / P. Lancellotti MD, PhD, MBA CHRU de Lille, France
2 Potential conflicts of interest Speaker's name: Thomas Modine I have the following potential conflicts of interest to report: Affiliation/Financial Relationship Grant/Research Support Consulting Fees / Honoraria Major Stock Shareholder/Equity Royalty Income Ownership/Founder Intellectual Property Rights Other Financial Benefit Company Edwards Abbott, Boston Scientific, Medtronic, Edwards, Cephea, Microport, GE Valmy Microport Valmy ltd Yes Nil
3 TAVI in the last years Huge improvements, but
4 TAVI vs. SAVR where does the evidence come from? Observational studies propensity score matching Randomized controlled trials
5 STS database n=141, % Intermediate risk (STS 4-8%) 79.9% Low risk (STS <4%) *Thourani, et al., Ann Thorac Surg 2015; 99: 55-61
6 Similar outcomes between TAVI & SAVR in matched intermediate risk... STS (%, mean) Log EuroSCORE (%, mean) TAVI (n=255 ) Piazza 1 OBSERVANT 2 Latib 3 SAVR (n=255) p TAVI (n=133) SAVR (n=133) p TAVI (n=111) SAVR (n=111) na na Day Mortality (%) Piazza, et al. J Am Coll Cardiol Intv 2013; 6: D Errigo, et al. Int J Cardiol 2013; 167: Latib, et al. Am Heart J 2012; 164:910-7 p
7 2-Year All-Cause Mortality CoreValve ADVANCE Registry 36% 26% 4% 14% 7% 21% CoreValve ADVANCE Study
8 Mortality and Stroke: S3i At 30 Days (As Treated Patients) 100 Mortality 100 Stroke All-Cause Cardiovascular All Stroke Disabling O:E = 0.21 (STS 5.3%) % % S3i S3i
9 TAVI in the last years Huge improvements, but Matter of debate Complications rate reduction
10 % All-Cause Mortality at 30 Days 30-day All-cause Mortality 10% 8,4% 8% 7,0% 6% 5,1% 4,4% 4% 2% 3,5% 3,3% 2,9% 2,2% 1,3% 1,1% 0% CoreValve Extreme Risk N=489 SAPIEN TVT HR N=12182 SAPIEN PARTNER IIB N=276 LOTUS REPRISE II + Ext N=249 SAPIEN XT PARTNER IIB N=284 CoreValve High Risk N=390 Portico CE Study N=103 SAPIEN 3 PARTNER II S3 HR N=583 Direct Flow DISCOVER N=75 SAPIEN 3 PARTNER II S3i N=1076 0,0% Evolut R CE Study N=60 1 Popma, et al., J Am Coll Cardiol 2014; 63: ; 2 Holmes, et al., JAMA 2015; 313: ; 3 Leon, et. al. presented at ACC 2013; 4 Meredith, et al., presented at PCR London Valves 2014; 5 Adams, et al., N Engl J Med 2014; 370: ; 6 Manoharan, et al., et. al. presented at TCT 2014; 7 Kodali, et al., presented at ACC 2015; 8 Schofer, et al., J Am Coll Cardiol 2014; 63: 763-8; 9 Meredith, et al., presented at ACC 2015
11 % Patients with Moderate / Severe PVL at 30 Days Moderate to severe PVL 30% 25% 24,2% 20% 16,9% 15% 10% 11,4% 9,0% 5% 0% SAPIEN XT PARTNER IIB N=236 SAPIEN PARTNER IIB N=225 CoreValve Extreme Risk N=418 CoreValve High Risk N=356 4,0% 3,8% 3,4% Portico CE Study N=75 SAPIEN 3 PARTNER II S3 N=1504 Evolut R CE Study N=60 1,4% Direct Flow DISCOVER N=74 0,6% LOTUS REPRISE II + Ext N=177 1 Leon, et. al. presented at ACC 2013; 2 Popma, et al., J Am Coll Cardiol 2014; 63: ; 3 Adams, et al., N Engl J Med 2014; 370: ; 4 Manoharan, et al., et. al. presented at TCT 2014; 5 Kodali, et al., presented at ACC 2015; 6 Meredith, et al., presented at ACC 2015; 7 Schofer, et al., J Am Coll Cardiol 2014; 63: 763-8; 8 Meredith, et al., presented at PCR London Valves 2014
12 % Patients with PPM at 30 Days 35% 30-day Permanent Pacemaker 30% 28,9% 25% 20% 21,6% 19,8% 17,0% 15% 10% 13,0% 11,7% 10,1% 9,7% 6,4% 5,9% 5% 0% LOTUS REPRISE II + Ext N=249 CoreValve Extreme Risk N=489 CoreValve High Risk N=390 Direct Flow DISCOVER N=100 SAPIEN 3 PARTNER II S3 HR N=583 Evolut R CE Study N=60 SAPIEN 3 PARTNER II S3i N=1076 Portico CE Study N=103 SAPIEN XT PARTNER IIB N=284 SAPIEN PARTNER IIB N=276 1 Meredith, et al., presented at PCR London Valves 2014; 2 Popma, et al., J Am Coll Cardiol 2014; 63: ; 3 Adams, et al., N Engl J Med 2014; 370: ; 4 Schofer, et al., J Am Coll Cardiol 2014; 63: 763-8; 5 Kodali, et al., presented at ACC 2015; 6 Meredith, et al., presented at ACC 2015; 7 Manoharan, et al., et. al. presented at TCT 2014; 8 Leon, et. al. presented at ACC 2013
13 % Patients with Stroke at 30 Days 30-day stroke rate 8% 7% 6,8% 6% 5% 4% 4,9% 4,3% 4,1% 4,0% 4,0% 3,9% 3% 2,6% 2,5% 2% 1,5% 1% 0% LOTUS REPRISE II + Ext N=249 CoreValve High Risk N=390 SAPIEN XT PARTNER IIB N=284 SAPIEN PARTNER IIB N=276 Direct Flow DISCOVER N=75 CoreValve Extreme Risk N=489 Portico CE Study N=103 SAPIEN 3 PARTNER II S3i N=1076 SAPIEN TVT HR N=12182 SAPIEN 3 PARTNER II S3 HR N=583 0,0% Evolut R CE Study N=60 1 Meredith, et al., presented at PCR London Valves 2014; 2 Adams, et al., N Engl J Med 2014; 370: ; 3 Leon, et. al. presented at ACC 2013; 4 Schofer, et al., J Am Coll Cardiol 2014; 63: 763-8; 5 Popma, et al., J Am Coll Cardiol 2014; 63: ; 6 Manoharan, et al., et. al. presented at TCT 2014; 7 Kodali, et al., presented at ACC 2015; 8 Holmes, et al., JAMA 2015; 313: Meredith, et al., presented at ACC 2015
14 Durability Just be patient to see how old it will GROW
15 The NOTION Trial all-cause mortality 31.1% 29.4% Number at risk: Courtesy L. sondergaard
16 The NOTION Trial conclusions Through 5 years follow-up of the NOTION trial: Excellent haemodynamic valve performance was maintained Bioprosthetic failure was low and similar for the selfexpanding transcatheter (CoreValve) and the surgical valves implanted Structural valve deterioration was significantly greater for SAVR compared with TAVI There was no valve thrombosis and similar rates of endocarditis for both groups Courtesy L. sondergaard
17 Medtronic TAVR in Low Risk Patients Trial Design Patient Population: Low Risk Cohort Determined by Heart Team to be low surgical risk Primary Endpoint: Safety: Death, all stroke, life-threatening bleeding, major vascular complications, or AKI at 30 days Efficacy: Death or major stroke at 2 years (One year analysis for early FDA submission) Sample Size: ~1200 Subjects Follow-up Evaluations: 30-days, 6-month, 18-month, and 1 Through 5 years Number of Sites: Up to 80
18 PARTNER 3 Low Risk Study Design & Registries Severe Calcific Aortic Stenosis PARTNER 3 Registries Aortic ViV (n = 100) Alternative Access Registry (TA/TAo/Subclavian) (n = 100) Low Risk ASSESSMENT by Heart Team AND STS < 4 1:1 Randomization (n = 1,228) Mitral ViR (n = 50) Mitral ViV (n= 50) TF - TAVR (SAPIEN 3) CT Imaging sub-study (n = 200) Actigraphy/QoL sub-study SAVR (Any approved Surgical Bioprosthetic Valve) CT Imaging sub-study (n = 200) Actigraphy/QoL sub-study PRIMARY ENDPOINT: Composite of all-cause mortality, all stroke, or re-hospitalization at 1 year post procedure Follow-up: Annually through 10 years
19 TAVR in Low-Risk Patients TAVR is now the preferred therapy in AS patients : Inoperable High-risk Some intermediate-risk Secondary benefits associated with TAVR Reduced ICU and hospital LOS, More rapid QOL recovery, Lower frequency of AKI, bleeding, and post-operative AF Improved valve hemodynamics. TAVR is now being studied in low-risk AS patients in randomized clinical trials!
20 Conclusions A systematic fall in surgical risk scores is evident (Europe > US) Lower risk patients are currently being treated (Europe > US) Clinical outcomes in patients with lower surgical risk scores are excellent Risk scores need to be reconsidered: AGE as a decision factor? RCT: Partner III, EvolutR low risk, NOTION II
Le TAVI pour tout le monde?
Le TAVI pour tout le monde? Thierry Lefèvre Institut Cardiovasculaire Paris Sud, Massy Disclosure Statement of Financial Interest I currently have, or have had over the last two years, an affiliation or
More informationIgor Palacios, MD Director of Interventional Cardiology Massachusetts General Hospital Professor of Medicine Harvard Medical School
Aortic Stenosis: Current State of Percutaneous Therapies, Emerging Technologies and Future Directions Igor Palacios, MD Director of Interventional Cardiology Massachusetts General Hospital Professor of
More informationIs TAVI ready for prime time in: - Intermediate risk patients? - Low risk patients?
Is TAVI ready for prime time in: - Intermediate risk patients? - Low risk patients? Didier TCHETCHE, MD. Clinique PASTEUR, Toulouse, France, Conflicts of interest: -Consultant for Edwards LifeSciences
More informationTAVR: Review of the Robust Data from Randomized Trials
TAVR: Review of the Robust Data from Randomized Trials Nicholas J. Ruggiero II, MD,FACP, FACC, FSCAI, FSVM, FCPP Director, Structural Heart Disease and Non-Coronary Interventions Director, Jefferson Heart
More informationSevere Aortic Valve Disease: TAVR in Four Ages and Four Etiologies Age 25 y/o Congenital, 50 y/o Bicuspid, 75 y/o Rheumatic, 100 y/o Degenerative
Severe Aortic Valve Disease: TAVR in Four Ages and Four Etiologies Age 25 y/o Congenital, 50 y/o Bicuspid, 75 y/o Rheumatic, 100 y/o Degenerative Samin K. Sharma, MD, FACC, FSCAI Director Clinical & Interventional
More informationThe Sentinel Dual Filter Device Design Features & EU Clinical Trial Results
The Sentinel Dual Filter Device Design Features & EU Clinical Trial Results Nicolas M. Van Mieghem, MD, PhD, FESC Director of Interventional Cardiology Thoraxcenter, Erasmus MC Rotterdam Disclosure Statement
More informationThe Future of Medicine. Who to TAVR? Azeem Latib MD EMO-GVM Centro Cuore Columbus and San Raffaele Scientific Institute, Milan, Italy
The Future of Medicine Who to TAVR? Azeem Latib MD EMO-GVM Centro Cuore Columbus and San Raffaele Scientific Institute, Milan, Italy FIRST PATIENT TO UNDERGO PTCA FIRST PATIENT TO UNDERGO TAVI Grüntzig
More informationTrans Catheter Aortic Valve Replacement
Trans Catheter Aortic Valve Replacement Satish K Surabhi, MD,FACC,FSCAI Medical Director, Cardiac Cath Labs AnMed Health Heart and Vascular Care No financial conflict of interest related to this talk Will
More informationThe Role of TAVI in high-risk and normal-risk Patients
The Role of TAVI in high-risk and normal-risk Patients Joachim Schofer Hamburg University Cardiovascular Center and Department for percutaneous treatment of structural heart disease Albertinen Heart Center
More informationTAVR-Update Andrzej Boguszewski MD, FACC, FSCAI Vice Chairman, Cardiology Mid-Michigan Health Associate Professor Michigan State University, Central
TAVR-Update Andrzej Boguszewski MD, FACC, FSCAI Vice Chairman, Cardiology Mid-Michigan Health Associate Professor Michigan State University, Central Michigan University 1 Disclosure Chiesi Pharma- Consultant
More informationComplicanze durante TAVI. Brambilla Nedy IRCCS Policlinico San Donato
Complicanze durante TAVI Brambilla Nedy IRCCS Policlinico San Donato 0 2 4 6 9 11 14 16 22 26 31 33 37 43 52 61 69 78 87 93 106 113 121 151 171 186 201 225 267 283 294 311 349 502 515 709 1007 Number of
More informationTAVR: Intermediate Risk Patients
TAVR: Intermediate Risk Patients Oscar A. Mendiz.MD.FACC.FSCAI Director Cardiology & Cardiovascular Institute (ICyCC) Chief Interventional Cardiology Department Board of Directors Hospital & Favaloro University
More informationTranscatheter Aortic Valve Replacement
Transcatheter Aortic Valve Replacement Jesse Jorgensen, MD Medical Director, Cardiac Catheterization Laboratory Greenville Health System Greenville, South Carolina, USA January 30, 2016 Aortic Stenosis
More informationDebate: SAVR for Low-Risk Patients in 2017 is Obsolete AVR vs TAVI
Debate: SAVR for Low-Risk Patients in 2017 is Obsolete AVR vs TAVI Joseph E. Bavaria, MD Roberts-Measey Professor of Surgery Vice Chair, Division of Cardiovascular Surgery University of Pennsylvania Immediate
More informationIs TAVR Now Indicated in Even Low Risk Aortic Valve Disease Patients
Is TAVR Now Indicated in Even Low Risk Aortic Valve Disease Patients Saibal Kar, MD, FACC, FAHA, FSCAI Director of Interventional Cardiac Research Cedars Sinai Heart Institute, Los Angeles, CA Potential
More informationVinod H. Thourani, MD, FACC, FACS
Considering SAVR in the TAVR era: Surgical Implications of TAVR Vinod H. Thourani, MD, FACC, FACS Professor of Cardiothoracic Surgery and Medicine Chief of Cardiothoracic Surgery, Emory Hospital Midtown
More informationTAVR today: High Risk, Intermediate Risk Population, and Valve in Valve Therapy
TAVR today: High Risk, Intermediate Risk Population, and Valve in Valve Therapy Alan Zajarias, MD FACC Structural Interventional Fellowship Director Associate Professor Medicine Cardiovascular Division
More informationTAVR in 2020: What is Next!!!!
TAVR in 2020: What is Next!!!! Vinod H. Thourani, MD Professor of Surgery Chairman, Department of Cardiac Surgery Medstar Heart and Vascular Institute Washington Hospital Center Washington, DC Disclosures
More informationThe SAPIEN 3 TAVI Advantage
Edwards SAPIEN 3 Valve The SAPIEN 3 TAVI Advantage... The SAPIEN 3 TAVI Advantage The clear choice for your patients and your TAVI program Advanced valve and system designed to simplify procedures Consistent
More informationCurrent Evidence in TAVI patients using ACURATE and LOTUS valves
Current Evidence in TAVI patients using ACURATE and LOTUS valves Giuseppe Tarantini, MD, PhD, FESC, Professor and Director of Interventional Cardiology University of Padua GISE President Potential conflicts
More informationAfter PARTNER 2A/S3i and SURTAVI: What is the Role of Surgery in Intermediate-Risk AS Patients?
After PARTNER 2A/S3i and SURTAVI: What is the Role of Surgery in Intermediate-Risk AS Patients? Vinod H. Thourani, MD Professor of Surgery and Medicine Emory University Disclosure Statement of Financial
More informationTAVR IN INTERMEDIATE-RISK PATIENTS
TAVR IN INTERMEDIATE-RISK PATIENTS K. Lampropoulos MD, PhD, FESC, MEAPCI Interventional Cardiologist Evangelismos General Hospital The Burden of Valve Disease Prevalence Survival NATURAL HISTORY OF AS
More informationStrokes After TAVR Reasons for Declining Frequency
Strokes After TAVR Reasons for Declining Frequency Samir Kapadia, MD Professor of Medicine Director, Cardiac Catheterization Laboratory Cleveland Clinic Disclosure NONE Second Generation Valves Newer
More informationTAVR for Complex Aortic Valvular Conditions
TAVR for Complex Aortic Valvular Conditions Wilson Y. Szeto, MD Professor of Surgery Chief, Cardiovascular Surgery at Penn Presbyterian Surgical Director, Transcatheter Cardio-Aortic Therapies Associate
More informationTAVR in Intermediate Risk Populations /Optimizing Systems for TAVR
TAVR in Intermediate Risk Populations /Optimizing Systems for TAVR Saibal Kar, MD, FACC, FAHA, FSCAI Professor of Medicine Director of Interventional Cardiac Research Smidt Heart Institute, Cedars-Sinai
More informationIncorporating the intermediate risk in Transcatheter Aortic Valve Implantation (TAVI)
Incorporating the intermediate risk in Transcatheter Aortic Valve Implantation (TAVI) Larry S. Dean, MD, MSCAI Past President SCAI Professor of Medicine and Surgery University of Washington School of Medicine
More informationSAPIEN 3: Evaluation of a Balloon- Expandable Transcatheter Aortic Valve in High-Risk and Inoperable Patients With Aortic Stenosis One-Year Outcomes
SAPIEN 3: Evaluation of a Balloon- Expandable Transcatheter Aortic Valve in High-Risk and Inoperable Patients With Aortic Stenosis One-Year Outcomes Howard C. Herrmann, MD on behalf of The PARTNER II Trial
More informationTAVI and TAVR: Radical and Revolutionary: The Newest Insights for the CV Community and a Panel Discussion
TAVI and TAVR: Radical and Revolutionary: The Newest Insights for the CV Community and a Panel Discussion Moderator: Joseph E. Bavaria, MD Roberts-Measey Professor of Surgery Vice Chair, Division of Cardiovascular
More informationTranscatheter Aortic Valve Replacement with a Self-Expanding Prosthesis or Surgical Aortic Valve Replacement in Intermediate-Risk Patients:
Transcatheter Aortic Valve Replacement with a Self-Expanding Prosthesis or Surgical Aortic Valve Replacement in Intermediate-Risk Patients: 1-Year Results from the SURTAVI Clinical Trial Nicolas M. Van
More information2/15/2018 DISCLOSURES OBJECTIVES. Consultant for BioSense Webster, a J&J Co. Aortic stenosis background. Short history of TAVR
TRANSCATHETER AORTIC VALVE REPLACEMENT IN 2018: IS IT NOW THE STANDARD OF CARE? 22 ND ANNUAL COASTAL CARDIAC & VASCULAR CONFERENCE FEBRUARY 17, 2018 R. David Anderson, MD, MS, FACC, FSCAI Professor of
More informationTAVR 2018: TAVR has high clinical efficacy according to baseline patient risk! ii. Con
TAVR 2018: TAVR has high clinical efficacy according to baseline patient risk! ii. Con Dimitrios C. Angouras, MD, FETCS Associate Professor of Cardiac Surgery National and Kapodistrian University of Athens,
More informationA Thoughtful Synthesis of the TAVR Landscape: What s New, What s Needed and is There a Best-in-Class?
TVT Chicago Thursday 16th of June 2016 Session 1: TAVR 2016 Highlights and Controversies A Thoughtful Synthesis of the TAVR Landscape: What s New, What s Needed and is There a Best-in-Class? Ian T. Meredith
More informationTranscatheter Aortic Valve Implantation. SSVQ November 23, 2012 Centre Mont-Royal 15:40
Transcatheter Aortic Valve Implantation SSVQ November 23, 2012 Centre Mont-Royal 15:40 Nicolo Piazza MD, PhD, FRCPC, FESC, FACC McGill University Health Center German Heart Center Munich 1 First-in-Human
More informationEvolving and Expanding Indications for TAVR
Evolving and Expanding Indications for TAVR Wilson Y. Szeto, MD Associate Professor of Surgery Surgical Director, Transcatheter Cardio-Aortic Therapies Associate Director, Thoracic Aortic Surgery Division
More informationAortic Stenosis: Open vs TAVR vs Nothing
Aortic Stenosis: Open vs TAVR vs Nothing Wilson Y. Szeto, MD Associate Professor of Surgery Surgical Director, Transcatheter Cardio-Aortic Therapies Associate Director, Thoracic Aortic Surgery Division
More informationUpdate on TAVR. Howard C. Herrmann, MD, FACC, MSCAI
Update on TAVR Howard C. Herrmann, MD, FACC, MSCAI John Bryfogle Professor of Cardiovascular Medicine and Surgery Health System Director for Interventional Cardiology Director, Cardiac Cath Labs, Hospital
More informationTAVR in 2017 What we know? What to expect?
Journal of Geriatric Cardiology (2018) 15: 55 60 2018 JGC All rights reserved; www.jgc301.com Perspective Open Access TAVR in 2017 What we know? What to expect? Panagiota Kourkoveli 1,*, Konstantinos Spargias
More informationTAVR for low-risk patients in 2017: not so fast.
TAVR for low-risk patients in 2017: not so fast. Enrico Ferrari, MD, FETCS Cardiac Surgery Department Cardiocentro Ticino Foundation Lugano, Switzerland Conflicts of Interest Consultant and proctor for
More informationTAVI: The Real Deal? Marc Pelletier, MD Head, Department of Cardiac Surgery New Brunswick Heart Centre
TAVI: The Real Deal? Marc Pelletier, MD Head, Department of Cardiac Surgery New Brunswick Heart Centre Disclosure St. Jude Medical: Consultant and Proctor Edwards Lifesciences: Proctor Medtronic: Research
More informationAortic Stenosis: Background
Transcatheter Aortic Valve Replacement in Low Surgical Risk Patients Barry George, MD The Ohio State University Structural Heart Disease Course May 19 th, 2017 Aortic Stenosis: Background Severe Symptomatic
More informationAortic Valve Controversies Beyond risk assessment: TAVI for Everybody
Aortic Valve Controversies Beyond risk assessment: TAVI for Everybody Anna Sonia Petronio, MD, FESC Head of Cardiac Catheteriza8on Lab Cardiothoracic and Vascular Department University of Pisa, Italy 1.
More informationLOW RISK TAVR. WHAT THE FUTURE HOLDS
LOW RISK TAVR. WHAT THE FUTURE HOLDS Michael J. Reardon, M.D. Professor of Cardiothoracic Surgery Allison Family Distinguish Chair of Cardiovascular Research Houston Methodist DeBakey Heart & Vascular
More informationTissue vs Mechanical What s the Data??
Biological (Tissue) Valve in a 60 year old patient: Debate Tissue vs Mechanical What s the Data?? Joseph E. Bavaria, MD Immediate-Past President - Society of Thoracic Surgeons (STS) Brooke Roberts-William
More informationCurrent Controversies. Subclinical and clinical valve thrombosis
Chapter 19: Current controversies, ongoing trials, new valves, and future directions Sukhdeep S. Basra, MD, MPH, Michael J. Mack, MD The Heart Hospital Baylor Plano, Texas Transcatheter Aortic Valve Replacement
More informationRANDOMISED TRIALS TAVI WITH SAVR STEPHAN WINDECKER AORTIC VALVE DISEASE COMPARING
AORTIC VALVE DISEASE RANDOMISED TRIALS COMPARING TAVI WITH SAVR STEPHAN WINDECKER DEPARTMENT OF CARDIOLOGY SWISS CARDIOVASCULAR CENTER AND CLINICAL TRIALS UNIT BERN BERN UNIVERSITY HOSPITAL, SWITZERLAND
More informationIndication, Timing, Assessment and Update on TAVI
Indication, Timing, Assessment and Update on TAVI Swedish Heart and Vascular Institute Ming Zhang MD PhD Interventional Cardiology Structure Heart Disease Conflict of Interest None Starr- Edwards Mechanical
More informationTranscatheter aortic valve replacement in intermediate and low risk patients-clinical evidence
Perspective Transcatheter aortic valve replacement in intermediate and low risk patients-clinical evidence Sameer Arora, John P. Vavalle Division of Cardiology, University of North Carolina School of Medicine,
More informationNeal Kleiman, MD Houston Methodist DeBakey Heart and Vascular Institute
Neal Kleiman, MD Houston Methodist DeBakey Heart and Vascular Institute Despite a 33 fold growth in the first five years, there is still tremendous variability among penetration in different countries
More informationLotus Valve System for Transcatheter Aortic Valve Implantation/Replacement (TAVI/R) Evidence
X Congreso Coilegio Colombiano Santiago de Cali, 29-31 Octubre des 2014 Lotus Valve System for Transcatheter Aortic Valve Implantation/Replacement (TAVI/R) Evidence Eberhard Grube MD, FACC, FSCAI University
More informationTrans Aortic Valve Replacement Update: 2016 & Beyond
Trans Aortic Valve Replacement Update: 2016 & Beyond Rajiv Jauhar, MD, FACC, FSCAI Chief of Cardiology Director of Cardiac Cath Labs Northshore University Hospital, Manhasset 1 DISCLOSURE POLICY Northwell
More informationTAVR or SAVR A glimpse into the future
TAVR or SAVR A glimpse into the future Örjan Friberg Örebro University Hospital Sweden Prediction is very difficult, especially if it s about the future. Niels Bohr None Conflicts of interest If In the
More informationTranscatheter Valve Replacement: Current State in 2017
Transcatheter Valve Replacement: Current State in 2017 Marc A. Sintek MD Assistant Professor of Medicine Interventional Cardiology Cardiovascular Division Washington University in St. Louis Missouri ACP
More informationSurgical aortic valve replacement (SAVR)
DAVID L. BROWN, MD The Heart Hospital Baylor Plano, Baylor Scott & White Health, Plano, TX Expanding indications for TAVR: The preferred procedure in intermediate-risk patients? ABSTRACT Transcatheter
More informationAortic Stenosis: Interventional Choice for a 70-year old- SAVR, TAVR or BAV? Interventional Choice for a 90-year old- SAVR, TAVR or BAV?
Aortic Stenosis: Interventional Choice for a 70-year old- SAVR, TAVR or BAV? Interventional Choice for a 90-year old- SAVR, TAVR or BAV? Samin K Sharma, MD, FACC, FSCAI Director Clinical & Interventional
More information30-Day Outcomes Following Implantation of a Repositionable Self-Expanding Aortic Bioprosthesis: First Report From the FORWARD Study
30-Day Outcomes Following Implantation of a Repositionable Self-Expanding Aortic Bioprosthesis: First Report From the Study Stephan Windecker Department of Cardiology Bern University Hospital - INSELSPITAL
More informationEdwards Sapien. Medtronic CoreValve. Inoperable FDA approved High risk: in trials. FDA approved
Transcatheter Aortic Valve Replacement Symptomatic Aortic Stenosis Asymptomatic Juan Crestanello, MD Interim Director, Division of Cardiac Surgery Associate Professor Division of Cardiac Surgery The Ohio
More informationResults of Transfemoral Transcatheter Aortic Valve Implantation
Results of Transfemoral Transcatheter Aortic Valve Implantation Saudi Heart Association, February 21-24 Rüdiger Lange, MD, PhD Nicolo Piazza, MD, FRCPC, FESC German Heart Center, Munich, Germany Division
More informationTranscatheter Heart Valve Therapy
Edwards Lifesciences 2017 Investor Conference Transcatheter Heart Valve Therapy Larry L. Wood Corporate Vice President, Transcatheter Heart Valves Leader in ~$3B Global Transcatheter Heart Valves Primary
More informationThe TAVI Journey: Update on Evidence And Future trials
The TAVI Journey: Update on Evidence And Future trials Philippe Généreux, MD Interventional Cardiologist, Hôpital du Sacré-Coeur de Montréal, Canada Director, Angiographic Core Laboratory, Cardiovascular
More informationPARTNER 2A & SAPIEN 3: TAVI for intermediate risk patients
O P E N A C C E S S Department of Cardiology, Aswan Heart Centre *Email: ahmed.elguindy@aswanheartcentre.com Lessons from the trials PARTNER 2A & SAPIEN 3: TAVI for intermediate risk patients Ahmed ElGuindy*
More informationShould We Reconsider using Anticoagulation for Biological Tissue Valves
Should We Reconsider using Anticoagulation for Biological Tissue Valves No Disclosures Disclosures Watching grass grow Complete with audio 1 hour 8 minutes 9884 views Subclinical Leaflet Thrombosis in
More informationTranscatheter heart valve thrombosis
Transcatheter heart valve thrombosis Jeroen J Bax Dept Cardiology Leiden, The Netherlands New York, 2017 The department of Cardiology of the Leiden University Medical center received research grants from
More informationTranscatheter Aortic Valve Replacement: Current and Future Devices: How do They Work, Eligibility, Review of Data
Transcatheter Aortic Valve Replacement: Current and Future Devices: How do They Work, Eligibility, Review of Data Echo Florida 2013 Jonathan J. Passeri, M.D. Co-Director, Heart Valve Program Director,
More information1-YEAR OUTCOMES FROM JOHN WEBB, MD
1-YEAR OUTCOMES FROM JOHN WEBB, MD ON BEHALF OF THE SAPIEN 3 INVESTIGATORS UNIVERSITY OF BRITISH COLUMBIA VANCOUVER, CANADA Potential conflicts of interest Speaker's name: John Webb I have the following
More informationStrokes After TAVR. Ioannis Iakovou, MD, PhD. Interventional Cardiology Onassis Cardiac Surgery Center
Strokes After TAVR Ioannis Iakovou, MD, PhD Interventional Cardiology Onassis Cardiac Surgery Center Strokes After TAVR How common is stroke after TAVR Is it increasing? Is it more with TF vs TA? Is it
More informationAccepted Manuscript. Sixteen Years Later and the Debate for TAVR or SAVR Remains Controversial. Saina Attaran, MD, Vinod H.
Accepted Manuscript Sixteen Years Later and the Debate for TAVR or SAVR Remains Controversial Saina Attaran, MD, Vinod H. Thourani, MD PII: S0022-5223(18)30624-X DOI: 10.1016/j.jtcvs.2018.02.080 Reference:
More informationRole of Embolic Protection during TAVR
Role of Embolic Protection during TAVR Samir Kapadia, MD Professor of Medicine Section head, Interventional Cardiology Director, Cardiac Catheterization Laboratories Disclosure Co PI for Sentinel Trial
More informationProgress In Transcatheter Aortic Valve Implantation
Progress In Transcatheter Aortic Valve Implantation Gerald Yong MBBS (Hons) FRACP FSCAI Interventional Cardiologist Royal Perth Hospital Western Australia 4 th APCASH 8 th Sept 2013 Disclosure Statement
More informationDisclosures 4/16/2018. What s New in Valvularand Structural Heart Disease. None relevant to the presentation
What s New in Valvularand Structural Heart Disease Ryan C. Shelstad, MD Surgical Enthusiast, Valvular and Structural Heart Disease Bryan Heart Cardiothoracic Surgery Disclosures None relevant to the presentation
More informationL evoluzione nel management della valvulopatia aortica
L evoluzione nel management della valvulopatia aortica Giuseppe Tarantini, MD, PhD, FESC Director of Interventional Cardiology University of Padua GISE president TAVI: BIG BANG 2002 TAVI - EVOLUTIONs Commitment
More informationFederico M Asch MD, FASE MedStar Heart and Vascular Institute Georgetown University Washington, DC
TAVR: When Things go Wrong Federico M Asch MD, FASE MedStar Heart and Vascular Institute Georgetown University Washington, DC Disclosures Academic Echo Core Lab Abbott / St Jude Medical Edwards Medtronic
More informationState of the Art and Future perspective
State of the Art and Future perspective Giuseppe Tarantini, MD, PhD, FESC Associate professor University of Padua Director Interventional Cardiology Dpt of Cardiac Thoracic and Vascular Sciences, Padua
More informationStrokes After TAVR: Perspectives from the US CoreValve Trials
Strokes After TAVR: Perspectives from the US CoreValve Trials Jeffrey J. Popma, MD Professor of Medicine Harvard Medical School Director, Interventional Cardiology Clinical Services Beth Israel Deaconess
More informationEmergency TAVI: Does It Exist? Is the Risk Higher?
Emergency TAVI: Does It Exist? Is the Risk Higher? Gerald Yong MBBS (Hons) FRACP FSCAI Interventional Cardiologist Royal Perth Hospital Western Australia APCASH 12 October 2014 Disclosure Statement of
More informationIan T. Meredith AM. MBBS, PhD, FRACP, FCSANZ, FACC, FAPSIC. Monash HEART, Monash Health & Monash University Melbourne, Australia
Two-Year Outcomes With the Fully Repositionable and Retrievable Lotus Transcatheter Aortic Replacement Valve in 120 High-Risk Surgical Patients With Severe Aortic Stenosis: Results From the REPRISE II
More informationExtension to medium and low risk patients? Friedrich Eckstein University Hospital Basel
TAVI CON Extension to medium and low risk patients? Friedrich Eckstein University Hospital Basel Extension to medium and low risk patients? In octogenerians already reality in most of the swiss clinics!?
More informationAppropriate Use of TAVR - now and in the future. A Surgeon s Perspective. Neil Moat Royal Brompton Hospital, London, UK
Appropriate Use of TAVR - now and in the future A Surgeon s Perspective Neil Moat Royal Brompton Hospital, London, UK Disclosure Statement of Financial Interest Within the past 12 months, I or my spouse/partner
More informationTranscatheter Aortic Valve Implantation (TAVI) Overview for Wales. Dr Richard Anderson University Hospital of Wales, Cardiff, UK
Transcatheter Aortic Valve Implantation (TAVI) Overview for Wales Dr Richard Anderson University Hospital of Wales, Cardiff, UK Aortic stenosis is a disease of old age Age demographics in Wales % Wales
More informationUsing STS/ACC TVT Registry Data for Quality Improvement (QI) Learning Objectives. Overview 3/12/2014
Using STS/ACC TVT Registry Data for Quality Improvement (QI) March 27, 2014 Kim Marshall BSN, RN Quality Improvement Specialist We Improve Lives Learning Objectives Sources for data analysis for Transcatheter
More informationAn Update on the Edwards TAVR Results. Zvonimir Krajcer, MD Director, Peripheral Intervention Texas Heart Institute at St.
An Update on the Edwards TAVR Results Zvonimir Krajcer, MD Director, Peripheral Intervention Texas Heart Institute at St. Luke s Hospital Disclosures On the speaker s bureau for Endologix, TriVascular,
More informationTAVR Samir Kapadia, MD Professor of Medicine Director, Cardiac Catheterization Laboratory. Cleveland Clinic.
TAVR 2015 Samir Kapadia, MD Professor of Medicine Director, Cardiac Catheterization Laboratory Outline Aortic Stenosis TAVR Who should be considered for TAVR What are the treatment options? Valves, Approaches
More informationDisclosures. LGH TAVR: Presentation Outline 2/2/2016. Updates in Transcatheter Aortic Valve Replacement (TAVR) and the LGH Experience
Updates in Transcatheter Aortic Valve Replacement (TAVR) and the LGH Experience The LGH TAVR Program James E. Harvey, MD, MSc Medical Director, Structural Heart Intervention The Heart Group of Lancaster
More informationClinical and Echocardiographic Outcomes at 30 Days with the SAPIEN 3 TAVR System in Inoperable, High-Risk and Intermediate-Risk AS Patients
Clinical and Echocardiographic Outcomes at 30 Days with the SAPIEN 3 TAVR System in Inoperable, High-Risk and Intermediate-Risk AS Patients Susheel Kodali, MD on behalf of The PARTNER Trial Investigators
More informationTranscatheter Aortic-Valve Implantation for Aortic Stenosis
Transcatheter Aortic-Valve Implantation for Aortic Stenosis Policy Number: 7.01.132 Last Review: 2/2019 Origination: 2/2012 Next Review: 2/2020 Policy Blue Cross and Blue Shield of Kansas City (Blue KC)
More informationTAVI: FUTURE DEVELOPMENTS
4 th Aortic Live Symposium TAVI: FUTURE DEVELOPMENTS Volkmar Falk Disclosure Speaker name: Volkmar Falk... I have the following potential conflicts of interest to report: Consulting: Aesculap Employment
More informationUpdate on Percutaneous Therapies for Structural Heart Disease. William Thomas MD Director of Structural Heart Program Tucson Medical Center
Update on Percutaneous Therapies for Structural Heart Disease William Thomas MD Director of Structural Heart Program Tucson Medical Center NCVH 2014- Tucson Disclosure of Financial Interest Research: Stock
More informationAntithrombotic. DAPT or OAC?
Antithrombotic treatment after TAVI: DAPT or OAC? Striking the right balance. Pascal Vranckx MD, PhD. Hartcentrum Hasselt, Belgium. Disclosure of Interest Pascal Vranckx has the following potential conflicts
More informationHow Do I Evaluate a Patient Being Considered for TAVR? Sunday, February 14, :00 11:25 PM 25 min
2016 ASE State of the Art Echocardiography Course Tucson, AZ How Do I Evaluate a Patient Being Considered for TAVR? Sunday, February 14, 2016 11:00 11:25 PM 25 min 1 M U H A M E D S A R I Ć, M D, P H D
More informationIs Stroke Frequency Declining?
Is Stroke Frequency Declining? Etiologic Factors Clinical, Anatomic, Technique-related, and Device-specific Samir Kapadia, MD Professor of Medicine Section head, Interventional Cardiology Director, Cardiac
More informationTranscatheter aortic valve replacement with the SAPIEN 3 valve: preparing the field for the final expansion
Editorial Transcatheter aortic valve replacement with the SAPIEN 3 valve: preparing the field for the final expansion Jean-Michel Paradis, Josep Rodés-Cabau Quebec Heart & Lung Institute, Quebec City,
More informationOutcomes in the Commercial Use of Self-expanding Prostheses in Transcatheter Aortic Valve Replacement: A Comparison of the Medtronic CoreValve and
Outcomes in the Commercial Use of Self-expanding Prostheses in Transcatheter Aortic Valve Replacement: A Comparison of the Medtronic CoreValve and Evolut R platforms in the Society of Thoracic Surgeons/American
More informationTAVI After PARTNER-2 : The Hamilton Approach
TAVI After PARTNER-2 : The Hamilton Approach James L. Velianou MD FRCPC Interventional Cardiology Hamilton General Hospital St Catharines General Hospital Associate Professor of Medicine McMaster University
More informationTranscatheter Heart Valve Procedures
Medical Coverage Policy Transcatheter Heart Valve Procedures Table of Contents Coverage Policy... 1 Overview... 2 General Background... 2 Coding/Billing Information... 27 References... 29 Effective Date...11/15/2017
More information3 years after introduction of TAVI in QEH. Michael KY Lee On Behalf of QEH TAVI Heart Team Queen Elizabeth Hospital Hong Kong
3 years after introduction of TAVI in QEH Michael KY Lee On Behalf of QEH TAVI Heart Team Queen Elizabeth Hospital Hong Kong HA Convention 2014 Introduction Aortic Stenosis most common valvular heart disease
More informationTranscatheter procedures of the future; expanding the treatment options for patients with severe aortic stenosis
Transcatheter procedures of the future; expanding the treatment options for patients with severe aortic stenosis John Webb MD Director interventional cardiology, St Paul s Hospital McLeod Professor of
More informationTAVI Technology and Procedural Changes
TCT AP 2013 Seoul, South Korea April, 2013 TAVI Technology and Procedural Changes Eberhard Grube MD, FACC, FSCAI University Hospital, Dept of Medicine II, Bonn, Germany Hospital Alemão Oswaldo Cruz, São
More informationCoreValve in a Degenerative Surgical Valve
CoreValve in a Degenerative Surgical Valve Ran Kornowski, MD, FESC, FACC Chairman Department of Cardiology Rabin Medical Center, Petach Tikva, Israel Disclosure Statement of Financial Interest I, Ran Kornowski,
More informationTranscatheter Aortic Valve Implantation (TAVI) - 5 important lessons learnt from HK experiences Michael KY Lee
Transcatheter Aortic Valve Implantation (TAVI) - 5 important lessons learnt from HK experiences Michael KY Lee Queen Elizabeth Hospital, Hong Kong President, HKSTENT APCASH 2013 SJ Park TAVI Summit 2013
More informationAndrzej Ochala, MD Medical University of Silesia, Katowice, Poland
Andrzej Ochala, MD Medical University of Silesia, Katowice, Poland Bicuspid aortic valve o Most common congenital heart disease in adults (1% - 2%) o AS is the most common complication of BAV o Patophysiology
More informationTAVR 2015: A Breakthrough Technology GOES VIRAL! Issues and Controversies. Martin B. Leon, MD
TAVR 2015: A Breakthrough Technology GOES VIRAL! Issues and Controversies Martin B. Leon, MD Columbia University Medical Center Cardiovascular Research Foundation New York City Disclosure Statement of
More information