Sudden death as co-morbidity in patients following vascular intervention
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1 Sudden death as co-morbidity in patients following vascular intervention Impact of ICD therapy Seah Nisam Director, Medical Science, Guidant Corporation Advanced Angioplasty Meeting (BCIS) London, 16 Jan, 2003
2 What am I doing here??
3 Epidemiology of sudden cardiac death Sudden cardiac death (SCD) due to coronary artery disease (CAD) is the single most important cause of death in the adult population of the industrialized world 1 Incidence in Western Europe (similar to US): SCD/Y 75-80% due to VT/VF 5-10% due to bradyarrhythmias Out-of-hospital SCD: 8 per 1000 for males between years old and a prior history of heart disease Priori S. European Heart Journal Carveth. Surg Vertesi L. Can Med Assoc J Bachman JW. JAMA Becker. Ann Emerg Med 1993.
4 SCD in Myocardial infarction 1 Pre-thrombolytic era: Expected mortality after MI ~ 15% at 2.5 years, with ~75% of all deaths being arrhythmic 2 Thrombolytic era: Incidence of cardiac deaths after MI ~ 5% at 2.5 years, with 50% being arrhythmic; VT/VF without preceding ischemia can be expected in 0.5% to 2.5 of patients 3,4 In post MI at high risk (EMIAT, CAMIAT, TRACE, DIAMOND-MI, SWORD), cumulative arrhythmic mortality ~ 5% at 1 Y and 9% at 2y 1 Priori S. European Heart Journal Marcus. AM J Cardiol Statters. Am J Cardiol 1996; 4 Hohnloser S. JACC 1999.
5 Great majority of patients in the large ICD trials have CAD and previous CABG/PTCA MADIT (n = 196) MUSTT (n = 704) MADIT II (n = 1232) AVID (n = 1016) Age % Males LVEF NYHA II/III (%) Coronary Artery disease (%) Previous CABG/PTCA (%) Mean time post-mi to enrolment (mos) /44 ~ 50/? (of CAD pts) > 36 N/A
6 Probability of Survival MADIT & MUSTT: ICD reduces mortality by > 50% MUSTT MADIT ICD MUSTT no Tx MUSTT drug Tx MADIT Conventional Tx Control Hazard ratio: MADIT 0.46 (p =0.009); MUSTT: 0.49 (p = 0.001) Prystowsky /Nisam (AJC 2000)
7 ICDs reduce mortality by ~ 40% in primary prevention as well as in secondary 73% 54% 51% 39% 20% 38% 31% 0 Control ICD 10 0 AVID CIDS DUTCH CES CASH MUSTT MADIT CABG- Patch MADIT II Secondary Prevention Studies Primary Prevention Studies
8 CABG-Patch trial (n = 900) Patients requiring CABG, with LVEF < 0.35, were randomized at time of CABG to ICD or no ICD Patients had no previous history of sustained ventricular arrhythmias (VT/VF) Only arrhythmia risk stratifier was signal averaged ECG (SAECG)
9 Why no ICD benefit in CABG-Patch? CABG - for patients requiring and amenable to surgery - is highly effective against mortality and arrhythmias Mortality 30 days post CABG was only 11% in following 2 years SAECG (only arrhythmia risk stratifier in CABG-Patch) not a strong one Risk stratification (SAECG and LVEF) measured before CABG Of all the ICD studies, the only one enrolling patients without sustained VT/VF (either spontaneous or inducible) was CABG-Patch Main lesson from CABG-Patch study: patients without sufficient arrhythmia risk do not benefit from ICD therapy
10 MADIT II Inclusion/Exclusion Criteria Inclusion criteria MI > 4 weeks LVEF < 30% > 21 years Exclusion criteria Previous cardiac arrest Sustained VT NYHA Class IV CABG or PTCA < 3 months CABG or PTCA planned Life-threatening diseases < 21 years
11 CABG ICD pts.(n = 18) Other ICD pts. (n = 232) Geelen & Brugada PACE 1999;22:
12 Appropriate ICD discharges in patients post CABG (n = 412) Daoud et al American Heart Journal 1995;130:277-80
13 ACC/AHA/NASPE 1 and ESC 2 Guidelines new recommendations for ICD indications Class IIa Patients with LV ejection fraction of less than or equal to 30%, at least one month post myocardial infarction and three months post coronary artery revascularization surgery 1. Gregaratorios, CIRC Oct 15, Priori, Eur H J, Jan 2003
14 Conclusions Over 80% of patients receiving ICDs have previous M.I. Nearly all CAD patients undergo CABG or PTCA before ICD implantation High percentage of patients receive ICD shocks despite revascularization ICDs reduce all-cause mortality by ~ 40% compared to controls in randomized clinical trials Risk for Sudden death and arrhythmias remains high despite revascularization, and these patients receive significant benefits from ICDs
15 MADIT II medications at last follow-up: optimal and well-matched for both groups CONV (n=490) ICD (n=742) percent Beta-blockers ACE inhibitors Diuretics Digitalis Statins Amiodarone* Antiarrhythmics 2 3 * Principally for control of supraventricular arrhythmias (AF)
16 MADIT II study overview ICD (742) R * Follow-up (average ~ 2 y.) 1232 pts. Optimal medical therapy No-ICD (490) 1232 patients enrolled from 76 centers (75 in U.S., 5 in Europe), from 7/97 to 11/2001 MADIT-II eligibility: Prior MI, ejection fraction < 30% No previous cardiac arrest or sustained VT Randomization 3:2 ICD:control (for analysis of secondary endpoints) Sponsor: Guidant corporation (unrestricted grant and ICDs used in study) *Randomization 3:2 (ICD:Control)
17 MADIT II showed 31% reduction of total mortality in post-mi patient with depressed LV function ICD benefit over and above optimal drug therapy ICD benefit similar in all important subgroups: age, LVEF, NYHA Class, time from MI, etc. A Moss. NEJM 2002
18 All-cause Mortality Mortality reduction with ICD in MADIT II is higher than major trials that have changed medical practice 30% 25% 20 % 31 % 20% 15% 27 % 11 % 10% 5% 0% β-blockers ACE inhibitors CABG ICDs Trial: BHAT SAVE CASS MADIT II N: P-value: n.s Courtesy A. Moss, 2002
19 CABG Patch Survival Curves Main study Pilot study Hypothesis (Control Group) 40
20 European Heart Journal (2001) 22, Working Group Report Indications for implantable cardioverter defibrillator (ICD) therapy Study Group on Guidelines on ICDs of the Working Group on Arrhythmias and the Working Group on Cardiac Pacing of the European Society of Cardiology R.N.W. Hauer (chair), E. Aliot, M. Block, A. Capucci, B. Lüderitz, M. Santini and P.E. Vardas «Prophylactic indication: Non-sustained VT 4 days or more after myocardial infarction with a left ventricular ejection fraction < 40% and inducible VF or sustained VT at electrophysiological study»
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