Common Terminology Criteria for Adverse Events

Transcription

1 Common Terminology Criteria for Adverse Events Version 3.0 Index NATIONAL INSTITUTES OF HEALTH 10/22/2003

2 -- A -- abdomen Adrenal insufficiency Colitis Distension/bloating, abdominal Enteritis (inflammation of the small bowel) Fistula, GI -- Typhlitis (cecal inflammation) Hemorrhage, GI HEPATOBILIARY/PANCREAS Liver dysfunction/failure (clinical) Pancreatitis VASCULAR Portal vein flow abducens See: CN VI HEPATOBILIARY/PANCREAS Pancreatitis Colitis, infectious (e.g., Clostridium difficile) Infection with unknown ANC -- Soft tissue necrosis -- Intra-operative injury abnormal BLOOD/BONE MARROW Myelodysplasia CONSTITUTIONAL SYMPTOMS Odor (patient odor) Neuroendocrine: ADH secretion abnormality (e.g., SIADH or low ADH) Neuroendocrine: gonadotropin secretion abnormality Neuroendocrine: growth hormone secretion abnormality Neuroendocrine: prolactin hormone secretion abnormality Fistula, GI abdominal pain Ascites (non-malignant) Colitis Gastritis (including bile reflux gastritis) Heartburn/dyspepsia Typhlitis (cecal inflammation) Ulcer, GI GROWTH AND DEVELOPMENT Bone age (alteration in bone age) Viral hepatitis Extremity-lower (gait/walking) abdomen - abnormal 2 of 133

3 -- A -- Pyramidal tract dysfunction (e.g., increased tone, hyperreflexia, positive Babinski, decreased fine motor coordination) abrasion Keratitis (corneal inflammation/corneal ulceration) Fistula, pulmonary/upper respiratory -- Fistula, GU -- SEXUAL/REPRODUCTIVE FUNCTION Breast function/lactation Orgasmic dysfunction Rash: dermatitis associated with radiation accentuation GROWTH AND DEVELOPMENT Bone growth: spine kyphosis/lordosis access-related Pulmonary embolism VASCULAR Thrombosis/embolism (vascular access-related) accessory nerve See: CN XI achalasia Dysphagia (difficulty swallowing) Esophagitis abscess Colitis Fistula, GI -- Proctitis acid Uric acid, serum-high (hyperuricemia) "Retinoic acid syndrome" HEPATOBILIARY/PANCREAS Pancreatitis Infection with unknown ANC -- absorption HEPATOBILIARY/PANCREAS Pancreas, exocrine enzyme deficiency acidemia See: acidosis acidosis Febrile neutropenia (fever of unknown origin without clinically or microbiologically documented infection)(anc <1.0 x 10e9/L, fever >=38.5 degrees C) Infection with unknown ANC -- Opportunistic infection associated with >=Grade 2 abrasion - acidosis 3 of 133

4 -- A -- Lymphopenia Acidosis (metabolic or respiratory) Glucose, serum-high (hyperglycemia) Urinary electrolyte wasting (e.g., Fanconi's syndrome, renal tubular acidosis) Fanconi's syndrome Renal tubular acidosis acute vascular leak syndrome VASCULAR Adams-Stokes See: atrioventricular rhythm ADD Acute vascular leak syndrome ADD (Attention Deficit Disorder) Cognitive disturbance Confusion 70 acne/acneiform acrocyanosis COAGULATION ACTH Rash: acne/acneiform DIC (disseminated intravascular coagulation) Neuroendocrine: ACTH deficiency actinic keratosis Keratitis (corneal inflammation/corneal ulceration) acuity See: visual acuity acute infusion reaction Injection site reaction/extravasation changes Cytokine release syndrome/acute infusion reaction adenoviral ADH Infection with unknown ANC -- Opportunistic infection associated with >=Grade 2 Lymphopenia Viral hepatitis Neuroendocrine: ADH secretion abnormality (e.g., SIADH or low ADH) ADHD See: ADD adhesions Colitis Enteritis (inflammation of the small bowel) Fistula, GI -- adolescents acne/acneiform - adolescents 4 of 133

5 -- A -- AUDITORY/EAR adrenal Hearing: patients with/without baseline audiogram and enrolled in a monitoring program Hearing: patients without baseline audiogram and not enrolled in a monitoring program Adrenal insufficiency Masculinization of female Sodium, serum-low (hyponatremia) Intra-operative injury -- adrenocortical dysfunction Masculinization of female Neuroendocrine: ACTH deficiency aerodigestive Mucositis/stomatitis (functional/symptomatic) -- Infection with unknown ANC -- Intra-operative injury aguesia airway Cognitive disturbance Confusion Irritability (children <3 years of age) Mood alteration -- Personality/behavioral Psychosis (hallucinations/delusions) Taste alteration (dysgeusia) ALLERGY/IMMUNOLOGY Allergic rhinitis (including sneezing, nasal stuffiness, postnasal drip) Infection with unknown ANC -- Atelectasis Bronchospasm, wheezing Edema, larynx Fistula, pulmonary/upper respiratory -- Obstruction/stenosis of airway -- Prolonged intubation after pulmonary resection (>24 hrs after surgery) Intra-operative injury AGC See: ANC agitation albumin Viral hepatitis adrenal - albumin 5 of 133

6 -- A -- albuminuria alcohol Albumin, serum-low (hypoalbuminemia) Calcium, serum-low (hypocalcemia) Proteinuria GGT (gamma-glutamyl transpeptidase) Alcohol intolerance syndrome (antabuse-like syndrome) aldosterone Adrenal insufficiency alimentary tract Dry mouth/salivary gland (xerostomia) Malabsorption Mucositis/stomatitis (functional/symptomatic) -- Necrosis, GI alkalosis See: alkaline allergic Alkalosis (metabolic or respiratory) ALLERGY/IMMUNOLOGY Allergic reaction/hypersensitivity (including drug fever) Allergic rhinitis (including sneezing, nasal stuffiness, postnasal drip) Autoimmune reaction Serum sickness Vasculitis Bronchospasm, wheezing Edema, larynx Obstruction/stenosis of airway -- Cytokine release syndrome/acute infusion reaction alopecia See: hair Hair loss/alopecia (scalp or body) LYMPHATICS Edema: viscera Trismus (difficulty, restriction or pain when opening mouth) ALT Opportunistic infection associated with >=Grade 2 Lymphopenia Viral hepatitis Aspiration 56 ALT, SGPT (serum glutamic pyruvic transaminase) 40 alkaline Alkaline phosphatase 40 alveolitis Pneumonitis/pulmonary infiltrates 58 albuminuria - amblyopia 6 of 133

7 -- A -- amblyopia ambulation amenorrhea aminotransferase See: AST, ALT AML/MDS amnesia Vision-blurred vision Arthritis (non-septic) Extremity-lower (gait/walking) Joint-function Muscle weakness, generalized or specific area (not due to neuropathy) -- Neuroendocrine: prolactin hormone secretion abnormality SEXUAL/REPRODUCTIVE FUNCTION Irregular menses (change from baseline) ALT, SGPT (serum glutamic pyruvic transaminase) AST, SGOT(serum glutamic oxaloacetic transaminase) SECONDARY MALIGNANCY Secondary Malignancy - possibly related to cancer treatment (Specify, ) Memory impairment amputation ALLERGY/IMMUNOLOGY Vasculitis LYMPHATICS VASCULAR amylase Wound complication, non-infectious Dental: teeth Edema: limb Fibrosis-deep connective tissue Fracture Peripheral arterial ischemia HEPATOBILIARY/PANCREAS Liver dysfunction/failure (clinical) Pancreatitis Amylase anal See: anus Fistula, GI -- Incontinence, anal Stricture/stenosis (including anastomotic), GI -- Ulcer, GI -- Hemorrhage, GI -- Infection with unknown ANC amblyopia - anal 7 of 133

8 -- A -- See: anus Intra-operative injury -- anal/perianal See: anus Infection with unknown ANC -- anaphylaxis ALLERGY/IMMUNOLOGY Allergic reaction/hypersensitivity (including drug fever) Cytokine release syndrome/acute infusion reaction 1 68 BLOOD/BONE MARROW Neutrophils/granulocytes (ANC/AGC) CONSTITUTIONAL SYMPTOMS Fever (in the absence of neutropenia, where neutropenia is defined as ANC <1.0 x 10e9/L) Febrile neutropenia (fever of unknown origin without clinically or microbiologically documented infection)(anc <1.0 x 10e9/L, fever >=38.5 degrees C) Infection with unknown ANC -- Opportunistic infection associated with >=Grade 2 Lymphopenia Viral hepatitis anejaculation SEXUAL/REPRODUCTIVE FUNCTION Ejaculatory dysfunction anastomosis HEPATOBILIARY/PANCREAS ANC Dysphagia (difficulty swallowing) Leak (including anastomotic), GI -- Prolapse of stoma, GI Stricture/stenosis (including anastomotic), GI -- Biliary tree damage Stricture (biliary tree, hepatic or pancreatic) Leak (including anastomotic), GU -- Prolapse of stoma, GU Stricture/stenosis (including anastomotic), GU anemia ALLERGY/IMMUNOLOGY Autoimmune reaction BLOOD/BONE MARROW Hemoglobin Hemolysis (e.g., immune hemolytic anemia, drug-related hemolysis) COAGULATION Thrombotic microangiopathy (e.g., thrombotic thrombocytopenic purpura [TTP] or hemolytic uremic syndrome [HUS]) Hemorrhage, CNS Hemorrhage, GI anal/perianal - anemia 8 of 133

9 -- A -- angiitis angina Hemorrhage, GU -- Hemorrhage, pulmonary/upper respiratory -- Hemorrhage/bleeding associated with surgery, intraoperative or postoperative Petechiae/purpura (hemorrhage/bleeding into skin or mucosa) ALLERGY/IMMUNOLOGY Vasculitis VASCULAR Vessel injury-artery -- Vessel injury-vein -- CARDIAC GENERAL Cardiac ischemia/infarction Cardiac troponin I (ctni) Cardiac troponin T (ctnt) Hypotension anosmia Weight loss Adrenal insufficiency Anorexia Nausea Neuropathy: cranial -- antabuse Alcohol intolerance syndrome (antabuse-like syndrome) anti-androgens Alcohol intolerance syndrome (antabuse-like syndrome) anti-estrogens/androgens Tumor flare angioedema ALLERGY/IMMUNOLOGY Allergic reaction/hypersensitivity (including drug fever) ankylosed/fused Cervical spine-range of motion Lumbar spine-range of motion anti-osteoporotic See: osteoporosis anticoagulation COAGULATION Fibrinogen INR (International Normalized Ratio of prothrombin time) PTT (Partial Thromboplastin Time) Ano-rectal See: anus anorexia CONSTITUTIONAL SYMPTOMS VASCULAR Phlebitis (including superficial thrombosis) Thrombosis/embolism (vascular access-related) Thrombosis/thrombus/embolism angiitis - antiglobulin 9 of 133

10 -- A -- antiglobulin anxiety BLOOD/BONE MARROW Hemolysis (e.g., immune hemolytic anemia, drug-related hemolysis) antitussive Cough 4 56 Confusion Irritability (children <3 years of age) Memory impairment Mood alteration -- Personality/behavioral Psychosis (hallucinations/delusions) anuria anus Renal failure Urinary electrolyte wasting (e.g., Fanconi's syndrome, renal tubular acidosis) Fistula, GI -- Incontinence, anal Mucositis/stomatitis (clinical exam) -- Mucositis/stomatitis (functional/symptomatic) -- Necrosis, GI -- Stricture/stenosis (including anastomotic), GI -- Ulcer, GI -- Hemorrhage, GI -- Infection with unknown ANC aorta VASCULAR aphasia aphonic aplasia BLOOD/BONE MARROW apnea Intra-operative injury -- Vessel injury-artery -- Aphasia, receptive and/or expressive Dysphasia, receptive and/or expressive Speech impairment (e.g., dysphasia or aphasia) Voice changes/dysarthria (e.g., hoarseness, loss or alteration in voice, laryngitis) Bone marrow cellularity Apnea Hypoxia 57 Intra-operative injury -- appendix antiglobulin - appendix 10 of 133

11 -- A -- CARDIAC ARRHYTHMIA appetite Fistula, GI -- Necrosis, GI -- Perforation, GI -- Infection with unknown ANC -- Intra-operative injury -- Anorexia Nausea Conduction abnormality/atrioventricular heart block -- Palpitations Prolonged QTc interval Supraventricular and nodal arrhythmia -- Vasovagal episode Ventricular arrhythmia -- CARDIAC GENERAL Cardiac ischemia/infarction Left ventricular diastolic dysfunction Left ventricular systolic dysfunction Restrictive cardiomyopathy Right ventricular dysfunction (cor pulmonale) arsenic trioxide "Retinoic acid syndrome" arachnoiditis artery CARDIAC GENERAL Arachnoiditis/meningismus/radiculitis Cardiac ischemia/infarction 7 arcuate deficit ARDS areola Glaucoma Adult Respiratory Distress Syndrome (ARDS) Pneumonitis/pulmonary infiltrates Pulmonary fibrosis (radiographic changes) SEXUAL/REPRODUCTIVE FUNCTION Breast nipple/areolar deformity arrhythmia Infection with unknown ANC -- Intra-operative injury -- VASCULAR Peripheral arterial ischemia Vessel injury-artery -- Visceral arterial ischemia (non-myocardial) arthralgia appetite - arthralgia 11 of 133

12 -- A -- arthritis Arthritis (non-septic) Cytokine release syndrome/acute infusion reaction Arthritis (non-septic) arthrodesis Joint-function AST HEPATOBILIARY/PANCREAS Liver dysfunction/failure (clinical) Viral hepatitis AST, SGOT(serum glutamic oxaloacetic transaminase) asterixis HEPATOBILIARY/PANCREAS Liver dysfunction/failure (clinical) asthenia CONSTITUTIONAL SYMPTOMS Fatigue (asthenia, lethargy, malaise) Cytokine release syndrome/acute infusion reaction artificial tears ascites Dry eye syndrome Ascites (non-malignant) Viral hepatitis aspiration Hematoma Seroma Aspiration asystole See: atrioventricular rhythm ataxia Extremity-lower (gait/walking) Ataxia (incoordination) atelectasis Atelectasis atonia Colitis Muscle weakness, generalized or specific area (not due to arthritis - atonia 12 of 133

13 -- A -- atony atresia neuropathy) -- Urinary retention (including neurogenic bladder) SEXUAL/REPRODUCTIVE FUNCTION Vaginal stenosis/length atrioventricular rhythm CARDIAC ARRHYTHMIA Conduction abnormality/atrioventricular heart block -- Supraventricular and nodal arrhythmia aura Hearing: patients without baseline audiogram and not enrolled in a monitoring program Seizure autoimmune ALLERGY/IMMUNOLOGY AV block Autoimmune reaction CARDIAC ARRHYTHMIA Conduction abnormality/atrioventricular heart block Thyroid function, low (hypothyroidism) 18 AV node See: atrioventricular rhythm atrophy Atrophy, skin Atrophy, subcutaneous fat attention ADD (Attention Deficit Disorder) Cognitive disturbance Confusion Irritability (children <3 years of age) avascular Dental: periodontal disease GROWTH AND DEVELOPMENT Bone growth: femoral head; slipped capital femoral epiphysis Osteonecrosis (avascular necrosis) attenuation Leukoencephalopathy (radiographic findings) 49 audiogram AUDITORY/EAR Hearing: patients with/without baseline audiogram and enrolled in a monitoring program 2 atony - avascular 13 of 133

14 -- B -- Babinski Myelitis Pyramidal tract dysfunction (e.g., increased tone, hyperreflexia, positive Babinski, decreased fine motor coordination) balance See: CN VIII baldness banding behavior Extremity-lower (gait/walking) Neuropathy: cranial -- Hair loss/alopecia (scalp or body) Hemorrhoids Confusion Irritability (children <3 years of age) Mood alteration -- Personality/behavioral bicarbonate Bicarbonate, serum-low See: biliary biliary Fistula, GI -- Gastritis (including bile reflux gastritis) Leak (including anastomotic), GI -- Perforation, GI -- Stricture/stenosis (including anastomotic), GI -- HEPATOBILIARY/PANCREAS bilirubin Hemorrhage, GI -- Liver dysfunction/failure (clinical) Infection with unknown ANC -- Intra-operative injury -- HEPATOBILIARY/PANCREAS Liver dysfunction/failure (clinical) Bilirubin (hyperbilirubinemia) Urine color change bigeminy bile CARDIAC ARRHYTHMIA Ventricular arrhythmia -- 6 bladder Hemorrhage, GU -- Babinski - bladder 14 of 133

15 -- B -- Infection with unknown ANC -- Bladder spasms Cystitis Fistula, GU -- Leak (including anastomotic), GU -- Obstruction, GU -- Perforation, GU -- Stricture/stenosis (including anastomotic), GU -- Urinary retention (including neurogenic bladder) Ulcer, GI -- Hemorrhage, GI -- Hemorrhage, GU -- Hemorrhage, pulmonary/upper respiratory -- Hemorrhage/bleeding associated with surgery, intraoperative or postoperative Petechiae/purpura (hemorrhage/bleeding into skin or mucosa) Colitis, infectious (e.g., Clostridium difficile) Cystitis SEXUAL/REPRODUCTIVE FUNCTION Vaginal mucositis Intra-operative injury -- blepharitis bleeding Eyelid dysfunction COAGULATION DIC (disseminated intravascular coagulation) Thrombotic microangiopathy (e.g., thrombotic thrombocytopenic purpura [TTP] or hemolytic uremic syndrome [HUS]) Rash: dermatitis associated with radiation -- Rash: hand-foot skin reaction Colitis Dental: periodontal disease Enteritis (inflammation of the small bowel) Mucositis/stomatitis (clinical exam) -- Stricture/stenosis (including anastomotic), GI -- Typhlitis (cecal inflammation) blindness blisters Cataract Glaucoma Keratitis (corneal inflammation/corneal ulceration) Night blindness (nyctalopia) Optic disc edema Retinal detachment Retinopathy Scleral necrosis/melt Uveitis Photosensitivity Rash/desquamation bleeding - blisters of 133

16 -- B -- bloating Block-heart block See: atrioventricular rhythm blurred blush BM See: constipation BMD BMI CONSTITUTIONAL SYMPTOMS bone Rash: hand-foot skin reaction Constipation Heartburn/dyspepsia Vision-blurred vision Flushing Osteoporosis Obesity BLOOD/BONE MARROW Bone marrow cellularity Thyroid function, low (hypothyroidism) Dental: periodontal disease GROWTH AND DEVELOPMENT bowel Bone age (alteration in bone age) Bone growth: limb length discrepancy Bone growth: spine kyphosis/lordosis Bone growth: femoral head; slipped capital femoral epiphysis Infection with unknown ANC -- Bone: spine-scoliosis Exostosis Fracture Osteonecrosis (avascular necrosis) Osteoporosis Intra-operative injury -- Colitis Constipation Diarrhea Enteritis (inflammation of the small bowel) Fistula, GI -- Ileus, GI (functional obstruction of bowel, i.e., neuroconstipation) Incontinence, anal Leak (including anastomotic), GI bloating - bowel 16 of 133

17 -- B -- BP Mucositis/stomatitis (clinical exam) -- Mucositis/stomatitis (functional/symptomatic) -- Necrosis, GI -- Obstruction, GI -- Perforation, GI -- Stricture/stenosis (including anastomotic), GI -- Typhlitis (cecal inflammation) Ulcer, GI -- Hemorrhage, GI -- Infection with unknown ANC -- Intra-operative injury -- CARDIAC ARRHYTHMIA Vasovagal episode See: atrioventricular rhythm bradypnea HEPATOBILIARY/PANCREAS brain Liver dysfunction/failure (clinical) Apnea Infection with unknown ANC -- Arachnoiditis/meningismus/radiculitis Encephalopathy Seizure Speech impairment (e.g., dysphasia or aphasia) Intra-operative injury CARDIAC GENERAL Hypertension Hypotension Syncope (fainting) breast Feminization of male GROWTH AND DEVELOPMENT Puberty (precocious) 29 brachial Brachial plexopathy SEXUAL/REPRODUCTIVE FUNCTION Intra-operative injury -- bradycardia Breast function/lactation Breast nipple/areolar deformity Breast volume/hypoplasia Gynecomastia BP - breast of 133

18 -- B -- Intra-operative injury -- Bruising (in absence of Grade 3 or 4 thrombocytopenia) 14 bronchial buffalo hump Hemorrhage, pulmonary/upper respiratory -- Cushingoid appearance (e.g., moon face, buffalo hump, centripetal obesity, cutaneous striae) Infection with unknown ANC -- Atelectasis Fistula, pulmonary/upper respiratory -- Obstruction/stenosis of airway bullae burn Rash/desquamation Burn 14 Intra-operative injury -- bronchospasm ALLERGY/IMMUNOLOGY Allergic reaction/hypersensitivity (including drug fever) 1 BLOOD/BONE MARROW Hemolysis (e.g., immune hemolytic anemia, drug-related hemolysis) 4 Bronchospasm, wheezing 56 Cytokine release syndrome/acute infusion reaction 68 bruising COAGULATION Fibrinogen INR (International Normalized Ratio of prothrombin time) PTT (Partial Thromboplastin Time) bronchial - burn 18 of 133

19 -- C -- C-spine Cervical spine-range of motion 43 Cardiac troponin I (ctni) Cardiac troponin T (ctnt) 7 7 calcium Parathyroid function, low (hypoparathyroidism) 18 cardiomyopathy CARDIAC GENERAL Restrictive cardiomyopathy 8 Calcium, serum-high (hypercalcemia) Calcium, serum-low (hypocalcemia) 40 cardiopathy BLOOD/BONE MARROW Iron overload 4 calciuria Urinary electrolyte wasting (e.g., Fanconi's syndrome, renal tubular acidosis) 62 cardiopulmonary arrest CARDIAC GENERAL Cardiopulmonary arrest, cause unknown (non-fatal) 7 canalicular stenosis Eyelid dysfunction capillary leak syndrome VASCULAR Acute vascular leak syndrome 70 caries carotid Dental: teeth Intra-operative injury Carbon monoxide diffusion capacity (DLco) Carbon monoxide diffusion capacity (DL(co)) cardiac arrest See: cardiopulmonary arrest 56 VASCULAR cataract Vessel injury-artery -- Cataract 70 cardiac ischemia CARDIAC GENERAL Cardiac ischemia/infarction Cardiac troponin I (ctni) cardiac troponin CARDIAC GENERAL 7 7 catarrhal symptoms catheter Flu-like syndrome 68 C-spine - catheter 19 of 133

20 -- C -- cauterization CD4 Infection with unknown ANC -- Local complication -device/prosthesis-related Urinary frequency/urgency Urinary retention (including neurogenic bladder) Hemorrhage, GI -- BLOOD/BONE MARROW CD4 count Lymphopenia Infection with unknown ANC -- cellulitis Intra-operative injury -- Infection with unknown ANC -- Soft tissue necrosis cecitis cecum Opportunistic infection associated with >=Grade 2 Lymphopenia Typhlitis (cecal inflammation) Obstruction, GI -- Perforation, GI -- Stricture/stenosis (including anastomotic), GI -- Typhlitis (cecal inflammation) Ulcer, GI centripetal obesity Cushingoid appearance (e.g., moon face, buffalo hump, centripetal obesity, cutaneous striae) cerebral LYMPHATICS Edema: head and neck CNS cerebrovascular ischemia Leukoencephalopathy (radiographic findings) cerebrospinal fluid See: CSF Hemorrhage, GI cerebrovascular CARDIAC GENERAL cauterization - cerebrovascular 20 of 133

21 -- C -- cerumen CNS ischemia CNS cerebrovascular ischemia AUDITORY/EAR Otitis, external ear (non-infectious) cervical spine Cervical spine-range of motion Prolonged QTc interval Supraventricular and nodal arrhythmia -- Ventricular arrhythmia -- CARDIAC GENERAL Left ventricular diastolic dysfunction Left ventricular systolic dysfunction Myocarditis Restrictive cardiomyopathy Dyspnea (shortness of breath) cervix chelitis Infection with unknown ANC -- Intra-operative injury -- Chelitis 14 chills CONSTITUTIONAL SYMPTOMS Fever (in the absence of neutropenia, where neutropenia is defined as ANC <1.0 x 10e9/L) Rigors/chills Febrile neutropenia (fever of unknown origin without clinically or microbiologically documented infection)(anc <1.0 x 10e9/L, fever >=38.5 degrees C) Infection with unknown ANC chemoradiation chemosis CHF Rash: dermatitis associated with radiation -- Ocular surface disease CARDIAC ARRHYTHMIA Conduction abnormality/atrioventricular heart block choking Arachnoiditis/meningismus/radiculitis Cytokine release syndrome/acute infusion reaction Aspiration cholangitis HEPATOBILIARY/PANCREAS cerumen - cholangitis 21 of 133

22 -- C -- Cholecystitis cholecystitis HEPATOBILIARY/PANCREAS Cholecystitis chylothorax LYMPHATICS Chyle or lymph leakage Chylothorax Infection with unknown ANC -- Bilirubin (hyperbilirubinemia) 40 chylous ascites See: ascites cirrhosis HEPATOBILIARY/PANCREAS Liver dysfunction/failure (clinical) Viral hepatitis 34 cholesterol chondrosarcoma chorea Cholesterol, serum-high (hypercholestremia) Exostosis Extrapyramidal/involuntary movement/restlessness 43 ALT, SGPT (serum glutamic pyruvic transaminase) AST, SGOT(serum glutamic oxaloacetic transaminase) Sodium, serum-low (hyponatremia) claudication Intra-operative injury -- VASCULAR Vessel injury-artery -- Vessel injury-vein chromaturia Urine color change 62 clostridium difficile Colitis, infectious (e.g., Clostridium difficile) Chvostek's sign chyle Calcium, serum-low (hypocalcemia) LYMPHATICS Chyle or lymph leakage clotting COAGULATION INR (International Normalized Ratio of prothrombin time) PTT (Partial Thromboplastin Time) VASCULAR Phlebitis (including superficial thrombosis) cholecystitis - clotting 22 of 133

23 -- C -- Thrombosis/embolism (vascular access-related) Thrombosis/thrombus/embolism Neuropathy: cranial -- clumsy Intra-operative injury -- Ataxia (incoordination) CN III cluster headache CN Neuropathy: cranial -- Taste alteration (CN VII, IX) Intra-operative injury Infection with unknown ANC -- Neuropathy: cranial -- Intra-operative injury -- CN I Infection with unknown ANC -- Neuropathy: cranial -- Intra-operative injury -- CN IV Infection with unknown ANC -- Neuropathy: cranial -- Intra-operative injury -- CN II Infection with unknown ANC -- CN IX Infection with unknown ANC -- clumsy - CN IX 23 of 133

24 -- C -- Neuropathy: cranial -- Neuropathy: cranial -- Intra-operative injury -- Intra-operative injury -- CN V CN VIII Infection with unknown ANC -- Infection with unknown ANC -- Neuropathy: cranial -- Neuropathy: cranial -- Intra-operative injury -- Intra-operative injury -- CN VI CN X Infection with unknown ANC -- Infection with unknown ANC -- Neuropathy: cranial -- Neuropathy: cranial -- Intra-operative injury -- Intra-operative injury -- CN VII CN XI Infection with unknown ANC -- Infection with unknown ANC -- CN V - CN XI 24 of 133

25 -- C -- Platelets 4 Neuropathy: cranial -- COAGULATION CN XII Intra-operative injury -- Infection with unknown ANC -- Neuropathy: cranial -- DIC (disseminated intravascular coagulation) Fibrinogen INR (International Normalized Ratio of prothrombin time) PTT (Partial Thromboplastin Time) Thrombotic microangiopathy (e.g., thrombotic thrombocytopenic purpura [TTP] or hemolytic uremic syndrome [HUS]) HEPATOBILIARY/PANCREAS Liver dysfunction/failure (clinical) Viral hepatitis CNS Intra-operative injury -- CARDIAC GENERAL CNS ischemia COAGULATION DIC (disseminated intravascular coagulation) Thrombotic microangiopathy (e.g., thrombotic thrombocytopenic purpura [TTP] or hemolytic uremic syndrome [HUS]) Hemorrhage, CNS cochlear implant AUDITORY/EAR cognitive coitus Hearing: patients with/without baseline audiogram and enrolled in a monitoring program Cognitive disturbance Encephalopathy Speech impairment (e.g., dysphasia or aphasia) 2 51 CNS cerebrovascular ischemia CNS hemorrhage/bleeding CNS necrosis/cystic progression Speech impairment (e.g., dysphasia or aphasia) coagulation BLOOD/BONE MARROW 51 SEXUAL/REPRODUCTIVE FUNCTION Vaginal dryness Vaginal stenosis/length colectomy Necrosis, GI -- Obstruction, GI CN XII - colectomy 25 of 133

26 -- C -- colitis collagen collapsed lung colon Stricture/stenosis (including anastomotic), GI -- ALLERGY/IMMUNOLOGY Autoimmune reaction Colitis Colitis, infectious (e.g., Clostridium difficile) ALLERGY/IMMUNOLOGY Autoimmune reaction Pneumothorax Intra-operative injury -- Diarrhea Fistula, GI -- Ileus, GI (functional obstruction of bowel, i.e., neuroconstipation) Obstruction, GI -- Perforation, GI -- Stricture/stenosis (including anastomotic), GI -- Ulcer, GI -- Hemorrhage, GI coma Infection with unknown ANC -- Intra-operative injury -- COAGULATION Thrombotic microangiopathy (e.g., thrombotic thrombocytopenic purpura [TTP] or hemolytic uremic syndrome [HUS]) CONSTITUTIONAL SYMPTOMS Hypothermia Neuroendocrine: ADH secretion abnormality (e.g., SIADH or low ADH) Pancreatic endocrine: glucose intolerance Thyroid function, low (hypothyroidism) Hemorrhage, CNS HEPATOBILIARY/PANCREAS Liver dysfunction/failure (clinical) Viral hepatitis Arachnoiditis/meningismus/radiculitis Somnolence/depressed level of consciousness communicate Speech impairment (e.g., dysphasia or aphasia) Complete block See: atrioventricular rhythm colitis - concentration 26 of 133

27 -- C -- concentration Conduction abnormality See: atrioventricular rhythm conduit Confusion Irritability (children <3 years of age) Mood alteration -- Leak (including anastomotic), GI -- Intra-operative injury -- confluent Telangiectasia Mucositis/stomatitis (clinical exam) -- SEXUAL/REPRODUCTIVE FUNCTION Vaginal mucositis confusion Glucose, serum-high (hyperglycemia) Confusion Encephalopathy Memory impairment Somnolence/depressed level of consciousness Infection with unknown ANC -- Dry eye syndrome Eyelid dysfunction Ocular surface disease Intra-operative injury -- constipation Adrenal insufficiency Constipation Ileus, GI (functional obstruction of bowel, i.e., neuroconstipation) convulsions COAGULATION DIC (disseminated intravascular coagulation) Neuroendocrine: ADH secretion abnormality (e.g., SIADH or low ADH) Magnesium, serum-low (hypomagnesemia) Phosphate, serum-low (hypophosphatemia) congestive heart failure CARDIAC GENERAL Left ventricular systolic dysfunction conjunctiva 8 Seizure Coombs' BLOOD/BONE MARROW 51 concentration - Coombs' 27 of 133

28 -- C -- Hemolysis (e.g., immune hemolytic anemia, drug-related hemolysis) 4 Neuroendocrine: prolactin hormone secretion abnormality coordination corticotrophin cor pulmonale cording Pyramidal tract dysfunction (e.g., increased tone, hyperreflexia, positive Babinski, decreased fine motor coordination) CARDIAC GENERAL Right ventricular dysfunction (cor pulmonale) LYMPHATICS Phlebolymphatic cording cortisol coryza Neuroendocrine: ACTH deficiency Adrenal insufficiency ALLERGY/IMMUNOLOGY Allergic rhinitis (including sneezing, nasal stuffiness, postnasal drip) 1 cornea cosmesis Infection with unknown ANC -- cough Fibrosis-cosmesis CARDIAC GENERAL Left ventricular systolic dysfunction Right ventricular dysfunction (cor pulmonale) Dry eye syndrome Keratitis (corneal inflammation/corneal ulceration) coronary Intra-operative injury -- CARDIAC GENERAL Cardiac ischemia/infarction Cardiac troponin I (ctni) 7 7 Aspiration Atelectasis Cough Pneumothorax Pulmonary fibrosis (radiographic changes) Cytokine release syndrome/acute infusion reaction Flu-like syndrome corpus luteum CPAP coordination - CPAP 28 of 133

29 -- C -- CPK CPR See: cardiopulmonary arrest cramps Hypoxia CARDIAC GENERAL Cardiac ischemia/infarction Cardiac troponin I (ctni) CPK (creatine phosphokinase) Myositis (inflammation/damage of muscle) Parathyroid function, low (hypoparathyroidism) Abdominal pain or cramping Diarrhea Malabsorption Calcium, serum-low (hypocalcemia) cranial nerve Infection with unknown ANC -- Neuropathy: cranial creatine creatinine COAGULATION Cretinism cricothyroid crisis Intra-operative injury -- CPK (creatine phosphokinase) Thrombotic microangiopathy (e.g., thrombotic thrombocytopenic purpura [TTP] or hemolytic uremic syndrome [HUS]) Creatinine Glomerular filtration rate Uric acid, serum-high (hyperuricemia) Renal failure Urinary electrolyte wasting (e.g., Fanconi's syndrome, renal tubular acidosis) Tumor flare Tumor lysis syndrome Thyroid function, low (hypothyroidism) Laryngeal nerve dysfunction CARDIAC GENERAL Hypertension CPK - Crohn's diesease 29 of 133

30 -- C -- Crohn's diesease crown Colitis Dental: teeth development Dental: dentures or prosthesis Thrombotic microangiopathy (e.g., thrombotic thrombocytopenic purpura [TTP] or hemolytic uremic syndrome [HUS]) Hemorrhage, CNS CNS cerebrovascular ischemia Syncope (fainting) crying CSF ctni See: cardiac troponin ctnt See: cardiac troponin Cushingoid CONSTITUTIONAL SYMPTOMS CVA Irritability (children <3 years of age) Mood alteration -- Watery eye (epiphora, tearing) Arachnoiditis/meningismus/radiculitis Leak, cerebrospinal fluid (CSF) Weight gain Cushingoid appearance (e.g., moon face, buffalo hump, centripetal obesity, cutaneous striae) COAGULATION cyanosis cyst LYMPHATICS cystectomy cystitis Adult Respiratory Distress Syndrome (ARDS) Cough Dyspnea (shortness of breath) Obstruction/stenosis of airway -- Lymphocele Bladder spasms Incontinence, urinary Bladder spasms Cystitis cytogenetics BLOOD/BONE MARROW Myelodysplasia cytokine release syndrome Cytokine release syndrome/acute infusion reaction Crohn's diesease - cytokine release syndrome 30 of 133

31 -- D -- D-dimer COAGULATION DIC (disseminated intravascular coagulation) 10 Hemorrhage, CNS 30 DAT BLOOD/BONE MARROW Hemolysis (e.g., immune hemolytic anemia, drug-related hemolysis) deafness AUDITORY/EAR Hearing: patients with/without baseline audiogram and enrolled in a monitoring program Hearing: patients without baseline audiogram and not enrolled in a monitoring program CNS cerebrovascular ischemia Cognitive disturbance Confusion Hydrocephalus Glaucoma VASCULAR Peripheral arterial ischemia Visceral arterial ischemia (non-myocardial) death deformity DEATH GROWTH AND DEVELOPMENT Death not associated with CTCAE term -- debridement Burn Skin breakdown/decubitus ulcer Ulceration Bone growth: femoral head; slipped capital femoral epiphysis Muscular/skeletal hypoplasia SEXUAL/REPRODUCTIVE FUNCTION Breast nipple/areolar deformity Soft tissue necrosis dehiscence decubitus Wound complication, non-infectious 16 Skin breakdown/decubitus ulcer 16 dehydration CONSTITUTIONAL SYMPTOMS deep tendon reflexes deficit Calcium, serum-low (hypocalcemia) Magnesium, serum-high (hypermagnesemia) 40 Weight loss Dehydration Diarrhea Dysphagia (difficulty swallowing) Ileus, GI (functional obstruction of bowel, i.e., neuroconstipation) D-dimer - dehydration 31 of 133

32 -- D -- delirium delusions See: hallucinations dementia density Nausea Vomiting Acidosis (metabolic or respiratory) Calcium, serum-high (hypercalcemia) Confusion Confusion Induration/fibrosis (skin and subcutaneous tissue) LYMPHATICS Lymphedema-related fibrosis Fibrosis-deep connective tissue Osteoporosis Pulmonary fibrosis (radiographic changes) depression dermatitis dermatomyositis ALLERGY/IMMUNOLOGY despair Dental: teeth Infection with unknown ANC -- Mood alteration -- Rash/desquamation Rash: dermatitis associated with radiation -- Rash: hand-foot skin reaction Autoimmune reaction Mood alteration dental Dental: teeth development Dental: dentures or prosthesis Dental: periodontal disease desquamation AUDITORY/EAR Otitis, external ear (non-infectious) Photosensitivity Rash/desquamation Rash: acne/acneiform 2 delirium - desquamation of 133

33 -- D -- dialysis Rash: dermatitis associated with radiation -- COAGULATION Cytokine release syndrome/acute infusion reaction 68 Thrombotic microangiopathy (e.g., thrombotic thrombocytopenic purpura [TTP] or hemolytic uremic syndrome [HUS]) 10 development GROWTH AND DEVELOPMENT device Dental: teeth development Bone age (alteration in bone age) Puberty (delayed) Cognitive disturbance CARDIAC ARRHYTHMIA Conduction abnormality/atrioventricular heart block -- Supraventricular and nodal arrhythmia -- Ventricular arrhythmia -- CARDIAC GENERAL Glomerular filtration rate Magnesium, serum-high (hypermagnesemia) Renal failure diaphoresis CONSTITUTIONAL SYMPTOMS Sweating (diaphoresis) Cushingoid appearance (e.g., moon face, buffalo hump, centripetal obesity, cutaneous striae) Hot flashes/flushes Glucose, serum-high (hyperglycemia) Glucose, serum-low (hypoglycemia) Left ventricular diastolic dysfunction Left ventricular systolic dysfunction Restrictive cardiomyopathy Right ventricular dysfunction (cor pulmonale) Cytokine release syndrome/acute infusion reaction diaphragmatic plication 68 Local complication -device/prosthesis-related 44 Phrenic nerve dysfunction diabetes Acidosis (metabolic or respiratory) Glucose, serum-high (hyperglycemia) Glucose, serum-low (hypoglycemia) Potassium, serum-low (hypokalemia) Cataract diarrhea Adrenal insufficiency Dehydration Diarrhea Fistula, GI -- Malabsorption development - diarrhea 33 of 133

34 -- D -- diastolic DIC Obstruction, GI -- Stricture/stenosis (including anastomotic), GI -- CARDIAC GENERAL Hypertension Left ventricular diastolic dysfunction COAGULATION DIC (disseminated intravascular coagulation) Fibrinogen INR (International Normalized Ratio of prothrombin time) PTT (Partial Thromboplastin Time) difficile See: clostridium difficile Colitis, infectious (e.g., Clostridium difficile) diplopia Obstruction/stenosis of airway -- Obstruction, GU -- Stricture/stenosis (including anastomotic), GU -- Ophthalmoplegia/diplopia (double vision) disc See: optic disc discharge AUDITORY/EAR Otitis, external ear (non-infectious) Otitis, middle ear (non-infectious) SEXUAL/REPRODUCTIVE FUNCTION Vaginal discharge (non-infectious) diffusion Carbon monoxide diffusion capacity (DL(co)) digestion HEPATOBILIARY/PANCREAS Pancreatitis Lipase discoloration Petechiae/purpura (hemorrhage/bleeding into skin or mucosa) LYMPHATICS Dermal change lymphedema, phlebolymphedema discouragement Mood alteration dilation Dysphagia (difficulty swallowing) Obstruction, GI -- Stricture/stenosis (including anastomotic), GI disease DEATH Death not associated with CTCAE term -- Ocular surface disease diastolic - disequilibrium 34 of 133

35 -- D -- disequilibrium disfigurement disorder Dizziness Rash: acne/acneiform Fibrosis-cosmesis ALLERGY/IMMUNOLOGY Autoimmune reaction 43 1 Eyelid dysfunction Optic disc edema Scleral necrosis/melt SEXUAL/REPRODUCTIVE FUNCTION Ejaculatory dysfunction disorientation Confusion disseminated See: DIC BLOOD/BONE MARROW Splenic function Nail changes Dental: teeth development Dental: periodontal disease Dental: teeth Salivary gland changes/saliva Joint-function Muscle weakness, generalized or specific area (not due to neuropathy) -- Cognitive disturbance Extrapyramidal/involuntary movement/restlessness Neuropathy: cranial -- Seizure Speech impairment (e.g., dysphasia or aphasia) distention diuresis Ascites (non-malignant) Distension/bloating, abdominal Flatulence Obstruction, GI -- Bladder spasms Obstruction, GU -- Urinary frequency/urgency Urinary retention (including neurogenic bladder) Neuroendocrine: ADH secretion abnormality (e.g., SIADH or low ADH) dizziness CARDIAC ARRHYTHMIA Conduction abnormality/atrioventricular heart block -- Prolonged QTc interval Supraventricular and nodal arrhythmia -- Vasovagal episode disequilibrium - dizziness of 133

36 -- D -- CARDIAC GENERAL Hypotension 8 Cytokine release syndrome/acute infusion reaction 68 Dizziness Encephalopathy Syncope (fainting) 51 dry eye syndrome Dry eye syndrome DKA DLco DM dribbling Cytokine release syndrome/acute infusion reaction Glucose, serum-high (hyperglycemia) Carbon monoxide diffusion capacity (DL(co)) Glucose, serum-high (hyperglycemia) Glucose, serum-low (hypoglycemia) Incontinence, urinary Urinary retention (including neurogenic bladder) drowsiness Sodium, serum-low (hyponatremia) Somnolence/depressed level of consciousness drug fever ALLERGY/IMMUNOLOGY Allergic reaction/hypersensitivity (including drug fever) duodenum dura Fistula, GI -- Necrosis, GI -- Obstruction, GI -- Perforation, GI -- Stricture/stenosis (including anastomotic), GI -- Ulcer, GI -- Hemorrhage, GI -- Infection with unknown ANC -- Intra-operative injury -- Arachnoiditis/meningismus/radiculitis DVT See: thrombosis dwarfism Neuroendocrine: DKA - dwarfism of 133

37 -- D -- growth hormone secretion abnormality Neuropathy: cranial -- dysarthria Laryngeal nerve dysfunction Speech impairment (e.g., dysphasia or aphasia) 51 dysphasia Neuropathy: cranial -- Speech impairment (e.g., dysphasia or aphasia) 51 Voice changes/dysarthria (e.g., hoarseness, loss or alteration in voice, laryngitis) dysgeusia See: CN IX, CN VII Salivary gland changes/saliva Taste alteration (dysgeusia) dysmenorrhea SEXUAL/REPRODUCTIVE FUNCTION Dysmenorrhea dyspareunia SEXUAL/REPRODUCTIVE FUNCTION Vaginal dryness Vaginal mucositis dyspnea ALLERGY/IMMUNOLOGY dysuria Allergic reaction/hypersensitivity (including drug fever) Atelectasis Dyspnea (shortness of breath) Cytokine release syndrome/acute infusion reaction Cystitis dyspepsia Heartburn/dyspepsia 22 dysphagia Dysphagia (difficulty swallowing) Esophagitis Obstruction, GI -- Salivary gland changes/saliva Stricture/stenosis (including anastomotic), GI dysarthria - dysuria 37 of 133

38 -- E -- ear See: CN IX AUDITORY/EAR earache Hearing: patients with/without baseline audiogram and enrolled in a monitoring program Hearing: patients without baseline audiogram and not enrolled in a monitoring program Otitis, external ear (non-infectious) Otitis, middle ear (non-infectious) Tinnitus Infection with unknown ANC -- Neuropathy: cranial -- Intra-operative injury CARDIAC ARRHYTHMIA CARDIAC GENERAL ectropion eczema Conduction abnormality/atrioventricular heart block -- Prolonged QTc interval Supraventricular and nodal arrhythmia -- Vasovagal episode Ventricular arrhythmia -- Cardiac ischemia/infarction Cardiopulmonary arrest, cause unknown (non-fatal) Myocarditis Pericarditis Restrictive cardiomyopathy Potassium, serum-high (hyperkalemia) Potassium, serum-low (hypokalemia) Eyelid dysfunction ALLERGY/IMMUNOLOGY Allergic reaction/hypersensitivity (including drug fever) Dry skin ecchymosis COAGULATION ECG DIC (disseminated intravascular coagulation) Bruising (in absence of Grade 3 or 4 thrombocytopenia) Cushingoid appearance (e.g., moon face, buffalo hump, centripetal obesity, cutaneous striae) edema ALLERGY/IMMUNOLOGY Allergic reaction/hypersensitivity (including drug fever) Serum sickness AUDITORY/EAR Otitis, external ear (non-infectious) CARDIAC GENERAL Left ventricular systolic dysfunction ear - edema 38 of 133

39 -- E -- CONSTITUTIONAL SYMPTOMS Hypothermia Weight gain Rash: dermatitis associated with radiation -- Rash: hand-foot skin reaction VASCULAR EEG Acute vascular leak syndrome Leukoencephalopathy (radiographic findings) Neuroendocrine: ADH secretion abnormality (e.g., SIADH or low ADH) Thyroid function, low (hypothyroidism) Ascites (non-malignant) LYMPHATICS Dermal change lymphedema, phlebolymphedema Edema: head and neck Edema: limb Edema: trunk/genital Edema: viscera Lymphedema-related fibrosis Proteinuria EF CARDIAC GENERAL effusion CARDIAC GENERAL EIOP Left ventricular systolic dysfunction Myocarditis Pericardial effusion (non-malignant) Joint-effusion Pleural effusion (non-malignant) "Retinoic acid syndrome" Glaucoma Optic disc edema Edema, larynx Nasal cavity/paranasal sinus reactions Voice changes/dysarthria (e.g., hoarseness, loss or alteration in voice, laryngitis) Renal failure ejaculation SEXUAL/REPRODUCTIVE FUNCTION Ejaculatory dysfunction ejection See: EF EKG See: ECG 64 EEG - electrocardiogram 39 of 133

40 -- E -- electrocardiogram See: ECG Mood alteration electrolyte embolism emesis emotion Dehydration Bicarbonate, serum-low Calcium, serum-high (hypercalcemia) Calcium, serum-low (hypocalcemia) Potassium, serum-high (hyperkalemia) Potassium, serum-low (hypokalemia) Sodium, serum-high (hypernatremia) Sodium, serum-low (hyponatremia) Urinary electrolyte wasting (e.g., Fanconi's syndrome, renal tubular acidosis) Tumor flare COAGULATION Thrombotic microangiopathy (e.g., thrombotic thrombocytopenic purpura [TTP] or hemolytic uremic syndrome [HUS]) Pulmonary embolism VASCULAR Thrombosis/embolism (vascular access-related) Thrombosis/thrombus/embolism Vomiting empyema Infection with unknown ANC -- encephalitis Infection with unknown ANC -- encephalopathy COAGULATION Thrombotic microangiopathy (e.g., thrombotic thrombocytopenic purpura [TTP] or hemolytic uremic syndrome [HUS]) HEPATOBILIARY/PANCREAS Liver dysfunction/failure (clinical) Viral hepatitis Encephalopathy Leukoencephalopathy (radiographic findings) endocarditis CARDIAC GENERAL Valvular heart disease electrocardiogram - endocarditis 40 of 133

41 -- E -- enophthalmos Infection with unknown ANC -- endocrinopathy BLOOD/BONE MARROW Iron overload 4 enteritis Proptosis/enophthalmos Enteritis (inflammation of the small bowel) Necrosis, GI endoscopy Esophagitis Gastritis (including bile reflux gastritis) Hemorrhoids Leak (including anastomotic), GI -- Necrosis, GI -- Ulcer, GI -- Hemorrhage, GI -- Hemorrhage, GU -- Hemorrhage, pulmonary/upper respiratory -- Hemorrhage/bleeding associated with surgery, intraoperative or postoperative HEPATOBILIARY/PANCREAS Cholecystitis Fistula, pulmonary/upper respiratory -- Obstruction/stenosis of airway -- Leak (including anastomotic), GU -- Obstruction, GU -- Stricture/stenosis (including anastomotic), GU entropion enucleation enuresis enzymes Eyelid dysfunction Glaucoma Scleral necrosis/melt Urinary frequency/urgency Malabsorption HEPATOBILIARY/PANCREAS Pancreas, exocrine enzyme deficiency Pancreatitis ALT, SGPT (serum glutamic pyruvic transaminase) AST, SGOT(serum glutamic oxaloacetic transaminase) GGT (gamma-glutamyl transpeptidase) Lipase enema Constipation 19 epidermal necrolysis Rash: erythema multiforme (e.g., Stevens-Johnson endocrinopathy - epidermal necrolysis of 133

42 -- E -- epilation epilepsy See: seizure epiphora syndrome, toxic epidermal necrolysis) Eyelid dysfunction Watery eye (epiphora, tearing) 54 Photosensitivity Rash/desquamation Rash: dermatitis associated with radiation -- Rash: erythema multiforme (e.g., Stevens-Johnson syndrome, toxic epidermal necrolysis) Rash: hand-foot skin reaction Mucositis/stomatitis (clinical exam) -- Mucositis/stomatitis (functional/symptomatic) -- Arthritis (non-septic) epiphysiodesis GROWTH AND DEVELOPMENT Bone growth: limb length discrepancy 29 Eyelid dysfunction SEXUAL/REPRODUCTIVE FUNCTION Vaginal mucositis 65 epiphysis GROWTH AND DEVELOPMENT Bone growth: femoral head; slipped capital femoral epiphysis epistaxis Hemorrhage, pulmonary/upper respiratory -- erections SEXUAL/REPRODUCTIVE FUNCTION Erectile dysfunction Libido erythema AUDITORY/EAR Otitis, external ear (non-infectious) Injection site reaction/extravasation changes VASCULAR Phlebitis (including superficial thrombosis) erythroderma Rash/desquamation Rash: erythema multiforme (e.g., Stevens-Johnson syndrome, toxic epidermal necrolysis) Rash: hand-foot skin reaction Infection with unknown ANC -- Arthritis (non-septic) VASCULAR Phlebitis (including superficial thrombosis) epilation - esophageal varices 42 of 133

43 -- E -- esophageal varices Hemorrhage, GI -- esophagitis Dysphagia (difficulty swallowing) Esophagitis Heartburn/dyspepsia Mucositis/stomatitis (functional/symptomatic) estrogen Neuroendocrine: prolactin hormone secretion abnormality SEXUAL/REPRODUCTIVE FUNCTION euphoria Gynecomastia Mood alteration esophagus Fistula, GI -- Leak (including anastomotic), GI -- Mucositis/stomatitis (clinical exam) -- Mucositis/stomatitis (functional/symptomatic) -- Necrosis, GI -- Obstruction, GI -- Perforation, GI -- Stricture/stenosis (including anastomotic), GI -- Ulcer, GI -- Hemorrhage, GI -- Infection with unknown ANC evacuation Constipation Hematoma evisceration Wound complication, non-infectious Infection with unknown ANC -- excitability Calcium, serum-high (hypercalcemia) Irritability (children <3 years of age) Fistula, pulmonary/upper respiratory -- Intra-operative injury exfoliative See: dermatitis exocrine esophageal varices - exocrine 43 of 133

44 -- E -- HEPATOBILIARY/PANCREAS Pancreas, exocrine enzyme deficiency exostosis Exostosis expressive dysphasia See: dysphasia eye See: CN VI, CN IV Infection with unknown ANC -- Neuropathy: cranial -- external See: ear extraocular See: CN III Muscle weakness, generalized or specific area (not due to neuropathy) -- extrapyramidal/involuntary movement Extrapyramidal/involuntary movement/restlessness extrasystoles CARDIAC ARRHYTHMIA Conduction abnormality/atrioventricular heart block -- Supraventricular and nodal arrhythmia -- Ventricular arrhythmia Dry eye syndrome Eyelid dysfunction Scleral necrosis/melt Watery eye (epiphora, tearing) Intra-operative injury -- eyelid See: CN III Eyelid dysfunction extravasation Injection site reaction/extravasation changes 14 Hematoma 30 Cytokine release syndrome/acute infusion reaction 68 exostosis - eyelid 44 of 133

45 -- F -- face facial nerve See: CN VII fainting falling Cushingoid appearance (e.g., moon face, buffalo hump, centripetal obesity, cutaneous striae) Masculinization of female LYMPHATICS Edema: head and neck Muscle weakness, generalized or specific area (not due to neuropathy) -- Neuropathy: cranial -- Intra-operative injury -- CARDIAC ARRHYTHMIA Syncope Vasovagal episode Adrenal insufficiency Glucose, serum-low (hypoglycemia) Dizziness Syncope (fainting) fallopian tube Fanconi's syndrome fascia Ataxia (incoordination) Hemorrhage, GU -- Infection with unknown ANC -- Leak (including anastomotic), GU -- Obstruction, GU -- Perforation, GU -- Stricture/stenosis (including anastomotic), GU -- Intra-operative injury -- Phosphate, serum-low (hypophosphatemia) Urinary electrolyte wasting (e.g., Fanconi's syndrome, renal tubular acidosis) Wound complication, non-infectious Infection with unknown ANC face - fascia 45 of 133

46 -- F -- Intra-operative injury -- Mood alteration fascitis See: fascia fatigue CONSTITUTIONAL SYMPTOMS Fatigue (asthenia, lethargy, malaise) Muscle weakness, generalized or specific area (not due to neuropathy) -- Cytokine release syndrome/acute infusion reaction feminization femoral head GROWTH AND DEVELOPMENT fertility Feminization of male Bone growth: femoral head; slipped capital femoral epiphysis SEXUAL/REPRODUCTIVE FUNCTION Infertility/sterility fear Mood alteration FEV1 FEV(1) 57 febrile neutropenia BLOOD/BONE MARROW feces feelings Neutrophils/granulocytes (ANC/AGC) Febrile neutropenia (fever of unknown origin without clinically or microbiologically documented infection)(anc <1.0 x 10e9/L, fever >=38.5 degrees C) Infection with unknown ANC -- Constipation Diarrhea Incontinence, anal fever ALLERGY/IMMUNOLOGY Allergic reaction/hypersensitivity (including drug fever) Autoimmune reaction Serum sickness CONSTITUTIONAL SYMPTOMS Fever (in the absence of neutropenia, where neutropenia is defined as ANC <1.0 x 10e9/L) Rigors/chills Colitis Enteritis (inflammation of the small bowel) Typhlitis (cecal inflammation) HEPATOBILIARY/PANCREAS Pancreatitis Febrile neutropenia (fever of unknown origin without fascitis - fever 46 of 133

47 -- F -- clinically or microbiologically documented infection)(anc <1.0 x 10e9/L, fever >=38.5 degrees C) Infection with unknown ANC -- Arachnoiditis/meningismus/radiculitis "Retinoic acid syndrome" Cytokine release syndrome/acute infusion reaction Flu-like syndrome fibrillation CARDIAC ARRHYTHMIA Supraventricular and nodal arrhythmia -- Ventricular arrhythmia -- CONSTITUTIONAL SYMPTOMS Hypothermia fibrosis Petechiae/purpura (hemorrhage/bleeding into skin or mucosa) Atrophy, subcutaneous fat Induration/fibrosis (skin and subcutaneous tissue) Viral hepatitis LYMPHATICS Lymphedema-related fibrosis Fibrosis-cosmesis Fibrosis-deep connective tissue Pulmonary fibrosis (radiographic changes) First degree block See: atrioventricular rhythm fibrin COAGULATION DIC (disseminated intravascular coagulation) 10 fissure Proctitis 26 fibrinogen COAGULATION Fibrinogen Hematoma Hemorrhage, CNS Hemorrhage, GI -- Hemorrhage, GU -- Hemorrhage, pulmonary/upper respiratory -- Hemorrhage/bleeding associated with surgery, intraoperative or postoperative fistula Fistula, GI -- Prolapse of stoma, GI Stricture/stenosis (including anastomotic), GI -- Fistula, pulmonary/upper respiratory -- Fistula, GU -- Prolapse of stoma, GU fibrillation - fistula of 133

48 -- F -- fixation Intra-operative injury -- Induration/fibrosis (skin and subcutaneous tissue) GROWTH AND DEVELOPMENT Bone growth: femoral head; slipped capital femoral epiphysis Fibrosis-deep connective tissue flexion floaters Bone: spine-scoliosis Cervical spine-range of motion Lumbar spine-range of motion Vision-flashing lights/floaters flu-like See: syndrome flank fluids CARDIAC GENERAL Hypotension 8 flap flare Skin breakdown/decubitus ulcer Ulceration Wound complication, non-infectious Soft tissue necrosis -- Tumor flare Anorexia Ascites (non-malignant) Dehydration Dysphagia (difficulty swallowing) Esophagitis Fistula, GI -- Gastritis (including bile reflux gastritis) Nausea Obstruction, GI -- Stricture/stenosis (including anastomotic), GI -- Ulcer, GI flashes Hot flashes/flushes Vision-flashing lights/floaters flatulence Flatulence VASCULAR flushing Leak, cerebrospinal fluid (CSF) "Retinoic acid syndrome" Acute vascular leak syndrome fixation - flushing of 133

49 -- F -- ALLERGY/IMMUNOLOGY Allergic reaction/hypersensitivity (including drug fever) 1 forgetful Memory impairment 49 CONSTITUTIONAL SYMPTOMS flutter CARDIAC ARRHYTHMIA focal Sweating (diaphoresis) Flushing Hot flashes/flushes Supraventricular and nodal arrhythmia -- Ventricular arrhythmia -- Telangiectasia Leukoencephalopathy (radiographic findings) Seizure Folstein Mini-Mental Exam Mental status forced expiratory volume See: FEV1 foreign body Infection with unknown ANC fracture Neuroendocrine: gonadotropin secretion abnormality Dental: teeth Fracture Osteoporosis frequency Cystitis Urinary frequency/urgency function ALLERGY/IMMUNOLOGY Autoimmune reaction BLOOD/BONE MARROW Splenic function Parathyroid function, low (hypoparathyroidism) Thyroid function, high (hyperthyroidism, thyrotoxicosis) Thyroid function, low (hypothyroidism) Mucositis/stomatitis (functional/symptomatic) -- Splenic function Arthritis (non-septic) Bone: spine-scoliosis Extremity-lower (gait/walking) flutter - function 49 of 133

50 -- F -- fuse Extremity-upper (function) Joint-function Memory impairment Neuropathy: motor Neuropathy: sensory SEXUAL/REPRODUCTIVE FUNCTION Breast function/lactation Erectile dysfunction Vaginal stenosis/length Cervical spine-range of motion Lumbar spine-range of motion fuse - fuse of 133

51 -- G -- gait GROWTH AND DEVELOPMENT Bone growth: limb length discrepancy Bone growth: spine kyphosis/lordosis Extremity-lower (gait/walking) Ataxia (incoordination) Dizziness galactorrhea Feminization of male Neuroendocrine: prolactin hormone secretion abnormality SEXUAL/REPRODUCTIVE FUNCTION Gynecomastia gallbladder Fistula, GI -- Necrosis, GI -- Obstruction, GI -- Perforation, GI -- HEPATOBILIARY/PANCREAS Cholecystitis Infection with unknown ANC gallstones HEPATOBILIARY/PANCREAS gamma-glutamyl See: GGT gas See: flatulence gastrectomy gastric Intra-operative injury -- Cholecystitis Gastritis (including bile reflux gastritis) Intra-operative injury -- Gastritis (including bile reflux gastritis) Ileus, GI (functional obstruction of bowel, i.e., neuroconstipation) Necrosis, GI -- Perforation, GI -- Stricture/stenosis (including anastomotic), GI -- Ulcer, GI -- Hemorrhage, GI -- gastritis See: gastric gastroesophageal reflux Esophagitis gait - gastroesophageal reflux 51 of 133

52 -- G -- Gastritis (including bile reflux gastritis) Heartburn/dyspepsia gender-appropriate CARDIAC GENERAL Hypertension GROWTH AND DEVELOPMENT Short stature Infection with unknown ANC -- Intra-operative injury -- genital SEXUAL/REPRODUCTIVE FUNCTION GFR Infection with unknown ANC -- Fistula, GU -- Erectile dysfunction Glomerular filtration rate Glasgow coma scale Somnolence/depressed level of consciousness glaucoma Glaucoma glomerular filtration See: GFR Glomerular filtration rate glossopharyngeal See: CN IX 51 GGT gingiva GGT (gamma-glutamyl transpeptidase) Dental: periodontal disease Necrosis, GI glucose Cushingoid appearance (e.g., moon face, buffalo hump, centripetal obesity, cutaneous striae) Neuroendocrine: growth hormone secretion abnormality Pancreatic endocrine: glucose intolerance Glucose, serum-high (hyperglycemia) Glucose, serum-low (hypoglycemia) 18 gender-appropriate - glyceride of 133

53 -- G -- glyceride glycosuria gonadotropin graft Cholesterol, serum-high (hypercholestremia) Pancreatic endocrine: glucose intolerance Glucose, serum-high (hyperglycemia) Urinary electrolyte wasting (e.g., Fanconi's syndrome, renal tubular acidosis) Neuroendocrine: gonadotropin secretion abnormality Skin breakdown/decubitus ulcer Ulceration Wound complication, non-infectious Infection with unknown ANC growth GROWTH AND DEVELOPMENT guiac gums Neuroendocrine: growth hormone secretion abnormality Bone growth: limb length discrepancy Bone growth: spine kyphosis/lordosis Bone growth: femoral head; slipped capital femoral epiphysis Growth velocity (reduction in growth velocity) Short stature Hemorrhage, GI -- Mucositis/stomatitis (clinical exam) -- Mucositis/stomatitis (functional/symptomatic) -- Infection with unknown ANC Soft tissue necrosis -- grand mall See: seizure granulocytes See: ANC 46 gustatory GVHD Taste alteration (dysgeusia) Rash/desquamation 27 glyceride - GVHD 53 of 133

54 -- G -- Diarrhea Mucositis/stomatitis (functional/symptomatic) -- HEPATOBILIARY/PANCREAS Liver dysfunction/failure (clinical) gynecomastia SEXUAL/REPRODUCTIVE FUNCTION Gynecomastia gynecomastia - gynecomastia 54 of 133

55 -- H -- hair Hair loss/alopecia (scalp or body) hallucinations Confusion Encephalopathy Psychosis (hallucinations/delusions) 14 hearing See: CN VIII AUDITORY/EAR Hearing: patients with/without baseline audiogram and enrolled in a monitoring program Hearing: patients without baseline audiogram and not enrolled in a monitoring program Neuropathy: cranial hand-foot Rash: hand-foot skin reaction heart CARDIAC ARRHYTHMIA Conduction abnormality/atrioventricular heart block -- 5 haptoglobin ALLERGY/IMMUNOLOGY Autoimmune reaction BLOOD/BONE MARROW Haptoglobin Hemoglobin Hemolysis (e.g., immune hemolytic anemia, drug-related hemolysis) Bilirubin (hyperbilirubinemia) hardware See: device headache Leak, cerebrospinal fluid (CSF) CARDIAC GENERAL Cardiac ischemia/infarction Cardiac troponin I (ctni) Left ventricular diastolic dysfunction Left ventricular systolic dysfunction Myocarditis Restrictive cardiomyopathy Right ventricular dysfunction (cor pulmonale) Valvular heart disease Infection with unknown ANC -- Triglyceride, serum-high (hypertriglyceridemia) Intra-operative injury "Retinoic acid syndrome" Cytokine release syndrome/acute infusion reaction Flu-like syndrome heartburn See: dyspepsia height hair - height of 133

56 -- H -- GROWTH AND DEVELOPMENT Short stature 29 Colitis 19 Osteoporosis 46 Hemorrhage, GI helicobacter pylorii hematoma Ulcer, GI Hematoma 30 helmet cells hematuria ALLERGY/IMMUNOLOGY Autoimmune reaction 1 Hemorrhage, GU -- BLOOD/BONE MARROW Haptoglobin Hemoglobin Hemolysis (e.g., immune hemolytic anemia, drug-related hemolysis) COAGULATION Thrombotic microangiopathy (e.g., thrombotic thrombocytopenic purpura [TTP] or hemolytic uremic syndrome [HUS]) Bilirubin (hyperbilirubinemia) hematemesis COAGULATION DIC (disseminated intravascular coagulation) Cystitis Urine color change hemodialysis Renal failure hemoglobin ALLERGY/IMMUNOLOGY Autoimmune reaction BLOOD/BONE MARROW Hemoglobin Hemolysis (e.g., immune hemolytic anemia, drug-related hemolysis) Gastritis (including bile reflux gastritis) 22 Hemoglobinuria Hemorrhage, GI hemoglobinuria hematochezia Hemoglobinuria CONSTITUTIONAL SYMPTOMS Weight loss 12 hemolysis ALLERGY/IMMUNOLOGY helicobacter pylorii - hemolysis 56 of 133

57 -- H -- Autoimmune reaction BLOOD/BONE MARROW Hemolysis (e.g., immune hemolytic anemia, drug-related hemolysis) Phosphate, serum-low (hypophosphatemia) hemolytic anemia BLOOD/BONE MARROW Hemolysis (e.g., immune hemolytic anemia, drug-related hemolysis) COAGULATION Thrombotic microangiopathy (e.g., thrombotic thrombocytopenic purpura [TTP] or hemolytic uremic syndrome [HUS]) hemolytic uremic syndrome See: HUS hemoptysis Hemorrhage, pulmonary/upper respiratory COAGULATION DIC (disseminated intravascular coagulation) INR (International Normalized Ratio of prothrombin time) Thrombotic microangiopathy (e.g., thrombotic thrombocytopenic purpura [TTP] or hemolytic uremic syndrome [HUS]) Hemorrhage, CNS Hemorrhage, GI -- Hemorrhage, GU -- Hemorrhage, pulmonary/upper respiratory -- Hemorrhage/bleeding associated with surgery, intraoperative or postoperative hepatic coma HEPATOBILIARY/PANCREAS Liver dysfunction/failure (clinical) Alkaline phosphatase ALT, SGPT (serum glutamic pyruvic transaminase) AST, SGOT(serum glutamic oxaloacetic transaminase) GGT (gamma-glutamyl transpeptidase) hemorrhage See: bleeding hepatic enzymes See: AST, ALT hemorrhoids Hemorrhoids Proctitis Hemorrhage, GI -- hemostasis hepatitis HEPATOBILIARY/PANCREAS Liver dysfunction/failure (clinical) Viral hepatitis Bilirubin (hyperbilirubinemia) hepatomegaly HEPATOBILIARY/PANCREAS hemolytic anemia - hepatomegaly 57 of 133

58 -- H -- Liver dysfunction/failure (clinical) 34 Hohman's sign See: thrombosis VASCULAR hernia hesitancy hiccoughs hirsutism See: masculinization of female hives Portal vein flow Wound complication, non-infectious Urinary retention (including neurogenic bladder) Hiccoughs (hiccups, singultus) ALLERGY/IMMUNOLOGY Allergic reaction/hypersensitivity (including drug fever) Rash: erythema multiforme (e.g., Stevens-Johnson syndrome, toxic epidermal necrolysis) Urticaria (hives, welts, wheals) hormone Neuroendocrine: ACTH deficiency Neuroendocrine: ADH secretion abnormality (e.g., SIADH or low ADH) Neuroendocrine: growth hormone secretion abnormality Neuroendocrine: prolactin hormone secretion abnormality Thyroid function, high (hyperthyroidism, thyrotoxicosis) Thyroid function, low (hypothyroidism) GROWTH AND DEVELOPMENT Puberty (delayed) Short stature hot flashes See: flushing Howell-Jolly bodies BLOOD/BONE MARROW Splenic function hump See: Cushingoid Cytokine release syndrome/acute infusion reaction hoarseness Speech impairment (e.g., dysphasia or aphasia) Voice changes/dysarthria (e.g., hoarseness, loss or alteration in voice, laryngitis) hunger HUS Glucose, serum-low (hypoglycemia) COAGULATION Thrombotic microangiopathy (e.g., thrombotic thrombocytopenic purpura [TTP] or hemolytic uremic syndrome [HUS]) 10 hydrocephalus hernia - hydrocephalus 58 of 133

59 -- H -- hyperchloremic Hydrocephalus Acidosis (metabolic or respiratory) 40 hydronephrosis hypercholestremia Obstruction, GU -- Stricture/stenosis (including anastomotic), GU -- hyperammonemia Uric acid, serum-high (hyperuricemia) hyperbaric oxygen Skin breakdown/decubitus ulcer Ulceration Wound complication, non-infectious Cholesterol, serum-high (hypercholestremia) hyperemesis Nausea hyperglycemia Cushingoid appearance (e.g., moon face, buffalo hump, centripetal obesity, cutaneous striae) HEPATOBILIARY/PANCREAS Pancreatitis Osteonecrosis (avascular necrosis) Soft tissue necrosis -- CNS necrosis/cystic progression hyperbilirubinemia Bilirubin (hyperbilirubinemia) hypercalcemia Glucose, serum-high (hyperglycemia) hyperintensities Leukoencephalopathy (radiographic findings) hyperkalemia Potassium, serum-high (hyperkalemia) Uric acid, serum-high (hyperuricemia) Calcium, serum-high (hypercalcemia) Tumor lysis syndrome 69 Tumor flare 69 hyperkinetic hypercapneic Cognitive disturbance Acidosis (metabolic or respiratory) 40 hyperlipoproteinemia hydronephrosis - hyperlipoproteinemia 59 of 133

60 -- H -- Triglyceride, serum-high (hypertriglyceridemia) hypermagnesemia Magnesium, serum-high (hypermagnesemia) 42 Injection site reaction/extravasation changes Rash/desquamation Urticaria (hives, welts, wheals) Cytokine release syndrome/acute infusion reaction hypermetabolic Thyroid function, high (hyperthyroidism, thyrotoxicosis) hypernatremia Sodium, serum-high (hypernatremia) hyperosmolar Pancreatic endocrine: glucose intolerance hyperpigmentation Hyperpigmentation Cushingoid appearance (e.g., moon face, buffalo hump, centripetal obesity, cutaneous striae) hyperreflexia Arachnoiditis/meningismus/radiculitis Pyramidal tract dysfunction (e.g., increased tone, hyperreflexia, positive Babinski, decreased fine motor coordination) hypersensitivity ALLERGY/IMMUNOLOGY Allergic reaction/hypersensitivity (including drug fever) hypertension CARDIAC GENERAL Hypertension Pulmonary hypertension Cushingoid appearance (e.g., moon face, buffalo hump, centripetal obesity, cutaneous striae) Sodium, serum-high (hypernatremia) Hydrocephalus Cytokine release syndrome/acute infusion reaction VASCULAR Portal vein flow hypertensive crisis See: hypertension hyperthyroidism Thyroid function, high (hyperthyroidism, thyrotoxicosis) hypertriglyceridemia Triglyceride, serum-high (hypertriglyceridemia) hypertrophy hypermagnesemia - hypertrophy 60 of 133

61 -- H -- Exostosis 43 Cushingoid appearance (e.g., moon face, buffalo hump, centripetal obesity, cutaneous striae) hyperuricemia Uric acid, serum-high (hyperuricemia) 42 hypogeusia Taste alteration (dysgeusia) 27 hypnesthesia Brachial plexopathy Somnolence/depressed level of consciousness hypoalbuminemia Viral hepatitis Albumin, serum-low (hypoalbuminemia) Calcium, serum-low (hypocalcemia) hypocalcemia Calcium, serum-low (hypocalcemia) Urinary electrolyte wasting (e.g., Fanconi's syndrome, renal tubular acidosis) hypocellular BLOOD/BONE MARROW Bone marrow cellularity hypochloremic Alkalosis (metabolic or respiratory) hypocortisolism hypoglossal See: CN XII hypoglycemia Glucose, serum-low (hypoglycemia) hypokalemia Cushingoid appearance (e.g., moon face, buffalo hump, centripetal obesity, cutaneous striae) Alkalosis (metabolic or respiratory) Potassium, serum-low (hypokalemia) hypomagnesemia Magnesium, serum-low (hypomagnesemia) hyponatremia Neuroendocrine: ADH secretion abnormality (e.g., SIADH or low ADH) Sodium, serum-low (hyponatremia) hypoparathyroidism Parathyroid function, low (hypoparathyroidism) hyperuricemia - hypophosphatemia 61 of 133

62 -- H -- hypophosphatemia CARDIAC GENERAL Phosphate, serum-low (hypophosphatemia) Hypotension 8 CONSTITUTIONAL SYMPTOMS Urinary electrolyte wasting (e.g., Fanconi's syndrome, renal tubular acidosis) 62 Hypothermia 11 hypopigmentation Hypopigmentation hypoplasia Dental: teeth development Dental: periodontal disease Muscular/skeletal hypoplasia SEXUAL/REPRODUCTIVE FUNCTION Breast volume/hypoplasia hyposalivation Dry mouth/salivary gland (xerostomia) hypotension ALLERGY/IMMUNOLOGY Allergic reaction/hypersensitivity (including drug fever) BLOOD/BONE MARROW Adrenal insufficiency Neuroendocrine: ACTH deficiency Febrile neutropenia (fever of unknown origin without clinically or microbiologically documented infection)(anc <1.0 x 10e9/L, fever >=38.5 degrees C) Infection with unknown ANC -- Opportunistic infection associated with >=Grade 2 Lymphopenia Cytokine release syndrome/acute infusion reaction hypothalmic Thyroid function, low (hypothyroidism) hypothermia CONSTITUTIONAL SYMPTOMS Hypothermia Hemolysis (e.g., immune hemolytic anemia, drug-related hemolysis) CARDIAC ARRHYTHMIA Conduction abnormality/atrioventricular heart block -- Prolonged QTc interval Supraventricular and nodal arrhythmia -- Ventricular arrhythmia hypothyroidism ALLERGY/IMMUNOLOGY Autoimmune reaction Adrenal insufficiency Thyroid function, low (hypothyroidism) 1 18 hypophosphatemia - hypovolemic shock 62 of 133

63 -- H -- hypovolemic shock CARDIAC GENERAL hypoxia Hypotension Hemorrhage, CNS Hemorrhage, GI -- Hemorrhage, GU -- Hemorrhage, pulmonary/upper respiratory -- Hemorrhage/bleeding associated with surgery, intraoperative or postoperative Adult Respiratory Distress Syndrome (ARDS) Hypoxia hypovolemic shock - hypoxia 63 of 133

64 -- I -- ICP imbalance Hemorrhage, CNS 30 Dizziness Arachnoiditis/meningismus/radiculitis immune BLOOD/BONE MARROW idioventricular CARDIAC ARRHYTHMIA ileus Ventricular arrhythmia -- Colitis Enteritis (inflammation of the small bowel) Ileus, GI (functional obstruction of bowel, i.e., neuroconstipation) Necrosis, GI -- Obstruction, GI -- Perforation, GI -- Stricture/stenosis (including anastomotic), GI -- Typhlitis (cecal inflammation) Ulcer, GI -- Hemorrhage, GI -- Infection with unknown ANC -- Intra-operative injury impaction implant Hemolysis (e.g., immune hemolytic anemia, drug-related hemolysis) Opportunistic infection associated with >=Grade 2 Lymphopenia Viral hepatitis Cytokine release syndrome/acute infusion reaction Constipation Ileus, GI (functional obstruction of bowel, i.e., neuroconstipation) AUDITORY/EAR Hearing: patients with/without baseline audiogram and enrolled in a monitoring program Infection with unknown ANC -- Cataract illusions Psychosis (hallucinations/delusions) impotency SEXUAL/REPRODUCTIVE FUNCTION Erectile dysfunction 64 ICP - impulsive 64 of 133

65 -- I -- impulsive Cognitive disturbance incoherence Psychosis (hallucinations/delusions) incontinence Diarrhea Incontinence, anal Mucositis/stomatitis (functional/symptomatic) -- Proctitis Bladder spasms Incontinence, urinary incoordination Ataxia (incoordination) SEXUAL/REPRODUCTIVE FUNCTION infertile <1.0 x 10e9/L, fever >=38.5 degrees C) Infection with unknown ANC -- Opportunistic infection associated with >=Grade 2 Lymphopenia Viral hepatitis Arachnoiditis/meningismus/radiculitis Vaginitis (not due to infection) Neuroendocrine: gonadotropin secretion abnormality SEXUAL/REPRODUCTIVE FUNCTION Infertility/sterility induration Atrophy, skin Atrophy, subcutaneous fat Induration/fibrosis (skin and subcutaneous tissue) infarction See: cardiac ischemia infection Fibrosis-deep connective tissue Colitis, infectious (e.g., Clostridium difficile) Febrile neutropenia (fever of unknown origin without clinically or microbiologically documented infection)(anc infiltrates Pneumonitis/pulmonary infiltrates inflammation Injection site reaction/extravasation changes Colitis Enteritis (inflammation of the small bowel) Gastritis (including bile reflux gastritis) Mucositis/stomatitis (clinical exam) -- Mucositis/stomatitis (functional/symptomatic) -- Proctitis Typhlitis (cecal inflammation) impulsive - inflammation 65 of 133

66 -- I -- influenza-like infusion reaction See: cytokine release syndrome INR Ulcer, GI -- HEPATOBILIARY/PANCREAS Cholecystitis Colitis, infectious (e.g., Clostridium difficile) LYMPHATICS Lymphedema-related fibrosis Arthritis (non-septic) Myositis (inflammation/damage of muscle) Arachnoiditis/meningismus/radiculitis Myelitis Keratitis (corneal inflammation/corneal ulceration) Tumor flare Flu-like syndrome COAGULATION INR (International Normalized Ratio of prothrombin time) Hematoma Hemorrhage, CNS Hemorrhage, GI -- Hemorrhage, GU -- Hemorrhage, pulmonary/upper respiratory insomnia CONSTITUTIONAL SYMPTOMS insufficiency COAGULATION insulin Hemorrhage/bleeding associated with surgery, intraoperative or postoperative Petechiae/purpura (hemorrhage/bleeding into skin or mucosa) Insomnia Mood alteration -- Thrombotic microangiopathy (e.g., thrombotic thrombocytopenic purpura [TTP] or hemolytic uremic syndrome [HUS]) Adrenal insufficiency Fracture Pancreatic endocrine: glucose intolerance Glucose, serum-high (hyperglycemia) Glucose, serum-low (hypoglycemia) intercourse SEXUAL/REPRODUCTIVE FUNCTION Ejaculatory dysfunction Erectile dysfunction Orgasmic dysfunction Vaginal mucositis intercranial pressure influenza-like - intercranial pressure of 133

67 -- I -- Arachnoiditis/meningismus/radiculitis Hydrocephalus intestine Enteritis (inflammation of the small bowel) Ileus, GI (functional obstruction of bowel, i.e., neuroconstipation) Leak (including anastomotic), GI -- Malabsorption Obstruction, GI -- Perforation, GI -- Prolapse of stoma, GI Stricture/stenosis (including anastomotic), GI -- Ulcer, GI -- Hemorrhage, GI intraocular pressure Glaucoma intubation Apnea Adult Respiratory Distress Syndrome (ARDS) Dyspnea (shortness of breath) Edema, larynx Hypoxia Obstruction/stenosis of airway -- Prolonged intubation after pulmonary resection (>24 hrs after surgery) inversion Eyelid dysfunction Intra-operative injury -- intra-operative Hemorrhage/bleeding associated with surgery, intraoperative or postoperative Intra-operative injury -- intracranial pressure Hemorrhage, CNS Hydrocephalus involuntary movements ionized calcium See: calcium iron Ataxia (incoordination) Encephalopathy Extrapyramidal/involuntary movement/restlessness Seizure Tremor Nystagmus BLOOD/BONE MARROW Iron overload intestine - iron 67 of 133

68 -- I -- Hemorrhage, GI -- irrigation Hemorrhage, GU Peripheral arterial ischemia Visceral arterial ischemia (non-myocardial) isoenzyme See: CPK Cystitis 60 itching See: pruritus irritability Irritability (children <3 years of age) IVC Intra-operative injury -- irritation Keratitis (corneal inflammation/corneal ulceration) Ocular surface disease 53 VASCULAR Vessel injury-vein SEXUAL/REPRODUCTIVE FUNCTION Vaginitis (not due to infection) 65 ischemia ALLERGY/IMMUNOLOGY Vasculitis 1 CARDIAC GENERAL Cardiac ischemia/infarction 7 Colitis Enteritis (inflammation of the small bowel) Typhlitis (cecal inflammation) Colitis, infectious (e.g., Clostridium difficile) CNS cerebrovascular ischemia Syncope (fainting) 51 VASCULAR irrigation - IVC 68 of 133

69 -- J -- Jacksonian seizure Seizure jaundice BLOOD/BONE MARROW Hemolysis (e.g., immune hemolytic anemia, drug-related hemolysis) HEPATOBILIARY/PANCREAS Cholecystitis Liver dysfunction/failure (clinical) Pancreatitis Bilirubin (hyperbilirubinemia) jaw See: CN V Trismus (difficulty, restriction or pain when opening mouth) Neuropathy: cranial joint Infection with unknown ANC -- Intra-operative injury -- Infection with unknown ANC -- Arthritis (non-septic) Joint-effusion Joint-function Intra-operative injury jejunum Fistula, GI -- Necrosis, GI -- Obstruction, GI -- Perforation, GI -- Stricture/stenosis (including anastomotic), GI -- Ulcer, GI jugular Cytokine release syndrome/acute infusion reaction Intra-operative injury -- VASCULAR Vessel injury-vein Hemorrhage, GI junctional See: nodal Jacksonian seizure - junctional 69 of 133

70 -- K -- K+ See: potassium keratitis Dry eye syndrome Keratitis (corneal inflammation/corneal ulceration) Ocular surface disease keratoconjunctivitis Dry eye syndrome Ocular surface disease keratopathy Keratitis (corneal inflammation/corneal ulceration) Calcium, serum-high (hypercalcemia) Magnesium, serum-high (hypermagnesemia) Potassium, serum-high (hyperkalemia) Sodium, serum-low (hyponatremia) Fistula, GU -- Leak (including anastomotic), GU -- Perforation, GU -- Renal failure Intra-operative injury Kernig's sign Arachnoiditis/meningismus/radiculitis koilonychias Nail changes ketoacidosis Pancreatic endocrine: glucose intolerance Glucose, serum-high (hyperglycemia) 18 kyphosis GROWTH AND DEVELOPMENT Bone growth: spine kyphosis/lordosis 29 kidney Hemorrhage, GU -- Infection with unknown ANC -- K+ - kyphosis 70 of 133

71 -- L -- L-spine lacrimation lactation lactic acid lacunas Lumbar spine-range of motion Dry eye syndrome Watery eye (epiphora, tearing) Neuroendocrine: prolactin hormone secretion abnormality SEXUAL/REPRODUCTIVE FUNCTION Breast function/lactation Acidosis (metabolic or respiratory) Leukoencephalopathy (radiographic findings) Edema, larynx Obstruction/stenosis of airway -- Recurrent laryngeal nerve dysfunction Voice changes/dysarthria (e.g., hoarseness, loss or alteration in voice, laryngitis) Intra-operative injury -- laryngectomy Edema, larynx Voice changes/dysarthria (e.g., hoarseness, loss or alteration in voice, laryngitis) laryngismus Obstruction/stenosis of airway -- laryngitis See: dysarthria language AUDITORY/EAR Hearing: patients with/without baseline audiogram and enrolled in a monitoring program Speech impairment (e.g., dysphasia or aphasia) 2 51 laryngospasm ALLERGY/IMMUNOLOGY Allergic reaction/hypersensitivity (including drug fever) Voice changes/dysarthria (e.g., hoarseness, loss or alteration in voice, laryngitis) 1 59 laryngeal Laryngeal nerve dysfunction Neuropathy: motor Speech impairment (e.g., dysphasia or aphasia) 51 larynx See: CN X Mucositis/stomatitis (clinical exam) -- Mucositis/stomatitis (functional/symptomatic) L-spine - larynx 71 of 133

72 -- L -- See: CN X Hemorrhage, pulmonary/upper respiratory -- Infection with unknown ANC -- Neuropathy: cranial -- Leak, cerebrospinal fluid (CSF) Prolonged chest tube drainage or air leak after pulmonary resection Leak (including anastomotic), GU -- Acute vascular leak syndrome VASCULAR Acute vascular leak syndrome laxatives leak Edema, larynx Fistula, pulmonary/upper respiratory -- Obstruction/stenosis of airway -- Intra-operative injury -- Constipation Incontinence, anal Fistula, GI -- Gastritis (including bile reflux gastritis) Leak (including anastomotic), GI -- Perforation, GI -- Prolapse of stoma, GI LYMPHATICS Chyle or lymph leakage learning problems lens leptomeningitis lesions Cognitive disturbance Infection with unknown ANC -- Cataract Intra-operative injury -- Arachnoiditis/meningismus/radiculitis Rash/desquamation laxatives - lesions 72 of 133

73 -- L -- lethargy leukemia Ulcer, GI -- Petechiae/purpura (hemorrhage/bleeding into skin or mucosa) CONSTITUTIONAL SYMPTOMS Fatigue (asthenia, lethargy, malaise) HEPATOBILIARY/PANCREAS Liver dysfunction/failure (clinical) Magnesium, serum-low (hypomagnesemia) Muscle weakness, generalized or specific area (not due to neuropathy) -- Hydrocephalus Mental status Cytokine release syndrome/acute infusion reaction SECONDARY MALIGNANCY Secondary Malignancy - possibly related to cancer treatment (Specify, ) leukocytes BLOOD/BONE MARROW Leukocytes (total WBC) Infection with unknown ANC leukocytosis leukoencephalopathy leukopenia ALLERGY/IMMUNOLOGY level of consciousness COAGULATION Lhermitte sign libido "Retinoic acid syndrome" Leukoencephalopathy (radiographic findings) Autoimmune reaction Thrombotic microangiopathy (e.g., thrombotic thrombocytopenic purpura [TTP] or hemolytic uremic syndrome [HUS]) Arachnoiditis/meningismus/radiculitis Mental status Seizure Somnolence/depressed level of consciousness Myelitis SEXUAL/REPRODUCTIVE FUNCTION Libido lid See: eyelid light sensitivity Vision-photophobia lethargy - lightheadedness 73 of 133

74 -- L -- lightheadedness CARDIAC ARRHYTHMIA Conduction abnormality/atrioventricular heart block -- Palpitations Vasovagal episode CARDIAC GENERAL Hypotension Dizziness Syncope (fainting) lipids lips Lipase Cholesterol, serum-high (hypercholestremia) Lipase Chelitis 14 limb GROWTH AND DEVELOPMENT Bone growth: limb length discrepancy LYMPHATICS Edema: limb Extremity-lower (gait/walking) Extremity-upper (function) Fibrosis-deep connective tissue Local complication -device/prosthesis-related Dry mouth/salivary gland (xerostomia) Infection with unknown ANC -- Intra-operative injury -- "Retinoic acid syndrome" VASCULAR limp See: limb lipase Peripheral arterial ischemia Vessel injury-artery -- HEPATOBILIARY/PANCREAS Pancreatitis liver Fistula, GI -- Leak (including anastomotic), GI -- Necrosis, GI -- Perforation, GI -- Stricture/stenosis (including anastomotic), GI -- Hemorrhage, GI lightheadedness - liver 74 of 133

75 -- L -- HEPATOBILIARY/PANCREAS liver enzymes See: AST, ALT LOC lockjaw Liver dysfunction/failure (clinical) Infection with unknown ANC -- Viral hepatitis AST, SGOT(serum glutamic oxaloacetic transaminase) Bilirubin (hyperbilirubinemia) Intra-operative injury -- Hemorrhage, CNS Arachnoiditis/meningismus/radiculitis Seizure Somnolence/depressed level of consciousness Trismus (difficulty, restriction or pain when opening mouth) loneliness Mood alteration lordosis GROWTH AND DEVELOPMENT Bone growth: spine kyphosis/lordosis lymphangiosarcoma LYMPHATICS Edema: limb Edema: trunk/genital lymphatic CONSTITUTIONAL SYMPTOMS Weight gain Infection with unknown ANC -- LYMPHATICS Chyle or lymph leakage Dermal change lymphedema, phlebolymphedema Edema: head and neck Edema: limb Edema: trunk/genital Edema: viscera Lymphedema-related fibrosis Lymphocele Phlebolymphatic cording lymphedema liver enzymes - lymphedema 75 of 133

76 -- L -- See: lymphatic lymphocele LYMPHATICS Lymphocele lymphocytes BLOOD/BONE MARROW CD4 count Lymphopenia Opportunistic infection associated with >=Grade 2 Lymphopenia lymphoedema See: lymphatic lymphoma SECONDARY MALIGNANCY Secondary Malignancy - possibly related to cancer treatment (Specify, ) 63 lymphopenia See: lymphocytes lymphorrhea See: lymphatic lysis Uric acid, serum-high (hyperuricemia) Tumor flare Tumor lysis syndrome VASCULAR Thrombosis/embolism (vascular access-related) Thrombosis/thrombus/embolism lymphocele - lysis 76 of 133

77 -- M -- macular malnutrition Rash/desquamation Optic disc edema Retinal detachment Retinopathy Anorexia Malabsorption Nausea Vomiting mammary gland madarosis Eyelid dysfunction SEXUAL/REPRODUCTIVE FUNCTION Breast function/lactation Gynecomastia magnesium Magnesium, serum-high (hypermagnesemia) Magnesium, serum-low (hypomagnesemia) masculinization of female Cushingoid appearance (e.g., moon face, buffalo hump, centripetal obesity, cutaneous striae) Masculinization of female malabsorption Pancreatic endocrine: glucose intolerance Malabsorption HEPATOBILIARY/PANCREAS Pancreas, exocrine enzyme deficiency mastoiditis AUDITORY/EAR maxilla Otitis, external ear (non-infectious) Otitis, middle ear (non-infectious) Dental: periodontal disease malaise CONSTITUTIONAL SYMPTOMS Fatigue (asthenia, lethargy, malaise) Muscle weakness, generalized or specific area (not due to neuropathy) -- Cytokine release syndrome/acute infusion reaction Flu-like syndrome MDS SECONDARY MALIGNANCY Secondary Malignancy - possibly related to cancer treatment (Specify, ) mediastinal Hemorrhage, pulmonary/upper respiratory macular - mediastinal 77 of 133

78 -- M -- Infection with unknown ANC -- Intra-operative injury -- Infection with unknown ANC -- Arachnoiditis/meningismus/radiculitis Intra-operative injury -- megacolon melena Colitis Constipation Colitis, infectious (e.g., Clostridium difficile) ALLERGY/IMMUNOLOGY Autoimmune reaction CONSTITUTIONAL SYMPTOMS Weight loss meningismus See: arachnoiditis meningitis See: meninges Infection with unknown ANC -- Arachnoiditis/meningismus/radiculitis Colitis memory Hemorrhage, GI -- Confusion Memory impairment menometrorrhagia Hemorrhage, GU -- menopause Hot flashes/flushes SEXUAL/REPRODUCTIVE FUNCTION Irregular menses (change from baseline) 64 meninges menorrhagia Thyroid function, low (hypothyroidism) Hemorrhage, GU megacolon - menses 78 of 133

79 -- M -- menses menstruation See: menses metabolic metallic taste MI SEXUAL/REPRODUCTIVE FUNCTION Irregular menses (change from baseline) Neuroendocrine: growth hormone secretion abnormality Thyroid function, low (hypothyroidism) Acidosis (metabolic or respiratory) Alkalosis (metabolic or respiratory) Salivary gland changes/saliva CARDIAC GENERAL Cardiac ischemia/infarction Cardiac troponin I (ctni) CPK (creatine phosphokinase) VASCULAR Vessel injury-artery Mini-Mental See: Folstein Mini-Mental Exam MMSE See: Folstein Mini-Mental Exam Mobitz See: atrioventricular rhythm mood Mental status Encephalopathy Mood alteration -- moon face Cushingoid appearance (e.g., moon face, buffalo hump, centripetal obesity, cutaneous striae) motion sickness Nausea Neuropathy: cranial microangiopathy COAGULATION Thrombotic microangiopathy (e.g., thrombotic thrombocytopenic purpura [TTP] or hemolytic uremic syndrome [HUS]) migrane 10 motor Neuropathy: cranial -- Neuropathy: motor Pyramidal tract dysfunction (e.g., increased tone, hyperreflexia, positive Babinski, decreased fine motor coordination) Seizure menses - motor 79 of 133

80 -- M -- Intra-operative injury -- DEATH Death not associated with CTCAE term mucosa SEXUAL/REPRODUCTIVE FUNCTION mucus MUGA Dehydration Mucositis/stomatitis (clinical exam) -- Mucositis/stomatitis (functional/symptomatic) -- Salivary gland changes/saliva Petechiae/purpura (hemorrhage/bleeding into skin or mucosa) Infection with unknown ANC -- Nasal cavity/paranasal sinus reactions Vaginal mucositis Colitis Enteritis (inflammation of the small bowel) Typhlitis (cecal inflammation) Colitis, infectious (e.g., Clostridium difficile) CARDIAC GENERAL Left ventricular systolic dysfunction multi-organ failure muscle musculoskeletal See: muscle myalgia Infection with unknown ANC -- Extremity-lower (gait/walking) Extremity-upper (function) Fibrosis-deep connective tissue Muscle weakness, generalized or specific area (not due to neuropathy) -- Muscular/skeletal hypoplasia Myositis (inflammation/damage of muscle) Brachial plexopathy Neuropathy: cranial -- Ocular muscle weakness Intra-operative injury -- Cytokine release syndrome/acute infusion reaction mucosa - myalgia 80 of 133

81 -- M -- myelitis Cytokine release syndrome/acute infusion reaction Flu-like syndrome Infection with unknown ANC Infection with unknown ANC -- Myositis (inflammation/damage of muscle) myxedema Thyroid function, low (hypothyroidism) Myelitis 49 myelodysplasia BLOOD/BONE MARROW Myelodysplasia 4 myocardial See: cardiac ischemia myocardial infarction CARDIAC GENERAL Cardiac ischemia/infarction Cardiac troponin I (ctni) 7 7 CPK (creatine phosphokinase) myocarditis CARDIAC GENERAL Myocarditis 8 myositis myelitis - myxedema 81 of 133

82 -- N -- Na+ See: sodium nails narrowing CARDIAC GENERAL SEXUAL/REPRODUCTIVE FUNCTION nasal ALLERGY/IMMUNOLOGY nausea Nail changes Infection with unknown ANC -- Intra-operative injury -- Cardiac ischemia/infarction Stricture/stenosis (including anastomotic), GI -- Stricture/stenosis (including anastomotic), GU -- Vaginal stenosis/length Allergic rhinitis (including sneezing, nasal stuffiness, postnasal drip) Nasal cavity/paranasal sinus reactions Intra-operative injury HEPATOBILIARY/PANCREAS neck Ileus, GI (functional obstruction of bowel, i.e., neuroconstipation) Nausea Obstruction, GI -- Ulcer, GI -- Vomiting Pancreatitis Magnesium, serum-low (hypomagnesemia) Arachnoiditis/meningismus/radiculitis Dizziness Cytokine release syndrome/acute infusion reaction Infection with unknown ANC -- LYMPHATICS Edema: head and neck Cervical spine-range of motion Soft tissue necrosis -- Intra-operative injury -- necrolysis Na+ - necrolysis 82 of 133

83 -- N -- Rash: erythema multiforme (e.g., Stevens-Johnson syndrome, toxic epidermal necrolysis) Osteonecrosis (avascular necrosis) Soft tissue necrosis necrosis Leukoencephalopathy (radiographic findings) 49 AUDITORY/EAR Otitis, external ear (non-infectious) Otitis, middle ear (non-infectious) Injection site reaction/extravasation changes Rash: dermatitis associated with radiation -- Colitis Dental: periodontal disease Enteritis (inflammation of the small bowel) Mucositis/stomatitis (clinical exam) -- Necrosis, GI -- Salivary gland changes/saliva Typhlitis (cecal inflammation) GROWTH AND DEVELOPMENT Scleral necrosis/melt Nasal cavity/paranasal sinus reactions SEXUAL/REPRODUCTIVE FUNCTION Vaginal mucositis necrotizing fascitis Wound complication, non-infectious Infection with unknown ANC Bone growth: femoral head; slipped capital femoral epiphysis Colitis, infectious (e.g., Clostridium difficile) Febrile neutropenia (fever of unknown origin without clinically or microbiologically documented infection)(anc <1.0 x 10e9/L, fever >=38.5 degrees C) Infection with unknown ANC -- Opportunistic infection associated with >=Grade 2 Lymphopenia 29 nerve Infection with unknown ANC -- Laryngeal nerve dysfunction Neuropathy: cranial -- Neuropathy: motor Neuropathy: sensory Phrenic nerve dysfunction Speech impairment (e.g., dysphasia or aphasia) 51 necrosis - nerve 83 of 133

84 -- N -- GROWTH AND DEVELOPMENT Short stature 29 Voice changes/dysarthria (e.g., hoarseness, loss or alteration in voice, laryngitis) 59 neurogenic bladder Urinary retention (including neurogenic bladder) 62 Intra-operative injury -- neurologic neuralgia neuritis Brachial plexopathy Neuropathy: motor Dysphagia (difficulty swallowing) Hemorrhage, CNS CNS cerebrovascular ischemia Hydrocephalus Syncope (fainting) neuroconstipation Constipation Distension/bloating, abdominal Ileus, GI (functional obstruction of bowel, i.e., neuroconstipation) Typhlitis (cecal inflammation) neuroendocrine Neuroendocrine: ACTH deficiency Neuroendocrine: ADH secretion abnormality (e.g., SIADH or low ADH) Neuroendocrine: gonadotropin secretion abnormality Neuroendocrine: growth hormone secretion abnormality Neuroendocrine: prolactin hormone secretion abnormality neuropathy Fibrosis-deep connective tissue Muscle weakness, generalized or specific area (not due to neuropathy) -- Neuropathy: cranial -- Neuropathy: motor Neuropathy: sensory Speech impairment (e.g., dysphasia or aphasia) Eyelid dysfunction Ocular muscle weakness neutropenia Febrile neutropenia (fever of unknown origin without clinically or microbiologically documented infection)(anc <1.0 x 10e9/L, fever >=38.5 degrees C) neuralgia - neutropenia 84 of 133

85 -- N -- neutrophils BLOOD/BONE MARROW night blindness nipple Infection with unknown ANC -- SEXUAL/REPRODUCTIVE FUNCTION nocturia Neutrophils/granulocytes (ANC/AGC) Febrile neutropenia (fever of unknown origin without clinically or microbiologically documented infection)(anc <1.0 x 10e9/L, fever >=38.5 degrees C) Infection with unknown ANC -- Night blindness (nyctalopia) Breast nipple/areolar deformity Urinary frequency/urgency nodal See: supraventricular and nodal arrhythmia non-autologous Hemorrhage/bleeding associated with surgery, intraoperative or postoperative non-essential organ ALLERGY/IMMUNOLOGY nose NSAIDS Autoimmune reaction Hemorrhage, pulmonary/upper respiratory -- Infection with unknown ANC -- Intra-operative injury -- Cytokine release syndrome/acute infusion reaction nuccal rigidity Arachnoiditis/meningismus/radiculitis numbness Neuropathy: sensory nyctalopia Night blindness (nyctalopia) nystagmus Dizziness Nystagmus neutrophils - nystagmus 85 of 133

86 -- O -- obesity CONSTITUTIONAL SYMPTOMS Obesity Weight gain Cushingoid appearance (e.g., moon face, buffalo hump, centripetal obesity, cutaneous striae) obstipation Colitis Constipation Ileus, GI (functional obstruction of bowel, i.e., neuroconstipation) Colitis, infectious (e.g., Clostridium difficile) obtundation ocular Obstruction/stenosis of airway -- Obstruction, GU -- Prolapse of stoma, GU Somnolence/depressed level of consciousness Infection with unknown ANC obstruction ALLERGY/IMMUNOLOGY Allergic rhinitis (including sneezing, nasal stuffiness, postnasal drip) Constipation Distension/bloating, abdominal Dysphagia (difficulty swallowing) Ileus, GI (functional obstruction of bowel, i.e., neuroconstipation) Obstruction, GI -- Prolapse of stoma, GI Typhlitis (cecal inflammation) Muscle weakness, generalized or specific area (not due to neuropathy) -- Neuropathy: cranial -- Glaucoma Ocular muscle weakness Ocular surface disease Vitreous hemorrhage LYMPHATICS Dermal change lymphedema, phlebolymphedema 38 Intra-operative injury -- Hydrocephalus Nasal cavity/paranasal sinus reactions 58 oculomotor See: CN III odor obesity - odor 86 of 133

87 -- O -- CONSTITUTIONAL SYMPTOMS Odor (patient odor) Neuropathy: cranial -- odynophagia Dysphagia (difficulty swallowing) olfactory See: CN I opportunistic infection Opportunistic infection associated with >=Grade 2 Lymphopenia optic disc Neuropathy: cranial -- Optic disc edema Intra-operative injury oligospermia SEXUAL/REPRODUCTIVE FUNCTION oliguria Infertility/sterility COAGULATION DIC (disseminated intravascular coagulation) Dehydration optic nerve See: CN II orgasm SEXUAL/REPRODUCTIVE FUNCTION Orgasmic dysfunction orthostatic hypotension See: hypotension 65 Renal failure 61 osteoarthritis See: arthritis ophthalmologic changes Cataract Glaucoma Keratitis (corneal inflammation/corneal ulceration) Ocular surface disease Optic disc edema Retinal detachment Retinopathy Scleral necrosis/melt Uveitis Vitreous hemorrhage osteochondroma Exostosis osteomalacia Phosphate, serum-low (hypophosphatemia) osteomyelitis AUDITORY/EAR Otitis, external ear (non-infectious) 43 2 odynophagia - osteomyelitis 87 of 133

88 -- O -- otalgia Infection with unknown ANC -- AUDITORY/EAR otitis Earache (otalgia) AUDITORY/EAR 2 osteonecrosis Dental: periodontal disease Osteonecrosis (avascular necrosis) osteopenia Otitis, external ear (non-infectious) Otitis, middle ear (non-infectious) Infection with unknown ANC Neuroendocrine: gonadotropin secretion abnormality Osteoporosis 46 ototoxicity AUDITORY/EAR ovary Hearing: patients with/without baseline audiogram and enrolled in a monitoring program 2 osteophytosis Hemorrhage, GU -- Exostosis 43 osteoporosis Osteoporosis 46 Perforation, GU -- Intra-operative injury ostomy Diarrhea Prolapse of stoma, GI Prolapse of stoma, GU Intra-operative injury ovulation Neuroendocrine: prolactin hormone secretion abnormality SEXUAL/REPRODUCTIVE FUNCTION Infertility/sterility 64 osteonecrosis - ovulation 88 of 133

89 -- P -- pacemaker See: atrioventricular rhythm Hemorrhage, GI palate See: CN X paleness palpitations palsy Neuropathy: cranial -- Hypopigmentation CARDIAC ARRHYTHMIA Palpitations Supraventricular and nodal arrhythmia -- Calcium, serum-low (hypocalcemia) Tremor pan-uveitis Uveitis pancreas Pancreatic endocrine: glucose intolerance Fistula, GI -- Leak (including anastomotic), GI -- Necrosis, GI -- Stricture/stenosis (including anastomotic), GI HEPATOBILIARY/PANCREAS pancreatitis HEPATOBILIARY/PANCREAS papillary formation LYMPHATICS papilloma papular Pancreas, exocrine enzyme deficiency Pancreatitis Infection with unknown ANC -- Amylase Lipase Intra-operative injury -- Pancreatitis Amylase Lipase Dermal change lymphedema, phlebolymphedema Voice changes/dysarthria (e.g., hoarseness, loss or alteration in voice, laryngitis) Rash/desquamation pacemaker - paracentesis 89 of 133

90 -- P -- paracentesis Ascites (non-malignant) 19 Calcium, serum-low (hypocalcemia) 40 paralysis Hemorrhage, CNS CNS cerebrovascular ischemia Neuropathy: motor Phrenic nerve dysfunction Pyramidal tract dysfunction (e.g., increased tone, hyperreflexia, positive Babinski, decreased fine motor coordination) paranasal Infection with unknown ANC -- Nasal cavity/paranasal sinus reactions parasthesia See: paresthesia parathyroid Parathyroid function, low (hypoparathyroidism) Magnesium, serum-low (hypomagnesemia) Intra-operative injury parotid PD See: progressive disease PE Brachial plexopathy Neuropathy: sensory VASCULAR pediatric Intra-operative injury -- Dyspnea (shortness of breath) Thrombosis/embolism (vascular access-related) Thrombosis/thrombus/embolism AUDITORY/EAR Hearing: patients with/without baseline audiogram and enrolled in a monitoring program Hearing: patients without baseline audiogram and not enrolled in a monitoring program CARDIAC GENERAL Hypertension Hemorrhage/bleeding associated with surgery, intraoperative or postoperative Creatinine paresthesia peeling paracentesis - peeling 90 of 133

91 -- P -- Photosensitivity Rash: hand-foot skin reaction peliosis pelvic See: pelvis pelvis Petechiae/purpura (hemorrhage/bleeding into skin or mucosa) Infection with unknown ANC -- Fracture Muscle weakness, generalized or specific area (not due to neuropathy) -- Soft tissue necrosis -- Fistula, GU -- Intra-operative injury SEXUAL/REPRODUCTIVE FUNCTION Ejaculatory dysfunction Erectile dysfunction Intra-operative injury -- perforation AUDITORY/EAR Otitis, external ear (non-infectious) Colitis Dysphagia (difficulty swallowing) Enteritis (inflammation of the small bowel) Perforation, GI -- Proctitis Typhlitis (cecal inflammation) HEPATOBILIARY/PANCREAS Cholecystitis Colitis, infectious (e.g., Clostridium difficile) Keratitis (corneal inflammation/corneal ulceration) Perforation, GU penis Infection with unknown ANC -- periarteritis nodosa ALLERGY/IMMUNOLOGY Autoimmune reaction pericardial effusion CARDIAC GENERAL Pericardial effusion (non-malignant) 1 8 peliosis - perineum 91 of 133

92 -- P -- perineum periodontal Dental: periodontal disease perirectal peristomal Prolapse of stoma, GI Infection with unknown ANC -- Prolapse of stoma, GU peritoneum Ascites (non-malignant) Colitis Enteritis (inflammation of the small bowel) Necrosis, GI -- Typhlitis (cecal inflammation) Hemorrhage, GI peritonitis personality petechiae petit mal See: seizure ph Infection with unknown ANC -- Intra-operative injury -- Personality/behavioral COAGULATION Thrombotic microangiopathy (e.g., thrombotic thrombocytopenic purpura [TTP] or hemolytic uremic syndrome [HUS]) Petechiae/purpura (hemorrhage/bleeding into skin or mucosa) Acidosis (metabolic or respiratory) Alkalosis (metabolic or respiratory) phantom limb pain perineum - pharynx 92 of 133

93 -- P -- pharynx See: CN IX, CN X Fistula, GI -- Leak (including anastomotic), GI -- Mucositis/stomatitis (clinical exam) -- Mucositis/stomatitis (functional/symptomatic) -- Necrosis, GI -- Stricture/stenosis (including anastomotic), GI -- Hemorrhage, pulmonary/upper respiratory -- Infection with unknown ANC LYMPHATICS Phlebolymphatic cording phlebolymphedema LYMPHATICS Dermal change lymphedema, phlebolymphedema phosphate Phosphate, serum-low (hypophosphatemia) photophobia Arachnoiditis/meningismus/radiculitis Vision-photophobia phlebitis Neuropathy: cranial -- Fistula, pulmonary/upper respiratory -- Obstruction/stenosis of airway -- Intra-operative injury -- Injection site reaction/extravasation changes VASCULAR Phlebitis (including superficial thrombosis) Thrombosis/embolism (vascular access-related) phlebolymphatic cording photopsia Vision-flashing lights/floaters photosensitivity Photosensitivity Arachnoiditis/meningismus/radiculitis Vision-photophobia phrenic nerve dysfunction Phrenic nerve dysfunction pigmentation Hyperpigmentation pharynx - pigmentation 93 of 133

94 -- P -- Hypopigmentation Adrenal insufficiency Petechiae/purpura (hemorrhage/bleeding into skin or mucosa) 14 prolactin hormone secretion abnormality Thyroid function, high (hyperthyroidism, thyrotoxicosis) GROWTH AND DEVELOPMENT Short stature Intra-operative injury piles Hemorrhoids 22 PJC CARDIAC ARRHYTHMIA Supraventricular and nodal arrhythmia -- 5 pink eye Ocular surface disease 53 platelets BLOOD/BONE MARROW Platelets 4 pinna pitting Intra-operative injury -- Nail changes LYMPHATICS Edema: limb Edema: trunk/genital pleura Hematoma Hemorrhage, CNS Hemorrhage, GI -- Hemorrhage, GU -- Hemorrhage, pulmonary/upper respiratory -- Hemorrhage/bleeding associated with surgery, intraoperative or postoperative Petechiae/purpura (hemorrhage/bleeding into skin or mucosa) CONSTITUTIONAL SYMPTOMS pituitary Neuroendocrine: ADH secretion abnormality (e.g., SIADH or low ADH) Neuroendocrine: gonadotropin secretion abnormality Neuroendocrine: growth hormone secretion abnormality Neuroendocrine: Weight gain Hemorrhage, pulmonary/upper respiratory -- Infection with unknown ANC piles - pleura 94 of 133

95 -- P -- Pneumonitis/pulmonary infiltrates Pneumothorax Dyspnea (shortness of breath) Fistula, pulmonary/upper respiratory -- Pleural effusion (non-malignant) Intra-operative injury -- pleural effusion See: pleura pneumonitis Aspiration Pneumonitis/pulmonary infiltrates Pulmonary fibrosis (radiographic changes) pneumothorax Pneumothorax pleurodesis Pleural effusion (non-malignant) 58 pollakiuria Urinary frequency/urgency 62 plexopathy Brachial plexopathy polyarthritis Arthritis (non-septic) 43 plication See: diaphragmatic plication PNC CARDIAC ARRHYTHMIA Supraventricular and nodal arrhythmia -- 5 porokeratosis Rash/desquamation pneumonia Infection with unknown ANC -- Aspiration Dyspnea (shortness of breath) poroma Exostosis portal vein Intra-operative injury -- VASCULAR Portal vein flow pleural effusion - post-infectious neuralgia 95 of 133

96 -- P -- post-infectious neuralgia postictal See: seizure operative or postoperative precocious GROWTH AND DEVELOPMENT Puberty (precocious) 29 postmenopausal Osteoporosis postnasal drip ALLERGY/IMMUNOLOGY Allergic rhinitis (including sneezing, nasal stuffiness, postnasal drip) 46 1 premature CARDIAC ARRHYTHMIA Supraventricular and nodal arrhythmia -- Ventricular arrhythmia -- pressure Skin breakdown/decubitus ulcer postural imbalance potassium prbc Ataxia (incoordination) Adrenal insufficiency Cushingoid appearance (e.g., moon face, buffalo hump, centripetal obesity, cutaneous striae) Potassium, serum-high (hyperkalemia) Potassium, serum-low (hypokalemia) Uric acid, serum-high (hyperuricemia) Hematoma Hemorrhage, CNS Hemorrhage, GI -- Hemorrhage, GU -- Hemorrhage, pulmonary/upper respiratory -- Hemorrhage/bleeding associated with surgery, intra proctalgia proctitis Glaucoma Proctitis Proctitis progesterone Neuroendocrine: prolactin hormone secretion abnormality progressive disease DEATH post-infectious neuralgia - progressive disease 96 of 133

97 -- P -- Death not associated with CTCAE term prolactin Intra-operative injury -- prosthesis Neuroendocrine: prolactin hormone secretion abnormality prolapse Prolapse of stoma, GI Prolapse of stoma, GU promyelocytic "Retinoic acid syndrome" Dental: dentures or prosthesis Infection with unknown ANC -- Local complication -device/prosthesis-related Muscular/skeletal hypoplasia proptosis SEXUAL/REPRODUCTIVE FUNCTION Erectile dysfunction 64 Proptosis/enophthalmos 53 prostration prostate Flu-like syndrome 68 Hemorrhage, GU -- Infection with unknown ANC -- Obstruction, GU -- Perforation, GU -- Stricture/stenosis (including anastomotic), GU protein proteinuria prothrombin time COAGULATION pruritis Magnesium, serum-low (hypomagnesemia) Proteinuria Proteinuria INR (International Normalized Ratio of prothrombin time) prolactin - pruritis 97 of 133

98 -- P -- See: pruritus Psychosis (hallucinations/delusions) pruritus ALLERGY/IMMUNOLOGY Allergic reaction/hypersensitivity (including drug fever) Injection site reaction/extravasation changes Pruritus/itching Rash/desquamation Rash: acne/acneiform Rash: dermatitis associated with radiation -- Rash: erythema multiforme (e.g., Stevens-Johnson syndrome, toxic epidermal necrolysis) Rash: hand-foot skin reaction Bilirubin (hyperbilirubinemia) SEXUAL/REPRODUCTIVE FUNCTION Vaginitis (not due to infection) Cytokine release syndrome/acute infusion reaction pseudocysts HEPATOBILIARY/PANCREAS Pancreatitis pseudohypoparathyroidism Parathyroid function, low (hypoparathyroidism) pseudomembranes Mucositis/stomatitis (clinical exam) -- psychosis Encephalopathy PT See: INR PTT COAGULATION puberty PTT (Partial Thromboplastin Time) Hematoma Hemorrhage, CNS Hemorrhage, GI -- Hemorrhage, GU -- Hemorrhage, pulmonary/upper respiratory -- Hemorrhage/bleeding associated with surgery, intraoperative or postoperative Petechiae/purpura (hemorrhage/bleeding into skin or mucosa) GROWTH AND DEVELOPMENT Puberty (delayed) Puberty (precocious) pulmonale CARDIAC GENERAL Right ventricular dysfunction (cor pulmonale) pulmonary edema CARDIAC GENERAL Pulmonary hypertension Restrictive cardiomyopathy Right ventricular dysfunction (cor pulmonale) Dyspnea (shortness of breath) VASCULAR pruritus - pulmonary edema 98 of 133

99 -- P -- Acute vascular leak syndrome 70 defined as ANC <1.0 x 10e9/L) pupil See: CN III purpura Neuropathy: cranial -- ALLERGY/IMMUNOLOGY Autoimmune reaction 1 pyrosis Febrile neutropenia (fever of unknown origin without clinically or microbiologically documented infection)(anc <1.0 x 10e9/L, fever >=38.5 degrees C) Heartburn/dyspepsia 22 COAGULATION DIC (disseminated intravascular coagulation) Fibrinogen INR (International Normalized Ratio of prothrombin time) PTT (Partial Thromboplastin Time) Thrombotic microangiopathy (e.g., thrombotic thrombocytopenic purpura [TTP] or hemolytic uremic syndrome [HUS]) Bruising (in absence of Grade 3 or 4 thrombocytopenia) Petechiae/purpura (hemorrhage/bleeding into skin or mucosa) PVCs CARDIAC ARRHYTHMIA Ventricular arrhythmia -- 6 pyramidal tract dysfunction Pyramidal tract dysfunction (e.g., increased tone, hyperreflexia, positive Babinski, decreased fine motor coordination) 51 pyrexia CONSTITUTIONAL SYMPTOMS Fever (in the absence of neutropenia, where neutropenia is 11 pupil - pyrosis 99 of 133

100 -- Q -- QTc CARDIAC ARRHYTHMIA Prolonged QTc interval queasy Nausea 5 24 QTc - queasy 100 of 133

101 -- R -- rachioscoliosis Bone: spine-scoliosis 43 Lumbar spine-range of motion Trismus (difficulty, restriction or pain when opening mouth) radiation LYMPHATICS radiculitis See: arachnoiditis RAEB Burn Rash: dermatitis associated with radiation -- Mucositis/stomatitis (clinical exam) -- Mucositis/stomatitis (functional/symptomatic) -- Proctitis Hemorrhage, GI -- Hemorrhage, GU -- Hemorrhage, pulmonary/upper respiratory -- Dermal change lymphedema, phlebolymphedema Trismus (difficulty, restriction or pain when opening mouth) Pulmonary fibrosis (radiographic changes) BLOOD/BONE MARROW Myelodysplasia range of motion LYMPHATICS Phlebolymphatic cording Cervical spine-range of motion Joint-function rapid eye movements rash ALLERGY/IMMUNOLOGY RBC Nystagmus Allergic reaction/hypersensitivity (including drug fever) Rash/desquamation Rash: acne/acneiform Rash: dermatitis associated with radiation -- Rash: erythema multiforme (e.g., Stevens-Johnson syndrome, toxic epidermal necrolysis) Rash: hand-foot skin reaction Cytokine release syndrome/acute infusion reaction BLOOD/BONE MARROW Hemolysis (e.g., immune hemolytic anemia, drug-related hemolysis) COAGULATION Thrombotic microangiopathy (e.g., thrombotic thrombocytopenic purpura [TTP] or hemolytic uremic syndrome [HUS]) Hematoma Hemorrhage, CNS Hemorrhage, GI -- Hemorrhage, GU -- Hemorrhage, pulmonary/upper respiratory -- Hemorrhage/bleeding associated with surgery, intraoperative or postoperative rachioscoliosis - RBC 101 of 133

102 -- R -- Petechiae/purpura (hemorrhage/bleeding into skin or mucosa) receptive dysphasia Speech impairment (e.g., dysphasia or aphasia) 51 Infection with unknown ANC -- reconstruction rectitis See: proctitis rectum Burn Skin breakdown/decubitus ulcer Ulceration Wound complication, non-infectious Local complication -device/prosthesis-related Soft tissue necrosis -- Intra-operative injury -- Fistula, GI -- Leak (including anastomotic), GI -- Mucositis/stomatitis (clinical exam) -- Mucositis/stomatitis (functional/symptomatic) -- Necrosis, GI -- Obstruction, GI -- Perforation, GI -- Proctitis Stricture/stenosis (including anastomotic), GI -- Ulcer, GI reflexes reflux Intra-operative injury -- Neuropathy: sensory Esophagitis Gastritis (including bile reflux gastritis) Heartburn/dyspepsia regional ileitis Colitis Colitis, infectious (e.g., Clostridium difficile) regurgitation CARDIAC GENERAL Valvular heart disease Heartburn/dyspepsia Vomiting Hemorrhage, GI renal BLOOD/BONE MARROW receptive dysphasia - renal 102 of 133

103 -- R -- Hemolysis (e.g., immune hemolytic anemia, drug-related hemolysis) COAGULATION Thrombotic microangiopathy (e.g., thrombotic thrombocytopenic purpura [TTP] or hemolytic uremic syndrome [HUS]) 4 10 Intra-operative injury -- VASCULAR Vessel injury-artery -- Vessel injury-vein Hemorrhage, GU -- resection Creatinine Glomerular filtration rate Phosphate, serum-low (hypophosphatemia) Sodium, serum-low (hyponatremia) Uric acid, serum-high (hyperuricemia) Ulceration Wound complication, non-infectious Gastritis (including bile reflux gastritis) Necrosis, GI -- Obstruction, GI -- Stricture/stenosis (including anastomotic), GI Colitis, infectious (e.g., Clostridium difficile) repair Fistula, GU -- Obstruction, GU -- Perforation, GU -- Renal failure Stricture/stenosis (including anastomotic), GU -- Urinary electrolyte wasting (e.g., Fanconi's syndrome, renal tubular acidosis) Cytokine release syndrome/acute infusion reaction Dental: teeth Prolonged chest tube drainage or air leak after pulmonary resection Prolonged intubation after pulmonary resection (>24 hrs after surgery) Fistula, GU -- Obstruction, GU -- Perforation, GU -- Stricture/stenosis (including anastomotic), GU -- Urinary retention (including neurogenic bladder) Intra-operative injury Obstruction, GU -- Stricture/stenosis (including anastomotic), GU residual urine Urinary retention (including neurogenic bladder) 62 repair - respiration 103 of 133

104 -- R -- respiration CARDIAC GENERAL Left ventricular diastolic dysfunction Left ventricular systolic dysfunction Mucositis/stomatitis (functional/symptomatic) Extrapyramidal/involuntary movement/restlessness Irritability (children <3 years of age) restriction Dental: dentures or prosthesis 19 Hemorrhage, pulmonary/upper respiratory -- HEPATOBILIARY/PANCREAS Liver dysfunction/failure (clinical) Acidosis (metabolic or respiratory) Alkalosis (metabolic or respiratory) Magnesium, serum-high (hypermagnesemia) Apnea Phrenic nerve dysfunction Cervical spine-range of motion Trismus (difficulty, restriction or pain when opening mouth) "Retinoic acid syndrome" restrictive cardiomyopathy CARDIAC GENERAL Restrictive cardiomyopathy resuscitation Adult Respiratory Distress Syndrome (ARDS) Atelectasis Edema, larynx Fistula, pulmonary/upper respiratory -- Hypoxia Obstruction/stenosis of airway -- Pleural effusion (non-malignant) Pneumonitis/pulmonary infiltrates Pneumothorax "Retinoic acid syndrome" VASCULAR Acute vascular leak syndrome restlessness CARDIAC GENERAL retention retina Cardiopulmonary arrest, cause unknown (non-fatal) Urinary retention (including neurogenic bladder) "Retinoic acid syndrome" Glaucoma Retinal detachment Intra-operative injury -- Retinoic acid syndrome respiration - Retinoic acid syndrome 104 of 133

105 -- R -- "Retinoic acid syndrome" 69 postnasal drip) retinopathy retrograde ejaculation SEXUAL/REPRODUCTIVE FUNCTION retroperitoneum rhegmatogenous rheumatism See: arthritis rhinitis Retinopathy Ejaculatory dysfunction Hemorrhage, GU -- Retinal detachment ALLERGY/IMMUNOLOGY Allergic rhinitis (including sneezing, nasal stuffiness, postnasal drip) Infection with unknown ANC -- rhinorrhea ALLERGY/IMMUNOLOGY Allergic rhinitis (including sneezing, nasal stuffiness, rhonchi rickets See: phosphate ridging rigors ringing in ears See: tinnitus ROM RTA rub Adult Respiratory Distress Syndrome (ARDS) Cough Voice changes/dysarthria (e.g., hoarseness, loss or alteration in voice, laryngitis) Nail changes CONSTITUTIONAL SYMPTOMS Rigors/chills Cytokine release syndrome/acute infusion reaction Joint-function Phosphate, serum-low (hypophosphatemia) Urinary electrolyte wasting (e.g., Fanconi's syndrome, renal tubular acidosis) retinopathy - rub 105 of 133

106 -- R -- CARDIAC GENERAL Pericardial effusion (non-malignant) Pericarditis 8 8 runny nose See: rhinitis rupture Urinary retention (including neurogenic bladder) 62 runny nose - rupture 106 of 133

107 -- S -- sacral plexus Intra-operative injury -- sadness schistocytes BLOOD/BONE MARROW saliva Mood alteration -- Dry mouth/salivary gland (xerostomia) Salivary gland changes/saliva Hemolysis (e.g., immune hemolytic anemia, drug-related hemolysis) COAGULATION Thrombotic microangiopathy (e.g., thrombotic thrombocytopenic purpura [TTP] or hemolytic uremic syndrome [HUS]) 4 10 salivary gland Bilirubin (hyperbilirubinemia) 40 Dry mouth/salivary gland (xerostomia) Fistula, GI -- Salivary gland changes/saliva Infection with unknown ANC -- Intra-operative injury schizophrenia Psychosis (hallucinations/delusions) Schwartz-Bartter Syndrome Neuroendocrine: ADH secretion abnormality (e.g., SIADH or low ADH) scleral necrosis Scleral necrosis/melt 54 salt craving Adrenal insufficiency sclero derma ALLERGY/IMMUNOLOGY Autoimmune reaction 1 SAS scalp Leukoencephalopathy (radiographic findings) 49 sclerosis Pneumothorax Prolonged chest tube drainage or air leak after pulmonary resection Hair loss/alopecia (scalp or body) 14 sacral plexus - scoliosis 107 of 133

108 -- S -- scoliosis Bone: spine-scoliosis 43 HEPATOBILIARY/PANCREAS Liver dysfunction/failure (clinical) 34 scrotum Infection with unknown ANC -- Intra-operative injury -- seborrheic keratosis Keratitis (corneal inflammation/corneal ulceration) Second degree block See: atrioventricular rhythm self-esteem senility Sodium, serum-high (hypernatremia) Arachnoiditis/meningismus/radiculitis CNS cerebrovascular ischemia Seizure Confusion Mood alteration -- Personality/behavioral Psychosis (hallucinations/delusions) Confusion Memory impairment Second Malignancy SECONDARY MALIGNANCY seizure Secondary Malignancy - possibly related to cancer treatment (Specify, ) COAGULATION Thrombotic microangiopathy (e.g., thrombotic thrombocytopenic purpura [TTP] or hemolytic uremic syndrome [HUS]) Neuroendocrine: ADH secretion abnormality (e.g., SIADH or low ADH) Hemorrhage, CNS sensory sepsis Myelitis Neuropathy: cranial -- Neuropathy: sensory Intra-operative injury -- HEPATOBILIARY/PANCREAS Cholecystitis Pancreatitis Febrile neutropenia (fever of unknown origin without scoliosis - sepsis 108 of 133

109 -- S -- clinically or microbiologically documented infection)(anc <1.0 x 10e9/L, fever >=38.5 degrees C) Infection with unknown ANC -- Opportunistic infection associated with >=Grade 2 Lymphopenia SEXUAL/REPRODUCTIVE FUNCTION Ejaculatory dysfunction Erectile dysfunction Infertility/sterility Libido Orgasmic dysfunction Vaginal dryness Vaginal mucositis Obstruction, GU -- Stricture/stenosis (including anastomotic), GU SF CARDIAC GENERAL Left ventricular systolic dysfunction 8 septic shock See: sepsis sequestrectomy serologic seroma serum sickness sex Osteonecrosis (avascular necrosis) ALLERGY/IMMUNOLOGY Autoimmune reaction Seroma ALLERGY/IMMUNOLOGY Serum sickness GROWTH AND DEVELOPMENT Puberty (delayed) SGOT SGPT shaking CONSTITUTIONAL SYMPTOMS shock AST, SGOT(serum glutamic oxaloacetic transaminase) ALT, SGPT (serum glutamic pyruvic transaminase) Rigors/chills Pyramidal tract dysfunction (e.g., increased tone, hyperreflexia, positive Babinski, decreased fine motor coordination) Tremor CARDIAC ARRHYTHMIA Conduction abnormality/atrioventricular heart block -- Prolonged QTc interval Supraventricular and nodal arrhythmia -- Ventricular arrhythmia septic shock - shock 109 of 133

110 -- S -- CARDIAC GENERAL short stature shortening fraction See: SF shortness of breath shoulder Hypotension Febrile neutropenia (fever of unknown origin without clinically or microbiologically documented infection)(anc <1.0 x 10e9/L, fever >=38.5 degrees C) Infection with unknown ANC -- Opportunistic infection associated with >=Grade 2 Lymphopenia GROWTH AND DEVELOPMENT Short stature CARDIAC ARRHYTHMIA Palpitations CARDIAC GENERAL Left ventricular diastolic dysfunction Left ventricular systolic dysfunction Adult Respiratory Distress Syndrome (ARDS) Dyspnea (shortness of breath) Hypoxia Pneumothorax Pulmonary fibrosis (radiographic changes) Brachial plexopathy SIADH sicca Sick Sinus Syndrome See: atrioventricular rhythm sight silent aspiration singultus sinus Neuroendocrine: ADH secretion abnormality (e.g., SIADH or low ADH) Ocular surface disease Cataract Glaucoma Vision-blurred vision Vision-flashing lights/floaters Vision-photophobia Aspiration Hiccoughs (hiccups, singultus) CARDIAC ARRHYTHMIA Conduction abnormality/atrioventricular heart block -- Supraventricular and nodal arrhythmia -- Infection with unknown ANC short stature - sinus 110 of 133

111 -- S -- sinusitis sleep Nasal cavity/paranasal sinus reactions Intra-operative injury -- ALLERGY/IMMUNOLOGY Allergic reaction/hypersensitivity (including drug fever) Allergic rhinitis (including sneezing, nasal stuffiness, postnasal drip) CONSTITUTIONAL SYMPTOMS Insomnia Mood alteration -- Cough Hiccoughs (hiccups, singultus) ALLERGY/IMMUNOLOGY sodium Allergic rhinitis (including sneezing, nasal stuffiness, postnasal drip) Incontinence, urinary Sodium, serum-high (hypernatremia) Sodium, serum-low (hyponatremia) soft tissue Infection with unknown ANC -- LYMPHATICS Lymphedema-related fibrosis Soft tissue necrosis slipped capital femoral epiphysis GROWTH AND DEVELOPMENT Bone growth: femoral head; slipped capital femoral epiphysis smell See: CN I CONSTITUTIONAL SYMPTOMS Odor (patient odor) Nasal cavity/paranasal sinus reactions somatotropin Neuroendocrine: growth hormone secretion abnormality GROWTH AND DEVELOPMENT Short stature sneezing Neuropathy: cranial -- somnolence Thyroid function, low (hypothyroidism) 18 sinusitis - somnolence 111 of 133

112 -- S -- spasms Encephalopathy Somnolence/depressed level of consciousness Thyroid function, low (hypothyroidism) Extrapyramidal/involuntary movement/restlessness Cough Bladder spasms sphincter Incontinence, anal Intra-operative injury -- spinal accessory See: CN XI spinal cord Infection with unknown ANC speech AUDITORY/EAR sperm Hearing: patients with/without baseline audiogram and enrolled in a monitoring program Speech impairment (e.g., dysphasia or aphasia) Voice changes/dysarthria (e.g., hoarseness, loss or alteration in voice, laryngitis) Hemorrhage, GU -- Leak (including anastomotic), GU -- Obstruction, GU -- Perforation, GU -- Stricture/stenosis (including anastomotic), GU -- SEXUAL/REPRODUCTIVE FUNCTION Infertility/sterility spine GROWTH AND DEVELOPMENT spleen Arachnoiditis/meningismus/radiculitis Ataxia (incoordination) Myelitis Intra-operative injury -- Bone growth: spine kyphosis/lordosis Bone: spine-scoliosis Cervical spine-range of motion Lumbar spine-range of motion BLOOD/BONE MARROW Splenic function spasms - spleen 112 of 133

113 -- S -- splenectomy BLOOD/BONE MARROW splenomegaly ALLERGY/IMMUNOLOGY VASCULAR ST-wave CARDIAC GENERAL stasis LYMPHATICS stature Infection with unknown ANC -- Intra-operative injury -- Hemolysis (e.g., immune hemolytic anemia, drug-related hemolysis) Intra-operative injury -- Serum sickness Portal vein flow Cardiac ischemia/infarction Dermal change lymphedema, phlebolymphedema GROWTH AND DEVELOPMENT Short stature status epilepticus See: seizure steapsin See: lipase steatorrhea HEPATOBILIARY/PANCREAS stenosis ALLERGY/IMMUNOLOGY AUDITORY/EAR CARDIAC GENERAL SEXUAL/REPRODUCTIVE FUNCTION stent Pancreas, exocrine enzyme deficiency Pancreatitis Allergic rhinitis (including sneezing, nasal stuffiness, postnasal drip) Otitis, external ear (non-infectious) Valvular heart disease Obstruction, GI -- Prolapse of stoma, GI Stricture/stenosis (including anastomotic), GI -- Eyelid dysfunction Nasal cavity/paranasal sinus reactions Obstruction/stenosis of airway -- Prolapse of stoma, GU Stricture/stenosis (including anastomotic), GU -- Vaginal stenosis/length Infection with unknown ANC splenectomy - stent 113 of 133

114 -- S -- Atelectasis Fistula, pulmonary/upper respiratory -- Obstruction/stenosis of airway Lumbar spine-range of motion Stokes-Adams See: atrioventricular rhythm 44 sterile Obstruction, GU -- Stricture/stenosis (including anastomotic), GU -- SEXUAL/REPRODUCTIVE FUNCTION sternomastoid See: CN XI steroids Infertility/sterility Neuropathy: cranial -- ALLERGY/IMMUNOLOGY Vasculitis BLOOD/BONE MARROW Hemolysis (e.g., immune hemolytic anemia, drug-related hemolysis) Obstruction/stenosis of airway stoma Leak (including anastomotic), GI -- Necrosis, GI -- Obstruction, GI -- Prolapse of stoma, GI Stricture/stenosis (including anastomotic), GI -- Ulcer, GI -- Hemorrhage, GI -- Hemorrhage, GU -- Hemorrhage, pulmonary/upper respiratory -- Leak (including anastomotic), GU -- Obstruction, GU -- Perforation, GU -- Prolapse of stoma, GU Stricture/stenosis (including anastomotic), GU -- Intra-operative injury Stevens-Johnson Syndrome stiffness "Retinoic acid syndrome" Rash: erythema multiforme (e.g., Stevens-Johnson syndrome, toxic epidermal necrolysis) Joint-function stomach Fistula, GI -- Leak (including anastomotic), GI -- Mucositis/stomatitis (clinical exam) -- Mucositis/stomatitis (functional/symptomatic) -- Nausea Necrosis, GI -- Obstruction, GI -- Perforation, GI sterile - stomach 114 of 133

115 -- S -- stomatitis stool Stricture/stenosis (including anastomotic), GI -- Ulcer, GI -- Vomiting Hemorrhage, GI -- Infection with unknown ANC -- Intra-operative injury -- Rash: erythema multiforme (e.g., Stevens-Johnson syndrome, toxic epidermal necrolysis) Mucositis/stomatitis (clinical exam) -- Mucositis/stomatitis (functional/symptomatic) -- Salivary gland changes/saliva Colitis Constipation Diarrhea Enteritis (inflammation of the small bowel) Incontinence, anal Proctitis Typhlitis (cecal inflammation) HEPATOBILIARY/PANCREAS storm See: thyroid storm strabismus stretch marks See: striae striae stricture Pancreas, exocrine enzyme deficiency Colitis, infectious (e.g., Clostridium difficile) Thyroid function, high (hyperthyroidism, thyrotoxicosis) Neuropathy: cranial -- Striae Cushingoid appearance (e.g., moon face, buffalo hump, centripetal obesity, cutaneous striae) Obstruction, GI -- Stricture/stenosis (including anastomotic), GI -- Stricture/stenosis (including anastomotic), GU -- stricture/stenosis (including anastomotic) Dysphagia (difficulty swallowing) Obstruction, GI -- Prolapse of stoma, GI Stricture/stenosis (including anastomotic), GI stomatitis - stricture/stenosis (including anastomotic) 1 of 133

116 -- S -- stupor HEPATOBILIARY/PANCREAS stridor Prolapse of stoma, GU Stricture/stenosis (including anastomotic), GU -- Urinary retention (including neurogenic bladder) Liver dysfunction/failure (clinical) Arachnoiditis/meningismus/radiculitis Somnolence/depressed level of consciousness stroke Edema, larynx Obstruction/stenosis of airway -- Voice changes/dysarthria (e.g., hoarseness, loss or alteration in voice, laryngitis) COAGULATION Thrombotic microangiopathy (e.g., thrombotic thrombocytopenic purpura [TTP] or hemolytic uremic syndrome [HUS]) Hemorrhage, CNS CNS cerebrovascular ischemia Syncope (fainting) subarachnoid subdural Hemorrhage, CNS Arachnoiditis/meningismus/radiculitis Leukoencephalopathy (radiographic findings) Hemorrhage, CNS sublingual Salivary gland changes/saliva substernal pain VASCULAR CARDIAC GENERAL Vessel injury-artery Cardiac ischemia/infarction 7 stuffiness ALLERGY/IMMUNOLOGY Allergic rhinitis (including sneezing, nasal stuffiness, postnasal drip) 1 Heartburn/dyspepsia 22 stumbling Extremity-lower (gait/walking) 43 sudden death DEATH Death not associated with CTCAE term Ataxia (incoordination) sufficient AUDITORY/EAR stridor - sufficient 116 of 133

117 -- S -- Hearing: patients with/without baseline audiogram and enrolled in a monitoring program suicidal ideation sunburn Mood alteration -- Photosensitivity 2 49 swelling Hot flashes/flushes Cytokine release syndrome/acute infusion reaction Injection site reaction/extravasation changes Distension/bloating, abdominal supraventricular and nodal arrhythmia CARDIAC ARRHYTHMIA SVC VASCULAR SVT See: supraventricular and nodal arrhythmia swallowing sweating Supraventricular and nodal arrhythmia -- Vessel injury-vein -- Dysphagia (difficulty swallowing) Esophagitis Mucositis/stomatitis (functional/symptomatic) -- Neuropathy: cranial -- Aspiration CONSTITUTIONAL SYMPTOMS Sweating (diaphoresis) LYMPHATICS Dermal change lymphedema, phlebolymphedema Edema: limb Edema: trunk/genital Edema: viscera Lymphocele symblepharon syncope Arthritis (non-septic) Eyelid dysfunction ALLERGY/IMMUNOLOGY Autoimmune reaction CARDIAC ARRHYTHMIA Conduction abnormality/atrioventricular heart block -- Prolonged QTc interval Supraventricular and nodal arrhythmia -- Vasovagal episode Ventricular arrhythmia suicidal ideation - syncope 1 of 133

118 -- S -- Adrenal insufficiency Hemorrhage, CNS CNS cerebrovascular ischemia Dizziness Syncope (fainting) systolic Flu-like syndrome Thrombotic microangiopathy Tumor flare Tumor lysis syndrome CARDIAC GENERAL Left ventricular systolic dysfunction syndrome CARDIAC ARRHYTHMIA Conduction abnormality/atrioventricular heart block -- 5 COAGULATION Thrombotic microangiopathy (e.g., thrombotic thrombocytopenic purpura [TTP] or hemolytic uremic syndrome [HUS]) 10 Rash: erythema multiforme (e.g., Stevens-Johnson syndrome, toxic epidermal necrolysis) Neuroendocrine: ADH secretion abnormality (e.g., SIADH or low ADH) Proteinuria 42 Dry eye syndrome Adult Respiratory Distress Syndrome (ARDS) 56 Urinary electrolyte wasting (e.g., Fanconi's syndrome, renal tubular acidosis) 62 "Retinoic acid syndrome" Alcohol intolerance syndrome (antabuse-like syndrome) Cytokine release syndrome/acute infusion reaction syndrome - systolic 118 of 133

119 -- T -- t-score T-wave Osteoporosis CARDIAC GENERAL Cardiac ischemia/infarction Potassium, serum-high (hyperkalemia) tachycardia CARDIAC ARRHYTHMIA Supraventricular and nodal arrhythmia -- Ventricular arrhythmia -- Cytokine release syndrome/acute infusion reaction taste See: CN VI, CN IX tearing Puberty (delayed) Salivary gland changes/saliva Taste alteration (dysgeusia) Neuropathy: cranial -- Intra-operative injury -- Watery eye (epiphora, tearing) tachypnea talk CARDIAC GENERAL Left ventricular diastolic dysfunction Left ventricular systolic dysfunction Adult Respiratory Distress Syndrome (ARDS) Cough Pneumothorax Pulmonary fibrosis (radiographic changes) Speech impairment (e.g., dysphasia or aphasia) tamponade CARDIAC GENERAL Pericardial effusion (non-malignant) Tanner Stage GROWTH AND DEVELOPMENT teeth Dental: teeth development Dental: teeth Intra-operative injury -- telangiectasia Telangiectasia Eyelid dysfunction temperature CONSTITUTIONAL SYMPTOMS t-score - temperature 119 of 133

120 -- T -- Fever (in the absence of neutropenia, where neutropenia is defined as ANC <1.0 x 10e9/L) Febrile neutropenia (fever of unknown origin without clinically or microbiologically documented infection)(anc <1.0 x 10e9/L, fever >=38.5 degrees C) 11 tethering Renal failure LYMPHATICS Lymphedema-related fibrosis TEN See: Stevens-Johnson Syndrome Fibrosis-deep connective tissue 44 tenesmus testes Proctitis GROWTH AND DEVELOPMENT Puberty (delayed) Third degree block See: atrioventricular rhythm thirst Dehydration Dry mouth/salivary gland (xerostomia) tetany Hemorrhage, GU -- Obstruction, GU -- Perforation, GU -- Stricture/stenosis (including anastomotic), GU -- Parathyroid function, low (hypoparathyroidism) Calcium, serum-low (hypocalcemia) Magnesium, serum-low (hypomagnesemia) Phosphate, serum-low (hypophosphatemia) Trismus (difficulty, restriction or pain when opening mouth) thombolysis Hemorrhage, CNS thoracentesis Chylothorax Pleural effusion (non-malignant) thoracostomy Fistula, pulmonary/upper respiratory -- Prolonged chest tube drainage or air leak after pulmonary resection thought processes Mood alteration -- threshold shift TEN - threshold shift 120 of 133

121 -- T -- AUDITORY/EAR thrombocytopenia thromboplastin thrombosis thyroid Hearing: patients with/without baseline audiogram and enrolled in a monitoring program BLOOD/BONE MARROW Platelets COAGULATION Thrombotic microangiopathy (e.g., thrombotic thrombocytopenic purpura [TTP] or hemolytic uremic syndrome [HUS]) Bruising (in absence of Grade 3 or 4 thrombocytopenia) COAGULATION PTT (Partial Thromboplastin Time) COAGULATION Thrombotic microangiopathy (e.g., thrombotic thrombocytopenic purpura [TTP] or hemolytic uremic syndrome [HUS]) VASCULAR Phlebitis (including superficial thrombosis) Thrombosis/embolism (vascular access-related) Thrombosis/thrombus/embolism ALLERGY/IMMUNOLOGY Autoimmune reaction Adrenal insufficiency Thyroid function, high (hyperthyroidism, thyrotoxicosis) Thyroid function, low (hypothyroidism) thyroid storm thyroplasty thyrotoxicosis thyroxin TIA tidal volume See: FEV1 tingling tinnitus Intra-operative injury -- Thyroid function, high (hyperthyroidism, thyrotoxicosis) Laryngeal nerve dysfunction Thyroid function, high (hyperthyroidism, thyrotoxicosis) Thyroid function, high (hyperthyroidism, thyrotoxicosis) CNS cerebrovascular ischemia Syncope (fainting) Neuropathy: cranial -- Neuropathy: sensory AUDITORY/EAR Tinnitus Dizziness thrombocytopenia - tired 121 of 133

122 -- T -- tired CONSTITUTIONAL SYMPTOMS Fatigue (asthenia, lethargy, malaise) 11 torticollis Extrapyramidal/involuntary movement/restlessness TMJ Todd's paralysis toenails Seizure Nail changes tongue See: CN IX, CN XII Neuropathy: cranial trachea Mucositis/stomatitis (clinical exam) -- Mucositis/stomatitis (functional/symptomatic) -- Hemorrhage, pulmonary/upper respiratory -- Infection with unknown ANC -- Fistula, pulmonary/upper respiratory -- Obstruction/stenosis of airway Intra-operative injury -- Intra-operative injury -- tonic See: seizure tooth See: teeth toothache Torsade de pointes CARDIAC ARRHYTHMIA Prolonged QTc interval Ventricular arrhythmia tracheo-esophageal Fistula, GI -- Fistula, pulmonary/upper respiratory -- tracheotomy LYMPHATICS Edema: head and neck Laryngeal nerve dysfunction tired - tracheotomy 122 of 133

123 -- T -- Edema, larynx Obstruction/stenosis of airway -- Prolonged intubation after pulmonary resection (>24 hrs after surgery) transaminase See: ALT, AST ALT, SGPT (serum glutamic pyruvic transaminase) AST, SGOT(serum glutamic oxaloacetic transaminase) transfusion BLOOD/BONE MARROW Hemolysis (e.g., immune hemolytic anemia, drug-related hemolysis) Hematoma Hemorrhage, CNS Hemorrhage, GI -- Hemorrhage, GU -- Hemorrhage, pulmonary/upper respiratory -- Hemorrhage/bleeding associated with surgery, intraoperative or postoperative Petechiae/purpura (hemorrhage/bleeding into skin or mucosa) Cystitis transient See: TIA transudate trapezius See: CN XI tremor tresis Glomerular filtration rate Renal failure Pleural effusion (non-malignant) Magnesium, serum-low (hypomagnesemia) Extrapyramidal/involuntary movement/restlessness Pyramidal tract dysfunction (e.g., increased tone, hyperreflexia, positive Babinski, decreased fine motor coordination) Tremor Perforation, GI -- trichiasis Eyelid dysfunction transplant CARDIAC GENERAL Left ventricular diastolic dysfunction Left ventricular systolic dysfunction Restrictive cardiomyopathy Right ventricular dysfunction (cor pulmonale) trichoma See: trichiasis trigeminal See: CN V trigeminy transaminase - trigeminy 123 of 133

124 -- T -- triglyceride trismus trochlear See: CN IV troponin See: cardiac troponin TSH TTP CARDIAC ARRHYTHMIA tumor Ventricular arrhythmia -- Lipase Triglyceride, serum-high (hypertriglyceridemia) Calcium, serum-low (hypocalcemia) Trismus (difficulty, restriction or pain when opening mouth) Thyroid function, low (hypothyroidism) COAGULATION Thrombotic microangiopathy (e.g., thrombotic thrombocytopenic purpura [TTP] or hemolytic uremic syndrome [HUS]) Thrombotic microangiopathy turgor LYMPHATICS TURP tympanic membrane AUDITORY/EAR tympanostomy AUDITORY/EAR tympany typhlitis (Specify, ) Cytokine release syndrome/acute infusion reaction Tumor flare Tumor lysis syndrome Dehydration Dermal change lymphedema, phlebolymphedema Lymphedema-related fibrosis Urinary retention (including neurogenic bladder) Otitis, external ear (non-infectious) Otitis, external ear (non-infectious) Distension/bloating, abdominal Typhlitis (cecal inflammation) SECONDARY MALIGNANCY Secondary Malignancy - possibly related to cancer treatment 63 triglyceride - typhlitis 124 of 133

125 -- U -- ulcer Skin breakdown/decubitus ulcer 16 Infection with unknown ANC -- Distension/bloating, abdominal Gastritis (including bile reflux gastritis) Mucositis/stomatitis (clinical exam) -- Mucositis/stomatitis (functional/symptomatic) -- Ulcer, GI uremic COAGULATION Thrombotic microangiopathy (e.g., thrombotic thrombocytopenic purpura [TTP] or hemolytic uremic syndrome [HUS]) 10 ulceration Renal failure 61 Injection site reaction/extravasation changes Rash: acne/acneiform Rash: dermatitis associated with radiation -- Rash: erythema multiforme (e.g., Stevens-Johnson syndrome, toxic epidermal necrolysis) Ulceration Dysphagia (difficulty swallowing) Mucositis/stomatitis (clinical exam) -- Ulcer, GI uremic frost urgency Renal failure Diarrhea Urinary frequency/urgency LYMPHATICS SEXUAL/REPRODUCTIVE FUNCTION ungual Dermal change lymphedema, phlebolymphedema Edema: head and neck Keratitis (corneal inflammation/corneal ulceration) Vaginal mucositis Vaginitis (not due to infection) uric acid urinary Uric acid, serum-high (hyperuricemia) Hemorrhage, GU -- Infection with unknown ANC ulcer - urinary 125 of 133

126 -- U -- Fistula, GU -- Incontinence, urinary Urinary electrolyte wasting (e.g., Fanconi's syndrome, renal tubular acidosis) Urinary frequency/urgency Urinary retention (including neurogenic bladder) Urine color change uveitis Perforation, GU -- Stricture/stenosis (including anastomotic), GU -- Intra-operative injury -- Uveitis Intra-operative injury -- urticaria ALLERGY/IMMUNOLOGY Allergic reaction/hypersensitivity (including drug fever) 1 Urticaria (hives, welts, wheals) 16 Cytokine release syndrome/acute infusion reaction 68 uterus Hemorrhage, GU -- Infection with unknown ANC -- Fistula, GU -- Leak (including anastomotic), GU -- Obstruction, GU urticaria - uveitis 126 of 133

127 -- V -- vagina Hemorrhage, GU -- Hemorrhoids 22 SEXUAL/REPRODUCTIVE FUNCTION vaginitis See: vagina Vagus See: CN X valve CARDIAC GENERAL varices Infection with unknown ANC -- Fistula, GU -- Leak (including anastomotic), GU -- Obstruction, GU -- Perforation, GU -- Stricture/stenosis (including anastomotic), GU -- Vaginal discharge (non-infectious) Vaginal dryness Vaginal mucositis Vaginal stenosis/length Vaginitis (not due to infection) Intra-operative injury -- Valvular heart disease vas deferens vasculitis vasomotor vasopressin vasovagal vein Hemorrhage, GI -- Hemorrhage, GU -- Leak (including anastomotic), GU -- Obstruction, GU -- Perforation, GU -- Stricture/stenosis (including anastomotic), GU -- ALLERGY/IMMUNOLOGY Vasculitis Rash: hand-foot skin reaction Hot flashes/flushes Neuroendocrine: ADH secretion abnormality (e.g., SIADH or low ADH) CARDIAC ARRHYTHMIA Vasovagal episode vagina - vein 127 of 133

128 -- V -- ventilation ventriculostomy vertigo Infection with unknown ANC -- LYMPHATICS Phlebolymphatic cording Intra-operative injury -- VASCULAR Portal vein flow Thrombosis/embolism (vascular access-related) Thrombosis/thrombus/embolism Vessel injury to a vein intra-operatively Phrenic nerve dysfunction Chylothorax FEV(1) Hypoxia Pleural effusion (non-malignant) Pneumonitis/pulmonary infiltrates Pneumothorax "Retinoic acid syndrome" Cytokine release syndrome/acute infusion reaction VASCULAR Acute vascular leak syndrome Hemorrhage, CNS See: dizziness vesicular vestibulocochlear See: CN VIII viral hepatitis virilism viscera Rash/desquamation Viral hepatitis Masculinization of female LYMPHATICS Edema: viscera Intra-operative injury -- VASCULAR Vessel injury-artery -- Vessel injury-vein -- Visceral arterial ischemia (non-myocardial) vision See: CN II Neuropathy: cranial -- Cataract Dry eye syndrome Eyelid dysfunction ventilation - vision 128 of 133

129 -- V -- See: CN II Glaucoma Keratitis (corneal inflammation/corneal ulceration) Night blindness (nyctalopia) Nystagmus Ocular surface disease Ophthalmoplegia/diplopia (double vision) Optic disc edema Proptosis/enophthalmos Retinal detachment Retinopathy Scleral necrosis/melt Uveitis Vision-blurred vision Vision-flashing lights/floaters Vision-photophobia Vitreous hemorrhage Watery eye (epiphora, tearing) vocal cord VOD voice vomiting Laryngeal nerve dysfunction CONSTITUTIONAL SYMPTOMS Weight gain VASCULAR Portal vein flow Speech impairment (e.g., dysphasia or aphasia) Voice changes/dysarthria (e.g., hoarseness, loss or alteration in voice, laryngitis) vital Adrenal insufficiency vitiligo Vital capacity Hypopigmentation Adrenal insufficiency Dehydration Ileus, GI (functional obstruction of bowel, i.e., neuroconstipation) Nausea Obstruction, GI -- Stricture/stenosis (including anastomotic), GI -- Ulcer, GI -- Vomiting vitrectomy Arachnoiditis/meningismus/radiculitis Vitreous hemorrhage 54 vitreous Cytokine release syndrome/acute infusion reaction 68 Vitreous hemorrhage 54 vulva vital - vulva 129 of 133

130 -- V -- Infection with unknown ANC -- Intra-operative injury -- vital - vulva 130 of 133

131 -- W -- wakefulness weight CONSTITUTIONAL SYMPTOMS CONSTITUTIONAL SYMPTOMS walk Insomnia Extremity-lower (gait/walking) Neuropathy: motor Obesity Weight gain Weight loss Adrenal insufficiency Thyroid function, low (hypothyroidism) watery eye Watery eye (epiphora, tearing) 54 Anorexia Malabsorption Nausea Vomiting WBC BLOOD/BONE MARROW Leukocytes (total WBC) 4 HEPATOBILIARY/PANCREAS Pancreas, exocrine enzyme deficiency 34 weakness "Retinoic acid syndrome" 69 Adrenal insufficiency Malabsorption Sodium, serum-low (hyponatremia) Extremity-lower (gait/walking) Muscle weakness, generalized or specific area (not due to neuropathy) -- Laryngeal nerve dysfunction Myelitis Neuropathy: motor Neuropathy: sensory Phrenic nerve dysfunction welts Wenckebach CARDIAC ARRHYTHMIA wheals Urticaria (hives, welts, wheals) Cytokine release syndrome/acute infusion reaction Conduction abnormality/atrioventricular heart block -- Urticaria (hives, welts, wheals) Cytokine release syndrome/acute infusion reaction wheezing wakefulness - wheezing 131 of 133

132 -- W -- ALLERGY/IMMUNOLOGY Allergic reaction/hypersensitivity (including drug fever) Bronchospasm, wheezing WNL CARDIAC GENERAL Hypertension Wolff-Parkinson-White See: atrioventricular rhythm wound WPW Skin breakdown/decubitus ulcer Ulceration Wound complication, non-infectious Hematoma Infection with unknown ANC -- Fracture Local complication -device/prosthesis-related Soft tissue necrosis -- CARDIAC ARRHYTHMIA Conduction abnormality/atrioventricular heart block WNL - WPW 1 of 133

133 -- X -- xerostomia Dry mouth/salivary gland (xerostomia) Salivary gland changes/saliva xerostomia - xerostomia 133 of 133