x = ( A) + (3.296 B) (0.070 C) (1.006 D) + (2.426 E) Receiver Operating Characteristic ROC

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3 Glasgow outcome scale GOS GOS 4 n= A C D 5 ph B E = 1/(1 + e x) x = ( 0.0 A) + (.96 B) (0.070 C) (1.006 D) + (.46 E) estimated probability n=01 5 Receiver Operating Characteristic ROC 80% 9% 90%. 1- extracorporeal cardiopulmonary resuscitation 4 ECPR 1

4 interleukin IL -6 IL-85 6 NSE6 7 glial fibrillary acidic protein GFAP S100b BB10 computed tomography CT magnetic resonance imaging MRI

5 CPR cardiopulmonary resuscitation ph 6 16 GOS 4 GOS 1- CPR 1 dead vegetative state severe disability 4 moderate disability 5 good recovery 5

6 U P 17 Sidak P < 0.01 =0 =1 =1 =0 CPR =0 =0 = 1; =1 =1 =0 =0 =1 =0 area under the curve AUC ROC 6 4 =1

7 n = 488) n = 6) ( n = 5) (n = 477) (n = 55) (n = 4) n = 1) n = 7) ( n = 5) (n = 01) (n = 5) (n = 176) 1 5

8 CPR a P-valueb (n = 477) (n = 01) 64 ± 0 7 ± 16 < (67) 104 (5) < (46) 9 (46) (59) 1 (66) (7) 76 (8) < (18) 6 (18) ± 15 1 ± 15 < 0.01 ± 19 0 ± (1) 9 (14) (8) 6 () (8) 1 (6) ± ± ± ± (1) 5 (1) 0.74 CPR mm ph a a b CPR cardiopulmonary resuscitation 6 P < 0.01

9 good recovery 5 moderate disability vegetative state 79 4 severe disability dead 40 A C E ph B D 5 X A~E = 1/(1 + e x) x = ( 0.0 A) + (.96 B) (0.070 C) (1.006 D) + (.46 E) A C D B E ph P mm a ph 0.1 a 7

10 AUC ROC % 94% 9% ROC 8 4

11 % 90% ROC 0.18 AUC 80% 0.94 AUC ROC 9

12 Hayakawa 18 80% 9% 11 5 ph Hayakawa 18 1 Fisher CPR 19-4 Wijdicks % 1 HACA study 15% 10

13 Limitation limitation % 11 1

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