CLINICAL CHARACTERISTICS AND OUTCOME OF HEART TRANSPLANT IN ADULTS WITH CONGENITAL HEART DISEASES
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1 CLINICAL CHARACTERISTICS AND OUTCOME OF HEART TRANSPLANT IN ADULTS WITH CONGENITAL HEART DISEASES
2 Subanalysis Spanish Registry on Heart TransplantaCon ( ) Authors: Dimpna C. Albert 1 María J. Paniagua 2, Luis Almenar 3,, Vicenç Brossa 4, Marisa G. Crespo 2, Javier Segovia 5, Jesús Palomo 6, Juan Delgado 7, Francisco González Vílchez 8, Nicolás Manito 9, Ernesto Lage 10, Luis García Guereta 11, José L. Rodríguez Lambert 12. (1)Vall d'hebron Hospital. Barcelona. (2) Hospital University of A Coruña. A Coruña (3)Director of Spanish Registry on Heart TransplantaGn. University Hospital La Fe. Valencia. (4)Hospital Santa Cruz y San Pablo. Barcelona. (5)Clinica Puerta de Hierro Majadahonda. Madrid. (6)Gregorio Marañón Hospital. Madrid (Adultos). (7)Hospital 12 de Octubre. Madrid. (8)Marqués de Valdecilla Hospital. Santander. (9)Bellvitge Hospital. Barcelona. (10)Virgen del Rocío Hospital. Sevilla. (11)La Paz Hospital. Madrid. (12)Asturias Central Hospital. Oviedo.
3 Congenital heart diseases (CHD) are structural defects in the heart with high infant mortality rates, but thanks to recent medical and surgical advances, these pacents now reach adulthood. In spite of medical and surgical advances some pacents affected by CHD need a heart trasplant as adults. It has become necessary to analyze clinical characterisccs of these Htx candidates
4 ObjecCve: To analyze outcome in Spanish adult transplanted populacon with CHD (different subgroups) and compare it with the most frequent causes of adult transplantacon: Ischemic Heart Disease [IHD] Idiopathic Dilated Cardiomyopathy [IDCM]
5 Material and Methods From May 1984 Dec 2009 Total HTx 6048 pacents Excluded: Pediatric transplants(<16 years), combined transplants, rehtx, HTx performed in other centers without adult CHD cases, and HTx for heart diseases other than IDCM and IHD Study populacon: 3166 pacents: IHD 1.888; IDCM 1223: CHD 55
6 Material and Methods Htx Nº: Htx < 16 años Nº: 239 HTx without CHD (excluded) Nº: Heart-Lung Tx: 56 Renal+Cardiac Tx : 46 Liver+Cardiac Tx: 7 ReHtx: 153 HTx for other heart diseases Nº: Ischemic Heart Diseases (IHD) Nº: Idiopathic Dilated Cardiomyopathy (IDCM) Nº: Nº Adult Congenital Heart Disease (CHD) Nº: 55
7 Material and Methods Study subgroups: CHD transplants were classified according to pathophysiology into 4 groups: 1) Single ventricle with different degrees of pulmonary Stenosis (n:18) 2) Single ventricle with Cavopulmonary shunt surgery (Glenn/Fontan procedure) (n:10) 3) Congenitally corrected transposicon of great arteries or DTG with atrial Switch (Mustard/Senning surgery) (n:10). 4) CHDs with different degrees of right ventricle overload Tetralogy of Fallot, Ebstein's disease, DTG with PS and Rastelli patch, DORV) (n:17).
8 Results Significant differences were found between the clinical profile of pacents with CHD and other groups: younger age, less need for inotropes and minor renal dysfunccon, with less risks factors
9 Results Probability survival Years for first Trasplant The analysis of survival showed some differences among groups (CHD vs IHD, p=0.05; CHD vs IDCM, p=0.5; IHD vs IDCM, p=0.0001) The probability of overall survival was higher in CHD group, despite its high early mortality.
10 Results Probability survival Group 1: SV + PS Group 2: SV + Glenn/ Fontan surgery Group 3: RV systemic (CTGA/ Senning) Group 4: CHDs overload RV Years for first Trasplant Early mortality was different between the different CHD subgroups (group 1: 19%, group 2: 40%, group 3: 0%, group 4: 29%; p<0.001) No significant differences among subgroups were found in long term survival
11 Summary Percentage of adult with CHD transplanted in Spain is low (1%). Long term survival is higher compared with groups with different indicacons for HTx (IHD and IDCM). Early mortality is high in operated or unoperated pacents with single ventricle physiology. European registries with a larger number of pacents are needed to beqer define results in this group of pacents.
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