Management of cervicocephalic arterial dissection. Ciro G. Randazzo, MD, MPH Thomas Jefferson University Hospital, Department of Neurosurgery

Transcription

1 Management of cervicocephalic arterial dissection Ciro G. Randazzo, MD, MPH Thomas Jefferson University Hospital, Department of Neurosurgery

2 Definition Disruption of arterial wall, either at level of intima-media media or media-adventitia, adventitia, due to hemorrhage within wall

3 Presentation Classical triad for extracranial ICA dissection 1. Ipsilateral headache 2. Facial or neck pain 3. Partial Horner s s syndrome (Miosis and ptosis only because interrupt postganglionic sympathetic fibers) CVA especially in the young or after trauma; CVA can be seen in up to 40-60% of patients w/dissection TIA Local compressive syndromes, e.g. IX, X, XII SAH most commonly with intracranial vertebral artery dissection

4 Epidemiology Responsible for % of all stroke, particularly in patients <40 yrs old Average incidence of dissection 2-33 per 100,000 population (ICA) per 100,000 population (vertebral) Stroke incidence due to dissection Infarct % TIA % (Schievink et al 1994) Recurrent stroke after dissection ~1% per year, thought to decrease rapidly

5 Etiology Spontaneous Traumatic, e.g. blunt carotid injury, penetrating injury Connective Tissue Disorder, e.g. Marfan s, Ehrlos Danlos Type IV, FMD, ADPCKD, OI Type I, Cystic medial necrosis Chiropractic Manipulation

6 Pathophysiology Intimal tear Mural hematoma Stenosis from formation of mural hematoma at level of intima-media media Pseudoaneurysm from formation of mural hematoma at level media-adventitia adventitia

7 Pathophysiology of morbidities due Horner s s syndrome to dissection Ptosis and miosis from interruption of postganglionic sympathetic fibers traveling on internal carotid artery SAH Pseudoaneurysm rupture intracranial dissection with bleeding and hematoma formation at media- adventitia interface leads to bleeding into subarachnoid space CVA/TIA Hemodynamic compromise from stenosis vs. microemboli? Implications for treatment!

8 Radiographic findings Stenosis irregular, seen in areas not prone to stenosis from atherosclerosis, e.g. distal to carotid bifurcation String sign Occlusion Pseudoaneurysm - fusiform Crescent/Egg yolk narrowed, eccentric flow void surrounded by hyperintense, crescentic signal Double lumen Intimal flap Mural hematoma

9 Radiographic findings stenosis, string sign

10 Radiographic findings CVA, occlusion

11 Radiographic findings - Crescent/Egg yolk

12 Radiographic findings SAH, pseudoaneurysm

13 Treatment Do nothing Secondary stroke prevention with anticoagulation debate as to choice of anticoagulant Thrombolysis for occlusion Arterial reconstruction/repair via open surgery, stenting and/or coiling of stenosis or flap or pseudoaneurysm

14 Argument in favor of anticoagulation Dissection responsible for significant amount of stroke, particularly in young population Stroke from dissection has been associated with death Dissection and stroke can recur after initial dissection Most dissections/occlusions recanalize

15 Arguments against anticoagulation Anticoagulation in acute stroke can increase the rate of symptomatic hemorrhagic transformation Dissections can propagate/involve intracranial vessels which can lead to SAH which is a contraindication to anticoagulation Anticoagulation can favor expansion of mural hematoma Recurrence rate of stroke after dissection is low (<1% per year) and spontaneous recanalization rate is high

16 Arguments in favor of heparinization and warfarin Transcranial doppler has shown increased frequency of high-intensity intensity transient signals (HITS) in patients with recurrent strokes/tias Most strokes from dissection are cortical and subcortical as opposed to watershed Distal branch emboli have been found in dissection associated stroke Analogous to risk of embolus from Afib being reduced with warfarin > with antiplatelets, coumadin would be the preferred means of anticoagulation

17 Arguments in favor of antiplatelets Hyperacute anticoagulation in acute stroke can increase the rate of symptomatic hemorrhagic transformation Increased anticoagulant effect of heparin/warfarin may allow expansion of intramural hematoma CARESS trial showed reduced HITs with ASA and plavix Ease of administration, e.g. no blood testing required Lower risk for bleeding complications

18 Studies comparing anticoagulants in cervicocephalic dissection There is NO level I evidence supporting the use of warfarin or antiplatelets in cervicocephalic dissection

19 Studies comparing anticoagulants in cervicocephalic dissection Wahl, et al Journal of Trauma, 2002 Retrospective review of 22 cases of blunt carotid injury with dissection No difference in neurological outcome observed between pts receiving warfarin vs. antiplatelets Canadian Stroke Consortium Stroke, patient series Annual recurrence rate for CVA, TIA, or death was higher in ASA group than with warfarin group, but not statistically significant Arauz, et al Cerebrovasc Dis, patient series No significant differences found in recurrent ischemic stroke in patients receiving aspirin vs. warfarin

20 Studies comparing anticoagulants in cervicocephalic dissection Edwards, et al Journal of the American College of Surgeons, 2007 Retrospective review of 110 patients No difference in functional outcome in patients receiving warfarin or antiplatelets Engelter, et al Stroke, 2007 ; also published as Cochrane Review No reliable comparisons of antiplatelets or anticoagulants with control were available Meta-analysis analysis of 26 studies with 327 patients The likelihood of death did not differ between warfarin and antiplatelet groups The likelihood of being dead or disabled did not differ between warfarin and antiplatelet groups

21 Conclusion Dissection remains a significant cause of morbidity and mortality in a young population Strategies for stroke prevention in dissection remain empiric rather than evidence based The exact pathophysiology of stroke after dissection remains unclear A randomized, case-controlled controlled study of anticoagulation with coumadin vs.. antiplatelet agents is 1. Necessary 2. Warranted, and 3. Ethical

22 Bibliography