Preliminary Scientific Program 23/2/2017

Transcription

1 Preliminary Scientific Program 23/2/2017 Sunday, December 3, 2017 ICI Academy of Innovation Day Developing New Cardiovascular Therapies; The Innovation Process and the Role of a Key Opinion Leader 07:30-07:40 07:40-08:00 08:00-08:20 08:20-08:30 08:30-08:50 08:50-09:10 09:10-09:30 09:30-10:00 10:00-10:40 10:40-11:10 11:10-11:30 11:30-11:50 11:50-12:10 12:10-12:50 Registration and Breakfast Welcomes: Prof. Chaim Lotan, MD Prof. Rafi Beyar, MD Dr. Martin T. Rothman, MD Workshop Introduction: Prof. Paul A. Iaizzo, PhD Re-Shaping Medical Pipelines - How Clinicians are Becoming Innovators Prof. Chaim Lotan Perspective on Innovation Development Within an Academic Medical Center Prof. Rafi Beyar How New Medical Products are Developed - Overview of New Product Development Process Prof. William Durfee Essentials of Creativity - Sketching, Notebooks and Documenting Prof. Paul Iaizzo and Prof. William Durfee Brainstorming Warmup Prof. William Durfee Testing Your Medical Device Idea: Bench Tests, Pre-Clinical, Clinical Trials Prof. Paul Iaizzo Innovation Exercise 1: Generate Ideas Coffee and Networking Break Protecting Your Intellectual Property Through Patents Prof. William Durfee Device Innovation: Role of Regulatory Requirements in the US Dr. Semih Oktay Inventing, Developing and Commercializing New Medical Devices Mr. Xavier E. Pardo Lunch

2 12:50-13:10 13:10-13:40 13:40-14:40 14:40-15:00 15:00-15:20 15:20-15:50 15:50-16:20 16:20-17:00 How to Determine if a New Device is Needed - Market Evaluation and Needs Assessment Methods Dr. Todd J. Brinton From Clever Engineering to Corporate Exit: Building a Patent Strategy Appropriate for Each Stage Mr. Joel Beider Innovation Exercise 2: Develop a New Cardiovascular Product Team Presentations Coffee and Networking Break Digital Health Revolution - A New Player in the Innovation Market Prof. Peter J. Fitzgerald The Corporate View of Technology Assessment and Acquisitions Mr. Jitesh Tank Cardiovascular Medical Device Innovation: A Discussion Q&A Panel Prof. Chaim Lotan, Prof. Rafael Beyar, Dr. Martin T. Rothman, Prof. Paul Iaizzo, Prof. William Durfee, Dr. Todd J. Brinton, Dr. Peter J. Fitzgerald, Mr. Jitesh Tank, Dr. Semih Oktay, Mr. Joel Beider, Mr. Xavier E. Pardo, 17:00 Adjourn DECEMBER 4 TH, :30-10:10 The Vulnerable Plaque - Regression, Progression and Beyond, Hall A 08:30 08:42 08:54 09:06 Chairs: Gregg W. Stone, ; Ling Tao, China; The Vulnerable Plaque - Is it a Valid Target for Treatment? Yoseph Rozenman New Intravascular Imaging Devices: What is in the pipeline? Patrick W. Serruys Netherlands Near Infrared Spectroscopy to Detect Vulnerable Plaque: The PROSPECT II Study Gregg W. Stone

3 Evolocumab: Translating LDL-C Lowering into Plaque Regression Rafael Bitzur 09:18 A New Nano-Polymer to Treat the Vulnerable Plaque Jonathan Leor 09:30 Bioresorbable Scaffold Treatment of Vulnerable Plaques: the PROSPECT_ABSORB Trial Gregg W. Stone 09:42 Panel Discussion How Can We Detect and Treat Vulnerable Plaque? 08:30-10:06 Needs and Problems Around TAVR, Hall B 08:30 08:42 08:54 Chairs: Martin B. Leon, ; Ariel Finkelstein, ; Ran Kornowski, Innovations in Large Caliber Vascular Closure M. Barbash Bicuspid Aortic Stenosis Treated with the Repositionable and Retrievable Lotus Valve System Alberto Cremonesi Italy 09:06 09:18 09:30 Tissue Valves Durability: Should We Worry THV Degeneration? Danny Dvir Aortic Leaflet Restoration Using Lithoplasty: A Paradigm Shift in Treatment of Aortic Stenosis Todd J. Brinton TAVR and Coronary Occlusion Ariel Finkelstein Quantitative Aortography for Assessment of TAVR: Prognostic Value Correlation with Echo and Technical Validation

4 Patrick W. Serruys 09:42 TAVI for Bicuspid Aortic Valve Jean-Claude Laborde France 08:30-10:06 Anti Platelet and Antithrombotic Therapy, Hall C 08:30 Chairs: Ron Waksman, ; Eugenia Nikolsky, 08:42 08:54 09:06 09:18 09:30 Anti Platelet and Anti Thrombotic Therapy in ACS - Current Perspective and Unmet Needs Eli Lev DAPT Reduction in Diabetic Patient Treated with PCI; Results of the UCre8 Study Pieter R. Stella Netherlands Platelet Mechanobiology and Mechanical Circulatory Support: Opportunities to Address the "Right" Targets Marvin J. Slepian ACS and Heart Failure - How Do We Manage Antithrombotic Therapy Idit Dobrecky Mery Pharmaco-Invasive Strategy for STEMI Quang N. Nguyen Vietnam Optimal Length of DAPT: Have We Reached a Consensus Ron Waksman 09:42 09:54 New Ways of Administering Anti-Aggregant Treatment in ACS Patients Elad Asher Acoustic Pulse Thrombolysis for the Management of Sub-massive Pulmonary Embolus

5 Andrew SP Sharp UK 08:30-10:30 Acute Coronary Syndrome and Cardiogenic Shock, Hall H 08:30 Chairs: Jacob George,, Fang Weiyi, China; Doron Aronson, Coronary Clot in STEMI: Role of Aspiration Despite Current Literature: Case Based Presentation Graham Cassel South Africa 08:42 08:54 09:06 Late Presentation of STEMI: Does Biomarker Make Difference Quang N. Nguyen Vietnam Cardiogenic Shock in ACS - Current Perspectives and Unmet Needs Doron Zahger 09:18 09:30 09:42 09:47 ST-Segment Elevation Myocardial Infarction: an Ideal Subset for Bioresorbable Vascular Scaffold Implantation? Alfonso Ielasi Italy ACS Treatment in the Last Decade: What Have We Learnt From the ACSIS Registry Shlomi Matetzky Noninvasive Neural Rebalance Approach for the Treatment of Ischemia and Reperfusion Injury in Patients with ST-Elevation Myocardial Infarction: A Proof-of- Concept Study Hong Jiang China The Diagnostic Value of Novamed s Sens-A-Heart Rapid Assay in Patients with Definite and Possible ACS Boris Varshitzky 1

6 The system of Controlled Automated Reperfusion of the whole Body - Delighting News regarding Survival and Neurologic Recovery in the field of Cardiopulmonary Resuscitation Georg Trummer Germany 08:30-10:23 Imaging, Physiology and Beyond, Hall I 08:30 Chairs: Gary S.Mintz, ; Gad Keren, ; Carlos Cafri, High Definition IVUS: Current Applications Gary Mintz 08:42 08:54 09:06 09:18 09:30 09:42 09:54 Latest Study on FFR Computation from Angiogram, Without Hyperhemia William Wijns Belgium Co-Registration Of Intra-Coronary Physiology Measurements By ifr With Angiography Andrew SP Sharp UK New Developments in FFR and Pressure Wire Tibor Szuk Hungary Physiology Co-Registration Aaron Frimerman Holographic Cardiac Imaging in the Cath Lab Elchanan Bruckheimer Developing the Optimal Environment for Image Guided Procedures Barry T. Katzen Central Aortic Waveform and Arterial Stiffness Eduardo Podjarny

7 10:06 Physiology Extension Beyond the Epicardial Stenosis Amir Lerman 08:30-10:30 The Triangle of Innovation: Academy - Hospital - Industry, Hall J 08:30 08:42 Chairs: Rafi Beyar, ; William Wijns, Belgium; Marc A. Turco, Innovation - Collaborating Between Partners Rafi Beyar Challenges in Designing the Optimal Environment for Clinical Innovation Barry T. Katzen 08:54 09:06 09:18 Barriers and Opportunities for FIH Projects Through Pivotal Studies Carlos Granada Winners and Losers in VC Backed Cardiovascular Device Innovation - What Does It Mean for CV Start Ups Now Katie Ellias France Cardiac Research and Innovation - Can They Be Coupled? Amir Lerman 09:30 The Power of Collaboration: Science, Industry and the Clinic David Knapp 09:42 Development of a High-Fidelity Simulation Curriculum into Training of Medical Students, Residents, and Fellows: Creation of a First-Hand Operator Experience and Assessing Excellence Versus Competency Zachary Bercu 09:54

8 Development of an Integrated Innovation Program into Interventional Radiology Residency and Fellowship Michael Miller 10:06 Tactics for Successful Patent Outcomes in the Medical-Device Space Reuven K. Mouallem 08:30-10:17 Technology Parade I - Devices, Room 4 08:30 Chairs: Ruth Alon,, Charles A. Simonton, ; Katie Ellias, France; Paul Miller, NewPace Medical - The NewPace Subcutaneous String Defibrillator - A New Paradigm in Cardiac Rhythm Management Gera Strommer 08:40 SurModics Surmodics Advancements - Developing Highly Differentiated Vascular Product Solutions Gregg Hamel 08:50 Rapid Medical New Era in Neuro Intervention Sourour Nader 09:00 Tetra Sense Structural and Component Fatigue of Cardiac Prosthesis Utilizing Frictionless Actuator Technology Massimo Baiardo 09:10 Bendit The New Generation of Microcatheters: The Bendit Revolution Chaim Lotan 09:20 CardiacSense A Novel Bio-Sensing Technology for Detection of Atrial Fibrillation Eldad Shemesh 09:30 Clinical Experience with the innovative B-Laser for PAD

9 Waclaw Kuczmik 09:40 Heart Regeneration Technologies Heart Regeneration Becomes Reality Johannes Holfeld 09:50 BackBeat Medical Programmable Hypertension Control (PHC) - A Pacemaker - Mediated Novel Approach for the Treatment of Hypertension Yuval Mika 10:00 Development and testing of a novel and smart hybrid IVUS-OCT sensor for intravascular imaging Ram Ramalingam 10:00-10:30 Coffee Break And Exhibition Visit, Exhibition Area 10:30-12:30 Plenary Session I, Hall ABC 10:30 10:40 11:05 11:30 Greetings, Opening Remarks and Acknowledgments Prof. Rafi Beyar, Prof. Chaim Lotan, Prof. Fausto Pinto, Prof. Junbo Ge ipscs for Precision Cardiovascular Medicine Dr. Joseph Wu Will Mitral Valve Replacement Be TAVR 2? Dr. Martin B. Leon Live Case Transmissions from Shaare Zedek Medical Center Panel: Rafi Beyar, Chaim Lotan, Horst Sievert, Ariel Finkelstein, Giora Weitz 12:30-14:00 Lunch Break & Exhibition Visit, Exhibition Area 12:40-13:40 Lunch Session

10 12:40-13:40 LUNCH SESSION 12:40-13:40 LUNCH SESSION 14:00-15:30 -China Wall to Wall I, Hall A 14:00 Signing Ceremony ICI and CCI, Newly Established Cardiovascular Association (ICICO) Focusing on Academic Cooperation Between and China ICI 和 CCI 签约仪式中以心血管创新合作组织 ICICO 正式成立 Arnon Afek 教授 - 以色列卫生部长 Mr. Avi Luvton, Director of Asia Pacific and China, Chief Scientist of, i Innovation Authority Prof. Chaim Lotan Director and founder ICI Meeting, Head of Cardiology, Hadassah Medical Center. Chaim Lotan 教授 - ICI 大会创始人,Hadassah 医学中心心脏中心负责人 14:20 中国心血管技术的挑战与机遇 14:40 15:00 葛均波教授 - 中华医学会心血管病分会主任委员, 复旦大学附属中山医院心内科主任 -China Cardiovascular Innovation Cooperation Organization, ICICO introduction by Prof. Chaim Lotan 中以心血管创新合作组织 ICICO 的介绍搭建全球领域内的心血管创新平台 East Meets West Dr. Yuval Binur 15:10 Investment in Healthcare from a Doctor's Point of View 圆桌论坛及总结 Prof. Chaim Lotan 圆桌主持 :Chaim Lotan 教授 Prof. Jie Wang, Chief Executive new ICICO alliance 14:00-15:40 Interventional Cardiology: Live from the Catheterization Laboratory, Hall B Chairs: Darius Dudek, Poland; Amit Segev, ; Yanai Ben-Gal, Moderators: Francesco Maisano, Switzerland; Ran Kornowski,

11 14:00 Interventional Cardiology: Past, Present, Future Christodoulos Stefanadis Greece 14:12 Live Cases 14:48 Heart Team or Hard Team - Where is the Border? Oz Shapira 15:00 Mechanisms of Stent Thrombosis: Is Improved Technology the Answer? Juan F. Granada 15:12 How Does New Technology Improve Results in Mitral Valve Repair? Ehud Raanani 15:24 Panel Discussion 14:00-15:53 Stents - Coating, Eluting and Beyond, Hall C 14:00 14:12 Chairs: Patrick W. Serruys, The Netherlands; Uri Rosenschein, ; BRS: Proven Outcomes Patrick W. Serruys Netherlands Unveiling the Causes of BRS Thrombosis: From the Obvious to Novel Mechanistic Causes Juan F. Granada 14:24 14:36 From innovation to standard of care? The latest evidence for ultrathin, bioresorbable polymer DES Clemens Von Birgelen Netherlands First-in-Men for Thin-Strut, Chromium-Cobalt Version of the Dedicated Bifurcation Stent BiOSS LimC: 6 Months Follow Up

12 Robert J. Gil Poland 14:48 Polymer-Free Stents: The Medtronic Drug-Filled Stent and Results of the REVELUTION Study Gregg W. Stone 15:00 Building the Next Chapter in Complex PCI: Biodegradable Polymer DES, FRS and Beyond Keith D. Dawkins 15:12 MeRes Bioresorbable Stents: Design Features and Early Human Clinical Outcomes Martin B. Leon 15:24 Ultimaster: the Ultimate Design for Mastering Complexity Haim Danenberg 15:36 Novel PGA Fiber Textile Technology and Immunomodulation with PGS Coating for Improved Neotissue Formation of Small Diameter Tissue Engineered Arterial Grafts Narutoshi Hibino 1 14:00-15:40 Value-Based Healthcare, Hall H 14:00 14:24 14:36 14:48 Chairs: Rafi Beyar, ; Varda Shalev, ; Mike Berman, Value Based Healthcare (VBHC) Concept and Its International implementation Maarten Akkerman Switzerland A new Model for Value Creation in the Medtech Industry Uri Geiger Leading the Way in Collaborative Cardiovascular Care Sean Salmon Clinical Trial Design With An Eye Towards Value, Economics and Reimbursement

13 Mitchell Sugarman 15:00 Panel Discussion Moderators: Maarten Akkerman, Switzerland; Arnon Afek, ; Sean Salmon, ; Varda Shalev, ; Charles A. Simonton, ; Yaron Itzhari, 14:00-15:30 Stroke and Neurovascular Interventions -, Hall I 14:00 Chairs: Adnan Siddiqui, ; Francis Turjman, France; ATNT (Advanced Treatments in Neuro Therapeutics) Aviv Lotan 14:04 The Pre-Stroke Referral Eitan Abergel 14:16 Imaging: Stroke Protocol, Modalities, Aspects Score, Penumbra Evaluation David Orion 14:28 Acute Stroke Interventions: Technique, Lessons Learned.. Horst Sievert 14:40 Acute Stroke Intervention; We Do Actively Stroke Intervention in Our Lab as Cardiologists Ömer Göktekin 14:52 ADAPT: A Direct Aspiration first Pass Technique for Acute stroke Thrombectomy Francis Turjman 15:04 Flow Diversion - A Promise Fulfilled Rotem Sivan-Hoffman

14 15:16 Future: Stretching the Envelope for Endovascular Treatment - New Techniques and Devices Adnan Siddiqui 14:00-15:53 Structural Heart Desease, Hall J Chairs: James K. Min, ; Horst Sievert, Germany; Paul Fefer, 14:00 Watchman The Latest Clinical Evidence Alec Vahanian 14:12 A Randomized Trial Comparing Amplatzer and Occlutech ASD Occluder Horst Sievert 14:24 LAA Closure in What's Next? Sameer Gafoor 14:36 14:48 Stent Fenestration of Atrial Septum in Idiopathic Pulmonary Arterial Hypertension Treatment Bagrat Alekyan Russia A Novel Guiding Catheter to Improve the Safety of Percutaneous ASD Closure Under Echocardiography Guidance Without X-Ray Wenbin Ouyang 15:00 Peri-Prosthetic Leak Closure - What Can Be Done to Improve Our Experience? Rafael Hirsch 15:12 Clinical Experience of Left Atrial Appendage Occluder (Lifetech LAmbre Device) in China Yawei Xu 15:24 Bald Aortic Arch in Takayasus Aorto-arteritis- Endovascular Management

15 Rajesh vijayvergiya 14:00-15:46 Technology Parade II - Imaging & Digital, Room 4 Chairs: Nissim Darvish, ; Nadav Ben Haim, ; Moshe Flugelman, 14:00 How to Strategize and Plan Your Start-Up Kathleen Marshall 14:12 FDA is Changing! But it Will Take Some Time Susan Alpert 14:24 Pangolin Simulators Endovascular Simulators from R&D to First in Man Ohad Shafran 14:34 Genae Ongoing Changes in the Regulatory Environment Aly Talen 14:44 RealView Imaging True 3-D Holograms for Structural Cardiology Interventions Aviad Kaufman 14:54 HealthWatch Technologies World s 1st Medical-Grade Hospital-Quality Digital Garment Hila Dagan 15:04 15:14 A new tool for long term arrhythmia monitoring Zvika Shinar Sensible Join the REDS Revolution in the Management of Heart Failure Amir Ronen

16 15:24 Ultrasound Based Real-Time Monitoring System for Cardiac RF Ablation Yossi Abu 15:30-16:00 Coffee Break & Exhibition Visit, Exhibition Area 15:45-17:30 -China Wall to Wall II, Hall A 15:45 圆桌论坛 : 中国人眼中的以色列故事 中国健康领域面临的挑战 - 从众多以色列初创企业中先选出了五家来展示其创新技术. 投资专家点评中国健康领域面临的挑战 - 从众多以色列初创企业中先选出了五家来展示其创新技术. 投资专家点评 China Challenge moderator Mr. Cai Cong, CEO Shareplus, Investment Director, Sharecapital Chosen Startups TBD 16:00-17:30 ICI Innovation Award Competition, Hall B Judges: Todd J. Brinton, ; Elazer Edelman, ; Juan F. Granada, ; Carlos Granada ; Chaim Lotan, ; Kathleen Marshall, ; Xavier E. Pardo, ; Irit Yaniv, TBD 16:00-17:58 Mitral Disease - A Challenge to Innovators, Hall C 16:00 16:12 Chairs: Alec Vahanian, France; Renu Virmani, ; Management of Mitral Valve Disease: What Are the Unmet Needs? Alec Vahanian France Mitral Valve Repair or Replacement - The Pathologist Perspective Renu Virmani 16:24

17 MitraClip for Secondary MR in Heart Failure: COAPT Design and Results from the Run-in Phase Gregg W. Stone 16:36 Transapical Mitral Chordae Implantation Horst Sievert 16:48 Challenges in Developing the Next Transcatheter Mitral Valve Replacement System Sean Salmon 17:00 Cardioband - Performance Measurement Systems Introduction, Future Studies and Publication Strategy Ori Ben-Yehuda 17:12 The Importance of Percutaneous Trans-apical Approach for Valvular Interventions Hendrik Treede 17:24 Mitra Clip and Ventricular Reshaping Stefan D. Anker Germany 17:36 The Cipher s TMVR (Trans-Septal) System Juan F. Granada 17:48 Transfemoral System for Mitral Valve Reconstruction Up to 2 Years Multicentre Trial Results Vahanian Alec 1 France 17:53 Transcatheter mitral valve repair toward a surgical standard: direct annuloplasty with a Cardioband device to treat severe residual mitral regurgitation after MitraClip Shingo Kuwata Switzerland

18 16:00-17:50 Big Data - Analytics and The Impact on Healthcare, Hall H Chairs: Peter J. Fitzgerald, ; Michal Geva, ; Dan Shwarzman, 16:00 Analytics, Attitude and Achievements in Healthcare Peter J. Fitzgerald 16:12 EMRs and Decision Modulation in the Hospital Ran Balicer 16:24 How Do We Deal with Big Data Stefan Verheye 16:36 Advanced CDS: Making Patients, Physicians and Health Plans into Partners Eyal Ephrat 16:48 When HIPAA needs Cybersecurity Eyal Zimlichman 17:00 17:12 Developing and Implementing Precision Medicine in the Communit Varda Shalev The Digital Case Study Yair C. Schindel 17:24 Closing The Loop On Digital Health Ari Fried 17:36 Panel Discussion The Impact on Global Impact of Collision of IT and Life Science Moderators: Peter J. Fitzgerald, ; Michal Geva, ; Eyal Ephrat, ; Yair C. Schindel, ; Ittai Harel,

19 16:00-17:30 Cell Therapy and Regenerative Medicine, Hall I Chairs: Joseph C. Wu, ; Lior Gepstein, ; Jonathan Leor, 16:00 TBD Joseph C. Wu 16:12 CHART-1 Trial: Insights and Learnings from Exploratory Analyses Jozef Bartunek 16:24 Fundamental Issues in Stem Cell Therapy Piotr Musialek 16:36 Cardiac Resident Stem Cells - A Call to Action? Ronen Beeri 16:48 Genomic Determinants of Cell Fate and Growth in the Heart Izhak Kehat 17:00 Injectable Hydrogels: A Novel Catheter-based Approach to Tissue Engineering in Advanced Heart Failure Warren Sherman 17:12 Pluripotent Stem Cells Applications for Cardiovascular Regenerative Medicine Lior Gepstein 17:24 Adult Stem/Progenitor Cells as a Personalized Treatment for Vascular Disease Offer Galili 1 16:00-17:50 Autonomic Modulation and Beyond, Hall J 16:00 Chairs: Felix Mahfoud, Germany; Morris Mosseri, New and Revisited Targets for Autonomic Modulation: the Pathophysiology Behind

20 Rami Tzafriri 16:12 Phrenic Nerve Stimulation for Central Sleep Apnea Stefan D. Anker Germany 16:24 Renal Denervation, What the UK Experience Tells Us and Why We Must Keep Going Andrew SP Sharp UK 16:36 Aortic Arch Stimulation Felix Mahfoud 16:48 Pulmonary Artery Denervaiton for the Treatment of Pulmonary Arterial Hypertension: Pre-clinical Data and Early Clinical Results Alex Rothman 17:00 New Devices for CHF and Resistant Hypertension: Focus on Baroreflex Activation Therapy and Carotid Body Modulation Gary Gershony 17:12 Update on Ongoing Studies in Renal Denervation: What These Trials Will Answer, What Not? Michael Bohm 17:24 One year results from The Peregrine Study of alcohol-mediated renal denervation in refractory hypertension Wojciech Wojakowski 1 Poland 16:00-17:41 TAVR - Outcomes and Related Issues, Room 4 16:00 Chairs: Adam Witkowski, Poland; Keith D. Dawkins, ; Francesco Maisano, Switzerland Optimization of TAVI outcomes - Better Patient Selection and Prevention of Complications Amit Segev 16:12

21 Reposintional Self Expanding Aortic Bioprosthesis: FORWARD Trial and TVT Registry Stephen J.D. Brecker UK 16:24 TAVI in patients with challenging aortic root anatomy Renat Akchurin Russia 16:36 Live in a box case Adam Witkowski 16:48 TAVR Alternative Access Ulrich Schaefer 17:00 TAVR and Stroke Prevention Eberhard Grube 17:12 Portico TAVR Francesco Maisano 17:24 Contrast Zero TAVR: Safety and Feasibility of Transcatheter Aortic Valve Implantation Without the Use of Contrast Media Alberto Cremonesi Italy 17:36 Tavi Through the Carotid Artery Access Under Local Anesthesia /A Series of 50 Patients/ Ernoe Remsey-Semmelweis 1 Germany 17:30-18:00 Technology Parade Cocktail, Exhibition Area 18:00-19:30 Brain Protection, Hall A 18:00 Chairs: Azeem Latib, Italy; Pieter R. Stella, The Netherlands; Arthur Kerner,, Jose Cohen, Brain Protection During TAVI - A Real Unmet Need Haim Danenberg

22 18:12 Why Cerebral Embolic Protection Should be Standard of Care? Renu Virmani 18:24 Cerebral Protection During TAVR: Update on Real-World Regisitry Using the TriGuard Pieter R. Stella Netherlands 18:36 Complete Cerebral Embolic Protection Utilizing TriGuard Azeem Latib 18:48 CBF, Autoregulation and Multi Modal Brain Monitoring Moshe Kamar 19:00 Cerebral Protection During TAVR - the Evidence is Building Ron Waksman 19:12 Brain Protection During TAVR -The Emboline Approach Chaim Lotan 19:24 Selective Cerebral Hypothermia: A New Tool to Really Cool Ronald Solar 18:00-19:30 Advanced Coronary Interventions, Hall B 18:00 Chairs: Robert J. Gil, Poland; Jiyan Chen, China; Unmet Needs in Complex Lesions: Calcification, Bifurcation and Beyond Abid Assali 18:12 Lithoplasty for Calcified Coronary Artery Preparation Prior to Stenting: DISRUPT CAD Study Results Todd J. Brinton

23 18:24 Syntax Score II in Choosing Optimal Mode of Myocardial Revascularization: Our Experience in the First 1000 Patients Miodrag Ostojic 18:36 Protected PCI with LVAD in Complex Interventions Dudek Dariusz Poland 18:48 Is Rotablation Still Alive? T.S. Kler 19:00 A Synergy of Bioresorbable Vascular Scaffold and Drug Eluting Stent for the Treatment of Left Main Bifurcation: Tools for Intervention and Follow-up Andrejs Erglis Latvia 19:12 Percutaneous Treatment of Aorto-Ostial Coronary Lesions: Current Challenges and Future Directions Ronen Jaffe 18:00-19:50 Present and Future in the Cath Lab, Hall H TBD 18:00-19:36 My Crazy TAVR Case, Hall I 18:00 18:12 Chairs: Martin B. Leon, ; Eberhard Grube, Germany; Ariel Finkelstein, TAVI and Coronary Occlusion: A Challenging Case Jean-Claude Laborde France The Horn of Plenty: A TAVR Tripleheader Martin B. Leon 18:24 Symedwards: Story of a Valve-in-Valve Corrado Tamburino 18:36

24 LVOTO After Sapien in MAC Francesco Maisano 18:48 The Bigger the Better? Not always! Eberhard Grube Germany 19:00 Transcatheter Aortic Valve and Mechanical Mitral Valve - Not Good Mates! Amit Segev 19:12 "Just Another Horst Crazy TAVI Case" Horst Sievert 19:24 Lotus Aortic Valve-in-Valve Implantation to Treat Degenerated Hancock II Bioprosthesis Adam Witkowski Poland DECEMBER 5 TH, :00-08:00 Breakfast Session 08:30-10:30 Updates on Mitral Interventions, Hall A Chairs: David A. Halon, ; Timur Imaev, Russia; Shmuel Banai, 08:30 Transeptal Mitral Valve Implantation: Innovation and Evolution of a New Therapeutic Technique Charanjit S. Rihal 08:42 The MitrAssist Mitral Valve: a Truly Transfemoral Mitral Valve Replacement System Carlos E. Ruiz 08:54 Design Challenges in TMVR: Impossible or Just Near Impossible? Juan F. Granada 09:06

25 Mitral Valve Repair What Seems to be the Preferred Technology Francesco Maisano 09:18 Percutaneous Mitral Interventions Dariusz Dudek 09:30 Cardioband - Transfemoral Adjustable Solution for Your MR Patients Alec Vahanian France 09:42 Mitral Valve Replacement - The Tiara Approach Shmuel Banai 09:54 Transcatheter Mitral Valve Replacement - Update on the Tendyne System Francesco Maisano 08:30-10:06 Bioresorbable Scaffolds, Hall B Chairs: Ron Waksman, ; Juying Qian, China; Alex Goldberg, 08:30 Tutorial on Erodible Materials Elazer Edelman 08:42 08:54 Lessons Guiding Design of Next Generation BRS Richard J. Rapoza Current Status of Bioresorbable Scaffold in China Junbo Ge 09:06 09:18 Pioneering Resorbable Technology in our hands: Magmaris Magnesium Scaffold Ron Waksman Clinical Outcomes After ABSORB Bioresorbable Vascular Scaffolds Implantation in Routine Clinical Practice

26 Corrado Tamburino Italy 09:30 Elixir Bioresorbable Stents: Differentiating Design Features and Clinical Status Update Martin B. Leon 09:42 Progress Towards the Development of a Thin-Walled Novel PLLA Based BRS: The Amaranth Program Juan F. Granada 09:54 Coronary Imaging Guide Implanting Bioresorbable Scaffolds Yundai Chen 08:30-10:10 TAVR - Current and Future I, Hall C 08:30 08:42 08:54 Chairs: Marie-Claude Morice, France; Chang Shu, China; Vladimir Turkisher, TAVR in Intermediate Patients Corrado Tamburino Italy Expanding TAVR Indications: The EARLY-TAVR and TAVR-UNLOAD Trials Ori Ben-Yehuda Building the Next Chapter in Transcatheter Valves - Lotus Edge and Beyond Keith D. Dawkins 09:06 09:18 Streamlining TAVI for Lower Risk Patients : One Size Fits All or a Structured Approach? Stephen J.D. Brecker UK Clinical Outcome of TAVR With VitaFlow(made in China) in Chinese population Jianan Wang 09:30

27 Acurate Neo: Top-Down Deployment Translates into Stable, Precise Positioning and Successful Procedures: Symetis TAVI Highlights Yaron Almagor 09:42 AVALUS Clinical Evidence: Perigon Study, Setting the New Standards for Surgical AVR, Designed for Future VIV Francesco Pirone UK 09:54 Bioprosthetic Valve Durability Considerations: Perspectives and Clinical Relevance Martin B. Leon 08:30-10:18 Vascular Session I - Aortic Interventions (In Collaboration with TBD Hall H TBD 08:30-10:00 Devices in the Management of Heart Failure, Hall I 08:30 Chairs: Piotr Ponikowski, Poland; Michael Böhm, Germany; Basil Lewis, ; Michael Kleiner Shochat, Trans-Catheter Mitral Valve Repair as Treatment for Heart Failure Mony Shuvy 08:42 CRT, ICD, CCM, Indications and Outcomes, to Whom and When? Frank Ruschitzka 08:54 09:06 Interatrial Shunting as a Treatment for Heart failure Lessons Learned Neal L. Eigler What is New in the VAD World and What is Waiting in the Near Future? Avishay Grupper 09:18 Total Artificial Heart - Present and Future Status

28 Marvin J. Slepian 09:30 Continuous Flow Mechanical Circulatory Support: Challenges and Opportunities Marvin J. Slepian 09:42 Panel Discussion 08:30-10:00 Electrophysiology I: Arrhythmia Mapping and Ablation, Hall J 08:30 08:42 Chairs: Bernard Belhassen, ; Monther Boulos, ; Sami Viskin, Ablation of Persistent AF- the Role of Voltage Mapping for Individualized Treatment Strategies Philipp Sommer Germany Implantable Stent-Graft for Pulmonary Vein Isolation Glenn Van Langenhove 08:54 Ablation of AF in Interventional MRI: Fiction or Reality in Near Future? Philipp Sommer 09:06 New Ideas and Directions in AF Ablation Assaf Govari 09:18 Use of Crio Energy for Papillary Mussel VT Ablation - Case Presentation Ibrahim Marai 09:30 A Novel Bio-Sensing Technology for Detection of Atrial Fibrillation Sami Viskin 09:00-17:00 Hands-on Workshop 09:00 TBD

29 10:00-10:30 Coffee Break And Exhibition Visits, Exhibition Area 10:30-12:30 Plenary session II, Hall ABC 10:30 11:00 Award Ceremony The Middle East and - Facing the Challenges of the Future Maj. Gen. (Res.) Amos Gilad, Director of Political-Military Affairs, i Ministry of Defense 10:30-12:30 Vascular Session II - Interventional Radiology (In Collaboration with TBD), Hall H TBD 12:30-14:00 Lunch Break & Exhibition Visit, Exhibition Area 12:40-13:40 LUNCH SESSION 12:40-13:40 LUNCH SESSION 12:40-13:40 LUNCH SESSION 14:00-16:00 Vascular Session III - Carotid & Lower Extremities Interventions (In conjunction with TBD), Hall A TBD 14:00-16:12 Device Innvoation, Hall B 14:00 14:15 Chairs: Ruiyan Zhang, China; Nicholas Borenstein, France; David Meerkin, ; ICI - Innovating and Collaborating with Industry Jeff Mirviss State of Innovation Elazer Edelman 14:27 Device Innovation in the Current Era

30 Michael Berman 14:39 The Practice of Intraneurship; Innovation in a Large MedTech - Why Large Companies Cannot Innovate Stanton Rowe 14:51 Medical Device Innovation: From Concept to Commercialization Gary Gershony 15:02 Cardiovascular Device Innovation in China Xiangqing Kong 15:14 Reducing Risk in Research Based Health Technology Startups Harold Solomon 1 15:26 Research and Development of 3D Printed Conical Bionic Bioabsorbable Stent Yujie Zhou 15:38 The Challenge of Bringing 1st Generation BVS Device to Market Regina Deible 14:00-16:10 Challenging Coronary Anatomy - CTO and Bifurcation, Hall C 14:00 Chairs: George Sianos, Greece; Jiyan Chen, China; Ariel Finkelstein, Ultimaster: The New Generation DES for Bifurcation and Complex Lesions Corrado Tamburino 14:12 Dealing with Technical Uncertainties in Bifurcation Stenting: Kissing Balloons, POT and re-pot Ioannis Iakovou 14:24

31 Bifurcation Dedicated BiOSS Expert and BiOSS Lim Stents vs Regular Drug Eluting Stents: Five and Three Years Clinical Outcome of the Patients Enrolled into POLBOS 1 and 2 Randomized Studies Robert J. Gil Poland 14:36 Contemporary Aspects of the Retrograde Techniques in CTO PCI Georgios Sianos Greece 14:48 Left-Main Bifurcation Stenting - A View From the Inside Azeem Latib 15:00 TOSCA-5 Clinical Trial- Results and Future Directions Bradley H. Strauss 15:12 Efficacy and Safety of Novel NovaCross Microcatheter for Coronary Chronic Total Occlusions: First-in-Human Study Ran Kornowski 15:24 Tryton - Clinical and Regulatory Update Aaron V. Kaplan 15:36 The Efficiency of the Hybrid Algorithm in CTOs Michael Koutouzis 14:00-15:34 The Tricuspid Valve - A New Challenge, Hall H Chairs: Jean-Claude Laborde, France; Chaim Lotan, ; Erez Sharoni, 14:00 Tricuspid Repair - What Should We Know About It - The Pathologist Perspective Renu Virmani 14:12 What is the Future of Transcatheter Tricuspid Valve Interventions?

32 Alec Vahanian 14:24 Transcatheter Treatment of FTR Azeem Latib 14:36 Clinical and Procedural Challenges in Treating Tricuspid Regurgitation and a New Approach with the DaVingi TR System Arthur Kerner 14:48 New Approaches for Tricuspid Valve Repair Gidon Perlman 15:00 Transcatheter Adjustable Annuloplasty Device for Mitral and Tricuspid Repair - The Cardiac Implants Device Carlos E. Ruiz 15:12 A Novel Transcatheter Tricuspid Valve Repair System: The TriCinch Approach Jean-Claude Laborde 1 Italy 14:00-15:30 Unfulfilled Needs & Therapeutic Achievements in Heart Failure, Hall I 14:00 Chairs: Frank Ruschitzka, Switzerland; Marvin J. Slepian, ; Gotsman, ; Offer Amir, Pharmacological and Device Modulation of the Neuroendocrine System Michael Böhm 14:20 What are the Best Endpoints in Development of Treatments and of Devices in Heart Failure Amir Lerman 14:32 Devices in Acute Heart Failure: Present and Future Gerasimos Filippatos 14:44

33 TBD Piotr Ponikowski 14:56 Telemonitoring in HF: Ongoing Failures and Future Perspectives Andre Keren 15:08 Non-Invasive Monitoring of Patients with Heart Failure by Objective Indices of Dyspnea Shmuel Rispler 1 15:13 Panel Discussion 14:00-15:30 Electrophysiology II: Pacing, Hall J Chairs: Boris Strasberg, ; Eugene Crystal, ; Moshe Swissa, 14:00 Leads In or Out? Conflicting Directions in CIED Jay Gross 14:12 Leadless Pacing: Initial Experience and Future Potential David Luria 14:24 Thromboembolic Risk of Right Sided Implantable Devices Christopher V. DeSimone 14:36 Left Ventricular Endocardial Pacing: Novel Trans - Myocardial Approaches Yurii Karpenko 14:48 Comprehensive Image Integration to Guide the Implantation of a Wireless, Endocardial LV Electrode for the Delivery of CRT Jonathan Behar 15:00 CRT: Mature Therapy, Naïve Understanding Jay Gross

34 16:00-17:30 Vascular Session IV - Venous, Pulmonary Embolism and Dialysis Access (In Collaboration with TBD), Hall A 16:00-17:30 TAVR - Current and Future II, Hall C Chairs: Gil Bolotin, ; Ariel Finkelstein, 16:00 Are we Doing Too Many Futile TAVI cases? Amit Segev 16:12 What Should Be the ideal Valve for a Medium Risk Patient Martyn Thomas 16:24 Update on Direct Flow Medical in the Aortic & Mitral Postion Azeem Latib 16:48 Valve in Valve Implantations: Important lessons from Bench and Clinical Practice Danny Dvir 17:00 Initial Experience of a Novel TAVR System - Clinical Trail of J-Valve in China Chunsheng Wang 16:00-18:00 Special Stents and DCB, Hall H Chairs: Bruno Scheller, Germany; Juan F. Granada, ; Chenxi Ouyang, China 16:00 i Experience with Latest Generation DES in Diabetic Patients Ran Kornowski 16:12 Drug Coated Balloons for in-stent Restenosis: Emerging Evidence Versus Latest Generation DES Andrejs Erglis 16:24 DCBonly Coronary - The New Concept of Leaving Nothing Behind

35 Scheller Bruno Germany 16:36 Bionics - 13 Month Angiographic Follow Up Ori Ben-Yehuda 16:48 Designing a Complication-Free DCB: Is It Possible or Necessary? Juan F. Granada 17:00 The Value of a New DCB in Long SFA Lesions Xin Jia 17:12 Multiple drug coated balloon exposures increase arterial permeability and drug retention Rami Tzafriri 1 17:17 Next Generation DCB Catheter Adjustable, No Shear, Evaginating DCB Design Ronald Solar 16:00-17:45 Developing Technologies in Heart Failure Diagnosis and Management, Hall I 16:00 16:12 Chairs: Matrin B. Leon, ; Gerasimos Fillipatos, Greece; Jean-Marc Weinstein; Atrial Shunting in Heart Failure - the Corvia Approach Martin B. Leon Early Detection of HF Deterioration Using Digital Technologies Chaim Lotan 16:24 Sensible Managing Heart Failure with REDS Technology Ronnie Abbo 16:36

36 Heart Failure Management in the 21st Century: Finally a Synthesis of the Best of Technology and Medicine Jonathan Wiesen 16:48 CardioSet Lung Impedance Monitoring is a Simple and Effective Tool for Improving Outcome in Heart Failure Michael Kleiner Shochat 17:00 Pluripotent Stem Cells Applications for Cardiovascular Regenerative Medicine Lior Gepstein 17:12 Percutaneous Regulation of Caval Flow for Patients with Advanced Heart Failure Jose E. Herrera 17:24 BAROSTIM THERAPY: Integrated Autonomic Neuromodulation for Heart Failure and Hypertension Robert Kieval 17:29 Hydrostatic pressure gradient ultrafiltration device: A novel approach for extracellular fluids removal Nitai Hanani 1 16:00-17:30 Electrophysiology III: Electrophysiology from Bench to Bedside, Hall J 16:00 Chairs: Michael Eldar, ; Aharon Medina, ; Yair Elizur, Electroporation, Carbon Nanotubes and Beyond - Understanding Future Non Radiofrequency Approaches for Treatment of Arrhythmias Suraj Kapa 16:12 Induced Pluripotent Stem Cells for Modeling Inherited Cardiac Arrhythmias and for Drug Discovery Lior Gepstein 16:24

37 Overcoming the Translational Gap from Clinical Practice to Clinical Innovation Suraj Kapa 16:36 Optogentics Strategies for Treatment of Cardiac Arrhythmias Lior Gepstein 16:48 Techsomed BioTrace - Ultrasound Based Real-Time Monitoring System for Cardiac RF Ablation Yossi Abu 17:00 Magnetic Microcapsules for Leadless Pacing Yoram Etzi

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