Atrial Fibrillation Etiologies and Treatment. Shawn Liu Learner Centered Learning Goal

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1 Atrial Fibrillation Etiologies and Treatment Shawn Liu Learner Centered Learning Goal

2 Pathophysiology Defined by the absence of coordinated atrial systole Results from multiple reentrant electrical waves that move randomly about the atria Enhanced automaticity in left atria -> electrical remodeling with shortening of the atrial refractory period -> atrial fibrillation

3 EKG Characteristics Absence of P-waves Undulating baseline Rhythm is irregularly irregular Atrial Rate = bpm Other: LVH Bundle Branch Blocks Acute or prior MI

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5 Epidemiology One of the most common arrhythmias encountered in clinical practice Approximately 1% of the population, 2.5 million patients in the U.S., have AFib Can be considered a disease of aging Estimated prevalence will double by 2050 More than half of patients will be > 80 yo

6 Epidemiology Race: Whites > Blacks Gender: Men >> Women Age: Incidence exponentially increases with age Uncommon in pediatric population

7 Etiologies P ulmonary (pneumonia, PE, malignancy) I schemia (cardiovascular ischemia) R heumatic Heart Disease A trial Myxoma T hyroid (hyperthryoidism) E thanol/electrolyte Imbalance (low K or Mg) S timulants/surgery/sepsis

8 Co-morbidities Can occur alone (in 10-15% of patients) More commonly associated with: CHF HTN Ischemic heart disease Cardiomyopathy

9 Why We Care STROKE PREVENTION! Framingham heart study shows a 5.0 fold increase in likelihood of stroke Also shows a 1.5 to 2.0 fold higher risk of death in AFib patients by thromboembolism Other reasons: Hemodynamic dysfunction Cardiomyopathy Patients can be symptomatic (fatigue, palpitations, dyspnea, chest pain, or syncope)

10 Therapeutic Goals 1. Prevention of thromboembolism 2. Rate Control 3. Rhythm control

11 Stroke Prevention 15-25% of all strokes in U.S. can be attributed to Atrial Fibrillation Accounts for 35% of strokes in those > 75 yo ASA or Warfarin? Multitude of studies demonstrating benefit of warfarin to reduce ischemic strokes

12 Hart RG, Benavente O, McBride R, Pearce LA. Antithrombotic therapy to prevent stroke in patients with atrial fibrillation: a meta-analysis. Ann Intern Med. 1999;131:

13 Efficacy of Warfarin and ASA in Stroke Prevention Hart RG, Halperin JL. Atrial Fibrillation and Thromboembolism: A Decade of Progress in Stroke Prevention. Ann Internal Medicine. 1999,131:

14 Conclusions Adjusted dose warfarin shows best relative risk reduction when compared with ASA or placebo Greater risk of bleeding/intracranial hemorrhage associated with warfarin Must maintain INR between Keep HTN under control

15 Risk Stratification Who should be put on chronic anticoagulation? Everyone with AFib? Absolute risk (AR) of stroke increases with increasing age and co-morbid conditions. Article in JAMA 2001 combined 2 previous classification schemes to form the CHADS2 score. Gage BF, Waterman AD, Shannon W, et al. Validation of clinical classification schemes for predicting stroke: Results from the national registry of atrial fibrillation. JAMA 2001; 285:

16 CHADS2 Score C CHF or reduced LV EF (1 point) H HTN (1 point) A age > 75 (1 point) D diabetes mellitus (1 point) S previous stroke or TIA (2 points)

17 CHADS2 Score Absolute risk of stroke increases by 1.5 for each point with score of 3 giving AR of 5.9 and score of 6 an AR of 18.2 Score of 0: at low risk and may be treated with ASA alone or observation Score of 1-2: can weigh benefits/risks of warfarin vs ASA to decide Score of > 3: at greatest risk and should be treated with chronic adjusted warfarin unless there is a contraindication

18 Rate vs. Rhythm Control Initial goals in the management of AFib should be anticoagulation if needed and rate control with betablockers or calcium channel blockers Restoration of sinus rhythm should be pursued only after the above two goals have been addressed

19 Rhythm Control In theory converting someone to normal sinus rhythm (NSR) should: Improve cardiac hemodynamics Prevent LV dysfunction Maintain proper cardiac output Reduce risk of thromboembolism -> reduce risk of death

20 AFFIRM Trial Study published in 2004 in Circulation 4060 patients aged > 65 yo 2 randomized groups Rhythm control group (cardioversion plus AADs to maintain NSR) Rate control group Results: rhythm control showed no evidence in preventing the incidence of strokes and did not improve mortality. Therefore, any beneficial effects of AADs are offset by their adverse side effects. Corley SD, Epstein AE, DiMarco JP, et al. Relationships between sinus rhythm, treatment, and survival in the Atrial Fibrillation Follow-Up Investigation of Rhythm Management (AFFIRM) Study. Circulation 2004 Mar 30; 109(12):

21 Rate Control Medications Beta-blockers slow the sinus rate and decrease AV nodal conduction Atenolol, metoprolol, esmolol, and propranolol Ca 2+ blockers reduce AV nodal conduction and control the ventricular response Diltiazem and verapamil Digoxin (rarely used) is mainly given to those with CHF and AFib

22 Conversion to Sinus Rhythm Refer to your friendly neighborhood cardiologist or electrophysiologist Acute conversion recommended if there is impending hemodynamic collapse or acute cardiac ischemia Elective electro-cardioversion If AFib is present < 48 hours, cardioversion can be completed w/o anticoagulation If AFib is present > 48 hours, warfarin therapy with INR 2-3 for 3-4 weeks prior to cardioversion is necessary Continue anticoagulation for 4-6 weeks after sinus rhythm is restored

23 Cardioversion Chemical Cardioversion Class III anti-arrhythmics (dofetilide, ibutilide, or amiodarone) Class Ic (flecainide or propanenone) Sotalol or Quinidine can also be considered Radiofrequency Ablation Surgery MAZE procedure

24 References Lazar J. Atrial Fibrillation. Emedicine. Rosenthal L. Atrial Fibrillation. Emedicine. Wolf PA, Abbott RD, Kannel WB. Atrial fibrillation: A major contributor to stroke in the elderly. The Framingham Study. Arch Intern Med 1987; 147: Hagens VE, Ranchor AV, Van Sonderen E, et al: Effect of rate or rhythm control on quality of life in persistent atrial fibrillation. Results from the Rate Control Versus Electrical Cardioversion (RACE) Study. J Am Coll Cardiol 2004 Jan 21; 43(2): Wolf PA, Dawber TR, Thomas HE Jr, Kannel WB. Epidemiologic assessment of chronic atrial fibrillation and risk of stroke: the Framingham study. Neurology 1978;28:973-7.

25 References Corley SD, Epstein AE, DiMarco JP, et al. Relationships between sinus rhythm, treatment, and survival in the Atrial Fibrillation Follow-Up Investigation of Rhythm Management (AFFIRM) Study. Circulation 2004 Mar 30; 109(12): Hart RG, Benavente O, McBride R, Pearce LA. Antithrombotic therapy to prevent stroke in patients with atrial fibrillation: a meta-analysis. Ann Intern Med. 1999;131: Gage BF, Waterman AD, Shannon W, et al. Validation of clinical classification schemes for predicting stroke: Results from the national registry of atrial fibrillation. JAMA 2001; 285: Hart RG, Halperin JL. Atrial Fibrillation and Thromboembolism: A Decade of Progress in Stroke Prevention. Ann Internal Medicine. 1999,131: