Atrial Fibrillation. Wat ur di-n 2 no. Ned Gutman 6 August, 2009
|
|
- Jeffery Stevenson
- 6 years ago
- Views:
Transcription
1 Atrial Fibrillation Wat ur di-n 2 no Ned Gutman 6 August, 2009
2 2 goals in treating AF Alleviation of symptoms Reduce risk of stroke
3 Anticoagulation CHADS score Future anticoagulants Rate vs Rhythm control New therapies Drugs Ablation
4 Anticoagulation: CHADS score CHF 1 point Hypertension 1 Age >75 1 Diabetes 1 H/O TIA or stroke 2 0 points: Aspirin 1-2 points: aspirin vs warfarin 3+ points: warfarin
5 Anticoagulation: CHADS risk Events per 100 person-years Score Warfarin No Warfarin or Go, AS Hylek, EM, Chang, Y JAMA 2003;
6 Warfarin risk/benefit balance Odds ratio International normalized ratio Ischemic stroke Intracranial bleeding Fuster V et al. Circulation. 2006;114:e257-e354.
7 What % of patients have INR within therapeutic range? A 95% B 85% C 75% D 65% F 55%
8 Adequacy of anticoagulation of anticoag Even with intentions to follow the guidelines, and with patient cooperation, effective anticoagulation is erratic at best INR often deviates outside of the therapeutic range Dietary fluctuations Changes in bowel flora Interactions Formulation substitution Lab errors Other Time that INR is in therapeutic range is variable even when patients are managed carefully Courtesy of JA Reiffel, MD.
9 Patients don t like Warfarin Rat poison Frequent blood test Bruising Food interactions Inconvenient to travel
10 Home INR monitor Fingerstick, just like glucometer Immediate results Flexibilty for travel/shut-ins Current usage mandates weekly testing Requires insurance approval
11 Rivaroxaban Factor Xa inhibitor Once daily oral dosing Effective 3 hours after 1st dose No food interactions Favorable results in preventing post-op DVT after hip & knee surgery Increased major bleeding (0.4 vs 0.2%) Rare liver events with 1 death No monitoring of coagulation parameters
12 Rivaroxaban: ROCKET AF Patients with AF Double blind, Warfarin vs Rivaroxaban CHADS score 3 15,000 patients enrolled
13 Rate vs Rhythm control No survival benefit with rhythm control Stroke risk not different Rhythm control does not obviate need for anticoagulation Symptoms often related to optimizing rate All antiarrhythmics have risks
14 misconceptions Misconceptions about rhythm-control strategy N = 148 PCPs from 36 US states Respondents (%) Helps avoid long-term anticoagulation Decreases mortality Decreases stroke McCabe JM et al. Am J Cardiol. 2009;103:535-9.
15 Cumulative mortality (%) Affirm outcome AFFIRM: Primary outcome N = 4060 with AF Age 65 years or 1 risk factor for stroke or death 1 st AF episode: 36% No contraindications for warfarin Follow-up 3.5 years Predominant diagnosis Hypertension 51%, CAD 26% n = 2033 rhythm control n = 2027 rate control P = 0.08 Rhythm control Rate control Time (years) AFFIRM Investigators. N Engl J Med. 2002;347:
16 Rate control Typically achieved with 1-2 meds Usual agents: B-blockers Ca-blockers (diltiazem, verapamil) Digoxin- often avoid in very elderly due to risk of toxicity Amiodarone used rarely only when unable to tolerate other agents
17 Rhythm control Success is not the same as cure or 100% reduction in AF burden Amiodarone most effective but also has most side effects Avoid Class I agents in patients with CAD or CHF Avoid Sotolol in patients with LVH
18 Rhythm control Very hi recurrence rate of AF Many AF episodes will be asymptomatic Under-recognize true AF burden Need to maintain anticoag in all patients, unless low CHADS score
19 Amiodarone Requires monitoring of LFTs & TFTs Annual PFTs - measure diffusing capacity Effects digoxin and warfarin levels, usually reduce both to 1/2 dose Corneal micro deposits up to 90% Frequent GI side effects (30%) Less pro-arrhythmia (TdP) than other agents Co- administration with ACEI/ARB even more effective
20 AF prevention with ACEI or ARB plus antiarrhythmic AF pevention drug w ACEI + Amio N = 177 with lone paroxysmal AF Group 2 Amiodarone + losartan 0.7 Group 3 Amiodarone + perindopril AF recurrencefree survival Group 1 Amiodarone Group 1 vs 2: P = Group 1 vs 3: P = 0.04 Group 2 vs 3: P = Time after randomization (days) Yin Y et al. Eur Heart J. 2006;27:
21 Dronedarone new amiodarone Does not have I moiety Less side effects, especially thyroid and pulmonary Better than placebo in reducing AF, but no good head-head trials May increase death in CHF patients
22 ACC guidelines 4 rhythm control ACC/AHA/ESC 2006 AF rhythm-control guidelines Maintenance of SR No (or minimal) heart disease Hypertension CAD HF Flecainide Propafenone Sotalol Substantial LVH No Yes Dofetilide Sotalol Amiodarone Dofetilide Amiodarone Dofetilide Catheter ablation Amiodarone Catheter ablation Amiodarone Dofetilide Flecainide Propafenone Sotalol Catheter ablation Amiodarone Catheter ablation Catheter ablation Fuster V et al. Circulation. 2006;114:e257-e354.
23 Pulmonary vein ablation In symptomatic patients requiring rhythm control, if at least 1 antiarrhymic has been ineffective or not tolerated->rfa AF is often triggered by ectopic beats/foci originating from PV Isolating PV by RFA prevents many of these triggers from entering the atria TEE to exclude appendage clots, transseptal puncture
24 Pulmonary vein ablation More effective than drugs in reducing AFib Even after success, should continue anticoagulation 30% require more than 1 procedure Most effective for paroxysmal rather than chronic AF
25 Catheter ablation vs antiarrhythmic drug therapy for AF Cath ablation vs adt N = 432 with AF; Meta-analysis of 4 randomized clinical trials Source ADT more effective CPVA more effective Risk ratio (95% CI) % Weight Pappone et al, ( ) 37.5 Stabile et al, ( ) 18.1 Wazni et al, ( ) 22.0 Krittayaphong et al, ( ) 22.4 Overall (95% CI) 3.73 ( ) Risk ratio ADT = antiarrhythmic drug therapy CPVA = circumferential pulmonary vein ablation Noheria A et al. Arch Intern Med. 2008;168:581-6.
26 A4 study: Catheter ablation vs antiarrhythmic drug therapy for AF A4 cath abl vs adt N = 112 with paroxysmal AF resistant to 1 AAD Freedom 60.0 from recurrent AF (%) Logrank P < RF Follow-up (days) ADT RF = radiofrequency catheter ablation Jaïs P et al. Circulation. 2008;118:
27 Worldwide survey of catheter ablation World survey of RFA N = 8745 with AF treated at 90 centers 12,830 procedures, with 27% of patients undergoing >1 procedure 6% major complication rate 4 deaths (0.05%) 107 tamponade (1.22%) 20 strokes (0.28%) 47 TIA (0.66%) 94 PV stenosis (1.3%) Cappato R et al. Circulation. 2005;111:
28 US US experience with catheter RFA ablation N = 517 with AF undergoing catheter ablation treated at 1 US institution 641 procedures 32 major complications (5%) 7 CVA (1.1%) 8 cardiac tamponade (1.2%) 1 PV occlusion (0.16%) 11 vascular injury (1.7%) No deaths or esophageal injury Complication rate 9% 1 st 100 patients, 4% thereafter Predictors of complications Female gender Age >70 years Spragg DD et al. J Cardiovasc Electrophysiol. 2008;19:
29 Complications of RFA Formation of atrio-esophageal fistula Rare Often fatal Occurs with more extensive LA ablations
30 Complications of RFA Pyloric spasm & gastric hypomotility Occurred 4/367 patients Injury to vagus nerve surrounding esophagus Post ablation indigestion is common? if related to transient nerve dysfunction
31 Atrial Fibrillation Recurrence AF recurs in 35% within 2 weeks (early) May be transient, related to pericarditis Short term use of anti-arrhythmics for 2-3 months 25% may undergo more than 1 ablation Atrial Flutter may occur due to new reentrant circuits created by RFA scar
32 HRS/EHRA/ECAS Expert Consensus Statement: Indications Consensus for catheter statement ablation of AF Indications Symptomatic AF refractory or intolerant to 1 Class 1 or 3 antiarrhythmic drug Selected symptomatic patients with HF and/or EF Should not be considered as 1 st line therapy, except in rare clinical situations Repeat procedures should be delayed for 3 months, if symptoms can be controlled with medical therapy Calkins H et al. Heart Rhythm. 2007;4:
33 Possible upstream treatments and mechanisms Upstream for treatments AF prevention ACEIs/ARBs Statins Glucocorticoids Omega-3 fatty acids Physical activity Inflammation Oxidative stress RAAS activity Endothelial function Autonomic nervous system activity Vascular stability Atrial remodeling Stabilize left atrial endocardium Atrial fibrillation Courtesy of CJ Pepine, MD.
34 AF prevention w RAAS Trials of RAAS inhibition in AF prevention Favors treatment Favors control ACEIs CAPP GISSI HOPE SOLVD STOP-H2 TRACE Ueng Van den Berg Subtotal ARBs CHARM LIFE Madrid ValHeFT Subtotal Total Captopril Lisinopril Ramipril Enalapril Enalapril Trandolapril Enalapril Lisinopril Candesartan Losartan Irbesartan Valsartan Subtotal Total RR* (95% CI) *Random-effects model Salehian O et al. Am Heart J. 2007;154: Healey JS et al. J Am Coll Cardiol. 2005;45:
35 Statins in prevention of AF (1 st episode or AF recurrence) Statins Study Statin Control or subcategory n/n n/m Favors treatment Favors control MIRACL 93/ /1548 Tveit 18/51 17/51 Dernellis 14/40 36/40 ARMYDA 3 35/101 56/99 Chello 2/20 5/20 Ozaydin 3/24 11/24 Total (95% CI) Total events: 165 (Statin), 221 (Control) Test for heterogeneity: Chi 2 = 29.47, df = 5 (P < ), I 2 = 83.0% Test for overall effect: Z = 2.35 (P = 0.02) Not assessed in this meta-analysis: Degree of LDL-C Statin dose OR (random) 95% CI Fauchier L et al. J Am Coll Cardiol. 2008;51:
36 Role of pacemakers Back up pacemakers are indicated for symptomatic brady arrhythmias Asymptomatic patients, while awake pause >3.0 sec escape rate <40
37 Pacemakers to prevent A Fib Controversial evidence-class III Not indicated unless pacemaker appropriate for other reasons Pace above baseline rate, reducing atrial refractoriness and prevent sinus pauses Recognize A Fib episodes, algorithm to provide rapid/burst atrial pacing, may convert back to sinus
38 4 things to remember Most patients with Afib should be considered for long term anticoagulation Rate control strategy is at least as good as rhythm control in reducing CV events Amiodarone is the most efficacious agent in reducing AF burden but has most potential side effects Ablation offers improved AF control in select patients
ΚΑΤΑΛΥΣΗ ΚΟΛΠΙΚΗΣ ΜΑΡΜΑΡΥΓΗΣ. ΥΠΕΡ. Michalis Efremidis MD Second Department of Cardiology Evangelismos General Hospital
ΚΑΤΑΛΥΣΗ ΚΟΛΠΙΚΗΣ ΜΑΡΜΑΡΥΓΗΣ. ΥΠΕΡ. Michalis Efremidis MD Second Department of Cardiology Evangelismos General Hospital Rate control versus Rhythm control for Atrial Fibrillation AFFIRM N Engl J Med 2002;347:1825-33
More information3/25/2017. Program Outline. Classification of Atrial Fibrillation
Alternate Strategies to Antiarrhythmic Therapy: The Role of Ablation Jennifer El Aile, MS, AGPCNP-BC Electrophysiology Nurse Practitioner Clinical Lecturer at the University of Michigan Program Outline
More informationConflicts of Interests
Advances in the Management of Atrial Fibrillation State of the Art in 2013 Overview of AF Stroke risk and anticoagulation Rate control Antiarrhythmic Drug Therapy Catheter ablation Conclusion Hugh Calkins
More informationAblation Should Not Be Used as Primary Therapy for Treatment of Patients with Atrial Fibrillation
Ablation Should Not Be Used as Primary Therapy for Treatment of Patients with Atrial Fibrillation 25 October 2008 Update in Electrocardiography and Arrhythmias Zian H. Tseng, M.D., M.A.S. Assistant Professor
More informationControversies in Atrial Fibrillation and HF
Controversies in Atrial Fibrillation and HF Dr.Yahya Al Hebaishi Cardiac electrophysiology division, PSCC, Riyadh Atrial Fibrillation: Rate or Rhythm? HF and AF: the twin epidemic of cardiovascular disease.
More informationAtrial Fibrillation New Approaches, Techniques, and Technology
New Cardiovascular Horizons 2015 May 28, 2015 New Orleans, Louisiana Atrial Fibrillation New Approaches, Techniques, and Technology State of the Art - - 2015 Richard Abben, M D Director, Cardiac Arrhythmia
More informationAF and arrhythmia management. Dr Rhys Beynon Consultant Cardiologist and Electrophysiologist University Hospital of North Staffordshire
AF and arrhythmia management Dr Rhys Beynon Consultant Cardiologist and Electrophysiologist University Hospital of North Staffordshire Atrial fibrillation Paroxysmal AF recurrent AF (>2 episodes) that
More informationAtrial Fibrillation: Rate vs. Rhythm. Michael Curley, MD Cardiac Electrophysiology
Atrial Fibrillation: Rate vs. Rhythm Michael Curley, MD Cardiac Electrophysiology I have no relevant financial disclosures pertaining to this topic. A Fib Epidemiology #1 Most common heart rhythm disturbance
More informationATRIAL FIBRILLATION: REVISITING CONTROVERSIES IN AN ERA OF INNOVATION
ATRIAL FIBRILLATION: REVISITING CONTROVERSIES IN AN ERA OF INNOVATION Frederick Schaller, DO, MACOI,FACP Adjunct Clinical Professor Touro University Nevada DISCLOSURES I have no financial relationships
More informationInnovations in AF Management
Innovations in AF Management Barry Boilson MD PhD FRCPI boilson.barry@mayo.edu Disclosures Relevant None financial relationship(s) with industry None Off Label Usage None Overview Mechanisms of AF AF as
More informationAtrial fibrillation from prevention to treatment
State of the Art Atrial fibrillation from prevention to treatment Carina Blomström Lundqvist Dept Cardiology, Uppsala University, Sweden AF - from prevention to treatment 1. Upstream preventive therapy
More informationGeriatric Grand Rounds
Geriatric Grand Rounds Tuesday, April 13, 21 12: noon Dr. Bill Black Auditorium Glenrose Rehabilitation Hospital In keeping with Glenrose Rehabilitation Hospital policy, speakers participating in this
More informationAF Today: W. For the majority of patients with atrial. are the Options? Chris Case
AF Today: W hat are the Options? Management strategies for patients with atrial fibrillation should depend on the individual patient. Treatment with medications seems adequate for most patients with atrial
More informationSupplementary Online Content
Supplementary Online Content Morillo CA, Verma A, Connolly SJ, et al. Radiofrequency ablation vs antiarrhythmic drugs as first-line Treatment of Paroxysmal Atrial Fibrillation (RAAFT-2): a randomzied clinical
More informationRecent observations have focused attention on the PVs as a source of ectopic activity i determining i AF
Atrial Fibrillation in 2010 Panos Vardas Professor of Cardiology President of EHRA Atrial Fibrillation Pathophysiology of AF Triggers Recent observations have focused attention on the PVs as a source of
More informationAre Drugs Better? Dr Mauro Lencioni. Drugs or ablation as first line treatment for AF? Consultant Cardiologist & Electrophysiologist
Are Drugs Better? Drugs or ablation as first line treatment for AF? Dr Mauro Lencioni Consultant Cardiologist & Electrophysiologist The Philosophical Issue What do we mean by Better? Outcome measures Measurement
More informationAF :RHYTHM CONTROL BY DR-MOHAMMED SALAH ASSISSTANT LECTURER CARDIOLOGY DEPARTMENT
AF :RHYTHM CONTROL BY DR-MOHAMMED SALAH ASSISSTANT LECTURER CARDIOLOGY DEPARTMENT 5-2014 Atrial Fibrillation therapeutic Approach Rhythm Control Thromboembolism Prevention: Recommendations Direct-Current
More informationUnderstanding Atrial Fibrillation Management. Roy Lin, MD
Understanding Atrial Fibrillation Management Roy Lin, MD Disclosure None Definition of atrial fibrillation Atrial fibrillation is a supraventricular tachyarrhythmia characterized by uncoordinated atrial
More informationHalf Moon Bay Treatment of Atrial Fibrillation. Dr. Roger A. Winkle MD. Silicon Valley Cardiology, PAMF, Sutter Health Sequoia Hospital
Half Moon Bay 2018 Treatment of Atrial Fibrillation Dr. Roger A. Winkle MD Silicon Valley Cardiology, PAMF, Sutter Health Sequoia Hospital Disclosures: Investor Farapulse Things a Primary Care Doctor Should
More informationControversies with regard to 'upstream therapy of atrial fibrillation
Controversies with regard to 'upstream therapy of atrial fibrillation Barbara Casadei Department of Cardiovascular Medicine John Radcliffe Hospital University of Oxford No conflict of interest to declare
More informationLong-Term Outcome and Risks of Catheter Ablation for Atrial Fibrillation
Long-Term Outcome and Risks of Catheter Ablation for Atrial Fibrillation Carlo Pappone, MD, PhD, FACC EP Director, Villa Maria Hospital Group How many times AF can increase mortality DO MORTALITY REALLY
More informationRate and Rhythm Control of Atrial Fibrillation
Rate and Rhythm Control of Atrial Fibrillation April 21, 2017 춘계심혈관통합학술대회 Jaemin Shim, MD, PhD Arrhythmia Center Korea University Anam Hospital Treatment of AF Goal Reducing symptoms Preventing complication
More informationJay Simonson, MD, FACC, FHRS Medical Director, Cardiac Electrophysiology Park Nicollet Heart and Vascular Center
Jay Simonson, MD, FACC, FHRS Medical Director, Cardiac Electrophysiology Park Nicollet Heart and Vascular Center A-Fib Facts Yes, you may be able to blame your parents It is more of a nuisance than a
More informationIndex. cardiology.theclinics.com. Note: Page numbers of article titles are in boldface type.
Index Note: Page numbers of article titles are in boldface type. A AADs. See Antiarrhythmic drugs (AADs) ACE inhibitors. See Angiotensin-converting enzyme (ACE) inhibitors ACP in transseptal approach to
More informationAtrial Fibrillation Ablation: in Whom and How
Update on Consensus Statement on Management of Atrial Fibrillation: EHRA 2012 Atrial Fibrillation Ablation: in Whom and How Update of HRS/EHRA AF/ECAS Ablation Document 2012 Anne M Gillis MD FHRS Professor
More informationIn Whom and When Should Atrial Fibrillation Ablation be Considered?
In Whom and When Should Atrial Fibrillation Ablation be Considered? Christian de Chillou, MD, PhD Department of Cardiology University Hospital Nancy, France ESC 2010 Stockholm, August 30. 2010 2 In Whom?
More informationAtrial Fibrillation 2009
Atrial Fibrillation 2009 Michael Glikson, MD Director of Pacing & Electrophysiology Leviev Heart Center Sheba medical Center Sheba Medical Center Tel Hashomer The Leviev Heart Center Rhythm vs rate control
More informationBasics of Atrial Fibrillation. By Mini Thannikal NP-BC Mount Sinai St Luke s Hospital New York, NY
Basics of Atrial Fibrillation By Mini Thannikal NP-BC Mount Sinai St Luke s Hospital New York, NY Atrial Fibrillation(AF) is a supraventricular tachyarrhythmia characterized by uncoordinated atrial activation
More informationPatient Presentation
Update on Current Perspectives and Management Options for Atrial Fibrillation Burr Hall, M.D. March 20, 2015 Patient Presentation 72 year old active male farmer and tow truck operator from Hemlock, NY
More informationAtrial Fibrillation Cases. Dr Paul Broadhurst Consultant Cardiologist
Atrial Fibrillation Cases Dr Paul Broadhurst Consultant Cardiologist November 2011 Mr TH age 72 Routine medical for hypertension check Denies any symptoms despite close questioning PMH: hypertension, MI,
More informationMANAGING ATRIAL FIBRILLATION: BEYOND ANTICOAGULATION December 9, 2017
MANAGING ATRIAL FIBRILLATION: BEYOND ANTICOAGULATION December 9, 2017 1 Faculty Disclosure Faculty: Peter Leong-Sit MSc, MD, FRCPC, FHRS Associate Professor, Western University Cardiologist, London Heart
More informationDisclosures. Managing Atrial Fibrillation in Atrial Fibrillation: A Growing Problem. Objectives. Atrial Fibrillation: Prevalence Estimates
Managing Atrial Fibrillation in 2010 Jennifer Cummings, MD FACC Director, Cardiac Electrophysiology Akron General Medical Center Disclosures Company Boston Scientific St. Jude Medical Medtronic Sanofi-Aventis
More informationAtrial Fibrillation and the NOAC s. John Raymond MS, PA-C, MHP February 10, 2018
Atrial Fibrillation and the NOAC s John Raymond MS, PA-C, MHP February 10, 2018 Pathogenesis EPIDEMIOLOGY Arrhythmia-related hospitalisations in the US Ventricular fibrillation 2% Atrial fibrillation 34%
More informationCurrent Guideline for AF Treatment. Young Keun On, MD, PhD, FHRS Samsung Medical Center Sungkyunkwan University School of Medicine
Current Guideline for AF Treatment Young Keun On, MD, PhD, FHRS Samsung Medical Center Sungkyunkwan University School of Medicine Case 1 59 year-old lady Sudden palpitation and breathlessness for 12 hours
More informationABLATION OF CHRONIC AF
ABLATION OF CHRONIC AF A PISAPIA ST JOSEPH HOSPITAL MARSEILLE MEET 2008 Atrial Fibrillation The most common significant heart rhythm disturbance Incidence increases with age and the development of structural
More informationCatheter Ablation for AF: Patients, Procedures, Outcomes
Catheter Ablation for AF: Patients, Procedures, Outcomes John Sapp Director Heart Rhythm, QEII Health Sciences Centre Professor of Medicine, Dalhousie University Atrial Fibrillation Atrial Fibrillation
More informationAtrial Fibrillation: Beyond the AFFIRM trial
Atrial Fibrillation: Beyond the AFFIRM trial Daniel J. Cantillon MD FACC FHRS Cardiac Electrophysiology and Pacing Assistant Professor, Lerner College of Medicine Cleveland Clinic, Heart & Vascular Institute
More informationIs cardioversion old hat? What is new in interventional treatment of AF symptoms?
Is cardioversion old hat? What is new in interventional treatment of AF symptoms? Joseph de Bono Consultant Electrophysiologist University Hospitals Birmingham Atrial Fibrillation (AF) Affects 2% of the
More informationManagement of atrial fibrillation a holistic view - Prof. Dr. Martin Borggrefe Mannheim
a holistic view - Prof. Dr. Martin Borggrefe Mannheim Patients with atrial fibrillation (millions) 16 14 12 10 8 6 4 2 0 Management of atrial fibrillation Expected prevalence of apparent AF 5,1 5,1 5,9
More informationInvasive and Medical Treatments for Atrial Fibrillation. Thomas J Dresing, MD Section of Electrophysiology and Pacing Cleveland Clinic
Invasive and Medical Treatments for Thomas J Dresing, MD Section of Electrophysiology and Pacing Cleveland Clinic Disclosures Fellow s advisory panel for St Jude Medical Speaking honoraria from: Boston
More informationANTIPAF Angiotensin II Antagonist in Paroxysmal Atrial Fibrillation Trial
European Society of Cardiology Hotline Stockholm - Zone K 31 st August 2010 Placebo ARB Kumagai K, et al. JACC 2003 Discussant ANTIPAF Angiotensin II Antagonist in Paroxysmal Atrial Fibrillation Trial
More informationΕπιπλοκές κατάλυσης πνευµονικών φλεβών
Επιπλοκές κατάλυσης πνευµονικών φλεβών Παναγιώτης Ιωαννίδης Διευθυντής Τµήµατος Αρρυθµιών & Επεµβατικής Ηλεκτροφυσιολογίας Βιοκλινικής Αθηνών ΣΕΜΙΝΑΡΙΑ ΟΜΑΔΩΝ ΕΡΓΑΣΙΑΣ Ιωάννινα, 27-2-2015 Solving an equation
More informationΚατάλυση παροξυσμικής κολπικής μαρμαρυγής Ποια τεχνολογία και σε ποιους ασθενείς; Χάρης Κοσσυβάκης Καρδιολογικό Τμήμα Γ.Ν.Α. «Γ.
Κατάλυση παροξυσμικής κολπικής μαρμαρυγής Ποια τεχνολογία και σε ποιους ασθενείς; Χάρης Κοσσυβάκης Καρδιολογικό Τμήμα Γ.Ν.Α. «Γ. ΓΕΝΝΗΜΑΤΑΣ» Rhythm control antiarrhythmic drugs vs catheter ablation Summary
More informationFibs and Flutters: The Heart of the Matter
Fibs and Flutters: The Heart of the Matter Anita Ralstin, CNP By the Numbers Atrial Fibrillation Hospital Discharges /quarter for 2012 -- 116,500 Average Length of Stay 4 days Projected that 20% of those
More informationDipen Shah Cardiology Service, University Hospitals, Geneva Switzerland
Dipen Shah Cardiology Service, University Hospitals, Geneva Switzerland Disclosures Research Grants: Biosense Webster, St. Jude, Bard, Endosense, Biotronik Speakers Honoraria: Biosense Webster, Endosense,
More informationAF in Andrew Staniforth. Mayo Course March 2014
AF in 2014 Andrew Staniforth Mayo Course March 2014 European Heart Journal 2010; 31: 2369 2429 www escardio.org/guidelines Q1 (Indications for anticoagulation) For stroke prevention in AF, which of the
More informationUC SF. Division of General Internal Medicine UNIVERSITY OF CALIFORNIA SAN FRANCISCO, DIVISION OF HOSPITAL MEDICINE
Updates in the Management of Atrial Fibrillation Margaret C. Fang, MD, MPH Associate Professor of Medicine UCSF Division of Hospital Medicine Medical Director, Anticoagulation Clinic UC SF Division of
More informationAtrial Fibrillation Etiologies and Treatment. Shawn Liu Learner Centered Learning Goal
Atrial Fibrillation Etiologies and Treatment Shawn Liu Learner Centered Learning Goal Pathophysiology Defined by the absence of coordinated atrial systole Results from multiple reentrant electrical waves
More informationCatheter Ablation: Atrial fibrillation (AF) is the most common. Another Option for AF FAQ. Who performs ablation for treatment of AF?
: Another Option for AF Atrial fibrillation (AF) is a highly common cardiac arrhythmia and a major risk factor for stroke. In this article, Dr. Khan and Dr. Skanes detail how catheter ablation significantly
More informationAtrial Fibrillation and Heart Failure: A Cause or a Consequence
Atrial Fibrillation and Heart Failure: A Cause or a Consequence Rajat Deo, MD, MTR Assistant Professor of Medicine Division of Cardiology, Electrophysiology Section University of Pennsylvania November
More informationThe 5 Most Important Things You Need to Know About Atrial Fibrillation. John D. Day, MD
The 5 Most Important Things You Need to Know About Atrial Fibrillation John D. Day, MD Disclosures Consulting with St. Jude Medical, Boston Scientific, and Biotronik The 5 Most Important Things You Need
More information2015 Atrial Fibrillation Therapy Meds, Shock, or Ablate? D. Scott Kirby MD, FACC Cardiac Electrophysiologist
2015 Atrial Fibrillation Therapy Meds, Shock, or Ablate? D. Scott Kirby MD, FACC Cardiac Electrophysiologist Todays Objectives Atrial Fibrillation evaluation and treatment from an EP perspective Multimodal
More informationAtrial Fibrillation Topics for Today. Clinical Controversies Management of Atrial Fibrillation. Atrial Fibrillation in the ER Topics for Today
Clinical Controversies Management of Atrial Fibrillation Yerem Yeghiazarians, M.D. Associate Professor of Medicine Leone-Perkins Family Endowed Chair in Cardiology Atrial Fibrillation Topics for Today
More informationCost and Prevalence of A fib. Atrial Fibrillation: Guideline Directed Treatment. Prevalence of A Fib. Risk Factors for A Fib. Risk Factors for A Fib
Atrial Fibrillation: Guideline Directed Treatment Melissa Wendell, FNP-C, MSN Heart Failure - Lead Nurse Practitioner, Aspirus Wausau Hospital and Aspirus Cardiology Cost and Prevalence of A fib 33.5 million
More informationSupplementary Online Content
Supplementary Online Content Verma A, Champagne J, Sapp J, et al. Asymptomatic episodes of atrial fibrillation before and after catheter ablation: a prospective, multicenter study. JAMA Intern Med. Published
More informationProgression of atrial fibrillation: can we prevent it? Early catheter ablation will stop progression of atrial fibrillation pro
Progression of atrial fibrillation: can we prevent it? Early catheter ablation will stop progression of atrial fibrillation pro Jerónimo Farré MD, Madrid, ES AF: the kingdom of wishful thinking In AF we
More informationThe Emerging Atrial Fibrillation Epidemic: Treat It, Leave It or Burn It. Chandra Kumbar MD FACC FHRS The Heart Group, Evansville IN
The Emerging Atrial Fibrillation Epidemic: Treat It, Leave It or Burn It Chandra Kumbar MD FACC FHRS The Heart Group, Evansville IN Disclosures Consultant Advisory Board, Medtronic Atrial fibrillation
More informationSamer Nasr, M.D. Mount Lebanon Hospital.
Samer Nasr, M.D. Mount Lebanon Hospital. Lone atrial fibrillation: Younger than 60 years old. No clinical or echo evidence of cardiopulmonary disease. Favorable prognosis. Thromboembolism usually not
More informationOut with the old, in with The 2010 Atrial Fibrillation Guidelines
Out with the old, in with The 2010 Atrial Fibrillation Guidelines Kseniya Chernushkin B.Sc.(Pharm.), VCH/PHC Pharmacy Resident Mary Elliot B.Sc.(Pharm.), VCH/PHC Pharmacy Resident March 22, 2011 Outline
More information5/5/2010. World incidence 720, 000 new cases / year. World prevalence 5.55 million AF prevalence increasing with aging of population
Atrial Fibrillation: Guidelines through clinical cases and 2010 updates Samy Claude ELAYI Cardiac Clinical Pacing and Electrophysiology UK World incidence 720, 000 new cases / year World prevalence 5.55
More informationWhat s new in my specialty?
What s new in my specialty? Jon Melman, MD Heart Rhythm Specialists McKay-Dee Hospital some would say some would say my specialty 1 some would say my specialty First pacemaker 1958 some would say my specialty
More informationPLEASE TAKE A MOMENT TO COMPLETE THE PRE-TEST
PLEASE TAKE A MOMENT TO COMPLETE THE PRE-TEST Atrial Fibrillation Affects 2 to 5 million US patients 1% of population Associated with older age and chronic heart disease, especially HF Comorbidities AF
More informationThe Role of ACEI and ARBs in AF prevention
The Role of ACEI and ARBs in AF prevention Dr. Sameh Shaheen MD, FESC Prof. of cardiology Ain-Shams university Time course of atrial substrate remodeling in relation to the clinical appearance of AF and
More information심방세동과최신항응고요법 RACE II AFFIRM 항응고치료는왜중요한가? Rhythm control. Rate control. Anticoagulation 남기병 서울아산병원내과. Clinical Impact of Atrial Fibrillation
소강당 심방세동과최신항응고요법 남기병 서울아산병원내과 Clinical Impact of Atrial Fibrillation QoL Hospitalization Stroke CHF Mortality 항응고치료는왜중요한가? Rhythm control Rate control Anticoagulation JACC Vol. 38, No. 4, 2001 AFFIRM RACE
More informationModern management of atrial fibrillation, from blood pressure control to anticoagulation
Modern management of atrial fibrillation, from blood pressure control to anticoagulation Adel Khalifa S. Hamad, BMS, MD, FRCP(Canada) Consultant Cardiologist & Interventional Cardiac Electrophysiologist
More informationAtrial Fibrillation: It s More than a Rhythm
Atrial Fibrillation: It s More than a Rhythm Relax and Learn at the Farm 2013 DNP, RN, CCNS, CCRN-CMC, CHFN Cardiovascular Nursing Education Associates 1 The Quality of a Person s Life is Directly Proportional
More informationAtrial Fibrillation: Guidelines through clinical cases and 2010 updates
Atrial Fibrillation: Guidelines through clinical cases and 2010 updates Samy Claude ELAYI Cardiac Clinical Pacing and Electrophysiology World incidence 720, 000 new cases / year World prevalence 5.5 million
More informationModest Medtronic. Modest Boehringer Ingelheim
Adults With AF (millions) Modest Medtronic Modest Boehringer Ingelheim Changing Modalities of Care for Atrial Fibrillation Jill Repoley MSN, CRNP, CCDS, CEPS, FHRS 7 6 5 4 3 2 1 2.08 2.26 2.44 2.66 2.94
More informationAtrial Fibrillation and Heart Failure: Rate vs. Rhythm Control Time for Re-evaluation
Atrial Fibrillation and Heart Failure: Rate vs. Rhythm Control Time for Re-evaluation ANIL K. BHANDARI, M.D, Director, Electrophysiology and EPS Fellowship Program Good Samaritan Hospital/ Harbor UCLA
More informationPrevention of Atrial Fibrillation and Heart Failure in the Hypertensive Patient
Prevention of Atrial Fibrillation and Heart Failure in the Hypertensive Patient The Issue of Primary Prevention of A.Fib. (and Heart Failure) and not the Prevention of Recurrent A.Fib. after Electroconversion
More informationThe 5 Most Important Things You Need to Know About Atrial Fibrillation. John D. Day, MD Director, Intermountain Heart Rhythm Specialists
The 5 Most Important Things You Need to Know About Atrial Fibrillation John D. Day, MD Director, Intermountain Heart Rhythm Specialists None Disclosures The 5 Most Important Things You Need to Know About
More informationA Cryo Anatomical Procedure to Everyone? Saverio Iacopino, FACC, FESC
A Cryo Anatomical Procedure to Everyone? Saverio Iacopino, FACC, FESC AF Clinical/Referral Challenge Asymptomatic 40% 3 Rx Effective 30% Failed Rx Ablation Atrial fibrillation (AF) is the most common Candidate
More informationInterventional solutions for atrial fibrillation in patients with heart failure
Interventional solutions for atrial fibrillation in patients with heart failure Advances in Cardiovascular Arrhythmias Great Innovations in Cardiology Matteo Anselmino, MD PhD Division of Cardiology Department
More informationRebuttal. Jerónimo Farré MD 2010
Rebuttal 1.We do not know what are the types of AF in which ablation is worthless or most effective 2.Waiting implies to consider the ablation at an older age and when the duration of the history of AF
More informationThe unholy trinity of stroke risk: Sleep Apnea, Obesity, and Hypertension
The unholy trinity of stroke risk: Sleep Apnea, Obesity, and Hypertension P. Timothy Pollak, MD, PhD Professor of Medicine, Cardiac Sciences & Pharmacology A Case of Atrial Fibrillation 62 y man referred
More informationDysrhythmias 11/7/2017. Disclosures. 3 reasons to evaluate and treat dysrhythmias. None. Eliminate symptoms and improve hemodynamics
Dysrhythmias CYDNEY STEWART MD, FACC NOVEMBER 3, 2017 Disclosures None 3 reasons to evaluate and treat dysrhythmias Eliminate symptoms and improve hemodynamics Prevent imminent death/hemodynamic compromise
More informationAtrial Fibrillation Ablation in Patients with Heart Failure
Atrial Fibrillation Ablation in Patients with Heart Failure Eleftherios M. Kallergis, MD, PhD, FESC Cardiology Department, Heraklion University Hospital Since auricular fibrillation so often complicates
More informationAtrial Fibrillation and Common Supraventricular Tachycardias. Sunil Kapur MD
Atrial Fibrillation and Common Supraventricular Tachycardias Sunil Kapur MD Cardiac Electrophysiology Brigham and Women s Hospital Instructor, Harvard Medical School No disclosures Cardiac Conduction:
More information» A new drug s trial
» A new drug s trial A placebo-controlled, double-blind, parallel arm Trial to assess the efficacy of dronedarone 400 mg bid for the prevention of cardiovascular Hospitalization or death from any cause
More informationArrhythmias (I) Supraventricular Tachycardias. Disclosures
Arrhythmias (I) Supraventricular Tachycardias Amy Leigh Miller, MD, PhD Cardiovascular Electrophysiology, Brigham & Women s Hospital Disclosures None Short R-P Tachycardia REGULAR with 1:1 P/R relationship
More informationTreating Atrial Fibrillation. Richard Schilling. St Bartholomew's Hospital, Queen Mary s University of London
Treating Atrial Fibrillation Richard Schilling St Bartholomew's Hospital, Queen Mary s University of London AF burden Framingham Lifetime risk of developing AF = 25% Mortality: SMR =1.9 1.5 NHS audit 1%
More informationPractical Rate and Rhythm Management of Atrial Fibrillation
Practical Rate and Rhythm Management of Atrial Fibrillation pocket guide UPDATED FEBRUARY 2013 Adapted from the ACCF/AHA/HRS 2011 Focused Updates Incorporated into the ACC/AHA/ESC Guidelines for the Management
More informationCatheter Ablation for Atrial Fibrillation: Patient Selection and Outcomes
Catheter Ablation for Atrial Fibrillation: Patient Selection and Outcomes Francis Marchlinski, MD Richard T and Angela Clark President s Distinguished Professor Director Cardiac Electrophysiolgy University
More informationIndicatie voor ablatie bij voorkamerfibrillatie. Andrea Sarkozy Cardiologie Universitair Ziekenhuis Antwerpen
Indicatie voor ablatie bij voorkamerfibrillatie Andrea Sarkozy Cardiologie Universitair Ziekenhuis Antwerpen Definition and Classification of AF - Practical aspects Classification of AF Paroxysmal, persistent,
More informationSaudi Heart Association February 22, 2011
Pharmacological Therapy of Atrial Fibrillation: Recent Advances Dr Martin Green Professor of Medicine (Cardiology) University of Ottawa Saudi Heart Association February 22, 2011 Atrial Fibrillation Drugs
More informationCatheter Ablation for Treatment of Atrial Fibrillation 2010 and Beyond
Catheter Ablation for Treatment of Atrial Fibrillation 2010 and Beyond John M. Miller, MD Professor of Medicine Indiana University School of Medicine Director, Clinical Cardiac Electrophysiology Krannert
More informationWhat s New in the AF Guidelines
Impact on New AF Guidelines on Heart Failure Management Gothenburg - May 22 nd 2011 Europace (2010) 12, 1360-420 http://europace.oxfordjournals.org JACC (2011) 57, 223-42 http://www.cardiosource.org What
More informationAtrial fibrillation and advanced age
Atrial fibrillation and advanced age Prof. Fiorenzo Gaita Director of the Cardiology School University of Turin, Italy Prevalence of AF in the general population Prevalence and age distribution in patients
More informationPossible clinical and hemodynamic predictors of atrial fibrillation recurrence after catheter ablation
Samara Regional Center of Cardiosurgery Possible clinical and hemodynamic predictors of atrial fibrillation recurrence after catheter ablation S. Dolginina, S. Garkina, S. Khokhlunov, D. Duplyakov Russia
More informationHow Do I Balance Bradycardia with Rate Control in Atrial Fibrillation?
How Do I Balance Bradycardia with Rate Control in Atrial Fibrillation? Thang Nguyen MD FRCPC Assistant Professor Section of Cardiology Department of Internal Medicine University of Manitoba Objectives
More informationAtrial Fibrillation: Interventional Approaches
Atrial Fibrillation: Interventional Approaches Tyler Taigen, MD Eric Espinal, MD Discussion Outline Review current treatment of atrial fibrillation Pathophysiology Risk assessment and treatment to reduce
More informationLong Standing Persistent AF ; CPVI is enough for it
Long Standing Persistent AF ; CPVI is enough for it Kee-Joon Choi, MD University of Ulsan College of Medicine Asan Medical Center, Seoul, Korea Boston AF Symposium 2012 In a patient undergoing AF ablation
More informationRate Control versus Rhythm Control in NSTEMI
Rate Control versus Rhythm Control in NSTEMI Gulmira Kudaiberdieva, MD, FESC Adana, Turkey Conflict of interest: None to declare Istanbul - 2012 OUTLINE Significance of AF in ACS Prognostic value of AF
More informationFibrillazione atriale e scompenso: come interrompere il circolo vizioso.
Alessandria, September 23 th 2017 Fibrillazione atriale e scompenso: come interrompere il circolo vizioso. Professor Fiorenzo Gaita Chief of the Cardiovascular Department Città della Salute e della Scienza
More informationCombined catheter ablation and left atrial appendage closure as a. treatment of atrial fibrillation
Combined catheter ablation and left atrial appendage closure as a hybrid procedure for the treatment of atrial fibrillation Giulio Molon, MD FACC, FESC, Fellow ANMCO Card Dept, S.Cuore hospital Negrar
More informationIncidence and Disease Burden. Role of Catheter ablation Outcomes Data
Management of Atrial Fibrillation Nitish Badhwar, MD, FACC University of California, San Francisco Risk Appraisal Forum April 23, 2010 Incidence and Disease Burden Drug therapy Role of Catheter ablation
More informationWho Gets Atrial Fibrilla9on..?
Birmingham October 20 th 2013 AFA Pa9ents Day Symptoma9c Atrial Fibrilla9on What therapies are available? GENERAL BACKGROUND Andrew Grace Papworth Hospital and University of Cambridge Consultant: Medtronic
More informationAtrial Fibrillation What are the Options in 2016?
Atrial Fibrillation What are the Options in 2016? David Spragg, MD, FHRS Johns Hopkins Hospital Cardiovascular Disease Management October, 2016 Disclosures Consulting, Biosense Webster Overview What is
More informationNEWLY DETECTED ATRIAL FIBRILLATION. Edgar S. Carell, M.D. Director, Vascular Medicine Clinic West Suburban Cardiology
NEWLY DETECTED ATRIAL FIBRILLATION Edgar S. Carell, M.D. Director, Vascular Medicine Clinic West Suburban Cardiology 68 y/o woman complains of - generalized fatigue - mild DOE - never eats but keeps gaining
More informationState of the Art Management on Atrial Fibrillation in Monica Lo, MD, FACC, FHRS April 15, 2016
State of the Art Management on Atrial Fibrillation in 2016 Monica Lo, MD, FACC, FHRS April 15, 2016 Scope of the Problem More than 30 million people worldwide 1 5 million new cases each year 1 in 4 lifetime
More information