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2 :,,,» :,,, 2-,,, «-,,» : : ,.,, 83, uchsovet@bsmu.by, ,,..
3 1 ( ) [.., 2003;.., 2008; Finegold J. A., 2013]. ( ).., 2004;.., 2011] % [.., 2010].,, [.., 2011]., - ( ) [Lifton R. P., 2001;.., 2003; Naber C. K., 2004; Kearney P. M., 2005;.., 2010].,.,, [Castellano M., 1996;.., 1997;.., 1998]., [Voitovich A. M., 2003; Heux S., 2004].,. ( ),» «-,» ( );
4 » ( ); «, ex-vivo/in-vitro ACE MTHFR» ( ).. 4, « » ). :, ,. 4.. : 150. :,, -.,,.
5 3,,,., AGT, 1- II AGTR1, REN, MTHFR) 235 AGT. AGT. MTHFR, MT AGT DD ACE.,. ( ) AGT, AA REN, II ACE.,,,,.., 1. :,»,,,»,,,»,,,,»,,,» AGT,. 3.. MTHFR, MT AGT DD ACE
6 4, AGT, AA REN, II. 4. AGT,,,,.,,,,.,,.,,,.,,,. [1] [13, 14, 16] 95%. [3, 4, 5, 6, 7, 8, 9], [10, 11, 12] [15] 85%. [2, 5, 6], [12] [17] 60%. [4, 5] 95% (, 2012); «-» (, 2013);
7 5, (, 2013); «:,,», 2013); 67- «2013» (, 2013);, (, 2014); «2014», 2014);» (, 2014); «8-2015:,» (,, 2015). «3-».,. 16 : 5,. 18 (2,1 ), 6, 5, ( ),,, 5,,. 18, (134, 111 ), 16.
8 ( ). ( ) Microlife ( ),. :, II III., 2-3. :,,,,,,,,. ( ) ,,. (n=150) (n=62). ( ) 30,4 (28,4 33,1) 2, 27,1 (25,0 29,0) 2, 97,5 (88,0 106,0), 85,0 (80,0 93,0) ( <0,05). ( ) (. ) 120,0 (120,0 120,0).., (. ) 80,0 (80,0 80,0).., :. 180,0 (160,0 200,0)..,. 100,0 (100,0 110,0)..,. 140,0 (140,0 150,0)..,. 100,0 (100,0 110,0)..,. 130,0 (120,0 130,0)..,. 80,0 (80,0 90,0)..).
9 7 61,3%, 59,3%, 36,7% ( 2 =4,0; =0,045), OR=1,86 (95% CI: 1,58 2,18). ( ), ( ). [.., 2000].. - :,,,, FC 500 (Beckman Coulter, )., ( ) ( ). : MTHRF (C677T, rs ), (I/D, rs4340), AGT (M235T, rs699), 1- II AGTR1 (A1166C, rs5186), REN (G18-83A).» [.., 2000] [Lasarus R. S., Folkman S.,.., 2010]. Excel, Statistica 10.0, SPSS 17. (t), (U) 3., ( 2 ). (r).
10 8, 95% ( <0,05). «Calculator for confidence intervals of odds ratio»., (OR), ( ). ROC-. (n=131) (n=51). 1 55,8 (48,7 61,6), 51,1 (44,0 58,1); <0,05).»» ( 56,4 (50,7 62,2), 61,0 (55,3 66,8); <0,01). 3 ( 57,3 (50,2 61,4), 63,5 (57,3 70,6); <0,001).,,. 4 ( 57,1 (51,8 61,53), 50,1 (43,1 56,2); <0,001),,. 5,, ( 40,4 (36,1 47,7), 40,4 (33,2 49,1); >0,05). 1. 1, :,,»,,,»,,,,»,,,»,,.
11 «-» U P ,3 (51,9 66,7) 55,6 (44,4 59,3) 2439,5 <0, ,8 (36,8 52,8) 40,8 (36,8 48,8) 2579,0 <0, ,0 (39,6 54,4) 61,9 (54,4 65,6) 1529,5 <0, ,0 (38,9 55,6) 61,1 (55,6 61,1) 2039,5 <0, ,6(47,6 63,6) 63,6 (55,6 71,6) 2071,0 <0, ,0 (46,0 62,7) 62,7 (56,0 69,3) 2071,5 <0, ,4 (42,4 54,4) 54,4 (46,4 62,4) 2421,5 <0, ,8 (47,4 62,2) 62,2(54,8 65,9) 2096,0 <0, ,3 (53,6 71,4) 50,0 (42,9 53,6) 1237,5 <0, ,4 (43,0 57,8) 46,7 (43,0 50,4) 2504,0 <0, ,5 (51,3 61,0) 44,8 (38,4 54,5) 1962,0 <0, ,7 (34,3 47,4) 47,4 (38,7 56,1) 2370,0 <0, ,2 (43,5 55,0) 43,5 (35,8 47,3) 1844,5 <0, ,4 (47,0 58,1) 47,0 (39,6 50,7) 2212,5 <0, ,1 (33,8 50,4) 50,4 (46,3 58,8) 1882,0 <0,001 :» (65,6±9,6), (61,4±10,7),» (63,2±13,0), (41,4±10,0), (60,3±9,4) ( 1).
12 10 1. : 1. -1, : 1.1, 1.2, 1.3, 1.4, , : 2.1, 2.2, 2.3, 2.4, , : 3.1, 3.2, 3.3, 3.4, , : 4.1, 4.2, 4.3, 4.4, , : 5.1, 5.2, 5.3, 5.4, :» (OR=0,48; 95% CI (0,24 0,97); p<0,05). (OR=2,74; 95% CI (1,11 7,4); p<0,05).
13 AGT,.. 93 (62,0%): 27 (43,5%) ( 2 =6,41; =0,04). ( 2 =6,51, =0,01). ( 2). 2. AGT 2 OR p n=150 n=62 95% CI 0,207 0,274 0,69 0,35 1,37 0,620 0,435 6,41 0,04 2,12 1,16 3,86 0,173 0,290 0, ,02 MT AGT, OR=2,12 (95% CI: 1,16 3,86)., 61,33%, 59,33% 36,7%. AGT, ( 2 =9,37 p<0,01), 2,24, OR=2,24 (95% CI: 1,60 3,13). AGT 2,07 (95% CI: 1,48 2,88). DD 25 2 ), OR=2,16 (95% CI: 0,97 1,74).,
14 12 G1/G0 G2/M. S- 0,24 (0,00 0,60)% 0,35 (0,18 0,93)%, ( =0,029)., r=0,46 (p<0,001). ( 0,19±0,10, 0,16±0,06, <0,001). : 0,29±0,13, 0,25±0,08 ( <0,001) 2). 2.. I/D (U=736,0; =0,012) (p<0,05), G1/G0 (U=793,0; =0,044). MTHFR.
15 13 (U=977,0; =0,019). AGT c S- (U=785,0; =0,0065).,, S-., AGTR1 (U=789,0; =0,02).. AGT (U=118,0; =0,003). REN (U=25,0; =0,042). II (U=128,0; =0,03)., REN II., : (,,,»,, ( <0,001)),,, AGT. ( 3). 3., B S.D. p Exp (B) ( 1) 0,562 0,105 28,625 0,000 1,755, ( 2) 0,144 0,043 11,425 0,001 1,155 ( 3) 1,251 0,540 5,372 0,020 3,493 AGT ( 4) 1,301 0,535 5,906 0,015 3,674 1 ( 5) 0,066 0,029 5,054 0,025 1,068 2 ( 6) -0,156 0,036 18,210 0,000 0,856 4 ( 7) 0,100 0,033 9,287 0,002 1,106
16 14 : AGT ( =1,301; =0,015); ( =1,251; =0,020)., ( =0,066; =0,025), ( =0,1; =0,002) ( = 0,156; <0,001)., ( =0,562; <0,001) ( =0,144; =0,001). ( ). = 1/1 + z, z = 0, , , , , , ,1 7 22, ,8% ,4724 >0, ,»,,,. «,,,,»,»,»,»,,,,»,»,»,». (,,»,, ),.
17 15,,.,,., -,,, [1, 12, 13, 15]. 2.., 235 AGT (OR=2,12, 95% CI: 1,16 3,86), (OR=2,24, 95% CI: 1,60 3,13) (OR=2,07, 95% CI: 1,48 2,88) [2, 3, 10, 14]. 3., MTHFR, MT AGT DD ACE,, ID ACE G2/M [4, 11]. 4. AGT, II ACE, AA REN, [4, 5, 11, 16] ,8%, : AGT ( =1,301; =0,015), ( =1,251; =0,020), ( =0,066; =0,025), ( =0,1; =0,002) ( = 0,156; <0,001), ( =0,562; <0,001) ( =0,144; =0,001) [3].
18 16 1. :, :,,,,,,,,»,,,,», [1, 12, 15];, AGT,,»,, [3]. 2.,,, : ;, II, [4, 5, 11, 16]; [3].
19 17 1.,.. /..,.. // AGT /..,..,..,..,.. // /..,..,..,..,.. // ,.. /.. // I/D /..,..,..,..,..,.. // C /..,..,..,..,..,..,.. // : 90 :... /...., ,.. /..,..,.. // :.. /... ;....,..., : /..,.....,..,..,..,.. // - :..., /... [.];....,...,
20 18 9. /..,..,..,..,..,..,.. // :,, : I.,, /,,.. ;.:.. [.]., /..,..,..,..,..,.. // : VII..,, /...,...., MTHFR /..,..,..,..,..,..,.. // :..-..,, /.., ,.. [ ] /.. // 2012 : /... ;...,..., : sborniki_tezisov_apsm/sbornik_tezisov_apsm_2012.pdf. : ,.., [ ] /.. // 2012 : /... ;...,..., : : ,.. [ ] /.. //
21 : /... ;...,..., : sbornik_tezisov_apsm_2013.pdf. : ,.., [ ] /..,.. // : /... ;...,..., : sborniki_tezisov_apsm/sbornik_tezisov_apsmif_2014.rar. : Association of the MTHFR C677T Polymorphism with leukocyte death in hypertensive men with abdominal obesity / O. Pavlyushchik, V. Afonin, V. Sarokina, T. Chak, A. Khapaliuk, M. Anisovich // 8th World congress on diabetes and obesity 2015: strategies, solutions and challenges, Riga, 2 3 July 2015 : progr. a. abstr. / Riga Stradins Univ. Riga, P. 35.
22 20 : ( ),,,,,. :,. :,,,. i i i. AGT,. MTHFR, MT AGT DD ACE.. AGT, AA REN. :,,», «i», «i»,»,,,,»,,,,». : AGT,,,,,,,,. i i: i,. :,.
23 21 : ( ),,,,,. :,. :,,,.. AGT,. MTHFR, MT AGT DD ACE.. AGT, II ACE, AA REN. :,,,,,,,,»,,,,»,. : AGT,,,,,,,,. :,. :,.
24 22 RESUME Sarokina Viktoryia Multifactorial Assessment of Risk of Developing Arterial Hypertension in Men Keywords: arterial hypertension, genetic predisposition, RAS system genes, apoptosis, micronuclei, personal features. Aim of research: to identify the most important risk criteria of development of arterial hypertension in men on the basis of comprehensive analysis of psychological, cell-biological and genetic characteristics. Methods of research: clinical, laboratory, instrumental, statistic. Results of research and their novelty. It was shown the association of MT genotype of the AGT gene with the risk of hypertension, with the presence of hypertensive crisis and hypertensive retinal angiopathy. The presence of heterozygous CT genotypes of the MTHFR gene, MT of the AGT gene and DD of the ACE gene in patients with hypertension reduced the proliferative cell activity of leukocytes. There were found out an increase in indicators of apoptosis of leukocytes and accumulation of cells with micronuclei in patients with hypertension. The association of TT genotype of AGT gene, II genotype of ACE gene, AA genotype of REN gene with activity of apoptosis and number of cells containing micronuclei. The personality traits such as «sociability», «emotional tension», «conservativeness», «depressiveness», «emotional lability», «misunderstanding», «self-esteem», «impulsivity», «negligence», «carelessness», «lack of persistence», «reverie», «artistry», «insensibility» were specific for patients with hypertension. The predicting risk formula of hypertension formation was calculated using such parameters as the presence of MT genotype of the AGT gene, hereditary predisposition to hypertension on the maternal side, body mass index, age. The calculated risk value as well as the presence of personality traits «extraversion», «emotional» and «separation» could be recommended for monitoring, clinical examination, early detection of hypertension. Recommendations for use: the obtained results are recommended for the assessment of individual risk of development of arterial hypertension in men in medical practice. They could be used also in the work of military medical commissions and in medical universities with educational purposes. Field of application: cardiology, therapy.
25 /16... «Times».... 1, , :».,, 1/ , 6, ,.
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