Development of a Branched LSA Endograft & Ascending Aorta Endograft
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1 Development of a Branched LSA Endograft & Ascending Aorta Endograft Frank R. Arko III, MD Sanger Heart & Vascular Institute Carolinas Medical Center Charlotte, North Carolina, USA
2 Disclosures
3 Proximal Landing Zone in TEVAR is Crucial Up to 40% of patients undergoing TEVAR have planned coverage of LSA to achieve an adequate proximal seal Surgeons revascularize the LSA either: Routinely Selectively Not unless symptomatic JEVT 2007;14:568-73
4 Potential Consequences of LSA Coverage without Revascularization Upper limb ischemia Subclavian steal syndrome Type II endoleak Spinal cord ischemia Stroke (ant. & post. circulation) Coverage of LSA without revascularization is the single most important predictor of post-tevar stroke 1 (OR, 3.8; 95% CI, ; p<0.001) 1 J Vasc Surg 2014;60:1491-8
5 SVS Guideline Recommendations on Management of LSA Based on systematic review of the literature, SVS recommends: Routine revascularization In elective cases In those with compromised perfusion to critical organs Selective revascularization After urgent scenarios J Vasc Surg 2009;50:1155-8
6 Endovascular Revascularization of LSA Valiant Mona LSA Modified Valiant Captivia Flexible LSA Cuff Dedicated Branch Stent Graft Dual Wire System Pre-cannulated LSA Cuff Snaring of LSA wire CAUTION: Investigational device, limited by law (US) to investigational use only.
7 Emergency and Compassionate Use Cases Sanger Heart and Vascular Institute Carolinas Medical Center
8 Emergency Use Case 84 y/o female with transverse arch aneurysm Conservatively managed for 2 years post-diagnosis Presented symptomatic with worsening upper back/scapula pain CTA indicated rapidly expanding TAA with asymmetric expansion of anterior wall Bovine arch with patent LSA Marginal access vessels ( mm)
9 Initial CTA
10 3D Reconstruction
11 Proximal Target Landing Zone Diameter 40mm Length 13.5mm
12 Addressing Access A right-sided retroperitoneal exposure was performed in standard fashion A 10x30 Dacron was sewn onto the right mid-common iliac to ensure safe delivery and removal of the delivery system (25F)
13 Graft Orientation Snaring and Positioning Angiogram
14 Deployment of 46 x 46 x 150 Valiant Mona LSA
15 Placement of LSA Branch Positioning of 10x40 LSA Branch Graft Ballooning of 10x40 LSA Branch Graft
16 Final Angiogram
17 Compassionate Use Case 61 y/o female with traumatic pseudoaneurysm at base of Innominate post-mva Poly-trauma: Small left pneumothorax Multiple cervical fractures Bilateral subdural hematoma Subarachnoid hemorrhage C5/C6 cord injury resulting in bilateral lower extremity paralysis Device Plan: 30x30x150 MSG with 14mm BSG
18 Initial CTA & 3D Rendering
19 Initial Angiogram
20 Positioning/Snaring of Wires for Graft Orientation
21 Confirmation of Alignment
22 Final Angiogram
23 Current Status with Valiant Mona LSA Feasibility Study 7 sites in the USA and 24 additional patients 15 patients currently enrolled Indication expansion received Chronic Type B Aortic Dissection 20 additional patients 3 additional sites CAUTION: Investigational device, limited by law (US) to investigational use only.
24 Development of an Ascending Aorta Endograft
25 Ascending Aortic TEVAR PSIDE Feasibility Study Evaluate Valiant thoracic endografts for treatment of ascending thoracic lesions with preserved tubular aortic anatomy (non-aneurysmal) deployment accuracy stability of device in ascending aorta assess aortic remodeling *CAUTION-Investigational device. Limited by Federal (or United States) law to investigational use.
26 Valiant Ascending is a modified Valiant Thoracic Stent Graft with Captivia Delivery System Freeflo Closed Web *CAUTION-Investigational device. Limited by Federal (or United States) law to investigational use.
27 Valiant Ascending PS-IDE Indications Type A Aortic Dissection Retrograde Type A Aortic Dissection Intramural hematoma, Penetrating Athero Ulcer Pseudoaneurysm between Sinus of Valsalva and Innominate orifice (with no involvement of the aortic valve) Proximal and Distal Landing Zones between mm diameter Non-surgical or Very High-Risk Surgical Candidate *CAUTION-Investigational device. Limited by Federal (or United States) law to investigational use.
28 Valiant Ascending PS-IDE Contra-Indications Type A Dissection with Aortic Valve/Root Involvement Diffuse Ascending Aneurysm Annulo-Aortic Ectasia Pregnant or Pediatric Patients Infections, Allergies, No Consent Expected Survival Less Than 1 Year *CAUTION-Investigational device. Limited by Federal (or United States) law to investigational use.
29 TEVAR for Ascending Aorta: Technical Considerations Hemodynamics, aortic regurg, coronary anatomy including CABG Access evaluation, transapical? Radial/brachial/carotid access Transfemoral RV pacing TEE, IVUS, Angio, CTA Bailout maneuvers HLM in standby Parallax and deployment accuracy *CAUTION-Investigational device. Limited by Federal (or United States) law to investigational use.
30 Valiant Ascending: Case Example *CAUTION-Investigational device. Limited by Federal (or United States) law to investigational use.
31 Valiant Ascending: Case Example *CAUTION-Investigational device. Limited by Federal (or United States) law to investigational use.
32 Valiant Ascending PS-IDE Current Experience 10 Patients Consented for PS-IDE Study Early Results No Early Mortality or Early Open Conversion 100% Technical Success (Delivery and Deployment) 1/9 stroke, 1/9 Type Ia Endoleak (same patient) Open repair (FET procedure) at 2 mo, death at 4 mo *CAUTION-Investigational device. Limited by Federal (or United States) law to investigational use.
33 Ascending TEVAR Lessons Learned Valiant Ascending provides durable treatment of lesions of the thoracic aorta with tubular aortic anatomy (non-aneurysmal) No deployment or device stability issues Aortic remodeling of lesions similar to descending thoracic devices *CAUTION-Investigational device. Limited by Federal (or United States) law to investigational use.
34 Conclusions Preliminary evaluation of Valiant Ascending endografts demonstrates: Accurate deployment Secure fixation No migration Longer-term follow-up required to demonstrate durable exclusion *CAUTION-Investigational device. Limited by Federal (or United States) law to investigational use.
35 Development of a Branched LSA Endograft & Ascending Aorta Endograft Thank You Frank R. Arko III, MD Sanger Heart & Vascular Institute Carolinas Medical Center Charlotte, North Carolina, USA
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