Chien-Hua Chen MD, MPH. Show-Chwan Memorial Hospital, Taiwan Taiwan. Position: Dean of Community Health Promotion Center

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1 Chien-Hua Chen MD, MPH Show-Chwan Memorial Hospital, Taiwan Taiwan Position: Dean of Community Health Promotion Center Major Field:Digestive US, EUS, Digestive endoscopy Education: MD, China Medical University / MPH, Tulane University Professional Experience: Superintendent of Show-Chwan Memorial Hospital, Taiwan Publications: 1. Chen, C. H., Yang, C. C., & Yeh, Y. H. For Biliary Dilatation, a Negative Endosonography Needs Additional Image Studies in Weight Loss Suggesting Malignancy. Digestive diseases and sciences, 2013; 58: Chen CH, Yang SL, Yeh YH, et al. Yang SL, Chen CH, Yeh YH, Yueh SK. Endoscopic removal of an embedded partially covered esophageal self-expandable metallic stent by overtube technique. Endoscopy 2011; 43 Suppl 2 UCTN: E Chen CH, Nien CK, Yang CC, et al. Association between nonalcoholic fatty liver disease and coronary artery calcification. Dig Dis Sci 2010; 55: Yan SL, Wu ST, Chen CH, et al. Mucosal patterns of helicobacter pylori-related gastritis without atrophy in the gastric corpus using standard endoscpy. World J Gastroenterol 2010 Jan 28; 16(4): Chen CH, Yang CC, Yeh YH, et al. Reappraisal of endosonography of ampullary tumors: correlation with transabdominal sonography, CT and MRI. J Clin Ultrasound Jan; 37(1): Yang SL, Chen CH, Yeh YH. Successful biliary stenting and sphincterotomy using an ultrathin forward-viewing endoscope. Endoscopy 2009 Mar; 41 Suppl 2:E59-60.

2 6. Chen CH, Lin ST, Kuo, CL., et al. Clinical significance of elevated alpha-fetoprotein (AFP) in chronic hepatitis C without hepatocellular carcinoma. Hepatogastroenterology Jul-Aug; 55(85): Chen CH, Lin ST, Yang CC, et al. The Accuracy of Sonography in Predicting Steatosis and Fibrosis in Chronic Hepatitis C. Dig Dis Sci Jun; 53(6): Chu YC, Yang CC, Yeh YH, Chen CH, et al. Double-balloon enteroscopy application in biliary tract disease-its therapeutic and diagnostic functions. Gastrointest Endosc 2008; 68: Chen CH, Huang MH, Yang JC, et al. The treatment of isolated left-sided hepatolithiasis. Hepatogastroenterology Mar-Apr;55(82-83): Chu YC, Yeh YH, Yang CC, Chen CH, et al. A new indication for double-balloon enteroscopy: removal of migrated metal stents through a Roux-en-Y anastomosis. 11. Endoscopy Feb; 39 Suppl 1:E Yang CC, Chen CH, Yan SL. Endoscopic detection of colonic tuberculosis in an asymptomatic patient. Endoscopy Feb;39 Suppl 1:E Chu YC, Su SJ, Yang CC, Yeh YH, Chen CH, et al. ERCP plus papillotomy by use of double-balloon enteroscopy after Billroth II gastrectomy. Gastrointest Endosc Dec; 66(6): Chen CH, Huang MH, Yang JC, et al. Prevalence and etiology of elevated serum alanine aminotransferase level in an adult population in Taiwan. J Gastroenterol Hepatol Sep; 22(9): Yan SL, Yeh YH, Chen CH, et al. Gastric glomus tumor: a hypervascular submucosal tumor on power Doppler endosonography. J Clin Ultrasound Mar-Apr;35(3): Chen CH, Huang MH, Yang JC, et al. Prevalence and risk factors of gallstone disease in an adult population of Taiwan: an epidemiological survey. J Gastroenterol Hepatol Nov; 21(11): Chen CH, Huang MH, Yang JC, et al. Prevalence and risk factors of nonalcoholic fatty liver disease in an adult population of Taiwan: metabolic significance of nonalcoholic fatty liver disease in nonobese adults. J Clin Gastroenterol Sep; 40(8): Chen C, Huang M, Yang J, et al. Reappraisal of percutaneous transhepatic cholangioscopic lithotomy for primary hepatolithiasis. Surg Endosc Apr;19(4): Huang MH, Chen CH, Yen CM, et al. Relation of hepatolithiasis to helminthic infestation. J Gastroenterol Hepatol Jan; 20(1): (Corresponding author) 20. Chen CH, Yang CC, Yeh YH, et al. Contrast-enhanced power Doppler sonography of ductal pancreatic adenocarcinomas: correlation with digital subtraction angiography findings. J Clin Ultrasound May; 32(4): Huang MH, Chen CH, Yang JC, et al. Long-term outcome of percutaneous transhepatic cholangioscopic lithotomy for hepatolithiasis. Am J Gastroenterol Dec; 98(12): (Corresponding author) 22. Chen CH, Yang CC, Yeh YH, et al. Gastric wall abscess presenting as a submucosal tumor:

3 case report.. Gastrointest Endosc Jun; 57(7): Yang CC, Chen CH, Yeh YH. Enhanced color flows in hepatic tumors. Hepatogastroenterology Nov-Dec;49(48): (Corresponding author) 24. Chen CH, yang CC, Yeh YH. Preoperative staging of gastric cancer by endoscopic ultrasound: the prognostic usefulness of ascites detected by endoscopic ultrasound. J Clin Gastroenterol Oct; 35(4): Chen CH, Tseng LJ, Yang CC, et al. The accuracy of endoscopic ultrasound, endoscopic retrograde cholangiopancreatography, computed tomography, and transabdominal ultrasound in the detection and staging of primary ampullary tumors. Hepatogastroenterology Nov-Dec; 48(42): Chen CH, Yang CC, Yeh YH, et al. Duodenal plasmacytoma. Gastrointest Endosc Dec;54(6): Chen CH, Huang HS, Yang CC, et al. The features of perforated peptic ulcers in conventional computed tomography. Hepatogastroenterology Sep-Oct;48(41): Chen CH, yang CC, Yeh YH. Role of upright chest radiography and ultrasonography in demonstrating free air of perforated peptic ulcers. Hepatogastroenterology Jul-Aug;48(40): Chen CH, Tseng LJ, Yang CC, et al. Preoperative evaluation of periampullary tumors by endoscopic sonography, transabdominal sonography, and computed tomography. J Clin Ultrasound Jul-Aug; 29(6): Chen CH, Yang CC, Yeh YH, et al. Ectopic pancreas located in the major duodenal papilla: case report and review. Gastrointest Endosc Jan;53(1): Chen CH, Yang CC, Yeh YH, et al. Pancreatic tuberculosis with obstructive jaundice--a case report. Am J Gastroenterol Sep; 94(9): Wei, C. Y., Chung, T. C., Chen, C. H., Lin, C. C., Sung, F. C., Chung, W. T.,... & Yeh, Y. H. (2014). Gallstone disease and the risk of stroke: a nationwide population-based study. Journal of Stroke and Cerebrovascular Diseases, 23(7), Wen, C. P., Zhang, F., Liang, D., Wen, C., Gu, J., Skinner, H. D.,... & Huang, M. (2014). The ability of bilirubin in identifying smokers with higher risk of lung cancer: a large cohort study in conjunction with global metabolomic profiling. Clinical Cancer Research, clincanres Chen, C. H., Lin, C. L., & Kao, C. H. (2016). Irritable bowel syndrome is associated with an increased risk of dementia: a nationwide population-based study. PloS one, 11(1), e Lee, J. H., Yan, S. L., Chen, C. H., Yeh, Y. H., & Yueh, S. K. (2014). Endoscopic retrieval of a proximally migrated biliary plastic stent using a guidewire loop technique. Endoscopy, 46(S 01), E232-E Yan, S. L., Chen, S. F., Chen, C. H., & Yeh, Y. H. (2015). Pyogenic granuloma of the transverse colon. Gastrointestinal endoscopy, 82(4), Yan, S. L., Chang, C. S., Chen, C. H., Yeh, Y. H., & Tsai, C. Y. (2016). Reticulocyte

4 production index as a predictor of clinically significant anemia in chronic hepatitis C patients receiving pegylated interferon combination therapy. Advances in Digestive Medicine, 3(1), Chen, C. H., Yang, C. C., Yeh, Y. H., Yang, T., & Chung, T. C. (2015). Endosonography for suspected obstructive jaundice with no definite pathology on ultrasonography. Journal of the Formosan Medical Association, 114(9), Chen, C. H., Lin, C. L., & Kao, C. H. (2015). Association of gallbladder polyp and stroke: a nationwide, population-based study. Medicine, 94(48), e Chen, C. H., Tsai, M. K., & Wen, C. P. (2016). Extending colorectal cancer screening to persons aged 40 to 49 years with immunochemical fecal occult blood test: a prospective cohort study of 513,283 individuals. Journal of clinical gastroenterology, 50(9), Yang, T. H., Yan, S. L., Chen, C. H., Yeh, Y. H., & Yueh, S. K. (2014). Redeployment of proximally misplaced self-expandable metallic stent in an inoperable esophageal carcinoma, using an overtube technique. Endoscopy, 46(S 01), E260-E Yan, S. L., Lee, Y. T., Chen, C. H., Yeh, Y. H., & Yueh, S. K. (2014). Pericarditis: a rare complication of fully covered self-expandable metallic stent in postoperative benign anastomotic stricture. Endoscopy, 46(S 01), E453-E Chen, C. H., Yan, S. L., Yang, T. H., Chen, S. F., Yeh, Y. H., Ou, J. J.,... & Chen, C. H. (2016). The Relationship between the Methylated Septin 9 DNA Blood Test and Stool Occult Blood Test for Diagnosing Colorectal Cancer in Taiwanese People. Journal of clinical laboratory analysis. 44. Chen, C. H., Hsu, C. M., Lin, C. L., Chou, A. K., & Jeng, L. B. (2016). The Development of Diabetes after Subtotal Gastrectomy with Billroth II Anastomosis for Peptic Ulcer Disease. PloS one, 11(11), e Wen, C. P., Chang, C. H., Tsai, M. K., Lee, J. H., Lu, P. J., Tsai, S. P.,... & Wu, X. (2017). Diabetes with early kidney involvement may shorten life expectancy by 16 years. Kidney International. 46. Chen, C. H., Lin, C. L., Cheng, Y. S., & Jeng, L. B. (2017). Association Between Subtotal Gastrectomy with Billroth II Anastomosis and Coronary Heart Disease. Obesity Surgery, Chen, C. H., Lin, C. L., & Kao, C. H. (2016). Gastroesophageal reflux disease with proton pump inhibitor use is associated with an increased risk of osteoporosis: a nationwide population-based analysis. Osteoporosis International, 27(6), Wu, X., Tsai, S. P., Tsao, C. K., Chiu, M. L., Tsai, M. K., Lu, P. J.,... & Hsu, C. Y. (2017). Cohort Profile: The Taiwan MJ Cohort: half a million Chinese with repeated health surveillance data. International Journal of Epidemiology. 49. Chen, C. H., Lin, C. L., & Kao, C. H. (2016). Subtotal Gastrectomy With Billroth II Anastomosis Is Associated With a Low Risk of Ischemic Stroke in Peptic Ulcer Disease Patients: A Nationwide Population-Based Study. Medicine, 95(16). 50. Chen, C. H., Lin, C. L., & Kao, C. H. (2015). Association between chronic hepatitis B virus infection and risk of osteoporosis: a nationwide population-based study. Medicine, 94(50).

5 51. Chen, C. H., Lin, C. L., & Kao, C. H. (2015). Relation Between Hepatitis C Virus Exposure and Risk of Osteoporosis: A Nationwide Population-Based Study. Medicine, 94(47), e2086-e Chen, C. H., Wen, C. P., & Tsai, M. K. (2016). Fecal immunochemical test for colorectal cancer from a prospective cohort with 513,283 individuals: Providing detailed number needed to scope (NNS) before colonoscopy. Medicine, 95(36). 53. Chen, C. H., Lin, C. L., & Kao, C. H. (2016). Association between gallbladder stone disease and prostate cancer: A nationwide population-based study. Oncotarget, 7(39),