The Changing Landscape of Managing Patients with PAD- Update on the Evidence and Practice of Care in Patients with Peripheral Artery Disease
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1 Interventional Cardiology and Cath Labs The Changing Landscape of Managing Patients with PAD- Update on the Evidence and Practice of Care in Patients with Peripheral Artery Disease Manesh R. Patel MD Chief, Division of Cardiology Co-Director Duke Heart Center Duke University All Rights Reserved, Duke Medicine 2008
2 Disclosures Member of Appropriate Use Criteria Task Force: Current AUC Chair Research Support: AstraZeneca, CSI, HeartFlow, Janssen Research & Development, Johnson & Johnson, Bayer, Medtronic, National Heart, Lung, & Blood Institute Consulting/Advisory Board: AstraZeneca, CSI, Bayer Corporation, Janssen Research & Development,Merck & Co.
3 PAD is Common NHANES 1 Aged >40 years San Diego 2 Mean age 66 years NHANES 1 Aged 70 years Rotterdam 3 Aged >55 years Diehm 4 Aged 65 years 4.3% 11.7% 14.5% PARTNERS 5 Aged >70 years, or years with a history diabetes or smoking 19.1% 19.8% In a primary care population defined by age and common risk factors, the prevalence of new and established PAD was approximately one in three patients 29% 0% 5% 10% 15% 20% 25% 30% 35% NHANES=National Health and Nutrition Examination Study; PARTNERS=PAD Awareness, Risk, and Treatment: New Resources for Survival [program]. 1. Selvin E, Erlinger TP. Circulation. 2004;110: Criqui MH, et al. Circulation. 1985;71: Diehm C, et al. Atherosclerosis. 2004;172: Meijer WT, et al. Arterioscler Thromb Vasc Biol. 1998;18: Hirsch AT, et al. JAMA. 2001;286:
4 All Rights Reserved, Duke Medicine 2007 Prevalence of PAD is rising -- estimated 202 million people in 2010
5 All Rights Reserved, Duke Medicine 2007 Diagnosis of PAD
6 Noninvasive Diagnosis Interpretation of ABI >1.30 Noncompressible Normal Mild/moderate PAD 0.40 Severe PAD/critical limb ischemia Jan08MP
7 All Rights Reserved, Duke Medicine 2007 Natural History and Outcomes
8 High ABI portends risk Life-line screening (3.6 million ABI measurements) All Rights Reserved, Duke Medicine 2007
9 All Rights Reserved, Duke Medicine 2008 After age, CRI is strongest predictor
10 One year MACE rates remain high post amputation with PAD 10 All Rights Reserved, Duke Medicine 2008
11 Up to 30% of patients do not get arterial testing prior to amputation in US 11 All Rights Reserved, Duke Medicine 2008
12 2 Major Issues in Peripheral Arterial Disease PAD Management Symptom Improvement* Cardiovascular Risk Reduction* *In symptomatic patients only (atypical or classical?) All Rights Reserved, Duke Medicine 2007
13 Consequences of PAD Amputation/Tissue Loss Myocardial infarction (MI) Stroke Death Functional capacity Quality of Life 13
14 Goals of Therapies for PAD All PAD patients Patients with IC Patients with CLI Improve functional status Prevent leg amputation Reduce cardiovascular morbidity & mortality Restore mobility Reduce morbidity & mortality Reduce mortality 14
15 Risk Factor Management / Prevention Stop smoking! Treat diabetes! Antiplatelet treatment / Anti-thrombotic Statins ACE inhibitors All Rights Reserved, Duke Medicine 2007
16 Mechanism for CV protection Jones and Patel Review Submitted All Rights Reserved, Duke Medicine 2007
17 Cumulative Event Rate (%) Efficacy of Clopidogrel vs. Aspirin in MI, Ischemic Stroke, or Vascular Death 8.7%* 16 Overall Relative Risk Reduction ASA % % Clopidogrel Months of Follow-Up N=19,185 ASA=aspirin. Mean follow-up=1.91 years. *ITT analysis. Reprinted with permission from CAPRIE Steering Committee. Lancet. 1996;348:
18 Risk Reduction of Clopidogrel vs. Aspirin in Patients With Atherosclerotic Vascular Disease Aspirin favored Clopidogrel favored Stroke N=19,185 MI PAD All patients Effect in PAD patients drive results Reprinted with permission from CAPRIE Steering Committee. Lancet. 1996;348:
19 Clopidogrel Monotherapy is Mildly Superior to ASA In patients with prior atherosclerotic disease Clopidogrel is currently indicated for PAD patients All Rights Reserved, Duke Medicine 2007
20 Cumulative Event Rate* (%) CHARISMA: Affect of Clopidogrel Plus Aspirin vs. Aspirin Alone on MI, Stroke, or CV Death First occurrence of MI (fatal or nonfatal), stroke (fatal or nonfatal), or CV death Placebo + ASA 7.3% Clopidogrel + ASA 6.8% 2 RRR 7.1% (95% CI: -4.5%, 17.5%) P= Months Since Randomization ASA=aspirin; CI=confidence interval; MI=myocardial infarction; RRR=relative risk ratio. *All patients received ASA mg/day; The number of patients followed beyond 30 months decreases rapidly to zero; only 21 primary efficacy events occurred beyond this time (13 clopidogrel and 8 placebo). Bhatt DL, Fox KA, Hacke W, et al. N Engl J Med 2006;354:1706.
21 Overall Population: Safety Results Clopidogrel Placebo + ASA + ASA Safety Outcome* - N (%) (n=7802) (n=7801) RR (95% CI) p value GUSTO Severe Bleeding 130 (1.7) 104 (1.3) 1.25 (0.97, 1.61) 0.09 Fatal Bleeding 26 (0.3) 17 (0.2) 1.53 (0.83, 2.82) 0.17 Primary ICH 26 (0.3) 27 (0.3) 0.96 (0.56, 1.65) 0.89 GUSTO Moderate Bleeding 164 (2.1) 101 (1.3) 1.62 (1.27, 2.08)<0.001 *Adjudicated outcomes by intention to treat analysis ICH= Intracranial Hemorrhage Bhatt DL, Fox KA, Hacke W, et al. NEJM 2006.
22 Dual Anti-platelet Therapy with Clopidogrel / ASA not Better than Placebo / ASA Similar efficacy events in CHARISMA Increase in Moderate GUSTO bleeding with DAP All Rights Reserved, Duke Medicine 2007
23 Aspirin in PAD Meta Analysis Efficacy on Composite CV JAMA 2009;301: All Rights Reserved, Duke Medicine 2007
24 In PAD population, treatment with vorapaxar resulted in: Reduced rates of hospitalization for ALI Reduction in urgent vascular hospitalization Reduced rates of peripheral revascularization All Rights Reserved, Duke Medicine 2007
25 EUCLID Study Design Key exclusion criteria: Poor metabolizer for CYP2C19 Patients requiring dual anti-platelet therapy Patients with symptomatic PAD Ticagrelor 90 mg bid Double-blind Double-dummy 1:1 N=13,885 Clopidogrel 75 mg od Duration: Event Driven Trial Approximately 14-month recruitment and 26-month follow-up Inclusion criteria: Symptomatic PAD AND one of the following: A. ABI 0.80 at Visit at Visit 2 OR B. Prior lower extremity revascularization > 30 days Primary Endpoint: cardiovascular death, myocardial infarction, or ischemic stroke Primary Safety Endpoint: TIMI major bleeding
26 Medical History Ticagrelor (N=6930) Clopidogrel (N=6955) History of stroke, no. (%) 576 (8.3) 567 (8.2) History of TIA, no. (%) 279 (4.0) 228 (3.3) CAD, no. (%) 2019 (29.1) 2013 (28.9) MI, no. (%) 1242 (17.9) 1280 (18.4) Number of vascular beds, no. (%) (55.9) 3930 (56.5) (33.7) 2355 (33.9) (10.4) 670 (9.6) Diabetes mellitus (Type I & II), no. (%) 2639 (38.1) 2706 (38.9) Hypertension, no. (%) 5437 (78.5) 5420 (77.9) Hyperlipidemia, no. (%) 5229 (75.5) 5251 (75.5) CAD is defined as prior MI, prior PCI, or prior CABG. A vascular bed is defined as either PAD, prior CAD (prior MI, prior PCI, or prior CABG), or prior cerebrovascular disease (prior stroke, prior TIA, prior carotid artery stenosis or prior carotid revascularization). ABI indicates ankle-brachial index; ACE, angiotensin converting enzyme; ARB, angiotensin receptor blocker; CAD, coronary artery disease; MI, myocardial infarction, PAD, peripheral artery disease; SD, standard deviation; TBI, toe-brachial index; TIA, transient ischemic attack.
27 Primary Efficacy Endpoint (CV Death, MI, or Ischemic Stroke)
28 Efficacy Outcomes Ticagrelor (N=6930) Clopidogrel (N=6955) HR (95% CI) P Value Primary outcome: Composite of CV death, MI, or ischemic stroke, no. (%) 751 (10.8) 740 (10.6) CV death, no. (%) 363 (5.2) 343 (4.9) MI, no. (%) 349 (5.0) 334 (4.8) Ischemic stroke, no. (%) 131 (1.9) 169 (2.4) Key secondary efficacy outcome: Composite of CV death, MI, ischemic stroke, or ALI requiring hospitalization, no. (%) 839 (12.1) 833 (12.0) 1.02 ( ) 1.07 ( ) 1.06 ( ) 0.78 ( ) 1.02 ( ) ALI indicates acute limb ischemia; CI, confidence interval; CV, cardiovascular; HR, hazard ratio; MI, myocardial infarction.
29 All Rights Reserved, Duke Medicine 2007
30 All Rights Reserved, Duke Medicine 2007
31 All Rights Reserved, Duke Medicine 2007
32 All Rights Reserved, Duke Medicine 2007
33 All Rights Reserved, Duke Medicine 2007
34 Anti-platelet therapy conclusions - PAD: PAD is common, and patients with PAD have high risk for cardiovascular events Clopidogrel is equivalent to ASA in prevention of CV events in patients with broadly defined vascular disease but nominally superior in PAD In patients with broadly defined vascular disease, dual anti-platelet therapy provided no clinical benefit Vorapaxar on top or ASA or Clopidogrel benefit in PAD patients Ticagrelor was similar to clopidogrel for PAD clinical event reduction All Rights Reserved, Duke Medicine 2007
35 PAD Patients Dual Pathway therapy (oral anticoagulant at the right dose) with low dose ASA (anti-platelet) therapy seems to provide clinical benefit Test strategy in PVI patients (VOYAGER PAD) Test understanding individual CV risks in patients with PAD All Rights Reserved, Duke Medicine 2007
36 All Rights Reserved, Duke Medicine 2007 Questions
37 Wide variation and potentially significant underuse of anti-thrombotic therapy Subherwal, Patel, Jones, et al, Circulation 2012 All Rights Reserved, Duke Medicine 2007
38 All Rights Reserved, Duke Medicine 2007 Where is PAD care and research going?
39 MACE + ischaemic limb risk Compared with COMPASS, VOYAGER PAD targets a patient population at high risk of cardiovascular events Early risk Late risk VOYAGER 1 EUCLID 3 ATLAS ACS 2 COMPASS 4 Acute event (ACS, limb revascularization) Time Chronic disease (stable PAD, CV disease) Mega JL et al, N Engl J Med 2012;366:9 19; 3. Hiatt WR et al, N Engl J Med 2017;376:32 40; 4. Eikelboom JW et al. N Engl J Med 2017; DOI: /NEJMoa
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