International. CytoSorb. Users Meeting. October 2 nd 2015 Pullman Hotel Schweizer Hof Berlin, Germany

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1 2 nd International CytoSorb Users Meeting October 2 nd 2015 Pullman Hotel Schweizer Hof Berlin, Germany

2 2nd International CytoSorb Users Meeting Dear CytoSorb user, Just before the start of the 28th Annual Congress of the ESICM we would like to update you on news and developments of the CytoSorb Therapy: you will learn about latest scientific findings on the application of CytoSorb in Septic Shock, Cardiac Surgery, Liver Disease, and many other fields. An update on the International CytoSorb Registry will be presented as well as several case series and the status of the different clinical trials from all over the world. We will let the event gently fade away with a delicious dinner and some jazzy grooves... We are looking forward to meeting you in Berlin! Your CytoSorbents Europe Team

3 Program am Registration and lunch buffet pm Opening Christian Steiner, CytoSorbents Europe pm Keynote lectures Chair: Frank Brunkhorst, Jena, Germany pm The immune system and its inflammatory response types Herwig Gerlach, Berlin, Germany 1.00 pm The impact of Cytosorb on the immune response John Kellum, Pittsburgh, USA 1.20 pm Clinical Data 1 Chair: Dana Tomescu, Bucharest, Romania & Yeon-Hoon Choi, Cologne, Germany 1.20 pm Early application of CytoSorb in septic shock - A 10vs10 pilot study Zsolt Molnar, Szeged, Hungary

4 1.35 pm CytoSorb in cardiac surgery with cardiopulmonary bypass (CPB) - A 300 patient three-arm-study Antje-Christin Deppe, Cologne, Germany 1.50 pm CytoSorb for modulation of SIRS during cardiac surgery with CPB - A 20vs20 pilot study Jens Kubitz, Hamburg, Germany 2.05 pm Coffee break 2.25 pm CytoSorb cases and case series pm CytoSorb in a young patient with toxic shock syndrome Erwin van der Linde, Rotterdam, The Netherlands 2.35 pm Effect of CytoSorb in a patient with sepsis and liver dysfunction Dana Tomescu, Bucharest, Romania 2.45 pm CytoSorb treatment in a child with necrotizing fasciitis Georgi Arabadzhiev, Stara Zagora, Bulgaria 2.55 pm CytoSorb use in a case of liver failure Christian Siebers, Munich, Germany 3.05 pm Clinical experience in patients with burns Gerald Ihra, Vienna, Austria 3.20 pm CytoSorb experiences in H1N1 patients Abdul Ansari, Leelavathi, India 3.35 pm Case series of CytoSorb treatments in patients with severe sepsis Tommaso Laddomada, Zingonia, Italy

5 Program 3.50 pm Discussions 4.00 pm Clinical Data 2 Chairs: Marco Maggiorini, Zurich, Switzerland & Detlef Kindgen-Milles, Duesseldorf, Germany 4.00 pm Effect of cytokine adsorption during CPB in cardiac surgery - A 20vs20 pilot study Martin Bernardi, Vienna, Austria 4.15 pm Levels of immunosuppressive drugs during CytoSorb treatment Steffen Mitzner, Rostock, Germany 4.30 pm The International CytoSorb Registry - Current status Frank Brunkhorst, Jena, Germany 4.45 pm Coffee break

6 5.10 pm CytoSorb cases and case series pm Case series in post-operative cardiac surgery patients Karl Träger, Ulm, Germany 5.25 pm CytoSorb treatments with citrate anticoagulation Detlef Kindgen-Milles, Duesseldorf, Germany 5.40 pm Use of CytoSorb in patients with myoglobinemia Claus Krenn, Vienna, Austria 5.55 pm A case series of CytoSorb in septic patients Reshma Tewari, Gurgaon, India 6.10 pm Discussion, Q&A Moderator: Zsolt Molnar, Szeged, Hungary 6.50 pm Closing remarks Phil Chan, CEO CytoSorbents Corporation 7.00 pm The End 8.00 pm Dinner and Come together

7 Poster award Please send your poster with a particular case report, case series, study or experimental work on your CytoSorb application until September 22 nd 2015 to support@cytosorbents.com The posters are endowed as follows : 1 st Prize nd Prize rd Prize 250 Please provide your poster in format A0 (84cm x 119cm) in English language submit your POSTER and WIN Registration & information Please register until September 15 th 2015 with our office in Berlin or under You are welcome to contact us for any further information you might require. CytoSorbents Europe GmbH Bölschestraße 116, Berlin, Germany phone: support@cytosorbents.com

8 Venue & Date Pullman Hotel Schweizerhof Berlin Budapester Straße Berlin Germany October 2nd, am - open end An easy stroll from the Pullman Berlin Schweizerhof leads to the shops along Kurfürstendamm or to the KaDeWe department store. You can also visit the Berlin Zoo just opposite. VENUE & REGISTRATION

9 Notes

10 CytoSorbents Europe GmbH Bölschestraße Berlin Germany Phone Fax support@cytosorbents.com CytoSorb and CytoSorbents are trade marks of the CytoSorbents Corporation, USA. B1024R01EN2015 Copyright 2015, CytoSorbents Europe GmbH. All rights reserved.

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