Mitral Regurgitation:

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1 Mitral Regurgitation: Diagnosis and Treatment 2018 Annual Chattanooga Cardiology Symposium 10 February, 2018 Allen E. Atchley, MD

2 Disclosures None Objectives: 1. Understand functional vs. degenerative MR 2. Understand MR severity grading 3. Understand indications for surgery/intervention

3 Outline Epidemiology/Anatomy Regurgitation Classification Myxomatous Degeneration MR Severity Grading Guidelines for Management MitraClip Procedural Animation Case Presentation

4 Epidemiology Mitral regurgitation prevalence (any) 70% by TTE Significant (Moderate-Severe) 2-3% of general population 7-8 million U.S. adults million world wide

5 atomy/leaflets.jpg Online access 10/2017. Mitral valve anatomy

6 Pathophysiology Chronic MR = Volume Insidious: Structural s PRECEDE symptoms Symptoms: Heart Failure - Exertional SOB - Activity Intolerance - Fatigue - Edema - Orthopnea - Cough Palpitations (Atrial Fibrillation)

7 MR Etiology Degenerative MR - Primary/Organic - Structural abnormality of any part of the mitral apparatus Functional MR - Secondary MR - LV dysfunction/enlargement

8 MR Etiology

9 Carpentier Classification 58/ Access online 10/2017

10 Myxomatous Schematic of normal Degeneration: mitral valve histology. Fibroelastic Deficiency (FED) VEC: Valvular Endothelial Cells VIC: Valvular Interstitial Cells Francesca N. Delling, and Ramachandran S. Vasan Circulation. 2014;129: Copyright American Heart Association, Inc. All rights reserved.

11 Myxomatous Degeneration: Spectrum of Disease _ehq22201&req=4. Access online 10/2017.

12 Myxomatous Degeneration: Progression of Disease Proposed temporal spectrum of mitral valve (MV) prolapse (MVP) progression with potential interventions/nonsurgical therapies depending on progression stage (bottom). Francesca N. Delling, and Ramachandran S. Vasan Circulation. 2014;129:

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14 MR Severity- Echo

15 MR Severity- Echo

16 Follow-up: ASE Guidelines Mild MR - Echo: q3-5 years Moderate MR - Echo: annual Severe MR - Referral (TEE +/- intervention) * Echo for any murmur or symptoms

17 Treatment Medical therapy - BP mgmt. (ARB/ACE-I) * MR is dynamic - diuretics CAD/Ischemia (IIIB) - revascularization?

18 Treatment: ARB? Animal study with ARB = protective antifibrotic/anti-inflammatory effect. EMT- endothelial to mesenchymal transition.

19 Clinical Outcomes: Med Rx From: Prevalence and Outcomes of Unoperated Patients With Severe Symptomatic Mitral Regurgitation and Heart Failure: Comprehensive Analysis to Determine the Potential Role of MitraClip for This Unmet Need 1095 patients with Severe MR and HF FMR 74%, DMR 21%, Other 5% 53% Medical Therapy and 47% Surgery Journal of the American College of Cardiology Jan 2014, 63 (2) ; DOI: /j.jacc

20 Treatment Surgical - Valve replacement - Mechanical (warfarin) - Bioprosthetic (90%, warfarin 3-6mo. then ASA) - Valve repair - Ring +/- resection - Alfieri stitch * DMR- prohibitive surgical risk - Transcatheter repair (MitraClip)

21 ACC Guidelines: Surgery LV Dysfxn: EF < 60% ESd > 4cm EF < 30% or ESd > 5.5 cm = Med Rx IIb- Left Atrial Enlargement

22 109 Pts with Asymptomatic MR: Quantified by cmri

23 Early Surgery: Asymptomatic Severe MR Duk-Hyun Kang et al. Circulation. 2009;119:

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25 Case Case 85 y/o with progressive HF symptoms (exertional shortness of breath and fatigue) 3-4/6 murmur of MR on exam

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41 Conculsions Degenerative MR- primary valve disease Functional MR- secondary (LV dysfxn, MI, etc.) Chronic MR is insidious - structural s typically precede HF signs/symptoms Medical Therapy- limited role in treatment Early Surgical Intervention! - severe MR +/- LVEF < 60% or LVSd > 4.0cm High risk patients with DMR-? MitraClip

42 References Nishimura RA, Otto CM, Bonow RO, Carabello BA, et al AHA/ACC Guideline for the Management of Patients with Valvular Heart Disease, Journal of the American College of Cardiology (2014, doi; /j.jacc ) Francesca N. Delling, and Ramachandran S. Vasan. Circulation. 2014; 129: Goel SS, Navkaranbir B, Aggarwal B, et al. Prevalence and Outcomes of Unoperated Patients With Severe Symptomatic Mitral Regurgitation and Heart Failure. JACC. 2014; 63 (2): Thavendiranathan P, Phelan D, Collier P, et al. Quantitative Assessment of Mitral Regurgitation. JACC Cardiovascular Imaging. 2012; 5 (11): Myerson SG, d Arcy J, Christiansen JP, et al. Determination of Clinical Outcome in Mitral Regurgitation With Cardiovascular Magnetic Resonance Quantification. Circulation. 2016;133:

43 Questions?

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