PLACE YOUR TRUST. in Boston Scientific Metal Stents IN THOUSANDS OF PHYSICIANS LIKE YOU IN PIONEERING DESIGNS IN CLINICAL EVIDENCE IN EXPERIENCE

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1 PLACE YOUR TRUST in Boston Scientific Metal Stents IN CLINICAL EVIDENCE IN PIONEERING DESIGNS IN THOUSANDS OF PHYSICIANS LIKE YOU IN EXPERIENCE

2 PROCEDURAL EXCELLENCE SUPPORTED BY CLINICAL EVIDENCE. Boston Scientific (BSC) is committed to supporting global clinical research that addresses clinically relevant questions and has the potential to change treatment algorithms and improve patient care Duodenal Stent in palliation of malignant gastric outlet obstruction Colonic Stent in palliation and bridge to surgery of malignant colonic strictures Fully Covered Biliary Stent in palliation of malignant biliary strictures Biliary Fully Covered Stent in treatment of benign biliary strictures Biliary Fully Covered Stent vs. multiple plastic stents in treatment of benign biliary strictures caused by chronic pancreatitis Biliary Stent in preoperative drainage of malignant biliary strictures

3 18 WALLSTENT Biliary First Boston Scientific biliary stent placed 11 Ultraflex Esophageal First Ultraflex esophageal stent placed FOR OVER 20 YEARS, Boston Scientific has been a leading developer of advanced stent technologies and remains committed to high quality standards and collaboration with physicians. 14 Ultraflex Esophageal First proximal and distal released stent 14 WALLSTENT Esophageal First Permalume covered stent Boston Scientific stent technology is built on science and innovation to expand options available for patient treatment and management.

4 18 WALLSTENT Colonic and Duodenal First colonic/duodenal stent indication in the U.S. WHAT PHYSICIANS ARE SAYING 2000 WALLSTENT Biliary Endoprosthesis First covered biliary stent 2001 WALLSTENT Biliary RX First RX biliary stent 200 WallFlex Colonic and Duodenal First WallFlex Enteral Stent placed Boston Scientific is seeking to deliver the best possible care to patients by promoting and conducting important clinical studies while constantly evaluating and improving upon their products. This not only advances our scientific knowledge but also contributes to facilitate evidence-based best practice medical care to our patients. Prof. Marco Bruno, Erasmus Medical Center Rotterdam, The Netherlands As a physician, I appreciate that Boston Scientific invests in clinical studies in order to develop and select the very best stents for patient care. The portfolio fulfills what each case needs. Prof. Thierry Ponchon, Hospital Edouard Herriot Lyon, France

5 2008 WallFlex Biliary RX First Platinol biliary stent 2008 Partially and Fully Covered First retrievable biliary stent 200 WallFlex Esophageal Fully Covered Stent First WallFlex Fully Covered Esophageal Stent 20 Benign indication for biliary stents in CE marked countries The WallFlex Biliary benign stricture indication*, supported by Boston Scientific s strong investment in clinical trials, gives confidence to physicians to place metal stents for a broad range of biliary strictures, including treatment of patients who would have previously waited for a confirmed diagnosis. The benign indication may help reduce the number of treatments per patient while potentially containing costs and providing the best possible care. Prof. Jacques Deviere, Erasme Hospital Brussels, Belgium * The benign indication is only available in CE Mark and OUS countries. Check with your local Boston Scientific representative for more information and product availability. The WallFlex [Colonic] Stent is a tremendous advancement in stent technology...these stents go around strictures very well without kinking. The lumen of the stent is not compressed by the stricture whatsoever and will follow the course of the lumen. Douglas Pleskow, MD, Beth Israel Deaconess Medical Center Boston, USA

6 2013 Over 1 Million Stents delivered worldwide over the past 20 years Boston Scientific provides value that extends beyond our products by delivering unsurpassed service and support to hospitals and physicians around the world. LAST YEAR ALONE, BOSTON SCIENTIFIC Hosted more than 800 preceptorships, local programmes and seminars worldwide Trained over 25,000 healthcare professionals 25k VALUE THAT EXTENDS BEYOND OUR PRODUCTS Trained more than 3,000 nurses in Europe as part of the nurse Professional Development Programme 1,700 Listening to You Conducted interviews with over 1,700 physicians, nurses, patients and economic customers Data on File - ENDO AB 5M November 2013

7 ORDERING INFORMATION Order Number Stent Diameter (mm) Stent Length (cm) Delivery System Working Length (cm) Delivery System Length (cm) Fully Covered Stent with Permalume Covering M M M M WallFlex Biliary Metal Stents Partially Covered Stents with Permalume Covering Uncovered Stents M M M M M M M M M M M M M M M00550 M WallFlex Enteral Metal Stents WallFlex Colonic Stent M00550 M M M M M M M M M M WallFlex Duodenal Stent M M

8 Order Number Stent Diameter (mm) Stent Length (cm) Delivery System Working Length (cm) Delivery System Length (cm) WallFlex Esophageal Metal Stents Ultraflex NG Esophageal Stents WallFlex Fully Covered Esophageal Stent WallFlex Partially Covered Esophageal Stent Ultraflex Covered Esophageal NG Stent Distal Release Ultraflex Covered Esophageal NG Stent Proximal Release Ultraflex Uncovered Esophageal NG Stent Distal Release Ultraflex Uncovered Esophageal NG Stent Proximal Release M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M M Permalume, Ultraflex, WallFlex and WALLSTENT are registered or unregistered trademarks of Boston Scientific Corporation or its affiliates. All other trademarks are the property of their respective owners. Indications, Contraindications, Warnings and Instructions for Use can be found in the product labeling supplied with each device. Caution: Law restricts these devices to sale by or on the order of a physician. The WallFlex Biliary Stent System is FDA-cleared in the US, and is indicated for use in the palliative treatment of biliary strictures produced by malignant neoplasms. The WallFlex Biliary Stent System is CE Marked (and approved in other regions check for local availability), and is indicated for the palliative treatment of biliary strictures produced by malignant neoplasms and the fully covered stents are also indicated for treatment of benign biliary strictures. Copyright 2013 by Boston Scientific Corporation or its affiliates. All rights reserved. ENDO AB MAY 2014