Surgery For Ebstein Anomaly
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1 Surgery For Ebstein Anomaly Christian Pizarro, MD Chief, Pediatric Cardiothoracic Surgery Director, Nemours Cardiac Center Alfred I. dupont Hospital for Children Professor of Surgery and Pediatrics Sidney Kimmel School of Medicine Thomas Jefferson University
2 No disclosures STS/EACTS Latin America Cardiovascular Surgery Conference
3 Ebstein Anomaly Morphology first described by Ebstein in 1866 TV leaflets variably adherent to RV myocardiaum Spectrum of disease Clinically documented by Taussig in 1950 Rare Bimodal age at presentation
4 Neonatal Ebstein s: Predictors of death Cardiothoracic ratio greater than 0.85 (100% fatal) Echocardiography score grade 4/4 (>1.5:1; 100% fatal) Echocardiography score grade 3/4 (>1.1:1) and cyanosis (100% fatal) Severe tricuspid regurgitation (mostly fatal) Echocardiography score grade 3/4 (>1.1:1; 45% fatal in infancy) Celermajer, DS. J Am Coll Cardiol 1992;19: Pavlova, M. Am Heart J 1998;135: Yetman, AT. Am J Cardiol 1998;81:
5 MRI evaluation Improved functional assessment RV and RA volumes RV function Delayed Enhancement Objectively assessment over time STS/EACTS Latin America Cardiovascular Surgery Conference
6 Indications for repair Symptoms Deteriorating exercise capacity Heart failure (NYHA class III-IV) Cyanosis Paradoxical embolism Progressive RV/RA enlargement New onset arrhythmias
7 Carpentier classification Anatomy is highly variable Anatomic variability continues to be a challenge for the surgeon
8 Ventricular dysfunction Ineffective LV filling due to to and fro flow into the right ventricle / right atrium Increase right atrial capacitance Pancaked Left ventricle RV myopathy Thinned out and fibrotic muscle
9 STS database: common interventions STS database analysis. Davies et al. Richard E Clark paper 2015
10 Center Experience Results 82 centers Median annual experience 1 case/yr (IQR ) Highest volume center: 8.3 cases/yr Neonates + infants 63 centers Median annual experience 0.5 cases/yr (IQR , maximum 5.2)
11 Arrhythmias are common among adult Ebstein anomaly Preoperative Risk Factor N (%) Any Preoperative Risk Factor 29/89 (32.6%) Acidosis 0/89 (0.0%) Arrhythmia 19/89 (21.4%) Shock 0/89 (0.0%) Mechanical Ventilation 0/89 (0.0%) Previous Cardiac Procedure 32/93 (34.4%) STS database analysis. Davies et al. Richard E Clark paper 2015
12 Surgical considerations Mechanism of TR, # of jets, location, valve morphology Delamination and tethering of each leaflet Leaflet edges, fenestrations Annular dilatation Size and function of the RV Ventricular septum and LV function Age of the patient
13 Danielson repair pts Monocusp Horizontal plication No sutures on the IVS 81% repair 2 pts (5%) had a Glenn 7.1% mortality Ann Thorac Surg.1982;196:
14 Carpentier Technique reposition the TV at the normal level Monocuspid or bicuspid reconstruct a normal shaped RV longitudinal plication of atrialized RV
15 JACC. 1991;17: pts (4-44 yrs) 9 repairs Bi leaflet valve Vertical plication No atrial reduction No annuloplasty ring No transection of PM No heart block No mortality f/u 11.7 mo
16
17 Common elements of TV repair Basic strategy Failures Monocusp repair (allows coaptation against the ventricular septum) based on anterior leaflet degree of a RV and annular dilatation tethering of the anterior leaflet Sebening stitch Due to focus on the annulus not on delamination Attempts to repair with poor valve anatomy marked linear attachment marked leaflet muscularization complete absence of septal leaflet. Massive annular dilatation Older age Pulmonary HTN STS/EACTS Latin America Cardiovascular Surgery Conference
18 J Thorac Cardiovasc Surg 2007;133:
19 Postoperative Outcome One (2.5%) hospital death and 1 late death in TR grade from 3.6 ± 0.5 to 1.2 ± 0.5 (P <.0001). At a mean follow-up of 4 years: Functional class (NYHA) improved from 2.6 ± 0.7 to 1.2 ± 0.4 (P <.0001). da Silva J. P. et al.; J Thorac Cardiovasc Surg 2007;133:
20 Valve inspection
21 Leaflet dettachement
22 Mobilization of all leaflet tissue (septal)
23 Annular reduction Ann Thorac Surg 2013;95:220 8
24 Reimplantation at the annular level Ann Thorac Surg 2013;95:220 8
25 Incorporation of septal leaflet
26 Leaflet augmentation STS/EACTS Latin America Cardiovascular Surgery Conference 2017 Ann Thorac Surg 2013;95:
27 Creation of neochordae (fenestrations) STS/EACTS Latin America Cardiovascular Surgery Conference 2017 Ann Thorac Surg 2013;95:220 8
28 Annuloplasty STS/EACTS Latin America Cardiovascular Surgery Conference
29 Leads to improved competency Circumferential leaflet coverage
30 Surgical technique Circumferential leaflet tissue repair (360) Valve anchored at the true annulus Ringed annuloplasty Leaflet augmentation Autologous chordae Bidirectional Glenn STS/EACTS Latin America Cardiovascular Surgery Conference
31 Commonly annular reduction is necessary/use pledgeted suture RCA runs in the right AV groove. Avoid kinking or occlusion of the RCA Liberal use of the Sebening stitch. Avoid dimple on the RV free wall (patch augmentation of the anterior leaflet) Plication of the RV should be confined to the smooth non trabeculated inferior wall. Avoid the IVS (PDArt) Decision about the feasibility of a good durable repair should be made early. Repair rate for adults is ~80%
32 Important considerations Aortic occlusion and cardioplegic arrest for precise suture placement, avoidance of coronary or conduction tissue injury, and minimizing motion trauma during suture placement. The time required to perform EA repair can be lengthy, even in experienced hands, and the consequences of prolonged operation in a patient with depressed ventricular function may not be prudent.
33 STS/EACTS Latin America Cardiovascular Surgery Conference
34 Summary Ebstein anomaly exhibits a broad range of anatomic features commonly leading to severe TR Due to morphologic variability, no perfect repair for all patients with EA The Cone reconstruction is the only technique that provides circumferential leaflet coverage and is highly effective to restore valve competency. Reduced right ventricular function continues to be a challenge, as is the need for reoperation for recurrent tricuspid regurgitation Steep learning curve requires institutional and surgeon experience for optimal outcomes Improved results should influence timing of repair. When severe RV dysfunction is present, TVR should be considered early.
35 Muchas Gracias!
36 Thank You
37 Your child. Our
38 Ebstein anomaly accounts for 1% of all congenital heart disease. It is a right ventricular myopathy with failure of tricuspid valve delamination and highly variable tricuspid valve morphology that usually results in severe regurgitation. It is the only congenital heart lesion that has a range of clinical presentations, from the severely symptomatic neonate to an asymptomatic adult. Neonatal operation has high operative mortality, whereas operation performed beyond infancy and into adulthood has low operative mortality. Late survival and quality of life for hospital survivors are excellent for the majority of patients in all age brackets. Atrial tachyarrhythmias are the most common late complication. There have been more techniques of tricuspid repair reported in the literature than any other congenital or acquired cardiac lesion. This is largely due to the infinite anatomic variability encountered with this anomaly. The cone reconstruction of Ebstein anomaly can achieve near anatomic restoration of the tricuspid valve anatomy. Early and intermediate results with these repairs are promising. Reduced right ventricular function continues to be a challenge for some patients, as is the need for reoperation for recurrent tricuspid regurgitation. The purpose of this article is to outline the current standard of care for diagnosis and treatment of Ebstein anomaly and describe innovative strategies to address poor right ventricular function and associated right-sided heart failure.
39 SLIDE TITLE HEADLINE Subtitle Bullet number one Bullet number two Sub-bullet number three Sub-bullet number four Bullet number five Description of Graph or Table 1st Qtr 2nd Qtr 3rd Qtr 4th Qtr STS/EACTS Latin America Cardiovascular Surgery Conference
40 SLIDE TITLE HEADLINE Series 1 Series 2 Series Category 1 Category 2 Category 3 Category 4 STS/EACTS Latin America Cardiovascular Surgery Conference
41 SLIDE TITLE HEADLINE STS/EACTS Latin America Cardiovascular Surgery Conference
42 C RV unloading, decreases RV dilatation Improves LV/RV interaction Increases effective LV filling (Cardiac output) Allows tighter annuloplasty Not feasible in neonates and youg infants Chaveaud et al. EJCTS 1998;13:
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