Positive pressure ventilation in cardiogenic shock: friend or foe?
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1 Positive pressure ventilation in cardiogenic shock: friend or foe? ACCA Masterclass 2017 Josep Masip MD, PhD, FESC Disclosures: Novartis advisor, ThermoFisher consultant, Philips and Orion speaker fees, Menarini travel-congress support
2 Respiratory disorders in cardiogenic shock Increase in dead-space (fall in pulmonary perfusion) Shunt effect (pulmonary edema - hypoxemia) Ventilation-Perfusion inequality (respiratory failure) Tissue hypoperfusion (Altered mental status) (Lactacidemia - metabolic acidosis A-V difference- SVO2 Respiratory muscle dysfunction (Hypoventilation Hypercapnia) Pulmonary inflammation (Cytokines release SIRS) Tachypnea Increasing work of breathing
3 MAIN GOALS OF MECHANICAL VENTILATION IN SHOCK Establish an adequate airway (CNS) Reduce VO2 (work of breathing) Improve oxygenation Reverse respiratory acidosis (hypercapnia) Decrease sympathetic tone Improve tissue perfusion and metabolic acidosis
4 Effects of MV in the thorax Spontaneous breathing Mechanical Ventilation Negative pressure Positive pressure Atmospheric pressure
5 BENEFICIAL EFFECTS OF POSITIVE INTRATHORACIC PRESSURE RESPIRATORY Recruitment of collapsed alveolar units Increase of FRC Maintenance of continuously opened alveoli Gas exchange during the whole respiratory cycle Intra-alveolar pressure against edema Decrease work of breathing Improvement in oxygenation HEMODYNAMIC Decrease in pulmonary shunt Alveolus
6 Decrease Preload RV - LV OTHER HEMODYNAMIC CHANGES WITH POSITIVE INTRATHORACIC PRESSURE Systemic hypotension Reduction CO Fluid retention In AHF it may Increase cardiac output Increase RV Afterload Reduction Compliance LV Martin J Tobin. NEJM 2001
7 ACCA Masterclass 2017 Let's have a look at the real world
8 Califf R. NEJM 1994 Topalia S, et al Crit Care Med 2008
9 CARDSHOCK STUDY N = 220
10 Causes of Cardiogenic shock 20 % 80 % N=220 Acute Coronary Syndrome Other causes Harjola V-P. Eur J Heart Fail 2015
11 Harjola V-P. Eur J Heart Fail 2015
12 7.6% 5.8% CAUSES OF MECHANICAL VENTILATION IN ACS 1231 STEMI 1821 ACS 10 (9.5%) 64 (60.4%) 32 (30.1%) Lazzeri Ch. Cardiol J 2013 AHF Shock Cardiac Arrest p n=27 (26%) n=14 (13%) n=65 (61%) Age Diabetes HTA Smoker In hospital ETI (%) NIV Swan Ganz (%) IABP (%) Renal RT (%) Major bleeding (%) Transfusions (%) In H mortality (%) Mortality (%) Non-card. Mortality Ariza A. Eur Heart J Acute Card Care 2013
13 USA National Inpatient Sample (NIS) from 2002 to 2013: STEMI IMV (3.9%) and NIV (0.4%) average annual rate of 6.6% 44.7% 11.6% 37.6% 6.8% average annual rate of 14.3% Metkus T. Am J Cardiol 2013
14 SHOCK Trial Mechanical ventilation (88 %) 83% Mechanical ventilation (78 %) Hochman J et al. NEJM 1999
15 Percentage of use Oxygen Therapy in Card-Shock Study 61% 26% 13% Hongisto M. International J Cardiol 2017
16 CHARACTERISTICS OF THE PATIENTS WITH CS ACCORDING TO THE TYPE OF OXYGEN THERAPY Blood analysis MV NIV Oxygen p (n = 137) (n = 26) (n = 56) Hemoglobin (g/l) Arterial lactate (mmol/l) Hs-TroponinT (ng/l) NT-proBNP (pg/ml) Creatinine (mmol/l) egfr (ml/min/1.73 m2) CRP (g/l) Hongisto M. International J Cardiol 2017
17 Baseline arterial blood gases CHARACTERISTICS OF THE PATIENTS WITH CS ACCORDING TO THE TYPE OF OXYGEN THERAPY MV NIV Oxygen p (n = 137) (n = 26) (n = 56) ph <0.001 PaO2 (mm Hg) PaCO2 (mm Hg) HCO3 mmol/l FiO2 (%) PaO2/FiO2 (mm Hg) n (%) n (%) <100 n (%) Hongisto M. International J Cardiol 2017
18 CHARACTERISTICS OF THE PATIENTS WITH CS ACCORDING TO THE TYPE OF OXYGEN THERAPY Devices and outcomes MV NIV Oxygen p (n = 137) (n = 26) (n = 56) Coronary angiogram 114 (83) 23 (89) 45 (80) 0.8 PCI 90 (66) 19 (73) 40 (71) 0.5 CABG 5 (4) 3 (12) 1 (2) 0.1 IABP 85 (62) 16 (62) 21 (38) 1.0 In-hospital mortality 62 (45) 5 (19) 13 (23) day mortality 67 (49) 7 (27) 15 (27) 0.03 ICU/CCU (days) In-hospital (days) Hongisto M. International J Cardiol 2017
19 CHARACTERISTICS OF THE PATIENTS WITH CS ACCORDING TO THE TYPE OF OXYGEN THERAPY Clinical Findings MV NIV Oxygen p (n = 137) (n = 26) (n = 56) Systolic BP (mmhg) Heart rate (b/m) LVEF (%) Confusion n (%) Hongisto M. International J Cardiol 2017
20 Disadvantages of mechanical ventilation ACCA Masterclass 2017
21 Disadvantages of mechanical ventilation Artificial airway (intubation-tracheostomy) Need for Sedation Initial hypotension Atrophy (ciliar) Ventilator lung injury Diaphragmatic dysfunction Ventilator associated pneumonia Increased RV afterload Acute Cor Pulmonale
22 Inconvenients of Tracheal Intubation At the time of Intubation Gastric aspiration Barotrauma Hypotension and arrhythmias Sedation Local trauma (dental, pharynge, larynge or trachea) Related to Extubation Dysphagia, odinophagia or dysphonia Hemoptisis Obstruction (chordae dysfunction/edema) Tracheal stenosis Tracheostomy Hemorrhage Infection or obstruction False lumen Mediastinitis Lesions in trachea, esophagus and blood vessels
23 INTUBATION BP TIME
24 ENDOTRACHEAL INTUBATION IN ACS : 458 patients Germany (BEAT registry) : 106 patients Barcelona Primary PCI 74% In-hospital 60% Pre-hospital In-hospital Pre-hospital 66% Mortality 48% Mortality 29% Kouraki K. Clin Res Cardiol 2011 Ariza et al. EHJ Acute Cardiovasc Care 2013
25 INTUBATION CARE BUNDLE MANAGEMENT Jaber S, et al. Intensive Care Med 2010
26 VENTILATOR - ASSOCIATED EVENTS CDC surveillance paradigm (2013) Incidence rates range: events per ventilator-days or 4 7 events per 100 episodes of MV VAEs are approximately twice as likely to die, associated with more time on MV, longer ICU stays, and higher rates of antimicrobial use Klompas. Am J Resp Crit Care 2015 ACCA Masterclass 2017
27 Ventilator Associated Events (VAEs) NEW PARADIGM at least 2 days of stable or decreasing ventilator settings followed by at least 2 days of increased ventilator settings PEEP : 3 cm H2O (FIO2) of at least 20 points ACCA Masterclass 2017
28 Clinical Events Associated with Ventilator-associated Events PNEUMONIA, EXCESS FLUID, ATELECTASIS, and/or ARDS ACCA Masterclass 2017
29 Three major approaches to prevent VAEs: (1) Avoid intubation: Use of NIV (2) Minimize duration of MV (3) Target the specific conditions that most frequently trigger VAEs ACCA Masterclass 2017
30 1. Minimize Sedation Sedation protocol (RASS Scales, Frequent controls) Decrease the use of benzodiacepines vs No sedation, propofol, remifentanil and dexemedetomidine Agitated delirium Self-extubations Staffing requirements Emergency reintubations Pneumonia risk Time to extubation
31 2. Daily Spontaneous Awakening Trials and Breathing Trials Weaning protocol 30 min to 2 h of SBT or Pressure Support Ventilation Reconnect Ventilation for 1 h before extubation ACCA Masterclass 2017
32 3. Programs of Early Exercise and Mobility Physiotherapists Mobilization protocol Nurse training Family collaboration ABCDE package Awakening and Breathing Coordination Delirium monitoring and management Early exercise and Mobility ACCA Masterclass 2017
33 Family collaboration Happ MB. Heart Lung. 2007
34 4. Appropriate ventilation strategy Lung protective strategy 10 ml/kg Tobin. M, N Engl J Med 2001
35 Appropriate ventilation strategy Low tidal volumes (6-7 ml/kg) Higher frequencies Adjust PEEP Low plateau pressure (<27cmH2O) and driving pressure (<17cmH2O) Permissive, but controlled hypercapnia Meassures to prevent VAP Avoid F I O 2 >0.6 Prone position
36 5. Conservative Fluid Management 20 40% of VAEs are attributable to fluid overload including congestive heart failure, pulmonary edema and new pleural effusions Physical examination, CVP, PCWP, extravascular lung volume, mean arterial pressure, urinary output, cardiac index, IVC, E/E ACCA Masterclass 2017
37 Central Venous Pressure and Fluid Responsiveness A Systematic Review Marik PE et al. Chest 2008
38 Pulse Pressure Variation with respiration Michard F. Am J Respir Crit Care Med 2000
39 Pulse Pressure Variation (PPV) Conditions: Mechanical ventilation No arrhythmia No spontaneous breathing Constant Vt 7 ml/kg RR < 30 No RVF Mahjoub Y et al Br J Anesthesia 2013
40 Passive Leg Raising PLR and LVOT VTI (TTE) 12% PLR and SV (TTE) 12.5% predicts SV 15% after volume load (Sens. 77%; Spec. 100%) Monnet X. Intensive Care Med 2008 Lamia: Intensive Care Med 2007
41 Other methods : End-expiratory occlusion test 15s occlusion at end-expiration PP or PCA-CO 5% Sens 87%, Spec 100% for response to 500 ml Minifluid challenge 100 ml of colloid/1 min: LVOT VTI 10% Sens 95%, Spec 78% for response to volume Monnet X, Crit Care Med 2012 Muller L, Anesthesiology 2011
42 6. Conservative Blood Transfusion Thresholds ACCA Masterclass 2017
43 7. Ventilator Associated Pneumonia Prevention Oral care with chlorhexidine Subglottic secretion drainage Unlikely Elevating the Head of the Bed Hand washing Disposable gloves Sterile aspiration Likely Campaigns: Pneumonia Zero, Bacteremia Zero, Resistance Zero VAP: from 15/1000days MV to 5/1000 daysmv
44 Characteristics of Patients With Complicated ACS Requiring Prolonged Mechanical Ventilation 267 patients Zahger D. Am J Cardiol 2005
45 Percentage COMPLEMENTARY EFFECTS OF MV AND IABP IABP- Shock Trial 45 patients AMI-PCI shock randomized to IABP % IABP 67% Medical Mechanical ventilation No-Mechanical Ventilation Prondzinsky R et al, Crit Care Med 2010
46 COMPLEMENTARY EFFECTS OF MV AND IABP Liu H. J International Med Res 2016
47 CONCLUSIONS MV is a good friend that has saved millions of lives In patients with CS it should be used in cases with severe respiratory failure or altered mental status that can not be managed by other ways The appropriate use of the technique targeted to shorten the duration of MV and avoiding ventilator events is essential to sustain this friendship
48 Thank you for your attention
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