UPMC Critical Care
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1 UPMC Critical Care
2 Shock and Monitoring Samuel A. Tisherman, MD, FACS, FCCM Professor Departments of CCM and Surgery University of Pittsburgh
3 Shock Anaerobic metabolism Lactic acidosis Dysoxia Activation of inflammatory cascades Inadequate DO 2 Organ system dysfunction
4 Shock Normal cardiovascular system Pathophysiology of shock Categories of shock Resuscitation Monitoring
5 Key components of CV system Intravascular volume Cardiac output Preload Heart rate Contractility Afterload
6 Key components of CV system Resistance circuit arterioles Distribution of organ flow Capillaries Leak Obstruction to flow Shunts Venous capacitance vessels Vary venous return
7 Organ blood flow Most dependent upon mean arterial pressure (MAP) Autoregulation Maintained during large variations of MAP mmhg Can be impaired - hypertension
8 Autoregulation
9 Supply and demand O 2 delivery Hemoglobin Saturation Cardiac output O 2 demand 20-60% VO 2 = DO 2 x ERO 2 ER = extraction ratio
10 O 2 supply dependency Oxygen consumption Critical DO2 Critical DO2 Dysoxia Lactic acidosis Oxygen delivery
11 Cytopathic Hypoxia Sepsis Normal oxygen delivery Impaired mitochondrial O 2 utilization Mediators Inflammatory cytokines Inhibition of pyruvate dehydrogenase Inhibition of cytochrome a,a3 by NO Irreversible inhibition of one or more mitochondrial respiratory complexes by peroxynitrite Poly(ADP-ribose) polymerase-1
12 Reperfusion Injury ATP Ischemia Hypoxanthine Reperfusion O 2 Xanthine Dehydrogenase Xanthine Oxidase Oxygen radical formation Lipid mediator release Tissue injury Endothelial cell dysfunction Neutrophil chemotaxis Microvascular changes
13 It s not the fall that gets you.
14 Organ failure Ischemic Injury Organ Damage Reperfusion injury Inflammatory mediators (TNF, NO, free radicals)
15 Classifications of shock Hypodynamic Low CO (narrow PP) No No Hypovolemia Hemorrhage Dehydration Pulmonary edema? JVD? Yes RV failure Obstructive PE Tamponade PTX Hypotension Yes Cardiogenic shock MI Valvular dz Hyperdynamic Low SVR (wide PP) Distributive shock Sepsis Neurogenic shock Adrenal insufficiency Liver failure Anaphylaxis Medications
16 Hemorrhagic shock Most common cause of hypotension in trauma patients Initial fluid should be crystalloid Transfusion Hypotensive after 2 L crystalloid (ATLS) Earlier for severe shock Uncontrolled hemorrhage Stop hemorrhage Limited fluid resuscitation
17 Cardiogenic shock Resuscitation simultaneous with revascularization Patients may need higher than normal filling pressures (poor LV compliance) Inotropes may worsen ischemia Pacing may be helpful for relative bradycardia Intra-aortic balloon pump improves coronary perfusion and decreases afterload
18 Pulmonary embolism Risk factors Hypercoagulability, stasis, trauma Presentation Respiratory Cardiovascular Diagnosis CT angio, VQ, echo, angio, d-dimer Management Anticoagulation, thrombolytic, embolectomy Prevent the next one -?filter
19 Cardiac tamponade Pentrating trauma more common than blunt Beck s triad (hypotension, distant heart sounds, JVD) obscured by hypovolemia High index of suspicion Diagnose: echo or pericardial window Treatment: Need sternotomy or thoracotomy (trauma) Pericardiocentesis (non-trauma)
20 Septic shock Decreased preload Hypovolemia (capillary leak) Increased venous capacitance Vasodilatation Cardiac dysfunction Ventricular dilatation Decreased ejection fraction Cytopathic hypoxia
21 Endstage shock Cardiac decompensation Irreversible shock Vasomotor dysfunction Terminal hypodynamic state
22 Initial management
23 Initial management Resuscitation Ventilation?intubation early Infusion Bolus to effect?blood Clear lactate Pump therapy Inotropic support Afterload reduction Vasodilatation Vasopressor support Definitive therapy Stop bleeding Circulatory assist Antibiotics and drainage/debridement
24 Monitoring
25 CVP Only elevated in disease RV dysfunction Pulmonary hypertension LV dysfunction Tamponade Hyperinflation Intravascular volume expansion Poor correlation with volume responsiveness
26 PAOP and Preload Muscle LVEDV LVEDP LAP PAOP
27 CVP and PAOP Kumar, et al. CCM, 2004.
28 Functional Hemodynamic Monitoring 2-3 heart beats later
29 Resp variation in pulse pressure Limitations: spontaneous breathing, arrhythmias. Michard and Teboul. Crit care, 2000.
30 Passive Leg Raising
31 Passive Leg Raising Monnet, et al. CCM, 2012.
32 Preload Echo Distensibility index Max-min D IVC x 100% Min D IVC Collapsibility index Max-min D IVC x 100% Max D IVC Resp variability index ΔD IVC = Max-min D IVC x 100% Mean D IVC Feissel, et al. Intensive Care Med, 2004.
33 Mixed venous oxygen - SvO2 Decrease SvO 2 Decrease DO 2 Hb, O 2 sat, cardiac output Increase O 2 demands Fever, sepsis, exercise Normal >65% Critical value ~40% Resuscitation endpoint for sepsis and cardiogenic shock Sepsis -> maldistribution of blood flow SvO 2 normal with tissue dysoxia still present
34 Oxidative Metabolism Mitochondria 2 ATP Glucose Pyruvate Acetyl CoA Lactate 2 ATP Citric acid Cycle Remember 2:38 NADH/FADH2 Electron transport chain ADP 34 ATP O 2 H 2 O
35 Base Deficit Definition Amount of base needed to normalize ph with normal PCO 2 Limitations Administration of bicarbonate Alcohol intoxication Hyperchloremic metabolic acidosis Seizures Pre-existing acidosis
36 Lactate Excess production Anaerobic metabolism Initial level and time to clearance useful Decreased metabolism (liver, kidney) Washout during reperfusion Sepsis Increase flux of alanine from muscle Decreased PDH activity Decreased hepatic clearance Dysfunctional mitochondrial respiration
37 Near Infrared Spectroscopy Measurements PO 2 PCO 2 ph O 2 saturation of hemoglobin Tissue oxyhemoglobin coupling to cytochrome a,a3 redox Mitochondrial O 2 Location Muscle Stomach Bowel Liver
38
39 Hypodynamic Low CO (narrow PP) No No Hypovolemia Hemorrhage Dehydration Fluids Blood Hemostasis Pulmonary edema? JVD? Yes RV failure Obstructive PE Tamponade PTX Fluids Inotropes Specific Tx Hypotension Yes Cardiogenic shock MI Valvular dz Inotropes IABP Revascularize Hyperdynamic Low SVR (wide PP) Distributive shock Sepsis Neurogenic shock Adrenal insufficiency Liver failure Anaphylaxis Medications Fluids Vasopressors EGDTx Treat cause Base deficit Lactate SvO 2
40 UPMC Critical Care
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