Evidence Based EMS: The Science Behind Your Care
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1 Evidence Based EMS: The Science Behind Your Care Sean Kivlehan, MD, MPH, NREMT-P September 2016
2 RESPONSE AIRWAY BREATHING CIRCULATION DISABILITY
3 RESPONSE AIRWAY BREATHING CIRCULATION DISABILITY
4 Eisenberg, JAMA 1979 Less than or equal to 8 minutes at least 90% of the time 1979 study only looking at cardiac arrest Somehow generalized to everything Likely irrelevant even for arrests now with PAD programs (to their credit)
5 Denver EMS, 1998 all calls (49,851) Survival benefit for < 4min, but not 8 High risk arrests Medium risk: Suicide Exposures Uncon Diff breather Hypotension Pons, Acad Emerg Med 2005
6 The Golden Hour 3,656 trauma patients in 146 agencies SBP <90 RR <10 or >29 GCS <13 Advanced airway intervention Newgard, Ann Emerg Med 2010
7 No association btw time & mortality for any EMS intervention (OR 1.00, 95% CI ) Response, On-Scene, Transport, total EMS time
8 Not so fast (or slow ) Orange County ,167 patients; 84% blunt, 16% penetrating McCoy, Ann Emerg Med 2013
9 How Many Ambulance Accidents per Year? A. 1,000 B. 5,000 C. 10,000 D. 20,000 E. 30,000
10 Risk vs Benefit Only condition in which rapid EMS response shown to improve survival: Nontraumatic Cardiac Arrest Risk of Lights & Sirens to public 12,000 ambulance accidents/year 75,000 wake effect accidents Clawson, JEMS 1991; Waldran, Analysis of Red Lights & Sirens 2008
11 CDC Report, fatal ambulance accidents 816 ambulance occupants involved, 82 died. 275 occupants of other vehicles or pedestrians killed Injury rate for EMS personnel in the United States is 12.7 per 100,000 workers more than twice the national average. MMWR, 2003
12 L&S time difference Responding ambulance followed by chase car (urban): 64 runs: 38.5% (3.02 minutes) time savings utilizing red lights and sirens [Ho & Casey, Ann Emerg Med 1998] Responding ambulance followed by chase car (rural): 67 runs: 30.9% (3.63 minute) time savings [Ho & Lindquist Prehosp Emerg Care 2001] Likely inflated numbers disrupted traffic patterns from initial ambulance response.
13 Removing Confounders Off-duty paramedic drives identical ambulance: Same route, same time of day Study #1: 43.5 seconds saved Study #2: 1 minute and 46 seconds saved While statistically significant, this time saving is likely to be clinically relevant in only a very few cases. Hunt, Brown, Cabinum, et al, Ann Emerg Med 1995 Brown, Whitney, Hunt, Addario, and Hogue, Prehosp Emerg Care, 2000
14 Helicopters Advantages: Faster transport Expert care both enroute & on arrival Disadvantages: Cost Safety
15 Cochrane Review, studies Overall the quality of the included studies was low Helicopter transport for some trauma patients may be beneficial for a variety of reasons and more research is required to determine what elements of helicopter transport help improve outcomes.
16 Sampling of Studies Stewart (AEM 2011): Decreased mortality for critical patients but extensive overtriage w/no benefit (Oklahoma) de Jongh (Injury 2012): Increased mortality for TBI patients due to transport time, no sig outcome change for all others (Netherlands) Taylor (BMC EM 2013): Overtriage, majority of patients have minor injuries (Australia)
17 What percentage are discharged from the ER? 1. 10% 2. 15% 3. 20% 4. 25% 5. 30% Bledsoe, J Trauma 2006
18 What percentage are discharged from the ER? 1. 10% 2. 15% 3. 20% 4. 25% 5. 30% Bledsoe, J Trauma 2006
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20 Pro Argument Galvagno (JAMA 2012): Reduced mortality in major trauma (Maryland) 65 transports to save 1 life Cost per flight $5,000 Cost per life $325,000
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23 What should be done in the field (and what shouldn't be)
24 RESPONSE AIRWAY BREATHING CIRCULATION DISABILITY
25 AIRWAY INTUBATION
26 ETI vs SGA Witnessed nontraumatic OHCA x4 years in Japan 5,377 patients Favorable neuro outcome 3.6% vs 3.6% Longer time to placement for ETI: 17.2 vs 15.8 min (p<0.001) Kajino, Crit Care 2011
27 Out of Hospital Airway Management in the United States NEMSIS data from 16 states in million EMS calls 10,356 ETI: success 77% (Hubble, 2010 showed 86.3% in meta-analysis of 30 studies) 1,794 alternate airways: success 87% [Combitube, EOA, LMA, King LT] Wang, Resuscitation 2011
28 Out of Hospital Airway Management in the United States NEMSIS data from 40 states in million EMS calls 74,993 ETI: success 85% (Hubble, 2010 showed 86.3% in meta-analysis of 30 studies) 21,990 alternate airways: success 79% [King LT 89%, EOA 38%] Diggs, Resuscitation 2014
29 Japan Again 5 year observational study 649,359 patients 43% with airway WORSE neuro outcome 1.1% vs 2.9% (OR 0.38) Hasegawa, JAMA, 2013
30 Need four providers Team leader/intubator Supplies & meds Removing c-collar & holding cricoid Holding in line stabilization SGA should be first line Capnography Effect of scene time Do It Right
31 C-MAC Video Laryngoscope Higher first-pass rate Increased speed to intubation Reduced c-spine movement when compared with DL Healy, BMC Anest 2012
32 RESPONSE AIRWAY BREATHING CIRCULATION DISABILITY
33 BREATHING OXYGEN PNEUMOTHORAX
34 ACS Workup 1. Morphine 2. Oxygen 3. Nitro 4. Aspirin
35 Oxygen = Harm? O Conner, Resuscitation 2010; Cochrane Review 2013
36 BREATHING OXYGEN PNEUMOTHORAX
37 Tension Pneumothorax
38 Length! Need AT LEAST 14 gauge, 3.25 inch long Source: Academic Life in EM
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40 RESPONSE AIRWAY BREATHING CIRCULATION DISABILITY
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47 CIRCULATION CAPNOGRAPHY COMPRESSIONS HYPOTHERMIA ACCESS MEDICATIONS
48 Question What is the stronger predictor of ROSC? A: Witnessed Arrest B: Initial ETCO2 of 13
49 Termination & Capnography Associated with ROSC: Witnessed Arrest (OR = 1.51) Initial EtCO2 >10 (OR = 4.79) No ROSC: No bystander CPR, unwitnessed collapse, non- VF/VT arrest, initial EtCO2 <10 97% predictive of no ROSC Eckstein, Prehosp Dis Med 2011
50 Who Would Call It? 65F in cardiac arrest Witnessed Immediate bystander CPR VF earlier, shocked x1, asystole since ACLS per protocol Intubated, PIV 24 minutes down time EtCO2 8
51 Termination Rules If ANY criteria are present But, How Long? Morrison, Resuscitation 2009
52 20 minutes? 150 patients in Washington in the 90 s 20 minutes Survivors: 32.8 Non-survivors: 4.4 Levine, NEJM 1997
53 Capnography A guide to: 1. Likelihood of ROSC GOOD: Abrupt & sustained increased to BAD: <10 is a poor predict 2. Airway confirmation 3. CPR quality (Goal >20)
54 CIRCULATION CAPNOGRAPHY COMPRESSIONS HYPOTHERMIA ACCESS MEDICATIONS
55 What they already knew: Compressions affected ventilation If alone, only do compressions Only the human hand is required
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58 Systolic Blood Pressure Compressions Time (Seconds)
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63 Ewy, JACC 2013
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65 114 EMS Agencies 23,711 patients 7.0% vs 7.7% fav. Neuro survival
66 CIRCULATION CAPNOGRAPHY COMPRESSIONS HYPOTHERMIA ACCESS MEDICATIONS
67 In Hospital 2002 Study #1: 77 patients randomized to 33 C x12 hours Favorable neuro outcome: 49% (chilled) vs 26% (not) Study #2: 136 patients randomized to C x24 hours Favorable neuro outcome: 55% (chilled) vs 39% (not) Bernard, NEJM 2002; Hypothermia Study Group, NEJM 2002
68 Is Colder Better? 33 vs 36 targeted temperature 939 patients No difference in survival Overall survival better vs 2002 Nielsen, NEJM 2013
69 Is Faster Better? PreHospital Cooling vs In-hospital 1359 patients in VT/VF No difference in survival Slightly worse outcomes Kim, JAMA 2013
70 Targeted Temperature Management All comatose patients for 24 hours degrees Celsius Not recommended in field AHA Guidelines 2015
71 CIRCULATION CAPNOGRAPHY COMPRESSIONS HYPOTHERMIA ACCESS MEDICATIONS
72 Question What is your first line? A. PIV B. IO
73 IO as first line in arrest? [182 arrest patients] 1 st attempt success: Tibial IO: 91% Humeral IO: 51% PIV: 43% Time to initial success: Tibial IO: 4.6 min Humeral IO: 7.0 min PIV: 5.8 min Reades, Ann Emerg Med 2011
74 2 nd IV Line? No change in mortality, GCS, SBP, or anything No evidence to support Not risk-free: Needle stick Infection Vascular Injury Nerve injury Merlin, Prehosp Emerg Care 2011
75 CIRCULATION CAPNOGRAPHY COMPRESSIONS HYPOTHERMIA ACCESS MEDICATIONS
76 Question What Medications Work in ACLS? A. Epinephrine B. Atropine C. Bicarbonate D. Amiodarone E. Lidocaine F. None of the Above
77 Norway IV drugs vs no IV drugs 6 years, 851 patients ROSC: 32% vs 21%: BETTER Survival to discharge: NO CHANGE Favorable Neuro Outcome: NO CHANGE Olasveengen, JAMA 2009
78 Western Australia Epi vs Placebo 4 years, 534 patients ROSC 23.5% vs 8.4%: BETTER Survival to discharge: NO CHANGE Jacobs, Resuscitation 2011
79 Japan Epi vs Nothing 4 years, 417,188 patients ROSC: 18% vs 5%: BETTER 1 month survival: NO CHANGE Good functional status: 1.4% vs 2.2% WORSE Hagihara, JAMA 2012
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81 Bottom Line there is no placebo-controlled study that shows that the routine use of any vasopressor during human cardiac arrest increases survival to hospital discharge. There is no convincing evidence that the routine use of other drugs (atropine, amiodarone, lidocaine, procainamide, bretylium, magnesium, buffers, calcium, hormones, or fibrinolytics) during human CPR increases survival to hospital discharge. There was no clear advantage of epinephrine the efficacy of vasopressor use in OHCA remains unanswered. Morrison, Circulation 2010; Lin, Resuscitation 2014
82 PARAMEDIC 2: The Adrenaline Trial RCT in UK Started December 2014 Results expected in 2018
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84 Ontario PreHospital Advanced Life Support (OPALS) Study Survival to Discharge Odds Ratios 1. Bystander CPR: Rapid Defibrillation: Paramedics with ACLS: 1.1 Stiell, NEJM 2004
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86 RESPONSE AIRWAY BREATHING CIRCULATION DISABILITY
87 DISABILITY HEAD INJURIES BLS CARE FIELD REPORTS
88 Head Injury Hypotension: 1 episode: OR 2.1 for death 2 or more: OR 8.1 for death Manley, Arch Surg 2001
89 Question 75F fell out of bed Lift Assist No visible Trauma On Coumadin Does she need to go to the ER?
90 Head Injury Head Bleed in GCS 15 patient: Plavix: 12% Coumadin: 5% Nishijima, Ann Emerg Med 2012
91 DISABILITY HEAD INJURIES BLS CARE FIELD REPORTS
92 ALS vs BLS for Trauma Ontario Prehospital Advanced Life Support (OPALS) Major Trauma Study Before-After Study No Change in Survival Survival worse for GCS <9 60% vs 50% w/ ALS Stiell, CMAJ 2008
93 DISABILITY HEAD INJURIES BLS CARE FIELD REPORTS
94 Field Reports Normotensive patient in the ED with reported field hypotension 37% had emergent surgery, 6% died If no report of hypotension 11% had emergent surgery, 3% died Lipsky, J Trauma 2006
95 SUMMARY 1 of 3 1. Scene Times penetrating trauma 2. Lights & Sirens risk > benefit 3. Helicopters risk = benefit? 4. Intubation SGA s & video 5. Oxygen harm > help? 6. Tension PTX longer needle
96 SUMMARY 2 of 3 1. Capnography - helpful 2. Compressions - work 3. Hypothermia questionable 4. Access IO first 5. Medications - dogma
97 SUMMARY 3 of 3 1. Head Injury avoid low BP 2. Blood Thinners need a CT 3. Trauma BLS > ALS 4. Field Reports - matter Sean.Kivlehan@gmail.com
in Cardiac Arrest Management Sean Kivlehan, MD, MPH May 2014
in Cardiac Arrest Management Sean Kivlehan, MD, MPH May 2014 1. Capnography 2. Compressions 3. CPR Devices 4. Hypothermia 5. Access 6. Medications Outline Capnography & Termination Significantly Associated
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