Team 19 Kaitlyn Clarke Brittany DePoi Andrew Reynolds Adarsha Selvachandran. Client: Dr. Wei Sun
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1 Team 19 Kaitlyn Clarke Brittany DePoi Andrew Reynolds Adarsha Selvachandran Client: Dr. Wei Sun
2 Dr. Sun has requested a testing device that will allow his research team to obtain physical evidence regarding the response of cardiac tissue to implantation of the Percutaneous Mitral Annuloplasty System for the Treatment of Mitral Regurgitation ( aka. stent bridge constriction device ) Figure 1: Summary of Theoretical Analysis Obtained by Tissue Mechanics Lab
3 Mitral Valve Regurgitation The Constriction Device The Testing Device o Water Bath o Marker Tracking System o Force Detection System o Ultrasonic Detection Budget
4 Mitral Valve Regurgitation Mitral valve regurgitation is the backwards flow of blood through the mitral valve. anteromedial It is caused by mitral valve prolapse (widening of the mitral valve annulus). This leads to a gap between the anteromedial and posterolateral leaflets of the mitral valve. posterolateral The condition is predominate in the elderly. Therefore, clinicians are turning to non-invasive methods to better address the condition. Figure 2: Difference Between Healthy and Prolapsed Heart Valve
5 Implanted percutaneously Catheter guides the device into the coronary sinus Distal anchor is deployed first followed by proximal anchor Nitinol bridge between stents constricts coronary sinus, thus closing the mitral valve annulus Distal Anchor Nitinol Bridge Proximal Anchor Figure 3: PTMA Device Deployment and Effect on the Mitral Valve
6 Required project components: Water Bath Marker Tracking System Force Determination System Ultrasonic Detection Figure 4: Compilation of Project Components
7 Purpose: support heart and simulate naturally occurring environmental conditions such as temperature, pressure, and heart orientation 3 main components: o Water bath o Heart mount o Heart pressure system Figure 5: Water Bath
8 Secure enough to hold heart stable Loose enough to allow heart to move naturally in response to the stent bridge constriction device Aluminum base will squeeze the base of the heart to provide structural support Aorta Tube Base Aorta tube must securely hold heart and maintain internal pressure of heart without effecting the integrity of the system Figure 6: Heart Mount System
9 Note proximity of the aortic valve and anteromedial mitral leaflet Anteromedial leaflet of mitral valve Aorta Figure 7: Picture Depicting Heart Valve Locations
10 Water Bath o 8 x 8 x 10 o Clear cast acrylic sheets Camera Mount o Aluminum o Adjustable (height, angle and horizontal location) Figure 8: Water Bath and Camera Mount
11 Purpose: Understand mechanical changes experienced by heart during stent deployment small graphite markers on mitral annulus plane 2 cameras degrees apart to capture image Calibration Cube in field of view of each camera Figure 9: Mitral Annulus Plane
12 Direct linear transformation (DLT) MATLAB code o Recreate image with reference to the three-dimensional plane o Determine the 3-D position of each marker o Keep track of each marker and it s movements from frame to frame o Recognize if a marker leaves the frame of view of one of both cameras o Calculate stress, strain, and deformation
13 Figure 10: View From Camera of Mitral Annulus Plane Mitral Annulus Plane
14 Purpose: Determine relationship between force applied on the mitral annulus by stent and the decrease in mitral valve prolapse FlexiForce Sensors o o Figure 11: FlexiForce Sensor Force measured at specific point as opposed to continuous Use 6 sensors in an attempt to get more thorough data Figure 12: FlexiForce Circuit
15 Coronary Sinus Mitral Valve (open) Aortic Root Figure 13: Location of Coronary Sinus (where FlexiForce Sensors will be Applied)
16 Purpose: Capture Image of the coronary sinus before and after stent deployment Ultrasound Machine has 2 probes but can only process information from one port at a time Probe attached to machine will be changed between deployment of stents Distal Stent Proximal Stent Figure 14: Locations of Ultrasonic Probes
17 Stent penetration Change in coronary sinus diameter
18 Component Material Estimated Number/Size Price Mechanical Components: Metal supports within chamber Aluminum $150 Chamber 1/4 inch Plexiglas 8 x 8 x 10 $175 Sheets Camera mounting device Aluminum $225 Piping for pumping mechanism $40 Oscillating pressure pump 1 Provided Consistent pressure pump 1 Provided Fisher Scientific water heater (model: 8001) Provided Thermometer Provided Pressure rod Provided Miscellaneous (bolts, screws, clips, clamps, $50 etc.) PTMA Testing Components: Porcine Heart(s) Multiple Provided Stent/Bridge constriction device 1 Provided Sheath 1 Provided Catheter 1 Provided Data Acquisition Equipment: PCI cameras 2 Provided Mindray Digital Ultrasonic Diagnostic Imaging 1 Provided System (model: DP-6900) FlexiForce Sensors 7-8 $200 Load Cells 5-6 Provided Computer LabVIEW Provided Hardware/Software: SolidWorks Provided MATLAB Provided Total Estimated Cost: $840 Total Spent: $217.38
19 Dr. Wei Sun Thuy Pham Dr. Enderle Sarah Daniel Ruscansky
20
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