TAVR for low-risk patients in 2017: not so fast.
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1 TAVR for low-risk patients in 2017: not so fast. Enrico Ferrari, MD, FETCS Cardiac Surgery Department Cardiocentro Ticino Foundation Lugano, Switzerland
2 Conflicts of Interest Consultant and proctor for Edwards Lifesciences (Irvine, CA, US) Consultant for Comed (Bolsward, The Netherlands) 2
3 TAVR Transcatheter Aortic Valve Replacement Balloon-expandable or self-expandable valves Indication: severe AS, failed bioprosthesis (VinV) Available accesses: TF, TA, TAO, trans-subclavian, trans-carotid EVOLVING TECHNOLOGY: repositionable/retrievable valves, lowprofile delivery systems, new valve design to prevent PVL 3
4 TAVR in 2017 Proven efficacy in inoperable and high-risk patients Proven efficacy in failed bioprosthesis (VinV) Incoming data are showing good results in moderate-risk patients Proven hemodynamics over the years WHY NOT PERFORMING TAVR IN LOW-RISK PATIENTS AS WELL? 4
5 Agenda 1. Vascular and access-site related complications 2. Paravalvular leak 3. PM implantation 3. Valve durability 5
6 1. Vascular and access-site related complications 2. Paravalvular leak 3. PM implantation 3. Valve durability 6
7 Preoperative vascular assessment 7
8 Vascular complications Never force the indication for TF 8
9 Vascular complications in TAVR Drop in access-site related major/life-threatening vascular complication rate with low-profile devices (32Fr 14Fr sheath) Vascular complications: 5-11% (dissection, rupture) (SAVR: <2%) TF >> TA = TAO New devices will further decrease the risk Choice of the right TAVR access-site is the key factor to further decrease vascular complications (Heart-Team) 1. Ferrari et al. Transfemoral versus transapical approach for transcatheter aortic valve implantation: hospital outcome and risk factor analysis. J Cardiothorac Surg Sep 6;12(1):78. doi: /s Wendler et al. SOURCE 3: 1-year outcomes post-transcatheter aortic valve implantation using the latest generation of the balloon-expandable transcatheter heart valve. Eur Heart J Jun 12. doi: /eurheartj/ehx Romano et al. Transaortic transcatheter aortic valve implantation using SAPIEN XT or SAPIEN 3 valves in the ROUTE registry. Interact Cardiovasc Thorac Surg Jun 5. doi: /icvts/ivx Ando et al. Comparison of In-Hospital Outcomes of Transcatheter Aortic Valve Implantation Versus Surgical Aortic Valve Replacement in Obese (Body Mass Index 30 Kg/M2) Patients. Am J Cardiol Aug 7. pii: S (17) Bapat et al. Transcatheter Aortic Valve Replacement Using Transaortic Access: Experience From the Multicenter, Multinational, Prospective ROUTE Registry. JACC Cardiovasc Interv Sep 12;9(17):
10 1. Vascular and access-site related complications 2. Paravalvular leak 3. PM implantation 3. Valve durability 10
11 PLV PVL ++ Re-ballooning PVL + 11
12 PVL and mortality 12
13 SAPIEN 3 13
14 SAPIEN 3 14
15 Repositionable valves LOTUS Valve (996pts) - repositioned: 29.2% - Severe PVL: 0% - Moderate PVL: 0.3% Evolut R (151pts, 317pts) - repositioned: 22.1% - Moderate to Severe PVL: 0-8% 1. Falk et al. Safety and efficacy of a repositionable and fully retrievable aortic valve used in routine clinical practice: the RESPOND Study. Eur Heart J Jun 22. doi: /eurheartj/ehx Schulz et al. Transcatheter aortic valve implantation with the new-generation Evolut R : Comparison with CoreValve in a single center cohort. Int J Cardiol Heart Vasc Jul 5;12: Noble et al. Comparison of procedural and clinical outcomes with Evolut R versus Medtronic CoreValve: a Swiss TAVI registry analysis. Eurointervention Apr 7;12(18):e2170-e
16 PVL after TAVR Moderate to severe PVL rate after TAVR: % (SAVR: 0-2%; sutureless valves: %) Moderate PVL > severe PVL New valve design to decrease the risk of PVL Balloon pre-dilation increases the risk of PVL (RR:0.59) No BAV, choice of the right TAVR-valve, Positioning, sizing, post-tavr re-ballooning and bailout VinV are key factors to further decrease the risk of PVL post-tavr 1. Falk et al. Safety and efficacy of a repositionable and fully retrievable aortic valve used in routine clinical practice: the RESPOND Study. Eur Heart J Jun 22. doi: /eurheartj/ehx Wendler et al. SOURCE 3: 1-year outcomes post-transcatheter aortic valve implantation using the latest generation of the balloon-expandable transcatheter heart valve. Eur Heart J Jun 12. doi: /eurheartj/ehx Waterbury et al. Techniques and outcomes of paravalvular leak repair after transcatheter aortic valve replacement. Catheter Cardiovasc Interv Aug 2. doi: /ccd Ferrari et al. Transfemoral versus transapical approach for transcatheter aortic valve implantation: hospital outcome and risk factor analysis. J Cardiothorac Surg Sep 6;12(1):78. doi: /s Kleczynski et al. Impact of post-dilatation on the reduction of paravalvular leak and mortality after transcatheter aortic valve implantation. Kardiol Pol. 2017;75(8): Möllmann et al. Implantation and 30-Day Follow-Up on All 4 Valve Sizes Within the Portico Transcatheter Aortic Bioprosthetic Family. JACC Cardiovasc Interv Aug 14;10(15): Auffrel et al. Feasibility, safety, and efficacy of transcatheter aortic valve replacement without balloon predilation: A systematic review and meta-analysis. Catheter Cardiovasc Interv Apr 12. doi: /ccd.27040
17 1. Vascular and access-site related complications 2. Paravalvular leak 3. PM implantation 3. Valve durability 17
18 PM after TAVR 18
19 Predictors for new PM after TAVR PRE PRE POST PRE 1. Siontis et al. Predictors of permanent pacemaker implantation in patients with severe aortic stenosis undergoing TAVR: a meta-analysis. J Am Coll Cardiol Jul 15;64(2):
20 Source Patients per each cohort Perceval PM (%) Traditional PM (%) P value Pollari. et al PM after TAVR Gilmanov et al Laborde et al na Meuris et al na New PM after TAVR: 6-30% (SAVR: %; sutureless valves: %) Lotus > CoreValve > Sapien Balloon pre-dilation seems not to increase the risk of PM Positioning, sizing, and choice of the right TAVR-valve, are key factors to decrease the risk of new PM implantation (less oversizing, better re-positioning: not-too-low ) 1. Noble et al. Comparison of procedural and clinical outcomes with Evolut R versus Medtronic CoreValve: a Swiss TAVI registry analysis. Eurointervention Apr 7;12(18):e2170-e Falk et al. Safety and efficacy of a repositionable and fully retrievable aortic valve used in routine clinical practice: the RESPOND Study. Eur Heart J Jun 22. doi: /eurheartj/ehx Möllmann et al. Implantation and 30-Day Follow-Up on All 4 Valve Sizes Within the Portico Transcatheter Aortic Bioprosthetic Family. JACC Cardiovasc Interv Aug 14;10(15): Ferrari et al. Transfemoral versus transapical approach for transcatheter aortic valve implantation: hospital outcome and risk factor analysis. J Cardiothorac Surg Sep 6;12(1):78. doi: /s Auffrel et al. Feasibility, safety, and efficacy of transcatheter aortic valve replacement without balloon predilation: A systematic review and meta-analysis. Catheter Cardiovasc Interv Apr 12. doi: /ccd Annular Valve Placement
21 1. Vascular and access-site related complications 2. Paravalvular leak 3. PM implantation 3. Valve durability 21
22 SAVR bioprosthesis FU > 20 years Proven age-related durability 22
23 SAVR bioprosthesis FU > 20 years Proven age-related durability 23
24 TAVR valve durability 5 year follow-up shows good results with low degeneration rate Limited number of survivors from first cohorts of patients. Long-term durability can be limited by: Underexpansion Crimping Calcium in native leaflets 1. Gerkens et al. Final 5-year clinical and echocardiographic results for treatment of severe aortic stenosis with a self-expanding bioprosthesis from the ADVANCE Study. Eur Heart J Jun 13. doi: /eurheartj/ehx Sondergaard. Time to Explore Transcatheter Aortic Valve Replacement in Younger, Low-Risk Patients. JACC Cardiovasc Interv Nov 14;9(21): Martin et al. Transcatheter Valve Underexpansion Limits Leaflet Durability: Implications for Valve-in-Valve Procedures. Ann Biomed Eng Feb;45(2): Abdelghani et al. Patient selection for TAVI in 2016: should we break through the low-risk barrier? EuroIntervention Sep 18;12(Y):Y Kovac et al. Four-year experience with the CoreValve transcatheter heart valve. EuroIntervention Oct 10;12(8):e1039-e
25 Discussion In TAVR, incidence of PVL, vascular complications and new PM implantation is still high compared to SAVR Long-term TAVR valve durability is still not yet proven Hospital mortality and stroke after TAVR are low and more related to the patients comorbidities than to the procedure itself Next generation TAVR devices will overcome the limits of the available valves. 25
26 Conclusion In 2017, TAVR has higher risks of PVL, vascular complications and new PM implantation compared to SAVR. While waiting for next-generation devices and long-term results, TAVR in low-risk patients should only be considered in selected cases. 26
27 Thank You
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