PCI for Chronic Total Occlusions

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1 PCI for Chronic Total Occlusions

2 Chronic Total Occlusions Why not Medical Treatment?

3 Medical Treatment CTO in 891 pts over 24 years High 10% Mortality Low 2 % 1 year 10 years Puma JA, et al. JACC 1994;23:390A

4 Chronic Total Occlusions 20-40% of patients with CAD Why should we open?

5 Effect on LV function PCI in CTO improves LV function (%) Pre 6 Mo Post *P < LV EDVI ESVI EF PCWP 57 Van Belle E, et al. AJC 1997;80:

6 Reopening of CTO Improves Survival 96 pts, EF<40% F/U 40 ± 17 mo * 40% *P < % Successful Failed PTCA 19% Mortality 8% CABG Schultze C, et al. Am J Cardiol 2002;90:148H

7 Survival Outcomes Successful vs Failed PTCA % Successful 5 year freedom from death, MI & CABG *P < % Failed PTCA Bell MR, et al. Circ 1992;85: Clin Investig 1994;72:442-7

8 Chronic Total Occlusion Rationale for Invasive Treatment To relieve symptom itself To improve LV function To impact late outcomes Improved mortality Freedom from subsequent CABG

9 What are the problems in reopening of CTO? Low Procedural Success High Clinical and Angiographic Restenosis

10 Procedural Success Predictors Duration of occlusion Length of occluded lesion Absence of antegrade flow Absence of stump Presence of bridging collateral

11 Procedural Success Favorable Unfavorable Tapered stump Stump absent Functional occlusion Total occlusion Pre or post occlusion Side branch(+) Bridging collateral (-) Bridging collateral (+)

12 Procedural Failure Multivariate analysis Variables Calcification Multivessel disease Lesion length >20mm Duration of occlusion P value < 0.01 < 0.01 < Odds ratio Nouguchi et al, Cathet. Cardiovasc. Intervent 2000;49:258-64

13 Failure of PCI in CTO Why? Crossing Failure of Guidewire

14 Reopening of CTO Conventional Guidewires New Generation Guidewires New Devices for crossing lesion FrontRunner TM Catheter OCR SafeSteer TM System (Optical Coherence Reflectometry)

15 Wiring in CTO Conventional Guidewire vs. New Generation

16 Conventional Wiring of CTO Success rate < 50% Age of occlusion is biggest determinant of failure

17 Ability to Cross CTO Hydrophilic-coated coated Guidewire 1 st GW success (%) Crossover (%) GW success after crossover (%) Total GW No. Procedure (min) Conventional (n=46) Crosswire (n=42) P <0.001 < Lefevre et al, Am J Cardiol 2000;85:1144-7

18 Ability to Cross CTO Laser Guidewire Procedural Success Coronary Perforation Restenosis at 18 weeks Improved Angina Status Death / MI / CABG % 1-21 % % 66% 0% Hamburger JN, et al. AJC 1997;80: Hamburger, et al. JACC 1997;30: Schofer et al. JACC 1997;30:

19 Guidewire in CTO PCI New generation guidewires are an effective in the treatment of CTO refractory to conventional guidewires.

20 New Devices for CTO Crossing Lesion FrontRunner TM Catheter OCR SafeSteer TM System (Optical Coherence Reflectometry)

21 FrontRunner Catheter Intraluminal MicroDissection Blunt controlled passage through occlusion Uses elastic properties of adventitia vs inelastic fibrocalcific plaque

22 FrontRunner Catheter Advantages Torqueable Guide support Directable/Steerable Hydrophilic coating Blunt tip to avoid perforation Avoids side branches Disadvantages Difficult anatomy: tortuosity, small vessel, heavy calcium Expensive 8 Fr guiding for curved jaw Failure Modes

23 FrontRunner Technique 6 or 8 Fr guiding catheter Collateral visualization Tip shapeable and steerable Engagement in CTO & Jaw opening Torque and advance / retract Intraluminal vs subintimal Replace with guidewire Dilate and stent

24 FrontRunner Catheter Clinical Experiences 107 patients (mean 62 years) Refractory to guidewire Mean lesion length 21 ± 8 mm Overall Success 60 % Complication Rate 5 % Mehttew Selmon et al, ACC 2002

25 OCR SafeSteer System New Devices for CTO Forward looking guidance system, using OCR to determine tissue types (plaque vs arterial wall). Designed to navigate through total occlusion.

26 OCR SafeSteer System OCR Wavefore Displays

27 OCR SafeSteer System

28 OCR SafeSteer System Clinical Experiences Age (years) Male Occlusion length Occlusion age Success crossing Safe-Cross (n=13) % 40.2 mm 3.4 years 11 (85 %) Conventional wire (n=13) % 12 mm 5 years 8 (62 %) Heuser RR et al, TCT 2002

29 New Devices FrontRunner TM Catheter OCR SafeSteer TM System may be advantages for specific CTO refractory to conventional system.

30 To Achieve and Sustain Patency in CTO How? Stent vs PTCA Debulking

31 Stent vs PTCA Stent (n=48) PTCA(n=48) 42% 71% *P < 0.05 STOP Restenosis 7.9% 16% Reocclusion Lotan et al. Eur Heart J 2000;21:1960-6

32 Stent vs PTCA Stent (n=202) PTCA(n=208) 15% *P < % 16% TOSCA 23% 8.4% 11% TVR Restenosis MACE Buller et al. Circulation 1999;100:236-42

33 Stent vs PTCA Stent (n=58) PTCA(n=59) 59% *P < % SICCO 73% 24% 24% 32% MACE TLR Restenosis Sirnes et al. JACC 1998;32:

34 STENT in CTO improve reocclusion and restenosis rates over PTCA results.

35 Late Clinical and Angiographic Outcomes after Stenting in CTO AMC experience

36 Successful Recanalization of CTO Procedural success 241/324 (74%)

37 Risk Factors Current smoker Diabetes mellitus Hypercholesterolmia (> 200 mg/dl) Systemic hypertension Previous MI Stent length < 20mm (n=113) 50(44.2%) 19 (16.8%) 41 (32.3%) 52 (46.0%) 15 (13.3%) Stent length 20mm (n=107) 55(51.4%) 22 (20.6%) 45 (42.1%) 47 (43.9%) 10 (9.3%)

38 Angiographic Characteristics Lesion length (mm) Stent length (mm) Balloon to artery ratio Reference vessel size (mm) * p<0.05 Stent length < 20mm (n=113) 14.4± ± ± ±0.47 Stent length 20mm (n=107) 24.8±10.1* 29.4±5.9 * 1.13± ±0.48

39 Angiographic Characteristics Postintervention MLD Follow-up MLD Acute gain Late loss Loss index MLD: minimal lumen diameter Stent length < 20mm (n=113) 3.09± ± ± ± ±0.27 Stent length 20mm (n=107) 3.03± ± ± ± ±0.27

40 Angiographic Restenosis Overall restenosis: 26.4% *P < % Stent length < 20mm 33.7% Stent length 20mm

41 Major Cardiac Events Death, MI, TLR F/U 29.1±10.8 Months % Stent length < 20mm P =NS 14.4% Stent length 20mm

42 Predictors of Restenois Multivariate analysis Postprocedural minimal lumen diameter OR=0.20, 95% CI , p<0.01

43 Angiographic Restenosis According to MLD Post-procedure MLD < 3.0 mm Post-procedure MLD 3.0 mm 42% *P < % 29% Total 16% 12% Stent length < 20mm 19% Stent length 20mm

44 Debulking Strategy Additive effect over stent alone? Controversial

45 Debulking with Stent Debulking with Excimer Laser, Directional or Rotational Atherectomy Success (%) Final MLD (%) In-Hosp. MACE (%) MACE at FU (%) TLR (%) Debulking + S (n = 50) Stent alone (n = 126) P NS NS NS NS NS Gruberg L et al. JACC 2000;35:151-6

46 Debulking with Stent Rotational Atherectomy RA+Stent (n=202) Stent only (n=208) * P< % 2.7 mm mm % Post-MLD FU-MLD Restenosis Tsuchikane E, et al. J Invasive Cardiol 2001;13:584-9

47 PCI for Chronic Total Occlusions Future perspective drug eluting stent?

48 SIRIUS - QCA Peri-Stent Analysis Silorimus (n=349) Control (n=353) P< % 91% % % P=0.285 P= Proximal margin In-stent 2.0 Distal margin

49 Drug-Eluting Stents Ostial lesions no data Bifurcations need more data In-stent restenosis need more data SVGs no data Small vessels need more data Diffuse disease need more data Left main disease no data Total occlusions no data

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