TITLE: Positron Emission Tomography in Neurology and Cardiology: A Review of Guidelines and Recommendations
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1 TITLE: Positron Emission Tomography in Neurology and Cardiology: A Review of Guidelines and Recommendations DATE: 27 January 2014 CONTEXT AND POLICY ISSUES Positron emission tomography (PET) imaging, since the introduction of the concept of emission and transmission tomography in 1950, has been a major part of nuclear medicine and has proved to be a valuable non-invasive tool in the diagnosis and management of various disorders in many fields, from clinical oncology to neurology, from musculo-skeletal imaging to cardiology. 1,2 PET has been used with success for the evaluation of neurological disorders such as cognitive function in Alzheimer s disease and diagnosis of brain tumours. 3-5 PET also has shown its significant roles in the detection and prognosis of various cardiac disorders such as coronary artery disease (CAD), cardiac sarcoidosis, as well as in the assessment of myocardial perfusion and viability This Rapid Response report aims to review the guidelines and recommendations associated with the use of PET in neurology and cardiology. RESEARCH QUESTIONS 1. What are the evidence-based guidelines regarding the use of positron emission tomography in neurology? 2. What are the evidence-based guidelines regarding the use of positron emission tomography in cardiology? KEY FINDINGS The literature search identified a limited number of guidelines on the use of PET in neurology and cardiology. PET is not recommended for the diagnosis or grading of gliomas, and is recommended in typical cases of dementia and cranial neuropathy where diagnosis remains in Disclaimer: The Rapid Response Service is an information service for those involved in planning and providing health care in Canada. Rapid responses are based on a limited literature search and are not comprehensive, systematic reviews. The intent is to provide a list of sources of the best evidence on the topic that CADTH could identify using all reasonable efforts within the time allowed. Rapid responses should be considered along with other types of information and health care considerations. The information included in this response is not intended to replace professional medical advice, nor should it be construed as a recommendation for or against the use of a particular health technology. Readers are also cautioned that a lack of good quality evidence does not necessarily mean a lack of effectiveness particularly in the case of new and emerging health technologies, for which little information can be found, but which may in future prove to be effective. While CADTH has taken care in the preparation of the report to ensure that its contents are accurate, complete and up to date, CADTH does not make any guarantee to that effect. CADTH is not liable for any loss or damages resulting from use of the information in the report. Copyright: This report contains CADTH copyright material and may contain material in which a third party owns copyright. This report may be used for the purposes of research or private study only. It may not be copied, posted on a web site, redistributed by or stored on an electronic system without the prior written permission of CADTH or applicable copyright owner. Links: This report may contain links to other information available on the websites of third parties on the Internet. CADTH does not have control over the content of such sites. Use of third party sites is governed by the owners own terms and conditions.
2 doubt after magnetic resonance imaging (MRI) is equivocal or cannot be performed. The use of PET is reasonable to determine the presence of CAD in patients with hypertrophic cardiomyopathy (HCM) with chest discomfort and in patients with acute or chronic heart failure. METHODS Literature Search Strategy A limited literature search was conducted on key resources including PubMed, The Cochrane Library (2013, Issue 12), University of York Centre for Reviews and Dissemination (CRD) databases, ECRI (Health Devices Gold), Canadian and major international health technology agencies, as well as a focused Internet search. Methodological filters were applied to limit retrieval to health technology assessments, systematic reviews, meta-analyses and guidelines. Where possible, retrieval was limited to the human population. The search was also limited to English language documents published between January 1, 2009 and December 18, Selection Criteria and Methods One reviewer screened the titles and abstracts of the retrieved publications and evaluated the full-text publications for the final article selection, according to selection criteria presented in Table 1. Table 1: Selection Criteria Population Patients referred to PET scanning for cardiology (e.g. coronary artery disease, myocardial viability, ischemia viability, ventricular function) or neurology indications (e.g. Alzheimer s disease, Parkinson s, epilepsy, brain tumours, dementia) Intervention Positron emission tomography Comparator None Outcomes Guidelines and recommendations (diagnosis and management) - Patient indications Study Designs Guidelines Exclusion Criteria Articles were excluded if they did not meet the selection criteria in Table 1, if they were published prior to January 2009, or if they were duplicate publications of the same study. Critical Appraisal of Individual Studies The quality of the included guidelines was assessed using AGREE checklist. 12 Numeric scores were not calculated. Instead, the strengths and limitations of the guidelines are summarized and presented. PET in neurology and cardiology 2
3 SUMMARY OF EVIDENCE Quantity of Research Available The literature search yielded 352 citations. After screening of abstracts from the literature search and from other sources, 52 potentially relevant studies were selected for full-text review. Five studies were included in the review. The PRISMA flowchart in Appendix 1 details the process of the study selection. Summary of Critical Appraisal The included guidelines had specific and unambiguous recommendations, with systematic and clearly described methods of searching for and selecting the evidence, and for formulating the recommendations. Health benefits and risks were stated, and procedures to update the guidelines were provided. It is unclear whether the guidelines were piloted among target users and whether patients view and preferences were sought. Potential cost implications of applying the recommendations were not included. Recommendations from Cancer Care Ontario on PET imaging on gliomas did not report strength of evidence. 13 Details of the strengths and limitations of the included studies are summarized in Appendix 2. Summary of Findings Main findings of included guidelines are summarized in detail in Appendix 3. Definitions of different levels of confidence and different classes of recommendations used in the included guidelines are in Appendix What are the evidence-based guidelines regarding the use of positron emission tomography in neurology? Recommendations from Cancer Care Ontario 13 stated that PET is not recommended for the determination of diagnosis or grading in gliomas, and that a recommendation cannot be made for or against the use of PET for the assessment of treatment response or in the assessment of patients with recurrent gliomas due to insufficient evidence. Guidelines from the Agency for Healthcare Research and Quality (AHRQ) 14 recommended that although typical cases of dementia may not benefit from routine PET imaging, PET is recommended in cases where diagnosis remains in doubt after MRI work-up and in particular clinical settings. In cases where dementia is suspected, normal findings from FDG-PET scan (fluorine-18 ( 18 F)-2-fluoro-2-deoxy-D-glucose-PET) make a neurodegenerative diagnosis less likely. These recommendations are classified as Class II (conflicting evidence and/or a divergence of opinion about the usefulness/efficacy of the given treatment or procedure) and with level A of confidence (data derived from multiple randomized clinical trials or metaanalyses). Guidelines from the Agency for Healthcare Research and Quality (AHRQ) 15 recommended that whole body FDG-PET/CT (computed tomography) is useful for the diagnosis of cranial neuropathy when MRI is equivocal or cannot be performed, especially in patients with PET in neurology and cardiology 3
4 suspected or proven neoplastic process. The guidelines gave the recommendations a Rating Scale of 1 (the use of the procedure usually not appropriate). 2. What are the evidence-based guidelines regarding the use of positron emission tomography in cardiology? Guidelines from the Agency for Healthcare Research and Quality (AHRQ) 16 recommended that the use of PET or SPECT (single photon emission computed tomography) is useful to assess ischemia or perfusion abnormalities suggestive of CAD. The use of PET or SPECT is reasonable to rule out CAD in patients with HCM with chest discomfort. The recommendation is classified as Class IIa (benefit outweighs risk; weight of evidence/opinion is in favour of usefulness/efficacy.) and with level C of confidence (data from consensus of opinion of the experts and/or small studies, retrospective studies, registries). PET is not indicated for the assessment of the presence of blunted flow reserve (microvascular ischemia) in the prognosis in patients with HCM. This recommendation is classified as Class III (no benefit) with level C of confidence (data from consensus of opinion of the experts and/or small studies, retrospective studies, registries). Guidelines from the Agency for Healthcare Research and Quality (AHRQ) 17 recommended that PET or other myocardial perfusion/ischemia techniques (such as SPECT, echocardiography) should be considered in patients with acute or chronic heart failure who may have CAD. The recommendation is classified as Class IIa (benefit >> risk; weight of evidence/opinion is in favour of usefulness/efficacy) and with level C of confidence (data from consensus of opinion of the experts and/or small studies, retrospective studies, registries). Limitations Guidelines on the use of PET in neurology and cardiology were limited to a number of clinical disorders (gliomas, dementia, cranial neuropathy, CAD in hypertrophic cardiomyopathy and heart failure). Guidelines and recommendations on the use of PET on other neurological and cardiac disorders are needed. CONCLUSIONS AND IMPLICATIONS FOR DECISION OR POLICY MAKING The literature search identified a limited number of guidelines on the use of PET in neurology and cardiology. PET is not recommended for the diagnosis or grading of gliomas, and is recommended in typical cases of dementia and cranial neuropathy where diagnosis remains in doubt after MRI is equivocal or cannot be performed. The use of PET is reasonable to determine the presence of CAD in patients with HCM with chest discomfort and in patients with acute or chronic heart failure. Advancements in the field of nuclear medicine in the development of hybrid systems that combine PET with CT and MRI may further increase the indications of PET in clinical use. The hybrid systems may increase sensitivity, reduce radiation dose, decrease scanning time, and reduce motion artifact, and have been shown to be useful in diverse oncological, cardiac and neurological applications Further investigations are needed to increase the performances of non-invasive imaging techniques. Appropriate use of PET is recommended to increase its diagnostic value and its cost-effectiveness. PET in neurology and cardiology 4
5 PREPARED BY: Canadian Agency for Drugs and Technologies in Health Tel: PET in neurology and cardiology 5
6 REFERENCES 1. Portnow LH, Vaillancourt DE, Okun MS. The history of cerebral PET scanning: from physiology to cutting-edge technology. Neurology Mar 5;80(10): Bailey DL, Townsend DW, Valk PE, Maisey MN. Positron emission tomography: basic sciences. Secaucus (NJ): Springer-Verlag; Bloudek LM, Spackman DE, Blankenburg M, Sullivan SD. Review and meta-analysis of biomarkers and diagnostic imaging in Alzheimer's disease. J Alzheimers Dis. 2011;26(4): Beta amyloid imaging with positron emission tomography (PET) for evaluation of suspected Alzheimer's disease or other causes of cognitive decline. Technol Eval Cent Assess Program Exec Summ Feb;27(5): Dunet V, Prior JO. Diagnostic accuracy of F-18-fluoroethyltyrosine PET and PET/CT in patients with brain tumor. Clin Transl Imaging. 2013;1(2): Dowsley T, Al-Mallah M, Ananthasubramaniam K, Dwivedi G, McArdle B, Chow BJ. The role of noninvasive imaging in coronary artery disease detection, prognosis, and clinical decision making. Can J Cardiol Mar;29(3): Jaarsma C, Leiner T, Bekkers SC, Crijns HJ, Wildberger JE, Nagel E, et al. Diagnostic performance of noninvasive myocardial perfusion imaging using single-photon emission computed tomography, cardiac magnetic resonance, and positron emission tomography imaging for the detection of obstructive coronary artery disease: a meta-analysis. J Am Coll Cardiol May 8;59(19): Al Moudi M, Sun Z, Lenzo N. Diagnostic value of SPECT, PET and PET/CT in the diagnosis of coronary artery disease: a systematic review. Biomed Imaging Interv J [Internet] Apr [cited 2013 Dec 20];7(2):e9. Available from: 9. Youssef G, Leung E, Mylonas I, Nery P, Williams K, Wisenberg G, et al. The use of 18F- FDG PET in the diagnosis of cardiac sarcoidosis: a systematic review and metaanalysis including the Ontario experience. J Nucl Med [Internet] Feb [cited 2013 Dec 23];53(2): Available from: Allman KC. Noninvasive assessment myocardial viability: current status and future directions. J Nucl Cardiol Aug;20(4): Medical Advisory Secretariat. Non-invasive cardiac imaging technologies for the assessment of myocardial viability: a summary of evidence-based analyses. Ont Health Technol Assess Ser [Internet] Jul [cited 2014 Jan 14];10(14):1-24. Available from: lity_aggregate_ pdf PET in neurology and cardiology 6
7 12. The AGREE Collaboration. Appraisal of guidelines for research and evaluation (AGREE) instrument [Internet]. London: The AGREE Research Trust; 2001 Sep. [cited 2014 Jan 24]. Available from: Laperriere N, Walker-Dilks C. PET imaging in brain cancer [Internet]. Toronto: Cancer Care Ontario; 2009 Jan 29. [cited 2014 Jan 14]. (PET recommendation report 10 in review). Available from: Filippi M, Agosta F, Barkhof F, Dubois B, Fox NC, Frisoni GB, et al. EFNS task force: the use of neuroimaging in the diagnosis of dementia. Eur J Neurol Dec;19(12):e131- e National Guideline Clearinghouse [Internet]. Rockville (MD): Agency for Healthcare Research and Quality (AHRQ); [1997] -. Guideline summary: ACR appropriateness criteria cranial neuropathy; 2012 [cited 2014 Jan 14]. Available from: Gersh BJ, Maron BJ, Bonow RO, Dearani JA, Fifer MA, Link MS, et al ACCF/AHA guideline for the diagnosis and treatment of hypertrophic cardiomyopathy. J Am Coll Cardiol [Internet] Dec 13 [cited 2014 Jan 14];58(25):e212-e260. Available from: McMurray JJ, Adamopoulos S, Anker SD, Auricchio A, Bohm M, Dickstein K, et al. ESC guidelines for the diagnosis and treatment of acute and chronic heart failure Eur Heart J [Internet] Jul [cited 2014 Jan 14];33(14): Available from: Positron emission tomography (PET) and PET/CT fusion [Internet]. Indianapolis (IN): Anthem; [cited 2014 Jan 14]. (Medical policy). Available from: Flotats A, Knuuti J, Gutberlet M, Marcassa C, Bengel FM, Kaufmann PA, et al. Hybrid cardiac imaging: SPECT/CT and PET/CT. Eur J Nucl Med Mol Imaging Jan [cited 2013 Dec 20];38(1): Available from: y.pdf?auth66= _ c171e63a7e3e528a70670c16d&ext=.pdf 20. Dorbala S, Di Carli MF, Delbeke D, Abbara S, DePuey EG, Dilsizian V, et al. SNMMI/ASNC/SCCT guideline for cardiac SPECT/CT and PET/CT 1.0. J Nucl Med [Internet] Aug [cited 2013 Dec 20];54(8): Available from: The Royal College of Physicians and the Royal College of Radiologists. Evidence-based indications for the use of PET-CT in the UK 2013 [Internet]. London: RCP, RCR; [cited 2014 Jan 16]. Available from: PET in neurology and cardiology 7
8 Appendix 1: Selection of Included Studies 352 citations identified from electronic literature search and screened 313 citations excluded 39 potentially relevant articles retrieved for scrutiny (full text, if available) 13 relevant reports retrieved from other sources (grey literature, hand search) 52 potentially relevant reports 47 reports excluded (irrelevant design, populations, interventions or outcomes) 5 reports included in review PET in neurology and cardiology 8
9 Appendix 2: Summary of Critical Appraisal of Included Studies Table A1: Summary of Critical Appraisal of Included Study First Author, Publication Year Strengths Limitations Critical appraisal of included guidelines and recommendations(agree 12 ) Cancer Care Ontario, scope and purpose of the guidelines are clear the recommendations are specific and unambiguous the method for searching for and selecting the evidence are clear methods used for formulating the recommendations are clearly described health benefits, side effects and risks were stated in the recommendations procedure for updating the guidelines provided target users of the guideline are clearly defined AHRQ, scope and purpose of the guidelines are clear the recommendations are specific and unambiguous the method for searching for and selecting the evidence are clear methods used for formulating the recommendations are clearly described health benefits, side effects and risks were stated in the recommendations procedure for updating the guidelines provided target users of the guideline are clearly defined AHRQ, scope and purpose of the guidelines are clear the recommendations are specific and unambiguous the method for searching for and selecting the evidence are clear methods used for formulating the recommendations are clearly described health benefits, side effects and risks were stated in the recommendations procedure for updating the guidelines provided target users of the guideline are clearly defined AHRQ, scope and purpose of the guidelines are clear the recommendations are specific and unambiguous the method for searching for and selecting the evidence are clear methods used for formulating the unclear whether the guideline was piloted among target users unclear whether patients views and preferences were sought potential cost implications of applying the recommendation not included strength of evidence not reported unclear whether the guideline was piloted among target users unclear whether patients views and preferences were sought potential cost implications of applying the recommendation not included unclear whether the guideline was piloted among target users unclear whether patients views and preferences were sought potential cost implications of applying the recommendation not included strength of evidence not reported unclear whether the guideline was piloted among target users unclear whether patients views and preferences were sought potential cost implications of applying the recommendation not included PET in neurology and cardiology 9
10 Table A1: Summary of Critical Appraisal of Included Study First Author, Strengths Publication Year recommendations are clearly described health benefits, side effects and risks were stated in the recommendations procedure for updating the guidelines provided target users of the guideline are clearly defined AHRQ, scope and purpose of the guidelines are clear the recommendations are specific and unambiguous the method for searching for and selecting the evidence are clear methods used for formulating the recommendations are clearly described health benefits, side effects and risks were stated in the recommendations procedure for updating the guidelines provided target users of the guideline are clearly defined AHRQ: Agency for Healthcare Research and Quality Limitations unclear whether the guideline was piloted among target users unclear whether patients views and preferences were sought potential cost implications of applying the recommendation not included PET in neurology and cardiology 10
11 Appendix 3: Main Study Findings and Authors Conclusions Table A2: Main Study Findings and Authors Conclusions First Author, Main Study Findings Publication Year Research question 1 (evidence-based guidelines regarding the use of positron emission tomography in neurology) Cancer Care Clinical condition: gliomas Ontario, 13 Diagnosis/Staging 2009 PET is not recommended for the determination of diagnosis or grading in gliomas. Assessment of Treatment Response A recommendation cannot be made for or against the use of PET for the assessment of treatment response in gliomas due to insufficient evidence. AHRQ, AHRQ, Recurrence/Restaging A recommendation cannot be made for or against the use of PET or PET/CT in the assessment of patients with recurrent gliomas due to insufficient evidence. (p 4, 5) Clinical condition: dementia 1. Although typical cases of dementia may not benefit from routine single positron emission computed tomography (SPECT) or positron emission tomography (PET) imaging, these tools are recommended in those cases where diagnosis remains in doubt after clinical and structural MRI work-up and in particular clinical settings (Class II, Level A). 2. Functional imaging can be of value to diagnose (or exclude) a neurodegenerative dementia in those subjects with cognitive impairment presenting with severe psychiatric disturbances (including depression and agitation) and in cases where proper cognitive testing is difficult, that is, with no language in common with the clinician (Good Practice Point). 3. Normal fluorine-18 ( 18 F)-2-fluoro-2-deoxy-D-glucose (FDG) PET scan findings, in the presence of the suspicion of dementia, make a neurodegenerative diagnosis less likely (Class II, Level A). (p 5) Clinical Condition: Cranial Neuropathy Variant 1: Anosmia and abnormalities of the sense of smell. in patients with suspected or proven neoplastic process. (rating scale 1) (p 5) Variant 2: Weakness or paralysis of the muscles of mastication; sensory abnormalities of the head and neck. in patients with suspected or proven neoplastic process. (rating scale 1) (p 6) Variant 3: Weakness or paralysis of facial expression. in patients with suspected or proven neoplastic process. (rating scale 1) (p 7) Variant 4: Palate weakness. in patients with suspected or proven neoplastic process. (rating scale 1) (p 9) Variant 5: Vocal cord paralysis. in patients with suspected or proven neoplastic process. (rating scale 1) (p 10) Variant 6: Weakness or paralysis of the sternocleidomastoid and trapezius muscles. in patients with suspected or proven neoplastic process. (rating scale 1) (p 11) PET in neurology and cardiology 11
12 Table A2: Main Study Findings and Authors Conclusions First Author, Publication Year Main Study Findings Variant 7: Weakness or paralysis of the tongue. in patients with suspected or proven neoplastic process. (rating scale 1) (p 12) Variant 8: Perineural spread of tumor. in patients with suspected or proven neoplastic process. (rating scale 1) (p 13) Research question 2 (evidence-based guidelines regarding the use of positron emission tomography in cardiology) AHRQ, Clinical condition: Concomitant Coronary Disease in hypertrophic cardiomyopathy AHRQ, Class IIa (Benefit >> Risk; Additional studies with focused objectives needed) Assessment of ischemia or perfusion abnormalities suggestive of CAD with single photon emission computed tomography (SPECT) or positron emission tomography (PET) myocardial perfusion imaging (MPI; because of excellent negative predictive value) is reasonable in patients with HCM with chest discomfort and a low likelihood of CAD to rule out possible concomitant CAD. (Level of Evidence: C) (p 9) Class III (no benefit) Assessment for the presence of blunted flow reserve (microvascular ischemia) using quantitative myocardial blood flow measurements by PET is not indicated for the assessment of prognosis in patients with HCM. (Level of Evidence: C) (p 9) Clinical condition: heart failure Myocardial perfusion/ischaemia imaging (echocardiography, CMR, single-photon emission computed tomography [SPECT], or positron emission tomography [PET]) should be considered in patients thought to have coronary artery disease (CAD), and who are considered suitable for coronary revascularization, to determine whether there is reversible myocardial ischaemia and viable myocardium. (Class of recommendation IIa, level of evidence C) (p 6) AHRQ: Agency for Healthcare Research and Quality; CT: computed tomography; FDG-PET: fluorine-18 ( 18 F)-2-fluoro- 2-deoxy-D-glucose (FDG) - Positron Emission Tomography scan PET in neurology and cardiology 12
13 Appendix 4: Summary of definitions of level of confidence and classes of recommendations used in included guidelines 17 Levels of Evidence Level of Evidence A Level of Evidence B Level of Evidence C Data derived from multiple randomized clinical trials or meta-analyses. Data derived from a single randomized clinical trial or large non-randomized studies. Consensus of opinion of the experts and/or small studies, retrospective studies, registries. Classes of Recommendations Classes of Recommendations Definition Suggested Wording to Use Class I Evidence and/or general agreement that a given treatment or procedure is beneficial, useful, effective. Is recommended/ is indicated Class II Conflicting evidence and/or a divergence of opinion about the usefulness/efficacy of the given treatment or procedure. Class IIa Weight of evidence/opinion is in favour of usefulness/efficacy. Should be considered Class IIb Usefulness/efficacy is less well established by evidence/opinion. May be considered Class III Evidence or general agreement that the given treatment or procedure Is not recommended is not useful/effective, and in some cases may be harmful. PET in neurology and cardiology 13
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