Repositioning of the Mineralocorticoid Receptor Antagonists in renal diseases: pathophysiological basis and therapeutic issues
|
|
|
- Ada Greene
- 6 years ago
- Views:
Transcription
1 # 3 Frédéric Jaisser 1 MD, PhD Professor in Physiology, INSERM Head of the Department Integrative Physiology and Pathophysiology, Cordeliers Research Center, Paris, France
2 Repositioning of the Mineralocorticoid Receptor Antagonists in renal diseases: pathophysiological basis and therapeutic issues Frédéric JAISSER INSERM U 1138 Centre de Recherche des Cordeliers Paris
3 Emerging roles of in several diseases HEART: heart failure myocardial infarction arrhythmia fibrosis ADIPOSE TISSUE: obesity KIDNEY: hypertension ischemic insult glomerular injury IMMUNE CELLS: inflammation RETINA: retinal edema neoangiogenesis central serous chorioretinitis BLOOD VESSELS: vasoconstriction endothelial dysfunction hypertension atherosclerosis remodelling SKIN: epidermal atrophy Jaisser and Farman. Pharmacol Rev 68:49, 2016
4 Emerging roles of in several diseases HEART: heart failure myocardial infarction arrhythmia fibrosis Therapeutic target: MR antagonists Spironolactone,eplerenone, finerenone ADIPOSE TISSUE: obesity KIDNEY: hypertension ischemic insult glomerular injury IMMUNE CELLS: inflammation RETINA: retinal edema neoangiogenesis central serous chorioretinitis BLOOD VESSELS: vasoconstriction endothelial dysfunction hypertension atherosclerosis remodelling SKIN: epidermal atrophy MR antagonist repurposing from Hypertension to.. Jaisser and Farman. Pharmacol Rev 68:49, 2016
5 Mineralocorticoid receptor expression in the kidney mesangial cells Glomeru lar capillari es podocyt es ve sse ls A S D N
6 New paradigm in and renal diseases
7 New paradigm in and renal diseases
8 New paradigm in and renal diseases?
9 Clinical trials with benefit of MR antagonists in renal diseases Ma and Szeto. Renal Failure 2012
10 Ongoing clinical trials on MRAs in renal diseases CHRONIC KIDNEY DISEASE NCT Mineralocorticoid Receptor Antagonists (spironolactone) in End Stage Renal Disease (MiREnDa) Wuerzburg University Hospital NCT A Study of LY in Male and Females With Chronic Kidney Disease Eli Lilly and Company NCT Effects of Spironolactone Combination Therapy on Proteinuria, Kidney Function, and Blood Pressure NCT Mineralocorticoid Antagonism (Spironolactone) and Endothelial Dysfunction in Autosomal Dominant Polycystic Kidney Disease (ADPKD) University of Colorado, Denver NCT Inhibition of Aldosterone (Eplerenone) in Patients With Chronic Renal Disease, Rigshospitalet, Denmark ESRD NCT L-Arginine and Spironolactone Trial in Dialysis-Dependent ESRD (LAST-D) Brigham and Women's Hospital NCT ALdosterone Antagonist (spironolactone) Chronic HEModialysis Interventional Survival Trial (ALCHEMIST) University Hospital, Brest NCT Effects of Spironolactone on Cardio- and Cerebrovascular Morbidity and Mortality in Hemodialysis Patients Dialysis Outcomes Heart Failure Aldactone Study Group NCT Eplerenone in Hemodialysis Trial (PHASE) McMaster University DIABETIC NEPHROPATHY NCT a study to evaluate the safety and tolerability of PF in patients with type 2 diabetic nephropathy Pfizer NCT Improving Outcomes in Patients With Kidney Disease Due to Diabetes (Spironolactone)National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) NCT RLY5016 in the Treatment of Hyperkalemia in Patients With Hypertension and Diabetic Nephropathy (AMETHYST-DN) Spironolactone NCT Safety and Efficacy of Different Oral Doses of Finerenone in Subjects With Type 2 Diabetes Mellitus and the Clinical Diagnosis of Diabetic Nephropathy (ARTS-DN) Bayer TRANSPLANTATION NCT Mineralocorticoid Receptor Antagonist (Spironolactone) and Kidney Allograft Histology Clinical Hospital Merkur NCT The Effects of Spironolactone on Calcineurin Inhibitor Induced Nephrotoxicity (SPIREN) Odense UniversityHospital NCT EPLErenone in CsA-Treated Recipients (EpleCsAT): Safety, Reims, France
11 New paradigm in and renal diseases Clinical implications and Pathophysiological mechanisms Bertocchio, Warnock, Jaisser. Kidney Int, 2011 Warnock,, Jaisser. Nature Nephrology Review, 2014
12 , microvasculature and organ damage KIDNEY Renal Blood flow: 800 ml/mn/100 g tissue HEART Coronary blood flow :3 ml/mn/100 g tissue EYE Retina blood flow : 125 ml/min/100 g tissue Choroid Blood Flow: ml/min/100 g tissue Collaboration: T. Hauet, INSERM U Poitiers P. Rieu, Nephro Unit Reims Collaboration: A. Ouvrard, P. Mulder, V. Richard INSERM U1096, Rouen Collaboration: F Behar-Cohen, U872 Team 17/Lausanne
13 Vascular MR and renal hemodynamics: implication in renal injury Ischemia/reperfusion injury warm ischemia: surgery cold ischemia: renal graft Ciclosporine (immunosupressor) nephrotoxicity acute/chronic vasculopathy Beneficial effects of pharmacological MR antagonism in rodents Hypothesis: Bobadilla, Mexico these renal injuries are associated to in the renal microvasculature
14 Working hypothesis Pharmacological or Vascular MR inactivation Vascular MR activation Oxidative stress inflammation Tubular lesions Renal damage
15 Mineralocorticoid Receptor Antagonists: from one to third generation Finerenone From J. Bauersachs. Eur Heart J, 2013
16 Vascular MR and renal hemodynamics: implication in renal injury Beneficial effects of pharmacological MR antagonism in renal ischemia/reperfusion injury Efficacy of a third-generation MR antagonist (BR4628) Barrera-Chimal J et al. J Am Soc Nephrol, In press
17 inactivates the Endothelin-B Receptor via a Cysteinyl Thiol Redox Switch to decrease endothelial NO levels Normal Ischemia ET-1 ET-1 ETB ETB Cys-S-OH p-s1177- enos ROS NO endothelium p-s1177- enos NO Smooth muscle Barrera-Chimal J et al. J Am Soc Nephrol, In press
18 inactivates the Endothelin-B Receptor via a Cysteinyl Thiol Redox Switch to decrease endothelial NO levels Normal Ischemia ET-1 ET-1 ETB ETB Cys-S-OH p-s1177- enos ROS NO endothelium p-s1177- enos NO Smooth muscle MR antagonists Barrera-Chimal J et al. J Am Soc Nephrol, In press
19 Vascular MR and renal hemodynamics: implication in renal injury Beneficial effects of pharmacological MR antagonism Clinical studies transplantation in RENAL ISCHEMIA/REPERFUSION limit Delayed Graft Function in renal from limit donors F Jaisser (CIC Nancy PI), S. Girerd (co-pi, CHU Nancy) L. Frimat (Nancy), P. Rieu (Reims), B. Moulin, (Strasbourg), D. Ducloux (Besancon) C. Mousson (Dijon), P. Grimbert (Créteil)
20 New paradigm in and renal diseases Clinical implications and Pathophysiological mechanisms Bertocchio, Warnock, Jaisser. Kidney Int, 2011 Warnock,, Jaisser. Nature Nephrology Review, 2014
21 Patho-physiological role of MR in diseases? Pharmacological MR antagonism: indications of old compounds PERSPECTIVES repositioning and novel HYPOTHESIS MR : «modifier» gene Aldo/MR molecular targets Phenotypes Aldosterone Animal model Human diseases - hypertension - heart failure - arrhythmia - metabolic diseases - kidney diseases
22 Patho-physiological role of MR in diseases? Pharmacological MR antagonism: indications of old compounds PERSPECTIVES repositioning and novel HYPOTHESIS MR : «modifier» gene Aldo/MR molecular targets Phenotypes Aldosterone Pet diseases -hypertension - heart failure - metabolic diseases - kidney diseases -??? Human diseases - hypertension - heart failure - arrhythmia - metabolic diseases - kidney diseases
23 # 3 23 Repositioning of the MRA in renal diseases: pathophysiological basis and therapeutic issues 1- Broad expression of the Mineralocorticoid Receptor beyond the classical targets Kidney (vessels, podocyte, ) Cardiovascular system Adipose tissue Inflammatory cells 2- Impact on kidney diseases Direct: glomerulopathies, inflammation, fibrosis Indirect: cardiovascular diseases (vascular, heart failure), metabolic 3- Benefit of MR antagonists in renal diseases Repositioning of available MR antagonists (alone or in combination)
renoprotection therapy goals 208, 209
Subject Index Aldosterone, plasminogen activator inhibitor-1 induction 163, 164, 168 Aminopeptidases angiotensin II processing 64 66, 214 diabetic expression 214, 215 Angiotensin I intrarenal compartmentalization
Hypertension and diabetic nephropathy
Hypertension and diabetic nephropathy Elisabeth R. Mathiesen Professor, Chief Physician, Dr sci Dep. Of Endocrinology Rigshospitalet, University of Copenhagen Denmark Hypertension Brain Eye Heart Kidney
DIVISION OF NEPHROLOGY
The Division s funding from the NIH has increased from $3.7 Million in 2001 to over $11 Million in 2006. DIVISION OF NEPHROLOGY DR. BARBARA MURPHY was voted President-Elect of the American Society of Transplantation
SLOWING PROGRESSION OF KIDNEY DISEASE. Mark Rosenberg MD University of Minnesota
SLOWING PROGRESSION OF KIDNEY DISEASE Mark Rosenberg MD University of Minnesota OUTLINE 1. Epidemiology of progression 2. Therapy to slow progression a. Blood Pressure control b. Renin-angiotensin-aldosterone
Cardiovascular Protection and the RAS
Cardiovascular Protection and the RAS Katalin Kauser, MD, PhD, DSc Senior Associate Director, Boehringer Ingelheim Pharmaceutical Inc. Micardis Product Pipeline Scientific Support Ridgefield, CT, USA Cardiovascular
Position Statement on ALDOSTERONE ANTAGONIST THERAPY IN CHRONIC HEART FAILURE
Position Statement on ALDOSTERONE ANTAGONIST THERAPY IN CHRONIC HEART FAILURE Over 8,000 patients have been studied in two well-designed placebo-controlled outcome-driven clinical trials to evaluate the
Prof. Andrzej Wiecek Department of Nephrology, Endocrinology and Metabolic Diseases Medical University of Silesia Katowice, Poland.
What could be the role of renal denervation in chronic kidney disease? Andrzej Wiecek, Katowice, Poland Chairs: Peter J. Blankestijn, Utrecht, The Netherlands Jonathan Moss, Glasgow, UK Prof. Andrzej Wiecek
Review of Rituximab and renal transplantation. Dr.E Nemati. Professor of Nephrology
Review of Rituximab and renal transplantation Dr.E Nemati Professor of Nephrology Introductio n Rituximab is a chimeric anti-cd20 monoclonal antibody. The CD20 antigen is a transmembrane nonglycosylated
Obesity mediated hypertension and renal dysfunction
Obesity mediated hypertension and renal dysfunction Gergely Bodor Marion Hervouet Nicky Honnef Mariarosaria Malgadi Julie Robert Tutor: Pr Alina Parvu Objectives 1. Introduction 2. Renal structural and
The organs of the human body were created to perform ten functions among which is the function of the kidney to furnish the human being with thought.
The organs of the human body were created to perform ten functions among which is the function of the kidney to furnish the human being with thought. Leviticus Rabba 3 Talmud Berochoth 6 1 b Outline &
578 Index. Eplerenone, 7, 29, 119, 120, 126, 275, 276,
Index A AC. See Adenylate cyclase (AC) ACEI. See Angiotensin converting enzyme inhibitors (ACEI) Adenosine, 179, 180, 182 184, 191, 196 198 Adenosine A1 receptor, 179 183, 186, 190 198 Adenylate cyclase
Case Presentation Turki Al-Hussain, MD
Case Presentation Turki Al-Hussain, MD Director, Renal Pathology Chapter Saudi Society of Nephrology & Transplantation Consultant Nephropathologist & Urological Pathologist Department of Pathology & Laboratory
hyperlipidemia in CKD DR MOJGAN MORTAZAVI ASSOCIATE PROFESSOR OF NEPHROLOGY ISFAHAN KIDNEY DISEASES RESEARCH CENTER
Management of hyperlipidemia in CKD DR MOJGAN MORTAZAVI ASSOCIATE PROFESSOR OF NEPHROLOGY ISFAHAN KIDNEY DISEASES RESEARCH CENTER Background on Dyslipidemia in CKD In advanced chronic kidney disease (CKD),
Prof. Armando Torres Nephrology Section Hospital Universitario de Canarias University of La Laguna Tenerife, Canary Islands, Spain.
Does RAS blockade improve outcomes after kidney transplantation? Armando Torres, La Laguna, Spain Chairs: Hans De Fijter, Leiden, The Netherlands Armando Torres, La Laguna, Spain Prof. Armando Torres Nephrology
Cardiovascular Disease in CKD. Parham Eftekhari, D.O., M.Sc. Assistant Clinical Professor Medicine NSUCOM / Broward General Medical Center
Cardiovascular Disease in CKD Parham Eftekhari, D.O., M.Sc. Assistant Clinical Professor Medicine NSUCOM / Broward General Medical Center Objectives Describe prevalence for cardiovascular disease in CKD
Echocardiography analysis in renal transplant recipients
Original Research Article Echocardiography analysis in renal transplant recipients S.A.K. Noor Mohamed 1*, Edwin Fernando 2, 1 Assistant Professor, 2 Professor Department of Nephrology, Govt. Stanley Medical
HLA and Non-HLA Antibodies in Transplantation and their Management
HLA and Non-HLA Antibodies in Transplantation and their Management Luca Dello Strologo October 29 th, 2016 Hystory I 1960 donor specific antibodies (DSA): first suggestion for a possible role in deteriorating
Protecting the heart and kidney: implications from the SHARP trial
Cardiology Update, Davos, 2013: Satellite Symposium Protecting the heart and kidney: implications from the SHARP trial Colin Baigent Professor of Epidemiology CTSU, University of Oxford S1 First CTT cycle:
Literature Review Transplantation
Literature Review 2010- Transplantation Alexander Wiseman, M.D. Associate Professor, Division of Renal Diseases and Hypertension Medical Director, Kidney and Pancreas Transplant Programs University of
Faiez Zannad, MD, PhD, Nancy
1 Biotargets, drug discovery and therapeutic innovation. How French clinical networks can accelerate the discovery of new treatments in the field of cardiovascular and metabolic diseases? Faiez Zannad,
Abstract Categories Acute Kidney Injury Bioengineering and Informatics Cell Biology Chronic Kidney Disease (Non-Dialysis)
Acute Kidney Injury 001 AKI: Basic Basic studies on the pathophysiology of AKI in models ranging from cultured cells or subcellular reconstitution experiments to animal or human studies involving renal
Novel Approaches for Recognition and Management of Life Threatening Complications of AKI and CKD: Focus on Acute Cardiorenal Syndromes
Novel Approaches for Recognition and Management of Life Threatening Complications of AKI and CKD: Focus on Acute Cardiorenal Syndromes Peter A. McCullough, MD, MPH Baylor University Medical Center, Dallas
Left ventricular hypertrophy: why does it happen?
Nephrol Dial Transplant (2003) 18 [Suppl 8]: viii2 viii6 DOI: 10.1093/ndt/gfg1083 Left ventricular hypertrophy: why does it happen? Gerard M. London Department of Nephrology and Dialysis, Manhes Hospital,
Discovery and development of regenerative medicine products comprised of autologous cells and biomaterials. ISCT September 28, 2010 San Francisco, CA
Discovery and development of regenerative medicine products comprised of autologous cells and biomaterials ISCT September 28, 2010 San Francisco, CA 1 Tengion s products catalyze regeneration INPUTS OUTPUTS
LXIV: DRUGS: 4. RAS BLOCKADE
LXIV: DRUGS: 4. RAS BLOCKADE ACE Inhibitors Components of RAS Actions of Angiotensin i II Indications for ACEIs Contraindications RAS blockade in hypertension RAS blockade in CAD RAS blockade in HF Limitations
Management of Rejection
Management of Rejection I have no disclosures Disclosures (relevant or otherwise) Deborah B Adey, MD Professor of Medicine University of California, San Francisco Kidney and Pancreas Transplant Center
Long-Term Post Transplantation Care. Pathogenesis and Management of Long Term Cardiovascular and Metabolic Complications in Renal Transplantation
3 rd ERA-EDTA CME COURSE Long-Term Post Transplantation Care Pathogenesis and Management of Long Term Cardiovascular and Metabolic Complications in Renal Transplantation What the Non Transplant-Nephrologists
FABRY DISEASE: Phenotypic Spectrum Genotype/Phenotype Correlations Enzyme Replacement Therapy (ERT) R. J. Desnick, Ph.D., M.D.
FABRY DISEASE: Phenotypic Spectrum Genotype/Phenotype Correlations Enzyme Replacement Therapy (ERT) R. J. Desnick, Ph.D., M.D. Director, International Center for Fabry Disease Dean for Genetic & Genomic
Kidneytransplant pathologyrelatedto immunosuppressiveagents
Kidneytransplant pathologyrelatedto immunosuppressiveagents Helmut Hopfer Pathologie Women, 53 years old. 16 months after kidney transplantation for diabetic nephropathy. Metabolicsyndromeandcoronaryheartdisease.
Effects of Kidney Disease on Cardiovascular Morbidity and Mortality
Effects of Kidney Disease on Cardiovascular Morbidity and Mortality Joachim H. Ix, MD, MAS Assistant Professor in Residence Division of Nephrology University of California San Diego, and Veterans Affairs
INI-CRCT (Cardiovascular and Renal Clinical Trialists) Coord: Prof. P. Rossignol, Nancy Inserm 9501 CIC
INI-CRCT (Cardiovascular and Renal Clinical Trialists) Coord: Prof. P. Rossignol, Nancy Inserm 9501 CIC CIC-INSERM, CHU de Nancy- Université de Lorraine UMR Inserm U 1116 Heart failure and Hypertension
Recognition and Treatment of Chronic Allograft Dysfunction
Recognition and Treatment of Chronic Allograft Dysfunction Alexander Wiseman, M.D. Associate Professor, Division of Renal Diseases and Hypertension Medical Director, Kidney and Pancreas Transplant Programs
Intruduction PSI MODE OF ACTION AND PHARMACOKINETICS
Multidisciplinary Insights on Clinical Guidance for the Use of Proliferation Signal Inhibitors in Heart Transplantation Andreas Zuckermann, MD et al. Department of Cardio-Thoracic Surgery, Medical University
Dr. Khairy Abdel Dayem. Professor of Cardiology Ain-Shams University
Dr. Khairy Abdel Dayem Professor of Cardiology Ain-Shams University RALES Randomized Aldactone Evaluation Study 1. NEJM 1999 2. Bertram Pitt 3. 1660 Class III and IV HF patients 4. EF 35% 5. 841 placebo
COGNITIVE ALTERATIONS IN CHRONIC KIDNEY DISEASE K K L E E
COGNITIVE ALTERATIONS IN CHRONIC KIDNEY DISEASE K K L E E Attention Problem Solving Language Cognitive Domains Decision Making Memory Reasoning The Cardiovascular Health Cognition Study shows higher S
TRANSPLANTATION IN DIABETIC PATIENTS. A.Tarik Kizilisik, MD, MSc, FACS, FICS Director & Primary Transplant Surgeon Lutheran Transplant Center
TRANSPLANTATION IN DIABETIC PATIENTS A.Tarik Kizilisik, MD, MSc, FACS, FICS Director & Primary Transplant Surgeon Lutheran Transplant Center Diabetes is the pandemic of the new millennium 24 million diabetics
M2 TEACHING UNDERSTANDING PHARMACOLOGY
M2 TEACHING UNDERSTANDING PHARMACOLOGY USING CVS SYSTEM AS AN EXAMPLE NIGEL FONG 2 JAN 2014 TODAY S OBJECTIVE Pharmacology often seems like an endless list of mechanisms and side effects to memorize. To
Special Challenges and Co-Morbidities
Special Challenges and Co-Morbidities Renal Disease/ Hypertension/ Diabetes in African-Americans M. Keith Rawlings, MD Medical Director Peabody Health Center AIDS Arms, Inc Dallas, TX Chair, Internal Medicine
JOSHUA K. KAYIMA INTERLINKING CARDIOVASCULAR DISEASE, CHRONIC KIDNEY DISEASE, AND OBESITY
INTERLINKING CARDIOVASCULAR DISEASE, CHRONIC KIDNEY DISEASE, AND OBESITY JOSHUA K. KAYIMA ASSOCIATE PROFESSOR DEPT. OF CLINICAL MEDICINE AND THERAPEUTICS UNIVERSITY OF NAIROBI Introduction According to
Antialdosterone treatment in heart failure
Update on the Treatment of Chronic Heart Failure 2012 Antialdosterone treatment in heart failure 전남의대윤현주 Chronic Heart Failure Prognosis of Heart failure Cecil, Text book of Internal Medicine, 22 th edition
Disclosure Statement. Objectives. Novel Therapies for Vascular Access Dysfunction: OptiflowDevice, Gene Therapy, and Sirolimus Wrap 2/29/2012
Novel Therapies for Vascular Access Dysfunction: OptiflowDevice, Gene Therapy, and Sirolimus Wrap Neointimal Hyperplasia Characteristic Lesion of Dialysis Access Dysfunction AVF Timmy Lee, M.D., M.S.P.H.,
Pathogenesis of IgA Nephropathy. Shokoufeh Savaj MD Associate Professor of Medicine Firoozgar hospital- IUMS
Pathogenesis of IgA Nephropathy Shokoufeh Savaj MD Associate Professor of Medicine Firoozgar hospital- IUMS History Immunoglobin A nephropathy was first described by Berger and Hinglais in 1968 in Paris
Pathology of Hypertension
2016-03-07 Pathology of Hypertension Honghe Zhang honghezhang@zju.edu.cn Tel:88208199 Department of Pathology ❶ Genetic predisposition ❷ Dietary factors ❸ Environmental factors ❹ Others Definition and
Recurrent Idiopathic Membranous Glomerulonephritis After Kidney Transplantation and Successful Treatment With Rituximab
TRANSPLANTATION Recurrent Idiopathic Membranous Glomerulonephritis After Kidney Transplantation and Successful Treatment With Rituximab Khadijeh Makhdoomi, 1,2 Saeed Abkhiz, 1,2 Farahnaz Noroozinia, 1,3
Aldosterone Antagonism in Heart Failure: Now for all Patients?
Aldosterone Antagonism in Heart Failure: Now for all Patients? Inder Anand, MD, FRCP, D Phil (Oxon.) Professor of Medicine, University of Minnesota, Director Heart Failure Program, VA Medical Center 111C
Proceedings of the 34th World Small Animal Veterinary Congress WSAVA 2009
www.ivis.org Proceedings of the 34th World Small Animal Veterinary Congress WSAVA 2009 São Paulo, Brazil - 2009 Next WSAVA Congress : Reprinted in IVIS with the permission of the Congress Organizers PROTEINURIA
Case Report Beneficial Effect of Conversion to Belatacept in Kidney-Transplant Patients with a Low Glomerular-Filtration Rate
Case Reports in Transplantation, Article ID 190516, 4 pages http://dx.doi.org/10.1155/2014/190516 Case Report Beneficial Effect of Conversion to Belatacept in Kidney-Transplant Patients with a Low Glomerular-Filtration
Predicting and changing the future for people with CKD
Predicting and changing the future for people with CKD I. David Weiner, M.D. Co-holder, C. Craig and Audrae Tisher Chair in Nephrology Professor of Medicine and Physiology and Functional Genomics University
Doppler ultrasound, see Ultrasonography. Magnetic resonance imaging (MRI), kidney oxygenation assessment 75
Subject Index Acidemia, cardiorenal syndrome type 3 146 Acute Dialysis Quality Initiative (ADQI) acute kidney injury biomarkers, see Acute kidney injury; specific biomarkers cardiorenal syndrome, see specific
Faiez Zannad. Institut Lorrain du Coeur et des Vaisseaux. CIC - Inserm
Faiez Zannad Institut Lorrain du Coeur et des Vaisseaux CIC - Inserm Disclosure Faiez Zannad Grants BG Medicine, Roche Diagnostics. Consultant/Steering committees/event committees/ Data safety Monitoring
The use of pathology surrogate markers in Fabry Disease. Beth L. Thurberg MD PhD Vice President of Pathology Genzyme
Disclaimer: Presentation slides from the Rare Disease Workshop Series are posted by the EveryLife Foundation for Rare Diseases for educational purposes only. They are for use by drug development professionals
Prevalence of anemia and cardiovascular diseases in chronic kidney disease patients: a single tertiary care centre study
International Journal of Advances in Medicine Sathyan S et al. Int J Adv Med. 2017 Feb;4(1):247-251 http://www.ijmedicine.com pissn 2349-3925 eissn 2349-3933 Original Research Article DOI: http://dx.doi.org/10.18203/2349-3933.ijam20170120
ACEIs / ARBs NDHP dihydropyridine ( DHP ) ACEIs ARBs ACEIs ARBs NDHP. ( GFR ) 60 ml/min/1.73m ( chronic kidney disease, CKD )
005 16 175-180 1 1 ( chronic kidney disease, CKD ) 003 ( end-stage renal disease, ESRD ) Angiotensin-converting enzyme inhibitors ( ) angiotensin receptor blockers ( ) nondihydropyridine ( NDHP ) / NDHP
ΚΑΡΔΙΑΚΗ ΑΝΕΠΑΡΚΕΙΑ ΚΑΙ ΑΝΤΑΓΩΝΙΣΤΕΣ ΑΛΔΟΣΤΕΡΟΝΗΣ ΣΠΥΡΟΜΗΤΡΟΣ ΓΕΩΡΓΙΟΣ MD, FESC. E.Α Κ/Δ Γ.Ν.ΚΑΤΕΡΙΝΗΣ
ΚΑΡΔΙΑΚΗ ΑΝΕΠΑΡΚΕΙΑ ΚΑΙ ΑΝΤΑΓΩΝΙΣΤΕΣ ΑΛΔΟΣΤΕΡΟΝΗΣ ΣΠΥΡΟΜΗΤΡΟΣ ΓΕΩΡΓΙΟΣ MD, FESC. E.Α Κ/Δ Γ.Ν.ΚΑΤΕΡΙΝΗΣ Aldosterone is a mineralocorticoid hormone synthesized by the adrenal glands that has several regulatory
BK virus infection in renal transplant recipients: single centre experience. Dr Wong Lok Yan Ivy
BK virus infection in renal transplant recipients: single centre experience Dr Wong Lok Yan Ivy Background BK virus nephropathy (BKVN) has emerged as an important cause of renal graft dysfunction in recent
HYPERTENSIVE VASCULAR DISEASE
HYPERTENSIVE VASCULAR DISEASE Cutoffs in diagnosing hypertension in clinical practice sustained diastolic pressures >90 mm Hg, or sustained systolic pressures >140 mm Hg Malignant hypertension A small
RECURRENT AND DE NOVO RENAL DISEASES IN THE ALLOGRAFT. J. H. Helderman,MD,FACP,FAST
RECURRENT AND DE NOVO RENAL DISEASES IN THE ALLOGRAFT J. H. Helderman,MD,FACP,FAST Vanderbilt University Medical Center Professor of Medicine, Pathology and Immunology Medical Director, Vanderbilt Transplant
Case # 2 3/27/2017. Disclosure of Relevant Financial Relationships. Clinical history. Clinical history. Laboratory findings
Case # 2 Christopher Larsen, MD Arkana Laboratories Disclosure of Relevant Financial Relationships USCAP requires that all planners (Education Committee) in a position to influence or control the content
신장환자의혈압조절 나기영. Factors involved in the regulation of blood pressure
신장환자의혈압조절 K/DOQI Clinical practice guidelines on Hypertension and Antihypertensive agents in CKD 나기영 Factors involved in the regulation of blood pressure Renal function curve MAP (mmhg) Central role of
Contrast Induced Nephropathy
Contrast Induced Nephropathy O CIAKI refers to an abrupt deterioration in renal function associated with the administration of iodinated contrast media O CIAKI is characterized by an acute (within 48 hours)
Partial Nephrectomy: Does Ischemia Matter?
Partial Nephrectomy: Does Ischemia Matter? Karim Touijer, MD, MPH Attending Surgeon Memorial Sloan-Kettering Cancer Center Associate Professor of Urology Weill Cornell Medical College, New York No disclosures
2017 CST-Astellas Canadian Transplant Fellows Symposium. Management of Renal Dysfunction in Extra Renal Transplants
2017 CST-Astellas Canadian Transplant Fellows Symposium Management of Renal Dysfunction in Extra Renal Transplants Jeffrey Schiff, MD Dr. Jeffrey Schiff is an Assistant Professor of Medicine at the University
Abstract Categories. Acute Kidney Injury
Acute Kidney Injury 001 AKI: Basic Basic studies on the pathophysiology of AKI in models ranging from cultured cells or subcellular reconstitution experiments to animal or human studies involving renal
Heart Failure: Combination Treatment Strategies
Heart Failure: Combination Treatment Strategies M. McDonald MD, FRCP State of the Heart Symposium May 28, 2011 None Disclosures Case 69 F, prior MIs (LV ejection fraction 25%), HTN No demonstrable ischemia
CAD in Chronic Kidney Disease. Kuang-Te Wang
CAD in Chronic Kidney Disease Kuang-Te Wang InIntroduction What I am going to talk about: CKD and its clinical impact on CAD Diagnosis of CAD in CKD PCI / Revasc Outcomes in CKD CKD PCI CAD Ohtake T,
United States Renal Data System (USRDS) International Data Collection Form
United States Renal Data System (USRDS) International Data Collection Form This form is designed to solicit information on the population of End-Stage Renal Disease (ESRD) patients in your country who
Expanded Criteria Recipients: Are there any Limits
Expanded Criteria Recipients: Are there any Limits Andreas Paul, MD, MSc, FRCS Department of General-, Visceral- and Transplant Surgery, University Hospital Essen Ruhr Area 5.200 000 inhabitants University
Renal Cystic Disease. Dr H Bierman
Renal Cystic Disease Dr H Bierman Objectives Be able to diagnose renal cystic disease Genetic / non-genetic Be able to describe patterns of various renal cystic disease on routine imaging studies Be able
Exploring the Reno-Cardiac Connection. Protect your kidneys save your heart
Exploring the Reno-Cardiac Connection Protect your kidneys save your heart Heart Failure: a major health care problem ~23 million people with heart failure worldwide Heart failure increases progressively
Cyclosporine Nephrotoxicity and Early Posttransplant Hyperkalemia in Living-Donor Renal Recipients: Report of 4 Cases
case report Cyclosporine Nephrotoxicity and Early Posttransplant Hyperkalemia in Living-Donor Renal Recipients: Report of 4 Cases Svetlana Pavleska-Kuzmanovska, 1 Zivko Popov, 2 Ognen Ivanovski, 2 Vesna
Impact of Subclinical Rejection on Transplantation
Trends in Transplantation 2007;1:56-60 Impact of Subclinical Rejection on Transplantation David N. Rush for the Winnipeg Transplant Group Transplant Manitoba Adult Kidney Program, University of Manitoba,
Diabetes and kidney disease.
Diabetes and kidney disease. What are the implications? Can it be prevented? Nice 18 june 2010 Lars G Weiss. M.D. Ph.D. Department of Neprology Central Hospital Karlstad Sweden Diabetic nephropathy vs
Na + /K + interaction in the kidney, blood vessels, brain, and beyond
Na + /K + interaction in the kidney, blood vessels, brain, and beyond Horacio J. Adrogué, M.D. Professor of Medicine, Baylor College of Medicine Chief, Clinical Nephrology and Hypertension. Houston Methodist
OUT OF DATE. Choice of calcineurin inhibitors in adult renal transplantation: Effects on transplant outcomes
nep_734.fm Page 88 Friday, January 26, 2007 6:47 PM Blackwell Publishing AsiaMelbourne, AustraliaNEPNephrology1320-5358 2006 The Author; Journal compilation 2006 Asian Pacific Society of Nephrology? 200712S18897MiscellaneousCalcineurin
Pathological back-ground of renal transplant pathology and important mile-stones of the Banff classification
Banff 1 Banff Pathological back-ground of renal transplant pathology and important mile-stones of the Banff classification Department of Nephrology, Japanese Red Cross Nagoya Daini Hospital Morozumi Kunio,
Diabetes, Obesity and Heavy Proteinuria
Diabetes, Obesity and Heavy Proteinuria Clinical Case 41 yo Black woman with heavy proteinuria History 2014: noted to have proteinuria on routine lab testing (1.1g/g). 1+ edema. Blood pressure has been
Développement clinique du Patiromer et futures perspectives
Développement clinique du Patiromer et futures perspectives Professor Patrick Rossignol Inserm CIC-P 14-33, CHRU de Nancy-University de Lorraine, ALTIR Disclosures consultant: AstraZeneca, Bayer, CTMA,
Crisis Management During Liver Transplant Surgery Liver and Intensive Care Group of Europe Newcastle upon Tyne 2005
Crisis Management During Liver Transplant Surgery Liver and Intensive Care Group of Europe Newcastle upon Tyne 2005 M. Susan Mandell M.D. Ph. D. Department of Anesthesiology University of Colorado Health
The Cardiorenal Syndrome in Heart Failure
The Cardiorenal Syndrome in Heart Failure Van N Selby, MD Assistant Professor of Medicine Advanced Heart Failure Program, UCSF October 9, 2015 Disclosures None 1 Cardiorenal Syndrome (CRS) A pathophysiologic
DIASTOLIC HEART FAILURE
DIASTOLIC HEART FAILURE M Mohsen Ibrahim, MD Alexandria, Proposed Criteria for Diastolic Heart Failure ESC Working Group (EHJ 1998) CHF signs/symptoms EF 45% Hemodynamic or echo evidence of diastolic dysfunction
Chronic injury to the microcirculation in EMB
Chronic injury to the microcirculation in EMB Dylan V Miller MD M Patricia Revelo MD Disclosures Miller: None Revelo: None Goals & Objectives Characterize the tissue-level pathologic changes occurring
Long-term prognosis of BK virus-associated nephropathy in kidney transplant recipients
Original Article Kidney Res Clin Pract 37:167-173, 2018(2) pissn: 2211-9132 eissn: 2211-9140 https://doi.org/10.23876/j.krcp.2018.37.2.167 KIDNEY RESEARCH AND CLINICAL PRACTICE Long-term prognosis of BK
Shuma Hirashio 1,2, Shigehiro Doi 1 and Takao Masaki 1*
Hirashio et al. Renal Replacement Therapy (2018) 4:24 https://doi.org/10.1186/s41100-018-0164-9 CASE REPORT Open Access Magnetic resonance imaging is effective for evaluating the therapeutic effect of
Renal Pathology- Transplantation. Eva Honsova Institute for Clinical and Experimental Medicine Prague, Czech Republic
Renal Pathology- Transplantation Eva Honsova Institute for Clinical and Experimental Medicine Prague, Czech Republic eva.honsova@ikem.cz Kidney has a limited number of tissue reactions by which the kidney
Objectives. Pre-dialysis CKD: The Problem. Pre-dialysis CKD: The Problem. Objectives
The Role of the Primary Physician and the Nephrologist in the Management of Chronic Kidney Disease () By Brian Young, M.D. Assistant Clinical Professor of Medicine David Geffen School of Medicine at UCLA
Morbidity & Mortality from Chronic Kidney Disease
Morbidity & Mortality from Chronic Kidney Disease Dr. Lam Man-Fai ( 林萬斐醫生 ) Honorary Clinical Assistant Professor MBBS, MRCP, FHKCP, FHKAM, PDipID (HK), FRCP (Edin, Glasg) Hong Kong Renal Registry Report
Anticoagulation, atrial fibrillation in elderly patients with chronic kidney disease
Anticoagulation, atrial fibrillation in elderly patients with chronic kidney disease Zbigniew Heleniak M.D. Ph.D. Department of Nephrology, Transplantology and Internal Medicine Medical University of Gdansk
Since the initial description of angiotensin II mediated
CLINICAL CARDIOLOGY: PHYSICIAN UPDATE Manipulation of the Renin-Angiotensin System Michael M. Givertz, MD Since the initial description of angiotensin II mediated hypertension 40 years ago, basic and clinical
HYPERTENSION IN CKD. LEENA ONGAJYOOTH, M.D., Dr.med RENAL UNIT SIRIRAJ HOSPITAL
HYPERTENSION IN CKD LEENA ONGAJYOOTH, M.D., Dr.med RENAL UNIT SIRIRAJ HOSPITAL Stages in Progression of Chronic Kidney Disease and Therapeutic Strategies Complications Normal Increased risk Damage GFR
KDIGO LESSONS LEARNED FROM NEPHROLOGY TRIALS WITH RESPECT TO HEART FAILURE
LESSONS LEARNED FROM NEPHROLOGY TRIALS WITH RESPECT TO HEART FAILURE Dr. Christopher T Chan Director Division of Nephrology University Health Network Professor of Medicine University of Toronto Disclosure
Clinical Pearls in Renal Medicine
Clinical Pearls in Renal Medicine Joel A. Gordon MD Professor of Medicine Nephrology Division Staff Physician Kidney Disease and Blood Pressure Clinic Disclosures None of my financial holdings will have
In the name of GOD. Animal models of cardiovascular diseases: myocardial infarction & hypertension
In the name of GOD Animal models of cardiovascular diseases: myocardial infarction & hypertension 44 Presentation outline: Cardiovascular diseases Acute myocardial infarction Animal models for myocardial
RECURRENT AND DE NOVO RENAL DISEASES IN THE ALLOGRAFT
RECURRENT AND DE NOVO RENAL DISEASES IN THE ALLOGRAFT HISTOPATHOLOGIC DISORDERS AFFECTING THE ALLOGRAFT OTHER THAN REJECTION RECURRENT DISEASE DE NOVO DISEASE TRANSPLANT GLOMERULOPATHY Glomerular Non-glomerular
FY 2011 WISEWOMAN Approved ICD-9 Code List
243 Congenital hypothyroidism 245.0 Thyroiditis; Acute thyroiditis 245.1 Thyroiditis; Subacute thyroiditis 245.2 Thyroiditis; Chronic lymphocytic thyroiditis 245.3 Thyroiditis; Chronic fibrous thyroiditis
RENAL HISTOPATHOLOGY
RENAL HISTOPATHOLOGY Peter McCue, M.D. Department of Pathology, Anatomy & Cell Biology Sidney Kimmel Medical College There are no conflicts of interest. 1 Goals and Objectives! Goals Provide introduction
POOR LONG-TERM SURVIVAL AFTER ACUTE MYOCARDIAL INFARCTION AMONG PATIENTS ON LONG-TERM DIALYSIS
POOR LONG-TERM SURVIVAL AFTER ACUTE MYOCARDIAL INFARCTION AMONG PATIENTS ON LONG-TERM DIALYSIS CHARLES A. HERZOG, M.D., JENNIE Z. MA, PH.D., AND ALLAN J. COLLINS, M.D. ABSTRACT Background Cardiovascular
Cardiovascular Risk Reduction in Kidney Transplant Recipients
Cardiovascular Risk Reduction in Kidney Transplant Recipients Rainer Oberbauer R.O. AUG 2010 CV Mortality in ESRD compared to the general population R.O.2/32 Modified from Foley et al. AJKD 32 (suppl3):
Scientific conclusions and detailed explanation of the scientific grounds for the differences from the PRAC recommendation
Annex I Scientific conclusions, grounds for variation to the terms of the marketing authorisations and detailed explanation of the scientific grounds for the differences from the PRAC recommendation 1
Histopathology of renal failure after heart transplantation: A diverse spectrum
http://www.jhltonline.org Histopathology of renal failure after heart transplantation: A diverse spectrum Sean P. Pinney, MD, a Revathi Balakrishnan, MD, b Steven Dikman, MD, c Ajith Nair, MD, a Kimmarie
Mayo Clinic Proceedings August 2018 Issue Summary
Greetings, I am Dr Karl Nath, the Editor-in-Chief of Mayo Clinic Proceedings, and I am pleased to welcome you to the multimedia summary for the journal s August 2018 issue. There are 4 articles this month