Repair of Mitral Valve Prolapse with a Novel Leaflet Plication Clip in an Animal Model
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1 Repair of Mitral Valve Prolapse with a Novel Leaflet Plication Clip in an Animal Model Eric N. Feins 1, Haruo Yamauchi 1, Gerald R. Marx 2, Franz P. Freudenthal 3, Hua Liu 1, Pedro J. del Nido 1, Nikolay V. Vasilyev 1 1 Department of Cardiac Surgery, Boston Children s Hospital 2 Department of Cardiology, Boston Children s Hospital 3 Department of Pediatric Cardiology, Kardiozentrum, La Paz, Bolivia May 8, 2013
2 Disclosures Franz Freudenthal, MD is employed by PFM Bolivia the manufacturer of the device prototype. Funding: NIH National Heart, Lung and Blood Institute. Grant #: 5R01HL Image-guided Intracardiac Beating-Heart Surgery (PJdN) The equipment & technology used in this study were purchased using academic funds. The authors had full control of the study design, methods used, outcome measurements, analysis of data, and production of the written report.
3 Background Mitral regurgitation (MR) is the 2 nd most common valve-related indication for cardiac surgery Degenerative MV disease is the predominant pathology: Chordae tendineae elongation/rupture Excessive/redundant leaflet tissue Leaflet prolapse Malcoaptation MR Adapted from Cohn LH, ed. Cardiac Surgery in the Adult McGraw-Hill
4 Mitral Valve Repair Segmental leaflet resection Adapted from Cohn LH, ed. Cardiac Surgery in the Adult McGraw-Hill Leaflet plication foldoplasty Adapted from Ellis FH Jr, Frye RL, McGoon DC. Results of reconstructive operations for mitral insufficiency due to ruptured chordae tendineae. Surgery. 1966;59: Mitral valve repair outcomes: 12.6% composite adverse events rate 1 Many high-risk patients are deemed non-operative candidates Emergence of minimally-invasive & beating-heart repair techniques 1 Liff DA, et al. Novel percutaneous therapyies for mitral regurgitation: In: Franco KL, Thourani VH, eds. Cardiothoracic Surgery Review. New York: Lippincott Williams & Wilkins; 2012:
5 Beating-Heart Mitral Valve Repair Numerous devices in development Indirect annuloplasty via coronary sinus Artificial chordae implantation Edge-to-edge leaflet repair: MitraClip (Abbott Vascular) Adapted from St. Goar FG, et al. Endovascular edge-to-edge-mitral valve repair: Short-term results in a porcine model. Circulation. 2003;108: Adapted from Chiam PTL, Ruiz CE. Percutaneous Transcatheter Mitral Valve Repair. A classification of the technology. JACC: Cardiovascular interventions. 2011; 2(1) No devices achieve isolated leaflet plication
6 Leaflet Plication Clip Folded nitinol wire 0.44mm diameter Central loop (*) Sharpened arms ( ) Opened state for leaflet grasping Closed, resting state for leaflet plication Deployment device for open-heart implantation/testing 1mm * Open Closed * Deployment device
7 Implantation & Mechanism of Action
8 Study Aim & Design Assess short-term performance of the leaflet plication clip for MVP repair in an animal model Open-heart clip implantation Echocardiographic assessment
9 Yorkshire female swine (N=7, weight = 60-73kg) Surgery: Left thoracotomy (4 th intercostal space) 2D/3D epicardial echo (baseline) Cardiopulmonary bypass #1 Open-heart chordae cutting via left atriotomy MR creation 2D/3D epicardial echo (off bypass) Cardiopulmonary bypass #2 Open-heart Leaflet plication clip application Direct/epicardial echo off CPB (2hr post) Euthanasia & explant Methods MVP/MR creation Leaflet plication clip 2HR Euthanasia & explant Echo Echo Echo
10 Echocardiographic Analysis MR Grade: 2D color Doppler imaging 0-4 scale: None (0), Trivial (1), Mild (2), Moderate (3), Severe (4) Vena contract area Coaptation height (CH) Posterior mitral leaflet mobility (Δθ) AL PL CH (Δθ) = θ d θ s θ d = diastolic posterior leaflet angle θ s = systolic posterior leaflet angle θ s θ d
11 Results All animals survived the surgical procedure 2-4 primary and secondary chordae were cut in each animal to create MVP/MR Successful clip implantation in all cases without significant leaflet trauma No evidence of thrombosis on/around clip No evidence of clip embolism 2 cases of slight clip movement tangling with underlying 2 chordae shifting to oblique position
12 MR Grade (2D color Doppler) Baseline Post-Chordae cutting P2 flail Post-Clip placement
13 MR Grade MR Grade 4.0 P < NS Pre-MR Post-MR Clip Median MR grade: Trivial (1+) Moderate-severe (3.5) Mild (2+)
14 Vena Contracta Area (cm 2 ) Vena Contract Area 0.40 NS Pre-MR Post-MR Clip Mean VCA: 0.08cm cm cm 2
15 Coaptation Height (cm) Leaflet Mobility, Δθ ( ) Coaptation Height & Leaflet Mobility Coaptation Height Posterior Leaflet Mobility NS Pre-MR Post-MR Clip 35.0 NS Pre-MR Post-MR Clip
16 Conclusions & Future Work The leaflet plication clip reduces MR grade in the setting of MVP in an acute animal model by solely plicating the prolapsed segment Coaptation height is restored to baseline Leaflet mobility is not hindered by the clip Adjunctive repair techniques (annuloplasty) Minimally-invasive development Mini-mitral & Robotic techniques Image-guided beating-heart approaches
17 Thank You
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