Case Report Accelerated Idioventricular Rhythm During Ajmaline Test: a Case Report
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1 474 Case Report Accelerated Idioventricular Rhythm During Ajmaline Test: a Case Report Antonio Sorgente, MD 1,2, Yoshinao Yazaki, MD 1, Lucio Capulzini, MD 1, Andrea Sarkozy, MD 1, Carlo de Asmundis, MD 1, Gian-Battista Chierchia, MD 1, Stephan-Andreas Müller-Burri, MD 1, Pedro Brugada, MD, PhD 1. 1 Heart Rhythm Management Center, UZ Brussel-VUB, Laarbeeklaan 101, 1090 Brussels (Belgium) 2 University of L Aquila, Piazza Salvatore Tommasi 1, Coppito, L'Aquila (Italy) Address for Correspondence: Antonio Sorgente, MD, Heart Rhythm Management Center UZ Brussel-VUB, Laarbeeklaan 101, 1090 Brussels (Belgium). sorgente.antonio/at/gmail.com Abstract We present an unusual transient pro-arrhythmic effect of ajmaline in a patient with resuscitated cardiac arrest and a left ventricular apical aneurysm. We discuss the clinical presentation and the possible physio-pathological explanation for this new pro-arrhythmic effect linked to administration of intravenous ajmaline. Keywords: Brugada syndrome, ajmaline test, accelerated idioventricular rhythm Introduction Brugada syndrome (BrS) is a well-recognized arrhythmogenic disease associated with an increased risk of sudden death related to ventricular tachyarrhythmias or ventricular fibrillation [1]. Sodium channel blockers drugs help clinicians to overcome one of the major characteristics of the disease, the wide variation in the ECG pattern [2]. Among sodium channel blockers, ajmaline has been demonstrated to be the one with highest predictive power [3], possibly because of its kinetics and strength of rate-dependent sodium channel blocking effects. A potential pro-arrhythmic effect of class I drugs has been reported [4]. Ajmaline challenge has been associated with lethal arrhythmias (polymorphic ventricular tachycardias and ventricular fibrillation), even in patients without BrS [5]. Case presentation We present the case of a 29 year-old man admitted to our hospital after a resuscitated cardiac arrest. His family history was negative for sudden cardiac death and channelopathies. His past medical history was unremarkable: the patient was completely asymptomatic and never complained of syncope or palpitations. Moreover, on clinical examination he didn't show any apparent abnormality. Electrocardiographic findings were completely normal. An exercise testing was clinically and electrically negative but rare isolated ventricular ectopic beats were documented during the test and in the recovery phase. For this reason the patient was planned
2 Antonio Sorgente, Yoshinao Yazaki, Lucio Capulzini, Andrea Sarkozy, 475 for a 24 hour Holter ECG registration. In the afternoon following the exercise testing, during a small effort, the patient experienced cardiac arrest. In the emergency room, he was found to be in ventricular fibrillation. Four DC shocks and iv adrenaline and cardio-pulmonary reanimation maneuvers obtained restoration of vital signs and sinus rhythm. The ECG after resuscitation showed non-specific abnormalities of the repolarization in the infero-lateral leads (Figure 1A). The patient had full recovery from the neurological point of view. Cardiac magnetic resonance showed late-enhancement of the left ventricular apex associated with dyskinesia in the same region and of the antero-septal portion of the same ventricle. Coronary angiography and coronary computed tomography didn't reveal any coronary artery abnormalities or critical stenosis. Echocardiographic evaluation demonstrated a left ventricular ejection fraction of 40% and confirmed the cardiac magnetic resonance findings. Final diagnosis was resuscitated cardiac arrest in a patient with left ventricular apical aneurysm of unknown origin (ischemic vs congenital). The patient finally underwent implantation of a defibrillator (ICD). Figure 1A: Baseline ECG showing aspecific repolarization abnormalities in the infero-lateral leads. Figure 1B: ECG showing the beginning of one episode of accelerated idioventricular rhythm (AIVR). Black arrows show P waves and isorhythmic AV dissociation. RR intervals shown on the top of the figure are expressed in ms.
3 Antonio Sorgente, Yoshinao Yazaki, Lucio Capulzini, Andrea Sarkozy, 476 Figure 1C: ECG showing consecutively the end of the previous episode of AIVR and the beginning of another one. Black arrows show P waves and isorhythmic AV dissociation. RR intervals shown on the top of the figure are expressed in ms. At the end of the hospitalization, an ajmaline test was performed to exclude BrS. The ajmaline test (1mg/kg of body weight) was negative for BrS, but, after 0.7 mg/kg injection (49 mg complexively), we documented an accelerated idioventricular rhythm (AIVR) with a heart rate of 95 bpm (Figure 1B). Diagnosis was confirmed after the evidence of AV dissociation and by a few fusion beats (Figure 1B and 1C). AIVR morphology was right bundle branch block (RBBB) and left anterior hemiblock (LAH). AIVR was preceded by a slight prolongation of the PQ interval (from 150 to 190 ms) and the QRS interval (from 95 ms to 130 ms). The arrhythmia ended spontaneously after termination of ajmaline infusion. Discussion To the best of our knowledge, our case report is the first to describe an AIVR during ajmaline test in a patient with a resuscitated cardiac arrest and with a left ventricular apical aneurysm. AIVR is defined as 3 or more successive wide QRS beats at a rate close to the baseline rhythm, with a maximal difference of 10-15% and with a heart rate between 100 and 120 bpm. AIVR is found to be the most common reperfusion arrhythmia in pre-thrombolytic and thrombolytic era: it is usually well tolerated [6-8] and no specific antiarrhythmic treatment is recommended apart from removing the suspected cause [9]. AIVR is believed to result from abnormal automaticity of the subendocardial Purkinje fibers owing to the washout phenomenon during infarct-related artery reperfusion [10]. Other investigators suggested triggered activity based on delayed afterdepolarizations as the underlying mechanism [11]. No association with ajmaline infusion has been described until now in the literature. Ajmaline test is a well-recognized diagnostic tool used to unmask the electrocardiographic pattern of BrS in patients with resuscitated cardiac arrest or syncopes and in genetic carriers belonging to families affected by this pathology [12]. Among the class I blockers, ajmaline is considered the most powerful to reveal the electrocardiographic alterations typical of BrS. Among the others, propafenone has been demonstrated to be a weaker agent, probably due to the associated block of I to channels. Both therapeutic, toxic and proarrhythmic effects of all sodium channel blockers are
4 Antonio Sorgente, Yoshinao Yazaki, Lucio Capulzini, Andrea Sarkozy, 477 manifested on the ECG by a different degree of PR and QRS prolongation [13]. One large study using ajmaline to diagnose BrS [14] revealed a very low incidence of ventricular tachycardias (VT), around 1.3 %. All episodes of VT documented in this study were polymorphic, degenerated in ventricular fibrillation and occurred in patients in whom drug administration after the appearance of diagnostic Brugada-type ECG changes was not discontinued. Our case substantially differs from the latter for different reasons: 1) our patient had a negative ajmaline test; 2) echocardiography showed left apical ventricular aneurysm and 3) the arrhythmia related to the intravenous administration of ajmaline was an AIVR and not a VT. Triggered activity could be addressed as potential electrophysiological mechanism leading to the cited arrhythmia, seen the capability of ajmaline of inducing early afterdepolarizations in the Purkinje fibers [15]. Another hypothesis which could explain the AIVR is macro-reentry. Indeed, class I antiarrhythmic drugs have demonstrated to potentially cause monomorphic tachycardia linked to a shortening of activation wavelength below the physical length of a preformed reentry circuit [16]. We can hypothesize an equal contribution of this two mechanisms in the physio-pathology of the cited arrhythmia in our patient. We think in fact that pathological findings evidenced by the echocardiography and the magnetic resonance together with the prolongation of conduction associated with the block of Na channels could favor a slow reentry between the left anterior and the left posterior fascicle, determining the morphology of RBBB and LAH. We would exclude a toxic effect of the ajmaline, since the AIVR appeared already before reaching the maximal usual dose of 1 mg/kg, given to elicit BrS ECG pattern. Ajmaline-related AIVR has never been reported. In this case report AIVR was probably favored by the presence of a left ventricular apical aneurysm. Our case report postulates that ajmaline induced AIVR increasing triggered activity of Purkinje fibers or decreasing the conduction on the two fascicles of the left bundle branch, determining a slow macro-reentry in the left bundle branch. Further investigation is needed to define the mechanism underlying this finding. References 1. Brugada P, Brugada J. Right bundle branch block, persistent ST segment elevation and sudden cardiac death: a distinct clinical and electrocardiographic syndrome. A multicenter report. J Am Coll Cardiol 1992;20: Veltmann C, Schimpf R, Echternach C, et al. A prospective study on spontaneous fluctuations between diagnostic and non-diagnostic ECGs in Brugada syndrome: implications for correct phenotyping and risk stratification. Eur Heart J 2006;27: Brugada P, Brugada J, Brugada R. Localized right ventricular morphological abnormalities in patients with the Brugada syndrome: what is their significance? Eur Heart J 2001;22: Brugada R, Brugada J, Antzelevitch C et al. Sodium channel blockers identify risk for sudden death in patients with ST-segment elevation and right bundle branch block but structurally normal hearts. Circulation 2000;101: Wellens HJ, Bar FW, Vanagt EJ. Death after Ajmaline administration. Am J Cardiol 1980;45: Goldberg S, Greenspon AJ, Urban PL, et al. Reperfusion arrhythmias: Amarker of restoration of antegrade flow during intracoronary thrombolysis for acute myocardial infarction. Am Heart J 1983;105: Gressin V, Louvard Y, Pezzano M, et al. Holter recording of ventricular arrhythmias during
5 Antonio Sorgente, Yoshinao Yazaki, Lucio Capulzini, Andrea Sarkozy, 478 intravenous thrombolysis for acute myocardial infarction. Am J Cardiol 1992;69: Gorgels APM, Vos MA, Letsch IS, et al. Usefulness of the accelerated idioventricular rhythm as a marker for myocardial necrosis and reperfusion during thrombolytic therapy in acute myocardial infarction. Am J Cardiol 1988;61: Chiladakis JA, Vlachos N, Patsouras N, Mazarakis A, Manolis AS. Usefulness of reperfusion ventricular arrhythmias in non-invasive prediction of early reperfusion and sustained coronary artery patency in acute myocardial infarction. J Thromb Thrombolysis. 2001;12: Bonnemeier H, Ortak J, Wiegand UK, Eberhardt F, Bode F, Schunkert H, Katus HA, Richardt G. Accelerated idioventricular rhythm in the post-thrombolytic era: incidence, prognostic implications, and modulating mechanisms after direct percutaneous coronary intervention Noninvasive Electrocardiol. 2005;10: Ferrier GR, Moffat MP, Lukas A. Possible mechanisms of ventricular arrhythmias elicited by ischemia followed by reperfusion. Circ Res 1985;56: Brugada R, Brugada P, Brugada J. Electrocardiogram interpretation and class I blocker challenge in Brugada syndrome. J Electrocardiol. 2006;39(4 Suppl):S Wilde AAM. Proarrhythmia related to sodium channel blockade: mechanisms, monitoring, prevention and management. Card Electrophysiol Rev 1998;2: Rolf S, Bruns H-J, Wichter T, et al. The ajmaline challenge in Brugada syndrome: diagnostic impact, safety, and recommended protocol. Eur Heart J 2003;24: Sosunov EA, Kostin IaV, Balashov VP. Effect of N-propylajmaline bromide on the normal and abnormal automatism of Purkinje fibers in the dog. Kardiologiia. 1990;30: Kirchhof PF, Fabritz CL, Franz MR. Postrepolarization refractoriness versus conduction slowing caused by class I antiarrhythmic drugs: antiarrhythmic and proarrhythmic effects. Circulation. 1998;97:
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