Surgical Management of TOF in Adults. Dr Flora Tsang Associate Consultant Department of Cardiothoracic Surgery Queen Mary Hospital
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1 Surgical Management of TOF in Adults Dr Flora Tsang Associate Consultant Department of Cardiothoracic Surgery Queen Mary Hospital
2 Tetralogy of Fallot (TOF) in Adults Most common cyanotic congenital heart disease which survival to adulthood is possible TOF in adults Non-repaired TOF in adults Repaired TOF with residual lesions Survival without surgery (non-repaired) 66% survive up to 1 yr, 49% survive up to 3 yrs, 24% survive to 10 years Betranou EG, Kirklin JW et al. Am J Cardiol 1978;42:458-66
3 Tetralogy of Fallot (TOF) in Adults Current trend - total correction as early as possible TOF in adults problems encountered Unrepaired Effects of prolonged cyanosis Polycythaemia, coagulation defects, development of eg bronchial collaterals => haemoptysis, secondary myocardial dysfunction Aortic root dilatation Biventricular failure
4 Tetralogy of Fallot (TOF) in Adults TOF in adults problems encountered Repaired Morphological or physiological consequences of previous palliative shunts Residual lesions eg chronic pulmonary regurgitation (transannular patch) & chronic pulmonary stenosis Aortic root dilatation Biventricular failure
5 Difficulties encountered during surgery Bleeding collaterals, re-sternotomy Reoperation Possibility of extensive adhesions in the pericardial cavity after previous operation Injury to the heart/great vessels upon sternal re-entry Need to control previous shunts before bypass Presence of collaterals/coronary fistula Shunting away of blood causing low perfusion pressure Difficulty in arresting the heart
6 Types of operations Total correction of TOF Closure of VSD, relief of RVOT obstruction +/- pulmonary valve replacement +/- takedown of previous shunts Pulmonary valve replacement (PVR) +/- RVOT reconstruction Aortic root replacement Heart transplantation
7 Types of operations Total correction of TOF Closure of VSD, relief of RVOT obstruction +/- pulmonary valve replacement +/- takedown of previous shunts Pulmonary valve replacement (PVR) +/- RVOT reconstruction Aortic root replacement Heart transplantation
8 Pulmonary valve replacement (PVR) Tetralogy of Fallot (TOF) corrective surgery Relief of right ventricular outflow tract (RVOT) obstruction Transannular incision
9 PVR Chronic PR is a common problem after congenital heart surgery esp after TOF repair Chronic PR is strongly associated with late adverse events RV dilatation, arrhythmia eg VT, sudden death Indications for PVR is really a balance between the risks of PVR surgery vs the benefits
10 PVR PVR does not improve survival & does not decrease the incidence of VT PVR improves symptoms, subjective exercise tolerance & functional class PVR reduces RV size in some patients Gengsakul A et al. Eur J Cardiothoracic Surg 2007;32: Harrild DM et al. Circulation 2009;119: Discigil B et al. J Thorac Cardiovasc Surg 2001;121: Frigiola A et al. Circulation 2008;118(suppl 14):S182-S190 Eyskens B et al. Am J Cardiol 2000;85: Tsang FH et al. Hong Kong Med J 2010;16:26-30
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13 Jan 2002 to Dec patients Our experience 1 patient has dysplastic pulmonary valve with severe PR All other patients have previous TOF repair
14 Results Time interval between TOF and PVR (years) / Pre-operative cardiothoracic ratio / Pre-operative QRS duration (ms) / Patients with pre-operative QRS > 180ms 15 (23.44%) Cardiopulmonary bypass time (mins) / Aortic cross-clamp time (mins) / Beating heart surgery 18 (28.1%) Hospital stay (days) /- 4.88
15 Post-PVR improvement Pre-PVR Post-PVR P QRS interval (ms) / / Cardiothoracic ratio / / < RV end-diastolic volume index (ml/m 2 ) / / <0.001 RV end-systolic volume index (ml/m 2 ) / / <0.001 RV ejection fraction (%) / / VO 2 max (ml) / /
16 1 mortality (1.5%) Our experience 1 patient with bleeding requiring exploration (1.5%) No other complications requiring surgical intervention Surgical PVR is a safe and effective way to correct chronic PR as a result of previous TOF repair
17 Summary TOF is the most common cyanotic congenital heart disease which survival to adulthood is possible Repaired vs unrepaired PVR common surgical intervention required in adulthood after previous TOF repair Surgical PVR is a safe and effective procedure to correct chronic PR as a result of previous TOF repair
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