Supplementary Figure 1. Implants derived from human embryoid body preparations contain non-cardiac structures. In early studies, infarcted hearts
|
|
- Clemence Walker
- 6 years ago
- Views:
Transcription
1 a Supplementary Figure 1. Implants derived from human emryoid ody preparations ontain non-ardia strutures. In early studies, infarted hearts reeived ell preparations of low ardia purity (<20% ardiomyoytes), otained y Peroll enrihment of spontaneously differentiating emryoid ody outgrowths. Most reipients of this ruder ell preparation, delivered without the pro-survival oktail, showed no surviving graft ells y four weeks posttransplantation. However, a suset of hearts (6 of 34) did show small human grafts within the infart sar that ontained oth ardia and non-ardia elements. Panel a shows a representative field from one suh heart after in situ hyridization with the human-speifi panentromeri proe (rown hromagen indiates human nulei). Although this graft did ontain small lumps of myoardium (see Panel, whih shows an adjaent setion that has een immunostained with a β-myosin heavy hain antiody, rown hromagen), it was largely omprised of non-ardia tissue elements, inluding disorganized vessels and rare epitheliumlined ysts (see Panel, immunostained with a pan-ytokeratins antiody, rown). Note that immunostains in panels & were performed on adjaent setions to that shown in panel a, and the fields depited orrespond to the upper and lower oxed areas in panel a. Sale ar = 20 mirons.
2 Supplementary Figure 2. Effiient ardiogenesis via direted differentiation. As is illustrated y this example, serial treatment of hescs with ativin A and BMP-4 results in preparations with extensive ardia differentiation. With eah grafting experiment, a small suset of the Peroll-enrihed ells to e implanted were ultured, fixed, and immunostained for β-myosin heavy hain (rown). Panels depit suh a preparation using ells ultured prior to (left) and following (right) enrihment y Peroll gradient entrifugation. Numers indiate the perentage of β-myosin heavy hain positive ells in the depited ell preparation.
3 a d Supplementary Figure 3. Proliferation of human myoardial implants. To determine whether the graft ardiomyoytes ontinue to proliferate in vivo, engrafted animals were pulsed with the thymidine analogue BrdU one hour prior to sarifie. Panel a shows a representative luster of β-myosin heavy hain positive (red hromagen) graft ardiomyoytes, a suset of whih show inorporation of BrdU (rown nulear signal, see lower oxed area and magnified image in panel ). Overall, a mean of 1.4± 0.2% of the graft ells were doule-positive for β- myosin heavy hain and BrdU. Futhermore, oasional graft ardiomyoytes showed mitoti figures (note oxed area in the upper right-hand orner and magnified image in panel ). Together, this evidene demonstrates sustained ell yle ativity as late as four weeks after transplantation into the infarted heart. Panel d shows a β-myosin heavy hain positive graft that inludes two human ardiomyoytes in mitosis (arrows). Sale ars = 25 mirons.
4 Supplementary Information Supplementary Figure 4. Host mirovasulature within human ardia implants. The human ardia implants ontained numerous mirovessels lined y host-derived endothelial ells. This representative field, whih ontains oth host and graft myoardium, has een immunostained with the rat-speifi endothelial ell marker, RECA-1 (rown). By ontrast, human, graft-derived endothelial ells (identified with a human-speifi antiody against CD31/PECAM and Ulex europaeus) were rare and infrequently formed vasular strutures (data not shown). Sale ar = 100 mirons.
5 Supplementary Figure 5. M-Mode ehoardiograms. Upper panel. Representative ontrol heart reeiving PSC-only. The left ventriular avity is dilated and the anterior wall shows akinesis. Left arrow indiates left ventriular end-systoli dimension (LVESD); right arrow indiates left ventriular end-diastoli dimension (LVEDD). Vertial sale ar = 5 mm; horizontal sale ar = 250 mse. Lower panel. Representative heart reeiving hesc-derived ardiomyoytes in PSC (Cells+PSC). There is redued left ventriular dilation relative to the aove PSC-only ontrol. The anterior wall moves inward during systole, indiating preservation of wall motion. Left arrow indiates left ventriular end-systoli dimension (LVESD); right arrow indiates left ventriular end-diastoli dimension (LVEDD). Vertial sale ar = 5 mm; horizontal sale ar = 250 mse.
6 Supplementary Tale 1. Histologi, ehoardiographi, and MRI parameters. Parameter Cardios + PSC PSC-Only SFM-Only Non-ardia ells Non-infarted Histologi Infart area (% LV area) 10.6 ± ± ± ± 1.5 N/A Ehoardiographi LVEDD, 48 hours (mm) 6.9 ± ± ± ± ± 0.1 LVESD, 48 hours (mm) 4.8 ± ± ± ± ± 0.1 Frational shortening, 48 hours (%) 28.1 ± ± ± ± ± 1 Heart rate, 48 hours (pm) 394 ± ± ± ± ± 12 LVEDD, 4 weeks (mm) 8.2 ± 0.2, # 9.2 ± 0.3, # 9.2 ± 0.2, # 9.1 ± 0.4, # 6.7 ± 0.1 LVESD, 4 weeks (mm) 5.8 ± 0.2, # 7.7 ± 0.3, #, ** 8.0 ± 0.1, #, ** 7.3 ± 0.5, #, ** 3.9 ± 0.2 Frational shortening, 4 weeks (%) 28.1 ± ± 1.7, #, ** 13.4 ± 1.3, #, ** 20.2 ± 3.5, #, ** 42 ± 1 Heart rate, 4 weeks (pm) ± 5.8, # ± 6.4, # ± 8.1,#,* ± ± 12 MRI (4 weeks) LVEDV (mm 3 ) 593 ± ± ± 27* 600 ± ± 26 ** LVESV (mm 3 ) 303 ± ± ± 28* 354 ± ± 9 ** LVEF (%) 50.3 ± ± 1.6 ^ 42.0 ± 1.9 ^^ 43.0 ± ± 1 ** Infart wall thikening (%) 27.5 ± ± 1.9 ** 8.8 ± 1.7 ** 9.8 ± 2.0 ** N/A Mid-septal wall thikening (%) 54.5 ± ± ± ± ± 2 Areviations: PSC pro-survival oktail, SFM serum-free medium, MRI magneti resonane imaging, LV left ventrile, LVEDD left ventriular end-diastoli dimension, LVESD left ventriular end-systoli dimension, LVEDV left ventriular end diastoli volume, LVESV left ventriular end systoli volume, LVEF left ventriular ejetion fration. # : signifiant differene versus paired 48 hr time point with p < * : signifiant differene from Cardios + PSC at same time point with p < ** : signifiant differene from Cardios + PSC at same time point with p < ^: orderline signifiane with p = 0.05 y ANOVA. Post ho analysis indiated signifiant differene vs Cardios +PSC (^: p< 0.05; ^^: p < 0.01)
Mark J Monaghan. Imaging techniques ROLE OF REAL TIME 3D ECHOCARDIOGRAPHY IN EVALUATING THE LEFT VENTRICLE TIME 3D ECHO TECHNOLOGY
Take the online multiple hoie questions assoiated with this artile (see page 130) Correspondene to: Dr Mark J Monaghan, Department of Cardiology, King s College Hospital, Denmark Hill, London SE5 9RS,
More informationSpleen VAT FMO. Nature Immunology: doi: /ni Ki67 DX5 CD27. CD11b 2B4 KLRG1 CD69 NKG2D CXCR3 CD44 NKG2A/C/E CD62L CD103 CD94 CD48.
IFN (% of ells) CD7 Marophages Medium NCR LPS PMA/Ionomyin CD IFN (% of ells) T ells Marophages B ells DX CD9 KLRG NKGD B CDL CD CD CXCR CD9 CD NKGA/C/E NCR Ly9h Ly9G Ly9d Ly9i Ly9/i/h FMO CD7 CD9a CD7
More informationSupplementary Information
Supplementary Information Optial ontrolling reveals time-dependent roles for adult-orn dentate granule ells Yan Gu, Maithe Arruda-Carvalho 3,4, Jia Wang, Stephen Janoshka,, Sheena Josselyn 3-5, Paul Frankland
More informationQuantitative Determination of Regional Left Ventricular Wall Dynamics by Roentgen Videometry
Quantitative Determination of Regional Left Ventriular Wall Dynamis by Roentgen Videometry By JEAN G. DumESNIL, M. D., ERIK L. RITMAN, MB., PH. D., ROBERT L. FRYE, M.D., GERALD T. GAU, M. D., BARRY D.
More informationRho-kinase Regulates Energy Balance by Targeting Hypothalamic Leptin Receptor Signaling
Rho-kinase Regulates Energy Balane y Targeting Hypothalami Leptin Reeptor Signaling Hu Huang 1, Dong Kong 1, Kyung Hee Byun 2, Chianping Ye 1, Shuihi Koda 1, Dae Ho Lee 1, Byung-Chul Oh 2, Sam W Lee 3,
More informationCyclic Fluctuations of the Alveolar Carbon Dioxide Tension during the Normal Menstrual Cycle
Cyli Flutuations of the Alveolar Carbon Dioxide Tension during the Normal Menstrual Cyle Ruth L. Goodland, M.S., and W. T. Pommerenke, Ph.D., M.D. THE SHORT spa~ of funtional life of the unfertilized human
More informationSupplementary Figure 1. Verification of drug infusions into the IPN. a. Representative
Supplementary Figure 1. Verifiation of drug infusions into the IPN. a. Representative neutral red-stained oronal setion from a mouse with a guide annula targeting the IPN. The guide annula sar is irled
More informationNico R Mollet, Filippo Cademartiri, Pim J de Feyter
BASICS See end of artile for authors affiliations Correspondene to: Pim J de Feyter, MD, PhD, Erasmus Medial Center, Department of Cardiology and Radiology, Thoraxenter Bd 410, PO Box 2040, 3000 CA Rotterdam,
More informationArterial pressure changes on cardiac function during hemodialysis
2 Arterial pressure hanges on ardia funtion during hemodialysis Dimitrios I. Chaniotis *, Evangelos Papademitriou, Stavroula Galani- Triantaphyllidou, Petros Petropoulos, Frangiskos Chaniotis Tehnologial
More informationMR Imaging of the Optic Nerve and Sheath: Correcting
249 MR Imaging of the Opti Nerve and Sheath: Correting the Chemial Shift Misregistration Effet David L. Daniels 1 J. rue Kneeland 1 nn Shimakawa 2 Kathleen W. Pojunas 1 John F. Shenk 3 Howard Hart, Jr.3
More informationCytomegalovirus and tumor stress-surveillance by human γδ T cell receptor binding to Endothelial Protein C Receptor
Cytomegalovirus and tumor stress-surveillane y human γδ T ell reeptor inding to Endothelial Protein C Reeptor Carrie R. Willox, Vinent Pitard, Sonia Netzer, Lionel Couzi, Mahoo Salim, Toias Silerzahn,
More informationa b Pml F/F Prrx1-cre f 1.4 n.s.
a b Pml F/F Prrx1-re X Prrx1-re-Pml F/F Relative CFU-F numbers 2. Prrx1-Cre-PML +/+ n.s. d early passages e f 1.4 n.s. Adsorbane Adsorbane.8.6.4.2.8.6.4.2 1 2 3 4 days in ulture late passages 2 4 6 8 1
More informationThomas Kahan, Lennart Bergfeldt
250 Cardiomyopathy LEFT VENTRICULAR HYPERTROPHY IN HYPERTENSION: ITS ARRHYTHMOGENIC POTENTIAL DEVELOPMENT See end of artile for authors affiliations Correspondene to: Professor Lennart Bergfeldt, Department
More informationHypertension is one the earliest recorded medical conditions (Nei Jin by Huang Ti around
1104 * NORMAL See end of artile for authors affiliations Correspondene to: Professor Alun Hughes, International Centre for Cirulatory Health, 10th Floor, QEQM Wing, St Mary s Hospital and Imperial College,
More informationRecuperative Potential of Cardiac Muscle following Relief of Pressure Overload Hypertrophy and Right Ventricular Failure in the Cat
RECUPERATIVE POTENTIAL IN HYPERTROPHY AND FAILURE/Coulson et al. 41 trolyte balane, and aldosterone and ortisol seretion in normal man and in irrhosis with asites. J Clin Invest 44: 1171-1186, 1965 28.
More informationChristian Seiler. Valve disease MANAGEMENT AND FOLLOW UP OF PROSTHETIC HEART VALVES OF PATIENTS WITH PROSTHETIC VALVES
818 Valve disease MANAGEMENT AND FOLLOW UP OF PROSTHETIC HEART VALVES MANAGEMENT Correspondene to: Professor Christian Seiler, University Hospital, Swiss Cardiovasular Center Bern, Freiburgstrasse, CH-3010
More informationAcute transcriptional up-regulation specific to osteoblasts/osteoclasts in medaka fish
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 Aute transriptional up-regulation speifi to osteoblasts/osteolasts in medaka fish immediately after exposure to mirogravity Masahiro Chatani, 1, Hiroya Morimoto,
More informationPrevalence of atrial fibrillation in the general population and in high-risk groups: the ECHOES study
Europae (2012) 14, 1553 1559 doi:10.1093/europae/eus087 CLINICAL RESEARCH Atrial fibrillation Prevalene of atrial fibrillation in the general population and in high-risk groups: the ECHOES study Russell
More informationThe Obesity Susceptibility Gene Carboxypeptidase E Links FoxO1 Signaling in Hypothalamic Pro opiomelanocortin Neurons with Regulation of Food Intake
Plum et al., Supplementary online material The Oesity Suseptiility Gene Caroxypeptidase E Links FoxO1 Signaling in Hypothalami Pro opiomelanoortin Neurons with Regulation of Food Intake Leona Plum, Hua
More informationMR of the Diaphragma Sellae
765 MR of the Diaphragma Sellae David L. Daniels 1 Kathleen W. Pojunas 1 David P. Kilgore 1 Peter Peh 2 Glenn. Meyer lan L. Williams 1 Vitor M. Haughton 1 The appearane of the diaphragma sellae is desribed
More informationStefan D Anker, Stephan von Haehling
464 See end of artile for authors affiliations Correspondene to: Dr Stefan D Anker, National Heart and Lung Institute, Department of Clinial Cardiology, Dovehouse Street, London SW3 6LY, UK; s.anker@imperial.a.uk
More informationEffect of Afterload on Force-Velocity Relations and Contractile Element Work in the Intact Dog Heart
Effet of fterload on Fore-Veloity Relations and ontratile Element Work in the ntat Dog Heart By Herbert J. Levine, M.D., Stanley. Forwand, M.D., Kevin M. Mlntyre, M.D., and Eliot Shehter, M.D. n the past
More informationRelative Attenuation of Sympathetic Drive During Exercise in Patients With Congestive Heart Failure
832 lacc Vol. 5, No.4 April!985:832-9 Relative Attenuation of Sympatheti Drive During Exerise in Patients With Congestive Heart Failure GARY S. FRANCIS, MD, FACC, STEVEN R. GOLDSMITH, MD, FACC, SUSAN ZIESCHE,
More informationSupplementary Figure 1. Schematic illustrating major conclusions of this study.
ORNs GABA A GABA B glomeruli LN PNs Supplementary Figure 1. Shemati illustrating major onlusions of this study. This study represents the most diret evidene to date of inhiitory interations etween olfatory
More informationSupplementary Figure 1 - Weiner
Supplementary Figure - Weiner Figure : Bioinformatis pipeline. Sequening of samples was performed on oth the Rohe 454 GS FLX+ instrument and the Illumina MiSeq instrument. Raw reads from 454 sequening
More informationMeasurement of Dose Rate Dependence of Radiation Induced Damage to the Current Gain in Bipolar Transistors 1
Measurement of Dose Rate Dependene of Radiation Indued Damage to the Current Gain in Bipolar Transistors 1 D. Dorfan, T. Dubbs, A. A. Grillo, W. Rowe, H. F.-W. Sadrozinski, A. Seiden, E. Spener, S. Stromberg,
More informationMANAGEMENT OF HYPERTENSION IN ETHNIC MINORITIES
Hypertension MANAGEMENT OF HYPERTENSION IN ETHNIC MINORITIES Take the online multiple hoie questions assoiated with this artile (see page 1104) CONSEQUENCES See end of artile for authors affiliations Correspondene
More informationCaroline P D Wheeler-Jones
1366 Take the online multiple hoie questions assoiated with this artile (see page 1374) T Basi siene CELL SIGNALLING IN THE CARDIOVASCULAR SYSTEM: AN OVERVIEW Caroline P D Wheeler-Jones Heart 2005; 91:1366
More information% of Nestin-EGFP (+) cells
8 7 6 3 Nestin CD % of Nestin-EGFP (+) ells 8 6 Nestin-EGFP Marge Nestin-EGFP Marge Expression levels of Expression levels of Tumorigeniity y stemness markers ifferentiation markers limiting ilution assay
More informationA 90-Day Chloroform Inhalation Study in F-344 Rats: Profile of Toxicity and Relevance to Cancer Studies
FUNDAMENTAL AND APPLIED TOXICOLOGY 32, 109-125 (1996) ARTICLE NO. 0113 A 90-Day Chloroform Inhalation Study in F-344 Rats: Profile of Toxiity and Relevane to Caner Studies MICHAEL V. TEMPLIN, JEFFREY L.
More informationAlpha-Adrenergic Receptors in Rat Myocardium
Alpha-Adrenergi Reeptors in Rat Myoardium Identifiation by Binding of [ 3 H]Dihydroergoryptine 721 R. SANDERS WILLIAMS AND ROBERT J. LEFKOWITZ SUMMARY [ 3 H]Dihydroergoryptine ([ 3 H]DHE) binds to sites
More informationSequence of epicardial repolarisation and
Br Heart J 1988;6:424-33 Sequene of epiardial repolarisation and onfiguration of the T wave J CAMPBELL COWAN, COLIN J HILTON, CLIVE J GRIFFITHS, SUDA TANSUPHASWADIKUL, JOHN P BOURKE, ALAN MURRAY, RONALD
More informationData Retrieval Methods by Using Data Discovery and Query Builder and Life Sciences System
Appendix E1 Data Retrieval Methods by Using Data Disovery and Query Builder and Life Sienes System All demographi and linial data were retrieved from our institutional eletroni medial reord databases by
More informationMiles Fisher. Coronary disease DIABETES AND ATHEROGENESIS RESISTANCE AND THE METABOLIC SYNDROME
336 Correspondene to: Dr Miles Fisher, Wards 4 & 5, Glasgow Royal Infirmary, Glasgow, G4 0SF, UK; miles.fisher@northglasgow. sot.nhs.uk Coronary disease DIABETES AND ATHEROGENESIS INSULIN T Miles Fisher
More informationJ D Schuijf, L J Shaw, W Wijns, H J Lamb, D Poldermans, A de Roos, E E van der Wall, J J Bax
1110 Imaging tehniques CARDIAC IMAGING IN CORONARY ARTERY DISEASE: DIFFERING MODALITIES Take the online multiple hoie questions assoiated with this artile (see page 1104) FUNCTIONAL See end of artile for
More informationLV geometric and functional changes in VHD: How to assess? Mi-Seung Shin M.D., Ph.D. Gachon University Gil Hospital
LV geometric and functional changes in VHD: How to assess? Mi-Seung Shin M.D., Ph.D. Gachon University Gil Hospital LV inflow across MV LV LV outflow across AV LV LV geometric changes Pressure overload
More informationKeywords: congested heart failure,cardiomyopathy-targeted areas, Beck Depression Inventory, psychological distress. INTRODUCTION:
International Journal of Medial Siene and Eduation An offiial Publiation of Assoiation for Sientifi and Medial Eduation (ASME) Original Researh Artile ASSOCIATION BETWEEN QUALITY OF LIFE AND ANXIETY, DEPRESSION,
More informationAndrew Murday SURGERY OPTIMAL MANAGEMENT OF ACUTE VENTRICULAR SEPTAL RUPTURE. c PATHOLOGY
1462 SURGERY OPTIMAL MANAGEMENT OF ACUTE VENTRICULAR SEPTAL RUPTURE Correspondene to: Mr Andrew Murday, Glasgow Royal Infirmary, Alexandra Parade, Glasgow, G31 2ER, UK; andrew.murday@ btinternet.om E Andrew
More informationInfluenza affects elderly patients
INFORMATION FOR THE PHARMACIST This artile was sponsored y Seqirus In. FLUAD (influenza vaine, adjuvanted) to Help Protet Elderly Patients Against Influenza Influenza affets elderly patients disproportionately,
More informationTHE ATP-DEPENDENT CONCENTRATION OF CALCIUM BY A GOLGI APPARATUS-RICH FRACTION ISOLATED FROM RAT LIVER
J. Cell Si. 30, 117-128 (1978) Printed in Great Britain Company of Biologists Limited igys THE ATP-DEPENDENT CONCENTRATION OF CALCIUM BY A GOLGI APPARATUS-RICH FRACTION ISOLATED FROM RAT LIVER STUART HODSON
More informationHeart in Diabetes: Not Only a Macrovascular Disease
D I A B E T E S & C A R D I O V A S C U L A R D I S E A S E Heart in Diabetes: Not Only a Marovasular Disease BERND STRATMANN, PHD DIETHELM TSCHOEPE, MD EPIDEMIOLOGY The importane of diabetes as a ause
More informationMETHODS JULIO A. PANZA, MD, ARSHED A. QUYYUMI, MD, JEAN G. DIODATI, MD, TIMOTHY S. CALLAHAN, MS, STEPHEN E. EPSTEIN, MD, FACC
JACC Vol. 17. No.3 Marh 1. 1991 :657-63 657 METHODS Predition of the Frequeny and Duration of Ambulatory Myoardial Ishemia in Patients With Stable Coronary Artery Disease by Determination of the Ishemi
More informationRebecca E Lane, Martin R Cowie, Anthony W C Chow
674 Take the online multiple hoie questions assoiated with this artile (see page 695) See end of artile for authors affiliations Correspondene to: Dr Anthony W C Chow, The Heart Hospital, UCLH NHS Trust,
More informationDetection and Classification of Brain Tumor in MRI Images
PrahiGadpayle and Prof.P.S.Mahajani 45 Detetion and Classifiation of Brain Tumor in MRI Images PrahiGadpayleand Prof.P.S.Mahajani Abstrat Brain tumor detetion in Magneti Resonane Imaging (MRI) is important
More informationProliferation of Legionella pneumophila as an Intracellular Parasite
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, Mar. 1984, p. 467-471 0099-2240/84/030467-05$02.00/0 Copyright C) 1984, Amerian Soiety for Mirobiology Vol. 47, No. 3 Proliferation of Legionella pneumophila as
More informationHeart failure CLINICAL USEFULNESS OF B-TYPE NATRIURETIC PEPTIDE MEASUREMENT: PRESENT AND FUTURE PERSPECTIVES
Heart failure CLINICAL USEFULNESS OF B-TYPE NATRIURETIC PEPTIDE MEASUREMENT: PRESENT AND FUTURE PERSPECTIVES Take the online multiple hoie questions assoiated with this artile (see page 1488) EFFECTS Correspondene
More information100 osimertinib. concentration of drugs (nm) Ba/F3 C797S/del19. concentration of drugs (nm) Ba/F3 C797S/T790M/L858R. relative cell vaibility (% of
Ba/F3 del19 Ba/F3 L858R a afatini afatini EGF-816 EGF-816 ty (% of ontrol) relative ell vaiilit elative ell vaiility (% of ontrol) 5 1 1 5 ty (% of ontrol) relative ell vaiilit 5 1 1 Ba/F3 T79M/L858R Ba/F3
More informationThe use of the implantable cardioverter-defibrillator (ICD) for life threatening ventricular
488 * Eletrophysiology QUALITY OF LIFE AND PSYCHOLOGICAL FUNCTIONING OF ICD PATIENTS QUALITY Correspondene to: Samuel F Sears Jr, PhD, University of Florida, Department of Clinial & Health Psyhology, Box
More informationLearned spatiotemporal sequence recognition and prediction in primary visual cortex
Supplementary Materials for Learned spatiotemporal sequene reognition and predition in primary visual ortex Jeffrey P. Gavornik and Mark F. Bear Howard Hughes Medial Institute Piower Institute for Learning
More informationWT;ATTAC-5 ** ** SkM
SUPPLEMENTARY INFORMATION doi:.3/nature a WT;ATTAC- H/H;ATTAC- WT;ATTAC- H/H;ATTAC- 3 weeks months GFP p Inka relative expression 3 SkM Skel. Mus. FKBP- relative expression SkM Skel. Mus. relative expression
More informationLuc A Piérard, Patrizio Lancellotti
Valve disease STRESS TESTING IN VALVE DISEASE Lu A Piérard, Patrizio Lanellotti 766 Take the online multiple hoie questions assoiated with this artile (see page 765) AORTIC S Heart 2007; 93:766 772. doi:
More informationSequence Analysis using Logic Regression
Geneti Epidemiology (Suppl ): S66 S6 (00) Sequene Analysis using Logi Regression Charles Kooperberg Ingo Ruzinski, Mihael L. LeBlan, and Li Hsu Division of Publi Health Sienes, Fred Huthinson Caner Researh
More informationRoad Map to a Delirium Detection, Prevention and Management Program
Road Map to a Delirium Detetion, Prevention and Management Program Delirium Prevention 2014 Minnesota Hospital Assoiation The Road Map to a Delirium Detetion, Prevention, and Management Program provides
More informationCARDIOVASCULAR EFFECTS OF A NEW INOTROPIC AGENT, U.K , IN PATIENTS WITH CORONARY HEART DISEASE
Br. J. lin. Pharma. (1977), 4, 513-517 CRDOVSCULR FFCTS OF W OTROPC GT, U.K. 14275, PTTS WTH CORORY HRT DSS 1. HUTTO, W.S. HLLS, C.. LGH, J.M. COLY & T.D.V. LWR University of Glasgow Department of Medial
More informationDefective neutrophil function in low-birth-weight,
J Clin Pathol 1981 ;34:366-37 Defetive neutrophil funtion in low-birth-weight, premature infants H AL-HADITHY, IE ADDISON, AH GOLDSTONE, JC CAWLEY, AND JC SHAW From the Departments of Haematology and Paediatris,
More informationmagnesium sulphate on cardiac rhythm in acute
Br Heartj 1994;71:141-145 Department of Pharmaology and Therapeutis, University of Leiester C Roffe S Flether KLWoods Correspondene to: Dr Kent L Woods, Department of Pharmaology and Therapeutis, Clinial
More informationAntiarrhythmic actions of verapamil against ischaemic arrhythmias in the rat
Br. J. Pharma. (1984), 83,373-385 Antiarrhythmi ations of verapamil against ishaemi arrhythmias in the rat M.J. Curtis, B.A. MaLeod & M.J.A. Walker Department of Pharmaology & Therapeutis, Faulty of Mediine,
More informationAn Intelligent Decision Support System for the Treatment of Patients Receiving Ventricular Assist Device Support
Original Artiles 1 An Intelligent Deision Support System for the Treatment of Patients Reeiving Ventriular Assist Devie Support E. C. Karvounis 1,2 ; M. G. Tsipouras 1,2 ; A. T. Tzallas 1,2 ; N. S. Katertsidis
More informationReversal of ammonia coma in rats by L-dopa: a peripheral effect
Gut, 1979, 2, 28-32 Reversal of ammonia oma in rats by L-dopa: a peripheral effet L. ZV1, W. M. DOZAK, AND R. F. DRR From the Department of Mediine, Hennepin ounty Medial enter and Minneapolis Veterans
More informationLumbar radiographs in anteroposterior (AP), lateral, and oblique
Diagn Interv Radiol 200; 15:1 1 Turkish Soiety of Radiology 200 MUSCULOSKELETAL IMAGING ORIGINAL ARTICLE Postoperative lumar spine: modified radiographi projetions for detetion of one defets in adavers
More informationpolymorphonuclear neutrophil release of granular
Br. J. Pharma. (1985), 86, 533-537 Phorbol myristate aetate enhanes human polymorphonulear neutrophil release of granular enzymes but inhibits hemokinesis J.R.S. Hoult & Sussan Nourshargh Department of
More informationRichard W Troughton, Craig R Asher, Allan L Klein
Imaging tehniques THEROLEOFECHOCARDIOGRAPHYIN ATRIAL FIBRILLATION AND CARDIOVERSION ATRIAL See end of artile for authors affiliations Correspondene to: Allan L Klein MD, Cleveland Clini Foundation, Department
More informationOF THE CORONARY COLLATERAL CIRCULATION
1352 RELEVANCE Correspondene to: Professor Christian Seiler, University Hospital, Swiss Cardiovasular Center Bern, Freiburgstrasse, CH-3010 Bern, Switzerland; hristian.seiler.ardio@ insel.h C CORONARY
More informationMicroRNA-494 promotes cancer progression and targets adenomatous polyposis coli in colorectal cancer
Zhang et al. Moleular Caner (8) 7: DOI.86/s94-7-75- RESEARCH Open Aess MiroRNA-494 promotes aner progression and targets adenomatous polyposis oli in oloretal aner Ying Zhang, Lu Guo,, Yuhuan Li,, Gui-Hai
More informationDonor shortage in heart transplantation
Donor shortage in heart transplantation Is extension of donor age limits justified? Chroni shortage of donor organs for heart transplantation led us to extend donor age limits. To verify the effetiveness
More informationD-4F Does Not Mitigate Key Parameters in Rat Model of Severe Pulmonary Hypertension
Marquette University e-publiations@marquette Biomedial Engineering Faulty Researh and Publiations Biomedial Engineering, Department of 8-1-2007 D-4F Does Not Mitigate Key Parameters in Rat Model of Severe
More informationSupplementary Information Computational Methods
Supplementary Information Computational Methods Data preproessing In this setion we desribe the preproessing steps taken to establish the data matrix of hepatoyte single ell gene expression data (Table
More informationA HEART CELL GROUP MODEL FOR THE IDENTIFICATION OF MYOCARDIAL ISCHEMIA
A HEART CELL GROUP MODEL FOR THE IDENTIFICATION OF MYOCARDIAL ISCHEMIA Mohamed A. Mneimneh, Miheal T. Johnson and Rihard J. Povinelli Eletrial and Computer Engineering, Marquette University, 55 Wisonsin
More informationFilippo Crea, Gaetano A Lanza
See end of artile for authors affiliations Correspondene to: Professor Filippo Crea, Istituto di Cardiologia, Università Cattolia del Saro Cuore, Largo A. Gemelli, 8, 00168 Roma, Italy; f.rea@tisalinet.it
More informationLarge Virchow-Robin Spaces:
929 Large Virhow-Robin Spaes: MR-Ciinial Correlation Linda A. Heier 1 Cristel J. Bauer 1 Larry Shwartz 1 Robert D. Zimmerman 1 Susan Morgello 2 Mihael D. F. Dek 1 High-field MR sans frequently show Virhow-Robin
More informationIMAGING IN MULTIPLE SCLEROSIS
See end of artile for authors affiliations Correspondene to: Professor David H Miller, NMR Researh Unit, Department of Neuroinflammation, Institute of Neurology, University College London, Queen Square,
More informationThe comparison of psychological evaluation between military aircraft noise and civil aircraft noise
The omparison of psyhologial evaluation between military airraft noise and ivil airraft noise Makoto MORINAGA ; Ippei YAMAMOTO ; Hidebumi TSUKIOKA ; Koihi MAKINO 2, Sonoko KUWANO 3, Mitsuo MATSUMOTO 4
More informationEffect of Dietary Astaxanthin and Background Color on Pigmentation and Growth of Red Cher r y Shr imp, Neocaridina heteropoda
KASETSART UNIVERSITY FISHERIES RESEARCH BULLETIN 04, VOLUME 38 () Effet of Dietary and Color on Pigmentation and Growth of Red Cher r y Shr imp, Neoaridina heteropoda Nongnuh Laohavisuti * and Usharee
More informationImpaired thermogenesis and adipose tissue development in mice with fat-specific disruption of insulin and IGF-1 signalling
Reeived 7 Fe 1 Aepted 14 May 1 Pulished 1 Jun 1 DOI: 1.138/nomms195 Impaired thermogenesis and adipose tissue development in mie with fat-speifi disruption of insulin and IGF-1 signalling Jeremie Bouher
More informationKeith A A Fox. Coronary disease MANAGEMENT OF ACUTE CORONARY SYNDROMES: AN UPDATE
698 ESTABLISHING Correspondene to: Professor Keith A A Fox, Cardiovasular Researh Unit, Centre for Cardiovasular Siene, University of Edinburgh, Chanellor s Building, 49 Little Frane Cresent, Edinburgh
More informationOF INTRACARDIAC ECHOCARDIOGRAPHY IN INTERVENTIONAL PROCEDURES
Imaging tehniques CLINICAL APPLICATIONS OF INTRACARDIAC ECHOCARDIOGRAPHY IN INTERVENTIONAL PROCEDURES Take the online multiple hoie questions assoiated with this artile (see page 990) BASICS See end of
More informationEffect of atorvastatin on inflammation and outcome in patients with type 2 diabetes mellitus on hemodialysis
http://www.kidney-international.org & 2008 International Soiety of Nephrology original artile Effet of atorvastatin on inflammation and outome in patients with type 2 diabetes mellitus on hemodialysis
More informationLiver allograft pathology: approach to interpretation of needle biopsies with clinicopathological correlation
Laboratory Mediine Program, University Health Network/ University of Toronto, Toronto, Ontario, Canada Correspondene to: Maha Guindi, Laboratory Mediine Program, University Health Network/University of
More informationAssessment of LV systolic function
Tutorial 5 - Assessment of LV systolic function Assessment of LV systolic function A knowledge of the LV systolic function is crucial in the undertanding of and management of unstable hemodynamics or a
More informationclinical conditions using a tape recorder system
Thorax (1964), 19, 125 Objetive assessment of ough suppressants under linial onditions using a tape reorder system C. R. WOOLF AND A. ROSENBERG From the Respiratory Unit, Sunnybrook Hospital (Department
More informationUbiquitin-dependent degradation of TGF-β-activated Smad2
Ubiquitin-dependent degradation of -ativated Roger S. Lo* and Joan Massagué* *Cell Biology Program, Howard Hughes Medial Institute, Memorial Sloan-Kettering Caner Center, New York, New York 10021, USA
More informationRegulation of spike timing in visual cortical circuits
Regulation of spike timing in visual ortial iruits Paul Tiesinga*, Jean-Mar Fellous and Terrene J. Sejnowski Abstrat A train of ation potentials (a spike train) an arry information in both the average
More informationMagnetic Resonance Imaging of the Cavernous Sinus
187 Magneti Resonane Imaging of the Cavernous Sinus David L. Daniels 1 Peter Peh Leighton Mark Kathleen Pojunas lan L. Williams Vitor M. Haughton The magneti resonane (MR) appearane of the avernous sinus
More informationHistological profile of tumours from MYCN transgenic mice
Histologial profile of tumours from MYCN transgeni mie H C Moore, 1 K M Wood, 2 M S Jakson, 3 M A Lastowska, 3 D Hall, 3 H Imrie, 1 C P F Redfern, 1 P E Lovat, 1 F Ponthan, 1 K O Toole, 1 J Lune, 1 D A
More informationSupplemental Table 1. Primers used for real-time quantitative RT-PCR assay. Nucleotide sequence
Supplemental Table 1. Primers used for real-time quantitative RT-PCR assay Name FoxO1 forward FoxO1 reverse GK forward GK reverse INS-1 forward INS-1 reverse INS-2 forward INS-2 reverse Glut2 forward Glut2
More informationMessenger RNA in HeLa Cells :
ur. J. Biohem. 17 (1970) 296-318 Messenger RNA in HeLa Cells : An nvestigation of Free and Polyribosome-Bound Cytoplasmi Messenger Ribonuleoprotein Partiles by Kineti Labelling and letron Mirosopy Georges
More informationCHOLINERGIC ACTION IN THE NUCLEUS ACCUMBENS: MODULATION OF DOPAMINE AND ACETYLCHOLINE RELEASE
Br. J. Pharma. (1982), 75, 359-365 CHOLINERGIC ACTION IN THE NUCLEUS ACCUMBENS: MODULATION OF DOPAMINE AND ACETYLCHOLINE RELEASE J.S. de BELLEROCHE & I.M. GARDINER Departments of Neurology and Biohemistry,
More informationa-4/b-1 and a-l/b-2 integrins mediate cytokine induced lung leukocyte-epithelial adhesion and injury
British Journal of Pharmaology (27) 152, 915 929 & 27 Nature Publishing Group All rights reserved 7 1188/7 $3. www.brjpharmaol.org RESEARCH PAPER a-4/b-1 and a-l/b-2 integrins mediate ytokine indued lung
More informationAlthough there is very little high quality evidence to guide the medical treatment of valve disease,
Valve disease THE MEDICAL MANAGEMENT OF VALVAR HEART DISEASE AORTIC Correspondene to: Dr NA Boon, Department of Cardiology, Royal Infirmary of Edinburgh, 1 Lauriston Plae Edinburgh EH3 9YW, UK; nik.boon@luht.sot.nhs.uk
More informationMR of Craniopharyngiomas:
439 MR of Craniopharyngiomas: Tumor Delineation and Charaterization Elizabeth Pusey' Keith E. Kortman 2 onnie D. Flannigan, 3 Jay Tsuruda 2 William G. radley2 MR imaging and CT (with and without ontrast
More informationEvaluation of a prototype for a reference platelet
932 Royal Postgraduate Medial Shool, Duane Road, London W12 ONN S M Lewis Western Infirmary, Glasgow R M Rowan Toa Medial Eletronis, Kobe, Japan F Kubota Correspondene to: Dr S M Lewis Aepted for publiation
More informationForm 4: Coronary Evaluation
Form : Coronary Evaluation Print this Form t Started Date of Coronary Evaluation Coronary Evaluation Indication for Coronary Evaluation Check only one. Angio NOT DONE: n invasive test performed Followup
More informationUrea and oxalate inhibition of the serum lactate dehydrogenase
and oxalate inhibition of the serum latate dehydrogenase PULINE M. EMERSON ND J. H. WILKINSON J. lin. Path. (1965), 18, 83 From the Department of Chemial Pathology, Westminster Medial Shool (University
More informationCase Report Duplication Cyst in the Third Part of the Duodenum Presenting with Gastric Outlet Obstruction and Severe Weight Loss
Case Reports in Surgery Volume 015, Artile ID 749085, 4 pages http://dx.doi.org/10.1155/015/749085 Case Report Dupliation Cyst in the Third Part of the Duodenum Presenting with Gastri Outlet Obstrution
More informationReading a Textbook Chapter
HENR.546x.APPBpp001-013 7/21/04 9:37 AM Page 1 APPENDIX B Reading a Textbook Chapter Copyright 2005 Pearson Eduation, In. 1 2 Read the following hapter from the ollege textbook Total Fitness: Exerise,
More informationcholerae Non-Ol and Comparison with a Protease of V. cholerae 01
INFECTION AND IMMUNITY, Sept. 1989, p. 2799-283 Vol. 57, No. 9 19-9567/89/92799-4$2./ Copyright C) 1989, Amerian Soiety for Mirobiology Purifiation and Charaterization of a Protease Produed by Vibrio holerae
More informationMike J L DeJongste, René A Tio, Robert D Foreman
See end of artile for authors affiliations Correspondene to: Dr Mike J L DeJongste, Department of Cardiology, Thoraxenter, University Hospital of Groningen, PO Box 30,001, 9700 RB Groningen, The Netherlands;
More information