HEART AND STROKE FOUNDATION RESEARCH REPORT

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1 HEART AND STROKE FOUNDATION RESEARCH REPORT

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3 Heart and Stroke Foundation Research Report MISSION The Heart and Stroke Foundation (HSF), a volunteer-based health charity, leads in eliminating heart disease and stroke and reducing their impact through the advancement of research and its application, the promotion of healthy living, and advocacy. Every seven minutes in Canada, someone dies from heart disease or stroke. Heart disease and stroke are two of the three leading causes of death in Canada; more than 50,000 strokes, an estimated 70,000 heart attacks, and up to 45,000 cardiac arrests occur every year. The Heart and Stroke Foundation has invested more than $1.3 billion in leading-edge heart and stroke research in the last 60 years. Since 1952, cardiovascular disease mortality has decreased more than 75% and over the past decade alone has decreased nearly 40%, thanks in large part to our research. Cover Photo: Dr. Todd Anderson (Foothills Hospital) is the Chair of the Heart and Stroke Foundation of Canada s Scientific Review Committee (). i

4 Heart and Stroke Foundation Research Report TABLE OF CONTENTS Message from the President... 1 ACKNOWLEDGEMENTS PURPOSE AND SCOPE SUMMARY TABLES RESEARCH FUNDING OVERVIEW Research Roles Scientific Review Process Research Enterprise Components Investments across Health Research Themes RESEARCH FUNDING BY PROGRAM Federation Research Fund National Personnel Awards Heart and Stroke Foundation Prestigious Awards Grant-in-Aid Province-specific Research Initiatives Research Chairs and Professorships Provincial Personnel Awards Other Provincial Initiatives TABLES Table 1. Summary Federation-wide and Province-specific Research Funding ()... 4 Table 2. Detailed Federation-wide and Province-specific Research Funding ()... 5 Table 3. Number of National Personnel Awards and Investment of Funds () Table 4. HSF National Personnel Awards by Health Research Theme () Table 5. Number of Grants-in-Aid and Investment of Funds () Table 6. Research Chairs and Professorships () Table 7. HSF Provincial Personnel Awards Funded () Table 8. Other Provincial Research Initiatives () FIGURES Figure 1. HSF Research Funding by Program ()... 7 Figure 2. HSF Research Funding Trends by Program (2006-)... 8 Figure 3. HSF Research Funding by Health Research Theme ()... 8 Figure 4. HSF Research Funding Trends by Health Research Theme (2006-)... 8 Figure 5. Federation Research Fund Leveraged Funding (2006-) Figure 6. Federation Research Fund Funding by Health Research Theme () Figure 7. Federation Research Fund Funding Trends by Health Research Theme (2006-) Figure 8. National Personnel Awards Funding by Health Research Theme () Figure 9. National Personnel Awards Funding Trends by Health Research Theme (2006-) Figure 10. Number of National Personnel Award Applications Submitted and Funded by Province/ Territory () Figure 11. grant-in-aid Funding by Health Research Theme () Figure 12. grant-in-aid Funding Trends by Health Research Theme (2006-) Figure 13. Number of Grant-in-Aid Applications Submitted by Province/Territory (2006-) Figure 14. Number of Grant-in-Aid Applications Funded by Province/Territory (2006-) ii

5 Heart and Stroke Foundation Research Report APPENDIX A: FEDERATION RESEARCH FUND NEW INITIATIVES Monitoring and Optimizing CPR Resuscitation and Knowledge Transfer Built Environment: Population Health Intervention Research Novel and Exploratory Research Fund Operating Grant: Population Health Intervention Research HSFC/PFC Scholarships in Physiotherapy Research CIHR/HSFC Training Awards in Population Intervention for Chronic Disease Prevention: A Pan-Canadian Program Jump Start Resuscitation Focus on Stroke CONTINUING INITIATIVES Research Programs Covert Stroke Clinical Imaging Team Grants Resuscitation Outcomes Consortium (ROC) Renewal Coalitions Linking Action and Science for Prevention (CLASP) Prevention of Cardiovascular and Respiratory Diseases Intervention Research (Healthy Living and Chronic Disease Prevention) Secondary Stroke Prevention Health Services and Care Team Grants Vascular Cognitive Impairment Applied Public Health Chair Childhood Obesity Prevention and Treatment Operating Grants Intervention Research (Healthy Living and Chronic Disease Prevention) Built Environment, Obesity and Health Cardiovascular Complications of Diabetes Reducing Health Disparities and Promoting Equity for Vulnerable Populations - Interdisciplinary Capacity Enhancement (ICE) Team Grants Genomic Medicine and Human Development Training Programs Focus on Stroke Focus on Stroke APPENDIX B: NATIONAL PERSONNEL AWARDS Doctoral Research Awards Research Fellowships Research Scholarships New Investigators Distinguished Clinician Scientist Industry-Supported Research Fellowship Awards APPENDIX C: GRANTS-IN-AID British Columbia/Yukon Alberta/Northwest Territories/Nunavut Saskatchewan Manitoba Ontario Quebec New Brunswick Nova Scotia Newfoundland and Labrador APPENDIX D: RESEARCH CHAIRS AND PROFESSORSHIPS APPENDIX E: PROVINCIAL PERSONNEL AWARDS Saskatchewan Manitoba Ontario Newfoundland and Labrador APPENDIX F: OTHER PROVINCIAL INITIATIVES Ontario Quebec Nova Scotia APPENDIX G: RESEARCH COMMITTEE MEMBERS APPENDIX H: DEFINITION OF HEALTH RESEARCH THEMES iii

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7 Heart and Stroke Foundation Research Report MESSAGE FROM THE PRESIDENT In, the Heart and Stroke Foundation spent over $51 million in research, funding almost 1,500 researchers in medical institutes, universities, hospitals, and communities across the country. Since 1956, this has totalled more than $1.3 billion in research support. Research funded by the Foundation continues to save and improve countless lives, revolutionize care, and profoundly deepen our understanding of heart and stroke health. In our 60 th anniversary year, the Foundation is building on this legacy with an ambitious new goal to reduce death from heart disease and stroke by 25 per cent by the year Why? Because every seven minutes in Canada, someone dies from heart disease or stroke. Over 1.6 million survivors and their families and caregivers are living with the devastating after-effects. They foster our commitment to health education, drives our research in prevention, treatment and rehabilitation, and shape our advocacy work. MORE HOURS IN A DAY. MORE DAYS IN A YEAR. MORE YEARS IN A LIFE. In, the Foundation reached a historic milestone. After decades of operating as a federation of provincial Foundations, we united to become one strong, national organization. In tandem, the first-ever comprehensive Foundation-wide research strategic plan, Reaching for Impact, was approved by the board after three years of development and consultation. This bold plan will sharpen our efforts to fund research that will have the greatest impact on our mission and the health of Canadians, while strategically linking research results to health policy and practice. It will spark collaboration, synergies, innovation, and leverage resources across the Organization and with a broad array of partners. INVESTING IN THE FUTURE Over the next five years, while 60 per cent of Heart and Stroke funding will be directed towards basic biomedical research, the percentage of funding that goes to clinical, health services/ systems and population health will increase by approximately 20 per cent so that it will account for 40 per cent of the research investment. This will support the Foundation s mission to capitalize on the important lab discoveries and continue to increase our impact against heart disease and stroke. At the same time, 60 percent of our funds will be dedicated to investigator-initiated research and the Foundation will increase strategic research by 20 per cent to account for 40 per cent of total annual research spending. With the plan, 80 per cent of HSF research funds will be managed as part of a national collective program, while 20 per cent of funds will be dedicated to provincial research priorities. Finally, we will maintain the existing balance of directing 10 per cent of our funds to research personnel awards and 90 per cent to be directed to project grants. The plan will be rolled out gradually over the next five years so that everyone has time to understand, adjust and thrive. ADDING HEALTHY, QUALITY YEARS TO LIFE I continue to be impressed by the quality, scope, and impact of our research including these initiatives: Investigator Comes up ACEs: Dr. Gavin Oudit is the 2010 recipient of two prestigious awards, the McDonald Scholarship the Heart and Stroke Foundation of Canada s top award for New Investigators and the HSFC Distinguished Clinician Scientist, which is presented in partnership with the CIHR Institute of Circulatory and Respiratory Health to the Foundation s highest-ranked clinician in the New Investigator competition. Dr. Oudit is studying the potential of the ACE2 molecule in preventing heart failure and improving the quality of life for patients with heart disease. Healthy communities, healthier Canadians:110 HSFC/ CIHR researchers, policy-makers, educators, and urban planners met at a national conference, Sharing Knowledge, Building Links Advancing Research, Policy, and Practice on the Built Environment, understood as the physical and social environment that is both affected by and itself affects urban policy, design, and development as well as liveable, walkable, and sustainable communities. The resulting action plan promises healthier communities. The rewards are huge: reduced levels of obesity, chronic diseases, and air pollution; increased physical activity; better food options; and healthier, happier citizens. Marvelling at the brain s complexity: HSFC Barnett Scholar Dr. Majid Heidari-Mohajerani is exploring how brain cells change their activity after stroke and impact re-organize to guide recovery. Discoveries could lead to the development of new tools to help the brain rewire itself following stroke, giving hope to stroke patients and reducing disability. From coast to coast, Heart and Stroke Foundation researchers like these are producing advances in knowledge at a rate not even dreamed of 60 years ago. Imagine the possibilities! Sincerely, Bobbe Wood, President Heart and Stroke Foundation of Canada 1

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9 Heart and Stroke Foundation Research Report ACKNOWLEDGEMENTS Each year, individuals across Canada join together to further the Heart and Stroke Foundation (HSF) mission of eliminating heart disease and stroke. Canadians from coast to coast donate valuable resources, including their time, money, and expertise, to improve the health and quality of life of all Canadians. The following groups deserve special thanks: Donors. Providing funds to support heart and stroke research is the first step in a process which culminates in scientific breakthroughs that touch all our lives. The donors and volunteers in every community across Canada that have supported the Foundation s fundraising efforts have made lasting investments in the future health and well being of Canadians. Research Advisory Committees. Expert and dedicated members of HSF advisory committees provide critical guidance for the Foundations research endeavour. In particular, the provincial Research Advisory Committees and the Research Policy and Planning Advisory Committee (a standing committee of the HSFC Board) have been instrumental in moving HSF research efforts forward. The Chairs of these important committees are listed in Appendix G (page 124). Scientific Review Committees. The scientific and lay reviewers expertise and commitment enable HSF to fund the highest standard of scientific excellence. Nationally, exemplary leadership to over 1,000 volunteer reviewers has been provided by the Scientific Review Committee s Chair and Vice Chair, Drs. Todd Anderson and Peter Backx, respectively. The Chairs of HSF s vital peer review committees across the Federation are identified in Appendix G (page 124). 1. PURPOSE AND SCOPE The purpose of this report is twofold: 1. To illustrate the Heart and Stroke Foundation s overall research investments made in across all research funding programs and initiatives. 2. To serve as a reference tool for volunteers and staff across the Heart and Stroke Foundation, the research community, other research funding agencies, and academic institutions. This report covers the period from July 1, 2010 to June 30,. It is a snapshot of expenditures in research during that period. The report presents financial and statistical data for new grants and awards made in, as well as continued funding of previously reported multi-year grants and awards. Heart and Stroke Researchers. Each one of HSF s researchers, through extraordinary work, contributes to advancements in the understanding of cardio- and cerebrovascular disease. The knowledge gained from their efforts leads to earlier diagnoses, better treatments and new insights into prevention. Their ongoing commitment to the advancement of knowledge helps HSF move closer to achieving its mission. Partners. A number of organizations collaborated with HSF in, enabling the Foundation to leverage funding and resources for heart and stroke research. 3

10 Heart and Stroke Foundation Research Report 2. SUMMARY TABLES Table 1. Summary Federation-wide and Province Specific Research Funding () Foundation Federation-wide Research Initiatives Province-specific Research Initiatives Total Grant-in-Aid National Personnel Awards Federation Research Fund Personnel Awards # $ # $ # $ # $ # $ # $ # $ British Columbia/ 33 2,883, , ,033,029 Yukon Alberta/Northwest 47 2,720, , ,039,725 Territories/Nunavut Saskatchewan , , ,000 Manitoba , , ,500 Ontario ,906, ,929, , ,331, ,373,431 Quebec 76 1,696, , ,814,333 New Brunswick 5 276, ,505 Nova Scotia , , , ,750 Prince Edward Island Newfoundland and 1 40, , ,000 Labrador All Foundations ,429,856 * 84 3,629, , ,488,421 TOTAL 450 $33,172, $4,429, $3,629, $3,993, $735, $5,913, $51,875,694 * Includes award stipends, obligatory benefits, and applicable travel and/or allowances. HSF contributions to the CSN total $3 million (2007-). Chairs Other 4

11 Heart and Stroke Foundation Research Report Table 2. Detailed Federation-wide and Province-specific Research Funding () Foundation Program Awards (#) Awards ($) Total ($) British Columbia/Yukon Grant-in-Aid 33 2,883,029 Research Chairs*: Chair in Cardiovascular Prevention Research 1 150,000 Chair in Stroke Research 1 0*** Professorship in Clinical Stroke Research 1 0*** 3,033,029 Alberta/ Grant-in-Aid 47 2,720,000 Northwest Territories/ Nunavut Research Chairs*: Chair in Cardiovascular Research 2 222,137 Chair in Stroke Research 1 37,588 Professorship in Stroke Research 1 60,000 3,039,725 Saskatchewan Grant-in-Aid ,000 Personnel Awards: Master's Studentship Award 1 0 Undergraduate Studentship Award 4 18, ,000 Manitoba Grant-in-Aid ,500 Personnel Awards: Sanofi Aventis/HSFM Award in Cardiology 1 10,000 Master's Student Award 1 1,000 B.Sc. in Medicine Studentship 3 15,000 Red River College (RRC) Summer Studentship Award 4 16, ,500 Ontario Grant-in-Aid ,906,230 Research Chairs*: Chair in Population Health Research 1 0** Chair in Cardiac Nursing 1 35,890 Chair in Cardiovascular Research 5 169,782 Personnel Awards: Distinguished Scientist 3 30,000 Career Investigator 31 2,574,725 Clinician Scientist ,250 Health Services/Population Health Research Post-Doctoral Research Fellowship 3 178,500 Health Services/Population Health Research Doctoral Research Award 1 31,000 Health Services/Population Health Research Master s Studentship Awards 2 37,000 Master's Studentship ,500 Summer Student Scholarship 17 76,000 Other Provincial Initiatives: Program Grant 3 749,989 Social Determinants of Hypertension 1 100,010 Pilot Project Grant 3 149,887 Congenital Heart Disease in Adults in the Province of Ontario's Operating Grant 1 99,668 Canadian Partnership Against Cancer CLASP Operating Grant 1 100,000 HSF Centre for Stroke Recovery 1 4,132,000 HSF/Richard Lewar Centre of Excellence ,373,431 Quebec Grant-in-Aid 76 1,696,000 Other Provincial Initiatives: Awards for Excellence in Research 9 90,000 Training Bursaries 2 13,333 Research Programs in Partnership 1 15,000 1,814,333 5

12 Heart and Stroke Foundation Research Report Foundation Program Awards (#) Awards ($) Total ($) New Brunswick Grant-in-Aid 5 276, ,505 Nova Scotia Grant-in-Aid ,715 Research Chairs*: Chair in Cardiovascular Outcomes Research 1 60,035 Other Provincial Initiatives: Dr. Gregory Ferrier Award 1 5,000 BrightRed Graduate Research Award 6 30, ,750 Prince Edward Island Grant-in-Aid Newfoundland and Grant-in-Aid 1 40,000 Labrador Personnel Awards: The Heart and Stroke Foundation Graduate Scholarship 1 1,000 The Keith Griffiths Memorial Heart and Stroke Foundation Graduate Scholarship 1 1,000 The Heart and Stroke Foundation of Newfoundland and Labrador Nursing Award 1 1,000 in Stroke The Heart and Stroke Foundation of Newfoundland and Labrador Nursing Award 1 1,000 in Cardiovascular Health 44,000 SUBTOTAL ,387,273 43,387,273 Federation Research Fund 84 3,629,994 3,629,994 National Personnel Awards 122 4,429,856 4,429,856 Canadian Stroke Network - 428, ,571 TOTAL 799 $51,875,694 51,875,694 * For the most part, Research Chair awards are funded by endowments and are partnered with academic / health research institutions. ** Reduced funding for Chairs for this year is linked to the institutions long-term strategy to maintain endowed fund market values above the original donated value. *** HSF contributions to the chairs and professorships had already been met, so no funds were awarded for the 2010/ year. Includes award stipends, obligatory benefits, and applicable travel and/or research allowances. Combined HSF provincial and national contributions - $3 million (2007-). 6

13 Heart and Stroke Foundation Research Report 3. RESEARCH FUNDING OVERVIEW 3.1 Research Roles Heart and Stroke Foundation of Canada Manages the peer review for all Grants-in-Aid (GIA). Manages peer review and award administration for all National Personnel Awards. Manages peer review and award administration for all aspects of the Federation Research Fund (FRF) strategic initiatives. Provincial Heart and Stroke Foundations Administer Grants-in-Aid, including funding decisions, award administration, monitoring and evaluation. Manage all aspects, including peer review, of provincespecific research initiatives. An exception is the Heart and Stroke Foundation of Ontario (HSFO) Career Investigator program, reviewed by a standing Heart and Stroke Foundation of Canada (HSFC) subcommittee. 3.2 Scientific Review Process Scientific peer review is the cornerstone of the Foundation s research enterprise. All research funded by HSF, at a national or provincial level, undergoes peer review and must meet criteria for scientific rigor. 3.3 Research Enterprise Components The HSF research enterprise contains four significant parts presented in Figure 1. The ten provincial Foundations invest over $50 million annually in the Grant-in-Aid program (research project operating grants); the National Personnel Awards program (salary awards at doctoral, post doctoral, and new investigator levels); the Federation Research Fund initiatives (strategic research initiatives primarily in partnership with other funding agencies); and provincial research initiatives (personnel awards, program grants, research chairs and other programs). While the overall amount invested in these grant and award funding expenditures have fluctuated over the last five years, but they have now nearly aligned with the $51 million investment made five years ago (Figure 2). Figure 1. HSF Research Funding by Program () Grant-in-Aid $33,172,979 64% Provincial Research Initiatives $10,642,865 20% Federation Research Fund $3,629,994 7% National Personnel Awards $4,429,856 9% The Scientific Review Committee (SRC) is responsible for maintaining a high standard peer review process for all applications reviewed through HSFC. In, over 150 of Canada s top cardio- and cerebrovascular scientists participated on the SRC, which is organized around subcommittees, each having specific expertise. Collectively the SRC has the ability to expertly review applications focusing on any health research theme, from basic biomedical to population health. HSFC assigns a lay reviewer to each subcommittee reviewing GIA and Senior Personnel Awards applications. The objectives of the lay reviewer role are to enhance the accountability and integrity of the HSF peer review process, provide an additional mechanism for evaluating relevance of projects to the HSF mission, and increase awareness of the importance of knowledge transfer and exchange. At the provincial level, committee structure varies by province. Research, budgetary allocation, and peer review committees all have roles in funding and review of provincial initiatives. 7

14 Heart and Stroke Foundation Research Report Figure 2. HSF Research Funding Trends by Program (2006-) Numbers represent $ Millions Federation Research Fund National Personnel Awards Figures 3 and 4 show the relative HSF investments across health research themes. Further in the report, funding by health research theme in each of the federation-wide programs is presented. Currently, we do not have data on provincial initiatives by theme. Figure 3. HSF Research Funding by Health Research Theme () Basic Biomedical 72% Clinical 19% Basic Health Services/ Biomedical Systems 4% 72% Population Health 5% Clinical 19% He Sy P H Grant-in-Aid Includes Federation Research Fund, National Personnel Awards (stipends only), and Grant-in-Aid funding. Figure 4. HSF Research Funding Trends by Health Research Theme (2006-) Numbers represent $ Millions Basic Biomedical 72% Clinical 19% Health Services/ Systems 4% Population 51.0 Health 5% Investments across Health Research Themes fig 2 eng Provincial Research Initiatives Total Includes Research Chair values. Research supported by HSF spans the four health research themes: basic biomedical, clinical, health services/systems, and population health (defined in Appendix H) Basic Biomedical Clinical Health Services/Systems Population Health fig 3 eng Includes Federation Research Fund, National Personnel Awards (stipends only), and Grant-in-Aid funding. 8

15 Heart and Stroke Foundation Research Report 4. RESEARCH FUNDING BY PROGRAM This section provides summary information for each of the four main components of the HSF research enterprise: Federation-wide research programs: 1. Federation Research Fund 2. National Personnel Awards 3. Grant-in-Aid 4. Province-specific research initiatives: i. Provincial Research Chairs ii. Provincial Personnel Awards iii. Other Provincial Research Initiatives 4.1 Federation Research Fund The Federation Research Fund (FRF) supports research in areas of strategic priority to the Foundation, typically through a Request for Applications process, and in partnership with other agencies and organizations. New initiatives appearing in this year s report include: 1) Monitoring and Optimizing CPR This strategic initiative aims to support research in monitoring and optimizing the technical aspects of CPR, which will ultimately result in enhanced quality CPR and improved outcomes in both adult and pediatric populations. This is the Foundation s second round of funding in this important area (the first round was launched in 2007). 2 Resuscitation and Knowledge Transfer First launched in 2007, this strategic initiative was re-launched in 2010 to further support research that explores how present and proposed policies, strategies, tools, training approaches, legislation or guidelines related to knowledge transfer and exchange of resuscitation science, influence the uptake of knowledge by health care providers, lay rescuers, and/ or first responders. Findings are expected to contribute to the development of new or improved knowledge transfer policies, mechanisms and/or tools that will help improve survival outcomes from sudden cardiac arrest and ultimately, reduce disability and death among Canadians. 3) Built Environment: Population Health Intervention Research. This initiative supports multidisciplinary/multisectoral projects that examine programs, events, and/or policy changes related to the built environment that have the potential to impact health, specifically obesity, at the population level. The first iteration of this Request for Applications was launched in 2007, with the aim to advance knowledge on how the built environment influenced obesity and health. In this second iteration, HSF and partners further focused the aim of the initiative to specifically support built environment research that impacts health at the population level. 4) Operating Grant: Population Health Intervention Research. This initiative aims to support the prompt initiation of intervention research on rapidly unfolding programs, policies and resource distribution approaches that have the potential to impact health and health equity at the population level. 5) Novel and Exploratory Research Fund This special competition provides one-year funding for paradigm-shifting research that has the potential for momentous impacts on heart disease and stroke. 6) HSFC / PFC Scholarships in Physiotherapy Research This initiative aims to encourage and recognize highly qualified academic physiotherapy researchers at the early stages of their career, in an area relevant to heart disease and stroke. 7) CIHR/HSFC Training Awards in Population Intervention for Chronic Disease Prevention: A Pan-Canadian Program. This strategic training initiative aims to increase the capacity for population intervention research in Canada by training students as impact-oriented scientists who work collaboratively across disciplines and sectors to address the most relevant questions using the most appropriate and rigorous methods, to improve population interventions for chronic disease prevention. 8) Jump Start Resuscitation. In 2010, the Foundation launched the inaugural round of Jump Start Resuscitation, a strategic initiative that aims to build greater capacity for resuscitation research in Canada and to support the next generation of researchers who will contribute to advancing knowledge and improving the quality of patient care and outcomes in this important area. Available through the program is a wide range of Personnel Awards - from Master s Studentships to Doctoral Research Awards, Research Fellowships, and Research Scholarships. 9) Focus on Stroke This long-standing initiative, led by HSF, offers Doctoral Research Awards, Research Fellowships, and Research Scholarships in the area of stroke. The goal is to build greater capacity for later pillar stroke research and to support the next generation of stroke researchers. 9

16 Heart and Stroke Foundation Research Report The majority of the 3.7 projects listed in Appendix A represent the continuation of previously 11.9 reported research investments. A total of 26 initiatives, representing 84 individual grants and awards, are detailed 3.6 in Appendix A. 9.2 The total value of the Foundation s investment in these strategic 3.5 projects for is over $3.6 million. In addition to the 6.9 Foundation s investment, partner funds have further extended the FRF research portfolio, leveraging donors dollars. As outlined in Figure 5, 5.2 Foundation funding is leveraged by a ratio of over one to one. Of note, the trend depicted in Figure 5 shows 1 a declining 3.6 rate of leveraging over the years due to a more focused 4.8 alignment of the FRF s investments with the strategic mission priorities of the Foundation (as per the Intellectual Framework). In addition, the Managed Research Cycle, an approach to funding that links research outcomes to the end users and through which the FRF investments are guided, is reaching maturity with several HSF-led researcher interaction workshops and other investments to facilitate knowledge transfer and exchange already taking place and the on-set of synthesis activities of completed initiatives. Figure 5. Federation Research Clinical 37% Fund Leveraged Funding ical 17% (2006-) Population Health 28% ng Numbers represent $ Millions Health 11.9 Services/ Systems 18% HSFC Partner(s) One of the objectives of the FRF is to support interdisciplinary research in the areas of health services/systems and population health. Figures 6 and 7 illustrate significant progress in achieving this objective while remaining responsive across health research themes. It is important to note, however, that the FRF represents less than 10% of the Foundation s overall research investment. Figure 6. Federation Research Fund Funding by Health Research Theme () Basic Biomedical 17% Population Health 28% Clinical 37% Health Services/ Systems 18% Figure 7. Federation Research Fund Funding Trends by Health Research Theme (2006-) fig 7 eng Numbers represent $ Millions Basic Biomedical Clinical Health Services/Systems Population Health National Personnel Awards National Personnel Awards build Canada s cardio- and cerebrovascular research capacity by providing salary support to investigators at early scientific career stages. The programs included Distinguished Clinician Scientist, New Investigator, Research Scholarship, Research Fellowship and Doctoral Research Award. 10

17 Heart and Stroke Foundation Research Report National Personnel Awards Programs in Distinguished Clinician Scientist A salary award to support clinical new investigators who wish to establish their own independent research laboratory. This award is given to the highest ranked eligible clinician in the New Investigator competition ($75,000 stipend + $25,000 research allowance per year for five years, including fringe benefits). This award is partnered with other agencies. New Investigator A salary award to support new investigators who wish to establish their own independent research laboratory ($60,000 per year for five years, including fringe benefits). Research Scholarship A salary award intended for individuals with a Masters and/or PhD and with credential(s) in a regulated accredited health discipline. The applicant must hold a faculty appointment and have (less than 5 years) research experience. ($45,000 + $5,000 research allowance, per year for two years). Research Fellowship A training award for applicants who have completed a professional degree, MD or PhD (up to $50,000 per year for up to three years). In, 122 new and continuing awards were funded. This included 4 awards supported in part by industry. The total HSF investment in National Personnel Awards in was over $4.4 million (Table 3). A list of award recipients can be found in Appendix B. Table 3. Number of National Personnel Awards and Investment of Funds () Program Recipients (#) Funds Invested ($) Distinguished Clinician 2 115,000 Scientist New Investigator 34 1,740,833 Research Scholarship 2 90,000 Research Fellowship 54 1,830,137 Doctoral Research Awards ,041 Obligatory Benefits - - Travel Allowance - 60,134 Research Allowance - 31,710 TOTAL 122 $4,429,856 Table 4 highlights the distribution of National Personnel Awards by health research theme. In, the majority of awards were in the basic biomedical area (83%). This is consistent with previous years (Figures 8 and 9). Doctoral Research Award A training award for graduate students, enrolled in a PhD program, who are undertaking full-time research training ($21,000 per year for up to three years). Table 4. HSF National Personnel Awards by Health Research Theme () Type of Award Basic Biomedical Clinical Health Services/Systems Population Health Total (#) ($) (#) ($) (#) ($) (#) ($) (#) ($) Distinguished Clinician , , ,000 Scientist New Investigator ,455, , , ,740,833 Research Scholarship , , , ,000 Research Fellowship ,608, , , ,830,137 Doctoral Research Awards , , , ,041 TOTAL $3,606, $627, $23, $81, $4,338,011 Includes award stipends only. 11

18 Heart and Stroke Foundation Research Report Numbers represent $ Millions Figure 8. National Personnel Awards Funding by Health Research Theme () Basic Biomedical Clinical % Health 4.5 Services/ 3.6 Systems 1% Population Health 2% Basic Biomedical 83% Figure 9. National Personnel Awards Funding Trends by fig 9 eng Clinical fig 9 eng Health Services/Systems Population Health Includes award stipends only. Clinical Health Services/Systems Includes award stipends only Health Research 2010 Theme 0.0 (2006-) 0.0 Numbers represent $ Millions Population Health Basic Biomedical B.C./Yukon Alta./N.W.T./Nunavut Sask. Que. 46 Numbers represent 6 $ Millions Canadians studying abroad Man. 9 0 Ont. Que. There is a wide variation by province in applications submitted and funded. For example, very few National Personnel Awards P.E.I. applications are funded in the Atlantic provinces, Manitoba, and Saskatchewan (Figure 10). The overall success rate for the N.L. National Personnel Awards competitions in was approximately 13%. Canadians studying abroad 12 Figure 10. Number of National Personnel Award Applications Submitted and Funded by Province/ Territory () Numbers represent $ Millions N.B. N.S. Applications N.B. 0 Submitted 0 Applications Funded B.C./Yukon Alta./N.W.T./Nunavut Sask. Man. Ont. N.S. P.E.I. N.L. 102 Applications Submitted Applications Funded fig 10 eng 102

19 Heart and Stroke Foundation Research Report Heart and Stroke Foundation Prestigious Awards Each year, the Heart and Stroke Foundation recognizes leadership and scientific excellence through the following prestigious awards. McDonald Scholarship The McDonald Scholarship is named in honour of Ewing McDonald, the Heart and Stroke Foundation of Canada s Executive Director from 1968 to This award is given annually to the highest-rated applicant in the New Investigator program. The recipient is awarded a $15,000 research grant (in addition to the $60,000 New Investigator award stipend). Dr. Gavin Y. Oudit from the Alberta was the Heart and Stroke Foundation s McDonald Scholar. Dr. Oudit is working on clinical development of human combination ACE2, a human synthetic form of enzyme, as a potential therapy. Henry J.M. Barnett Scholarship The Henry J.M. Barnett Scholarship was established to honour Dr. Henry J.M. Barnett s exceptional contributions to stroke research, education, and patient care in Canada. This award is presented annually to a highly rated investigator applicant working in stroke research. The recipient is awarded a $15,000 research grant (in addition to the $60,000 investigator award stipend). Dr. Majid Heidari-Mohajerani, a Research Fellow from the British Columbia was the Heart and Stroke Foundation s Barnett Scholar. Dr. Mohajerani is exploring how molecular, cellular, and synaptic mechanisms lead to the recovery of affected regions of the brain for stroke survivors. Distinguished Clinician Scientist Award The Distinguished Clinician Scientist award was established in 2009 as part of the New Investigator competition. This award is offered to the highest ranked eligible clinician (i.e. licensed to practice in a regulated health discipline) in the New Investigator competition. In 2010, this award was partnered with the Canadian Institutes of Health Research - Institute of Circulatory and Respiratory. The Distinguished Clinician Scientist award carries a higher stipend ($75,000) than the New Investigator award, plus an additional annual research allowance ($25,000). In, Dr. Gavin Y. Oudit from the Alberta was the recipient of the Distinguished Clinician Scientist award. 4.3 Grant-in-Aid Grants-in-Aid (peer-reviewed nationally, and funded and administered provincially) are the largest category of research expenditure for the Heart and Stroke Foundation. The Grant-in- Aid program supports the direct operating costs of conducting research, including laboratory supplies, technicians, and some equipment. Grant amounts vary, but typically range from $10,000 to a maximum of $300,000 per year. In, 450 Grants-in-Aid (new and continuing) were funded, representing an investment of over $33.1 million (Table 5). A list of grant recipients can be found in Appendix C. Table 5. Number of Grants-in-Aid and Investment of Funds () Foundation Recipients (#) Funds Invested ($) British Columbia/Yukon 33 2,883,029 Alberta/Northwest Territories/Nunavut 47 2,720,000 Saskatchewan ,000 Manitoba ,500 Ontario ,906,230 Quebec 76 1,696,000 New Brunswick 5 276,505 Nova Scotia ,715 Prince-Edward-Island - - Newfoundland and Labrador 1 40,000 TOTAL 450 $33,172,979 Grants-in-Aid are heavily concentrated ($25.3 million or 76% of overall expenditure) in the basic biomedical sciences (Figures 11 and 12). Figure 11. Grant-in-Aid Funding by Health Research Theme () Clinical 18% Health Services/ Systems 3% Population Health 3% Basic Biomedical 76% 13

20 Heart and Stroke Foundation Research Report lions Figure 12. Grant-in-Aid Funding Trends by Health 25.3 Research Theme (2006-) 26.1 Numbers represent $ Millions Basic Biomedical ms Clinical Health Services/Systems Population Health The number of applications submitted and funded in the Grant-in-Aid program varies widely across provinces (Figures 13 and 14). The average Grant-in-Aid amount invested in was approximately $73,718 with Ontario supporting the largest grant amount ($223,389). The overall success rate for the Grant-in-Aid competition in was 28%. Figure 13. Number of Grant-in-Aid Applications Submitted by Province/Territory (2006-) Numbers represent $ Millions B.C./Yukon N.B Alta./N.W.T./Nunavut Sask Man. Ont. Que N.S P.E.I N.L

21 Heart and Stroke Foundation Research Report Figure 14. Number of Grant-in-Aid Applications Funded by Province/Territory (2006-) B.C./Yukon Alta./N.W.T./Nunavut Sask Man Province-specific Research Initiatives In addition to the Grant-in-Aid program, many of the provincial Foundations administer Research Chairs and Professorships; provincial Personnel Awards; and other research initiatives Research Chairs and Professorships Research Chair funding provides salary and infrastructure support to enable a leading researcher to develop a particular research focus at a Canadian university. In a total of 15 Chairs and Professorships were supported by HSF in the areas of cardiology, stroke, cardiac nursing, obesity, and population health. This represents an investment of over $700 thousand (see Table 6). The recipients of these Chairs and Professorships can be found in Appendix D. In, Dr. Andrew Demchuk was appointed as the inaugural Chair holder of the Heart and Stroke Foundation of Alberta, NWT & Nunavut Chair in Stroke Research at the Calgary. This Chairship is supported by an endowment of $3 million. Dr. Demchuk will provide leadership in the development of translational stroke research in Southern Alberta and promote collaborative research across disciplines Ont. Que. N.B N.S P.E.I N.L

22 Heart and Stroke Foundation Research Report Table 6. Research Chairs and Professorships () Foundation Program Awards (#) Awards ($) Total ($) British Columbia/Yukon Chair in Cardiovascular Prevention Research 1 150,000 Chair in Stroke Research 1 0** Professorship in Clinical Stroke Research 1 0** 150,000 Alberta/Northwest Territories/Nunavut Chair in Cardiovascular Research 2 222,137 Chair in Stroke Research 1 37,588 Professorship in Stroke Research 1 60, ,725 Saskatchewan Manitoba Ontario Chair in Population Health Research 1 0* Chair in Cardiac Nursing 1 35,890 Chair in Cardiovascular Research 5 169, ,672 Quebec New Brunswick Nova Scotia Chair in Cardiovascular Outcomes Research 1 60,035 60,035 Prince Edward Island Newfoundland and Labrador TOTAL 15 $735,432 $735,432 For the most part, Research Chair awards are funded by endowments and are partnered with academic/health research institutions. * Reduced funding for Chairs for this year is linked to the institutions long-term strategy to maintain endowed fund market values above the original donated value. **HSF contributions to the chairs and professorships had already been met, so no funds were awarded for the 2010/ year. 16

23 Heart and Stroke Foundation Research Report Provincial Personnel Awards In, the provincial Foundations funded a total of 98 Personnel Awards, building capacity by supporting cardio- and cerebrovascular researchers throughout their careers, from high school students working in research settings to established senior scientists (Table 7). The recipients of these awards can be found in Appendix E. Table 7. HSF Provincial Personnel Awards Funded () Foundation Program Awards (#) Awards ($) Total ($) British Columbia/Yukon Alberta/Northwest Territories/Nunavut Saskatchewan Master's Studentship Award 1 0 Undergraduate Studentship Award 4 18,000 18,000 Manitoba Sanofi Aventis/HSFM Award in Cardiology 1 10,000 Master's Student Award 1 1,000 B.Sc. in Medicine Studentship 3 15,000 Red River College (RRC) Summer Studentship Award 4 16,000 42,000 Ontario Distinguished Scientist 3 30,000 Career Investigator 31 2,574,725 Clinician Scientist ,250 Health Services/Population Health Research Post- Doctoral Research Fellowship Awards 3 178,500 Health Services/Population Health Research Doctoral Research Award 1 31,000 Health Services/Population Health Research Master s Studentship Awards 2 37,000 Master's Studentship ,500 Summer Student Scholarship 17 76,000 3,929,975 Quebec New Brunswick Nova Scotia Prince Edward Island Newfoundland and Labrador The Heart and Stroke Foundation Graduate Scholarship 1 1,000 The Keith Griffiths Memorial Heart and Stroke Foundation Graduate Scholarship 1 1,000 The Heart and Stroke Foundation of Newfoundland and Labrador Nursing Award in Stroke 1 1,000 The Heart and Stroke Foundation of Newfoundland and Labrador Nursing Award in Cardiovascular Health 1 1,000 4,000 TOTAL 98 $3,993,975 $3,993,975 17

24 Heart and Stroke Foundation Research Report Description of Provincial Personnel Awards Heart and Stroke Foundation of Saskatchewan (HSFS) Master s Studentship Award A training award to highly qualified candidates who are interested in research. Candidates will undertake full-time training in heart and stroke research in any of the pillars of health research. The award will normally commence on September 1 st (but no later than January 1 st of the following year) and run for 12 consecutive months. The annual award is $17,500 and may be granted for a maximum of two years. Undergraduate Studentship Award A training award for students enrolled in a full-time undergraduate program who are interested in pursuing research. The award is for $4,500 for a maximum of 16 consecutive weeks on a full-time basis beginning May 1 st and ending August 31 st. Heart and Stroke Foundation of Manitoba (HSFM) Sanofi Aventis / Heart and Stroke Foundation of Manitoba Award in Cardiology This $10,000 award is given to stimulate and support excellence in research and scholarly activity in the discipline of Cardiology at the Manitoba. The award funds a clinical cardiology resident, preferably in their third year, who demonstrates academic excellence within the clinical residency program, possesses humanistic qualities with respect to patient care, collegiality and interpersonal dealings with medical and paramedical staff, has clinical competence in the field, and is expected to pursue further academic training beyond core cardiology. Master s Student Award This award was established by HSFM to encourage the training of young investigators in cardiovascular sciences in Manitoba and to recognize the achievements of a student at the Master s level. The award total is $1,000. B.Sc. in Medicine Studentship The Summer Research Studentships in Medicine support individuals in the Bachelor of Science in Medicine Program while working with senior researchers during the summer months. Three summer studentships totaling $15,000 ($5,000 each) were awarded. Red River College (RRC) Summer Studentship Award The Red River College Summer Studentship awards support top tier students in the Chemical and Biosciences Technology program to assist them in securing cooperative work terms with medical researchers during the summer months. Four studentships totaling $16,000 ($4,000 each) were awarded. Heart and Stroke Foundation of Ontario (HSFO) Distinguished Scientist: Fortino s Distinguished Scientist Award Supplementary funding for five years for the highest rated Career Investigator at McMaster. Sifton Distinguished Scientist Award Supplementary funding for five years for the highest rated Career Investigator at the Toronto. Dr. Lowell Langille Tribute Award Supplementary funding for highest rated Career Investigator Award recipient to use to support trainee mentoring activities. Career Investigator Stipend support for up to five years for investigators of national/international stature. Clinician Scientist Phase 1 Stipend support for up to three years for junior healthcare clinicians where no more than three years have elapsed since their first academic appointment. Clinician Scientist Phase 2 Stipend support for up to three years for healthcare clinicians where no more than seven years have elapsed since their first academic appointment. Health Services/Population Health Research Post-Doctoral Research Fellowship Stipend support for up to three years for individuals undertaking health services and/or population health research, where no more than three years has elapsed since receiving a PhD. Health Services/Population Health Research Doctoral Research Award Stipend support for up to three years for graduate students enrolled in a PhD or joint MD/PhD program who are undertaking training in health services and/or population health research. Health Services/Population Health Research Master s Studentship Stipend support for up to two years for highly qualified individuals to undertake full-time training under an academic supervisor in fields of health services and/or population health research. Master s Studentship Stipend support for up to two years for highly qualified individuals to undertake full-time research training under an academic supervisor. Summer Student Scholarship: Medical Student Award Stipend support for up to four months for medical students to work with established investigators conducting research. 18

25 Heart and Stroke Foundation Research Report Heart and Stroke Foundation of Newfoundland and Labrador (HSFNL) The Heart and Stroke Foundation Graduate Scholarship This scholarship, valued at $1,000 per annum, is awarded to a fulltime graduate level student in the Faculty of Medicine, who is pursuing a research program related to cardiovascular disease. The Keith Griffiths Memorial Heart and Stroke Foundation Graduate Scholarship This scholarship, valued at $1,000 per annum, was established through a generous contribution by the Griffiths family, in memory of their father, Keith Griffiths, a stroke survivor and dedicated volunteer, and in partnership with the Heart and Stroke Foundation. The scholarship is awarded to a full-time graduate level student in the Faculty of Medicine, who is pursuing a research program in stroke or neurological issues related to stroke. The Heart and Stroke Foundation of Newfoundland and Labrador Nursing Award in Stroke This scholarship, valued at $1,000 annually, is awarded to an undergraduate student in any year of the Bachelor of Nursing program at the School of Nursing who demonstrates an interest in patient health related to stroke care, have actively volunteered with the Heart and Stroke Foundation and also have met the minimum academic requirements for an award. The Heart and Stroke Foundation of Newfoundland and Labrador Nursing Award in Cardiovascular Health This scholarship, valued at $1,000 annually, is awarded to an undergraduate student in any year of the Bachelor of Nursing program at the School of Nursing who demonstrates an interest in cardiovascular health, have actively volunteered with the Heart and Stroke Foundation and also have met the minimum academic requirements for an award Other Provincial Initiatives In, the provincial Foundations funded a wide variety of other research initiatives. Table 8 provides details of these initiatives and a list of recipients can be found in Appendix F. Table 8. Other Provincial Research Initiatives () Foundation Program Awards (#) Awards ($) Total ($) British Columbia/Yukon Alberta/Northwest Territories/Nunavut Saskatchewan Manitoba Ontario Program Grant 3 749,989 Social Determinants of Hypertension 1 100,010 Pilot Project Grant 3 149,887 Congenital Heart Disease in Adults in the Province of Ontario's Operating Grant 1 99,668 Canadian Partnership Against Cancer CLASP Operating Grant 1 100,000 HSF Centre for Stroke Recovery 1 4,132,000 HSF/Richard Lewar Centre of Excellence 1 0 5,331,554 Quebec Awards for Excellence in Research 9 90,000 Training Bursaries 2 13,333 Research Programs in Partnership 1 15, ,333 New Brunswick Nova Scotia Dr. Gregory Ferrier Award 1 5,000 BrightRed Graduate Research Award 6 30,000 35,000 Prince Edward Island Newfoundland and Labrador Canadian Stroke Network - 428, ,571 TOTAL 30 $5,913,458 $5,913,458 Combined HSF provincial and national contributions - $3 million (2007-) 19

26 Heart and Stroke Foundation Research Report Description of Other Provincial Research Initiatives Heart and Stroke Foundation of Ontario (HSFO) Program Grants These grants provide support for teams of three or more investigators engaging in collaborative, multidisciplinary research in the fields of cardio- and cerebrovascular disease in Ontario institutions. Social Determinants of Hypertension Through this competition, multi-disciplinary, collaborative applications were sought focusing on identifying the less well understood social determinants of hypertension. Pilot Project Grant Small operating grants intended to enable investigators to generate preliminary data, validate methodologies or test hypotheses that will lead to subsequent success of recipients in the Foundation s open competitions. Congenital Heart Disease in Adults in the Province of Ontario s Operating Grant The primary objective is to use the Institute for Clinical Evaluative Sciences database to correctly identify adults with congenital heart defects. Secondary objectives are to use coding mechanisms to a) calculate the total population of adults with congenital heart disease in Ontario, and b) determine their health care utilization. Canadian Partnership Against Cancer CLASP Operating Grant The project incorporates a close collaboration with Aboriginal communities to increase the adoption and implementation of community-based education and behaviour change strategies that address the consumption of unhealthy imported foods, while providing incentives for the production and local distribution of healthy and culturally relevant food. Heart and Stroke Foundation Centre for Stroke Recovery A virtual centre of excellence with scientists in Ottawa and Toronto working collaboratively across the entire spectrum of molecular studies, laboratory models, human clinical trials, cognitive evaluation, and imaging modalities. The Centre s mandate is to improve recovery from stroke through the discovery, mobilization and testing of brain repair. Heart and Stroke/Richard Lewar Centre of Excellence in Cardiovascular Research Focused on the prevention and cure of atherosclerosis, heart failure and congenital heart disease. From this research will evolve diagnostic, prognostic, and therapeutic innovations that can impact on the health of all Canadians. Heart and Stroke Foundation of Quebec (HSFQ) Awards for Excellence in Research A number of Awards for Excellence in Research are awarded each year by HSFQ in partnership with individual and corporate donors. These awards enhance the Grant-in-Aid program and provide additional financial support to Quebec researchers. The awards range from $5,000 to $20,000. Training Bursaries for PhD students in Cardiovascular and Stroke Research Partnership between the Fonds de la recherche en santé du Québec (FRSQ), the Réseau en santé cardiovasculaire (RSCV) and the Heart and Stroke Foundation of Québec (HSFQ). The partners offer training bursaries for PhD students working with researchers receiving a Grant-in-Aid from the Heart and Stroke Foundation of Québec (HSFQ). Research Programs in Parternship Partnership between the Sainte-Justine UHC Foundation and the Heart and Stroke Foundation of Québec for the CIRCUIT program. This program helps children and youth with cardiovascular disease to be physically more active. Heart and Stroke Foundation of Nova Scotia (HSFNS) Dr. Gregory Ferrier Award HSFNS offers an award for excellence in research. This award is given annually to the highest rated HSFNS Grant-in-Aid recipient in honour of Dr. Gregory Ferrier, an internationally respected, award-winning scientist known for his groundbreaking and innovative research program related to heart failure mechanisms. The award also honours the spirit of Dr. Ferrier s mentorship to a new generation of researchers; he went above and beyond to ensure they were able to conduct their research in Nova Scotia. A stipend of $5,000 is awarded to the grant budget in support of student funding in recognition of Dr. Ferrier s commitment to research training. BrightRed Graduate Research Award The BrightRed Graduate Research Awards Program recognizes excellent emerging cardiovascular and cerebrovascular researchers in Nova Scotia at differing stages of career development, by providing financial support to students and trainees enrolled in research-based Masters, Doctorate, or Postdoctorate programs at academic institutions in Nova Scotia. 20

27 APPENDIX A FEDERATION RESEARCH FUND Photo: Dr. Jason A. Gilliland ( Western Ontario) lead a team funded in through an award titled Identifying causal effects of the built environment on physical activity, diet, and obesity among children. The award is part of the Federation Research Fund s Built Environment: Population Health Intervention Research 2010 initiative.

28 Heart and Stroke Foundation Research Report NEW INITIATIVES Monitoring and Optimizing CPR 2010 Partners: HSF (lead); CIHR Institute of Circulatory and Respiratory Health. Total initiative funding: $1,020,470 Total HSF funding: $920,470 Description: The goal of this strategic initiative is to support research in monitoring and optimizing the technical aspects of CPR, which will ultimately result in enhanced quality CPR and improved outcomes in both adult and paediatric populations. Monitoring and Optimizing CPR 2010 Principal Investigator(s) Institute Project Co-Investigator(s) Term 10/11 $ HSF Total 10/11 $ (All Partners) Total $ HSF Total $ (All Partners) Theme Cheng, Adam M. Alberta Children's Hospital Assessing and improving the quality of cardiopulmonary resuscitation (CPR) delivered during simulated pediatric cardiac arrest using a novel pediatric CPR feedback device. Alberta: de Caen, Allan; Duff, Jonathan; Grant, Vincent J. Québec : Bhanji, Farhan; Gottesman, Ronald D. USA: Cason, Carolyn L; Hunt, Elizabeth; Nadkarni, Vinay M.; Sutton, Robert ,441 49, , ,067 II Gilfoyle, Elaine Calgary Can adherance to PALS guidelines be improved by team training of pediatric resuscitation team members? Alberta: Cheng, Adam; Duff, Jonathan; Grant, Estée Christa; Grant, Vincent J. New Brunswick: Annear, John C. Ontario: Lobos, Anna-Theresa; St. George-Hyslop, Cecilia; Writer, Hilary K. Québec: Bhanji, Farhan; Gottesman, Ronald D ,109 55, , ,038 III Nanthakumar, Kumaraswamy Toronto General Hospital Extending real time monitoring of ventricular fibrillation dynamics from the human Langendorff model to cardiac arrest in the community for optimizing resuscitation outcomes. Ontario: Dorian, Paul; Umapathy, Karthikeyan. 27,566 33,122 93,809 99,365 I, II, III 22

29 Heart and Stroke Foundation Research Report Resuscitation and Knowledge Transfer 2010 Partners: HSF (lead); CIHR Institute of Circulatory and Respiratory Health. Total initiative funding: $591,092 Total HSF funding: $492,647 Description: The goal of this initiative is to fund research that explores how present and proposed policies, strategies, tools, training approaches, legislation or guidelines relating to knowledge transfer of resuscitation science influence the uptake of knowledge by layrescuers and/or first responders. The results of the research should lead to the development of new or improved knowledge transfer policies, mechanisms, and/or tools that will help improve survival outcomes from sudden cardiac arrest and ultimately, reduce disability and death among Canadians. Resuscitation and Knowledge Transfer 2010 Principal Investigator(s) Institute Project Co-Investigator(s) Term 10/11 $ HSF Total 10/11 $ (All Partners) Total $ HSF Total $ (All Partners) Theme Brooks, Steven C St. Michael's Hospital The PACT study: the impact of a post arrest consult team on process and clinical outcomes in patients resuscitated from out-of-hospital cardiac arrest. Ontario: Chapman, Martin; Crystal, Eugene; Dainty, Katie N.; Dorian, Paul; Fam, Neil; Friedrich, Jan; Gray, Sarah; Jeffs, Lianne P.; Madan, Minakshi; Morrison, Laurie J.; Rubenfeld, Gordon D.; Scales, Damon C.; Szadkowski, Leah M. 0 33, , ,726 II, III Morrison, Laurie J. St. Michael's Hospital Gender differences in access to post arrest care. Ontario: Abramson, Beth L.; Dainty, Katie N.; Dorian, Paul; Kiss, Alexander J.; Parsons, Janet A.; Rac, Valeria E.; Slutsky, Arthur S.; Zwarenstein, Merrick F. 0 33, , ,246 II, III Scales, Damon C. Sunnybrook Health Sciences Centre Premature termination of resuscitation in survivors of cardiac arrest (Prema TOR). Ontario: Brooks, Steven C.; Chapman, Martin G.; Dale, Craig; Golan, Eyal; Morrison, Laurie J.; Young, Bryan; Zwarenstein, Merrick F. 0 32, , ,120 II, III, IV Themes I: Basic Biomedical II: Clinical III: Health Services/Systems IV: Population Health 23

30 Heart and Stroke Foundation Research Report Built Environment: Population Health Intervention Research 2010 Partners: HSF (lead); CIHR Institute of Human Development, Child and Youth Health; Institute of Nutrition, Metabolism and Diabetes; and Institute of Population and Public Health. Total initiative funding: $1,744,771 Total HSF funding: $521,320 Description: Increased obesity rates in Canada are believed to contribute to the prevalence of cardio- and cerebro-vascular disease and are threatening population health. In a continued effort to find solutions to this growing epidemic, the funding partners wish to support rigorous scientific studies on interventions - programs, events, and/or policy changes - related to the built environment (outcome of community planning, design and implementation) that have the potential to address health issues, e.g., obesity, at the population level. Built Environment: Population Health Intervention Research 2010 Principal Investigator(s) Institute Project Co-Investigator(s) Term 10/11 $ HSF Total 10/11 $ (All Partners) Total $ HSF Total $ (All Partners) Theme Frank, Lawrence D.; Brauer, Michael of British Columbia A moving study: physical activity and diet before and after residential relocation. British Columbia: Black, Jennifer L.; Davies, Hugh W.; Millar, John S.; Ontario: Craig, Cora Lynn. 22,223 66, , ,000 IV Gilliland, Jason A. of Western Ontario Identifying causal effects of the built environment on physical activity, diet, and obesity among children. Ontario: Avison, William R.; Fleming, John; Gobert, Colleen; Hess, Paul M.; Prapavessis, Harry; Speechly, Kathy; Wilk, Piotr , , ,168 IV Kirk, Sara F.L.; Rainham, Daniel G. Dalhousie TIME (Tools, Information, Motivation, Environment) for health: a multi-level intervention to promote healthy eating in children and their families. Nova Scotia: Abidi, Syed Sibte Raza; Alvaro, Celeste; Blanchard, Chris M.; Chircop, Andrea M.; Molloy, David J.; Rehman, Laurene A.; Shearer, Cindy L ,664 66, , ,603 III, IV 24

31 Heart and Stroke Foundation Research Report Novel and Exploratory Research Fund 2010 Partner(s): HSF (lead). Total initiative funding: $50,000 Total HSF funding: $50,000 Description: These one-year grants aim to support paradigm-shifting research that has the potential for momentous impacts on heart disease and stroke. Each year, only the top two rated applicants from each of the Scientific Review Sub-committees are invited to apply. Novel and Exploratory Research Fund 2010 Principal Investigator(s) Institute Project Co-Investigator(s) Term 10/11 $ HSF Total 10/11 $ (All Partners) Total $ HSF Total $ (All Partners) Theme Zhang, Shetuan Queen's Exploring a novel way to treat lifethreatening cardiac disorder long QT syndrome using functional foods (lipids). Ontario: Funk, Colin D. 50,000 50,000 50,000 50,000 I, II Themes I: Basic Biomedical II: Clinical III: Health Services/Systems IV: Population Health 25

32 Heart and Stroke Foundation Research Report Operating Grant: Population Health Intervention Research Partners: CIHR Institute of Population and Public Health and Institute of Nutrition, Metabolism and Diabetes; Canadian Institute for Health Information; Public Health Agency of Canada; HSF. Total initiative funding: $385,329 Total HSF funding: $74,000 Description: The purpose of this funding opportunity is to support the prompt initiation of population health intervention research on rapidly unfolding programs, policies and resource distribution approaches that have the potential to impact health and health equity at the population level. The initiative strongly encourages close collaboration between program implementers (e.g., decision-makers) and researchers. This program is a continuation of the Intervention Research (Healthy Living and Chronic Disease Prevention) competition on which HSF has been involved as funding partner. HSF continues to support projects in this important area and in this round, co-funds two projects (out of a total of ten). Operating Grant: Population Health Intervention Research Principal Investigator(s) Finegood, Diane Tucker, Patricia Institute Project Co-Investigator(s) Term 10/11 $ Total 10/11 $ HSF (All Partners) Simon Fraser Scale-up and spread MEND programs in Canada. Are Canadian of Western preschoolers sufficiently Ontario active? An objective assessment of physical activity levels in childcare and full day early learning centres. Total $ Total $ Theme HSF (All Partners) Alberta: Ball, Geoff D.C.; MacDonald, Neil; Maloff, Bretta; McNeil, Deborah; Raine, Kim D.; Spence, John C.; United Kingdom: Calitz, Chris; Sacher, Paul ,000 37, ,000 III, IV Ontario: Burke, ,329 37, ,329 IV Shauna M.; Irwin, Jennifer D.; Johnson, Andrew M.; Killip, Steve; Rae, Anne. 26

33 Heart and Stroke Foundation Research Report HSFC/PFC Scholarships in Physiotherapy Research 2010 Partners: Physiotherapy Foundation of Canada; HSF. Total initiative funding: $9,000 Total HSF funding: $9,000 Description: This program recognizes highly qualified academic researchers who are pursuing, at the early stages of their career, physiotherapy research in an area relevant to heart disease or stroke care and rehabilitation. Only two Scholarships are offered per year: one at the master s level and one at the doctoral level. Doctoral-level Scholarship Awardee Institute Project Supervisor(s) Term 10/11 $ Total 10/11 $ Total $ Total $ Theme HSF (All Partners) HSF (All Partners) Thornton, Marianne Dalhousie Factors influencing adherence to physical activity after transient ischemic attack or nondisabling stroke. MacKay-Lyons, Marilyn J. 5,000 5,000 5,000 5,000 I, II, III, IV Masters-level Scholarship Awardee Institute Project Supervisor(s) Term 10/11 $ Total 10/11 $ Total $ Total $ Theme HSF (All Partners) HSF (All Partners) Hacmon, Revital McGill Dissociated trunk movement and gait performance in patients with chronic stroke. Levin, Mindy F. 4,000 4,000 4,000 4,000 I, II Themes I: Basic Biomedical II: Clinical III: Health Services/Systems IV: Population Health 27

34 Heart and Stroke Foundation Research Report CIHR/HSFC Training Awards in Population Intervention for Chronic Disease Prevention: A Pan-Canadian Program Partners: CIHR; the Propel Centre for Population Health Impact (at the Waterloo); HSF. Total initiative funding: $105,367 Total HSF funding: $75,000 Description: HSF has partnered with the CIHR-funded Propel Centre to support trainee awards in population intervention for chronic disease prevention. The goal of this strategic training program is to increase the capacity for population intervention research in Canada by training students as impact-oriented scientists who work collaboratively across disciplines and sectors to address the most relevant questions using the most appropriate and rigorous methods, to improve population interventions for chronic disease prevention. Doctoral Research Awards Awardee Institute Project Supervisor(s) Term 10/11 $ Total 10/11 $ Total $ Total $ Theme HSF (All Partners) HSF (All Partners) Castonguay, McGill An examination of Sabiston, Catherine 2,000 2,000 2,000 2,000 II, IV Andree physical self-conscious emotions as determinants of physical activity behaviour and stress in adolescent boys and girls. M. Hobin, Erin Association between Manske, Stephen R. 11,650 12,517 11,650 12,517 IV Waterloo adolescent physical activity and the built environment of school neighbourhoods. Olstad, Dana Catalyzing adoption Raine, Kim D. 2,000 2,000 2,000 2,000 IV Alberta and implementation of the Alberta Nutrition Guidelines for children and youth in recreational facilities. Pathammavong, Developing program Manske, Stephen R. 12,000 17,850 12,000 17,850 IV Ratsamy Waterloo theory for Québec en Forme s youth engagement strategy: participatory action research with youth for youth. Pirrie, April Youth overweight and Leatherdale, Scott T. 12,000 17,850 12,000 17,850 III, IV Melissa Toronto obesity and the school environment: expanding our knowledge of contextual influences on this growing problem. Van Hulst, Andraea A. Université de Montréal Features of the social and built environments and adiposity among children. Barnett, Tracie A. 10,250 10,250 10,250 10,250 IV >> 28

35 Heart and Stroke Foundation Research Report Awardee Institute Project Supervisor(s) Term 10/11 $ Total 10/11 $ Total $ Total $ Theme HSF (All Partners) HSF (All Partners) Watts, Allison of British Columbia Adolescent nutritional behaviours: influence of family and school context. Masse, Louise C. 8,750 17,850 8,750 17,850 II, IV Wong, Bonny (Yee Man) Toronto Built Environment and Active Transport (BEAT). Faulkner, Guy E.J. 12,000 17,850 12,000 17,850 IV Master s Studentships Awardee Institute Project Supervisor(s) Term 10/11 $ Total 10/11 $ Total $ Total $ Theme HSF (All Partners) HSF (All Partners) Goodman, Samantha Waterloo Impact of nutrition information on menus. Hammond, David 2,000 4,850 2,000 4,850 IV Vanderlee, Lana Waterloo Impact of regulating nutritional information on menus: evidence to inform policy. Hammond, David 2,350 2,350 2,350 2,350 IV Themes I: Basic Biomedical II: Clinical III: Health Services/Systems IV: Population Health 29

36 Heart and Stroke Foundation Research Report Jump Start Resuscitation Partners: HSF (lead); CIHR Institute of Circulatory and Respiratory Health. Total initiative funding: $203,000 Total HSF funding: $170,000 Description: The aim of this strategic initiative is to build greater capacity for resuscitation research in Canada and to support the next generation of researchers who will contribute to advancing knowledge and improving the quality of patient care and patient outcomes in this important area. Jump Start Resuscitation Research Scholarship Awardee Institute Project Mentor(s) Term 10/11 $ Total 10/11 $ Total $ Total $ Theme HSF (All Partners) HSF (All Partners) Brooks, Steven C. St. Michael's Hospital Assessing public locations at high risk for cardiac arrest in Toronto. Morrison, Laurie J. 50,000 50, , ,000 II, III Jump Start Resuscitation Doctoral Research Award Awardee Institute Project Supervisor(s) Term 10/11 $ Total 10/11 $ Total $ Total $ Theme HSF (All Partners) HSF (All Partners) Andrusiek, Douglas L. of British Columbia EMS system design and response for out of hospital cardiac arrest: the effect of response time and number rescuers. Sheps, Samuel B. 11,000 22,000 33,000 66,000 II, III Jump Start Resuscitation Master s Studentships Awardee Institute Project Supervisor(s) Term 10/11 $ Total 10/11 $ Total $ Total $ Theme HSF (All Partners) HSF (All Partners) Nguyen, Anh Hospital for Mechanisms of Hutchison, James S. 18,500 18,500 18,500 18,500 I Sick Children neuroinflammation following global cerebral ischemia: the role of hypothermia therapy. Thavandiran, Nimalan Toronto Development of a cardiac micro-tissue array bioreactor for electrical stimulation and drug screens using arrhythmogenic and resuscitation models. Radisic, Milica; Zandstra, Peter W. 18,500 18,500 18,500 18,500 I 30

37 Heart and Stroke Foundation Research Report Focus on Stroke Partners: HSF (lead); CIHR Institute of Circulatory and Respiratory Health and Institute of Aging; Canadian Stroke Network. Total initiative funding: $1,255,000 Total HSF funding: $739,833 Description: HSF leads the Focus on Stroke training initiative to support training awards in the area of stroke. This ninth round has been re-focused to build capacity in later pillar research (i.e. clinical, health services/systems, population health) and to encourage more research by health professionals such as those in nursing, medicine, social work, physiotherapy, occupational therapy, speech therapy, or nutrition. Focus on Stroke Research Scholarship Awardee Institute Project Mentor(s) Term 10/11 $ Total 10/11 $ Total $ Total $ Theme HSF (All Partners) HSF (All Partners) Swartz, Richard H. Sunnybrook Health Sciences Centre Intracranial vessel wall imaging with MRI: improving stroke diagnosis and treatment. Black, Sandra E.; Moody, Alan R.; Miklulis, David 38,750 50,000 77, ,000 II, III Focus on Stroke Research Fellowships Awardee Institute Project Supervisor(s) Term 10/11 $ HSF Total 10/11 $ (All Partners) Total $ HSF Total $ (All Partners) Theme Champod, Anne Sophie Dalhousie New approaches to training attentional processes in stroke patients. Chang, Wing Ottawa Induced-pluripotent Yean Hospital stem cells derived from Research Hutchinson-Gilford Institute progeria patients to model vascular disease. Davenport, Effect of cardiovascular Margaret Calgary fitness on cerebrovascular reserve and cognition in older adults. Heidari- Determining the rhythm Mohajerani, of British of post stroke activitydependent Majid Columbia neural repair. Eskes, Gail A.; Klein, Raymond M. 14,167 38,334 31,000 90,000 II, IV Stanford, William L. 40,750 45,000 85,750 90,000 I Poulin, Marc J. 16,250 45,000 46, ,00 I, II, IV Murphy, Timothy H. 37,500 45,000 72,500 90,000 I Huang, En Ottawa The role of Cdk5- mediated APE1 phosphorylation in stroke models. Park, David S. 14,750 45,000 20,750 90,000 I Khacho, Mireille Ottawa Regulation of mitochondrial dynamics to promote brain recovery after stroke. Slack, Ruth S. 37,500 45,000 72,500 90,000 I Kuo, I. fan of British Columbia Antithrombotics in atrial fibrillation: shared decision-making using incremental net-benefit analysis. Lynd, Larry D.; Marra, Carlo A. 45,000 55, , ,000 II, III Themes I: Basic Biomedical II: Clinical III: Health Services/Systems IV: Population Health 31

38 Heart and Stroke Foundation Research Report Focus on Stroke Doctoral Research Awards Awardee Institute Project Supervisor(s) Term 10/11 $ Total 10/11 $ Total $ Total $ Theme HSF (All Partners) HSF (All Partners) Beaudin, Andrew E. Calgary Regulation of cerebral blood flow in obstructive sleep apnea. Poulin, Marc J.; Hanly, Patrick J.V. 3,000 22,000 3,000 66,000 I, II Doan, Ngoc Duc Université du Québec Dévelopement d'analogues sélectifs du recepteur PAC1 pour le traitement de l'ischémie. Fournier, Alain 3,000 22,000 3,000 44,000 I Edwards Barbic, Skye P. McGill Measuring and enhancing emotional vitality in stroke survivors and their caregivers. Mayo, Nancy; Bartlett, Susan J. 10,000 22,000 38,250 66,000 II, III Krasovsky, Tal McGill Arm-leg coordination during gait after stroke. Levin, Mindy F. 18,500 18,500 44,000 44,000 I, II Radlinska, Barbara (Basia) A. Jewish General Hospital White matter integrity in subcortical stroke. Thiel, Alexander 22,000 22,000 66,000 66,000 I, II, III Robertson, Andrew Waterloo Acute influences of exercise and diet on diurnal changes in cerebrovascular function. Hughson, Richard L. 3,000 22,000 3,000 44,000 I, II Rousseaux, Maxime W.C. Ottawa Understanding the neuroprotective function of DJ-1 in models of cerebral ischemia. Park, David S. 7,000 22,000 27,000 44,000 I Wilson, Kenneth Ryan Dalhousie Executive control training: does modality matter? Eskes, Gail A. 6,000 18,500 49,000 66,000 II, III, IV 32

39 Heart and Stroke Foundation Research Report CONTINUING INITIATIVES Research Programs Covert Stroke 2010 Partners: Canadian Stroke Network; HSF. Total initiative funding: $800,000 Total HSF funding: $300,000 Description: Covert stroke is thought to be ten times as common as clinical stroke and may be affecting six percent of the population. This initiative supports research that looks at the prevalence and consequences of covert stroke. The results are expected to inform decision-making on public health policies and planning of clinical trials for the prevention of covert ischemia in Canada. Covert Stroke 2010 Principal Investigator(s) Smith, Eric E.; O'Donnell, Martin J. Institute Project Co-Investigator(s) Term 10/11 $ Total 10/11 $ HSF (All Partners) PURE-MIND: a proposal to determine Calgary the prevalence and consequences of covert ischemia in Canada. Total $ Total $ Theme HSF (All Partners) British Columbia: Lear, Scott A. Ontario: Teo, Koon K.; Wielgosz, Andreas T.; Yusuf, Salim. Québec: Dagenais, Gilles R.; Poirier, Paul. 150, , , ,000 II, III Themes I: Basic Biomedical II: Clinical III: Health Services/Systems IV: Population Health 33

40 Heart and Stroke Foundation Research Report Clinical Imaging Team Grants 2009 Partners: CIHR Institute of Circulatory and Respiratory Health; HSF. Total initiative funding: $4,755,000 Total HSF funding: $1,250,000 Description: This strategic initiative seeks to address the critical steps between technology development and clinical implementation. The aim is to build an integrated platform that brings together Canadian and international strengths in imaging technology, molecular targeting strategies, and policy-relevant outcome trials that examine new, innovative clinical imaging applications. It is anticipated that the program will encourage the identification of novel non-invasive imaging strategies and novel imaging biomarkers, demonstration of their potential through clinical implementation, and evaluation of their diagnostic and prognostic use. HSF co-funds two of the four Team Grants supported through the initiative; both of which are in the area of stroke. Clinical Imaging Team Grants 2009 Principal Investigator(s) Nichol, Helen; George, Graham Sawan, Mohamad Institute Project Co-Investigator(s) Term 10/11 $ Total 10/11 $ HSF (All Partners) CIHR/HSFC team in Saskatchewan synchrotron medical imaging. École A portable wireless near Polytechnique infrared spectroscopy de Montréal system combined with electroencephalography for bedside monitoring of stroke and cardiac patients. Total $ Total $ Theme HSF (All Partners) Saskatchewan: Chapman, Dean; Kelly, Michael; Paterson, Phyllis G.; Pickering, Ingrid; Thomlinson, William; Wiebe, Sheldon. Alberta: Colbourne, Frederick. Ontario: Haacke, Ewart M. USA: Guzman, Raphael , , ,500 2,395,000 I, II Québec: Béland, 125, , ,500 2,360,000 I, II, III, Renée; Denault, André 2015 IV Y.; Deschamps, Alain; Lanthier, Sylvain; Lassonde, Maryse; Lesage, Frédéric; Nguyen, Dang; Tardiff, Jean-Claude. 34

41 Heart and Stroke Foundation Research Report Resuscitation Outcomes Consortium (ROC) Renewal 2009 Partners: US National Institutes of Health - National Heart, Lung and Blood Institute; CIHR Institute of Circulatory and Respiratory Health; HSF. Total initiative funding: $7,667,600 Total HSF funding: $3,000,000 Description: ROC is the first large-scale effort to conduct clinical trials in sudden cardiac arrest and severe traumatic injury focusing on interventions by Emergency Medical Services teams in the field, when there is optimal potential for patient benefit. The goal is to improve survival rates from sudden cardiac arrest and severe traumatic injury. The renewal of the Consortium, through a competitive process, ensures continued support for the ten regional Clinical Centres and one Data and Coordinating Centre in the U.S. and Canada. This is much needed infrastructure for the rapid translation of research advances into improved resuscitation outcomes. HSF co-funds the two Canadian sites listed below. Resuscitation Outcomes Consortium (ROC) Renewal 2009 Principal Investigator(s) Morrison, Laurie J.; Slutsky, Arthur S.; Dorian, Paul Stiell, Ian Institute Project Co-Investigator(s) Term 10/11 $ Total 10/11 $ HSF (All Partners) St. Michael's Toronto regional Hospital resuscitation research out of hospital network. Ottawa ROC Ottawa Hospital OPALS/BC. Research Institute Total $ Total $ Theme HSF (All Partners) Ontario: Black, Sandra E.; Davis, David; Hutchison, James S.; Lavery, James; Redelmeier, Donald A.; Rotstein, Ori D.; Sibbald, William , ,000 1,500,000 3,509,800 I, II, III Ontario: Herbert, Paul 250, ,000 1,500,000 4,157,800 II, III, C.; Osmond, Martin H.; 2015 IV Vaillancourt, Christian; Wells, George A. British Columbia: Abu-Laban, Riyad B.; Christenson, James A.; Macnab, Andrew J.; Russell, James A.; Simons, Richard K.; Sun, Charles Y. Themes I: Basic Biomedical II: Clinical III: Health Services/Systems IV: Population Health 35

42 Heart and Stroke Foundation Research Report Coalitions Linking Action and Science for Prevention (CLASP) 2009 Partners: Canadian Partnership Against Cancer; HSF. Total initiative funding: $2,361,058 Total HSF funding: $250,000 Description: CLASP aims to improve the health of communities and Canadians by bringing together organizations from various provinces and territories and forming coalitions to prevent chronic diseases. The initiative responds to the fact that many aspects of healthy living and a healthy environment can reduce the risk of chronic diseases such as cancer, diabetes, and heart disease. HSF co-funds one project (out of a total of seven). Coalitions Linking Action and Science for Prevention (CLASP) 2009 Principal Investigator(s) Grunfeld, Eva; Manca, Donna Institute Project Co-Investigator(s) Term 10/11 $ Total 10/11 $ HSF (All Partners) Building on Toronto existing tools to improve chronic disease prevention in family practice: the BETTER coalition. Total $ Total $ Theme HSF (All Partners) Ontario: Buchman, Sandy; Carroll, June; Clarkson, David; Dunn, Sheila; Earle, Craig; Glazier, Richard H.; Greiver, Michelle; Hoch, Jeffrey S.; Kahan, Mel; Kaplan, David; Kates, Nick; Kiran, Tara; Krueger, Paul; Levitt, Cheryl; Mamdani, Muhammad M.; Meuser, Jamie; Moineddin, Rahim; Pariser, Pauline; Pasut, George; Salvalaggio, Ginetta; Steele, Leah; Tannenbaum, David; Thorpe, Kevin E.; Upshur, Ross E.G.; Wilson, Lynn. Alberta: Campbell Schere, Denise; Cave, Andrew; Duerksen, Kimberley; Fields, Tony; Halma, Lisa; Klein, Doug; Ludwick, Dave; Mann- Hosford, Lorraine; Shaw, Nicola; Speceley, Shannon; Szafran, Olga. 112, , ,000 2,361,058 II, III, IV 36

43 Heart and Stroke Foundation Research Report Prevention of Cardiovascular and Respiratory Diseases 2009 Partners: CIHR Institute of Circulatory and Respiratory Health; HSF. Total initiative funding: $1,611,538 Total HSF funding: $600,000 Description: The goal of the initiative is to further strengthen Canadian and international health research in the upstream factors leading to chronic cardiovascular, cerebrovascular and respiratory conditions. Proposals approved for funding address the behavioural, psychological, social and environmental factors important in the effective prevention (both primary and secondary) of chronic diseases, and innovative intervention strategies that can affect outcome. HSF co-funds three projects (out of a total of nine). Prevention of Cardiovascular and Respiratory Diseases 2009 Principal Investigator(s) Dolovich, Lisa R.; McDonough, Beatrice A. Janssen, Ian M.; Pickett, William Institute Project Co-Investigator(s) Term 10/11 $ Total 10/11 $ HSF (All Partners) McMaster How does the organization of community-based networks foster screening, prevention and management of blood pressure? Queen's Built environments as a determinant of obesity in young Canadians. Total $ Total $ Theme HSF (All Partners) Ontario: Agarwal, Gina Ragini; Chambers, Larry W.; Liddy, Clare E. 121, , , ,919 III, IV Ontario: Freeman, 126, , , ,707 IV John. McQueen, Matthew J.; Lear, Scott A. McMaster Societal and environmental determinants of lipids as risk factors for cardiovascular disease in 17 countries worldwide. Ontario: Chow, Clara K.; Dehghan, Mahshid; Pogue, Janice M.; Teo, Koon K.; Yusuf, Salim. India: Vaz, Mario. 117, , , ,912 I, II, IV Themes I: Basic Biomedical II: Clinical III: Health Services/Systems IV: Population Health 37

44 Heart and Stroke Foundation Research Report Intervention Research (Healthy Living and Chronic Disease Prevention) 2009 Partners: CIHR Institute of Nutrition, Metabolism and Diabetes and Institute of Circulatory and Respiratory Health; HSF. Total initiative funding: $793,972 Total HSF funding: $200,000 Description: This competition supports prompt initiations of intervention and evaluation research on programs, events, and/or policy initiatives/changes that will impact healthy living and/or chronic disease prevention at the population level. The initiative had five rolling application deadlines throughout the year to facilitate and encourage these rapidly unfolding natural experiments. Intervention Research (Healthy Living and Chronic Disease Prevention) 2009 Principal Investigator(s) Bégin, Catherine McGavock, Jonathan Shah, Baiju R. Institute Project Co-Investigator(s) Term 10/11 $ Total 10/11 $ HSF (All Partners) Université Dissemination of the Laval "Choisir de Maigrir?" program in health and social service centers in Québec: evaluation of its implementation and impact on lifestyle habits and well-being. Natural experiment: Manitoba investigating Manitoba's new policy for physical education for secondary students. Sunnybrook Evaluation of a Health strategy to improve Sciences cardiovascular disease Centre screening and treatment for people with diabetes. Québec: Mongeau, Lyne; Paquette, Marie-Claude. Ontario: Provencher, Véronique. Manitoba: Griffith, E. Jane. Alberta: Veugelers, Paul J. Ontario: Hobin, Erin; Manske, Stephen R. Prince Edward Island: Murnaghan, Donna Ann. Ontario: Bhattacharyya, Onil; Blumer, Ian; Cheng, Alice; Mamdani, Muhammad M.; Parsons, Janet A.; Straus, Sharon E.; Yu, Catherine; Zwarenstein, Merrick F. Total $ Total $ Theme HSF (All Partners) 100, , , ,163 IV 50, ,000 50, ,000 III, IV 50,000 99,853 50, ,809 III, IV 38

45 Heart and Stroke Foundation Research Report Secondary Stroke Prevention Health Services and Care Team Grants 2009 Partners: HSF (lead); Canadian Stroke Network; CIHR Institute of Circulatory and Respiratory Health. Total initiative funding: $1,797,967 Total HSF funding: $1,197,967 Description: This strategic initiative seeks to advance the goals of the Canadian Stroke Strategy, by funding research that examines how to improve the timely delivery of secondary stroke prevention services and care that will ensure optimal outcomes for patients. Secondary Stroke Prevention Health Services and Care Team Grants 2009 Institute Project Co-Investigator(s) Term 10/11 $ Total 10/11 $ HSF (All Partners) Alberta Stroke of Calgary Prevention in TIAs and mild strokes (ASPIRE). Dalhousie Program of Rehabilitative Exercise and Education to avert Vascular Events after Non-disabling stroke or Transient ischemic attack (PREVENT trial). Vancouver A natural experiment Island in rapid TIA care with Health knowledge transfer Authority and exchange. Alberta: Butcher, Ken S.; Demchuk, Andrew M.; Edmond, Cathy; Majumdar, Sumit R.; Shuaib, Ashfaq; Watson, Timothy J. Nova Scotia: Bedard, Richard J.; Blanchard, Chris M.; Corning, Corinne; DeWolfe, Judy M.; Eskes, Gail A.; Firth, Wanda; Giacomantonio, Nicholas B.; MacKay, Michelle; Maharaj, Mandat; Manley, Sarah; Marsters, David; Skedgel, Chris; Thompson, Kara; Wightman, Howard. British Columbia: Harris, Devin R. Total $ Total $ Theme HSF (All Partners) Principal Investigator(s) Coutts, Shelagh B.; Jeerakathil, Thomas J. MacKay- Lyons, Marilyn J.; Gubitz, Gordon J. Penn, Andrew M. W.; Maclure, Malcolm , , , ,046 II, III 132, , , ,146 II, III , , , ,775 II, III, IV Vascular Cognitive Impairment 2009 Partners: Canadian Stroke Network; HSF. Total initiative funding: $499,996 Total HSF funding: $499,996 Description: Projects supported through this initiative are multidisciplinary and have the potential to impact changes in clinical practice and significantly advance knowledge in the area of vascular cognitive impairment as it relates to small vessel disease and covert strokes. HSF funds one of the four team grants. Vascular Cognitive Impairment 2009 Institute Project Co-Investigator(s) Term 10/11 $ Total 10/11 $ HSF (All Partners) Role of exercise of British in cognition and Columbia function in seniors with vascular cognitive impairment. Total $ Total $ Theme HSF (All Partners) Principal Investigator(s) Liu-Ambrose, Teresa; Boyd, Lara A.; Eng, Janice J. Hsiung, Ging- Yuek R. British Columbia: Brasher, Penelope M.A.; Feldman, Howard H.; Jacova, Claudia; Lee, Philip. 123, , , ,996 I, II Themes I: Basic Biomedical II: Clinical III: Health Services/Systems IV: Population Health 39

46 Heart and Stroke Foundation Research Report Applied Public Health Chair 2008 Partners: CIHR Institute of Population and Public Health; Public Health Agency of Canada; Centre de recherche pour la prévention de l obésité; HSF. Total initiative funding: $925,000 Total HSF funding: $462,500 Description: The Applied Public Health Chair platform supports population health interventions that address major risk factors for chronic diseases such as heart disease, stroke, diabetes, obesity, and their underlying determinants. Focusing on community/societallevel factors (individual, social, cultural, economic, environmental) and their interactions, the program aims to prevent disease and promote and improve the health of society as a whole. The specific objectives are to fund high quality policy and program interventions; to foster formal linkages with the public health system; and to support mentorship, education, and knowledge translation activities. HSF is co-funding one Applied Public Health Chair in the area of obesity. Applied Public Health Chair 2008 Principal Investigator(s) Raine, Kim D. Institute Project Co-Investigator(s) Term 10/11 $ Total 10/11 $ HSF (All Partners) Environmental and of Alberta population-based strategies for chronic disease prevention and the promotion of healthy weights. Total $ Total $ Theme HSF (All Partners) N/A , , , ,000 IV Childhood Obesity Prevention and Treatment Operating Grants 2008 Partners: CIHR Institute of Nutrition, Metabolism and Diabetes and Institute of Human Development, Child and Youth Health; Canada s Research-based Pharmaceutical Companies Health Research Foundation (Rx&D); HSF. Total initiative funding: $666,508 Total HSF funding: $195,110 Description: The primary objective of this funding opportunity is to strengthen research and translate knowledge into effective interventions to prevent and treat childhood obesity. HSF is co-funding two of the five team grants. Childhood Obesity Prevention and Treatment Operating Grants 2008 Principal Investigator(s) Muhajarine, Nazeem; Neudorf, Cordell O. von Tigerstrom, Barbara Joanne Institute Project Co-Investigator(s) Term 10/11 $ Total 10/11 $ HSF (All Partners) Working upstream: Saskatchewan effecting healthy children through neighbourhood design. Awareness, use Saskatchewan and impact of the children's tax credit. Total $ Total $ Theme HSF (All Partners) Saskatchewan: Baxter- Jones, Adam Dominic; Bell, Scott; Chad, Karen E.; Green, Kathryn; Holden, William J.; Sherar, Lauren. Nova Scotia: Kirk, Sara F.L , , , ,624 III, IV Saskatchewan: Chad, Karen ,439 74,878 49, ,884 IV E.; Larre, Tamara; Reeder, Bruce. Ontario: Cameron, Christine; Mawani, Amin; Tremblay, Mark S. 40

47 Heart and Stroke Foundation Research Report Intervention Research (Healthy Living and Chronic Disease Prevention) 2008 Partners: CIHR Institute of Nutrition, Metabolism and Diabetes; Canadian Population Health Initiative; HSF. Total initiative funding: $280,709 Total HSF funding: $100,000 Description: This competition supports prompt initiations of intervention and evaluation research on programs, events, and/or policy initiatives/changes that will impact healthy living and/or chronic disease prevention at the population level. The initiative had five rolling application deadlines throughout the year to facilitate and encourage these rapidly unfolding natural experiments. HSF is supporting one of the five projects from the June 2008 competition. Intervention Research (Healthy Living and Chronic Disease Prevention) 2008 Principal Investigator(s) Veugelers, Paul J. Institute Project Co-Investigator(s) Term 10/11 $ Total 10/11 $ HSF (All Partners) Economic evaluation of Alberta of a school-based program for the prevention of childhood obesity. Total $ Total $ Theme HSF (All Partners) Alberta: Jamieson, Stewart; ,000 82, , ,709 IV Johnson, Jeffrey A.; Ohinmaa, Arto E. Built Environment, Obesity and Health 2007 Partners: HSF (lead); CIHR Institute of Aging; Institute of Circulatory and Respiratory Health; Institute of Human Development, Child and Youth Health; Institute of Musculoskeletal Health and Arthritis; Institute of Nutrition, Metabolism and Diabetes; Institute of Population and Public Health. Total initiative funding: $4,071,477 Total HSF funding: $1,479,097 Description: This unique initiative encourages collaborative, horizontal teams of researchers, urban planners, government and nongovernmental organizations to conduct policy-relevant research to explore how the built environment influences our health and well-being. Built Environment, Obesity and Health 2007 Principal Investigator(s) Barnett, Tracie A. Berry, Tanya R. Institute Project Co-Investigator(s) Term 10/11 $ Total 10/11 $ HSF (All Partners) Ste-Justine Features of the Hospital built environment in residential neighbourhoods that influence excess weight and weightrelated behaviours in a cohort of children at risk for obesity. A longitudinal of Alberta examination of the relationship between the built environment, physical activity, and social factors within the Capital Health Region of Alberta. Québec: Apparicio, Philippe; Brice, Stéphane; 2010 Daniel, Mark; Gauvin, Lise; Kestens, Yan; Koushik, Anita; Lambert, Marie; McGrath, Jennifer J.; Mongeau, Lyne; Valois, Pascale. Alberta: Edwards, Joy; Nykiforuk, Candace; Predy, Gerald; Spence, John C. Nova Scotia: Blanchard, Christopher. Total $ Total $ Theme HSF (All Partners) 11,543 16, , ,986 II, III, IV 1,000 42,411 42, ,418 IV >> Themes I: Basic Biomedical II: Clinical III: Health Services/Systems IV: Population Health 41

48 Heart and Stroke Foundation Research Report Principal Investigator(s) Faulkner, Guy E.J.; Buliung, Ronald N. Institute Project Co-Investigator(s) Term 10/11 $ Total 10/11 $ Total $ HSF (All Partners) HSF of Toronto Built Environment and Active Transport (BEAT). Ontario: Adlaf, Edward M.; Fusco, Caroline; Howard, Donna; Kennedy, Jacky; Salmon, Art. Total $ Theme (All Partners) ,000 23,940 38, ,435 IV 2010 Frank, Lawrence D. of British Columbia Built environment influences on diet, physical activity, and obesity: a transdisciplinary approach. Alberta: Raine, Kim D. Ontario: Cameron, Roy; Fisher, Patrick D.; Thompson, Mary E ,000 83, , ,000 IV Lyons, Renée F.; Grant, Jill L. Dalhousie Optimizing investments in the built environment to reduce adolescent obesity. Nova Scotia: Arthur, Michael H.; Blanchard, Chris; Chircop, Andrea M.; Dummer, Trevor J.; Kirk, Sara F.L.; Manuel, Patricia M.; Parker, Louise; Pitter, Robert; Rehman, Laurene A.; Shields, Christopher A. Ontario: Rainham, Daniel G.C ,575 83, , ,492 III, IV Nykiforuk, Candace I.J. of Alberta Obesity prevention and the built environment: examining opportunities and barriers in four Alberta communities. Alberta: Plotnikoff, Ronald C.; Raine, Kim D.; Schopflocher, David; Spence, John C. Vallianatos, Helen , , ,397 III, IV Spence, John C. of Alberta A longitudinal study of environmental determinants of overweight among children: the SHAPES of things to come. Alberta: Ball, Geoof D.C.; Predy, Gerald N.; Veugelers, Paul J. British Columbia: Frank, Lawrence D.; Boule, Normand ,684 78, , ,107 IV Teschke, Kay E. of British Columbia Bicyclists' Injuries and the Cycling Environment (the BICE study). British Columbia: Babul, Shelina; Becker, Jack; Brubacher, Jeff; Cripton, Peter; Fenton, Bonnie; Harris, Anne; Hay, David; Hunte, Garth; Mulpuri, Kishore; Reynolds, Conor Stary, Peter. Ontario: Chipman, Mary; Cusimano, Michael; Friedman, Steven; Tomlinson, David; Wentworth, Barbara ,648 82, , ,379 IV 42

49 Heart and Stroke Foundation Research Report Cardiovascular Complications of Diabetes 2007 Partners: CIHR Institute of Circulatory and Respiratory Health and Institute of Nutrition, Metabolism and Diabetes; Canadian Diabetes Association; Pfizer Canada Inc.; HSF. Total initiative funding: $3,372,776 Total HSF funding: $650,000 Description: This program focuses on the production of new knowledge and the translation of research findings, at the interface between the diabetes and the cardiovascular research communities, into improvements in the health care systems and the health of the populations. HSF co-funds two High Risk Seed Grants which have completed and one Team Grant. Team Grant Principal Investigator(s) Petrella, Robert J. Institute Project Co-Investigator(s) Term 10/11 $ Total 10/11 $ HSF (All Partners) London Innovation to reduce Health cardiovascular complications of diabetes Sciences Centre at the intersection of discovery, prevention and knowledge exchange. Total $ Total $ Theme HSF (All Partners) Reducing Health Disparities and Promoting Equity for Vulnerable Populations - Interdisciplinary Capacity Enhancement (ICE) Team Grants 2006 Partners: CIHR Institute of Gender and Health and Institute of Circulatory and Respiratory Health; HSF. Total initiative funding: $704,792 Total HSF funding: $249,755 Description: Interdisciplinary Capacity Enhancement (ICE) grants provide support for new or existing multidisciplinary groups. These grants enable teams to build capacity, add expertise to their core competencies, and develop strategies for knowledge translation. This targeted investment is expected to lead to understanding of health disparities and addressing these disparities to improve the health status of vulnerable populations. HSF co-funds one project listed below. Ontario: Harris, Stewart B.; Holdsworth, David W.; Shoemaker, J. Kevin ; Stewart, Moira. Finland: Tikkanen, Heikki , , ,000 2,799,530 I Reducing Health Disparities and Promoting Equity for Vulnerable Populations - Interdisciplinary Capacity Enhancement (ICE) Team Grants 2006 Principal Institute Project Co-Investigator(s) Term 10/11 $ Total 10/11 $ Total $ Total $ Theme Investigator(s) HSF (All Partners) HSF (All Partners) Grace, Sherry L.; Stewart, Donna E. Health Network Cardiovascular secondary prevention for vulnerable population: an interdisciplinary approach to improving access to services and outcomes. Ontario: Alter, David A.; Anand, Sonia S.; Bunker, Steve; Harvey, Paula J.; Holder, Glenn; Kaur, Rimmy; Oh, Paul; Rukholm, Ellen E.; Rush, James Walter E.; Scholey, Patricia E.; Williamson, Karen M , , , ,792 III Themes I: Basic Biomedical II: Clinical III: Health Services/Systems IV: Population Health 43

50 Heart and Stroke Foundation Research Report Genomic Medicine and Human Development 2005 Partners: CIHR Institute of Genetics; Institute of Circulatory and Respiratory Health; Institute of Human Development, Child and Youth Health; HSF. Total initiative funding: $2,382,246 Total HSF funding: $600,000 Description: These operating grants support projects that bridge clinical investigation and basic research to strengthen the study of human development. HSF co-funds one project listed below. Genomic Medicine and Human Development 2005 Principal Investigator(s) Andelfinger, Gregor U.; Nemer, Mona; Richter, Andrea M.; Rozen, Rima. Institute Project Co-Investigator(s) Term 10/11 $ Total 10/11 $ HSF (All Partners) Ste-Justine Genetic determinants Hospital of congenital heart disease. Total $ Total $ Theme HSF (All Partners) Québec: Bigras, Jean-Luc; , , ,000 2,382,246 I, II, IV Dubé, Marie-Pierre; Khairy, 2010 Paul. 44

51 Heart and Stroke Foundation Research Report Training Programs Focus on Stroke Partners: HSF (lead); Canadian Stroke Network; CIHR Institute of Circulatory and Respiratory Health and Institute of Aging. Total initiative funding: $535,100 Total HSF funding: $323,650 Description: HSF leads the Focus on Stroke training initiative to support training awards in the area of stroke. This eighth round has been re-focused to build capacity in later pillar research (i.e. clinical, health services/systems, population health) and to encourage more research by health professionals such as those in nursing, medicine, social work, pharmacology, pathology, physiotherapy, occupational therapy, speech therapy, or nutrition. Focus on Stroke Research Fellowships Awardee Institute Project Supervisor(s) Term 10/11 $ Total 10/11 $ Total $ Total $ Theme HSF (All Partners) HSF (All Partners) Burton, St. Michael's An economic assessment of the Laupacis, 43,750 55,000 98, ,000 II, III Kirsteen Hospital appropriateness of diagnostic imaging use in patients with acute, ischemic stroke. Andreas Dlamini, Hospital for Alleviating neonatal cerebral venous deveber, 40,250 55,000 77, ,000 II, III Nomazulu Sick Children outflow obstruction and thrombosis with a custom-designed pillow. Gabrielle A.; Shroff, Manohar M. Sangani, Samir McGill Relationship between spasticity and voluntary motor control in the upper limb post-stroke. Feldman, Anatol 17,250 45,000 62,250 90,000 I, II Focus on Stroke Doctoral Research Awards Awardee Institute Project Supervisor(s) Term 10/11 $ Total 10/11 $ Total $ Total $ Theme HSF (All Partners) HSF (All Partners) Querido, Can hyperoxia enhance the Sheel, 20,900 22,000 42,900 66,000 I, II Jordan of British Columbia baroreflex in patients with obstructive sleep apnea? Andrew W. Subramanian, McGill Motor learning in stroke - role of Levin, Mindy 1,000 22,000 2,000 44,000 I, II Sandeep explicit information. F. Thornton, Marianne Dalhousie Factors influencing adherence to physical activity after transient ischemic attack or non-disabling stroke. MacKay- Lyons, Marilyn J.; Blanchard, Chris M. 22,000 22,000 40,500 40,500 I, II, III, IV Themes I: Basic Biomedical II: Clinical III: Health Services/Systems IV: Population Health 45

52 Heart and Stroke Foundation Research Report Focus on Stroke Partners: HSF (lead); Canadian Stroke Network; CIHR Institute of Circulatory and Respiratory Health and Institute of Aging. Total initiative funding: $1,221,386 Total HSF funding: $854,861 Description: HSF leads the Focus on Stroke training initiative to support Research Fellowships and Doctoral Research Awards in the area of stroke. The primary objectives are to increase stroke research capacity in Canada and to address the shortage of highly qualified personnel working in this important area. Focus on Stroke Research Fellowships Awardee Institute Project Supervisor(s) Term 10/11 $ Total 10/11 $ Total $ Total $ Theme HSF (All Partners) HSF (All Partners) Acerra, Promoting stroke recovery via Boyd, Lara ,050 16,667 93, ,000 I, II Nicole of British Columbia somatosensory cortex stimulation. A Cook, Douglas J. Toronto Western Hospital Establishing a preclinical model of stroke in non-human primates. Tymianski, Michael ,000 93, ,000 I, II Focus on Stroke Doctoral Research Awards Awardee Institute Project Supervisor(s) Term 10/11 $ Total 10/11 $ Total $ Total $ Theme HSF (All Partners) HSF (All Partners) Fingas, Matthew S. of British Columbia Determining the timing and mechanism of stroke rehabilitation at the level of individual synapses in vivo. Murphy, Timothy H ,992 38,792 I 46

53 APPENDIX B NATIONAL PERSONNEL AWARDS Photo: Dr. Gavin Oudit ( Alberta) was the recipient for the HSFC McDonald Scholarship and the HSFC Distinguished Clinician Scientist awards.

54 Heart and Stroke Foundation Research Report Doctoral Research Awards Awardee Supervisor(s) Institute Project Keywords Term $ Total $* Theme Altimimi, Haider F. Stellwagen, David McGill Mechanism of tumor necrosis factor alpha induced neuronal glutamate excitotoxicity. Stroke, neurophysiology, neuroinflammation. Audet, Martin Bouvier, Université de Beta-blockers: exploring the GPCR, pharmacology, Michel Montréal structural determinant for beta-blockers, ligandbiased ligand-biased signalling. efficacies, structural determinants. Basseri, Sana Austin, St. Joseph's Understanding the role of Lipids, adipogenesis, ER Richard C. Hospital ER stress in adipogenesis stress, obesity. and diet-induced obesity. Bowden, Kristin Francis, Cholesteryl ester storage High density lipoproteins, Gordon A. of British disease as a model for lipid metabolism, Columbia understanding intracellular intracellular cholesterol cholesterol homeostasis and transport, ATP-binding HDL biogenesis. casette transporter A1, lysosomal acid lipase. Chaudhary, Ketul Seubert, Role of B-type Fatty acids, myocardial John M. Alberta natriuretic peptide in ishemia, epoxyeicostrienoic epoxyeicosatrienoic acid acids, cardioprotective mediated cardioprotection. signaling, B-type natriuretic peptide. Chen, Wenqian Chen, S. R. Ryanodine receptor Cardiac arrhythmias and Wayne Calgary regulation by luminal Ca2+ sudden death, ryanodine and its role in heart disease. receptor, genetic mutations, Ca2+ alternans, transgenic animal model. Declercq, Vanessa Zahradka, Peter; Taylor, Carla G. Manitoba Conjugated linoleic isomers regulate blood pressure through modulation of adipose tissue function. Blood pressure, adipose tissue, conjugated linoleic acid, angiotensin, adinopectin. Dissing-Olesen, MacVicar, Astrocyte toll-like receptor Ischemic stroke, astrocytes, Lasse Brian A. of British 3 induces glutamate toll-like receptor 3, Columbia neurotoxicity during neurotransmission, and ischemic stroke. neuroinflammation. Dragert, Katie Zehr, E. Paul Efficacy of phased resistance Neural plasticity, reflex Victoria training to stabilize ankle modulation, neuromuscular muscle strength after stroke. adaptation, motor recovery, rehabilitation. 21,000 63,000 I 21,000 42,000 I 21,000 42,000 I 21,000 63,000 I 21,000 38,500 I ,000 63,000 I 3,500 24,500 I 21,000 63,000 I 21,000 63,000 I,II Eguchi, Megumi Sweeney, York Regulation of cardiomyocyte Heart failure, apoptosis, ,000 63,000 I Gary apoptosis by adiponectin. obesity, adiponectin. Feric, Nicole Koschinsky, Marlys L. Queen's Interaction of lipoprotein (a) with the plasminogen system: mechanisms and pathophysiological consequences. Lipoprotein (a); plasminogen activation; fibrin clot architecture; fibrinolysis; atherothrombosis. 21,000 42,000 I * Amount shown represents stipend value only. 48

55 Heart and Stroke Foundation Research Report Rueda-Clausen, Christian F. Davidge, Sandra T. Alberta Effects of hypoxia-induced intrauterine growth restriction on cardiac function and metabolism in adult offspring. Fetal, hypoxia, cardiac, metabolism, ischemia/ reperfusion. Sage, Michael D. McIlroy, Aerobic exercise as an Stroke, rehabilitation, William E.; Toronto adjunct to upper-limb neuroplasticity, upper limb, Roy, Eric A. therapy for recovery from neurophysiology. stroke. Sider, Krista Lynn Simmons, Calcific aortic valve sclerosis Calcific aortic valve Craig A. Toronto progression - associated sclerosis, biomechanics, matrix spatial and temporal micropipette aspiration, changes. histology, mechanobiology. Szewczyk, Grover, McMaster Plasma membrane Ca2+ Calcium homeostasis, Magdalena M. Ashok K. pump isoforms in arteries: cell signaling, plasma search for selective membrane calcium pumps, inhibitors. drug discovery, coronary artery. Awardee Supervisor(s) Institute Project Keywords Term $ Total $* Theme Haddad, Paola Rivard, Alain Université de Rôle de la NADPH oxydase Néovascularization, 21,000 42,000 I Montréal dans la néovacularisation post-ischémique et l'athérosclérose. ischémie, stress oxydant, athérosclérose, NADPH oxydase. Imm, Joon-Hyuk Wang, Yu The roles of beta-arrestin in Synaptic plasticity, betaarrestin, 21,000 63,000 I Tian of British Columbia NMDAR-mediated neuronal death in ischemia. AMPA receptors, ischemia, receptor trafficking. Lee, Brian L. Sykes, Brian D.; Fliegel, Larry Alberta NMR structural studies of transmembrane fragments of NHE1. NMR, membrane proteins, protein structure, NHE1. 21,000 63,000 I Linte, Cristian A. Peters, Terence M. Robarts Research Institute Techniques for image guidance and navigation of minimally invasive off-pump intra-cardiac interventions. Minimally-invasive cardiac interventions, imageguided surgery and therapy, pre-operative procedure planning, virtual reality augmentation, intraoperative guidance and navigation ,500 42,000 I,II,III,IV Parsons, Matthew Hirasawa, Memorial KATP channel regulation of Obesity, homeostasis, 18,666 39,666 I,II,IV Michiru Newfoundland orexin neurons. hypothalamus, orexin, electrophysiology. Ramer, Leanne Krassioukov, Andrei V.; Steeves, John of British Columbia The role of peripheral plasticity in episodic hypertension following spinal cord injury. Autonomic dysreflexia, blood pressure, sympathetic neurons, sensory neurons, spinal cord injury ,500 42,000 I ,000 63,000 I,II,IV 17,500 63,000 I ,500 21,000 I 21,000 21,000 I Themes I: Basic Biomedical II: Clinical III: Health Services/Systems IV: Population Health 49

56 Heart and Stroke Foundation Research Report Awardee Supervisor(s) Institute Project Keywords Term $ Total $* Theme Thackeray, James DaSilva, Jean Impact of glycaemic Type II diabetes, diabetic 21,000 42,000 I N; Beanlands, Rob S.B. Ottawa Heart Institute therapy in progression and regression of diabetic heart disease. cardiac disease, PET imaging, [11C]metahydroxyephedrine, glycaemic therapy. Thorn, Stephanie DaSilva, Jean Pathophysiological Cardiovascular metabolism, 21,000 42,000 I N.; Gollob, Michael H. Ottawa Heart Institute mechanism of the human Arg302GIn-PRKAG2 mutation-induced metabolic cardiomyopathy. glycogen storage disease, glucose metabolism, PRKAG2, cardiac imaging. Torbey, Sami Akl, Selim Queen's Risk stratification for sudden Electrophysiology, signal 21,000 63,000 II G.; Redfearn, Damian Paul P. cardiac death through analysis of the paced QRS complex. processing, sudden cardiac death, risk stratification, pacing. Tran, Cam Ha T. Welsh, Cell-to-cell communication Gap junctions, 21,000 42,000 I Donald G. Calgary in small resistance arteries. smooth muscle cells, electrophysiology, microcirculation, conduction. Tyrrell, Pascal N. Silverman, Earl D. Hospital for Sick Children Inflammation and atherosclerosis in pediatric rheumatic disease. Atherosclerosis, lipid, rheumatic disease, children, epidemiology ,000 63,000 II Voronova, Anastassia Skerjanc, Ilona S. Ottawa Characterization of Gli2 transcription factor in cardiac muscle cell development. Stem cells, cardiomyogenesis, transcription factor networks, protein-protein interactions, massspectrometry. Xiang, Fuli Feng, Regulation of cardiac Stem cell factor, myocardial Qingping of Western function by stem cell factor infarction, cardiac repair, Ontario post myocardial infarction. stem cell, angiogenosis. Zhang, Yan Suuronen, PET imaging for the Stem cells, tissue Erik J; Ruel, Ottawa Heart assessment of transplanted engineering, angiogenesis, Marc Institute progenitor cells delivered in ischemia, imaging. biomatrices. Zhao, Ruogang Simmons, Biomechanical regulation Aortic valve sclerosis, Craig A. Toronto of apoptosis in aortic valve apoptosis, endoplasmic interstitial cells. reticulum, calcium signaling, cytoskeleton deformation ,000 63,000 I 21,000 63,000 I 21,000 45,500 I 7,875 28,875 I * Amount shown represents stipend value only. 50

57 Heart and Stroke Foundation Research Report Research Fellowships Awardee Supervisor(s) Institute Project Keywords Term $ Total $* Theme Briet, Marie Schiffrin, Jewish General Remodelage des artères Hypertension, artère, 40, ,000 I, II Ernesto L.; Lipman, Mark L. Hospital de petit et gros calibre dans l'insuffisance rénale chronique. insuffisance rénale, remodelage vasculaire, rigidité artérielle. Brodeur, Mathieu Moreau, Université de Implication du CD36 Acides gras, calcification, 40,000 80,000 I Pierre Montréal dans la prévention de l'élastocalcinosis. CD36, hypertension. Brunt, Keith Li, Ren-Ke Toronto Rejuvenation of human Aging, stem cells, 40,000 80,000 I Russell General Hospital circulating progenitor cells for enhanced cell therapy in ischemic cardiomyopathy. rejuvenation, neovascularization, cardiomyopathy. Castro, Michele Schulz, Matrix metalloproteinase-2 Metalloproteinases, 40,000 80,000 I M. Richard Alberta (MMP-2) mediated-vascular dysfunction in septic shock: role of calponin. calponin, endotoxemia, vascular dysfunction, vascular smooth muscle cells. Chan, Allen W. Wang, Yu Role of the NMDA receptors Stroke, NMDAR, in vivo, 40,000 80,000 I, II Tian; Murphy, Timothy H. of British Columbia in recovery of dendritic structure after stroke. dendrites, two-photon. Chruscinski, Levy, Gary; Toronto Antibodies in heart transplantation: Heart transplant, 50, ,000 I, II Andrzej J. Ross, Heather J General Hospital profiling with antigen microarrays. rejection, transplant vasculopathy, antibody, immunosupression. Clark, Darren L. Tuor, Ursula I. Potential modes of action of Resveratrol, recurrent 40,000 80,000 I Calgary resveratrol neuroprotection. stroke, neuroprotection, mechanism, nutrition. Dekker, Mark J. Adeli, Hospital for Hepatic overproduction of Lipoprotein B, 40,000 80,000 I, II Khosrow Sick Children lipoprotein B-100/VLDL in insulin resistance. hyperlipidemia, triacylglyceride, cardiovascular disease, insulin. Dey, Bijan Kumar Dutta, Investigating micrornas as Cardiac hypertrophy, heart, 40,000 80,000 I Anindya Virginia novel regulators of cardiac hypertrophy. microrna, expression, mutant mouse. Dou, Ying Fedida, David Potassium channel Potassium channel, 40,000 80,000 I of British Columbia trafficking in adult cardiac myocytes. electrophysiology, transfection, cardiomyocyte, trafficking. Farkas, Attila S. Nattel, Montreal Heart The role of intracellular Isolated heart, arrhythmia, ,000 80,000 I Stanley Institute Ca2+ abnormalities in the development of torsade de pointes in isolated rabbit hearts. Ca transient, Ca handling, torsades de pointes. Filion, Kristian B. Luepker, Russell V. Minnesota Trends in smoking and smoking-related behaviors: the Minnesota heart survey. Smoking, tobacco, trends, epidemiology, cardiovascular biomarkers. 40,000 40,000 II, IV Themes I: Basic Biomedical II: Clinical III: Health Services/Systems IV: Population Health 51

58 Heart and Stroke Foundation Research Report Hughes, Michael R. McNagny, Kelly M. of British Columbia Molecular mechanisms regulating vascular development, repair and function. CD34, adhesion, vascular permeability, cell migration, vascular repair. Jantzie, Lauren L. Jensen, Children's Glutamate receptor Hypoxia-ischemia Frances E. Hospital anatagonism and neonatal periventricular Boston hypoxia-ischemia. leukomalacia, glutamate receptors, memantine, topiramate. Jaumouillé, Grinstein, Hospital for Role of surface charge in the Ischemia-reperfusion Valentin T. J. Sergio Sick Children Na+/H+ exchanger NHE1 injury, Na+/H+ exchanger, topology and activity. ph homeostasis, surface charge, electrostatic interaction. Jegatheeswaran, McCrindle, Hospital for Creating a validated risk Cardiac surgery, Anusha Brian W. Sick Children score to predict outcomes congenital heart disease, following congenital cardiac epidemiology, intensive surgery. care, risk modeling. Johnson, Rosalyn Michel, Brigham and Regulation of AMPK and Diabetes, oxidative stress, P. Thomas Women's its substrates in endothelial endothelial nitric oxide Hospital cells during oxidative stress. synthase, angiogenesis, AMP-activated protein kinase. Awardee Supervisor(s) Institute Project Keywords Term $ Total $* Theme Han, Huili MacVicar, Novel mechanisms Stroke, NMDA receptor, 40, ,000 I Brian A. of British Columbia underlying glutamate release during ischemia. glutamate release, ischemic depolarization, neuroprotection. Hannan, Johanna Webb, R. Medical The inhibition of RhoA/ Sexual dysfunction, nitric ,907 79,907 I L. Clinton College of Georgia Rho-kinase by nitric oxide in erectile function in rats. oxide, RhoA/Rho-kinase, hypertension. Hegle, Andrew Accili, Eric A. Glycosylation and Pacemaker, ion ,000 80,000 I of British Columbia subunit assembly of hyperpolarization-activated cyclic nucleotide-gated (HCN) pacemaker channels. channels, glycosylation, heteromerization, electrophysiology. Hines, Dustin J. Haydon, Tufts Astrocytic modulation of Astrocyte, adenosine, 40,000 80,000 I, II Philip ischemic infarct size and recovery from stroke. stroke, two-photon microscopy, behavior. Hoi, Yiemeng Steinman, Carotid flow waveforms: Atherosclerosis, waveform, 40,000 50,000 I, II David A. Toronto potential interactions between systemic and local atherosclerosis risk factors. stroke, blood flow dynamics, carotid artery. Huang, Xi-Ping Weisel, Richard D. Toronto General Hospital Harnessing the immune system to enhance allogenic cell transplantation in myocardial restoration. Myocardial infarction, cell transplantation, stem cells, bone marrow mesenchymal cells, immune regulation. 40,000 80,000 I 40,000 80,000 I 40,000 80,000 I, II 40,000 80,000 I , ,000 II 20,000 60,000 I * Amount shown represents stipend value only. 52

59 Heart and Stroke Foundation Research Report Awardee Supervisor(s) Institute Project Keywords Term $ Total $* Theme Kandasamy, Arulmozhi D. Dyck, Jason R.B. Alberta Regulation of glycogen synthase kinase-3 beta by matrix metalloproteinase-2 during ischemic reperfusion injury of the heart. Matrix metalloproteinases, heart failure, ischemiareperfusion, oxidative stress, apoptosis. Kaun, Karla R. Heberlein, The genetics of alcoholism: Addiction, alcoholism, Ulrike California San genetic, molecular, and genes, neural mechanisms, Francisco neuroanatomical dissection fruit flies. of ethanol addiction in drosophila melanogaster. Khajoee, Vahid Yeung, Rae Hospital for The role of inositol Kawasaki, cardiovascular, S.M. Sick Children 1,4,5-triphosphate kinase C superantigen, inositol in pathogenesis of Kawasaki 1,4,5-triphosphate kinase C. disease. Khan, Aarlenne Munoz, Queen's The role of attention in Reaching, attention, motor Douglas P.; visually-guided movements. learning, optic ataxia, Flanagan, neglect. John R. Lachance, Des Rosiers, Institut de Potentiel thérapeutique de Diabète, fonction Dominic Y. Christine; cardiologie de la signalisation du cgmp cardiaque, métabolisme, Deschepper, Montréal dans la cardiomyopathie lipotoxicité. Christian F. diabétique. Mani, Sarathi Wang, Rui Lakehead Mitochondrial production Hydrogen sulfide, heart, and function of hydrogen mitochondria, ischemia, sulfide. oxidative stress. Mason, Rosemarie D. Randolph, Gwendalyn Mount Sinai Medical Center Design and immunogenecity testing of an atherosclerosis vaccine. Atherosclerosis, vaccine, peptide, T cell, monocyte. Merlen, Allen, Bruce Montreal Heart Functional studies of Cardiac hypertrophy, Clémence G. Institute the ETB in the nuclear endothelin, receptors, membrane. nucleus, G protein. Michael, Nattel, Montreal Heart Calcium handling Arrythmia, Georghia Stanley; Institute abnormalities and the calcium, mapping, Comtois, induction of atrial fibrillation electrophysiology. Philippe in heart failure. Nair, Nanthakumar, Transmural activation in Ventricular fibrillation, Krishnakumar Kumaraswamy Health human ventricular fibrillation. transmural, reentry, human, Network ventricle. Natarajan, Rossi, Fabio Role of macrophages in Muscle, repair, Anuradha M.V. of British regulating regeneration and regeneration, inflammation, Columbia repair. macrophages, stem / progenitor cells. 40,000 80,000 I , ,000 I 40,000 80,000 I 40,000 80,000 I 38,077 80,000 I 40,000 80,000 I Marchant, David McManus, Bruce M. St. Paul's Hospital Matrixmetalloproteinases during coxsackievirus induced myocarditis. Viral myocarditis, MatrixMetalloProteinases, MAP kinases, bosentan, endothelin. 40,000 80,000 I 13,333 13,333 I 40,000 80,000 I 40,000 80,000 I 50, ,000 I, II 40,000 80,000 I Themes I: Basic Biomedical II: Clinical III: Health Services/Systems IV: Population Health 53

60 Heart and Stroke Foundation Research Report Awardee Supervisor(s) Institute Project Keywords Term $ Total $* Theme 40,000 80,000 I ,000 80,000 I 40,000 80,000 I, II Pamenter, Matthew E.M. Haddad, Gabriel Univeristy of California, San Diego Innate immunity and reactive oxygen species contribute to neurogeneration following ischemic stroke. Innate immune system, ischemic stroke, toll-like receptors, reactive oxygen species. Panama, Brian K. Backx, Peter Molecular regulation of Potassium channels, H. Toronto cardiac K+ channels and electrophysiology, heart excitability. disease, arrhythmias, contraction, calcium. Pless, Stephan Ahern, Investigating anti-arrhythmic Arrhythmia, pacemaking, Christopher of British inhibition of voltage-gated stroke, biophysics, A. Columbia sodium channels with pharmacology. unnatural amino acids and fluorescence spectroscopy. Prager- Bourque, McGill Cytoskeletal mechanisms Osmosensory transduction, Khoutorsky, Charles W. regulation of vasopressin, stretchinactivated Masha mechanosensitive cation channels, channels in osmosensory cytoskeleton, hypertension. transduction. Rayner, Katey Moore, Massachusetts Identifying novel Scavenger receptors, Kathryn J. General mechanisms of CD36 atherosclerosis, Hospital activation in atherosclerosis inflammation, Alzheimer's and Alzheimer's disease. disease. Schussler, Olivier Ruel, Marc Cardiac tissue regeneration Cardiac cell transplantation, Ottawa Heart using progenitor/stem myocardial regeneration, Institute cells seeded in a new tissue engineering, biofunctionalized injectable collagen. collagen matrix. Sivagangabalan, Gopal Nanthakumar, Kumaraswamy Toronto General Hospital Identifying the molecular substrate for ventricular fibrillation and developing novel diagnostic and therapeutic interventions. Sudden cardiac death, transcriptomal profiling, cardiac CT, mapping, ablation. Song, Hannah Zandstra, Engineered heart tissue for Stem cell, tissue Peter W. Toronto cardiac cell therapy. engineering, cardiac differentiation. Tremblay, Karine Gaudet, Université de Hypertriglycéridémie sévère Hypertriglycéridémie Daniel Montréal (> 10mmol/L) : Biomarqueurs sévère, risque de risque et de la réponse cardiométabolique, au traitement. pharmacogénétique, études génétiques, études cliniques. Voskas, Daniel Woodgett, Mount Sinai Roles for Gsk-3 in Cardiovascular, signaling, James R. Hospital cardiovascular development. mouse, zebrafish, genetics. 40,000 80,000 I 20,000 60,000 I 12,500 62,500 I, II Singh, Anamika Snutch, Terrance P. of British Columbia Functional effects of omega-3 fatty acids on T-type calcium channel splice variants expressed under normal and cardiopathic conditions. T-type calcium channel, omega-3 fatty acids, cardiovascular disorders, cardiomyocyte electrophysiology, alternative splicing. 35,070 75,070 I 22,917 22,917 I, II 40,000 80,000 I 40, ,000 I, II, IV 40,000 80,000 I * Amount shown represents stipend value only. 54

61 Heart and Stroke Foundation Research Report Wijesekara, Nadeeja T. Hayden, Michael R.; Verchere, Bruce of British Columbia Adiponectin receptor and APPL1 mediated adiponectin signaling and metabolic effects in cardiomyocytes. Cardiomyocytes, adiponectin, APPL1, AdipoR. Wu, Chang-Yi Childs, Sarah Molecular mechanisms Zebrafish, blood vessel, J. Calgary of intersegmental vessel angiogenesis, vascular patterning in zebrafish. malformation, patterning. Yogi, Alvaro Touyz, Rhian Magnesium regulation Aldosterone, magnesium, M. Ottawa Heart of vascular function in TRPM7, signaling pathways, Institute hypertension: role of TRPM7. ROS. Research Scholarships Awardee Supervisor(s) Institute Project Keywords Term $ Total $* Theme Welch, Nicole C. Stys, Peter K. Calgary The role of Schmidt- Lantermann incisure gap junction in axonal calcium homeostasis. Myelin, axons, gap junctions, Ca channels, ischemia. 40, ,000 I 33,333 80,000 I 40,000 80,000 I 40,000 80,000 I Awardee Mentor(s) Institute Project Keywords Term $ Total $* Theme de Denus, Simon White, Michel Institut de Genetic polymorphisms B-type natriuretic peptide, 45,000 90,000 II cardiologie de Montréal related to natriuretic peptides in patients with cardiovascular disease. pharmacogenomics, genomics, biomarker, translational research. Rempel, Gwendolyn R. Clark, Alexander M.; Magill- Evans, Joyce E. Alberta Explicating the influence of parenting on the development of children with CHD. Congenital heart disease, nursing, support, care, behaviour. 45,000 90,000 II,III,IV New Investigators Awardee Institute Project Keywords Term $ Total $* Theme Ahern, Christopher A. of British Columbia Investigating anti-arrhythmic inhibition of voltage-gated sodium channels with unnatural amino acids and fluorescence spectroscopy. Arrhythmia, pacemaking, stroke, biophysics, pharmacology , ,000 I,II Bolz, Steffen- Sebastian Toronto The control of microvascular tone by the Sphingosine-1-phosphate signalling pathway. Microcirculation, arteries, transfection, smooth muscle, sphingosine-1- phosphate signalling , ,000 I Bossé, Yohan Université de Laval Genetic susceptibility to calcific aortic valve stenosis. Aortic stenosis, candidate genes, genomics, microarray, genotyping , ,000 I,II Braam, Geert Branko Alberta AT1 regulation in monocytes of patients with hypertension and chronic kidney disease. Angiotensin II, monocytes, inflammation, hypertension, chronic kidney disease , ,000 I,II Chelikani, Prashen V.G.B. Manitoba G-protein coupled receptors (GPCR's), membrane protein structure, NMR spectroscopy, receptor-drug interactions, molecular modeling. Towards the elucidation of beta2- adrenergic receptor structure , ,000 I Themes I: Basic Biomedical II: Clinical III: Health Services/Systems IV: Population Health 55

62 Heart and Stroke Foundation Research Report Awardee Institute Project Keywords Term $ Total $* Theme Ottawa Health Research Institute Mechanisms to reduce injury and improve recovery from stroke. PPAR gamma, cerebral ischemia, transcription, chromatin, neuron survival. Chen, Hsiao- Huei , ,000 I Claydon, Thomas W. Simon Fraser Structural dynamics of herg potassium channel gating studied using voltage clamp fluorimetry. Electrophysiology, voltage clamp fluorimetry, ion channels, herg, cardiac , ,000 I Claydon, Victoria E. Simon Fraser Cerebrovascular control following spinal cord injury. Blood pressure, cerebral autoregulation, spinal cord injury, autonomic dysreflexia, orthostatic hypotension ,000 I,II Colicos, Michael A. Calgary Role of neuroligin during photoconductive stimulation-driven synaptic reorganization of mammalian neuronal networks. Ischemia, synaptic reorganization, neuronal cultures, neurosilicon interface, neuroligin , ,000 I Devlin, Angela M. of British Columbia Nutrition, epigenetics & risk for cardiovascular disease. Hyperhomocysteinemia, DNA methylation, mice, nutrition, gene expression , ,000 I,II,IV Feng, Zhong-Ping Toronto Modulatory mechanisms underlying membrane targeting of cardiac voltagedependent calcium channels. Calcium channel, surface expression, gene expression, protein kinases, cardiac myocytes , ,000 I Girouard, Héléne Université de Montréal Mechanisms underlying neurovascular coupling dysfuncton in hypertension. Neurovascular coupling, angiotensin, astrocytes, calcium, parenchymal arteries , ,000 I Gramolini, Anthony O. Toronto Molecular basis of PLN regulation and function in cardiac muscle. Calcium, serca, mouse models, phospholamban, cardiac, sarcoplasmic reticulum , ,000 I,II Gros, Robert Robarts Research Institute Regulators of G-protein-coupled receptor-mediated vascular responses. Hypertension, G-protein-coupled receptor kinases, vascular cells, knockdown, adenovirus , ,000 I Hess, David A. Robarts Research Institute Cellular progenitors and molecular mediators of vascular regeneration. Stem cell biology, vascular regeneration, angiogenesis, transplantation, peripheral vascular disease , ,000 I Jassal, Davinder S. St. Boniface G.H. Research Centre The interaction of hyperlipidemia and NOS3 on ventricular remodeling after pressure-induced overload. Chronic pressure overload, nitric oxide, obesity, ventricular remodeling, hyperlipidemia , ,000 I Kassiri, Zamaneh Alberta The MMP-dependent and MMPindependent functions of TIMP-2 in heart disease. Myocardial infarction, pressure overload, remodeling, matrix proteins, MMPs & TIMPs , ,000 I Khan, Zia A. of Western Ontario Vascular stem cells in diabetic complications. Endothelial cells, stem cells, vasculogenesis, angiogenesis, diabetes , ,000 I Kirton, Adam Calgary Modulation of brain plasticity after perinatal stroke. Perinatal stroke, cerebral palsy, neuroplasticity, transcranial magnetic stimulation, clinical trial , ,000 I,II * Amount shown represents stipend value only. 56

63 Heart and Stroke Foundation Research Report Awardee Institute Project Keywords Term $ Total $* Theme Kurata, Harley T. of British Columbia Gating and permeation of inwardlyrectifying potassium channels. KATP channel, inward rectifier potassium channel , ,000 I,II Ledoux, Jonathan Montreal Heart Institute Regulation of CaMKII activity by intracellular calcium pulsars in native endothelium. Endothelium, CaMKII, intracellular Ca2+, electrophysiology, hypertension , ,000 I McMaster Evaluation of a diagnostic strategy for patients with suspected heparin-induced thrombocytopenia (HIT). Heparin-induced thrombocytopenia, clinical prediction rule, thromboembolism. Linkins, Lori- Ann , ,000 II Melacini, Giuseppe McMaster Structural basis for the camp-signal translation in PKA by NMR. Signalling, kinase, camp, allostery, NMR , ,000 I Miller, Gregory E. of British Columbia Depression, inflammation, and risk for coronary heart disease. Depression, behavioral cardiology, inflammation, coronary heart disease, metabolic syndrome , ,000 II,IV Peng, Tianqing Lawson Research Institute PLCgamma/IP3 signaling regulates cardiac TNF-a expression in sepsis. Sepsis, TNF-alpha, cardiomyocyte, phospholipase Cgamma, inositol trisphosphate , ,333 I Proctor, Spencer D. Alberta Atherogenesis, chylomicrons, proteoglycans, insulin-resistance, apolipoproteins. Mechanisms that accumulate apob48- remnant lipoproteins in arterial tissue by proteoglycans during atherogenesis and insulin-resistance , ,000 I Pyle, William Glen Guelph The role of cardiac Z-disc in signal transduction and myocardium. Actin capping protein, intracellular signalling, muscle mechanics, cytoskeleton, heart failure ,000 I Sawicki, Grzegorz (Greg) Saskatchewan Chemical modifications of myosin light chain 1 in oxidative stress and its degradation by MMP-2. Oxidative stress, cardiovascular, ischemia-reperfusion, proteinases, proteomics , ,000 I Seubert, John M. Alberta Role of eicosanoids in the heart: implications of arachidonic acid and its metabolites in regulating myocardial function and ischemic injury. Eicosanoids, cytochrome P450 epoxygenases, ischemia-reperfusion injury, potassium channels, natriuretic peptides , ,000 I Shearer, Jane Calgary Mechanisms of glycogen-induced insulin resistance in diabetic cardiomyopathy. Diabetes, cardiac function, glycogen, metabolism, tracer , ,000 I Thompson, Roger J. Calgary A critical role for pannexin-1 hemichannels in excitotoxic neuronal death. Ischemia, NMDA receptor, necrosis, patch-clamp, imaging , ,000 I Wang, Hao London Health Sciences Centre Soluble CD83 based therapy in cardiac allograft tolerance. Heart transplantation, soluble CD83, tolerance, dendritic cells, T regulatory cells , ,000 I Yan, Andrew T. St. Michael's Hospital Impact of in-centre nocturnal hemodialysis on ventricular remodeling and function in end-stage renal disease. Ventricular remodeling, left ventricular mass, cardiac magnetic resonance imaging, end-stage renal disease, hemodialysis , ,000 I,II Yang, Guangdong Lakehead Regulation of cystathionine gamma-lyase expression in vascular smooth muscle cells. Cystathionine gamma-lyase, hydrogen sulfide, smooth muscle cells, micrornas, cell proliferation , ,000 I Themes I: Basic Biomedical II: Clinical III: Health Services/Systems IV: Population Health 57

64 Heart and Stroke Foundation Research Report Distinguished Clinician Scientist Awardee Institute Project Keywords Term $ Total $ Total $ Total $ Theme HSF (All Partners) HSF* (All Partners)* Coutts, CT and MRI in the triage of Stroke, TIA, 50,000 75, , ,000 II Shelagh B. Calgary TIA and minor cerebrovascular events (CATCH). MRI, recurrent stroke Oudit, Gavin Y. of Alberta Hospital Role of ACE2 in heart disease: using human recombinant ACE2 as potential therapy. Heart failure, renin-angiotensin system, hypertrophy ,000 90, , ,000 I Industry-Supported Research Fellowship Awards The HSF wishes to thank the following industry supporters for their generous contributions to support the HSF Research Program. Awardee Supervisor(s) Institute Project Keywords Term $ HSF Total $ (All Partners) Total $ HSF* Total $ (All Partners)* Theme HSF/AstraZeneca Research Fellowship Kim, Paul Y. Weitz, Jeffrey I. Henderson Research Centre Impact of gamma' - fibrinogen on clot formation at sites of plaque rupture. Haemostasis, thrombosis, fibrinogen, clot abnormality. 0 40, ,000 I HSF/Pfizer Canada Research Fellowship Jarinova, McPherson, Genotype to Cardiovascular 0 40, ,000 I,IV Olga Ruth of Ottawa Heart Institute phenotype: functional analysis of the chromosome 9p21 coronary heart diseaese locus. genetics, GWAS, coronary artery disease, 9p21 risk locus fro CHD, functional analysis. Laplante, Marette, Centre Prévention des Adiponectine, 0 40,000 40,000 80,000 I Marc- André André hospitalier de l'université Laval cardiomyopathies diabétiques par l'adiponectine chez la souris obèse. cardiomyopathie, diabète, tissu adipeux, adipokines. Singh, Krishna K. Verma, Subodh St. Michael's Hospital BRCA1 gene and atherosclerosis. BRCA1, endothelial cells, atherosclerosis. 40,000 40,000 40,000 80,000 I * Amount shown represents stipend value only. 58

65 APPENDIX C GRANTS-IN-AID Photo: Dr. Karmin O ( Manitoba) was the recipient in of a Grant-in-Aid from the Heart and Stroke Foundation of Manitoba titled Role of hepatic inflammatory response in moncyte recruitment and atherogenesis.

66 Heart and Stroke Foundation Research Report British Columbia/Yukon Principal Investigator and Co-Investigator(s) Boyd, Lara A; Eng, Janice J. Brown, Craig E; Delaney, Kerry R. Burtnick, Leslie D. Choy, Jonathan C. Claydon, Thomas W. Claydon, Victoria E; McGrath, Maureen S. Clee, Susanne M. Duronio, Vincent; Steinbrecher, Urs P. Eng, Janice J; Miller, William C.; Brasher, Penelope MA.; Dawson, Andrew S. Fedida, David Fedida, David; Arbour, Laura T. Hoodless, Pamela A.; Underhill, Tully Micheal Institute of Principal Investigator British Columbia Victoria British Columbia Simon Fraser Simon Fraser Simon Fraser British Columbia British Columbia British Columbia British Columbia British Columbia B.C. Cancer Research Centre Project Keywords Term $ Cumulative Theme $ to Promotion of brain reorganization after stroke. Stroke, human, brain, learning, rehabilitation. Peripheral nerve stimulation to Photothrombotic stroke, enhance recovery from cerebral peripheral nerve stimulation, stroke. somatosensation. The structure of gelsolin-capped Actin, gelsolin, cytoskeleton, actin filaments. protein crystallography, protein structure. Regulation of human T cell Heart transplantation, survival by nitric oxide and vasculopathy, nitric oxide, T thioredoxins: role in heart cell, thioredoxin. transplant rejection. Structural dynamics of herg Electrophysiology, voltage potassium channel gating studied clamp fluorimetry, ion using voltage clamp fluorimetry. channels, herg, cardiac. Cerebrovascular control following Blood pressure, cerebral spinal cord injury. autoregulation, spinal cord injury, autonomic dysreflexia, orthostatic hypotension. Identification of a novel obesity Obesity, genetics, positional gene. cloning, risk factor, mouse model. Activation of macrophage growth Apoptosis, macrophages, and survival pathways by oxidized oxidized LDL, scavenger LDL. receptors. Exercise programs in stroke: effect Stroke, rehabilitation, function, of an inpatient supplementary mobility, walking. practice program on lower extremity function. Activation and inactivation Potassium channel, heart, gating of cardiac voltage-gated fluorescence, arrhythmia, potassium channels studied electrophysiology. by electrophysiology and time-resolved fluorescence changes. Further studies of KCNQ1 LONG QT syndrome, long-qt mutations present potassium channel, heart, in a Canadian First Nations arrhythmia, electrophysiology. population. Valve formation in the mouse Embryogenesis, artioventricular canal. atrioventricular canal, valvuogenesis, gene regulation , ,306 I,II 69,919 69,919 I , ,693 I 10,834 24,014 I , ,154 I , ,619 II 113, ,310 I 119, ,971 I 123, ,385 II,III , ,392 I , ,682 I,II,IV 103, ,802 I 60

67 Heart and Stroke Foundation Research Report Principal Investigator Institute of Principal and Co-Investigator(s) Investigator Humphries, Karin H.; Pilote, Louise; British Columbia Norris, Colleen M.; Gao, Min; Singer, Joel Karsan, Aly B.C. Cancer Research Centre Krassioukov, Andrei V.; Ramer, Matt S.; British Columbia Laher, Ismail Linden, Wolfgang British Columbia Project Keywords Term $ Cumulative $ to Theme Sex differences and determinants Sex differences, acute , ,466 II,III of health status post acute myocardial infarction, quality myocardial infarction in younger of life, process of care, adults. psychosocial. Molecular mechanisms of Apoptosis, endothelium, , ,343 I endothelial survival/apoptosis. notch, signal transduction, vascular injury. Vascular function following spinal Autonomic dysreflexia, 76,852 76,852 I cord injury: effects of blood episodic hypertension, pressure instability and exercise. vascular endothelium, exercise, spinal cord injury. Sleep and stress: predictors of Sleep, stress, rumination, 69, ,590 IV failure to recover. blood pressure, recovery. Luo, Honglin St. Paul's Hospital Mechanisms of impaired cardiac Coxsackievirus, viral , ,232 I function in coxsackievirus-induced myocarditis. myocarditis, serum response factor, heart failure, cardiac contractility. McManus, Bruce M.; St. Paul's Hospital Regulation of mesenchymal Vascular injury and repair, 83, ,297 I Knight, Darryl A.; Rahmani, Maziar cell behaviour by versican: implications for arterial remodeling. proteoglycans, versican, alpha-smooth muscle actin, myofibroblast. McManus, Bruce M.; St. Paul's Hospital Signaling networks determine Systems biology, cell 91,098 91,098 I Marchant, David J.; Garmaroudi, Farshid S. pathological events in virusinfected cardiomyocytes. signaling, coxsackievirus, viral myocarditis, heart failure, dilated cardiomyopathy, animal model. McNagny, Kelly M. Role of the CD34 family in vascular CD34, endothelia, smooth 92,400 92,400 I,II,III British Columbia development and function. muscle, transgenic mice, development. Murphy, Timothy H. Optimizing hypothermic and Stroke, in vivo, imaging, 101, ,526 I British Columbia redox-mediated neuroprotection to recover fine synaptic structure and sensorimotor function in vivo following ischemia and reperfusion. dendrite, calcium. Naus, Christian C.G. The role of gap junctions in Stroke, gap junctions, 98,660 98,660 I British Columbia neuroprotection in stroke. connexxin, neuroprotection, transgenics. Pang, Catherine C.Y. British Columbia Cardiovascular role of inos in diabetes. Blood pressure, diet, metabolic syndrome, risk factors, vascular dysfunction , ,978 I Themes I: Basic Biomedical II: Clinical III: Health Services/Systems IV: Population Health 61

68 Heart and Stroke Foundation Research Report Principal Investigator and Co-Investigator(s) Pilote, Louise; Karp, Igor: Bacon, Simon L.; Chalifour, Lorraine E.; Cox, Jafna L.; Dasgupta, Kaberi; Daskalopoulou, Styliani-Stella ; Eisenberg, Mark J.; Engert, James C.; Ghali, William A.; Hamet, Pavel; Humphries, Karin H.; Khan, Nadia A.; Lavoie, Kim L.; Norris, Colleen M.; Rabi, Doreen M.; Stark, Ken D.; Tagalakis, Vicky; Tremblay, André; Tu, Jack V. Pryzdial, Edward L.G. Rossi, Fabio M.V. Tibbits, Glen F.; Paetzel, Mark W. van Eeden, Stephan F. Van Petegem, Filip Walley, Keith R.; Murkin, John M. Wang, Yu Tian Institute of Principal Investigator McGill British Columbia British Columbia Simon Fraser St. Paul's Hospital British Columbia British Columbia British Columbia Project Keywords Term $ Cumulative Theme $ to Genesis praxy: Gender and sex determinants of cardiovascular disease from bench to beyond in premature acute coronary syndrome. Cardiovascular disease, gender and sex differences, premature acute coronary syndrome, risk factors, determinants of health. Coagulation initiated on herpes Coagulation, fibrinolysis, viruses. biochemistry, herpes simplex, cytomegalovrus, annexin. Isolation, characterization, Fat tissue, stem cells, and therapeutic potential of purification, obesity, adipogenic progenitors. metabolism. Modulation of cardiac Cardiac troponin C, familial myofilament sensitivity to calcium: hypertrophic cardiomyopathy, role in familial hypertrophic Ca homeostasis. cardiomyopathy. The impact of statins on air Statins, air pollution, pollution induced progression of atherosclerosis. atherosclerosis. Cardiac ryanodine receptors: Calcium, ryanodine receptors, crystallographic analysis of ion channel, crystallography, disease mutants and regulation by protein structure. calmodulin. Genetic determinants of Cardiopulmonary bypass, neurocognitive dysfunction genes, polymorphism, following cardiopulmonary cognitive dysfunction. bypass. Investigation into the molecular NMDA receptor, exitotoxicity, mechanisms mediating stroke, AMPA receptor, exitotoxicity - developing novel apoptosis. post-stroke therapies , ,241 II,III,IV 107, ,165 I 100, ,920 I 132, ,987 I 74, ,698 I,III 111, ,810 I , ,000 I,II , ,101 I 62

69 Heart and Stroke Foundation Research Report Principal Investigator and Co-Investigator(s) Wellington, Cheryl L.; Pritchard, Haydn; Hirsch Reinshagen, Veronica U. Zehr, E. Paul Institute of Principal Investigator British Columbia Victoria Alberta/Northwest Territories/Nunavut Principal Investigator and Co-Investigator(s) Anderson, Todd J.; Friedrich, Matthias G.; Strohm, Oliver; Wyse, D. George Bains, Jaideep S. Beaulieu, Christian; Butcher, Ken S.; Emery, Derek J.; Berthiaume, Luc G. Braam, Geert Branko; Jindal, Kailash K; Mueller, Thomas F.; Ballermann, Barbara J.; Boden, Lisa; Zuberbuhler, Lyn Brindley, David N. Institute of Principal Investigator Calgary Calgary Alberta Alberta Alberta Alberta Project Keywords Term $ Cumulative Theme $ to Ischemic postconditioning in ST elevation myocardial infarction. Percutaneous coronary intervention, myocardial infarction, ischemia, postconditioning, endothelial function. Presynaptic release dynamics at Vasopressin, hypothalamus, glutamate synapses: Implications electrophysiology, synaptic, for controlling the activity of glutamate. vasopressin neurons. Advanced MRI methods for brain Magnetic resonance imaging, evaluation in acute stroke. acute stroke, sodium MRI, patients, brain. Role of mitochondrial protein Protein fatty acylation, fatty acylation in the metabolic obesity, type II diabetes, syndrome. metabolism, mitochondria. AT1 regulation in monocytes of Angiotensin II, monocytes, patients with hypertension and inflammation, hypertension, chronic kidney disease. chronic lung disease. Control of cell signaling and Dyslipidemia, fatty liver, fuel hepatic metabolism by lipins. partitioning, hormonal action, phospholipid synthesis, triaglycerol synthesis. Project Keywords Term $ Cumulative $ to Theme Role of lecithin: cholesterol LCAT, brain, lipoprotein, , ,148 I acyltransferase (LCAT) in brain traumatic brain injury, lipoprotein metabolism. apolipoprotein E. Exploiting neuromechanical Stroke, reflex, feedback, 102, ,996 I,II effects of arm and leg coupling to walking, central patterning, improve recovery of walking after cutaneous. stroke. 90, ,000 II , ,000 I 57, ,500 I,II , ,000 I 52,000 95,333 I,II 57, ,500 I Themes I: Basic Biomedical II: Clinical III: Health Services/Systems IV: Population Health 63

70 Heart and Stroke Foundation Research Report Principal Investigator and Co-Investigator(s) Cameron, Jill I.; Naglie, Gary; Gignac, Monique A.M.; Hoch, Jeffrey S.; Cheung, Angela M.; Huijbregts, Maria PJ.; Silver, Frank L.; Bayley, Mark T.; Finestone, Hillel M.; Warner, Grace; Phillips, Stephen J.; Green, Theresa L.; Weir, Nic; Suddes, Michael J. Casey, Joseph R. Chelikani, Prasanth VRK Chen, S.R. Wayne Childs, Sarah J. Clanachan, Alexander S.; Finegan, Barry A. Colbourne, Frederick Davidge, Sandra T. Duff, Henry J.; Muruve, Daniel A.; Beck, Paul L. Dukelow, Sean P.; Hill, Michael D.; Scott, Stephen H. Institute of Principal Investigator Toronto Alberta Calgary Calgary Calgary Alberta Alberta Alberta Calgary Foothills Medical Centre Project Keywords Term $ Cumulative Theme $ to Optimizing stroke family caregiver Stroke, family care-giving, support across the care continuum support, intervention, by improving the timing of randomized controlled trial. intervention delivery Chloride/bicarbonate exchangers Bicarbonate transport, in cardiac hypertrophy. hypertrophy, ischemia, ph regulation. Barriatric surgery for obesity: Gastric bypass surgery, Effects on energy balance and obesity, gastrointestinal cardiovascular function. hormones, energy balance, cardiovascular function. Molecular mechanism of oxidative Cardiac arrhythmia, oxidative modulation of the cardiac stress, EC coupling, ryanodine receptor. sarcoplasmic reticulum, Ca2+ release, ryanodine receptor, FRET, single channel recording. Signalling pathways in vascular Angiogenesis, development, integrity. genetics, zebrafish, hemorrhage. Enhancing post-ischemic recovery Ischemia-reperfusion, of stressed hearts. contractility, glucose metabolism, oxidative stress, stress kinase signalling. Rodent studies of recovery after Stroke, intracerebral intracerebral hemorrhage. hemmorhage, rehabilitation, neuroplasticity, rodent. Neuronal nitric oxide synthase Endothelial, vascular, nitric (nnos) as a regulator of estrogen oxide, estrogen, diabetes. effects on the vasculature in health and diabetes. Calcineurin induced heart failure Inflammasone, calcineurin, and the inflammasome. interlukin-1 beta, heart failure, sudden death, protein kinase C. Rehabilitation, Stroke deficits and Stroke, rehabilitation, Robotic Technology (RESTART). sensation, proprioception, robotics. 16,000 38,500 II,III,IV , ,000 I,II 57,000 57,000 I 57,000 57,000 I , ,000 I , ,000 I 57,000 57,000 I 57,000 57,000 I 57,000 57,000 I 90,000 90,000 II 64

71 Heart and Stroke Foundation Research Report Principal Investigator and Co-Investigator(s) Dyck, Jason R.B. Exner, Derek V. Fedak, Paul W.M. Frayne, Richard; Mahallati, Houman Giles, Wayne R. Hollenberg, Morley D. Jurasz, Paul K. Kargacin, Gary J.; Kargacin, Margaret E. King, Kathryn M.; Quan, Hude; Mather, Charles M.; Khan, Nadia A. Kirton, Adam; Chen, Robert; deveber, Gabrielle A.; Hill, Michael D.; Demchuk, Andrew M.; Barlow, Karen M. Kubes, Paul Institute of Principal Investigator Alberta Calgary Calgary Calgary Calgary Calgary Alberta Calgary Calgary Calgary Calgary Project Keywords Term $ Cumulative Theme $ to The role of adipose triglyceride lipase in the pathogenesis of lipotoxic cardiomyopathy. Lipotoxic cardiomyopathy, cardiac metabolism, adipose triglyceride lipase, lipid accumulation, AMPK. Torsion optimization to reduce Heart failure, symptoms and improve outcomes resynchronization, in non-responders (TORSION). remodelling, echocardiography, torsion. Role of the metalloendopeptidase Metalloendopeptidases, cell pathway in heart failure. transplantation, paracrine effect, remodelling, heart function. Non-contrast enhanced magnetic Magnetic resonance resonance angiography. angiography (MRA), renal and peripheral arterial disease (RAD, PAD), vascular imaging, atherosclerosis. Biophysical analyses of Adenosine triphosphate electrophysiological effects of (ATP), purenergic receptors, ATP on cardiac fibroblasts and ion channels, fibroblast, myocytes. myocytes. Tyrosine kinases, proteinases, their Tyrosine, kinase, proteinases, receptors, vascular diversity and receptor, vascular diversity, vascular function. vascular function. Regulation of angiogenesis by Platelets, angiogenesis, platelet-derived angiostatin. angiostatin, endothelial cells, apoptosis. Ion channels of the sarcoplasmic Sarcoplasmic reticulum, reticulum. compensatory charge movement, potassium channels, chloride channels. Understanding ethnic and gender Ethnicity, gender, acute based differences in presenting coronary syndrome, with acute coronary syndrome presentation, qualitative. and in accessing cardiac care: a qualitative investigation. Modulation of brain plasticity after Perinatal stroke, cerebral perinatal stroke. palsy, neuroplasticity, transcranial magnetic stimulation, clinical trial. Neutrophil transmigration: a novel Inflammation, role for endothelial LSP1 and microvasculature, domes. cardiovascular physiology, endothelium, neutrophil. 52,000 95,333 I , ,000 II , ,000 I , ,000 I,II 57,000 57,000 I,II 57, ,500 I 49,000 89,833 I 57, ,500 I 57,000 57,000 II,III,IV 90, ,000 I,II 57, ,500 I Themes I: Basic Biomedical II: Clinical III: Health Services/Systems IV: Population Health 65

72 Heart and Stroke Foundation Research Report Principal Investigator and Co-Investigator(s) Lehner, Richard Lopaschuk, Gary D. Lytton, Jonathan McAlister, Finlay A.; Majumdar, Sumit R.; Shuaib, Ashfaq; Thompson, Ann E.; Padwal, Raj S.; Tsuyuki, Ross T.; Dean, Naeem; Grover, Steven A. McMurtry, Michael Sean Oudit, Gavin Y. Plane, Frances Seubert, John M. Shimoni, Yakhin; Nygren, Anders Stickland, Michael K.; Ezekowitz, Justin A.; Jones, Kelvin E.; Haykowsky, Mark J.; Paterson, David Ian Sykes, Brian D. Tse, Amy M. Institute of Principal Investigator Alberta Alberta Calgary Alberta Alberta Alberta Alberta Alberta Calgary Alberta Alberta Alberta Project Keywords Term $ Cumulative Theme $ to Triacylglycerol metabolism and atherosclerosis. Triacylglycerol, cholesterol, lipoproteins, lipase, atherosclerosis, adenovirus. The metabolic basis of heart Obesity, energy metabolism, failure in obesity. fatty acids, lipotoxicity. Molecular analysis of NCX1 Na/Ca exchanger, calcium regulation. signaling, structure-function, molecular biology, heart disease. Preventing recurrent vascular Stroke, prevention, events and neurological worsening hypertension, hyperlipidemia. through intensive organized casemanagement (PREVENTION) trial. Vascular metabolism and Endothelium, metabolism, angiogenesis. arteriogenesis, angiogenesis, peripheral arterial disease. Role of PI3K in pathological Signaling, hypertrophy, biomechanical stress and heart cardiovascular physiology, failure. heart failure, extracellular matrix. Endothelial-smooth muscle cell Enothelial dysfunction, nitric communication: Key role of KCa. oxide, potassium channel, vasodilation, smooth muscle. Beneficial fatty acids in the Cardioprotection (ischemia/ heart: epoxyeicosatrienoic acid reperfusion), PI3K, cardioprotective signaling axis. eicosanoids, ATP-sensitive K+ channels, mitochondria, BNP. Regulation of cardiac impulses Diabetes, impulse propagation in the diabetic heart. propagation, arrhythmia, gap junction, gender. Carotid chemoreception and Sympathetic nervous activity, exercise in health and chronic chemoreception, exercise, heart failure. heart failure, blood flow. Structure of cardiac troponin in Structure, troponin C, complex with cardiotonic drugs. troponin I, calcium binding, cardiotonic drugs, NMR. Regulation of chemotransduction Calcium, exocytosis, in carotid bodies. transmitter release, respiration, oxygen sensing. 57,000 57,000 I 57, ,500 I , ,000 I 57, ,500 II,III 52,000 95,333 I , ,000 I , ,000 I 57,000 57,000 I , ,000 I,II 57, ,500 I,II , ,000 I 57, ,500 I 66

73 Heart and Stroke Foundation Research Report Principal Investigator and Co-Investigator(s) Tuor, Ursula I.; Kirton, Adam Winship, Ian R. Yager, Jerome Y. Yong, V. Wee; Xue, Mengzhou Young, Howard S. Zamponi, Gerald W. Zaugg, Michael Zhang, Dawei Institute of Principal Investigator Calgary Alberta Alberta Calgary Alberta Calgary Alberta Alberta Project Keywords Term $ Cumulative Theme $ to 57, ,500 I 57,000 57,000 I , ,000 I 57,000 57,000 I Diagnosis of axonal degeneration following cerebral hypoxicischemic injury in neonates. Magnetic resonance imaging, axonal degeneration, cerebral hypoxia-ischemia, immunohistochemistry. Neuroplasticity beyond peri-infarct Neuroplasticity, axonal cortex: a role of adaptive changes sprouting, spinal cord, in the spinal cord in stroke functional recovery, in vivo recovery. imaging. Averting perinatal brain damage Neonatal, hypoxiaischemia, using a natural health product: a white-matter novel approach to the prevention injury, neuroprotection, of white matter injury in premature complementary medicine and infants. natural health products. Understanding and manipulating Intracerebral hemmorhage, microglia/macrophage microglia/macrophages, activity following intracerebral matrix metalloproteinases, hemmorhage to confer protease-activated receptors, neuroprotection. neuronal death. Molecular insights into heart Heart disease, calcium disease - Structure, function and transport, phosphorylation, regulation of SERCA2a. structure-function, genetic defects. Trafficking of L-type calcium Calcium channel, L-type, channels. targeting, patch clamp, auxiliary subunits. Myocardial protection by Preconditioning, myocardial anesthetic preconditioning: infarction, remodeling, infarct-size limitation and signaling, anesthetics. signaling pathways in post-infarct remodeled hearts. Molecular mechanism of PCSK9- Low density lipoprotein promoted degradation of the receptor, PCSK9, receptor LDLR. recycling, cell culture, protein purification. 57, ,500 I , ,000 I 52,000 95,333 I 57,000 57,000 I Themes I: Basic Biomedical II: Clinical III: Health Services/Systems IV: Population Health 67

74 Heart and Stroke Foundation Research Report Saskatchewan Principal Investigator and Co-Investigator(s) Cayabyab, Francisco S. Desai, Kaushik; Wu, Lingyun (Lily) Fisher, Thomas E. Haas, Thomas A. Hiebert, Linda M. Meng, Qing H.; Adeli, Khosrow Ndisang, Joseph Fomusi Stone, Scot J. Walz, Wolfgang Wu, Lingyun (Lily) Institute of Principal Investigator Saskatchewan Saskatchewan Saskatchewan Saskatchewan Saskatchewan Hospital for Sick Children Saskatchewan Saskatchewan Saskatchewan Saskatchewan Project Keywords Term $ Cumulative $ to Theme Adenosine A1 receptor and Adenosine and glutamate , ,000 I AMPA receptor interactions receptor interactions, synaptic at a postsynaptic locus: role depression, neurotoxicity, in hippocampal neurotoxicity brain slice electrophysiology, during ischemia. interfering peptide strategies. Is methylglyoxal the mediator Insulin resistance, methylglyoxal, 45,000 45,000 I of high glucose-induced insulin type 2 diabetes, endothelial resistance and endothelial dysfunction, oxidative stress. dysfunction? Implications for type 2 diabetes. An osmosensitive K+ current Vasopressin, K+ current, , ,000 I that regulates vasopressin supraoptic nucleus, osmosensitivity, release. patch clamp. Allosteric regulation of GP IIb/ Platelets, GP IIb/IIIa, integrins, 45,000 90,000 I,II IIIa. aggregation, inhibitors. Oral heparins. Heparins, oral thrombosis, , ,000 I absortion, endothelium. Methylglyoxal (MG), a key Methylglyoxal (MG), , ,000 I mediator of diet-induced insulin inflammation, oxidative stress, resistance, dyslipidemia, and insulin resistance, atherosclerosis. atherosclerosis. Upregulating the heme Diabetes, fibross, apoptosis, 40,000 40,000 I,II,III,IV oxygenase system protects Heme oxygenase inducers, pancreatic tissue. oxydative stress. Diacylglycerol acyltransferase Obesity, triacylglycerol, diacylglycerol 45,000 45,000 I (DGAT) enzymes and triacylglycerol acyltransferase, topology, synthesis. regulation. Inflammation in experimental Inflammation, lacunar infarction, , ,000 I lacunar infarction. astrocytes, microglia, neuronal degeneration. Mitochondrial methylglyoxal Methylglyoxal, superoxide, 65, ,000 I and mitochondrial function in complex III, mitochondria, vascular smooth muscle cells. vascular smooth muscle cells. 68

75 Heart and Stroke Foundation Research Report Manitoba Principal Investigator and Co-Investigator(s) Anderson, Christopher M. Anderson, Hope D.I. Bhullar, Rajinder P. Dakshinamurti, Shyamala Del Bigio, Marc R. Duhamel, Todd A. Hatch, Grant M. Kardami, Elissavet Kirshenbaum, Lorrie A. McNicol, Archibald Mesaeli, Nasrin Institute of Principal Investigator Manitoba St. Boniface G.H. Research Centre Manitoba Manitoba Manitoba St. Boniface G.H. Research Centre Manitoba St. Boniface G.H. Research Centre St. Boniface G.H. Research Centre Manitoba St. Boniface G.H. Research Centre O, Karmin Manitoba Parkinson, Fiona E.; Albensi, Benedict C.; Martin, Melanie Stetefeld, Joerg Manitoba Manitoba Project Keywords Term $ Cumulative $ to Theme Poly (ADP-ribose) polymerase Bnip3, PARP, cerebral ischemia, 50,000 50,000 I (PARP)-induced Bnip3 signaling in apoptosis, mitochondrial cerebral ischemia. dysfunction. Regulation of cardiac hypertrophy by the CB2 cannabinoid receptor. Calmodulin interaction with Rac1-Cdc42 and platelet function. Thromboxane receptor regulation in hypoxic pulmonary hypertension of the newborn. Periventricular hemorrhage in immature brain. The role of physical activity to enhance myocardial calciumtransport for the prevention of diabetic cardiomyopathy. Regulation of cardiolipin biosynthesis in the heart. Connexin-43 and cardiac myocyte proliferation. Mechanisms of P53 mediated apoptosis in ventricular myocytes. Oral pathogens, MAP kinases and platelets. Regulation of cell proliferation by calreticulin. Role of hepatic inflammatory response in moncyte recruitment and atherogenesis. Stroke injury in genetic mouse models. Structure-based approach to decipher high efficient integrin a2b1 interactions at molecular level and their biomedical application. Endocannabinoid, cannabinoid receptors, anandamidek cardiac myocyte, hypertrophy. Rac1, Cdc42, GTPases, calmodulin, platelet, CHRF cells. Thromboxane receptor, pulmonary hypertension, milrinone, phosphorylation, palmitoylation. Brain hemorrhage, premature birth, cerebral palsy, animal models, imaging. Physical activity, diabetic cardiomyopathy, calcium regulation, diastolic function Cardiolipin, heart failure, lipid, metabolism. Connexin-43, DNA synthesis, signal transduction, TGF-beta, heart cells. P53, apoptosis, heart failure, ventricular myocytes, cell culture. Platelets, periopathogens, signaling, inflammation, secretion. Calreticulin, cell proliferation, cell biology, signal transduction, growth factors. Inflammatory response, chemokines, oxidative stress, atherosclerosis, liver. Ecto 5'-neucleotidase, equilibrative nucleoside transporter 1, magnetic resonance imaging, electrophysiology, adenosine. Rhodocetin-integrin, snake lectin, x-ray crystallography, integrated approach, FRETtechnology. 50,000 50,000 I 50,000 50,000 I 50,000 50,000 I 43,750 87,500 I,II 50,000 50,000 I 50,000 50,000 I 48, ,000 I 50,000 50,000 I 45, ,000 I 43,750 87,500 I 50,000 50,000 I 50,000 50,000 I 50,000 50,000 I,II Themes I: Basic Biomedical II: Clinical III: Health Services/Systems IV: Population Health 69

76 Heart and Stroke Foundation Research Report Ontario Anand, Sonia S.; Engert, James C.; Gaudet, Daniel; Gerstein, Hertzel C.; Pare, Guillaume; Beyene, Joseph; Xie, Changchun McMaster Genome wide association study of metabolic syndrome traits among south asians. Genomics, genetics, ethnicity, metabolic syndrome. Anand, Sonia S.; McMaster South asian heart and health Ethnicity, prevention, Shah, Baiju R.; risk assessment project. cardiovascular, culture, Middleton, internet, knowledge Catherine A.; translation. Punthakee, Zubin; Mente, Andrew; Islam, Shofiqul M.; Samaan, Zainab; Lear, Scott A. Andrew, R. David; Queen's Mechanisms that drive RT-PCR, anoxic Jin, Albert Y.; neuronal swelling and depolarization, water pump, Ferguson, Alastair dysfunction in stroke. swelling, imaging. V. Attisano, Liliana The role of Foxh1 in heart Early development, Toronto development. congenital heart disease, Foxh1, transcription, TGFbeta. Atzema, Clare L.; Institute for Atrial Fibrillation in The Atrial fibrillation, emergency Dorian, Paul; Clinical Evaluative Emergency Room: the AFTER department, health services, Tu, Jack V.; Sciences study. clinical prediction rule, Austin, Peter C. arrhythmia. Austin, Richard C. McMaster Contributions of the unfolded Adipogenesis, obesity, protein response pathway to cardiovascular disease, adipogenesis and obesity. endoplasmic reticulum stress, metabolic syndrome. Principal Investigator Institute of Principal Project Keywords Term $ Cumulative Theme and Co-Investigator(s) Investigator $ to Adams, Michael A. Queen's Antihypertensive treatment Sexual dysfuntion, aging, , ,498 I strategies in the management of sexual dysfunction. vascular structure and function, pharmacotherapy, hypertension, endothelial function. Adeli, Khosrow Hospital for Sick Molecular mechanisms of Apolipoprotein B, 135, ,598 I Children apolipoprotein B degradation. degradation, proteasome, ER60, autophagy Adeli, Khosrow Hospital for Sick Children Molecular mechanisms of hepatic VLDL overproduction in insulin resistance. Dyslipidemia, insulin resistence, VLDL, apolipoprotein B, hamster , ,764 I 90,000 90,000 I,IV 70,000 70,000 III,IV 84, ,762 I,II 68,920 68,920 I 70,000 70,000 II,III,IV , ,702 I 70

77 Heart and Stroke Foundation Research Report Institute of Principal Investigator Health Network London Health Sciences Centre Health Network Ottawa Toronto Toronto Ottawa Hospital Research Institute Toronto Toronto Guelph Project Keywords Term $ Cumulative Theme $ to Transcriptional regulation of cardiac transient outward K+ currents and function in heart. Heart disease, gene transcription, electrophysiology, arrhythmias, hypertrophy. Coffee - cardiovascular drug Drug interactions, coffee, interactions. pharmacokinetics, pharmacodynamics, dihydropyridine, calcium channel antagonists. The ENIGMA-II trial. Nitrous Myocardial infarction, cardiac oxide anaesthesia and cardiac death, randomized trial, morbidity after major surgery: a nitrous oxide. randomized controlled trial Trafficking of NMDA receptors Stroke, NMDA, during stroke. electrophysiology, 2-photon uncaging, 2-photon imaging. Discoidin domain receptors in Atherosclerosis, inflammation, atherosclerosis. extracellular matrix, vascular biology, mouse models. Cadherins and regulation of Cadherin, polarity, migration, smooth muscle cell function. vasular smooth muscle, restenosis. Glycine and brain ischemia. Synaptic transmission, glutamate, GABA, patch-clamp recordings, stroke. A novel cardiovascular Resistance arteries, role for the cystic fibrosis sphingosine-1-phosphate, transmembrane conductance vascular smooth muscle, regulator (CFTR): a critical cystic fibrosis transmembrane transporter in the sphingosine- conductance regulator 1-phosphate degradation (CFTR), transfection. pathway. Mechanisms that regulate the Resistance arteries, pressure-dependant activation sphingosine kinase 1, of sphingosine kinase 1 in vascular smooth muscle, resistance artery smooth unconventional myosins, muscle cells. transfection. Regulation of fatty acid Fatty acid transporters, transport in the heart. transport, metabolism, heart, cardiac myocytes , ,164 I,II 55,879 55,879 I,II 80, ,000 II Principal Investigator and Co-Investigator(s) Backx, Peter H. Bailey, David G.; Dresser, George K.; Arnold, J. Malcolm O. Beattie, William S.; Devereaux, Philip J.; Choi, Peter T-L.; Jacka, Michael J.; Badner, Neal H.; Yang, Homer Y.H.; Schricker, Thomas P.S.; Buckley, David Norman N. Béïque, Jean- Claude Bendeck, Michelle P. Bendeck, Michelle P. Bergeron, Richard Bolz, Steffen- Sebastian Bolz, Steffen- Sebastian Bonen, Arend 58,119 58,119 I 140, ,820 I , ,476 I 57,720 57,720 I 74,523 74,523 I 80, ,832 I , ,296 I Themes I: Basic Biomedical II: Clinical III: Health Services/Systems IV: Population Health 71

78 Heart and Stroke Foundation Research Report Principal Investigator and Co-Investigator(s) Brooks, Dina; McIlroy, William E.; Black, Sandra E.; Gladstone, David J.; Oh, Paul I.T.; Ween, Jon Erik Cameron, Jill I.; Naglie, Gary; Gignac, Monique A.M.; Hoch, Jeffrey S.; Cheung, Angela M.; Huijbregts, Maria P.J.; Silver, Frank L.; Bayley, Mark T.; Finestone, Hillel M.; Warner, Grace; Phillips, Stephen J.; Green, Theresa L.; Weir, Nic; Suddes, Michael J. Carrier, Marc; Rodger, Marc A.; Tao, Hardy H.; Ramsay, Timothy O.; Coyle, Douglas A.; Wells, Philip S.; Le Gal, Grégoire.; Lee, Agnes Y. Y.; Lazo- Langner, Alejandro; Tagalakis, Vicky Cattral, Mark S. Cepinskas, Gediminas Chan, Anthony K.C. Chan, Anthony K.C. Chan, Christopher T.; Leong-Poi, Howard M.; Yuen, Darren A. Institute of Principal Investigator Toronto Toronto Ottawa Health Research Institute Toronto General Hospital Lawson Health Research Institute McMaster McMaster Toronto General Hospital Project Keywords Term $ Cumulative $ to Theme Effect of cardiac rehabilitation Stroke, transient ischemic 80, ,000 II for individuals after transient attack, exercise, cardiac ischemic attack. rehabilitation, aerobic capacity. Optimizing stroke family Stroke, family care-giving, 104, ,743 II, III, caregiver support across the support, intervention, IV care continuum by improving randomized controlled trial. the timing of intervention delivery Screening for previously Venous thromboembolism, 80, ,000 II, III undiagnosed malignancy in randomized controlled patients with unprovoked trial, cancer, screening, venous thromboembolism: comprehensive computed a randomized controlled tomography. trial using a comprehensive computed tomography of the abdomen/pelvis. Role of immediate dendritic Transplantation tolerance, , ,082 I cell precursors in allograft dendritic cells, ontogeny, rejection and tolerance. rejection, migration. Paracellular and intracellular Inflammation / sepsis, 81,029 81,029 I mechanisms of cerebrovascular microvascular endothelium, endothelial cell dysfunction in astrocytes, cell signaling, sepsis. leukocytes. Carbohydrate variation effects Children, thromboemolism, , ,680 I in the protein C pathway (anti) coagulation, protein C, during development. glycosylation. Surface mechanisms of Antithrombin, heparin, , ,869 I anticoagulant ATH complex. anticoagulant, endothelium, thrombosis. Towards an improved Renal failure, endothelial 65, ,949 I,II understanding of vascular function, vascular progenitor progenitor cell biology in cells, nocturnal hemodialysis. uremia. 72

79 Heart and Stroke Foundation Research Report Principal Investigator Institute of Principal and Co-Investigator(s) Investigator Chauhan, Vijay S.; Toronto General Backx, Peter H.; Hospital Wright, Graham A.; Woo, Minna Chen, Hsiao-Huei Ottawa Health Research Institute Cherney, David Z.I.; Toronto General Reich, Heather N. Hospital Chidiac, Peter; Feng, Qingping Western Ontario Ciriello, John Western Ontario Connelly, Philip W.; St. Michael's Ng, Dominic S. Hospital Cook, Deborah J.; McMaster McIntyre, Lauralyn A.; Marshall, John C.; Meade, Maureen O.; Lamontagne, François; Crowther, Mark A.; Dodek, Peter M.; Muscedere, John G.; Hall, Richard I. Copeland, John W. Ottawa Project Keywords Term $ Cumulative Theme $ to Structural and functional determinants of T wave alternans in human Repolarization, ventricular arrhythmias, cardiomyopathy, human, electrocardiography. cardiomyopathy. Mechanisms to reduce injury Transcription, stroke, and improve recovery from chromatin, CREB, PPAR stroke. gamma, cerabral ischemia, neuron survival. Hemodynamic and molecular Diabetes mellitus, mechanisms of hyperfiltration hyperfiltration, direct renin in type 1 diabetes mellitus. inhibition, endothelial function, urine proteomics. Mechanism of the protective RGS2, cardiac hypertrophy, effect of RGS2 in cardiac aortic banding, mrna hypertrophy. translation, GPCR signaling. Leptin links obstructive Obesity, hypertension, sleep apnea, obesity and obstructive sleep apnea, hypertension. leptin, brainstem, chemoreceptor reflex, baroreceptor reflex. Studies of the lactonase Paraoxonase, lactones, activity of paraoxonase 1 - an cardiovascular disease, HDL. HDL associated enzyme of relevance to cardiovascular disease. PE-METRICS: pulmonary Pulmonary embolism, critical embolism: methodology, care, intensive care unit, epidemiology & treatment In venous thromboembolism. critical care study. Role of formin proteins in shear Actin cytoskeleton, shear stress-induced cytoskeletal stress, atherosclerosis, formin, remodeling in endothelial cells. microtubules. 108, ,501 I,II , ,883 I 78,795 78,795 I,II 75,970 75,970 I , ,661 I , ,000 I,II 49,903 49,903 II , ,768 I Cote, Graham P. Queen's Formation and function of Smooth muscle, signal , ,982 I invadopodia in vascular smooth muscle cells. transduction, cell motility, actin cytoskelton, myosin. Cregan, Sean P. Western Ontario Mechanisms of P53 induced neuronal apoptosis. Stroke, p53, apoptosis, oxidative damage, neuronal injury , ,117 I Themes I: Basic Biomedical II: Clinical III: Health Services/Systems IV: Population Health 73

80 Heart and Stroke Foundation Research Report Principal Investigator and Co-Investigator(s) Crowther, Mark A.; Cook, Deborah J.; Warkentin, Theodore E. Crowther, Mark A.; Kovacs, Michael J.; Schulman, Sam Cunningham, Charles H.; Connelly, Kim A.; Dick, Alexander J. Cybulsky, Myron I. Danckert, James A.; Roy, Eric A. Daneman, Denis; Curtis, Jacqueline Dawson, John F. de Bold, Adolfo J. de Bold, Adolfo J.; Kuroski de Bold, Mercedes L. Demers, Catherine; Harkness, Karen Irene; Heckman, George A.W.; McKelvie, Robert S.; Patterson, Christopher J.; Prior, Peter L.; Teo, Koon K.; Pizzacalla, Anne Marie Institute of Principal Investigator McMaster McMaster Sunnybrook Health Sciences Centre Health Network Waterloo Hospital for Sick Children Guelph Ottawa Heart Institute Ottawa Heart Institute McMaster Project Keywords Term $ Cumulative Theme $ to HITEC (Heparin induced thrombocytopenia evaluation in critical care) - Renewal. Adjudication, evaluation, thrombosis, heparin, methodology. Does low dose oral vitamin K Randomized trial, warfarin, improve the quality of warfarin vitamin K, thromboembolism, anticoagulation? multicentre. Metabolic Imaging with MRI for Metabolism, heart failure, myocardial salvage. hyperpolarized, MRI, imaging. Endothelial cell NF-kappaB Endothelial cells, NF-kappaB, homeostasis and function in homeostasis, atherosclerosis, atherosclerosis. transgenic mice. Rehabilitating unilateral Neglect, rehabilitation, neglect: contrasting prism prisms adaptation, saccade adaptation with saccade adaptation. adaptation. Adolescent type 1 diabetes Diabetes, microalbuminuria, cardio-renal intervention trial nephropathy, cardiovascular (AdDIT). disease, clinical trial. Expression and characterization Cardiac actin mutations, of human cardiac actin mutants hypertrophic and dilated linked to hypertrophic and cardiomyopathy, baculovirus dilated cardiomyopathies. protein expressions, actin reconstitution assays, ectopic expression. Regulation of the endocrine Natriuretic peptides, gene function of the heart. knockdown, mirna and mrna transcriptomes, cardiac hypertrophy. Studies on cardiac structure Natriuretic peptides, acute and function post myocardial myocardial infarction, therapy, infarction following fusion proteins. administration of a long acting ANF analogue. The impact of mild cognitive Heart failure, self-care, mild deficits at hospital discharge cognitive deficits. on self-care in older heart failure patients. 58,430 58,430 II,III 0 86,575 I,II 81,618 81,618 I 124, ,412 I 48,760 48,760 I,II 91, ,225 II , ,898 I 60,360 60,360 I 64,960 64,960 I,II 98, ,661 II,III 74

81 Heart and Stroke Foundation Research Report Institute of Principal Investigator Sunnybrook Health Sciences Centre St. Michael's Hospital Robarts Research Institute Mount Sinai Hospital Sunnybrook Health Sciences Centre Sunnybrook Health Sciences Centre Ottawa Hamilton Health Sciences Corporation Project Keywords Term $ Cumulative Theme $ to Endothelial progenitor cell C ell therapy, magnetic modification to improve left resonance imaging. ventricular function post myocardial infarction. Studies of the effect of Atrial fibrillation, fish oil derived omega-3 polyunsaturated fatty acids, polyunsaturated fatty tissue re-modelling, fibrosis, acids (EPA and DHA), and hypertrophy. omega-6 fatty acids on experimental atrial fibrillation, and mechanisms of their antiarrhythmic effects. Dynamic micro-ct for Three-dimensional micro pre-clinical cardiac imaging. computed tomography, murine cardiac imaging, myocardial remodeling, heart failure, cardiac function. Incretin action and the Diabetes, peptide hormones, cardiovascular system. GLP-1, DPP-4, incretins. Examination of the novel Tie2, angiopoietin, signalling, angiopoietin peptide mimetic atherosclerosis, limb vasculotide as a treatment ischemia. for atherosclerosis and limb ischemia. Molecular studies examining Tie2, lymphangiogenesis, the role of lymphangiogenic proteomics, transgenic, signalling heart disease. signalling. Engaging in valued activities Stroke survivors, participation, post stroke. longitudinal study, transformative learning, rehabilitation. Thrombotic mechanisms Myocardial infarction, stroke, as predictors of vascular hypercoagulability, platelets events In non-cardiac surgery coagulation. patients cohort evaluation (ThromboVISION) , ,322 I 116, ,388 I , ,875 I 109, ,100 I 83,000 83,000 I 91,000 91,000 I Principal Investigator and Co-Investigator(s) Dick, Alexander J.; Stewart, Duncan J.; Parker, Thomas G.; Courtman, David W.; Leong-Poi, Howard M.; Cunningham, Charles H. Dorian, Paul; Mangat, Iqwal Drangova, Maria; Feng, Qingping Drucker, Daniel J.; Husain, Mansoor Dumont, Daniel J. Dumont, Daniel J. Egan, Mary Y.; Dubouloz, Claire- Jehanne; Davis, Christopher G.; Kessler, Dorothy E. Eikelboom, John W.A.; Weitz, Jeffrey I.; Cook, Deborah J.; Devereaux, Philip J.; McQueen, Matthew J.; Gerstein, Hertzel C.; Hill, Stephen A.; Kavsak, Peter A.; Punthakee, Zubin; Thabane, Lehana 47,287 94,574 II,IV 130, ,235 II Themes I: Basic Biomedical II: Clinical III: Health Services/Systems IV: Population Health 75

82 Heart and Stroke Foundation Research Report Principal Investigator and Co-Investigator(s) Emili, Andrew; Gramolini, Anthony O. Epand, Richard M. Eubanks, James H.; Mills, Linda R.; Nash, Joanne E. Fehlings, Michael G.; Velumian, Alexander A. Feldman, Ross D.; Gros, Robert Feng, Qingping Feng, Qingping; Xenocostas, Anargyros Ferguson, Alastair V. Ferguson, Stephen S.G. Floras, John S.; Bradley, T. Douglas Floras, John S.; Harvey, Paula J. Institute of Principal Investigator Toronto McMaster Toronto Western Research Institute Health Network Western Ontario Western Ontario London Health Sciences Centre Queen's Robarts Research Institute Toronto General Hospital Toronto General Hospital Project Keywords Term $ Cumulative Theme $ to Mechanistic investigation of microrna-mediated regulation of dilated cardiomyopathy Cardiac disease, microrna, proteomics, bioinformatics, cardiomyopathy, shrna. (DCM). Mechanism of action of potent Thrombosis, apo A-I mimetic antiatherogenic peptides. peptides, HDL, modified lipoproteins, procoagulant complex, protein C, oxidized lipids. Tha mammalian sirtuin SIRT3: Mitochondria, novel neuroprotective factor? neuroprotection, cell culture, fluorescence imaging, cell biology. The ischemic axon: cross-talk Myelinated axons, with myelin in K+ channel oligodendrocytes, glutamate terms. receptors, K+ channels, conduction block. Determinants of adenylyl Adenylyl cyclase, cellular cyclase-mediated vascular biology, hypertension, responses. molecular biology, vascular biology. Heart development in Heart development, diabetes, diabeties: role of nitric oxide. nitric oxide, septal defects, coronary artery development. Cardioprotection by Erythropoietin, nitric oxide erythropoietin: role of nitric synthase, apoptosis, heart oxide. failure, myocardial infarction. Adiponectin actions in Paraventricular nucleus, area autonomic control centres of postrema, adiponectin, patch the brain. clamp. Regulation of G proteincoupled Small G proteins, receptor signaling angiotensin, beta-adrenergic desensitization and receptor, desensitization, resensitization. resensitization, protein kinases. Central regulation of Heart failure, obstructive autonomic cardiovascular sleep apnea, functional function in human heart failure magnetic resonance imaging, and sleep apnea. heart rate variability, muscle sympathetic nerve activity. Neural regulation of the Autonomic nervous system, circulation in human heart heart failure, heart rate failure and hypertension. variability, microneurography, sympathetic nervous system , ,134 I,II 65,000 65,000 I 76,619 76,619 I , ,167 I 148, ,051 I,II,IV 123, ,473 I , ,487 I , ,711 I , ,378 I , ,498 I,II , ,949 I,II 76

83 Heart and Stroke Foundation Research Report Principal Investigator and Co-Investigator(s) Fowler, Robert A.; Mittmann, Nicole; Cook, Deborah J.; Dodek, Peter M.; Gould, Michael K.; Geerts, William H.; Guyatt, Gordon H. Fremes, Stephen E.; Novick, Richard J.; Whitlock, Richard P.; Chu, Michael W.A.; Singh, Steve K.; de Souza, Domingos S.R.; Dashwood, Michael R.; Fedak, Paul W.M.; Kachel, Erez; Verma, Subodh; Viola, Nicola Gagnon, France; Wells, Philip S.; Bulman, Dennis E. Gaisano, Herbert Y. Giacca, Adria; Fantus, Ivan G.; Bendeck, Michelle P. Goldfield, Gary S.; Adamo, Kristi Bree Gorczynski, Reginald M. Grace, Sherry L.; Brister, Stephanie J.; Arthur, Heather M.; Pilote, Louise; Stewart, Donna E.; Melvin, Kenneth R.; Sternberg, Leonard; Oh, Paul I.T. Institute of Principal Investigator Sunnybrook Health Sciences Centre Sunnybrook Health Sciences Centre Toronto Toronto Toronto Children's Hospital of Eastern Ontario Health Network Toronto General Hospital Project Keywords Term $ Cumulative Theme $ to E-PROTECT: prospective Thromboembolism, economic analysis in prophylaxis, cost, economic, the prophylaxis for burden. thromboembolism in critical care trial. Surgical and pharmacological Bypass surgery, graft novel intervention to improve patency, clinical trial, fish oil, overall results of saphenous saphenous veins. vein graft patency in coronary artery bypass grafting surgery: An international multi-centre randomized controlled clincial trial (Superior SVG Patency CABG trial). Genome-wide search for Thrombosis, genetic oligogenes in factor V leiden epidemiology, quantitative thrombophilia. traits, thrombophilia, complex disease. SNARE regulation of cardiac ATP-sensitive potassium sulfonylurea receptor, a novel channels, SNARE proteins, drug target for cardiac ishemia. electrophysiology, cardiac myocytes, protein interactions. Vasculoprotective effect of Hyperinsulinemia, insulin insulin in vivo. resistance, restenosis, apo E-null mouse, atherosclerosis. Behavioural engineering of Physical activity, obesity, physical activity in obese children, television, sedentary children: a randomized behaviour. controlled trial. Regulation of transplant CD200, transplantation, rejection and inflammation immunoregulation, by soluble mediators of inflammation, CD200:CD200R interaction. immunotherapy. An RCT of women's Cardiac rehabilitation, adherence to women-only, women, program model, home-based and traditional adherence, exercise capacity. cardiac rehabilitation (Cardiac Rehabilitation for Her Heart Event Recovery CR4HER) , ,208 II,III,IV 65,860 65,860 II , ,828 I,II, IV , ,585 I , ,427 I,II 80,558 80,558 II 89,314 89,314 I,II 108, ,179 II,III,IV Themes I: Basic Biomedical II: Clinical III: Health Services/Systems IV: Population Health 77

84 Heart and Stroke Foundation Research Report Principal Investigator Institute of Principal and Co-Investigator(s) Investigator Gramolini, Anthony O. Toronto Grant, David; Toronto General Levy, Gary; Hospital Phillips, James M.; Gorczynski, Reginald M.; Adamson, S. Lee Gross, Peter L. McMaster Grover, Ashok K. McMaster Gruenwald, Hospital for Sick Colleen; Children Chan, Anthony K.C.; Van Arsdell, Glen S.; Holtby, Helen M.; McCrindle, Brian W.; Brandao, Leonardo R.; Manlhiot, Cedric Gula, Lorne J.; London Health Krahn, Andrew D.; Sciences Centre Suskin, Neville G. Project Keywords Term $ Cumulative Theme $ to Investigation of phospholamban mutations, sarcoplasmic reticulum calcium defects, and dilated Cardiac disease, calcium signaling, intracellular trafficking, endoplasmic reticulum (ER) stress. cardiomyopathy. fgl2/fgl2 and xenograft Thrombosis, transplantation, transplantation. macrophage, endothelial cells, fibrin. Defining how atorvastatin Statins, animal model, inhibits platelets. thrombosis, S-nitrosylation, prenylation. Caloxins: novel inhibitors of Calcium pumps, phage plasma membrane calcium display, drug discovery, pumps. cardiovascular. Antithrombin enhancement Antithrombin, coagulation, may improve anticoagulation heparin, cardiopulmonary efficiency in infants undergoing bypass, infant heart surgery. cardiopulmonary bypass for cardiac surgery. Monitoring of ventricular Implanted cardioverterdefibrillator, rhythm & exercise - ICD study exercise, cardiac (MOVE-IT). rehabilitation, arrhythmia, risk , ,959 I,II , ,800 I 80, ,000 I , ,210 I 70,000 70,000 II 72, ,042 II,IV Haas, Tara L. York Roles of protease inhibitors in Angiogenesis, shear stress, 80,660 80,660 I skeletal muscle microvascular remodelling. proteases, ischemia, gene expression. Hammond, James Role of nucleoside/nucleobase Adenosine, transporters, , ,785 I R. Western Ontario transporters in the regulation of the vascular effects of adenosine and its metabolites. ischemia, vasodilators, hypoxanthine. Harper, Mary-Ellen; Implications of AMPK-gamma Glycogen storage, 95,180 95,180 I,II Gollob, Michael H. Ottawa mutations for cardiac and skeletal muscle mitochondrial energetics. mitochondriogenesis, cardiomyocytes, primary muscle cells, mouse models. Hayward, Catherine P.M.; Doble, Bradley W. McMaster Functions of multimerin 1 as a platelet adhesive protein. Platelet adhesion, aggregation, platelet-rich thrombosus formation, arterial thrombosis, multimerin 1. 80, ,000 I 78

85 Heart and Stroke Foundation Research Report Principal Investigator and Co-Investigator(s) Heckman, George A.W.; Kaasalainen, Sharon J.; Stolee, Paul; Demers, Catherine; McKelvie, Robert S.; Strachan, Patricia H.; Kelley, Mary Louise I.; Habjan, Sonja; van der Horst, Mary-Lou A.; Tjam, Erin Y. Hegele, Robert A. Hegele, Robert A. Heximer, Scott P. Hinek, Aleksander Hinz, Boris Holden, Rachel M.; Adams, Michael A. Holdsworth, David W.; Poepping, Tamie L.; Rankin, Richard N. Hou, Sheng T. Institute of Principal Investigator McMaster Western Ontario Robarts Research Institute Toronto Hospital for Sick Children Toronto Queen's Robarts Research Institute National Research Council of Canada (Ottawa) Project Keywords Term $ Cumulative Theme $ to Adapting the Canadian Cardiovascular Society recommendations on heart Heart failure, long-term care, elderly, guidelines, consensus. failure: a consensus-based approach with stakeholder input. Genomics of Atherosclerosis, dyslipidemia, hypertriglyceridemia. triglycerides, genetics, DNA. Phenomics and genomics of Atherosclerosis, dyslipidemia, atherosclerosis in monogenic diabetes, metabolic metabolic syndrome. syndrome, genetics. Defining the molecular RGS proteins, sinoatrial node pathways through which RGS4 myocyte, parasympathetic regulates parasympathetic activity, autorhythmicity. signaling and heart rate control in sinoatrial node myocytes. Elastin and elastin receptor Elastin, elastin receptor, as crucial factors modulating arterial smooth muscle cells, cellular functions in cellular proliferation, pediatric cardiovascular development diseases with arterial and diseases. occulsions. Mechanical activation of a Cardiac hypertrophy, pro-fibrotic growth factor integrins, cardiac fibroblast, in cardiac myofibroblast transforming growth factor differentiation and heart beta, issue stiffness. fibrosis. Mechanisms of vascular Cardiovascular disease calcification (VC) in a model of (CVD), animal model, chronic chronic kidney disease (CKD). kidney disease (CKD), vascular calcification (VC), hemodynamics. Investigation of flow in the Stroke, carotid bifurcation stenosed carotid bifurcation. disease, doppler ultrasound, hemodynamics, artery-toartery embolization. Investigation of SEMA3A's role Stroke, long term recovery, in angiogenesis and vascular axonal damage, semaphorins, permeability during stroke neuropilins. recovery. 79, ,359 III 164, ,446 I,II,IV , ,729 I,II,IV , ,175 I , ,026 I 75,500 75,500 I 88, ,866 I , ,069 I,II 72, ,491 I Themes I: Basic Biomedical II: Clinical III: Health Services/Systems IV: Population Health 79

86 Heart and Stroke Foundation Research Report Principal Investigator and Co-Investigator(s) Hough, Margaret R.; Dick, Alexander J. Huff, Murray W. Husain, Mansoor Husain, Mansoor; Drucker, Daniel J Ikura, Mitsuhiko Ikura, Mitsuhiko Karkouti, Keyvan; Chan, Christopher T. Karmazyn, Morris Karmazyn, Morris Kassner, Andrea; Mikulis, David.J.; Silver, Frank L.; Yeung, Rae S.M. Institute of Principal Investigator Sunnybrook Health Sciences Centre Robarts Research Institute Toronto General Hospital Toronto General Hospital Health Network Ontario Cancer Institute Toronto General Hospital Western Ontario Western Ontario Hospital for Sick Children Project Keywords Term $ Cumulative Theme $ to Cardiac repair and regeneration. Stem cells, in vitro differentiation, cardiovascular progenitors, magnetic resonance imaging (MRI). Regulation of ApoB Atherosclerosis, lipoprotein metabolism: relationship to metabolism, insulin atherosclerosis. resistance, flavonoids, mouse models. Plasma membrane Ca2+ Calcium ATPase, cardiac ATPase 4 isoforms: regulation muscle, smooth muscle, and role in cardiac and smooth transcription regulation, muscle. alternative splicing. The role of glucagon-like Glucagon peptides & peptide-1 in cardiac health and receptors, myocardial disease. infarction, heart failure, transgenic mice, knockout mice. Structural basis for regulation Calcium signaling, signal of store-operated calcium entry transduction, structural in the circulation system. biology, ion channel, protein structure. Structural elucidation Ca2+ transport, structural of intracellular calcium biology, endoplasmic transporters. reticulum, molecular recognition, inositol phosphate. Advance targeted transfusion Cardiac surgery, acute kidney in anemic cardiac surgical injury, blood transfusion, patients for kidney protection: anemia, coagulopathy. a proof of concept pilot study. Nitric oxide as an endogenous Nitric oxide, hypertrophy, antihypertrophic factor. RhoA/ROCK, obesity, calcineurin. Role of adenosine in Adenosine, cardiomyocyte myocardial hypertrophy and hypertrophy, heart failure, heart failure. mitochondrial permeability transition, gender differences. Widening the therapeutic Blood-brain barrier, imaging, window in acute ischemic blood markers, prediction of stroke with blood-brain hemorrhage, stroke. barrier permeability imaging and its relationship with corresponding blood markers: implications for short and long-term outcomes. 80, ,500 I 132, ,760 I 118, ,348 I , ,380 I 113, ,400 I , ,985 I 36,001 98,102 II 75,700 75,700 I 83,488 83,488 I 68,245 68,245 I,II 80

87 Heart and Stroke Foundation Research Report Principal Investigator and Co-Investigator(s) Keeley, Fred W. Keith, Mary E.; Yan, Andrew T.; Liu, Peter P. Kelton, John G.; Larche, Mark; Arnold, Donald M.; Nazi, Ishac; Moore, Jane C. Khokha, Rama Kislinger, Thomas; Gramolini, Anthony O. Koschinsky, Marlys L. Koschinsky, Marlys L.; Boffa, Michael B.; Nesheim, Michael E. Krahn, Andrew D.; Gollob, Michael H.; Birnie, David H.; Chauhan, Vijay S.; Healey, Jeffrey; Simpson, Christopher S. Kuebler, Wolfgang M. Institute of Principal Investigator Hospital for Sick Children St. Michael's Hospital McMaster Ontario Cancer Institute Health Network Windsor Windsor Western Ontario St. Michael's Hospital Project Keywords Term $ Cumulative Theme $ to Recombinantly expressed elastin-like polypeptides as a novel tool for investigations Elastin, elastic tissue, blood vessels, extracellular matrix, biomaterials. of the structure, assembly and properties of elastin-like materials. A randomized controlled Thiamin, heart function, trial of the effect of thiamin cardiac MRI, clinical trial, supplementation on heart quality of life. function in ambulatory patients with heart failure. Platelet-mediated acute Platelets, immune, thrombotic disorders. thrombocytopenia, heparin, thrombosis. Molecular dissection of the TIMP deficiency, distinct functions of TIMP-3 metalloproteinase, cytokines, and TIMP-4 in heart disease. ECM, heart disease. Identification and Proteomics, bioinformatics, characterization of cell-surface cardiac disease, cell-surface associated proteins in the receptors. heart: applications of a novel proteomic strategy. The pathophysiology of Lp(a) Lipoprotein(a), in the arterial wall: effect apolipoprotein(a), kringles, of Apo(a) on vascular cell atherosclerosis, endothelial function. dysfunction. Modulation of the TAFI TAFI, fibrinolysis, pathway in health and disease: inflammation, transcription, mechanistic analysis of the mrna stability. regulation of TAFI gene expression in hepatic and extrahepatic cells. Inherited causes of sudden Genetics, sudden death, death: phenotype genotype phenotype, diagnosis, correlation. registry. Mast cells in vascular Pulmonary hpertension, left remodeling and pulmonary heart disease, mast cells, hypertension with left heart vascular remodeling, cell-cell disease. interaction. 131, ,057 I 126, ,486 I,II,IV 145, ,887 I,II 114, ,762 I , ,046 I , ,083 I , ,756 I 170, ,866 II 78,200 78,200 I Themes I: Basic Biomedical II: Clinical III: Health Services/Systems IV: Population Health 81

88 Heart and Stroke Foundation Research Report Principal Investigator and Co-Investigator(s) Lagace, Thomas A. Lanctôt, Krista L.; Herrmann, Nathan; Black, Sandra E.; Gladstone, David J.; Snaiderman, Abraham; Gao, Fuqiang; Aviv, Richard; Albert, Paul R. Le Foll, Bernard Lee, Jonathan M. Lee, Ting-Yim; Aviv, Richard; Black, Sandra E.; Gladstone, David J.; Symons, Sean P. Leenen, Frans H.H.; Ruzicka, Marcel; Davies, Ross A.; Ascah, Kathryn J.; Le May, Michel R. Leong-Poi, Howard M. Letarte, Michelle V. Lewis, Gary F. Leytin, Valery Institute of Principal Investigator Ottawa Heart Institute Sunnybrook Health Sciences Centre Centre for Addiction and Mental Health Ottawa Lawson Health Research Institute Ottawa Heart Institute St. Michael's Hospital Hospital for Sick Children Toronto General Hospital St. Michael's Hospital Project Keywords Term $ Cumulative Theme $ to 78, ,150 I,II , ,198 I,II 70,000 70,000 I Regulation of the PCSK9 Low-density lipoprotein binding interaction with LDL receptor, PCSK9, cholesterol, receptor. protein-protein interaction, in vitro. The role of cytokine-serotonin Stroke, depression, cognition, interactions in post-stroke cytokines, kunurenine. depression and cognitive symptoms. Role of ethanolamides in Reinstatement, anandamide, nicotine-seeking. endocannabinoid, oleoylethanolamide, palmitoylethanolamide, craving, relapse, nicotine seeking. The role of elongation factor Obesity, ovary, phospholipid, eef1a2 in obesity. signaling, metabolism. Prediction of hemorrhagic Stroke, hemorrhagic transformation of ishemic transformation, thrombolysis, stroke with CT perfusion tissue plasminogen activator derived blood-brain-barrier (tpa), blood-brain-barrier permeability surface area (BBB), permeability surface product. product. RAS blockade and sympathetic Brain, heart, reninangiotensin-aldosterone activity in humans post MI. system, heart failure, blockers, sympathetic nerve activity. Role of statins in progenitor Chronic ischemia, progenitor cell therapy for chronic cells, statins, angiogenesis. ischemia. Soluble endoglin in endothelial TGF-B, endothelial cell function and hypertension dysfunction, hypertension, associated with preeclampsia. preeclampsia, soluble receptors. The role of c-reactive protein C-reactive protein, human (CRP) in modulating insulin C-reactive protein transgenic action and insulin secretion. mice, insulin sensitivity, insulin secretion, euglycemic and hyperglycemic clamps. Mitochondrial control of Platelets, apoptosis, platelet apoptosis. mitochondria, mitochondrial transmembrane potential, Bcl-2 family proteins , ,396 I 90, ,770 I,II , ,859 II 74, ,268 I 116, ,580 I , ,400 I , ,363 I 82

89 Heart and Stroke Foundation Research Report Principal Investigator Institute of Principal Project Keywords Term $ Cumulative Theme and Co-Investigator(s) Investigator $ to Li, Ren-Ke Toronto General Modifying cardiac repair Ischemic cardiomyopathy, 80, ,000 I Hospital using molecular and cellular interventions. gene and cell therapy, ultrasound microbubble imaging, cardiac function, extracellular matrix. Liaw, Patricia C.Y. McMaster Studies of the endothelial cell Protein C pathway, , ,480 I protein C receptor (EPCR). EPCR, thrombomodulin, endothelium, factor VIIa. Licht, Christoph Hospital for Sick Atypical hemolytic uremic Atypical HUS, complement 96, ,348 I,II P.B.; Kahr, Walter Children syndrome: a new pathological role for complement and coagulation control in platelets. system, factor H, platelets, clot formation. Lillicrap, David P. Queen's Age-related pathophysiology Thrombosis, von Willebrand 72,635 72,635 I,II of von Willebrand factor. factor, molecular biology, animal models. Lillicrap, David P.; Othman, Maha Queen's Gain-of-function mutants affecting the glycoprotein Ib/von Willebrand factor interaction: Potential novel antithrombotic molecules. Thrombosis, von Willebrand factor, platelets, antithrombotic , ,009 I Linkins, Lori- Ann; Warkentin, Theodore E.; Bates, Shannon M.; Heddle, Nancy M; Lee, Agnes Y.Y.; Liu, Yang McMaster Evaluation of a diagnostic strategy for patients with suspected heparin-induced thrombocytopenia (HIT). Heparin-induced thrombocytopenia, clinical prediction rule, thromboembolism. Liu, Fang Centre for Functional and molecular AMPA receptors, Addiction and characterization of proteinprotein glyceraldehyde-3-phosphate- Mental Health interaction between dehydrogenase, neurotoxicity, AMPA receptors and GAPDH protein-protein interaction, (Glyceraldehyde-3-phosphate stroke. Dehydrogenase). Liu, Peter P. Toronto General Danger signal, innate Innate immunity, heart failure, Research Institute immunity and cardiovascular inflammation, remodeling, inflammation. IRF-3. Liu, Peter P.; Medin, Health Strategies to optimize Heart failure, remodeling, Jeffrey A. Network mobilization, homing, and cytokines, stem cells, reconstitution therapy in progenitor cells, homing, cardiac repair post-infarction. innate immunity. Logan, Alexander Mount Sinai Disturbed sleep and drug Hypertension, obstructive G.; Bradley, T. Hospital resistant hypertension: a sleep apnea, physical activity, Douglas pathophysiological study. dietary sodium, sleep deprivation. Mak, Alan S. Queen's Cortactin and caldesmon in Smooth muscle, cell motility, vascular smooth muscle cell atherosclerosis, biochemistry, migration and invasion. cell biology. 39, ,716 II , ,900 I 75,460 75,460 I,II 80, ,000 I,II 59,729 59,729 II , ,502 I Themes I: Basic Biomedical II: Clinical III: Health Services/Systems IV: Population Health 83

90 Heart and Stroke Foundation Research Report Principal Investigator Institute of Principal and Co-Investigator(s) Investigator Mak, Susanna Mount Sinai Hospital Mak, Susanna; Mount Sinai Granton, John T.; Hospital Floras, John S.; Azevedo, Eduardo R.; Parker, John D. Marcel, Yves L. Ottawa Heart Institute Marcel, Yves L. Ottawa Heart Institute Marsden, Philip A. Toronto Marsden, Philip A. Toronto Martino, Tami A. Toronto Maunder, Robert G.; Mount Sinai Angus, Jan E.; Cho, Hospital Christine; Newton, Gary E.; Nolan, Robert P. Project Keywords Term $ Cumulative Theme $ to Sex determinants of left ventricular mechanical performance in humans with Sex, ventricular function, contractility, heart failure, human. and without heart failure. Studies of sympathetic nervous Autonomic physiology, system activation in patients norepinephrine, with pulmonary arterial microneurography, pulmonary hypertension. hypertension. Low HDL syndromes and the Lipoproteins, HDL, inflamed monocytes. inflammation, leucocytes, genetics. The role of the innate immune Atherosclerosis, LDLr -/- mice, system in atherosclerosis: laser capture microdissection, Further defining the role of microarray analysis, histology. NKT cells, interferon-gamma and IL-4 in the disease process. Post-transcriptional regulation Nitric oxide, endothelium, of endothelial gene expression. atherosclerosis, transcription, translation. Regulated expression of the Atherosclerosis, hypoxia, human nnos gene. translation, nitric oxide, transcription. Circadian control of cardiac Circadian rhythm, diurnal remodeling. rhythm, myocardial infarction, biomarkers, genomics and proteomics. The impact of close Heart failure, health interpersonal relationships and behaviour, social support, social support on heart failure. prospective study, mixed quantitative-qualitative methods , ,281 I,II , ,788 I,II 80, ,000 I,II , ,968 I 129, ,830 I , ,240 I , ,681 I,II 104, ,020 I,II Maurice, Donald H. Queen's Phosphodiesterases in arteries. Phosphodiesterase, camp, , ,398 I artery, smoothe muscle, restenosis. McBride, Heidi M. Mechanism and function of Mitochondrial dynamics, , ,606 I Ottawa Heart Institute mitochondrial derived vesicles. vesicles, ros-induced damage, intracellular transport. McCrindle, Brian W.; Russell, Jennifer L.; Dettmer, Elizabeth L.; Longmuir, Patricia E.; Faulkner, Guy E.J. Hospital for Sick Children Increasing physical activity among children with congenital heart defects. Clinical trial, congenital heart defect, child, physical activity, behaviour change. 208, ,107 II 84

91 Heart and Stroke Foundation Research Report Principal Investigator and Co-Investigator(s) McCulloch, Christopher A.G. McCulloch, Christopher A.G. McDermott, John C. McGuigan, Alison P. McPherson, Ruth Mehta, Sanjay Mielniczuk, Lisa M.; Dennie, Carole J.; DaSilva, Jean N.; Stewart, Duncan J.; Davies, Ross A.; Haddad, Haissam; Beanlands, Rob S.B.; de Kemp, Robert A.; Wells, George A. Min, Wei-Ping Min, Wei-Ping; Zheng, Xiufen Monnier, Philippe P. Morshead, Cindi M.; Shoichet, Molly S.; Corbett, Dale R. Institute of Principal Investigator Toronto Toronto York Toronto Ottawa Heart Institute Lawson Health Research Institute Ottawa Heart Institute London Health Sciences Centre London Health Sciences Centre Toronto Western Research Institute Toronto Project Keywords Term $ Cumulative Theme $ to Regulation of myofibroblast differentitation by mechanical loading. Role of intercellular adhesions in diabetic cardiomyopathy. Regulation of vascular smooth muscle gene expression by MEF2. Exploiting planar cell polarity signaling to engineer tissueengineered blood vessels. Genotype to phenotype: functional analysis of CHD genetic variants. Complex regulation of microvascular endothelial cell function in sepsis. Right ventricular substrate metabolism as a predictor of right heart failure in patients with pulmonary arterial hypertension. Preventing heart graft rejection by inhibiting innate and adaptive alloimmunity through gene silencing of toll-like receptors. Preventing heart graft rejection through interrupting CD40-CD40L pathway by cell-specific gene silencing. Repulsive guidance molecule (RGMa) has multiple inhibitory activities that haper neuronal regeneration after stroke. The development of drug and cell delivery systems for use in cell based therapies to treat stroke Cardiac hypertrophy, force, smooth muscle actin, actin binding proteins, fibrosis. Cadherins, fibroblasts, syncytia, fibrosis, heart failure. MEF2, smooth muscle, phenotype modulation, c-jun, myocardin, gene expression. Endothelial cell, microfluidics, planar cell polarity, tissueengineering, vascular graft. 94,200 94,200 I 95, ,620 I 92,136 92,136 I 77,400 77,400 I Inflammation/sepsis, microvascular endothelium, alveolar epithelium, macrophages, cell signaling, leukocytes. Pulmonary hypertension, heart failure, cardiac PET, cardiac MRI, cardiac metabolism. Heart transplantation, gene silencing, sirna, toll-like receptor (TLR), immune rejection. Heart transplantation, sirna, gene silencing, CD40-CD40L, immunoliposome. Axonal regeneration, RGMa, outgrowth inhibition, brain ischemia, antibodies. Drug and cell delivery; neural stem cells; transplantation; endogenous stimulation; rehabilitation. Atherosclerosis, genen, 9p21. 78, ,907 I,II , ,632 I 66,469 66,469 I,II 79, ,020 I 71,010 71,010 I 59,180 59,180 I , ,285 I Themes I: Basic Biomedical II: Clinical III: Health Services/Systems IV: Population Health 85

92 Heart and Stroke Foundation Research Report Principal Investigator and Co-Investigator(s) Nanthakumar, Kumaraswamy; Silverman, Frances S. Nanthakumar, Kumaraswamy; Yau, Terrence M.; Backx, Peter H. Nemer, Mona Ng, Dominic S. Ni, Heyu Nurse, Colin A. O'Brien, Edward R.M. O'Donnell, Martin J.; Mente, Andrew; Chow, Clara K.; Dehghan, Mahshid; Yusuf, Salim; McQueen, Matthew J.; Islam, Shofiqul M.; Teo, Koon K. Opas, Michal Pare, Guillaume; Anand, Sonia S.; O'Donnell, Martin J.; Xie, Changchun; Yusuf, Salim Park, David S. Institute of Principal Investigator Health Network Health Network Ottawa St. Michael's Hospital St. Michael's Hospital McMaster Ottawa Heart Institute McMaster Toronto McMaster Ottawa Project Keywords Term $ Cumulative Theme $ to Modulation of spatial-temporal dispersion of human myocardial repolarization by air pollution. Occupational health, electrophysiology, cardiac arrhythmias, pollution, environment. Electrophysiological Cardiomyocyte implications of regenerative transplantation, regenerative therapy. medicine, electrophysiology. Mechanisms of TBX5 action in Heart development, the heart. transcription factors, endocardium, transgenic mice, congenital heart disease. Regulation of lipids, insulin LCAT, HDL, ER stress, action and cell stress in LCAT atherosclerosis, inslulin stress. deficient mice. Novel mechanisms of platelet Platelet, thrombosis, integrin, aggregation: unveiling new hemostasis, vascular biology. roles of non-classical beta3 integrin ligands in thrombosis and hemostasis. Functional and anatomical O2-receptors, culture, patch characterization of rat aortic clamp, Ca2+ imaging, body chemoreceptors. immunofluorescence. Extracellular and intracellular Estrogen, receptor, vascular roles of HSP27: an atherosclerosis, hormone, estrogen receptor beta women. associated heat shock protein. Sodium intake and Sodium intake, measurement, cardiovascular disease in population health, diverse populations. cardiovascular prevention, nutrition. The role of calreticulin in Cardiac hypertrophy, dilated cardiac remodelling. myopathy, calreticulin, calcium, adhesion, ES cells. Understanding the contribution Stroke, genetics, of genetic variants to stroke risk cerebrovascular prevention. in a multi-ethnic population: the interstroke genetics study. Mechanism of delayed death CDK stroke, ischemia, in stroke. Puralpha, E2F. 92,565 92,565 II 90, ,350 I , ,588 I , ,954 I,II , ,288 I 77, ,700 I,II,III,IV , ,144 I,II 105, ,256 IV 68, ,243 I 118, ,669 I,II,IV 136, ,053 I 86

93 Heart and Stroke Foundation Research Report Principal Investigator and Co-Investigator(s) Park, David S. Parker, John D. Parker, Thomas G. Parkinson, John; Keeley, Fred W. Peng, Tianqing Peng, Tianqing Pickering, J. Geoffrey Pilote, Louise; Karp, Igor; Bacon, Simon L.; Chalifour, Lorraine E.; Cox, Jafna L.; Dasgupta, Kaberi; Daskalopoulou, Styliani-Stella; Eisenberg, Mark J.; Engert, James C.; Ghali, William A.; Hamet, Pavel; Humphries, Karin H.; Khan, Nadia A.; Lavoie, Kim L.; Norris, Colleen M.; Rabi, Doreen M.; Stark, Ken D.; Tagalakis, Vicky; Tremblay, André; Tu, Jack V. Institute of Principal Investigator Ottawa Mount Sinai Hospital St. Michael's Hospital Hospital for Sick Children London Health Sciences Centre London Health Sciences Centre Robarts Research Institute McGill Project Keywords Term $ Cumulative Theme $ to Oxidative stress and ischemic death. DJ-1, PRDZX2, oxidative stress, ROS, NRF2. Development of a new Endothelial function, vascular technique to assess endothelial ultrasound, flow mediated function: flow mediated dilation, nitric oxide sythase. constriction. EF-hand proteins, S100A1 Cardiac hypertrophy, and A6, in cardiovascular hypertension, calciumbinding pathophysiology. proteins, gene expression, apoptosis. An interdisciplinary Elastin, population genetics, approach to identifying and sequence variation, computer characterizing polymorphisms simulation, bioinformatics. in tropoelastin and their role in late onset cardiovascular disease. Role of calpain activation in Sepsis, heart function, myocardial dysfunction in calpain, caspase-3, sepsis. cardiomyocytes. Targeting mitochondial redox Sepsis, heart function, signaling to prevent myocardial TNF-alpha, apoptosis, dysfunction in sepsis. mitochondria redox signaling. Control of smooth muscle Vascular smooth muscle cell motility and vascular cell, cell migration, vascular stabilization. remodeling, angiogenesis, NAD biosynthesis. Genesis praxy: Gender and sex Cardiovascular disease; determinants of cardiovascular gender and sex differences; disease from bench to beyond premature acute coronary in premature acute coronary syndrome; risk factors; syndrome determinants of health , ,452 I , ,012 I,II , ,546 I 113, ,339 I,IV , ,033 I 110, ,510 I , ,530 I , ,572 II, III, IV Themes I: Basic Biomedical II: Clinical III: Health Services/Systems IV: Population Health 87

94 Heart and Stroke Foundation Research Report Principal Investigator and Co-Investigator(s) Pipe, Andrew L.; Reid, Robert D.; Mark, Amy E.; Tulloch, Heather E.; Aitken, Debbie Anne; Papadakis, Sophia; Mullen, Kerri-Anne Prado, Marco A.M. Prasad, Ramesh; Connelly, Philip W.; Wald, Ron; Kirpalani, Anish; Kim, Sang J.; Lok, Charmaine E.; Wald, Rachel M. Radisic, Milica; Li, Ren-Ke Rand, Margaret L. Rao, Vivek; Delgado, Diego H. Redington, Andrew N.; McCrindle, Brian W.; Caldarone, Christopher A.; Coles, John G.; Holtby, Helen M.; Ly, Linh G.; Scherer, Stephen W.; Schwartz, Steven M.; Van Arsdell, Glen S. Institute of Principal Investigator Ottawa Heart Institute Robarts Research Institute St. Michael's Hospital Toronto Hospital for Sick Children Health Network Hospital for Sick Children Project Keywords Term $ Cumulative Theme $ to Self directed titrated nicotine patch versus standard treatment for smoking cessation in smokers motivated to quit. Smoking cessation, transdermal nicotine patch therapy, randomized control trial, titrated dose, withdrawal. Decreased cholinergic tone Parasympathetic, cholinergic and heart dysfunction. tone, heart failure, cholinergic transporters. Impact of minimal Left ventricular hypertrophy, steroid-based kidney cardiac magnetic resonance, transplantation on ventricular biomarkers, transplantation, remodeling and function in renal disease. end-stage renal disease. Chitosan hydrogel with Cell therapy, infarcted immobilized growth factors myocardium, for cell therapy in myocardial photocrosslinkable hydrogel, infarction. chitosan, mouse embryonic stem cell, tissue engineering. The procoagulant surface Platelets, thrombosis, of activated platelets: procoagulant activity, development and persistence phosphatidylserine, calcium. in vitro and in vivo. EGFL-7, rapamycin and Endothelial injury, rapamycin, transplant vasculopathy. vasculopathy, telomerase, growth factors. The effect of remote ischemic Remote ischemic preconditioning on clinical and preconditioning, genomic responses to open ischemia-reperfusion injury, heart surgery in children. congenital heart disease, paediatric cardiac surgery, cardiopulmonary bypass. 125, ,000 II,III,IV 126, ,576 I ,101 78,101 II 70,216 70,216 I 79,821 79,821 I 61, ,030 I 167, ,099 I,II 88

95 Heart and Stroke Foundation Research Report Institute of Principal Investigator Ottawa Heart Institute Mount Sinai Hospital Health Network Toronto Ottawa Health Research Institute Health Network Project Keywords Term $ Cumulative Theme $ to Efficacy and cost-effectiveness of cost-free pharmacotherapy for smoking cessation for Cerebrovascular, stroke, secondary prevention, smoking, pharmacotherapy. high-risk smokers with cerebrovascular disease. The early natural history of Women's health, cardiovascular disease at cardiovascular disease, 4-years postpartum in young gestational diabetes, women with varying degrees dysglycemia, endothelial of glucose intolerance in function. pregnancy. Interaction between vascular Pancreatic islet, endothelial endothelial cells and pancreatic cell, fibroblast growth factor, beta-cells: understanding the two-photon microscopy, role of fibroblast growth factor microfluidics. (FGF). The effects of intensity on a Aphasia, anomia, treatment for naming deficits in rehabilitation, neuroimaging, aphasia and associated neural communication. underpinnings. Recurrent venous Venous thromboembolism, thromboembolism risk recurrence, long term stratification evaluation follow-up, vitamin K (REVERSE): Long term antagonist. follow-up to define if lifelong anticoagulation is required in high risk patients with a first unprovoked venous thromboembolism. The molecular basis for starch Obesity, starch digestion, digestion in the intestine: glycosyl hydrolases, human maltase-glucoamylase enzyme inhibitors, x-ray and sucrase-isomaltase. crystallography. Principal Investigator and Co-Investigator(s) Reid, Robert D.; Sharma, Mukul; Pipe, Andrew L.; Papadakis, Sophia; Moroz, Isabella A.; Gocan, Sophia J.; Aitken, Debbie Anne; Mullen, Kerri- Anne; Laplante, Mary Ann C. Retnakaran, Ravi R.; Floras, John S.; Connelly, Philip W.; Sermer, Mathew; Zinman, Bernard; Hanley, Anthony J.G. Rocheleau, Jonathan V. Rochon, Elizabeth A.; Leonard, Carol L.; Graham, Simon J.; Grady, Cheryl L. Rodger, Marc A.; Wells, Philip S.; Kahn, Susan R.; Carrier, Marc; Kovacs, Michael J.; Le Gal, Grégoire; Anderson, David R.; Solymoss, Susan; Ramsay, Timothy O.; Betancourt, Marisol T. Rose, David R. 223, ,487 II,III,IV 60, ,130 I,II 87, ,534 I 86,304 86,304 I,II 110, ,214 II , ,812 I,II,III,IV Themes I: Basic Biomedical II: Clinical III: Health Services/Systems IV: Population Health 89

96 Heart and Stroke Foundation Research Report Principal Investigator and Co-Investigator(s) Roy, Eric A.; Black, Sandra E.; Hebert, Deborah; Adams, Scott G.; Danckert, James A.; Park, Norman W.; McIlroy, William E.; Staines, W. Richard; Dixon, Michael J. Ruel, Marc; Beanlands, Rob S.B.; Suuronen, Erik J.; de Kemp, Robert A.; DaSilva, Jean N.; Veinot, John P. Rui, Tao Ruzicka, Marcel; McCormick, Brendan B.; Knoll, Greg A.; Leenen, Frans H.H.; Touyz, Rhian M.; Ripu, Jindal Schlichter, Lyanne C. Schlichter, Lyanne C. Shah, Baiju R.; Hux, Janet E.; Anand, Sonia S.; Manuel, Douglas G.; Austin, Peter C. Shaughnessy, Stephen G.; Young, Edward Sheffield, William P. Institute of Principal Investigator Waterloo Ottawa Heart Institute Lawson Health Research Institute Ottawa Toronto Western Research Institute Toronto Western Research Institute Institute for Clinical Evaluative Sciences McMaster McMaster Project Keywords Term $ Cumulative Theme $ to Neuropsychological profiles and neuroanatomic correlates of limb apraxia. Apraxia, cognition and action, brain imaging, stroke recovery, memory. Evaluation of biopolymer Tissue engineering, delivered EPCs for cardiac endothelial progenitor cells, repair in a swine model of hibernating myocardium, hibernating myocardium. animal models, PET. Role of HMGB1 in ischemia/ Ischemia/reperfusion reperfusion-induced injury, HMGB1, apoptosis, myocardial injury. cell signaling, myocardial dysfunction. Sympathetic activity in patients MSNA, sympathetic activity, with end-stage renal disease peritoneal dialysis. on peritoneal dialysis. Modulating modes of Neuroinflammation, stroke microglial activation to reduce model, microglial cells, secondary stroke injury. molecule/protein expression, cell functions, potassium channels. Pathophysiology and Neuroinflammation, ICH inflammation after intracerebral model, immune cells, hemmorhage. molecule expression, protein expression. Diabetes care and outcomes Ethnicity, visible minority for people with Chinese and groups, diabetes mellitus, South Asian origins. quality of care, health care utilization. Mechanism(s) of low molecular Low molecular weight weight heparin-induced bone heparins, osteoporosis, bone, loss. anticoagulants. Exploring engineered serpins Serpins, thrombosis, heparin as potential antithrombotic cofactor II, alpha-1-proteinase agents. inhibitor, thrombin , ,456 I,II 79, ,072 I , ,634 I 54,552 54,552 II 116, ,749 I , ,205 I , ,133 III,IV 80, ,000 I , ,483 I 90

97 Heart and Stroke Foundation Research Report Principal Investigator Institute of Principal and Co-Investigator(s) Investigator Sheffield, William P. McMaster Shoemaker, J. Kevin; Suskin, Western Ontario Neville G.; St. Lawrence, Keith S. Silversides, Candice Health K.; Siu, Samuel C.; Network Sermer, Mathew; Colman, Jack M. Simmons, Craig A. Toronto Slack, Ruth S. Ottawa Slack, Ruth S. Ottawa Project Keywords Term $ Cumulative Theme $ to Transforming hirudin into Hirudin, albumin, antiplasmin, an activatable, clot-localized coagulation, thrombosis. thrombin inhibitor. Plasticity of corticalcardiovascular interactions in cortical autonomic network, Coronary artery disease, vascular disease. sympathetic nerve activity, parasympathetic nervous system, vascular mechanics, cardiac rehabilitation. Investigation of the prognostic Heart disease, pregnancy, importance of natriuretic outcomes. peptides in pregnant women with heart disease: a prospective observational cohort study. The role of C-type natriuretic Heart valve sclerosis, peptide in cardiac valve myofibroblasts, fibrosis. mechanobiology, fibrosis, CNP. Manipulating mitochondrial Stroke, apoptosis, neurons, dynamics to promote brain mitochondrial, molecular. recovery after stroke. Regulation of MCL-1 to treat Stroke, apoptosis, neurons, stroke. transgenic mice, molecular. 98, ,422 I , ,268 I,II 69,970 69,970 II 89, ,473 I 102, ,384 I , ,077 I Smith, Steven P. Queen's The activation of TAFI and the TAFI, TAFIa, fibrinolysis, 88,521 88,521 I,III properties of TAFIa. thrombomodulin, endothelial cells. So, Derek Y.F.; Obstructive sleep apnea as Clopidogrel reactivity, 79, ,200 I,II Labinaz, Marino; Le May, Michel R.; Glover, Christopher A.; Wells, George A.; Chandy, George P.; Leech, Judith A. Ottawa Heart Institute a risk factor for clopidogrel unresponsiveness in patients undergoing percutaneous coronary intervention: prevalence, mechanisms and possible influence on clinical outcomes. sleep apnea, percutaneous coronary intervention. Sorisky, Alexander Ottawa Health MAPping adipose tissue Obesity, preadipocyte, 138, ,170 I,II Research Institute malfunction in obesity: macrophages, adipose cells and PDGF. adipocyte, macrophage, PDGF Spafford, J. David; Structure-function analyses of L-type calcium channels, , ,675 I Honek, John F. Waterloo drug interactions with L-type calcium channels. dihydropyridines, conopeptides, patch clamp electrophysiology, pharmacophore. Sparks, Daniel L. Ottawa Heart Institute The role of HDL in triglyceride metabolism. HDL, cholesterol, apolipoproteins, lipases, heart disease , ,000 I Themes I: Basic Biomedical II: Clinical III: Health Services/Systems IV: Population Health 91

98 Heart and Stroke Foundation Research Report Principal Investigator and Co-Investigator(s) St. Lawrence, Keith S.; Rylett, Rebecca Jane; Lee, Ting-Yim; Staples, James F.; Toronov, Vladislav Stagljar, Igor Steinman, David A. Stiell, Ian G.; Birnie, David H.; Perry, Jeffrey J.; Wells, George A.; Borgundvaag, Bjug; Brison, Robert J.; Dorian, Paul; Redfearn, Damian Paul P.; Rowe, Brian H.; Wyse, D. George Sugita, Shuzo Suskin, Neville G.; Reid, Robert D.; Prior, Peter L.; Chan, Richard K.T.; Hachinski, Vladimir; Gwadry-Sridhar, Femida H.; Pipe, Andrew L.; Sharma, Mukul Suuronen, Erik J.; Ruel, Marc; Cao, Xudong; DaSilva, Jean N.; Beanlands, Rob S.B.; dekemp, Robert; Whitman, Stewart C.; Veinot, John P. Institute of Principal Investigator Lawson Health Research Institute Toronto Toronto Ottawa Hospital Research Institute Toronto Western Hospital Lawson Health Research Institute Ottawa Heart Institute Project Keywords Term $ Cumulative Theme $ to Oxygen consumption is an early predictor of brain damage following hypoxiaischemia. Hypoxia ischemia, cerebral metabolic rate of oxygen, near-infrared spectroscopy, neonatal brain injury, brain energetics. Functional analysis of the Cardiovascular disease, interactome of the human ß-adrenergic receptors, ß-adrenergic receptors. protein-protein interactions, membrane yeast two-hybrid system, functional analysis B2-AR interactors. Flow in the common carotid Blood flow, carotid artery, artery is not fully-developed: Doppler ultrasound, implications for studies of atherosclerosis, magnetic atherosclerosis. resonance imaging. A prospective evaluation of Emergency medicine, the outcomes and quality of cardioversion, atrial life of emergency department fibrillation, atrial flutter, recent patients with recent-onset atrial onset atrial fibrillation or fibrillation and flutter (RAFF). flutter, quality of life. The roles of CAPS1 in Noradrenaline, catecholamine secretion. secretion, secretory granules, hypertension, pheochromocytoma. Comprehensive cardiac Cardiac rehabilitation, rehabilitation programming transient ischemic attack. for patients following transient ischemic attack (extension). Recruitment of endogenous Tissue engineering, circulating progenitor cells for endothelial progenitor cells, cardiac regeneration using regenerative medicine, stem enhanced tissue-engineered cell therapy, coronary artery biomatrices. disease. 88, ,460 I 92, ,653 I 47,023 94,046 I 100, ,743 II,III 78, ,237 I 157, ,288 II,III 130, ,310 I 92

99 Heart and Stroke Foundation Research Report Teo, Koon K.; Anand, Sonia S.; Atkinson, Stephanie A.; Bourgeois, Jacqueline M.; McDonald, Sarah D.; McQueen, Matthew J.; Morrison, Katherine M.; Pare, Guillaume; Pogue, Janice M.; Yusuf, Salim McMaster Early life origins of obesity and obesity-related disorders - The family cohort. Childhood obesity, longitudinal birth cohort, cardiovascular risk factors, insulin resistance, leptin. Tesson, Frederique; Cell nucleus and dilated Human molecular genetics, Ruel, Marc; Davies, Ottawa Heart cardiomyopathy. lamin A/C, SUMO, gene Ross A. Institute expression, cell nucleus, dilated cardiomyopathy. Tobe, Sheldon W.; Sunnybrook Harmony study (Hypertension Hypertension, relaxation Abbey, Susan E.; Health Sciences analysis of stress reduction therapy, behaviour therapy, Abramson, Beth L.; Centre using mindfulness meditation lifestyle adjustment, Baker, Brian; Irvine, and yoga). psychology. Marilyn Jane; Kiss, Alexander J.; Myers, Martin G. Touyz, Rhian M. TRPM7 signaling through Cation channels, magnesium, Ottawa lipid rafts in vascular smooth signal transduction, vascular muscle cells - implications in remodeling, hypertension, hypertension. vascular biology. Tsushima, Robert G. York Cell signaling in myocardial Heart, ischemia, reperfusion, ischemic preconditioning. cell signaling, transgenic mice. Principal Investigator Institute of Principal Project Keywords Term $ Cumulative Theme and Co-Investigator(s) Investigator $ to Sweeney, Gary York Cardioprotective effects of Adiponectin, metabolism, 80,000 80,000 I adiponectin. obesity, diabetes, cardiomyocyte. Tang, Damu McMaster Characterization of a novel insig binding protein (INsigBP1). Insig, insig binding protein, sterol regulatory element binding protein (SREBP), SCAP (SREBP cleavage activating protein), cholesterol homeostasis , ,500 I 158, ,133 IV 96, ,699 I,II , ,596 II,III,IV , ,366 I , ,100 I Tsushima, Robert York SNARE protein regulation of SNARE proteins, ion 101, ,500 I G.; Gaisano, Herbert Y. cardiac ion channels and ANF secretion. channels, ANF, exocytosis, knockout mice. Tulloch, Heather E.; Pipe, Andrew L.; Reid, Robert D.; Els, Charl Ottawa Heart Institute Interventions to reduce cardiovascular disease: "real-world" effectiveness of combined pharmacotherapy and behavioural counselling for smoking cessation. Smoking cessation, intervention, primary prevention, secondary prevention, effectiveness ,244 II,III,IV Themes I: Basic Biomedical II: Clinical III: Health Services/Systems IV: Population Health 93

100 Heart and Stroke Foundation Research Report Principal Investigator and Co-Investigator(s) Tymianski, Michael Tymianski, Michael Van Arsdell, Glen S.; Taylor, Katherine L.; Honjo, Osami; Merklinger, Sandra L.; Guerguerian, Anne-Marie Van Huysse, James W. Verma, Subodh Verma, Subodh von Harsdorf, Rudiger Walley, Keith R.; Murkin, John M. Wang, Hao Wang, Hao Warkentin, Theodore E. Ween, Jon Erik; Aviv, Richard; Black, Sandra E.; Gao, Fuqiang; Stuss, Donald T. Institute of Principal Investigator Health Network Health Network Hospital for Sick Children Ottawa Heart Institute St. Michael's Hospital St. Michael's Hospital Health Network London Health Sciences Centre Western Ontario Western Ontario McMaster Sunnybrook Health Sciences Centre Project Keywords Term $ Cumulative Theme $ to Differential gene response to cerebral ischemia in rats and non-human promates. Cerebral ischemia, cell death, non-human primates, rats, genes. Role of TRM7 channels in Myocardial ischemia, cell myocardial ischemia. death, animal models, transient receptor potential channels, cytoprotection. Mechanical lung assist as a Neonatal cardiac surgery, means to achieve primary single ventricle, lung in-series palliation for single maturation, cavopulmonary ventricle neonates: a proof of connection, mechanical concept study in noenates and assist. infants. Roles of the brain Na, Hypertension, Na, K-ATPase, K-ATPase alpha isoforms in the renin-angiotension system, regulation of blood pressure. CNS, ouabain-like substance. Elucidating the in vivo role of Adiponectin, inflammation, adiponectin in inflammation: knockout animals, leucocyte a biochemical and kinetics, intravital microscopy. pharmacological approach. Neuregulin-1 as a novel Neuregulin, endothelial treatment for endothelial function, atherosclerosis, dysfunction and PI3-kinase/Akt pathway. atherosclerosis. Evaluation of p21cip1/waf1 Cardiomyocytes, myocardial protein transduction as a novel infarction, hypertrophy, therapeutic approach in heart apoptosis, P21CIP1. failure. Genetic determinants of Cardiopulmonary bypass; neurocognitive dysfunction genes; polymorphism; following cardiopulmonary cognitive dysfunction. bypass Mechanisms of Heart transplantation, immunomodulation by mesenchymal stem cells, mesenchymal stem cells in tolerance, immunoregulatory cardiac allograft tolerance. cells, imaging. Soluble CD83 based therapy in Heart transplantation, soluble cardiac allograft tolerance. CD83, tolerance, dendritic cells, T regulatory cells. Heparin-induced Platelet, heparin, IgG, thrombocytopenia. thrombocytopenia, thrombosis. Refinement of a point-ofcare, Stroke, cognition, electronic testing assessment, dementia, tool for longitudinal stroke neurophysiology. assessments. 75,000 75,000 I 115, ,440 I 38,055 38,055 II , ,428 I 65, ,664 I 80, ,000 I , ,000 I , ,592 I, II 85,371 85,371 I , ,901 I 98,196 98,196 I,II 80, ,000 II,IV 94

101 Heart and Stroke Foundation Research Report Principal Investigator and Co-Investigator(s) Weitz, Jeffrey I. Wells, James W. Wells, Philip S.; Ramsay, Timothy O.; Kahn, Susan R.; Kearon, Clive ; Carson, Nancy L.; Anderson, David R.; Crowther, Mark A.; Kovacs, Michael J.; Rodger, Marc A. Wells, R. Glenn; Celler, Anna M.; de Kemp, Robert A.; Ruddy, Terrence D. Wen, Xiao-Yan; Ni, Heyu; Connelly, Philip W. Werstuck, Geoffrey H. White, James A.; Drangova, Maria; Wisenberg, Gerald; Siu, Samuel C.; Yee, Raymond Wilson, Gregory J.; Backx, Peter H. Yang, Burton B. Yang, Burton B. Institute of Principal Investigator Henderson Research Centre Toronto Ottawa Hospital Research Institute Ottawa Heart Institute Princess Margaret Hospital Henderson Research Centre London Health Sciences Centre Hospital for Sick Children Sunnybrook Health Sciences Centre Sunnybrook Health Sciences Centre Project Keywords Term $ Cumulative Theme $ to Impact of gamma' fibrinogen on clot formation and clot lysis at sites of plaque rupture. Coagulation, fibrinolysis, anticoagulants, plasminogen activators, thrombolysis. Nature of the signalling Heart disease, muscarinic complex between cardiac cholinergic receptor, G muscarinic receptors and G protein, co-operativity, proteins. oligomers, signalling mechanism. Development and validation Bleeding risk, of clinical prediction rules prediction rules, venous for bleeding for patients on thromboembolism, oral anticoagulant therapy for anticoagulants, singlenucleotide venous thromboembolism. polymorphisms. Respiratory motion Respiratory motion compensation in coronary correction, dedicated cardiac flow reverse measurements SPECT, heart disease, with CZT dedicated cardiac absolute Myocardial Blood single-photon emission Flow (MBF), Coronary Flow computed tomography. Reserve (CFR). Roles of novel lpdl and lpdlr Phospholipase A1, gene phospholipases in platelet targeting, thrombosis, activation and thrombosis. lysophosphatic acid, platelet. Investigating the role of Atherosclerosis, glycogen glycogen synthase kinase synthase kinase (GSK)-3, (GSK)-3 in accelerated endoplasmic reticulum (ER), atherosclerosis. stress, hyperglycemia, mouse models. Multi-modality imaging Cardiac resynchronization, assessment for pacing imaging, MRI, CT, tissue interventions in heart failure doppler. (MAPIT-HF). Remote ischemic Cardiomyocyte, ischemia, preconditioning: mechanisms reperfusion, preconditioning, of cardiomyocyte survival. remote. MicroRNA mir-378 regulates MicroRNA, self renewal, self renewal and angiogenesis. angiogenesis, proliferation, wound healing. Roles of mir-17-5p in Extracellular matrix, endothelial wound healing and proliferation, adhesion, angiogenesis. molecular biology, cell biology, angiogenesis, microrna , ,509 I , ,796 I , ,344 I,II,IV 78,254 78,254 II 118, ,251 I 81,000 81,000 I , ,390 II 73,560 73,560 I 103, ,440 I , ,180 I Themes I: Basic Biomedical II: Clinical III: Health Services/Systems IV: Population Health 95

102 Heart and Stroke Foundation Research Report Principal Investigator Institute of Principal and Co-Investigator(s) Investigator Yao, Zemin Ottawa Yao, Zemin Ottawa Yeung, Rae S.M. Hospital for Sick Children Zandstra, Peter W.; Husain, Mansoor; Toronto Radisic, Milica; Nanthakumar, Kumaraswamy Zha, Xiaohui Ottawa Hospital Research Institute Project Keywords Term $ Cumulative Theme $ to Analysis of non-truncating APOB mutations in human hypobetalipoproteinemia and Hypobetalipoproteinemia, hypocholesterolemia, apob, lipogenesis, triglycerides. hypocholesterolemia. Functional analysis of apoc-iii, hypotriglyceridemia, ApoC3 mutation in human lipoprotein, adenovirus, hypotriglyceridemia. transgenic mice. Towards a better Kawasaki disease, understanding of Kawasaki inflammation, T-cells, animal disease. model, autoimmunity. Interrogating the Bioengineering, cariomyocyte cardiomyogenic hierarchy to transplantation, regenerative optimize cardiovascular cell medicine, stem cells therapy. differentiation, proteomics, tissue engineering. Molecular mechanisms of ABCA1, signal transduction, calcineurin signaling in ABCA1 calcineurin, cholesterol efflux, function. cytokine. 71,200 71,200 I 90,584 90,584 I , ,158 I,II , ,400 I 84,500 84,500 I Zhang, Shetuan Queen's Control of cell surface channel 142, ,467 I density by potassium as a novel mechanism for herg regulation Zhang, Wandong; Modulation of MMP9 Stroke, ischemia/reperfusion, , ,540 I Zhang, Xia; Woulfe, John M. Ottawa expression induced by cerebral ischemia and reperfusion to reduce blood-brain barrier permeability and brain damage in ischemic stroke. MMP9 expression, BBB permeability, brain damage. Zhang, Zhu-Xu; Min, Wei-Ping; Jevnikar, Anthony M. Western Ontario Therapeutic potential and mechanism of double-negative regulatory T (DN-Treg) cells mediated tolerance in heart transplantation. Transplantation, double negative T cell, regulatory T cell, tolerance, mix chimerism. 92, ,060 I 96

103 Heart and Stroke Foundation Research Report Quebec Project Keywords Term $ Cumulative Theme $ to Determinants of progression of human aortic stiffness in renal failure: role of advanced glycation end products, Arterial stiffness, advanced glycation end-products, oxidative stress, inflammation, renal failure. oxidative stress, endotheline-1 and inflammation. Intracrine endothelin signaling Endothelin, heart, receptor, in the cardiac ventricular nucleus, signal transduction. myocyte. Regulation of connexin Connexin 43 channels, 43 channels by protein protein kinase C isoforms, kinase C: implication in protein kinase A, congenital the pathophysiology of heart diseases, cell oculodentodigital dysplasia. electrophysiology, confocal microscopy. The ENIGMA-II trial- Nitrous Myocardial infarction, cardiac oxide anaesthesia and cardiac death, randomized trial, morbidity after major surgery: a nitrous oxide randomized controlled trial. Modulation of nuclear calcium Nucleus, endothelin-1, cycling by ET-1 in heart cells. pharmacology, calcium heart. Role of gas6 in vascular biology. Gas6, gamma-carboxylation, thrombosis, endothelium. Principal Investigator Institute of Principal and Co-Investigator(s) Investigator Agharazii, Mohsen Centre hospitalier universitaire de Québec Allen, Bruce G. Montreal Heart Institute Baroudi, Ghayath Hôpital du Sacré- Coeur de Montréal Beattie, William S.; Health Devereaux, Philip J.; Network Choi, Peter T-L; Jacka, Michael J.; Badner, Neal H.; Yang, Homer Y.H.; Schricker, Thomas P.S.; Buckley, David Norman N. Bkaily, Ghassan Université de Sherbrooke Blostein, Mark D. Jewish General Hospital 25,000 49,000 I,II 20,000 39,500 I 20,000 20,000 I 20,000 39,500 II ,000 56,500 I 20,000 39,500 I Bonnet, Sébastien Université Laval Dehydroepiandrosterone Vascular remodeling , ,000 I reverses vascular remodeling diseases. diseases, apoptosis, k+ channels, PI3K, NFAT Bossé, Yohan; Université Laval Genetic susceptibility to calcific Aortic stenosis, candidate ,000 56,500 I,II Pibarot, Philippe; Mathieu, Patrick aortic valve stenosis. genes, genomics, microarray, genotyping. Bouchard, Luigi; Université de Epigenetic contribution to Metabolic syndrome, 26,000 26,000 I,IV Brisson, Diane; Gaudet, Daniel; Lamarche, Benoit; Montpetit, Alexandre; Mill, Jonathan Montréal HDL-cholesterol variability in cardiovascular disease. converging genomics, microarray. Boulay, Guylain Université de Sherbrooke Conséquence de la phosphorylation de TRPC6 dans les cellues musculaires lisses vasculaires. TRPC, signalisation, phosphorylation, clacium, muscle lisse, biologie moléculatire. 20,000 20,000 I Themes I: Basic Biomedical II: Clinical III: Health Services/Systems IV: Population Health 97

104 Heart and Stroke Foundation Research Report Principal Investigator Institute of Principal and Co-Investigator(s) Investigator Bouvier, Michel Université de Montréal Brissette, Louise Université du Québec à Montréal Cardinal, René Hôpital du Sacré- Coeur de Montréal Carrier, Marc; Ottawa Health Rodger, Marc A.; Research Institute Tao, Hardy H.; Ramsay, Timothy O.; Coyle, Douglas A.; Wells, Philip S.; Le Gal, Grégoire; Lee, Agnes Y.Y.; Lazo-Langner, Alejandro; Tagalakis, Vicky Project Keywords Term $ Cumulative Theme $ to Molecular basis of G proteincoupled receptor functional selectivity, adrenergic drugs, GPCR structure, signalling, selectivity. biosensors. AMP kinase and lipoprotein Lipoprotein, AMPK, metabolism. cholesterol, SR-BI, CD36. Intrinsic cardiac nervous system. Cardiac arrhythmias, multi-electrode mapping, ganglionated plexuses, autonomic nervous system, cardiac electrophysiology, intracellular recording, neurons. Screening for previously Venous thromboembolism, undiagnosed malignancy in randomized controlled patients with unprovoked trial, cancer, screening, venous thromboembolism:a comprehensive computed randomized controlled trial tomography using a comprehensive computed tomography of the abdomen/pelvis. Chahine, Mohamed Université de Laval Probing the intracellular pore of Nav1.5 sodium channel and its regulation by the beta1 subunit. Nav1.5, sodium channels, antiarrhythmic drugs, arrhythmias, structurefunction. Chan, John S. D. CHUM Hypertension and regulation Hypertension, of angiotensinogen gene angiotensinogen gene, expression in transgenic mice. heterogenous nuclear ribonucleoproteins, gene regulation, nephropathy, transgenic mice. Claing, Audrey Université de Elucidation of the role of ARF Endothelial cells, vascular Montréal proteins in the function of smooth muscle cells, endothelial and vascular smooth GTPases, migration, muscle cells. proliferation. Couet, Jacques; Hopital Laval: The dilated heart: insights Left ventricle, volume Arsenault, Marie Institut universitaire from an animal of left ventricle overload, hypertrophy, de cardiologie volume overload. exercise, life habits. et pneumologie de Québec Couture, Rejean Université de Kinin receptors in diabetes and Peptides, CNS, diabetes, Montréal hypertension. hypertension, phamacology. 25,000 49,000 I 20,000 39,500 I 25,000 49,000 I 20,000 39,500 II, III 25,000 49,000 I 25,000 49,000 I 25,000 49,000 I 20,000 20,000 I 20,000 39,500 I 98

105 Heart and Stroke Foundation Research Report Principal Investigator Institute of Principal and Co-Investigator(s) Investigator Eisenberg, Mark J.; Jewish General Filion, Kristian B.; Hospital Genest, Jacques; Lawrence, Joseph; Pilote, Louise; Poirier, Paul; Schiffrin, Ernesto L. Escher, Emanuel Université de Sherbrooke Fiset, Céline Université de Montréal Garcia, Damien; CHUM Pibarot, Philippe Genest, Jacques; Royal Victoria Krimbou, Larbi; Hospital Engert, James C. Guillemette, Université de Gaétan Sherbrooke Gutkowska, CHUM Jolanta; Jankowski, Marek Project Keywords Term $ Cumulative Theme $ to The efficacy of weight loss interventions: A systematic review and heirarchical bayesian meta-analysis. Weight loss, cardiovascular disease prevention, obesity, meta-analysis, clinical equipoise. Bases moléculaires de la Récepteur GPCR, fonction du récepteur AT1 de mécanismes postrécepteurs, l'angiotensine II. modélisation moléculaire, signalisation intracellulaire. Mechanisms underlying cardiac K+ channels, cardiac arrhythmia in transgenic models electrophysiology, transgenic of hypertrophy and heart failure. mouse, mouse heart, cardiac repolarization. Echocardiographic assessment Left ventricular function, heart of left ventricular function using failure, echocardiography, coupled wall-fluid dynamics animal experiments, image mapping. processing. Genetics of high density Genetics, high density lipoproteins. lipoproteins, DNA sequencing, WWOX gene. Étude des IP3Rs dans Endothélium, calcium, l'endothélium. mtor, calcineurine, inositol 1,4,5-triphosphate. The role of brain natriuretic Diabetes, heart, db / peptide and oxytocin in db mice, oxytocin, brain prevention of metabolic and natriuuretic peptide. cardiovascular complications in diabetes. 20,000 20,000 IV 25,000 49,000 I ,000 72,000 I 26,000 26,000 I,II 25,000 49,000 I,II,IV ,000 72,000 I 20,000 20,000 I,II,III,IV Hébert, Terence E. McGill Composition, ontogeny and Signalling, G proteins, ,000 72,000 I biosynthesis of specific GPCR signalling complexes. organization, heart failure, adrenergic receptors. Huot, Jacques Hôtel-Dieu de Role of stress-sensitive Oxidative stress, VEGF, ,000 72,000 I,II Québec pathways in regulating endothelial cell activation and functions. endothelial cells, signaling, angiogenesis. Hussain, Sabah Royal Victoria Roles of nox proteins in Angiogenesis, endothelial ,000 72,000 I N.A. Hospital angiopoietin/tie-2 signaling. cells, NAPHD oxidase, nox4, nox2, oxygen radicals. Jacquemet, Vincent Hôpital du Sacré- Coeur de Montréal A modeling approach to analyze the electrophysiological substrate of atrial fibrillation. Atrial fibrillation, electrophysiological substrate, fractionated electrogram, computer modeling, signal processing. 20,000 20,000 I Themes I: Basic Biomedical II: Clinical III: Health Services/Systems IV: Population Health 99

106 Heart and Stroke Foundation Research Report Principal Investigator and Co-Investigator(s) Institute of Principal Investigator Jacques, Danielle Université de Sherbrooke Jankowski, Marek; CHUM Hôtel-Dieu Gutkowska, Jolanta de Montréal Joanette, Yves; Institut universitaire Ska, Bernadette de gériatrie de Montréal Jones, Elizabeth McGill A.V. Project Keywords Term $ Cumulative Theme $ to Regulation of secretion of cardiac endocardial endothelial cell by neuropeptide Y. Endocardial endothelium, neuropeptide Y, confocal microscopy, nucleus, calcium, secretion. Cellular effect of oxytocin Oxytocin, myocardial during heart regeneration. infarction, heart regeneration, stem cells, differentiation. Understanding the Stroke, communication distinct clinical profiles of impairment, right communication impairments hemisphere, clincial subtypes, after a right-hemisphere stroke. brain imaging, cross-cultural comparison. Integratrion of signalling and Hemodynamics, neuropilin-1, mechanics by the endothelium; shear stress, gene expression, investigating the role of mechanotransduction. neuropilin-1. 20,000 20,000 I 20,000 20,000 I,II,III,IV 20,000 20,000 II 20,000 39,500 I Kiss, Robert S. McGill Understanding of regulated Cholesterol, intracellular 20,000 39,500 I intracelluar cholesterol movement and cell growth through interplay between LRP1 and its adapter proteins. trafficking, HDL, GULP, cell growth. Kriz, Jasna Centre hospitalier de l'université Laval The role of Galectin-3 in stroke. Stroke, MCAO, inflammation, reporter mice, biophotonic/ bioluminescence imaging. 20,000 20,000 I Langlois, Marie- France Université de Sherbrooke Study of the role of GRP1 in PPAR-gamma-mediated transcription and regulation of adipogenesis. Nuclear receptors, PPAR-gamma, GRP1, transcriptional regulation, adipogenesis. Larose, Eric; Institut universitaire Is vulnerable atherosclerosis a Atherosclerosis, metabolic Bertrand, Olivier F.; de cardiologie local or systemic phenomenon? risk, cerebrovascular- Poirier, Paul; et de pneumologie cardiovascular, interaction risk Pibarot, Philippe; de Québec stratification. Després, Jean- Pierre Lavoie, Julie L. CHUM Role of the tissue-specific Obesity, obesity-related renin-angiotensin system in hypertension, reninangiotension adipose tissue in obesity and system, adipose obesity-related hypertension. tissue ,000 56,500 I 26,000 26,000 I,II,IV ,000 56,500 I Ledoux, Jonathan Montreal Heart Regulation of CaMKII activity by Endothelium, CaMKII, 20,000 39,500 I Institute intracellular calcium pulsars in native endothelium. intracellular calcium, electrophysiology, hypertension. Lemieux, Simone; Dodin, Sylvie S.D. Université Laval Gender differences in response to the Mediterranean diet. Cardiovascular disease risk profile, Mediterranean diet, nutritional intervention, gender differences, diet adherence. 25,000 49,000 II 100

107 Heart and Stroke Foundation Research Report Principal Investigator Institute of Principal and Co-Investigator(s) Investigator Lerouge, Sophie; CHUM Soulez, Gilles Ly, Hung Q. Montreal Heart Institute Mandato, Craig A.; McGill Greenwood, Michael T. Marelli, Ariane J.; Royal Victoria Pilote, Louise; Hospital Therrien, Judith; Mackie, Andrew S.; Khairy, Paul; Abrahamowicz, Michal Marleau, Sylvie; Université de Ong, Huy; Montréal Carpentier, André C. Maurice, Roch Listz Hôpital Nôtre- Dame Mukaddam- CHUM Daher, Suhayla; Gutkowska, Jolanta Project Keywords Term $ Cumulative Theme $ to Chitosan thermogels to combine embolization and cell therapy for the prevention of Biomaterials, embolisation, aneurysms, chitosan, cell seeding. endoleaks after endovascular aneurysm repair. Homing and engraftment of Stem cells, heart, homing, stem cells: implications for engraftment, translational cardiac repair and regeneration research. in the setting of ischemic heart diseases. Analysis of novel anti-apoptotic Anti-apoptosis, cultured genes in cardiomyocytes. cardiomyocytes, HL-1 cells, bax suppressors, apoptosis. A population-based analysis of Adults, congenital, heart changing survival of patients defects, epidemiology, with congenital heart disease. population study. Cardioprotective effects of Azapeptide, remodeling, novel azapeptide analogs. myocardial ischemiareperfusion, CD36, micromri. Non-invasive vascular microelastography Hypertension, functional and functional genomics, small animal genomics: investigating imaging, ultrasound, tissue hypertension with rat models. mechanical properties. Effects of sympathetic inhibition Apoptosis, beta adrenergic in cardiac pathologies. blockers, cardiac pathology, imidazoline receptors, in vivo, in vitro. 20,000 20,000 I ,000 56,500 I 20,000 20,000 I ,000 56,500 III,IV 20,000 20,000 I 25,000 49,000 I,II,IV ,000 56,500 I Nantel, André McGill A systems biology approach to Apoptosis, systems biology, 20,000 20,000 I the study of apoptosis in heart cells. signal transduction, phosphorylation, gene expression. Nattel, Stanley Montreal Heart Factors influencing the Sudden death, ventricular 26,000 26,000 I Institute interaction of antiarrhythmic drugs with cardiac tissue. arrhythmias, remodeling, antiarrhythmic therapy, repolarization. Noiseux, Nicolas; Perrault, Louis P. CHUM Novel application for stem cell therapy: intracoronary injection of mesenchymal stem cell conditioned medium improves protection and functional recovery of infarcted myocardium. Cellular therapy, stem cell, myocardial infarct, cardiac function, cardioprotection. 20,000 39,500 I Themes I: Basic Biomedical II: Clinical III: Health Services/Systems IV: Population Health 101

108 Heart and Stroke Foundation Research Report Project Keywords Term $ Cumulative Theme $ to Neonatal oxygen exposure Hypertension, programming, leads to premature aging of the oxidative stress, kidney, vascular system and the kidneys: aging. role in adult hypertension. Neurogenic substrates of atrial Autonomic nervous fibrillation. system, atrial fibrillation, electrophysiologic cardiac mapping, coronary artery bypass grafting, extracellular neuronal recording. Molecular studies of the Calcium, electrophysiology, cardiovascular L-type Ca gating, structure, molecular channel in health and in biology. disease. Genesis Praxy: Gender and sex Cardiovascular disease, determinants of cardiovascular gender and sex differences, disease from bench to beyond premature acute coronary in premature acute coronary syndrome, risk factors, syndrome. determinants of health Principal Investigator Institute of Principal and Co-Investigator(s) Investigator Nuyt, Anne Sainte-Justine Monique; Lavoie, Hospital Jean-Claude; Beauséjour, Christian Pagé, Pierre Hôpital du Sacré- Coeur de Montréal Parent, Lucie Université de Montréal Pilote, Louise; Université McGill Karp, Igor; Bacon, Simon L.; Chalifour, Lorraine E.; Cox, Jafna L.; Dasgupta, Kaberi; Daskalopoulou, Styliani-Stella ; Eisenberg, Mark J.; Engert, James C.; Ghali, William A.; Hamet, Pavel; Humphries, Karin H.; Khan, Nadia A.; Lavoie, Kim L.; Norris, Colleen M.; Rabi, Doreen M.; Stark, Ken D.; Tagalakis, Vicky; Tremblay, André; Tu, Jack V. 20,000 20,000 I,II,III,IV 25,000 25,000 I ,000 72,000 I ,000 56,500 II, III, IV Powell, William S. McGill Eicosanoids and leukocyte and Lipid mediators, oxidative 25,000 49,000 I endothelial cell function. stress, neutrophils, endothelial cells, pyridine nucleotides. Raymond, Jean; CHUM Radiofrequency endothelial Brain aneurysm, animal 25,000 49,000 I Coutu, Benoit; Savard, Pierre ablation to improve results of endovascular treatment of intracranial aneurysms. models, endovascular treatment, endothelial denudation, radiofrequency ablation. Richard, Darren E. Université Laval Role of HIF-1 induction in the vasculature. HIF, hypoxia, smooth muscle, angiotensin, cell signaling ,000 72,000 I 102

109 Heart and Stroke Foundation Research Report Principal Investigator Institute of Principal Project Keywords Term $ Cumulative Theme and Co-Investigator(s) Investigator $ to Rosenberg, Ellen E.; McGill Is control of cardiovascular Hypertension, hperlipidemia, 26,000 26,000 II,III Battaglini, Alex A.B.; Bartlett- Esquilant, Gillian; Dawes, Martin G.; Dasgupta, Kaberi; Grad, Roland M.; Leanza, Yvan; Lussier, Marie- Therese; Mayo, Nancy; Pavilanis, Alan V.; Vissandjee, Bilkis disease risk factors better in immigrants not proficient in English or French when there is a professional interpreter? Pilot project. diabetes, interpreters, migrants. Rouleau, Guy A. CHUM Homozygosity mapping Intracranial aneurysm, 25,000 25,000 I and linkage study in French Canadian families from Québec City and in Inuits from Northern Québec, aggregatred with brain aneurysm. genetics, variant detection, genome scan, gene mapping. Rousseau, Guy Hôpital du Sacré- Effect of different omega-3/6 Myocardial infarction, 20,000 20,000 I,IV Coeur de Montréal ratios in myocardial infarction and post-mi depression. omega-3, depression, reperfusion, cardioprotection. Sauvé, Remy Université de Molecular studies of the calcium ,000 72,000 I Montréal activated KCa3.1 channel expressed in endothelial cells. Servant, Marc Université de Understanding the activation Inflammation, angiotensin 20,000 20,000 I Montréal and the roles of the IKK complex-nf-κb signaling cascade in the inflammatory and hypertrophic actions of angiotensin II in vitro and in vivo. II, NFkB, phosphorylation, polyubiquitination. Sévigny, Jean Université Laval Implication des nucléotides Tonus vasculaire, 20,000 20,000 I dans la modulation du tonus artériel. ectonucleotidase/ntpdase1/ CD39, ATP/ADP/UTP/UDP, récepteurs P2Y, nucléotides extracellulaires. Shrier, Alvin; McGill Potassium channel block and HERG channel block, 25,000 49,000 I Glass, Leon M. cardiac arrhythmias in tissue culture. arrhythmias, tissue culture, mathematical modelling, optical mapping. Simard, Chantale; Université Laval The role of diabetes in Atrial fibrillation, KCNA5, 20,000 39,500 I Drolet, Benoit; Daleau, Pascal triggering and perpetuating atrial fibrillation. connexins 40 and 43, diabetes, cardiac electrophysiology. Sirois, Martin G. Montreal Heart Institute Agonistic activities of angiopoietins on neutrophils. Angiopoietins, Tie2 receptor, neutrophils, cell signaling, inflammation. 20,000 39,500 I Themes I: Basic Biomedical II: Clinical III: Health Services/Systems IV: Population Health 103

110 Heart and Stroke Foundation Research Report Thiel, Alexander; Paquette, Caroline; Fung, Joyce Jewish General Hospital Improving post-stroke recovery by combining non-invasive brain stimulation with rehabilitation. Stroke, brain stimulation, neuroimaging, rehabilitation, robotics. Thorin, Eric; Montreal Heart Risk factors for cardiovascular Cerebrovascular dysfunction, Ferland, Guylaine; Institute diseases and cerebrovascular aging, dyslipidemia, cerebral Hamel, Edith function. blood flow, cognitive impairment. Turgeon, Jacques CHUM The expression of drug influx/ Electrophysiology, efflux transporters in the heart: drug-induced long a new paradigm for intersubject QT-syndrome, transporters, variability in cardiac drug proarrhythmias, drug actions. interactions. Vidal, Silvia M. McGill Molecular genetics of host Antiviral immunity, complex susceptibility to cardiovirulent trait analysis, coxsakievirus coxsakievirus infection. (Enterovirus) infection, models of infection, mouse genetics. Principal Investigator Institute of Principal Project Keywords Term $ Cumulative Theme and Co-Investigator(s) Investigator $ to St-Amand, Jonny Université Laval Characterization of two novel Coronary artery diseases, ,000 56,500 I signals regulating dietary fat intake. obesity, dietary fat intake, gene discoveries, protein injection. Stochaj, Ursula McGill Protein trafficking in stressed cells. Oxidative stress, 5'-AMPactivated kinase (AMPK), nuclear transport, ischemia/ reperfusion ,000 56,500 I 26,000 26,000 I,II 25,000 49,000 I ,000 72,000 I ,000 56,500 I,II,III,IV Wang, Zhiguo Montreal Heart A signature pattern of stressresponsive mirna, gene expression, ,000 72,000 I Institute micrornas that can induce cellular injuries during myocardial infarction. myocardial infarction, arrhythmias, cell death. Wu, Jiangping CHUM Immune regulation in heart Drak2, transplantation, ,000 72,000 I transplantation. chronic rejection, kinase. Zhang, Shao-Ling CHUM Hôtel-Dieu de Montréal Perinatal programming of hypertension and angiotensin converting enzyme-2. Hypertension, perinatal programming, angiotensin converting enzyme-2, transgenic mice, maternal diabetes. 20,000 20,000 I 104

111 Heart and Stroke Foundation Research Report New Brunswick Principal Investigator and Co-Investigator(s) Currie, R. William; Li, Gefeng Howlett, Susan E. Surette, Marc E. Lee, Timothy D.G.; Hirsch, Gregory M.; Ostry, Avrum J. Waisman, David M. Institute of Principal Investigator Dalhousie Dalhousie Université de Moncton Dalhousie Dalhousie Project Keywords Term $ Cumulative Theme $ to Heat shock proteins, inflammation and cardiovascular protection. Heat shock proteins, blood vessels, inflammation, heart, brain. The impact of age on cardiac Cardiac contraction, calcium contractile function. homeostasis, aging, sex differences, estrogen. Control of 5-lipoxygenase Inflammation, leukotrienes, expression in human leukocytes. leukocytes, arachidonic acid, gene expression. Etiology of allograft vasculopathy Chronic rejection, after cardiac transplantation: role allograft vasculopathy, of pre-existing vascular disease. transplantation. Defining the physiological S100a10, annexin, function of S100A10 with the fibrinolysis, plasminogen, S100A10-knockout mouse. plasmin. 60, ,000 I 58,055 58,055 I 60, ,000 I , ,186 I , ,000 I,II Nova Scotia Principal Investigator and Co-Investigator(s) Baskett, Roger J.F.; Herman, Christine R.; Legare, Jean- Francois Cameron, Jill I.; Naglie, Gary; Gignac, Monique; Hoch, Jeffrey; Cheung, Angela; Juiibregts, Maria; Silver, Frank; Bayley, Mark; Finestone Hillel; Warner, Grace; Phillips, Steve; Green, Terri; Weir, Nic; Suddes, Michael Dupré, Denis J. Hirsch, Gregory M.; Lee, Timothy D.G.; Nashan, Bjorn P.A. Institute of Principal Investigator Queen Elizabeth II Health Sciences Centre Toronto Dalhousie Dalhousie Project Keywords Term $ Cumulative Theme $ to Reducing post-operative major Cardiac surgery, morbidity, adverse cardiac events in cardiac mortality, practice change. surgery: towards a prospective intervention. Optimizing stroke family caregiver Stroke, family care-giving, support across the care continuum support, intervention, by improving the timing of randomized controlled trial. intervention delivery. Specificity of signaling of beta2- G protein coupled receptor, adrenergic AT1 angiotensin protein-protein interaction, homo and heterodimeric receptor BRET, trafficking, chaperone. complexes. Role of antibody in allograft B cells, allograft vasculopathy. vasculopathy, transplantation, antibody, media. 42,025 42,025 II,IV 24,390 64,940 II, III, IV , ,000 I 47,000 94,000 I Themes I: Basic Biomedical II: Clinical III: Health Services/Systems IV: Population Health 105

112 Heart and Stroke Foundation Research Report Principal Investigator and Co-Investigator(s) McMaster, Christopher R. Pasumarthi, Kishore Babu S. Pavlov, Evgeny Pilote, Louise; Karp, Igor; Bacon, Simon L.; Chalifour, Lorraine E.; Cox, Jafna L.; Dasgupta, Kaberi; Daskalopoulou, Styliani-Stella; Eisenberg, Mark J.; Engert, James C.; Ghali, William A.; Hamet, Pavel; Humphries, Karin H.; Khan, Nadia A.; Lavoie, Kim L.; Norris, Colleen M.; Rabi, Doreen M.; Stark, Ken D.; Tagalakis, Vicky; Tremblay, André; Tu, Jack V. Ridgway, Neale D. Robertson, George S. Rose, Robert A. Institute of Principal Investigator Dalhousie Dalhousie Dalhousie McGill Dalhousie Dalhousie Dalhousie Project Keywords Term $ Cumulative Theme $ to Inherited infantile x-linked cardiomyopathies: understanding the molecular function of tafazzin. Phospholipid, cardiolipin, metabolism, mitochondria, heart disease. Characterization of proteins Cardiomyocyte cell cycle, regulating cardiomyocyte cell cycle. myocardial repair, gene transfer, transgenic mice, protein-protein interactions. Investigation of the molecular Mitochondria, composition and mechanisms of permeability transition induction of the mitochondrial pore, polyphosphate, permeability transition pore. polyhydroxybutyrate. Genesis praxy: Gender and sex Cardiovascular disease, determinants of cardiovascular gender and sex differences, disease from bench to beyond premature acute coronary in premature acute coronary syndrome, risk factors, syndrome. determinants of health. Role of oxysterol binding proteinrelated Cholesterol, oxysterol, protein 4 (ORP4) in cellular OSBP, sterol transport, cholesterol transport. sphingolipids. Enhancement of cognitive Erythropoietins, spatial function after ischemic brain memory, stroke, functional injury: assessment of the role of recovery. erythropoietin. The role of the natriuretic peptide Natriuretic peptide, C receptor (NPR-C) in heart rate sinoatrial node, heart regulation and sinoatrial node rate, arrhythmia, function. electrophysiology , ,000 I 50,000 50,000 I 47,000 47,000 I , ,000 II, III, IV 48,850 97,700 I , ,970 I,II 44,465 88,930 I,II 106

113 Heart and Stroke Foundation Research Report Newfoundland and Labrador Principal Investigator and Co-Investigator(s) Morshead, Cindi M.; Shoichet, Molly S.; Corbett, Dale R. Institute of Principal Investigator Toronto Project Keywords Term $ Cumulative $ to Theme The development of drug and Drug and cell delivery; , ,000 I cell delivery systems for use in cell neural stem cells; based therapies to treat stroke. transplantation; endogenous stimulation; rehabilitation Themes I: Basic Biomedical II: Clinical III: Health Services/Systems IV: Population Health 107

114 Heart and Stroke Foundation Research Report 108

115 APPENDIX D RESEARCH CHAIRS AND PROFESSORSHIPS Photo: Dr. Ken Butcher ( Alberta) holds the Heart and Stroke Foundation of Alberta, NWT & Nunavut Professorship in Stroke Research.

116 Heart and Stroke Foundation Research Report Research Chairs and Professorships Research Chairs Title Type Foundation $ Value Dr. Lear Scott, Pfizer/ Heart and Stroke Foundation of BC Cardiovascular HSFBCY 150,000 St. Paul's Hospital/ Simon Fraser & Yukon Chair in Cardiovascular Prevention Research Prevention Research Dr. Yu Tian Wang, Heart and Stroke Foundation of BC & Yukon Stroke HSFBCY 0 British Columbia Chair in Stroke Research Dr. Harald Becher, Heart and Stroke Foundation of Alberta, NWT & Cardiology HSFA 139,632 Alberta Nunavut Chair in Cardiovascular Research Dr. Henry Duff, Heart and Stroke Foundation of Alberta, NWT & Cardiology HSFA 82,505 Calgary Nunavut Chair in Cardiovascular Research Dr. Andrew Demchuk, Heart and Stroke Foundation of Alberta, NWT & Stroke HSFA 37,588 Calgary Nunavut Chair in Stroke Research Dr. Sonia Anand, Heart and Stroke Foundation of Ontario / Population Health HSFO 0* McMaster Michael G. DeGroote Chair in Population Health Research Dr. Heather Arthur, Heart and Stroke Foundation of Ontario / Cardiac Nursing HSFO 35,890 McMaster Michael G. DeGroote Chair in Cardiovascular Nursing Dr. Fred Keeley, Heart and Stroke Foundation of Ontario / Robert Cardiology HSFO 137,863 Hospital for Sick Children M. Freedom Chair in Cardiovascular Science at the Hospital for Sick Children Dr. Jeffrey Weitz, Heart and Stroke Foundation of Ontario / J. Cardiology HSFO 0* McMaster Fraser Mustard Chair in Cardiovascular Research at McMaster Dr. Salim Yusuf, Heart and Stroke Foundation of Ontario/ Marion Cardiology HSFO 0* McMaster W. Burke Chair in Cardiovascular Disease at McMaster Dr. Geoffrey Pickering, Heart and Stroke Foundation of Ontario/ Cardiology HSFO 31,919 Robarts Research Institute Barnett-Ivey Chair at the Robarts Research Institute Dr. Shaun Goodman, Heart and Stroke Foundation of Ontario Polo for Cardiology HSFO 0* Toronto Heart Chair at the Toronto Dr. Jafna Cox, Heart and Stroke Foundation Endowed Chair in Cardiology HSFNS 60,035 Dalhousie Univerisity Cardiovascular Outcomes Professorships Title Type Foundation $ Value Dr. Philip Teal, The Sauder Family/ Heart and Stroke Foundation Clinical Stroke HSFBCY 0 British Columbia of BC & Yukon Professorship in Clinical Stroke Research Dr. Ken Butcher, Alberta Heart and Stroke Foundation of Alberta, NWT & Nunavut Professorship in Stroke Research Stroke HSFA 60,000 Typically, Research Chairs and Professorships are funded via an endowment from the provincial Foundations listed as well as endowments from other sources. *Reduced funding for Chairs for this year is linked to the institution s long-term strategy to maintain endowed fund market values above the original donated value. HSF contributions to the chairs and professorships had already been met, so no funds were awarded for the 2010/ year. 110

117 APPENDIX E PROVINCIAL PERSONNEL AWARDS Photo: Dr. Majid Heidari-Mohajerani ( British Columbia) was the recipient in for the HSFC Henry J.M. Barnett Scholarship award.

118 Heart and Stroke Foundation Research Report Saskatchewan Master s Studentship Award Award: $17,500* Awardee Supervisor Institute Poloni, Luca* Cayabyab, Frank Saskatchewan Undergraduate Studentship Award Award: $4,500 Awardee Supervisor Institute Barbour-Tuck, Sherar, Lauren Saskatchewan Erin Tarasoff, Lauren Chad, Karen Saskatchewan Manitoba Sanofi Aventis / Heart and Stroke Foundation of Manitoba Award in Cardiology Award: $10,000 Awardee Nguyen, Thang Master s Student Award Award: $1,000 Institute Manitoba Awardee Supervisor Institute Ganguly, Riya Pierce, Grant St. Boniface G.H. Research Centre Wong, Andy Xiong, Cherry Campanucci, Veronica Cayabyab, Francisco S. Saskatchewan Saskatchewan B.Sc. in Medicine Studentship Award: $5,000 Awardee Supervisor Institute Fultz, Benjamin Zhanel, George Manitoba Leibl, Marli Chudley, Albert Manitoba McNaughton, Leslie Kardami, Elissavet Manitoba Red River College (RRC) Summer Studentship Award Award: $4,000 Awardee Supervisor Institute Cox, Greg Sithoo, Brian Red River College Gabutero, Sophie Sithoo, Brian Red River College Rutherford, Jaclyn Sithoo, Brian Red River College Wong, Simon Sithoo, Brian Red River College * Saskatchewan has supported the second year of this award in the amount of $17,

119 Heart and Stroke Foundation Research Report Ontario Distinguished Scientist Awards Awardee Institute Award Description Term $ Total $ Tu, Jack V. Institute for Clinical Evaluative Sciences Dr. Lowell Langille Tribute Award Spencer, McMaster Fortino's Distinguished Frederick A. Scientist Award Parker, John D. Toronto Sifton Distinguished Scientist Award Supplementary funding for highest rated Career Investigator Award recipient to use to support trainee mentoring activities Supplementary funding for five years for the highest rated Career Investigator at McMaster. Supplementary funding for five years for the highest rated Career Investigator at the Toronto ,000 10, ,000 50, ,000 40,000 Career Investigator Awards Awardee Institute Project Term $ Total $ Alter, David A. Institute for Clinical Evaluative Sciences Cardiovascular treatment & outcomes disparities among high-risk populations Austin, Peter C. Institute for Clinical Evaluative Statistical methods for cardiovascular research Sciences Austin, Richard McMaster Role of endoplasmic reticulum stress in atherothrombotic C. disease. Backx, Peter H. Toronto Studies into molecular mechanisms of cardiovascular disease. Beanlands, Ottawa Heart Institute Metabolism, energetics and neurohormonal signaling and Rob S. B. their response to therapy in dysfunctional myocardium. Bendeck, McMaster Cell adhesion signaling in the progression and complications Michelle P. of atherosclerosis Chidiac, Peter Western Ontario Impact of RGS proteins on cardiovascular function Crowther, Mark A. McMaster Reducing cardiovascular disease by improving our use of antithrombotic agents Cybulsky, Health Network Initiation of atherosclerosis: mechanisms and cell biology Myron I. Drangova, Robarts Research Institute Cardiac imaging for therapy guidance and pre-clinical Maria research studies. Feng, Western Ontario Mechanisms of heart failure. Qingping 2015 Ferguson, Robarts Research Institute Molecular regulation of G protein-coupled receptor signal Stephen S.G. transduction, desensitization and resensitization. Funk, Colin D. Queen's Lipoxygenase and cyclooxygenase pathways in cardiovascular disease. Hayward, McMaster Studies of novel platelet secretory proteins. Catherine P. Husain, Toronto Molecular studies of cardiac and vascular disease. Mansoor , ,750 87, ,750 87, ,750 87, ,875 87, ,750 83, ,000 87, ,750 87, ,750 87, ,750 87, ,750 83, ,000 87, ,750 87, ,750 83, ,500 87, ,750 Themes I: Basic Biomedical II: Clinical III: Health Services/Systems IV: Population Health 113

120 Heart and Stroke Foundation Research Report Awardee Institute Project Term $ Total $ Kearon, Clive McMaster Optimizing treatment and diagnosis of venous thromboembolism Koschinsky, Windsor Mechanisms of atherothrombosis: analysis of lipoprotein and Marlys L. fibrinolytic risk factors. Krahn, Andrew Western Ontario Inherited arrhythmias: clinical and genetic assessment of D. primary electrical disease. Lewis, Gary F. Health Network Determining the mechanisms of the dyslipidemia of insulin resistant states and Type 2 diabetes. Li, Ren-Ke Health Network Restoration of cardiac function: cellular regeneration and matrix reconstruction. Marsden, Philip Toronto The human nitric oxide synthase genes: relevance to disease A. Maurice, Queen's PDEs in blood vessels Donald H. Park, David S. Ottawa Pathways which regulate neuronal death Parker, John D. Mount Sinai Hospital Clinical studies concerning nitrate pharmacology and autonomic physiology in congestive heart failure. Pickering, J. Geoffrey Rodger, Marc A. Spencer, Frederick A. Steinman, David A. Tsushima, Robert G. Tu, Jack V. Yang, Burton B. London Health Sciences Centre Role of smooth muscle cells in vascular disease Ottawa Hospital Research Institute Thrombophilia and placenta mediated pregnancy complications. McMaster Clinical epidemiology and management of cardiovascular and venous thromboembolic disease. Toronto Hemodynamic factors in vascular disease: from bench to bedside York SNARE protein regulation of cardiac ion channels and ANF secretion Institute for Clinical Evaluative Sciences Improving the quality of cardiovascular care in Canada Sunnybrook and Women's College Roles of versican in mediating leukocyte and endothelial cell Health Sciences Centre activities. 87, ,750 87, ,750 87, ,750 43, ,875 87, ,750 43, ,875 87, ,750 87, ,750 87, ,750 43, ,875 87, ,750 87, ,750 87, ,750 87, ,750 83, ,000 87, ,

121 Heart and Stroke Foundation Research Report Clinician Scientist Awards Awardee Institute Project Term $ Total $ Connelly, Kim A. St. Michael's Hospital Role of TGFb acetylation in the pathogenesis of diabetic cardiomyopathy. Davis, Darryl R. Ottawa Heart Institute Mechanism of therapy: cardiac stem cells in myocardial repair. Dick, Sunnybrook Health Science Centre Endothelial progenitor cell modification to improve left Alexander J. ventricular function post myocardial infarction. Dos Santos, St. Michael's Hospital The Role of PGC1a in sepsis-induced myocardial Claudia C. depression. Fowler, Robert Sunnybrook Health Science Centre Prospective economic analysis in the prophylaxis for A. thromboembolism in critical care trial. Gladstone, Sunnybrook Health Science Centre Improving the detection and treatment of atrial fibrillation David J. following transient ischemic attack and stroke. Gollob, Ottawa Heart Institute Insight into the mechanisms of atrial fibrillation. Michael H. Leong-Poi, St. Michael's Hospital Ultrasound-targeted gene and cell-based strategies for Howard M. therapeutic angiogenesis. Rocca, Antonio Toronto Mediation of flow-induced arterial remodelling Salbach, Nancy Toronto Building physiotherapists' capacity to implement evidencebased M. stroke rehabilitation. Saposnik, St. Michael's Hospital Premature Stroke Associated with Recency of Immigration Gustavo to Ontario (PRESARIO). White, James Robarts Research Institute Myocardial scar imaging in heart failure: prediction of risk A. and therapeutic response. 64, ,000 64, ,000 70, ,750 64, ,000 70, ,750 70, ,750 70, ,750 70, ,750 64, ,000 64, ,000 64, ,000 64, ,000 Health Services/Population Health Research Post-Doctoral Research Fellowship Awards Awardee Supervisor Institute Project Term $ Total $ Mark, Amy E. Reid, Robert Ottawa Heart Institute Intervention for dietary behaviour change among individuals at risk for CHD. 59, ,500 Rac, Valeria E. Morrison, Laurie J. Toronto Prehospital evaluation and economic analysis of different coronary syndrome treatment strategies - PREDICT. 59, ,500 Syme, Catriona A. McCorkindale, Brian Toronto Determinants of cardiovascular and metabolic risk in overweight children and adolescents. 59, ,500 Health Services/Population Health Research Doctoral Research Award Awardee Supervisor Institute Project Term $ Total $ Kelley, Beverley Edwards, Nancy C. Ottawa Navigating community care post-stroke: an examination of older adults' experiences. 31,000 93,000 Themes I: Basic Biomedical II: Clinical III: Health Services/Systems IV: Population Health 115

122 Heart and Stroke Foundation Research Report Health Services/Population Health Research Master s Studentship Awards Awardee Supervisor Institute Project Term $ Total $ McPherson, Mark A. Aronson, Kristan J. Queen's Physical activity as a determinant of melatonin levels in rotating shift nurses. 18,500 37,000 Mecredy, Graham C. Janssen, Ian Queen's Built environments as determinants of cardioprotective behaviours in Canadian adolescents. 18,500 37,000 Master s Studentship Awards Awardee Supervisor Institute Project Term $ Total $ Andrusiak, Matthew G. Slack, Ruth Ottawa The role of prb in the regulation of neural stem cell fate. Assini, Julia Huff, Murray W. Robarts Research Prevention of dyslipidemia and atherosclerosis by Institute the citrus flaveonoid, nobiletin. Beca, Bogdan Simmins, Craig A. Toronto High-throughput screening of heart valve tissue Mihai engineering systems. Gates, Allison Tsuji, Leonard Waterloo Assessment of food intake and physical activity in Cree school children. Gates, Michelle Hanning, Rhona Waterloo Assessment of the Cree children's food intake using an innovative web-based survey. Giordano, Celine Ruel, Marc Ottawa Functional comparison of circulating progenitor cell subpopulations for cell-based angiogenesis. Law, Sai Fai Bosco Musson, David McMaster Improving effectiveness of cardiac resuscitation through high fidelity simulation and team training. Safarpour, Park, David Ottawa The potential role of Parkinson's disease gene Farzaneh F.S. PINK1 in stroke-induced cellular damage. Sofrenovic, Tanja Suuronen, Erik Ottawa Enhanced matrix for recruitment of circulating progenitor cells to the heart. Syrett, Andrew J. Bennett, Steffany Ottawa Bioactive glycerophospholipids and their role in modulating neuronal vulnerability following ischemia. Veerman, Kaley J. Werstuck, Geoff McMaster Investigating the role of the vasa vasorum in the development of diabetic atherosclerosis. 18,500 37,000 18,500 37,000 18,500 37,000 18,500 37,000 18,500 37,000 18,500 37,000 18,500 37,000 18,500 37,000 18,500 37,000 18,500 37,000 18,500 37,

123 Heart and Stroke Foundation Research Report Medical Student Awards Award: $4,000 or $6,000 Awardee Supervisor Institute Ahuja, Christopher Macdonald, R. Queen's Loch Anderson, Kathleen Maar, Marion Laurentian, Anselm, Daniel Beanlands, Rob Queen's Chari, Madhu Grosse- Toronto Wortmann, Lars Cooper, Joel St. Lawrence, Keith Western Ontario DeRita, Omar Hackam, Daniel Western Ontario Deshwar, Ashish Scott, Ian Toronto Jakubovic, Baruch Wald, Ron Toronto Lim Fat, Mary Jane Lum, Cheemun Ottawa MacIntosh, Sheila Chaudhuri, Bob Laurentian, Patel, Neeraj Hegele, Robert Western Ontario Piche, Matthew Tai, T.C. Laurentian, Russo, Juan Jose Jolly, Sanjit McMaster Shukla, Tushar Beanlands, Rob Ottawa Simard, Trevor O'Brien, Edward Ottawa Yates, William Tai, T.C. Laurentian, Yazdan-Ashoori, Payam Baranchuk, Adrian Queen's Themes I: Basic Biomedical II: Clinical III: Health Services/Systems IV: Population Health 117

124 Heart and Stroke Foundation Research Report Newfoundland and Labrador The Heart and Stroke Foundation Graduate Scholarship Award: $1,000 Awardee Supervisor(s) Institute Project Li, Shou Xie, Yagan and Han, Fei-Yu Memorial Vascular disease in China, including myocardial infarction and stroke The Keith Griffiths Memorial Heart and Stroke Foundation Graduate Scholarship Award: $1,000 Awardee Supervisor Institute Project Belanger-Willoughby, Natasha Hirasawa, Michiru Memorial Thermosensing by hypothalmic neurons The Heart and Stroke Foundation of Newfoundland and Labrador Nursing Award in Stroke Award: $1,000 Awardee Supervisor Institute Colbourne, Gina Manuel, April Memorial The Heart and Stroke Foundation of Newfoundland and Labrador Nursing Award in Cardiovascular Health Award: $1,000 Awardee Supervisor Institute Barnes, Catherine Manuel, April Memorial 118

125 APPENDIX F OTHER PROVINCIAL INITIATIVES Photo: Dr. Kishore Babu S. Pasumarthi (Dalhousie ) was the recipient in of a Grant-in-Aid and Dr. Gregory Ferrier Award from the Heart and Stroke Foundation of Nova Scotia.

126 Heart and Stroke Foundation Research Report Ontario Program Grants Principal Investigator Austin, Richard C. Beanlands, Rob S. B. Huff, Murray W. Institute Project Co-Investigator(s) Term $ Total $ McMaster Identification and characterization of Janssen, Luke J.; Nurse, Colin A.; novel and therapeutic strategies that Trigatti, Bernardo L.; Gross, Peter L.; decrease atherothrombotic disease. Igdoura, Suleiman A. Ottawa Elucidation of metabolic and cellular Heart Institute function alterations in dysfunctional myocardium and their response to therapy. Robarts Research Cellular programs and responses in Institute atherosclerosis. de Kemp, Robert A.; Ruel, Marc Andre; DaSilva, Jean N.; Harper, Mary-Ellen; Gollob, Michael H.; Suuronen, Erik J. Ferguson, Stephen G.; Hegele, Robert A.; Pickering, J. Geoffrey Social Determinants of Hypertension Principal Investigator Wade, Terrance J ,000 1,250, ,989 1,249, ,000 1,250,000 Institute Project Co-Investigator(s) Term $ Total $ Brock Social determinants of child Shoemaker, J. Kevin; O'Leary, Deborah , ,357 hypertension. D.; Klentrou, Panagiota; LeBlanc, Paul J.; Hay, John A.; Cairney, John; Liu, Jian; Roy, Brian D.; Hood, Colleen; Zinga, Dawn Pilot Project Grant Principal Investigator Fodor, George J. Kuk, Jennifer L. Tu, Jack V. Institute Project Co-Investigator(s) Term $ Total $ Ottawa A comparison of cardiovascular risk Ruzicka, Marcel; Byrapaneni, Ramesh ,887 49,887 Heart Institute between Chinese and South Asian Babu; Wang, Zengwu Canadians, and residents in China and India. York Project RADICAL: Race/ethnicity Ritvo, Paul G.; Lam, Yuk-Miu; Ardern, ,000 50,000 and the perception of diabetes and Chris I.; Hamadeh, Mazen; Jamnik, cardiovascular disease risk factors in Veronica K.; Salmon, Art; Wharton, the context of Canada's Lifestyle and Sean Obesity Guidelines. Institute for Clinical Effects of immigration and Chiu, Maria ,000 50,000 Evaluative Sciences acculturation on cardiovascular risk profiles of Ontario's four major ethnic groups. Congenital Heart Disease in Adults in the Province of Ontario s Operating Grant Principal Investigator Lee, Douglas Institute Project Co-Investigator(s) Term $ Total $ Toronto Congenital heart disease in adults in Mah, May Ling; Silversides, Candice 99,668 99,668 the province of Ontario. 120

127 Heart and Stroke Foundation Research Report Canadian Partnership Against Cancer CLASP Operating Grant Principal Investigator Larsen, Craig Institute Project Co-Investigator(s) Term $ Total $ Chronic Disease Collaborative action on childhood Naylor, Patti-Jean; Warshawski,Tom; Prevention Alliance obesity. Batal, Malek; Forget Marin, Francine; Pellerin, Suzie; De Roose, Elsie 100, ,000 Heart and Stroke Foundation Centre for Stroke Recovery Dr. Dale Corbett, Scientific Director and CEO Dr. Antoine Hakim, Site Director Ottawa Hospital Research Institue Dr. Brian Levine, Site Director Baycrest, Rotman Research Institute Dr. Sandra Black, Site Director Sunnybrook Health Sciences Centre HSFO contribution - $4,132,000 Heart and Stroke/Richard Lewar Centre of Excellence in Cardiovascular Research Director: Dr. Mansoor Husain, Toronto A portion of the Heart and Stroke Foundation, Ontario s original $6 million contribution continued to support the HSF Lewar Centre in. Québec Heart and Stroke Foundation of Québec Awards for Excellence in Research Awards for excellence highlighting the outstanding contribution of researchers. These awards enhanced the grants allocated to these researchers in : The 4th International Conference on Preventive Cardiology Award Dr. Eric Larose (Institut universitaire de cardiologie et de pneumologie de Québec) $20,000 The Desjardins Financial Security Award Dr. Anne Monique Nuyt (CHU Sainte-Justine) $10,000 The John J. Day Award Dr. Ellen E. Rosenberg (McGill ) $10,000 The Jonathan-Ballon Award Dr. Luigi Bouchard and Dr. Diane Brisson (Université de Montréal) $10,000 The Pfizer Canada Award Dr. Guy Rousseau (Hôpital du Sacré-Cœur de Montréal) $10,000 The RBC Royal Bank Award Dr. Alexander Thiel (Jewish General Hospital) $10,000 Themes I: Basic Biomedical II: Clinical III: Health Services/Systems IV: Population Health 121

128 Heart and Stroke Foundation Research Report The Sanofi-Aventis Dr. Pierre Pagé (Hôpital du Sacré-Cœur de Montréal) $10,000 The Alfred B. Grossman Award of the EJLB Foundation Dr. Yves Joanette (Institut universitaire de gériatrie de Montréal) $5,000 The Birks Family Foundation Award Dr. Damien Garcia (CRCHUM) $5,000 Training bursaries for PhD students in Cardiovascular and Stroke Research Partnership between the Fonds de la recherche en santé du Québec (FRSQ), the Réseau en santé cardiovasculaire (RSCV) and the Heart and Stroke Foundation of Québec (HSFQ). The partners offer training bursaries for PhD students working with researchers receiving a Grant-in-Aid from the Heart and Stroke Foundation of Québec (HSFQ). In, 2 bursaries were given: Sean Wiltshire (Dr. Silvia Vidal, McGill ) $6, rd year Artavazd Tadevosyan (Dr. Stanley Nattel, Montreal Heart Institute) $6, st year Research Programs in Partnership Partnership between the Sainte-Justine UHC Foundation and the Heart and Stroke Foundation of Québec for the CIRCUIT program. This program helps children and youth with cardiovascular disease to be physically more active. Dr Marie Lambert (Ste-Justine s Health Center Foundation) $15,000 Nova Scotia Dr. Gregory Ferrier Award Award: $5,000 Awardee Institute Project Pasumarthi, Kishore Babu S Dalhousie Characterization of proteins regulating cardiomyocyte cell cycle. BrightRed Graduate Research Award Award: $5,000 Awardee Institute Project Champod, Anne Sophie Dalhousie New approaches to training attentional processes in stroke patients. DeClercq, Vanessa Dalhousie Effects of dietary fatty acids and fish peptides on assembly and secretion of adiponectin oligomers from adipocytes and oligomer influence on liver metabolism. Ishigami, Yoko Dalhousie Rehabilitation of attention deficits I aging and aging-related disorders. MacMillan, Carolyn Jo-Anne Dalhousie Modulation of blood-brain barrier permeability following acute ischemic stroke. Parks, Randi Dalhousie Role of camp/pka pathway in sex differences in cardiac contractile function. Wilson, Kenneth Ryan Dalhousie The impact of distractors on working memory. 122

129 APPENDIX G RESEARCH COMMITTEE MEMBERS Photo: Dr. Ian Dixon (St. Boniface G.H. Research Centre) served on the Heart and Stroke Foundation of Canada s Scientific Review Committee in.

130 Heart and Stroke Foundation Research Report Research Policy and Planning Advisory Committee Linda Waverley, PhD, Chair Laurie Morrison, MD, Vice Chair St. Michael s Hospital Mark Bisby Irfhan Rawji Chair, Heart and Stroke Foundation of Canada Board of Directors Ex-Officio Bobbe Wood CEO, Heart and Stroke Foundation of Canada Ex-Officio Marla Gold McGill Ed Pryzdial, PhD British Columbia Margaret L. Rand, PhD Hospital for Sick Children Wendy Rodgers Alberta Arturo Tamayo, MD Manitoba Todd Anderson, MD Chair, Scientific Review Committee Foothills Hospital Scientific Review Committee Leadership Todd Anderson, MD, Chair Foothills Hospital Peter Backx, DVM, PhD, Vice Chair Toronto Clinical cardiovascular and cerebrovascular research: mechanistic studies and clinical trials / health services research (A) Mark Crowther, MD, Chair McMaster Michael D. Hill, MD, Deputy Chair Foothills Hospital Clinical cardiovascular and cerebrovascular research: mechanistic studies and clinical trials / health services research (B) Rob Beanlands, MD, Chair Ottawa Heart Institute Andrew Krahn, MD, Deputy Chair London Health Sciences Centre Integrative studies: genetic manipulations / imaging / bioengineering Evangelos Michelakis, MD, Chair Alberta Richard Frayne, PhD, Deputy Chair Calgary Basic science stroke / neurophysiology / neuroregulation Timothy H. Murphy, PhD, Chair British Columbia Peter Stys, MD, Deputy Chair Hotchkiss Brain Institute Cellular biochemistry, pharmacology and electrophysiology (A) Christopher Triggle, PhD, Chair Weill Cornell Medical College, Qatar Ian Dixon, PhD, Deputy Chair St. Boniface Hospital Research Centre 124

131 Heart and Stroke Foundation Research Report Cellular biochemistry, pharmacology and electrophysiology (B) Rhian Touyz, MD, PhD, Chair Ottawa Lucie Parent, PhD, Deputy Chair Université de Montréal Cellular biochemistry, pharmacology and electrophysiology (C) Glen F. Tibbits, PhD, Chair Simon Fraser Jason R.B. Dyck, PhD, Deputy Chair Alberta Molecular basis of cardiac and vascular function Lorrie Kirshenbaum, PhD, Chair St. Boniface Hospital Research Centre Lynn Megeney, PhD, Deputy Chair Ottawa Health Research Institute Thrombosis / lipids and lipoproteins / fundamental nutrition research Richard Lehner, PhD, Chair Alberta Mark Blostein, MD, Deputy Chair Jewish General Hospital Behavioural research / health psychology / rehabilitation / population health Wendy Rodgers, PhD, Chair Alberta Scott Lear, PhD, Deputy Chair Simon Fraser Senior Personnel (New Investigator / Career Investigator) Peter Backx, DVM, PhD, Chair Toronto John D. Parker, MD, Deputy Chair Mount Sinai Hospital Research Fellowships Debbie Saucier, PhD, Chair Lethbridge Provincial Research Advisory Committee Chairs Heart and Stroke Foundation of British Columbia and Yukon Research Advisory Committee Glen F. Tibbits, PhD, Chair Simon Fraser Heart and Stroke Foundation of Alberta, Northwest Territories and Nunavut Research and Medical Advisory Committee Henry Duff, MD, Chair Calgary Heart and Stroke Foundation of Saskatchewan Research Advisory Committee Noreen Johns, Chair Heart and Stroke Foundation of Manitoba Research Advisory Committee Michelle Nelson, Chair Manitoba Heart and Stroke Foundation of Manitoba Research Advisory Committee Mark G. Torchia, Chair Manitoba Heart and Stroke Foundation of Ontario Grant Allocation Sub-Committee David Lillicrap, MD, Chair Queen s Heart and Stroke Foundation of Ontario Research Committee Geoffrey J. Pickering, MD, PhD, Chair London Health Sciences Centre Comité scientifique de la Fondation des maladies du coeur du Québec Pedro D Orléans-Juste, PhD, Président Université de Sherbrooke Heart and Stroke Foundation of New Brunswick Medical Advisory Committee Marc Pelletier, MD, Chair New Brunswick Heart Centre Heart and Stroke Foundation of Nova Scotia Scientific Advisory Committee Marilyn MacKay-Lyons, PhD, Chair Dalhousie 125

132 Heart and Stroke Foundation Research Report 126

133 APPENDIX H DEFINITION OF HEALTH RESEARCH THEMES Photo: Millie Graham served on the Heart and Stroke Foundation of Canada s Lay Review Committee.

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