ischemic stroke, transient ischemic attack, or peripheral artery embolism
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1 Appendix Table S1: ICD- 8/1 codes and ATC- codes Population Acute myocardial infarction Defined from primary inpatient diagnoses codes PCI Defined from procedure codes Non- valvular atrial fibrillation atrial fibrillation and absence of diagnosis codes of valvular atrial fibrillation and mitral- or aortic valve surgery. ICD- 1:I21, I22 NCSP: KFNG Presence of: ICD8: 42793, ICD1: I48 Absence of: ICD8: 424, 4241, , 3958, 3959, , 3968, 3969 ICD1: Z952, Z954, I5, I6, I8A, I81A, I82A, I83A NCSP: KFKD, KFKH, KFMD, KFMH, KFGE, KFJF Vitamin K antagonist Defined from ATC- code ATC: B1AA3, B1AA4 Dabigatran Defined from ATC- code ATC: B1AE7 Rivaroxaban Defined from ATC- code ATC: B1AF1 Apixaban Defined from ATC- code ATC: B1AF2 Acetylsalicylic acid Defined from ATC- code ATC: B1AC6, N2BA1 Clopidogrel Defined from ATC- code ATC: B1AC4 Ticagrelor Defined from ATC- code ATC: B1AC22 Prasurgel Defined from ATC- code ATC: B1AC24 Comorbidities Defined from a primary or secondary in- patient or outpatient diagnosis Previous stroke ischemic stroke, transient ischemic attack, or peripheral artery embolism ICD1: I63, I64, I74, G458, G459 Ischemic heart disease Defined from diagnosis ICD1: I2- I25 Peripheral artery disease Defined from diagnosis ICD1: I7 Heart failure Defined from diagnosis ICD1: I42, I5, I11, J81 Diabetes mellitus Defined from medication for diabetes mellitus ATC: A1 Hypertension Defined from treatment with at least two classes of antihypertensive drugs: adrenergic α- antagonists, ATC: C2A, C2B, C2C, C2L, C3A, C3B, C3D, C3E, C3X, C7B, C7C, C7D, C8G, C2DA, C9BA,
2 non- loop diuretics, vasodilators, beta- blockers, calcium channel blockers and renin- angiotension system inhibitors C9DA, C2DB, C2DD, C2DG, C7A, C7B, C7C, C7D, C7F, C8, C9BB, C9DB, C9AA, C9BA, C9BB, C9CA, C9DA, C9DB, C9XA2, C9XA52 Chronic kidney disease Liver disease Previous bleeding Alcohol abuse chronic glomerulonephritis, chronic tubulointestinal nephropathy, diabetic, and hypertensive nephropathy among others chronic liver disease, cirrhosis and hepatitis intracranial bleeding, major gastrointestinal bleeding, respiratory or urinary tract bleeding, and bleeding due to anemia Defined from alcohol- related diagnosis codes or at least one dispensed prescription of an alcohol antagonist drug used to treat chronic alcoholism ICD1: N2, N3, N4, N5, N6, N7, N8, N11, N12, N14, N18, N19, N26,N158, N159, N16,N162, N163, N164,N168, Q61, E12, E112,E132,E142, I12, M321B ICD1: B15- B19, C22, D684C, I982, K7- K77, Q618A, Z944 ICD1: D5, D62, G951A, H52A, H313, H356, H431, H45, I312, I6- I62, I85, I864A, J942, K228F, K298A, K25, K252, K254, K256, K26, K262, K264, K266, K27, K272, K274, K276, K28, K282, K284, K286, K625, K661, K638B, K638C, K838F, K868G, K92, K921, K922, N2, R4, R31, S64, S65, S66, S368D ICD1: E244, E52, F1, G312, G621, G721, I426, K292, K7, K86, L278A, O354, T51, Z714, Z721 ATC: N7BB Concomitant medication Non- steroidal anti- inflammatory drugs Defined from ATC- codes ATC: M1A without M1AX5 Loop diuretics Defined from ATC- codes ATC: C3C Beta- blockers Defined from ATC- codes ATC: C7A, C7B, C7C, C7D, C7F Calcium channel blockers Defined from ATC- codes ATC: C8, C9BB, C9DB Renin- angiotensin system inhibitors Defined from ATC- codes ATC: C9AA, C9BA, C9BB, C9CA, C9DA, C9DB, C9XA2, C9XA52 Digoxin Defined from ATC- codes ATC: C1A Statins Defined from ATC- codes ATC: CIAA PPI Defined from ATC- codes ATC: A2BC
3 Patients, % (1.2%) (38.6%) (43.1%) (8.1%) (11.9%) (4.%) (39.6%) (8.5%) (8.9%) (36.2%) (4.9%) (14.%) (11.6%) (35.9%) (35.%) (17.7%) (6.7%) (32.4%) (44.1%) (16.8%) + (8.1%) (29.8%) (43.4%) (18.7%) + CHA2DS2-VASc > Figure S1: Title: CHA2DS2- VASc score Legend: Distribution of CHA2DS2- VASc score according to treatment group Patients, % (35.%) (46.5%) (16.6%) (31.5%) (45.8%) (2.4%) (34.%) (48.2%) (14.9%) (29.6%) (49.%) (16.4%) (32.8%) (45.8%) (18.8%) + (26.3%) (43.8%) (26.7%) + HASBLED >2 2 1 Figure S2: Title: HAS- BLED score Legend: Distribution of HAS- BLED score according to treatment group
4 Female Sex Male 1 75 Percent (%) 5 Treatment groups Years Figure S3: Title: Treatment preference according to sex Legend: Treatment preference within subgroups of sex from 22 nd of August 211 to 3 th of September 216..
5 No previous bleeding Bleeding Previous bleeding 1 75 Percent (%) 5 Treatment groups Years Figure S4: Title: Treatment preference according to previous or no previous bleeding Legend: Treatment preference according to previous or no previous bleeding from 22 nd of August 211 to 3 th of September 216.
6 No previous stroke Stroke Previous stroke 1 75 Percent (%) 5 Treatment groups Years Figure S5: Title: Treatment preference according to previous or no previous stroke Legend: Treatment preference according to previous or no previous stroke from 22 nd of August 211 to 3 th of September 216..
7
Condition Congestive heart failure I11.0; I13.0; I13.2; I42.0; I50 CO3C Left ventricular dysfunction I50.1; I50.9 E11 1; E11 9
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