OrbusNeich at TCT Late Breaking, Presentations and Poster Sessions

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1 OrbusNeich at TCT Late Breaking, Presentations and Poster Sessions Booth No: 3011

2 MONDAY, OCTOBER 30 Special Session: 15th Anniversary HBD (Harmonization By Doing): New Synergies in Japan-U.S. Research Opportunities for Global Medical Device Innovation 9:00 am - 5:00 pm Room 703, Meeting Room Level Session II: HBD POC Updates: Novel Coronary & Vascular 10:00 am - 11:00 am 10:00 am Japan-USA Coronary Stent Innovation: EPC Capture Steve Rowland First Report Investigations 1 12:00 noon - 1:00 pm Main Arena I 12:15 pm HARMONEE: A Randomized Trial of a Bioabsorbable Mitchell Krucoff Polymer-Based DES with a Luminal CD34+ Antibody Coating vs a Durable Polymer-Based DES in Patients with Coronary Artery Disease

3 TUESDAY, OCTOBER 31 Moderated Poster Session: New BRS 9:30 am - 10:30 am Moderated Posters 4 Exhibit Hall, Exhibit Level 9:42 am TCT 329: Twelve-Month Follow-Up of a Novel Thin Yanping Cheng Strut (112 µm) Sirolimus-Eluting Absorbable Vascular Scaffold in Porcine Coronary Arteries Moderated Poster Session: COMBO Stent Studies 11:30 am - 12:30 pm Moderated Posters 8 Exhibit Hall, Exhibit Level 11:30 am TCT 427: Three Year Clinical Performance of the Deborah Kalkman Dual-Therapy COMBO Stent: Insights From the REMEDEE Registry 11:54 am TCT 429: Comparison of the Clinical Performance Deborah Kalkman Between COMBO and Xience Stent at One Year Follow-Up in All-Comers Patients 12:06 pm TCT 430: Nine-Month Angiographic and 1-Year Clinical Gu Wen Yi Outcomes of the RECOVERY Study: A Randomized Trial Evaluating the Safety and Efficacy of the COMBO Bio-Engineered Sirolimus-Eluting Stent Versus the Nano Polymer-Free Sirolimus-Eluting Stent in Patients

4 TUESDAY, OCTOBER 31 (concurrent sessions) COMBO TM Plus EPC Capture DES: Beyond Proven Concept to Hard Clinical Evidence 11:30 am 12:30 pm Presentation Theater 4 11:30 am True Healing and Restored Functional Endothelium Renu Virmani 11:36 am Can DAPT Flexibility Benefit TAVR Patients Receiving PCI? Pieter Stella 11:44 am How Can COMBO Benefit AMI Patients? Huay Cheem Tan 11:52 am COMBO Left Main Registry Michael Joner 12:00 pm Hard Evidence from the COMBO Clinical Program Roxana Mehran 12:10 pm Discussion 12:25 pm Closing Remarks Robbert de Winter Featured Clinical Research I: Presented to the Editors of Circulation 12:00 pm - 1:00 pm Room 703, Meeting Room Level 12:15 pm RECOVERY: A Randomized Trial of a Bioabsorbable Ling Tao Polymer-Based Metallic DES with a Luminal CD34+ Antibody Coating vs a Polymer-free Metallic DES in Patients with Coronary Artery Disease

5 TUESDAY, OCTOBER 31 (concurrent sessions) Oral Abstract Session 2B: Healing After DES Implantation 1:00 pm - 2:00 pm Room 501, Meeting Room Level 1:15 pm TCT 94: Safety and Efficacy of the COMBO Bio-engineered Jaya Chandrasekar Stent in an All-Comer PCI Cohort - Results from the MASCOT Post-marketing Registry TCT360: Metallic Stents Devices and Outcomes Part II Session V. Bioabsorbable Polymer-Based Metallic DES Part 2: Emerging Technologies 3:00 am - 4:01 pm Room 210, Meeting Room Level 3:00 pm The COMBO Stent: From Concept to Clinical Performance Roxana Mehran Next generation DES Technology: Let the Future Begin! 6:30 pm - 8:00 pm Hyatt Regency Hotel, Continental Ballroom F-H Session II: The Case for Bioresorbable Polymer DES 7:10 pm Bioresorbable Polymer-based Drug Delivery with Roxana Mehran Endothelial Progenitor Cells to Accelerate Healing: The COMBO Stent Evening Program: The Approach to the High Bleeding Risk Patient 6:30 pm - 8:00 pm Hyatt Regency Hotel Session 2: Bleeding Avoidance Strategies: Stent Choices 7:12 pm COMBO REDUCE Harry Suryapranata

6 WEDNESDAY, NOVEMBER 1 Late-Breaking Clinical Trial 3: Co-sponsored by the Journal of the American Medical Association 11:00 am - 12:00 noon Main Arena III 11:40 am REDUCE: A Randomized Trial of 3-Month vs 12-Month Harry Suryapranata DAPT After Implantation of a Bioabsorbable Polymer-Based Metallic DES with a Luminal CD34+ Antibody Coating in Patients with ACS Meet the COMBO TM Trialists Dive Deep, Putting It All Together 1:00 pm 2:00 pm Presentation Theater 4 1:00 pm Welcome and Introductions The COMBO Platform Roxana Mehran 1:05 pm HARMONEE Topline Results & Implications Mitchell Krucoff 1:12 pm RECOVERY Topline Results & Implications Ling Tao 1:29 pm REDUCE Topline Results & Implications Harry Suryapranata 1:36 pm MASCOT Topline Results & Implications Jaya Chandrasekar 1:53 pm Closing Putting It All Together Martin B. Leon COMBO is an investigational device. Not approved for sale in the USA

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FOR IMMEDIATE RELEASE FOR IMMEDIATE RELEASE Global Media Contacts: David Schull or Ian Stone Russo Partners +1 212-845-4271 +1 619-528-2220 david.schull@russopartnersllc.com ian.stone@russopartnersllc.com David Kujawa OrbusNeich

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