DISCLOSURES ISOLATED DTA LESION? TYPE B DISSECTIONS TREATMENT OPTIONS
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1 Endovascular Repair of Aortic Arch Pathologies; What is available/possible in the U.S. in 2018? Kaiser Permanente Endovascular Symposium 6/2/18 Sukgu M Han, MD, MS Assistant Professor of Clinical Surgery Co-director, Comprehensive Aortic Center Division of Vascular Sugery and Endovascular Therapy Keck Medical Center of USC Sukgu.han@med.usc.edu DISCLOSURES Cook Medical: Consultant, Proctor for TX2, Zenith, Alpha, Zenith Fenestrated Gore & Associates: Consultant 2 ISOLATED DTA LESION? Degenerative Aneurysms 60% in ascending aorta 10% arch aneurysm Descending thoracic aortic aneurysm approaching arch branch vessels Aortic Dissections 2/3 Type A, 1/3 Type B Post type A repairs with residual arch, thoracoabdominal dissection TYPE B DISSECTIONS Median distance (mm) Overall (range) Group A Group B p 1. Innominate to LCCA 8.7 (0 16.6) 8.3 (0 12.8) 8.9 (0 16.6) LCCA to LSCA 17.2 ( ) 17.1 ( ) 17.8 ( ) LSCA to IMH 0 ( ) 0 ( ) 3.5 ( ) LSCA to entry tear 35.6 ( ) 20.2 ( ) 36 ( ) TREATMENT OPTIONS Open repair Hybrid repair Parallel grafting TEVAR Fenestrated/Branched TEVAR TREATMENT OPTIONS Open repair Hybrid repair Parallel grafting TEVAR Fenestrated/Branched TEVAR 5 6 1
2 HYBRID REPAIRS HYBRID REPAIRS Meta analysis of total arch debranching + TEVAR Type I reconstruction 10.8% endoleak 3.9% 30 day mortality Type II reconstruction 12.5% endoleak 5.3% 30 day mortality 2.5% stroke 7 Papakonstantinou et al. Heart, Lung, Circulation PARALLEL GRAFTING PARALLEL GRAFTING N=27 high risk pts with 32 target arch branches 33% emergent cases 4% 30 day mortality (N=1) 100% primary branch patency at 9 months 11% stroke (N=3) 33% aortic reintervention (N=9) 9 Voskrensensky et al. JVS Case
3 Postop CTA Potential advantages over other endovascular LSCA incorporation Setting up for future Facilitates proximal extension with fenestrated/branched arch TEVAR Facilitates distal extension TEVAR Preserves L SCA path to visceral/renal targets for fenestrated/branched EVAR IN SITU FENESTRATION Systematic review 34 articles 58 pts with 73 fens 3.4% 30 day mortality due to aorto aerodigestive fistulae 1.7% L SCA restenosis Needle, Stiff wire, Energy (RFA, Laser) Less fabric tear with Dacron and Laser 17 Glorion et al. Eur J Vasc Endovasc Surg
4 CASE 75 M underwent emergent ascending, arch replacement with frozen elephant trunk procedure for type A aortic dissection Antegrade deployment of 34mm x 15cm ctag) POSTOP COURSE tered mental with decreased L CCA flow Altered mental status Pseudoaneurysm at the carotid BPG anastomosis Dissection of L CCA to proximal ICA L CCA REPAIR mental with decreased L CCA flow Left CEA exposure Interposition graft CCA to ICA Bridging Viabahn Covered Stent from intrathoracic CCA to cervical CCA POSTOP COURSE Dizziness, left arm, hand weakness with left arm exercise during rehab Duplex: retrograde flow in left vertebral artery IN-SITU LASER FENESTRATION BRANCHED, FENESTRATED TEVAR
5 FENESTRATED TEVAR Cook Arch Fenestrated Preloaded catheter N=15 high risk pts 6 Post dissection 9 Aneurysms 93% technical success 20% 30 day mortality 1 stroke, 1 access complication, 1 MI FENESTRATED TEVAR Najuta Fenestrated Custom precurved Unreinforced fen N=32 91% Technical Success 2 RTAD, 1 Stroke, 1 SCI, 1 Celiac occlusion 97% Branch Patency at 3 years Tsilimparis et al. JVS Iwakoshi et al. JVS MULTIBRANCHED TEVAR MULTIBRANCHED TEVAR Cook Inner Branch Custom dual branch Curved delivery system Bullet nose cone option N=27 0% 30 day mortality 7.4% major stroke 3.4% minor stroke 7.4% transient SCI Bolton Relay Mutlibranch Custom dual branch Curved delivery system Two internal branch cuffs for innominate and CCA No pre wire/catheters Spear et al. Eur J Vasc Endovasc Surg MULTIBRANCHED TEVAR SINGLE BRANCHED TEVAR Inoue Arch Graft Custom Unibody Graft (1~3 branches) N=89 (64 single, 18 double, 7 triple branches) 4.5% 30 day mortality (29% triple branches) 16% stroke (33% double, 42% triple) Medtronic Mona LSA Off the shelf Designed for zone 2 Requires 10mm between CCA and LSCA, 5mm LSCA and aneurysm, 20mm proximal seal N=9 4 minor strokes Tazaki et al. JVS
6 SINGLE BRANCHED TEVAR CASE Gore TBE Off the shelf: 8mm, 12mm inner portal N=22 Zone 2 with LSCA branch stent 0% 30 day mortality, stroke, SCI 100% branch 1mo Multi center Pivotal Trial Including Zone 0,1,2 Dissection, Aneurysm, Transection Patel et al. Ann Thoracic Surg Persistent chest pain Repeat CTA 2 days later Plan 31mm TAC084015C BND14102C
7 37 38 CONCLUSIONS Hybrid repair allows proximal extension of seal zone Parallel grafting TEVAR and In situ Fenestrated TEVAR enables total endovascular arch repair in urgent settings Fenestrated, Branched TEVAR rapidly evolving technology THANK YOU! 41 7
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