ritical Care Review Early Intervention in Respiratory Distress Syndrome Stephen Minton, MD, Dale Gerstmann, MD, Ronald Stoddard, MD

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1 ritical Care Review CURRENT APPLICATIONS AND ECONOMICS Early Intervention in Respiratory Distress Syndrome Stephen Minton, MD, Dale Gerstmann, MD, Ronald Stoddard, MD Introduction Since its availability in the late 1960's, mechanical ventilation has led to dramatic improvements in treating infants with hyaline membrane disease (HMD).1 Conventional mechanical ventilators provide relatively large tidal volumes to eliminate carbon dioxide and establish an adequate gas exchanging volume to reduce shunting. In 1959, Mead and Collier showed that without periodic inflation with lung volume recruitment, there was a progressive fall in compliance during prolonged mechanical ventilation.2 Since the introduction of this concept, clinicians have been searching for better methods of lung volume recruitment in acute lung disease. To achieve adequate lung volume recruitment, the lung has to be inflated past the pressure at which atelectatic alveolar units begin to open and then be maintained above their critical closing pressure. Positive pressure mechanical ventilation uses repetitive large convective flows to achieve lung volume recruitment. The lung volume in conventional ventilation is constantly changing. The repetitive stretching of distal conducting airways will cause over distention and a resultant lung injury which can become considerable. High Frequency Oscillatory Ventilation (HFOV) has been shown to be an effective method for ventilation and oxygenation not only in experimental animals with and without lung disease, but also for neonates with respiratory failure.3-8 HFOV lung volume recruitment can be safely used by employing mean lung pressures greater than those used with conventional ventilation, but without exposing the lung to high peak pressures that can lead to injury. Lung recruitment can be accomplished while using tidal volumes less than dead space, delivered at supra-physiologic ventilatory frequencies. Pulmonary Injury Sequence of Prematurity Pulmonary injury sequence (PIS) of prematurity is a continuum of disease which includes respiratory distress syndrome (RDS), pulmonary interstitial emphysema, pulmonary airleak syndrome, oxygen toxicity, and bronchopulmonary dysplasia.7 This syndrome is initiated by either spontaneous or mechanical tidal volume breaths in an infant lacking surfactant. These convective tidal volumes are distributed heterogeneously within the lung and initiate the first phase of the pulmonary injury sequence. This tidal breathing induced injury has been described in detail in our previous Critical Care Review "Pathophysiology of Lung Injury", published in Based on the etiologies discussed in our review, there are two ways by which PIS of prematurity might be prevented, correction of surfactant deficiency (pulmonary immaturity) or elimination of tidal volume respirations. Surfactant replacement therapy is now generally considered to be a standard of care for infants with RDS, significantly reducing mortality. Because of this substantial improvement, many centers question the value of adding HFOV to surfactant for early intervention. But exogenous surfactant has not proven the recent report from the New England Journal of Medicine clearly indicates that although surfactant has significantly decreased mortality from 24 to 20 percent following its introduction for treatment of RDS, morbidity remains high with the incidence of BPD increasing from 22 to 25

2 ritical Care Review CURRENT APPLICATIONS AND ECONOMICS 2 percent, IVH from 17 to 23 percent, and patent ductus arteriosus from 24 to 27 percent.10 Benefits of using HFOV in conjunction with surfactant therapy have been demonstrated in three new animal studies and a new 3 year clinical trial. These studies also provide insight as to why surfactant works better with HFOV. Froese, et al evaluated high (optimal) and low lung volume strategies with both conventional and high frequency ventilation in a surfactant deficient lung injury rabbit model treated with exogenous surfactant.11 Phospholipid levels in lamellar bodies were used as one indicator of lung injury. The optimal lung volume strategy with HFOV maintained pre-injury levels (92%) of phospholipids, while low lung volume strategies had significant decreases with both conventional (33%) and HFOV (34%). The optimal lung volume strategy with conventional ventilation resulted in an intermediate reduction (52%) of phospholipid levels. The authors concluded that the ventilator strategy strongly influences exogenous surfactant efficiency and that high lung volume HFOV enables the lung volume to be stabilized, preventing both over-distention and atelectasis. The 1994 study by Jackson, et al, reported the effects of both conventional and HFOV, with and without exogenous surfactant, on lung injury in a premature baboon model.12 They found that surfactant with HFOV was superior to surfactant with CMV, CMV alone or HFOV alone. Surfactant therapy with HFOV from the first breath dramatically reduced alveolar proteinaceous edema, alveolar debris, radiographic scores and oxygen index. They speculated that the reduction in early lung injury may reduce the incidence or severity of BPD. Recently, Matsuoka, et al, examined the levels of granulocytes in lung lavage fluid in surfactant depleted rabbits ventilated with CMV or HFOV.13 They demonstrated that animals ventilated with conventional ventilation had significant increases in granulocytes while the HFOV group maintained baseline levels, supporting the theory that HFOV is useful for the prevention of lung injury related to activated granulocytes. Alveolar Debris CMV ** In a new clinical study, the Provo multicenter controlled trial entered patients at approximately 3 hours of age.5 The incidence of moderate to severe chronic lung disease and/or death was 50% less in the HFOV-surfactant treatment group than in the CMV-surfactant group. These new data strongly support the argument that the combination of surfactant and HFOV is more effective for treating RDS than either HFOV alone or surfactant with CMV. HFOV Strategy in Early Intervention The lung volume on HFOV remains relatively constant. Recruitment of lung volume is achieved by raising MAP to move lung inflation past the critical opening pressure at which atelectatic alveolar units begin to open. Inflation is maintained above the closing pressure of the alveoli and airways. Achieving the correct lung volume and maintaining it throughout the respiratory cycle improves V/Q matching in several ways. In CMV, the alveolar gas exchange area is reduced and the time for gas exchange is short. With an optimum lung volume strategy during HFOV, the lung volume is held above the critical closing pressure throughout the respiratory cycle, the gas exchange area is enlarged, and the time for gas exchange is prolonged. Both can significantly improve the ventilation side of the V/Q relationship. Optimizing pulmonary blood flow is critical to improving V/Q matching. This can only ** CMV SURF ** HFOV ** HFOV SURF Figure 1. Percent of alveolar volume filled with debris with different ventilation methods. Jackson C., et al. (Ref 12).

3 ritical Care Review CURRENT APPLICATIONS AND ECONOMICS 3 be achieved when pulmonary vascular resistance (PVR) is minimized and cardiac output is not compromised. It has been shown that physical expansion of the lung contributes to pulmonary vasodilatation. At low lung volume, alveoli spontaneously collapse due to loss of interstitial traction. This triggers an associated decreased functional residual capacity, decreased alveolar stability, and acute hypoxemia. At a low lung volume, PVR increases secondary to a decreased cross-sectional area of the extra alveolar vessels.14,15 As the lung increases from a low to an optimum lung volume, there is an increase in radial traction to the walls of the large extraalveolar pulmonary vessels resulting in an increase in cross-sectional area and a reduction in PVR. If the lung becomes over distended, there is increased alveolar pressure compressing the alveolar vascular bed. This results in increased PVR. Thus at both under and over inflated lung volume, PVR is increased, but PVR is minimized at optimum lung volume (Fig. 2). V/Q can be monitored by changes in arterial oxygenation. Pulmonary Vascular Resistance (cmh2o/l/min) 100 Lung Volume (ml) Figure 2. Relationship between lung volume and Pulmonary Vascular Resistance (PVR). Our emphasis is in early use of HFOV to achieve "optimal" lung inflation using a "high" mean airway pressure approach before significant lung injury has occurred. Because even brief periods of tidal volume breathing can initiate pulmonary injury, we believe early high-frequency oscillation intervention can be beneficial. In the extremely premature infant, our clinical experience supports introduction of HFOV within the first hour of life, while in other infants, HFOV is initiated before 2 hours of age if possible. This is our defined time frame for preventative intervention. The clinical strategy we follow in this early time frame is depicted in Figure 3. We initiate HFOV almost always below opening pressure of the lung at a mean airway pressure (MAP) of 10 cmh 2 O, or switch from CMV to HFOV at a MAP 1-2 cmh 2 O higher than that being used on CMV. In general, lung volume while on CMV at the time of transfer to HFOV usually is on the inflation limb of the pressure volume curve as depicted by point "A" in Figure 3. We increase MAP in 1 cmh 2 O increments to increase lung volume along the pressure volume curve. These incremental changes are performed until arterial oxygen shows marked improvement, or there is a rise in central venous pressure with signs of decreased systemic blood flow, or overinflation is found on the chest radiograph. During the patient stabilization period, ventilator adjustments are made every 15, 30 or 60 minutes depending on the patient's condition and whether they are high or low on the pressure volume curve. As these incremental MAP increases are performed, FIO 2 is decreased to keep the PaO 2 in the torr and O 2 saturation in the 91-93% range. Because of concerns with diffuse oxygen toxicity in the fully recruited neonatal lung, the FIO 2 is reduced to a level of oxygen support that is less than 30 percent. Chest radiographs for assessment of lung volume are obtained every 2-6 hours as needed until lung volume is optimized. Optimal lung inflation on chest radiographs generally correlates with obtaining an 8-9 posterior rib level expansion on the right hemidiaphragm and decreased lung opacification. Ventilation is adjusted by changing the power that varies the oscillatory pressure amplitude delivered by the ventilator. Increasing the power increases the oscillatory amplitude which increases tidal volume. The need to adjust oscillatory amplitude is based on observed chest

4 ritical Care Review CURRENT APPLICATIONS AND ECONOMICS 4 HFOV "OPTIMUM" LUNG VOLUME STRATEGY EARLY INTERVENTION FOR PULMONARY INJURY SEQUENCE Infant intubated for pulmonary injury sequence without airleak HFOV MAP 10 cmh 2O Hertz 10 for 750 gm Hertz 15 for < 750 gm IT 33% P adequate for chest wall movement PCO 2 - high normal A B Conventional mechanical ventilation Switch to HFOV MAP 1-2 cmh 2O higher than on CMV Hertz 10 for 750 gm Hertz 15 for < 750 gm IT = 33% P = adequate chest wall movement PCO 2 - high normal O 2 sat begins to fall O 2 sat stable O 2 sat rises Immediately increase MAP in 1 cmh 2O increments until arterial oxygenation improves Adjust P to achieve PCO 2 45 C O 2 sat stable CXR for assessment of lung volume every 2-6 hours until optimized Continue to increase MAP in 1 cmh 2O increments every minutes decreasing FiO 2 to keep O 2 sat until: a) FiO 2 < 30% or b) oxygenation improvement ceases or c) FiO 2 increases or d) signs of decreased peripheral perfusion occur D Evaluate FiO 2 need FiO 2 < 30% FiO 2 > 30% E CXR after 1 hr Optimum lung volume generally T8-T9 on right hemidiaphram without intercostal bulging On CXR diaph below T9 or intercostal bulging Wean MAP 1-2 cm Evaluate cardiovascular status F Evaluate lung volume CXR Consider Non- RDS Diagnosis Evaluate blood volume CVP ECHO BP/CRT Evaluate myocardial function ECHO Adjust P for PCO 2 40 May be able to wean 1-2 cm without losing lung volume (on deflation limb or P/V curve) FiO 2 < 30% R hemidaphragm < T9 go to F consider hypoplasia R hemidiaphragm T8-9 go to F R hemidiaphragm > T9 - wean MAP and go to D as indicated FiO2 < 30% FiO2 < 30% Go to STEP E If low, give blood volume expansion If normal but BP decreased, begin dopamine If decreased, begin dobutamine Follow CXR for lung volume Q6H x 24 hr then Q12H Begin turning infant at 24 hr Sectioning: 1) Prior to hr. PRN 2) Routine suctioning at 24 hr Q4H, PRN unless nonindicated Go to STEP C G Go to weaning protocol Figure 4. *Follow arrows on protocol. Letters do not necessarily follow in sequence.

5 ritical Care Review CURRENT APPLICATIONS AND ECONOMICS 5 movement (vibration) and arterial blood gas results. We use a rate of 10 Hz and an I:E ratio of 1:2 in most neonates. In very low birth weight infants, we use 15 Hz to enable finer control of tidal volume and to prevent over ventilation CONTROL POSTLAVAGE 5 POSTSURFACTANT A AIRWAY PRESSURE (cmh 2 O) Figure 3. Pressure volume curves from Froese A, et al. (Ref 11). Transcutaneous monitoring of carbon dioxide levels facilitates the decision making process and is extremely beneficial in preventing inadvertent hyperventilation. It is important to remember that as one increases MAP and approaches an optimum lung volume, compliance improves and tidal volume increases. This compliance improvement can be rapid, requiring an almost immediate decrease in oscillatory amplitude. Therefore as we increase MAP to establish an optimal lung volume, we adjust oscillatory amplitude to keep PaCO 2 approximately 45 torr until lung volume is optimized. We then adjust oscillatory amplitude to fine tune PaCO 2 to 40 torr. In severe respiratory failure, if adequate PaCO 2 cannot be achieved with maximum power output, decreasing the oscillatory frequency will increase tidal volume and improve ventilation. However, frequency changes are generally not needed, and 10 Hz usually provides an adequate range of tidal volume output. In extremely low birth weight infants, over-ventilation at low power output is occasionally seen and increasing the frequency will result in more attenuation of the tidal volume, reducing ventilation. HFOV Weaning After radiographically optimizing lung volume with an FIO 2 less than 0.30, we slowly begin to reduce mean airway pressure. Because of the hysteresis of the pressure volume relationship of the lung on the deflation limb, the reduction in MAP will generally not result in a significant loss of lung volume and will maintain oxygenation. If weaning is overly aggressive, the lung may drop below the critical closing pressure and oxygenation may suddenly fall. Because the lung volume has now shifted back to the inflation limb it may require more than simply increasing MAP HFOV "OPTIMUM" LUNG VOLUME STRATEGY PULMONARY INJURY SEQUENCE WITHOUT AIRLEAK WEANING STRATEGY On CXR diaph at or above T9 and FiO 2 < 25% Wean MAP slowly in cmh 2O increments until FiO 2 rises 2-3% Adjust P to keep PCO 2=40 If FIO 2 increases > 30%, go to "E" on optimum lung volume strategy flowchart Extubated to canopy FiO 2 Follow CXR for lung volume Q6H x 24 hr then Q12H On CXR diaph above T9 and FiO % Try to wean MAP slowly in 0.5 cmh 2O increments until FiO 2 rises 2-3% Adjust P to keep PCO 2=40 Repeat above until either a) MAP 6 cmh 20 and FiO 2 < 30% b) Secretions are a problem c) Unable to wean Figure 5. Optimum Lung Volume Strategy Flowchart G CMV IMV 6 For several hours for pulmonary toilet, stimulate diaphragms, and possibly to improve surfactant secretion On CXR diaph below T9 Wean MAP in 1 cmh 2O increments until FiO 2 increases to between 25-30% (Weaning below critical closing pressure will drop from deflation to inflation limb of curve and will need to reinflate along curve again) If FiO 2 remains > 30%, go to "E" on optimum lung volume strategy flowchart

6 ritical Care Review CURRENT APPLICATIONS AND ECONOMICS cm to re-recruit the lung. Re-recruiting the lung volume must be done by increasing pressure up the inflation limb to an optimum lung volume and then slowing decreasing MAP and lung volume on the deflation limb. An alternative recruitment method would be to open the lung with sighs. Increasing the MAP along the pressure volume curve will result in increasing lung volume. When lung volume increases above the critical opening pressure, lung compliance will improve. Over time, lung compliance will continue to improve, and when not compensated for by decreased MAP, will result in continued lung volume increases and eventually, overdistension. This causes compression of the alveolar vascular bed and increased PVR, or decreased venous return, and decreased cardiac output. Chest radiographs are utilized to evaluate lung over-inflation. We consider the lung over-inflated radiographically when the diaphragm is flattened, or when bulging is noted in the intercostal spaces. If hypovolemia is present, a negative effect on pulmonary circulation may be experienced at an otherwise normal appearing lung volume. The weaning strategy we follow is depicted in Figure 5. We decrease MAP in.5 to 1 cmh 2 O increments as long as FIO 2 remains <.30. Chest radiographs are followed for lung volume assessment. Oscillatory amplitude is weaned per arterial carbon dioxide values. Because of the work by Clark, et al, showing a decreased incidence of bronchopulmonary dysplasia in patients ventilated entirely with HFOV6, it is our preference to maintain infants on HFOV until they are weaned to CPAP. HFOV weaning problems are usually evidenced by restlessness, increased retractions, fluctuations in mean airway pressure and a decrease in saturation. These may be related to inadequate lung inflation. Some patients fail to wean successfully to CPAP from HFOV and these patients are changed to conventional ventilation. They remain on conventional ventilation if they can maintain FIO 2 less than 0.30 and mean airway pressure less than 8 cmh2o for infants weighing less than 1000 gms; or a mean airway pressure less than 10 cmh 2 O for infants weighing more than 1000 gms. We do not hesitate to place an infant back on HFOV if they fail a CMV trial. If mucus plugging of the airways is a serious problem in the recovery phase of illness, this type of patient may also be changed from HFOV to conventional ventilation to improve mucus transport and recovery. While on HFOV, we monitor closely for signs of decreased systemic perfusion. Studies have shown that carefully increasing mean airway pressure as we have previously described, is similar to conventional ventilation in its effect on cardiac output.16 However, many of our patients may have limited cardiac reserves and these require careful echocardiographic assessment: indices of myocardial function such as shortening fraction, ejection fraction and estimates of chamber sizes, ductal shunting, pulmonary artery pressure and cardiac output. Our clinical experience in these patients has been that infants placed on HFOV are less tolerant of myocardial dysfunction or hypovolemia than conventionally ventilated newborns. If the patient has myocardial dysfunction or hypovolemia and inotropics or appropriate blood volume expansion are not given, there may be ventilation perfusion mismatches which will counter the positive oxygenation effects of optimal lung volume recruitment. Suctioning while on HFOV currently requires disconnecting the circuit to suction through the endotracheal tube. This will result in a fall in MAP and loss of lung volume and FRC if the patient is surfactant deficient. Once HFOV is reinstituted, mean airway pressure may need to be increased above the previous mean airway pressure settings to obtain re-recruitment. This is usually accomplished at a MAP 1-2 cm higher than the baseline MAP with weaning to the baseline MAP as oxygenation improves. In our experience with early institution of HFOV, frequent suctioning is not required in the first hours; however, as compliance improves, we routinely suction every

7 ritical Care Review CURRENT APPLICATIONS AND ECONOMICS hours. As previously mentioned, surfactant replacement therapy is now considered to be a standard of care for infants with RDS. However, to instill exogenous surfactant into the ET tube while on high-frequency oscillation currently requires interrupting the circuit with loss of mean lung volume. This necessitates re-recruitment of lung volume after instillation. Re-recruitment can usually be accomplished over time with the same mean airway pressure or by temporarily increasing mean airway pressure by 1-2 cmh 2 O from the previous baseline and then weaning back to baseline mean airway pressure as oxygenation improves. Since our ventilatory strategy results in a rapid reduction in FIO 2 to less than 0.30 (i.e. below surfactant replacement indication levels), subsequent doses of surfactant are less frequently needed for HFOV ventilated infants. Potential Complications All therapeutic ventilatory modalities have potential adverse effects, and HFOV is not different in this respect. Major factors that have been studied or proposed as potential complications of HFOV are focal obstruction/ mucus impaction, over inflation of the lung, impaired cardiac output, and intraventricular hemorrhage. Focal obstruction secondary to mucus impaction has been reported after prolonged use of HFOV.17 The small tidal volumes of HFOV may not breathe "through" mucus plugging effectively. Loss of chest wall movement may be an indication of mucus plugging which would require suctioning. When mucus secretions are not responsive to frequent suctioning, we often transfer the patient to conventional ventilation for short periods of CMV, or for continuous CMV if necessary. We have noted some patients on prolonged HFOV who have a large mobilization of secretions after return to conventional ventilation. These usually have been infants who had significant barotrauma before HFOV rescue. Mucus impaction may also be related to inadequate humidification. Early enthusiasm for high-frequency ventilation was tempered by a concern that high lung volumes could have an adverse effect on venous return and cardiac output. Studies comparing cardiac output during high-frequency and conventional ventilation have failed to reveal differences between the two techniques.16 However, lung over-distention can cause cardiovascular compromise. We have noted in many of our patients the need for more fluids during the first 24 hours of HFOV than we would usually need during conventional ventilation. Monitoring for adverse hemodynamic effects should include continuous heart rate, blood pressure, and central venous pressure monitoring. Frequent echocardiographic evaluations for measurement of myocardial function and blood volume status are extremely helpful. In addition, frequent lung volume assessment with serial chest x-rays should be performed. With careful attention to blood volume status and correction of myocardial dysfunction, we have found HFOV to be an effective method of ventilation and oxygenation even in septic infants. Animal studies evaluating central venous pressure, cerebral blood flow and intracranial pressure have not shown differences when HFOV has been compared to conventional ventilation.16,18 In the very premature infant, HFOV can result in elevated pleural pressure and fluctuations of arterial venous pressure which may increase the risk of intraventricular hemorrhage. In the multicenter National Institute of Health High-Frequency Oscillation (HIFI) trial, infants treated with HFOV had an increased incidence of severe intraventricular hemorrhage compared to those managed with conventional ventilation.19 These infants had varying periods of conventional ventilation before HFOV and their ventilator approach was probably more a low than a high lung volume strategy. In addition there was a large difference between centers in Grade 3-4 IVH. A two year neurodevelopmental follow-up of those patients demonstrated no statistical difference in outcome between groups.20

8 ritical Care Review CURRENT APPLICATIONS AND ECONOMICS 8 In 1993, the University of Iowa reported on the use of HFOV with surfactant in RDS as compared to infants treated with conventional ventilation and surfactant.21 Despite a lower birth weight (762 grams vs grams) and more severe RDS, defined as MAPxFIO 2 (9.7 vs. 7.1), in the HFOV treated patients, they had non-significant but lower incidences of pneumothorax (7.7% vs. 16%) and severe IVH (15% vs. 24%). Three other studies, all in infants with severe respiratory distress syndrome using an optimum lung volume strategy, have not found a significant increase in severe intraventricular hemorrhage.5,8,22 A recent single center review of their two-year HFOV experience reported a drop in severe IVH in the first 104 infants with RDS treated with HFOV compared to their previous experience with conventional ventilation. They found the incidence of Grade 3-4 IVH to be down to 3.1% in their infants treated with HFOV, a reduction from 7.4% during previous use of CMV only.23 At the 1994 HFV meeting at Snowbird, Alan Spitzer, M.D., from Jefferson University Hospital in Philadelphia, reported on their analysis of high frequency ventilation relationships to neurological complications. They found that low PaCO 2 's had the highest correlation to neurologic complications.24 It may be that HFV is such an effective ventilator that unmonitored hyperventilation may set up some infants for vascular lesions. Summary We believe HFOV is an important tool in the management of neonates with respiratory distress and is effective in breaking the continuum of pulmonary injury sequence. There is a definite learning curve to the safe introduction of HFOV. As with any new technology, there is an ongoing process of determining optimum ventilation strategies for clinical management of neonates with varying types of respiratory failure. In the infant with RDS, early use of HFOV with a strategy to achieve effective, i.e. "optimal" lung recruitment, in combination with exogenous surfactant administration, may be the best treatment combination currently available. References 1 delemos RA, McLaughlin GW, Robison EJ, et al. Continuous positive airway pressure as an adjunct to mechanical ventilation in the newborn with respiratory distress syndrome. Anesth Analg 52:328, Mead J, Collier C. Relation of volume history of lungs to respiratory mechanics in anesthetized dogs. J Applied Physiol 14:669, Bell RE, Kuehl TJ, Coalson JT, et al. High frequency ventilation compared to positive pressure ventilation in the treatment of hyaline membrane disease in primates. Crit Care Med 12:764, Clark RH, Gerstmann DR, Null DM, et al. Pulmonary interstitial emphysema treated by high-frequency oscillatory ventilation. Critical Care Med 14:926, Gerstmann DR, Minton SD, Stoddard RA, et al. Results of the Provo multicenter surfactant high frequency oscillatory ventilator controlled trial. Ped Res 37: Abstract, Clark RH, Gerstmann DR, Null DM, et al. Highfrequency oscillatory ventilation reduces the incidence of severe chronic lung disease in respiratory distress syndrome. Am Rev Respir Dis 14:A687, Minton SD, Gerstmann DR, Stoddard RA. Ventilator strategies to interrupt pulmonary injury sequence. RT/The Journal for Respiratory Care Practicitioners Oct./Nov. 1992: HiFO Study Group. Randomized study of high frequency oscillatory ventilation in infants with severe respiratory distress syndrome. J Pediatr 122:609, Gerstmann DR, Minton SD, Stoddard RA. Pathophysiology of premature lung injury. Critical Care Review, SensorMedics Corp. PN , 1992.

9 ritical Care Review CURRENT APPLICATIONS AND ECONOMICS 9 10 Schwartz, RM, et al. Effect of surfactant on morbidity, mortality, and resource use in newborn infants weighing 500 to 1500 g. N Engl J Med 330: , Froese AB, McCulloch PR, Sugiura M, et al. Optimizing alveolar expansion prolongs the effectiveness of exogenous surfactant therapy in the adult rabbit. Am Rev Respir Dis 148:569, Jackson JC, et al. Reduction in lung injury after combined surfactant and high-frequency ventilation. Am J Respir Crit Care Med 150: , Matsuoka T, Kawano T, Miyasaka K. Role of high-frequency ventilation in surfactant-depleted lung injury as measured by granulocytes. J Appl Physiol 76: , Howell JDL, Solbert P, Proctor DF, Riley RL. Effect of inflation of the lung on different parts of the pulmonary vascular bed. J Appl Physiol 16:71, West JB, Dollery CT, Nacmacy A. Distribution of blood flow in isolated lung: relation to vascular and alveolar pressures. J Appl Physiol 19:713, Kinsella JP, Gerstmann DR, Clark RH, et al. High frequency oscillatory ventilation vs intermittent mechanical ventilation. Early hemodynamic effects in the premature baboon with hyaline membrane disease. Pediatr Res 29(2):160, Chang HK, Weber MI, King M. Mucus transport by high-frequency nonsymmetrical oscillatory airflow. J Appl Physiol 65:1203, Walker AM, Brodecky VA, de Preu ND, Ritchie BC. High-frequency oscillatory ventilation compared with conventional mechanical ventilation in newborn lambs: Effects of increasing airway pressures on intracranial pressures. Pediatr Pulmonol 12:11, HIFI Study Group. High-Frequency oscillatory ventilator compared with conventional mechanical ventilator in the treatment of respiratory failure in preterm infants. N Engl J Med 320:88, The HIFI Study Group. High-frequency oscillatory ventilation compared with conventional intermittent mechanical ventilation in the treatment of respiratory failure in preterm infants: Neurodevelopmental status at 16 to 24 months of postterm age. J Pediatr 117: , Klein JM, Patel CA. Decreased morbidity with high frequency ventilation in surfactant treated neonates with respiratory distress syndrome. Ped Res 33:Abstract 1292, Ogawa Y, Miasaka K, Kwano T, et al. A multicenter randomized trial of high frequency oscillatory ventilation compared with conventional ventilation in preterm infants with respiratory failure. Presented at the Seventh Conference on High Frequency Ventilation of Infants. Snowbird, Utah, April Gordon RW, Hoffmeister AC, Gladstone IM, et al. NICU's rate of Grade 3-4 intraventricular hemorrhage during two year HFOV experience compares favorably with the national incidence. Presented at the Eleventh Conference on High Frequency Ventilation of Infants, Snowbird, Utah, April Spitzer A. Presentation at the Eleventh Conference on High Frequency Ventilation of Infants, Snowbird, Utah, April 1994.

10 ritical Care Review CURRENT APPLICATIONS AND ECONOMICS 10 # Dale R. Gerstmann, MD Dr. Gerstmann is the Director of Neonatal Research and is staff Neonatologist at the newborn intensive care unit at Utah Valley Regional Medical Center in Provo, Utah. Stephen Minton, MD Dr. Minton is the Co-Director of Newborn Services at Utah Valley Regional Medical Center in Provo, Utah. He is an Adjunct Professor of Pediatrics at Weber State University in Ogden Utah. Ronald A. Stoddard, MD Dr. Stoddard is the Co-Director of Newborn Services at Utah Valley Regional Medical Center in Provo, Utah. He is an Adjunct Professor of Pediatrics at Weber State University in Ogden, Utah. SensorMedics Corporation Savi Ranch Parkway Yorba Linda, CA Telephone: (800) (714) Fax: (714) SensorMedics BV Rembrandtlaan 1b 3723 BG Bilthoven The Netherlands Telephone: (31) Fax: (31) P/N Copyright SensorMedics Corporation 1999

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