CORONARY: The Coronary Artery Bypass Grafting Surgery Off or On Pump Revascularization Study. Results at 1 Year
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1 CORONARY: The Coronary Artery Bypass Grafting Surgery Off or On Pump Revascularization Study Results at 1 Year André Lamy Population Health Research Institute Hamilton Health Sciences McMaster University Hamilton, CANADA on behalf of the CORONARY Investigators Disclosures: CORONARY was funded by a grant from the Canadian Institutes of Health Research (CIHR).
2 Background Benefits and risks of performing CABG surgery on beating heart (off pump) not clearly established. Meta-analyses of 59 trials involving 8961 pts No differences in major CV outcomes except strokes ROOBY (1 Year) Primary Outcome: Off-pump is worse (p=0.04) CV Deaths: Off-pump is worse (p=0.03) 2
3 CORONARY Trial Organization 79 centers in 19 countries 4,752 patients recruited between (November 2006 October 2011) Designed, coordinated, managed and data analysed and reported by the Population Health Research Institute, Hamilton Health Sciences and McMaster University in Hamilton, Canada The data was monitored by independent DSMB Funded by Canadian Institutes of Health Research 3
4 Inclusion/Exclusion Criteria Inclusion Criteria Isolated CABG with median sternotomy One of the following: 1. Peripheral vascular disease 2. Cerebrovascular disease 3. Renal Insufficiency 4. Age 70 years 5. Age with at least one risk factor (diabetes, urgent revascularization, smoker, LVEF 35%) 6. Age with at least two of the above risk factors Exclusions Additional cardiac procedure planned Contraindications to off-pump or on-pump CABG Emergency or re-do CABG 5
5 Qualifications of Surgeons Surgical expertise-based randomization > 2 years of experience as staff cardiac surgeon and > 100 cases of one or both techniques Trainees were not allowed to be primary operators 6
6 Primary Outcomes 1 st Co-Primary Outcome Composite of total mortality, stroke, non fatal myocardial infarction, new renal failure at 30 days post randomization results presented ACC 2012 results at 1 year 2 nd Co-Primary Outcome Composite of above outcomes plus repeat coronary revascularization over 5 yrs of follow-up (expected 2016) 7
7 Baseline Characteristics OFF-PUMP (n = 2375) ON-PUMP (n = 2377) Mean Age (years) Males (%) Prior MI Previous Stroke Peripheral Arterial Disease Congestive Heart Failure Urgent Surgery Euroscore >
8 Baseline Disease Pre-op Angiogram OFF-PUMP (n = 2375) % ON-PUMP (n = 2377) % Left Main Triple Vessel Double Vessel Single Vessel
9 1 st Co-Primary Outcome (1 Year) Off Pump % On Pump % Hazard Ratio 95% CI p value Primary Outcome Death, Stroke, MI, Renal Failure Components Death Stroke Non Fatal MI New Renal Failure
10 Cumulative Event Rate Death/MI/Stroke/New Renal Failure at 1 Year On Pump CABG Off Pump CABG HR % CI p value
11 Other Outcomes at 1 year Off Pump % On Pump % Hazard Ratio 95% CI p value Cardiovascular Mortality Angina PCI Re-do CABG PCI/Re-do CABG Primary Outcome per Protocol
12 Primary Outcome between 31 days and 1 Year Off Pump % On Pump % Hazard Ratio 95% CI p value Primary Outcome Death/MI/Stroke/Renal Failure Components Death Stroke Non Fatal MI New Renal Failure
13 Other Outcomes between 31 days and 1 Year Off Pump % On Pump % Hazard Ratio 95% CI p value Cardiovascular Mortality Angina PCI Re-do CABG < PCI/Re-do CABG
14 Quality of Life 19
15 Neurocognitive Function 20
16 Subgroups (1) 21
17 Subgroups (2) 22
18 Conclusions At 1 Year there was no difference between Off pump CABG and On pump CABG: Primary Outcome Individual components of the Primary Outcome Revascularization procedures Quality of Life Neurocognitive functions 23
19 Implications In experienced hands, both procedures are reasonable options based on mid-term results 24
20 Steering Committees A. Lamy (Co-PI) P.J. Devereaux J. Murkin D.P. Taggart D. Prabhakaran R.J. Novick A.R. Akar S.E. Fremes E. Paolasso A. Avezum S. Hu L. Piegas R. Cartier F. Lanas Z. Straka S. Chocron P.J. Lopez S. Yusuf (co-pi) 25
21 Final Recruitment by Country 4752 patients from 79 sites in 19 countries Canada (830) USA (68) Netherlands (27) Sweden (56) United Kingdom (227) France (4) Italy (48) Czech Republic (298) Estonia (91) Turkey (132) Ukraine (11) China (781) India (1307) Colombia (57) Brazil (358) Chile (137) Uruguay (34) Argentina (257) Australia (29) 26
22 27
Faculty/Presenter Disclosure
Faculty/Presenter Disclosure Faculty: Andre Lamy Relationships with commercial interests: Grants/Research Support: None Speakers Bureau/Honoraria: None Consulting Fees: None Other: None CORONARY: The Coronary
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