Calcium Removal and Plaque Modification in the Era of DEB and Contemporary Stenting for Femoro- Popliteal Disease
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1 Calcium Removal and Plaque Modification in the Era of DEB and Contemporary Stenting for Femoro- Popliteal Disease Thomas M. Shimshak, MD Heart and Vascular Center Florida Hospital Heartland Medical Center Sebring, FL
2 Disclosures Thomas M. Shimshak, MD I have the following potential conflicts of interest to declare: Consulting and Speaker Program Boston Scientific Corporation Research Boston Scientific Corporation, Volcano Corporation Teaching Programs Boston Scientific Corporation, Boston Scientific Corporation
3 Why is Plaque Modification Prior to DEB or Stenting Important? Plaque morphology in denovo lesions is complex Plaque burden is excessive and may limit stent expansion and effective drug delivery Debulking for ISR has been shown to be superior to angioplasty alone
4 Resistance to Balloon Dilation ΔVmax (µl) Why Should We Remove Calcium? Calcium is present in peripheral lesions 1 Presence of calcium necessitates greater balloon pressures 2,3 Plaques with associated calcium have increased dissection rates after angioplasty 5 Calcium may influence drug-coated balloon efficacy 4 and stent expansion Calcium Increases Arterial Resistance to Balloon Dilation 2 (Rabbit Model of Atherosclerosis) calcium/cholesterol cholesterol control 0 0 0,2 0,4 0,6 0,8 Calcium (mg/cm2 surface area) Artery Calcification 1. Bishop, et al. Ann Vasc Surg. 2008;22: Demer. Circulation. 1991;83: Makam. J Invasive Cardiol. 2013;25(2): Fanelli F, et al. Cardiovasc Intervent Radiol ;37(4): Fitzgerald, et al. Circulation. 1992;86(1):64-70.
5 Objective Evaluate the treatment effects of Jetstream in moderately to severely calcified peripheral artery disease Design Prospective, single arm, multicenter study Systematic use of IVUS analysis pre and post procedure Compare matched frames of IVUS images pre and post treatments with both quantitative and qualitative measurements IVUS, intravascular ultrasound; MI, myocardial infarction Maehara A, et al. EuroIntervention 2015; 19;11:
6 Inclusion Criteria Symptomatic lesions with superficial calcium > 90 and > 5 mm in length by IVUS Primary Endpoint Calcium removal and luminal gain as measured by IVUS from pre to post-jetstream treatment Maehara A, et al. EuroIntervention 2015; 19;11:
7 Currently Available JETSTREAM TM Systems Rotational/differential cutting tips Aspiration ports collect plaque & thrombus.014 GW / 7F sheath compatible XC 2.1/3.0mm SC 1.6mm XC 2.4/3.4 mm JETSTREAM XC (expandable Cutter) System 135 cm OTW Two sizing options in a single device SC 1.85mm JETSTREAM SC (Single Cutter) System 145cm OTW Single Cutter technology for tortuosity XC 2.1/3.0mm XC 2.4/3.4 mm SC 1.6mm SC 1.85mm
8 JETSTREAM Calcium Study Lesion Location and Characteristics Target lesion location Superficial femoral artery 62.5% 15/24 Popliteal artery 20.8% 5/24 SFA and Popliteal 12.5% 3/24 SFA and common femoral 4.2% 1/25
9 De novo lesions Angiographic calcium grade Lesion length (mm) Reference vessel diameter (mm) Adjunctive treatment JETSTREAM Calcium Study Lesion Characteristics Moderate 36.4% 8/22 Severe 63.6% 14/22 45 [20, 103] 5.0 [4.5, 5.9] Balloon angioplasty 61.5% 16/26 Stent 30.8% 8/26 Other atherectomy device 7.7% 2/26
10 JETSTREAM Calcium Study Lesion Characteristics Visual diameter stenosis (%) Pre-treatment 86 ± 9 (%) Atherectomy treatment time (mins) Post atherectomy 37 ± 13 (%) Post adjunctive treatment 10 ± 6 (%) Blades down 2.1 ± 1.0 Blades up 2.5 ± 1.8
11 JETSTREAM Calcium Removal Study Procedural and 30-Day Adverse Events Dissections 0 Perforation 0 Distal embolization 0 Major adverse events 0
12 Degrees Change in Lesion Dimensions Decrease of calcium (2.2 mm 2 ) accounted for 77% of luminal gain Increase in Lumen Area (mm 2 ) Maximum Arc of Reverberation P < p Pre Treatment Post Atherectomy 0 Pre Treatment Post Atherectomy
13 Change in Lesion Dimensions Post Atherectomy at Minimum Lumen Area Site The decrease in calcium area (2.8 mm 2 ) accounted for 86% of the lumen area increase Increase in Minimum Lumen Area (mm 2 ) Decrease in Area Stenosis (%) Pre Treatment p < Post Atherectomy Pre Treatment p < Post Atherectomy
14 Change in Lesion Dimensions at Maximum Calcium Ablation Site Increase in Lumen Area (mm 2 ) Decrease in Area Stenosis (%) p p Pre Treatment Post Atherectomy 0 Pre Treatment Post Atherectomy
15 JETSTREAM Calcium Removal Study Changes in MLA Post Atherectomy and Angioplasty Minimum Lumen Area (mm 2 ) 15 p < Post Atherectomy Post Angioplasty
16 IVUS Images From JETSTREAM Calcium Study Pre and Post JETSTREAM Atherectomy 3 mm 2 gain in lumen CSA with JETSTREAM Calcium reduction of 1.1mm 2 (37% of lumen gain) Maehara, A, et al. EuroIntervent 11(1),
17 JETSTREAM Atherectomy Angio and IVUS of Eccentric, Calcified CFA
18 JETSTREAM Atherectomy Angio and IVUS of Eccentric, Calcified CFA
19 Complex Rt CFA and Bifurcation Lesion Debulked with JETSTREAM Atherectomy : Pre Treatment Post Atherectomy and PTA
20 Left CFA Stenosis Baseline Angio and IVUS 2.4 mm 2 Lumen CSA EVT, Suppl. 2015
21 Post Jetstream Atherectomy Angio and IVUS 8.6 mm 2 Lumen CSA EVT, Suppl. 2015
22 Lessons from JETSTREAM Calcium Study Evaluation of the rotational atherectomy with dynamic aspiration system in femoro-popliteal stenoses with moderate to severe superficial calcification showed; The ability to accurately identify and localize superficial calcium was limited by angiography (only 50% in the study). There was a significant increase in lumen cross-sectional area that was further augmented by adjunctive balloon angioplasty. The removal and modification of superficial calcium accounted for a significant amount of the luminal gain in cross sectional area.
23 What are the implications of these results in the era of plaque modification and DEB and stenting? Pretreatment IVUS accurately characterizes plaque burden, morphology and detects the extent and location of superficial calcium. Plaque modification and calcium removal pre POBA, DEB and/or stenting (bare, DES, covered, bio-absorbable) may improve early and long term results by reducing the incidence of ballon induced dissection optimizing drug delivery of DEB Improving stent expansion, luminal gain, and drug delivery of stent platforms
24 Calcium Removal and Plaque Modification in the Era of DEB and Contemporary Stenting for Femoro- Popliteal Disease Thomas M. Shimshak, MD Heart and Vascular Center Florida Hospital Heartland Medical Center Sebring, FL
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