The Role of Mechanical Circulatory Support in Cardiogenic Shock: When to Utilize
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1 The Role of Mechanical Circulatory Support in Cardiogenic Shock: Presented by Nancy Scroggins ACNP, CNS-CC CV Surgery ACNP Bayshore Medical Center
2 The Role of Mechanical Circulatory Support in Cardiogenic Shock: Objectives Define Cardiogenic Shock Describe Goals of MCS Devices Currently Available Understand Indications, Contraindications & Complications
3 The Role of pmcs in Cardiogenic Shock: Cardiogenic Shock: Defined Systemic Tissue Hypo-perfusion Secondary to Inadequate Cardiac Output CI Decreased SVR Increased SVO2 Decreased PCWP Increased Tachycardia Hypotension MAP < 60mmHg Skin: cold, clammy, pale, moist Anxiety/Confusion Oliguria UO <30cc/H
4 The Role of pmcs in Cardiogenic Shock: Cardiogenic Shock: Defined Interagency Registry for Mechanical Assist Circulatory Support (INTERMACS) Defined 7 Clinical Profiles before Implantation of a Surgical VAD INTERMACS 1 & 2 Patients may be Considered for pvad as a Bridge to Recovery, Surgical MCS or Heart Transplantation Rihal et al. JACC (19) e7-e226.
5 The Role of pmcs in Cardiogenic Shock: INTERMACS Level Description Time to MCS 1 Crashing and burning - critical cardiogenic shock Within hours 2 Progressive decline inotrope dependence with continuing deterioration Within a few days 3 Stable but inotrope dependent describes clinical stability on mild-moderate doses of intravenous inotropes (patients stable on temporary circulatory support without inotropes are within this profile) Within a few weeks 4 Recurrent advanced heart failure recurrent rather than refractory Within weeks to months McLarty, A. Mechanical decompensation Circulatory Support and the Role of LVADs in Heart Failure Therapy. Clinical Cardiology 2015, 9:S2 5 Exertion intolerant describes patients who are comfortable at rest but are Variable intolerant of exercise 6 Exertion limited a patient who is able to do some mild activity but fatigue results within a few minutes or any meaningful physical exertion Variable 7 Advanced NYHA III describes patients who are clinically stable with a reasonable level of comfortable activity, despite history of previous decompensation that is not recent Not a candidate for MCS
6 The Role of pmcs in Cardiogenic Shock: Cardiogenic Shock: Defined Hours Days (INTERMACS) PROFILE 1: Critical cardiogenic shock - Patients with life threatening hypotension despite rapidly escalating inotropic support, critical organ hypoperfusion, often confirmed by worsening acidosis and/or lactate levels. PROFILE 2: Progressive decline - Patient with declining function despite intravenous inotropic support, may be manifest by worsening renal function, nutritional depletion, inability to restore volume balance Sliding on inotropes. Also describes declining status in patients unable to tolerate inotropic therapy. Rihal et al. JACC (19) e7-e226.
7 The Role of pmcs in Cardiogenic Shock: Indications Cardiogenic Shock AMI with related mechanical complications ADHF Acute mycarditis Post-cardiotomy shock Acute rejection post-cardiac transplant with hemodynamic compromise High-risk Interventions PCI Ventricular tachycardia ablation
8 MCS: Percutaneous Ventricular Assist Devices (pvad) Intra-Aortic Balloon Pump (IABP) LV support by LV pressure unloading Percutaneous Ventricular Assist Device (pvad) ventricular assist device LV support by LV volume unloading Impella Recover LP TandemHeart Gilotra and Stevens. Clinical Medicine Insights: Cardiology 2014; 8(S1):75-85.
9 MCS: Percutaneous Ventricular Assist Devices (pvad) Gilotra and Stevens. Clinical Medicine Insights: Cardiology 2014; 8(S1):75-85.
10 IABP Most Common 7.5 8Fr. Catheter 2 Lumens Inflation/Deflation Helium Low Viscosity Absorbed in Blood Rapidly Trigger EKG or Pressure Transduce Arterial Pressure Inflation Onset of LV Diastole Middle of T wave Deflation Onset of LV Systole Peak of R wave Gilotra and Stevens. Clinical Medicine Insights: Cardiology 2014; 8(S1):75-85.
11 IABP The Role of MCS in Cardiogenic Shock: Placement Descending Aorta Tip Distal Left Subclavian Artery Proximal to Renal Arteries Small Linear Metallic Marker
12 IABP The Role of MCS in Cardiogenic Shock: Placement Descending Aorta Tip Distal Left Subclavian Artery Proximal to Renal Arteries Small Linear Metallic Marker
13 IABP Hemodynamic Effects Increases (Augments) DBP Increases MAP Increases Coronary Perfusion Decreases Afterload (SVR) Decrease Myocardial Oxygen Consumption (Mv02) Modestly Improves CO Gilotra and Stevens. Clinical Medicine Insights: Cardiology 2014; 8(S1):75-85.
14 IABP Achieving Optimization Level of Intrinsic LV Function (CI ) Electrical Stability Tachycardia, AF Balloon Position Blood Displacement Volume Max Inflate Proper Timing Gilotra and Stevens. Clinical Medicine Insights: Cardiology 2014; 8(S1):75-85.
15 IABP Contraindications Moderate Aortic Regurgitation Severe PAD or Aortic Disease Aortic Dissection Aortic Aneurysm Prosthetic Aortic Grafts Local Sepsis CI < 1.2 or Refractory Tachyarrhythmias Severe Coagulopathy
16 IABP Complications Stroke Limb Ischemia Vascular Trauma Atheroembolism Thrombocytopenia Acute Kidney Injury Platelet deposition on balloon Use of Heparin (Variable) Infection Complications of Immobility
17 Impella 2.5 (12 Fr.) & 5.0 (21Fr.) Left Ventricle - Aorta Femoral Artery Insertion Flexible Pigtail Loop in LV Stabilizes in LV 2.5 Device Percutaneous Approach 5.0 Device Surgical Cutdown Decreases Likelihood Perforation Connects to Cannula that Contains Inlet (LV) Area Outlet (Aorta) Area Motor Housing Pump Pressure Monitor
18 Impella 2.5 (12 Fr.) & 5.0 (21Fr.) The Role of MCS in Cardiogenic Shock: Left Ventricle - Aorta Non-Pulsatile Axial Flow Screw Pump Blood LV to Ascending Aorta in Series Impella L/min CO Impella L/min CO
19
20 Impella Hemodynamic Effects LV & Pump Contribute to Flow Redirection From LV to Aorta Reduces LV Preload Reduces LV Filling Pressures Decreases Mv02 Increases BP & CO Reduction LV Wall Stress Unknown IV Heparin Can be used up to 7 days
21 Impella Contraindications Mechanical Aortic Valve LV Thrombus AS or AR (Relative) Severe PAD Severe Coagulapathies VSD Worsen Right to Left Shunting & Hypoxemia
22 Impella Complications Limb Ischemia Vascular Injury Bleeding Requiring Blood Transfusion Local Transfemoral Complications Hematoma Pseudoaneurysm Arterial Venous Fistula Retroperitoneal Hemorrhage Hemolysis Mechanical Shearing 5 10% of Patients within 1 st 24H Persistant Hemolysis with AKI Indication for Device Removal
23 Impella Complications Profound Coagulopathies HIT DIC History of HIT No Heparin Alternatives Bivalirudin or Argatroban
24 Tandem Heart Left Atrial - Aorta Percutaneous Insertion Centrifugal Pump Control Console Transeptal Cannula Large End Hole 14 Side Holes Arterial Perfusion Cannula Fr. 21 Fr. Transeptal Cannula - LA Femoral Arterial Cannulation Aspiration of Left Atrial Blood Determinant of Flow 3.5-5L/min
25 Tandem Heart Left Atrial - Aorta Centrifugal Blood Pump Centrifugal Pump 3,000 7,500 RPM IV Heparin Prevents Thrombus Formation Option to add Oxygenator LV Unloading & Oxygenation Can be Used for up to 14 Days
26 Tandem Heart Contraindications RV Failure or Insufficiency Normal RV Function - LA Filling Limited Use in VSD or Severe AR Severe PAD Profound Coagulopathies HIT DIC History of HIT No Heparin Alternatives Bivalirudin or Argatroban
27 Tandem Heart Hemodynamic Effects LV & Pump Contribute to Flow Redirection From LA to Aorta Reduces LV Preload Reduces LV Filling Pressures Reduces LV Wall Stress Decreases Mv02 Increases BP & CO Improves Perfusion Not Uncommon LV Contraction Ceases Systemic Perfusion becomes Pump Dependent
28 Tandem Heart Complications Vascular Trauma Limb Ischemia Transeptal Puncture Techniques Cariac Tamponade Thrombo or Air-Embolism Hemolysis Migration of LA Cannula PV Device Malfunction Dislodgement LA Cannula RA Severe Systemic Desaturation
29 In Summary
30 In Summary Device Selection Availability of Device Patient Anatomy, Level of Support Needed Operator Experience Comorbid Conditions Support Team Experience
31 Assessment Questions pmcs is indicated in patients with Cardiogenic Shock or High Risk PCI 1. True 2. False
32 Assessment Questions Which of the pvads provide the most hemodynamic support (CI) in patients with Cardiogenic Shock 1. IABP 2. Impella Tandem Heart
33 Thank You! Questions?
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