Quality Control of Herbal Products. Dr. Fabio Boylan

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1 Quality Control of Herbal Products

2 Quality Control of Herbal Products Known X Unknown Different strategies

3 Quality Control of Herbal Products Single X Multiple Different strategies

4 Quality Control of Herbal Products What are the strategies? Quality Control of the Complete Process From Plant Cultivation to the Elaboration of a Medicine

5 Quality Control of Herbal Products Following the Good Manufacturing Practice (GMP) Standards, perform the complete quality control taking into account: Pharmacognostic Methods Characteristic Fingerprint Chromatograms Defined amounts of Marker Substances Physicochemical Characteristics Microbiological Monitoring

6 Quality Control of Herbal Products Pharmacognostic Methods: Following all the tests written in official documents (Pharmacopoeias). Botanical QC (Macro X Micro) Chemical QC

7 Quality Control of Herbal Products

8 Quality Control of Herbal Products

9 Quality Control of Herbal Products

10 Quality Control of Herbal Products

11 Quality Control of Herbal Products

12 Quality Control of Herbal Products

13 Quality Control of Herbal Products

14 Quality Control of Herbal Products

15 Quality Control of Herbal Products Iberogast HPLC

16 Quality Control of Herbal Products

17 Quality Control of Herbal Products HPLC Fingerprint profile of two samples of the same herb from different habitats showing that plant taxonomical equivalence does not always mean: chemical equivalence. Pharmacological equivalence

18 Quality Control of Herbal Products TLC fluorescent images from two samples of Ginseng from different sources showing lack of standardisation for the ginsenosides profile. Sample B was not cultivated properly probably by using extra quantities of chemical fertilizer.

19 Quality Control of Herbal Products The new trend in modern phytotherapy is the use of standardized extracts. In this way, the importance of chromatographic techniques is huge. Application of Hyphenated Techniques

20 Quality Control of Herbal Products Application of Hyphenated Techniques HPLC-MS HPLC-NMR GC-MS HRGC-MS

21 Quality Control of Herbal Products However, Chinese Traditional Medicine still uses Herbs, specially mixture of herbs which makes things much more complicated. Introduction of Herbolome concept as oppose as Metabolome

22 Quality Control of Herbal Products Not only the QC of the preparations per se but also the pharmacological validation of them. Important to develop proper models for the evaluation of the proposed activities. Holistic information should be taken into account.

23 Quality Control of Herbal Products

24 Quality Control of Herbal Products

25 Quality Control of Herbal Products New perspectives for the success of phytotherapy by the use of omic-techniques. Genomics-Transcriptomics-Proteomics-Metabolomics Genetic map Expressed mrnas Proteins synthetised Secondary molecules synthetised

26 Quality Control of Herbal Products Quality Control of Herbal Material and Phytopharmaceuticals with MS and NMR Based Metabolic Fingerprinting

27 Cell Inclusions Potato Starch

28 Herbal Drugs used in the Practicals Senna SV

29 Herbal Drugs used in the Practicals Senna SV

30 Herbal Drugs used in the Practicals Senna Powder

31 Herbal Drugs used in the Practicals Senna Powder

32 Herbal Drugs used in the Practicals - Senna

33 Herbal Drugs used in the Practicals - Stramonium

34 Herbal Drugs used in the Practicals Celery TS

35 Herbal Drugs used in the Practicals Peppermint TS

36 Herbal Drugs used in the Practicals Peppermint TS

37 Herbal Drugs used in the Practicals Peppermint TS

38 Herbal Drugs used in the Practicals Peppermint TS

39 Herbal Drugs used in the Practicals Peppermint TS

40 Herbal Drugs used in the Practicals Cascara TS

41 Herbal Drugs used in the Practicals Cascara TS

42 Herbal Drugs used in the Practicals Cascara TS

43 Herbal Drugs used in the Practicals Cascara TS

44 Herbal Drugs used in the Practicals Licorice Powder

45 Herbal Drugs used in the Practicals Licorice Powder

46 Herbal Drugs used in the Practicals Licorice TS

47 Herbal Drugs used in the Practicals Licorice TS

48 Herbal Drugs used in the Practicals Licorice TS

49 Herbal Drugs used in the Practicals Licorice TS

50 Herbal Drugs used in the Practicals Licorice TS

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