Pharmacology. Drugs that Affect the Gastrointestinal System
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1 Pharmacology Drugs that Affect the Gastrointestinal System
2 Topics Peptic Ulcer Disease Constipation Diarrhea Emesis Digestion
3 Peptic Ulcer Disease Factors that Increase Acidity Factors that Protect Against Acidity
4 Peptic Ulcer Disease Factors Increasing H. H. pylori NSAIDs Acidic agents Pepsin Smoking Factors Decreasing Mucus production Buffers Blood flow Prostaglandins
5 Regulation of Gastric Acid Secretion
6 H 2 Receptor Antagonists Inhibits gastric acid secretion No effect on H 1 receptors cimetidine (Tagamet ) ranitidine (Zantac ) famotidine (Pepcid ) nizatidine (Axid )
7 H 2 Receptor Antagonists Indications: PUD GERD Prevention of of aspiration pneumonia
8 Proton Pump Inhibitors K + H + ATPase (Proton Pump) Irreversible inhibition Must synthesize new enzyme Long duration omeprazole (Prilosec ) lansoprazole (Prevacid )
9 Anticholinergics pirenzepine (Gastrozepine ) Other anticholinergics have too many side effects and are not used
10 Prostaglandin Analog misoprostol (Cytotec ) Approved for treating PUD due to to long term NSAID use
11 Antacids Increase ph of gastric environment Hydroxides Aluminum Magnesium Carbonates Calcium
12 Antacids Most OTC drugs are combinations DiGel Amphojel Maalox Milk of of Magnesia Mylanta
13 Antibiotics Aimed at eliminating H. pylori bismuth (Pepto-Bismol ) metronidazole (Flagyl ) amoxicillin (Amoxil ) tetracycline (Achromycin V )
14 Stool Formation Water absorbed in colon (~90%) Excessive absorption Constipation: hard, dehydrated stool Increases strain on on defecation Harmful for for subset of of patients Recent episiotomy, colostomy, hemorrhoids, cardiovascular disease Inadequate absorption Diarrhea: soft, non-formed, liquid stool
15 Terms Laxative Production of soft, formed stool over 1 or more days Cathartic Rapid, intense fluid evacuation of bowel.
16 Laxatives Bulk forming Surfactants Stimulants Osmotics
17 Bulk Forming Laxatives Absorb water Soften and enlarge stool Fecal swelling promotes peristalsis methylcellulose (Citrucel ) psyllium (Metamucil ) Polycarbophil
18 Surfanctant Laxatives Lowers surface tension Facilitates water penetration Docusate salts Colace Modane Soft ))
19 Stimulant Laxatives Stimulate peristalsis Increases water and electrolytes secretion into intestinal lumen Decreases water and electrolyte reabsorption Phenylolpthalein (Ex-Lax,, Feen-a- Mint,, Correctol )) bisacodyl (Ducolax )
20 Osmotic Laxatives Poorly absorbed salts remain in in fecal matter Pull water into lumen Magnesium hydroxid (Milk of of Magnesia )
21 Antidiarrheal Diarrhea is is usually a compensatory action Treatment aimed at at cause, no symptom Opioid receptors in GI tract decrease motility Increase time for water reabsorbtion
22 Antidiarrheal Agents paregoric/opium tincture diphenoxylate (Lomotil ) defenoxin (Motofen ) loperamide (Imodium )
23 Vomiting Stimulus
24 Antiemetics Serotonin (5HT) Antagonists Dopamine (DA) Antagonists Anticholinergics (muscarinic blockers) Cannabinoids
25 Serotonin Antagonists Used to treat side effects of chemotherapyinduced emesis condansetron (Zofran ) Doesn t affect dopamine receptors no extrapyramidal effects Granisetron (Kytril )
26 Dopamine Antagonists Phenothiazines prochloraperazine (Compazine ) promethazine (Phenergan ) Butyrophenones haloperidol (Haldol ) droperidol (Inapsine ) metoclopramide (Reglan )
27 Cannabinoids Tetrahydrocannabinol (THC) Active ingredient in in marijuana Dronabinol (Marinol ) Nabilone (Cesamet )
28 Digestion Aids Useful for inactive vagal stimulus/bypassed duodenum Pancreatin (Entozyme ) Pancrelipase (Viokase )
29 Thank You! To Temple College EMS Professions for permission to use their materials
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