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2 POT WEED CHRONIC GREEN KUSH BUD HERB WHAT MOTIVATES YOU TO USE POT?* AVOID USING CANNABIS RELAXES ME HELPS ME FIT IN HELPS ME FORGET MAKES ME FEEL HAPPY HELPS ME SLEEP CHANGES MY REALITY *Though there are many reasons to use pot, regular use can cause problems. PEOPLE WHO ARE AT HIGH RISK FOR CANNABIS USE-RELATED HEALTH PROBLEMS, SUCH AS THOSE YOUNGER THAN AGE 16 OR THOSE WITH PREVIOUS OR CURRENT MENTAL HEALTH ISSUES, SHOULD AVOID USING POT ALTOGETHER. THE CANADIAN PSYCHIATRIC ASSOCIATION CAUTIONS REGULAR USE BEFORE AGE 21. 1,2 WAIT UNTIL YOU RE OLDER BEFORE USING CANNABIS CANNABIS IN CANADA The legal age and location to purchase pot will be determined by each individual province. Visit Canada.ca to find out more. DON T BUY POT FROM THE STREETS You will require 1. Fischer B, et al. Lower-Risk Cannabis Use Guidelines: A Comprehensive Update of Evidence and Recommendations. Am J Public Health. 2017;107(8):e1-e Tibbo P, et al. Implications of Cannabis Legalization on Youth and Young Adults. Can J Psychiatry. 2018;63(1):65-71.

3 CHOOSE CANNABIS WITH LOWER THC LEVELS KNOW WHAT YOU ARE GETTING AVOID INHALING TOO DEEPLY CANNABIS CAN BE CONSUMED IN DIFFERENT FORMS DON T USE SYNTHETIC CANNABIS IF USING, CONSIDER NON-SMOKING METHODS O I L ASK ABOUT POTENCY gives you the high can have benefits Cannabis with high THC content can result in significantly worse mental health and cognitive outcomes 2 THC CDB Cannabidiol (CBD) is the main nonpsychotropic component in cannabis CBD is found to have a small, but significant relationship to self-reported positive symptoms. The therapeutic properties of CBD are reduced when the cannabis is smoked. 3,4 WHAT HAPPENS TO YOUR BRAIN? DON T DRIVE WHILE HIGH ATTENTION OVERALL I.Q. MEMORY PROCESSING SPEED MOTOR SKILLS Regular cannabis use in youth and young adults can affect aspects of cognition, including attention, memory, processing speed, motor skills and overall IQ Marco EM, et al. Endocannabinoid system and psychiatry: in search of a neurobiological basis for detrimental and potential therapeutic effects. Front Behav Neurosci. 2011;5: Schubart CD, et al. Cannabis with high cannabidiol content is associated with fewer psychotic experiences. Schizophr Res. 2011;130(1-3): Canadian Consortium for Early Intervention in Psychosis. Position Statement on Cannabis Legalization. Available at: Accessed January 18, 2018.

4 PSYCHOSIS AND REGULAR CANNABIS USE Rates of cannabis use are higher among people with schizophrenia than among the general population x People who use a lot regularly at an early age (16-18 years) or use high THC potency pot regularly are more likely to develop mental and social health issues. 1 RDON T USE CANNABIS EVE Y DAY CONVERSION TO SCHIZOPHRENIA AFTER A SUBSTANCE-INDUCED DIAGNOSIS Non-users PSYCHOTIC SYMPTOMS PSYCHOTIC NEVER USED CANNABIS SMOKE LESS THAN ONCE PER WEEK 7 SMOKE AT WEEKENDS SMOKE EVERYDAY Alcohol- Amphetamine- Cannabis- Almost half (46%) of all patients diagnosed with cannabis-induced psychosis have the potential to convert to a schizophrenia spectrum disorder. When looking at cannabis specifically, the majority of diagnosis conversions to a schizophrenia spectrum occurred during the first 3 years. 8 CANNABIS AND PSYCHOSIS CANNABIS USE WORSENS SYMPTOMS AND FUNCTION IN PATIENTS WITH SCHIZOPHRENIA 9 PANSS Scores Used and stopped Continued Use Never used Baseline 1 Year 3 Years 5 Years **The PANSS Scale is used to measure severity of psychotic symptoms Continued cannabis use worsens long term symptom and functional outcomes, greater severity of symptoms, a higher risk of relapse, reductions in medication adherence, and global functioning deficits. 6. Arseneault L, et al. Causal association between cannabis and psychosis: examination of the evidence. Br J Psychiatry. 2004;184: Forti MD, et al. Proportion of patients in south London with first-episode psychosis attributable to use of high potency cannabis: a case-control study. The Lancet Psychiatry. 2015;2(3): Niemi-Pynttäri JA, et al. Substance-induced psychoses converting into schizophrenia: a register-based study of 18,478 Finnish inpatient cases. J Clin Psychiatry. 2013;74(1):e González-Pinto A, et al. Cannabis and first-episode psychosis: different long-term outcomes depending on continued or discontinued use. Schizophr Bull. 2011;37(3):

5 CANNABIS: KEEP THIS IN MIND THC CDB Fischer B, et al. Lower-Risk Cannabis Use Guidelines: A Comprehensive Update of Evidence and Recommendations. Am J Public Health. 2017;107(8):e1-e12. Support for this tool provided by Otsuka-Lundbeck Alliance

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