PROCTO - CLINICAL STUDIES.

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1 PROCTO - CLINICAL STUDIES

2 THE USE OF THE HERBAL PREPARATION BENOSTAN PROCTO IN INFLAMMATORY DISEASES OF THE ANUS Dr A. TSATALI, Dr P. IOANNIDOU, Dr P. APOSTOLOPOULOS, Dr TH. ARNAOUTI, Dr E. VAFEIADI-ZOUMPOULI A Propaedeutic Clinic of Internal Medicine, University of Athens General Hospital of Athens LAIKO

3 PURPOSE The evaluation of the localized effect of the herbal preparation BENOSTAN PROCTO in patients suffering from proctitis or/and hemorrhoids.

4 PATIENTS AND METHODS 27 patients (8 men and 19 women) with clinical symptoms of proctitis and/or hemorrhoids were examined. The findings were confirmed endoscopically by rectoscopy, after the exclusion of other inflammatory diseases of the large intestine. The patients were advised to wash systematically the area and they received proper diet recommendations and a prescription of the topical cream BENOSTAN PROCTO twice a day for two to four weeks.

5 COMPOSITION OF BENOSTAN PROCTO OLEUM HYPERICI OLIUM OLIVARUM BEESWAX STEARIC ACID STEARYL ALCOHOL TRIETHANOLAMINE GLYCEROL IMIDAZILIDINYL UREA GUM MASTIC WATER SODIUM STEARYL SULFATE

6 ENDOSCOPIC FINDINGS MEN WOMEN Proctitis st degree hemorrhoids nd degree hemorrhoids 2 5 All patients underwent re-examination during the third or fourth week. EVALUATION: The regression of clinical symptoms (pain - bleeding) and the local inflammatory effects (edema, hyperemia, bleeding).

7 RESULTS The rectoscopy showed: proctitis in 25 patients, 1st degree hemorrhoids in 22 and 2nd degree hemorrhoids in 7 patients. The effect of the drug was assessed on a scale of three grades: complete regression (+), improvement (+), failure (-). BEFORE AFTER Symptoms - Findings Pain Bleeding Edema Hyperemia

8 CONCLUSION The topical use of the herbal preparation BENOSTAN PROCTO is well-tolerated and highly effective in treating proctitis and hemorrhoids of 1st - 2nd degree.

9 BEFORE AFTER 4 WEEKS

10 BRIEF INFORMATIVE REPORT A plant originated product in cream for the topical treatment - cure of hemorrhoids. The problem of hemorrhoids has become important and quite often nowadays, due to the present lifestyle. It mainly appears on women during pregnacy, after childbirth, but also on men due to bad nutritional habits, stress, profession etc. COMPOSITION: Virgin olive oil, natural bees wax, St. John s Wart extract and natural perfume. ACTIVE INGREDIENTS: Catachines: (catechine epicatechine): anti-swelling action. Flavonoidic glucosides: (routoside, hiperoside, quersetin): they strengthen the inner walls of the capillaries, they present anti-swelling action and exert a vitamin P action. Tannines: astringent, anti-inflammatory, flebocontractive, haemostatic action. Vitamins C & P: protective effect on the capillaries inner walls, reduction of the capillaries diameter. Vitamin E (tocopherol): protective effect on the epidermis due to its anti-ossidative, anti free - radical properties. Linelaic acid: remodeling effect on the skin s tissues. Carotenoides: healing effect on the skin tissues. PREVENTION AND CURE ON THE HEMORRHOIDS PATHOLOGY Significant protective action of the capillaries. Improvement of capillary circulation. Prevention of edemas and draying of the already existing. Fleboconstraction due to vitamin P. Anti-inflammatory action on the anus area. Epithelization, healing of the damaged tissues. Anti-hemorrhagic action. INDICATIONS: Internal and external hemorrhoids. Proctitis, hemorrhage, anal fissures (complications of hemorrhoids). Post - operative treatment. Hemorrhoidal situation after childbirth. IT IS USED FOR: Increasing the tone of the vein s walls. Supporting the vein circulation. Provoking epithelization and thus healing the anal damaged epithelium. Preventing edemas (swelling) and provoking draining of the already existing.

11 BRIEF INFORMATIVE REPORT CLINICAL APPLICATIONS: It is used with immediate and excellent results in all cases of hemorrhoids. In anal fissures. In pregnancy, where hemorrhoids appear very often. After the childbirth, when almost all women suffer from hemorrhoids, due to the pressure during labor. That is why women have a great pain in the area. In this case, results are immediate and spectacular. The day after using BENOSTAN PROCTO they felt already comfortable and before getting out of the clinic, the whole area that was swelled and edematic before using BENOSTAN PROCTO, had already returned to the normal condition. After the surgery of hemorrhoids or the laser treatment where the whole area is inflammated and swelled, clinical applications have shown that BENOSTAN PROCTO, in spite of the fact that it is a 100% plant originated product, it has a stronger anti-inflammatory action that corticosteroids. In hemorrhoids of the anus from hemorrhoids, it has excellent results, due to its topical astringent effect. METHOD OF USAGE: The product is applied on the suffering area, which has to be dry, after a thorough cleansing. In case of difficulty, there can be used the special nozzle, so that the application of the product is properly used. BENOSTAN PROCTO cream does not contain corticosteroids or topical anesthetics and that s why it can be used repeatedly without any restriction. In conclusion, the plant originated product BENOSTAN PROCTO can be used for the topical cure and that s why it can be used repeatedly without any restriction. In conclusion, the plant originated product BENOSTAN PROCTO can be used for the topical treatment of hemorrhoids from women during or after pregnancy, from persons, men or women who have been operated for anal fissures and/or hemorrhoids. People who suffer from proctitis or hemorrhages can also use it.

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