Medical Cannabis Then and Now. Jeffrey Skell, PhD
|
|
- Frank McCoy
- 5 years ago
- Views:
Transcription
1 Medical Cannabis Then and Now Jeffrey Skell, PhD 2016
2 Agenda A Brief History of Cannabis Drug Properties Is Cannabis Developable?
3 The Source of All That Trouble
4 Traditional Medicine in the Far East and Subcontinent Indica Body High Analgesic Muscle Relaxant Sedating Sativa Cerebral High Stimulating Anti-depressant Increase Appetite Hemp High in CBD Low in THC Muscle Relaxant Analgesic Diverse preparation methods were known Adopted by western culture up until the 30 s Currently Schedule I in the USA
5
6 State Based Legalization Mid-90 s ballot initiatives covering medical Established growers transitioning from black to gray market, paying taxes Recreational use in 4 states and DC Cole memo: August 29, 2013 DOJ issued guidance covering federal departmental policy regarding state sanctioned activities Eric Holder Says DOJ Will Let Washington, Colorado Marijuana Laws Go Into Effect 08/29/2013
7 What Does That Mean Each state writes their own laws regulating growers, manufacturers, dispensaries, testing labs, distributors, packaging and labeling, and on and on No interstate transport except between adjoining states with reciprocity Widely different regulations, acceptable products and practices between states
8 Types of Cannabinoids Synthetic (synthetic phytocannabinoids) Marinol Synthetic delta 9-THC Approved by FDA in 1985 for nausea/vomiting from chemotherapy Approved by FDA in 1992 for AIDS related anorexia Endocannabinoids (naturally occurring in humans) Neuromodulatory lipids and receptors (CB1 &CB2) Variety of compounds and inhibitors with serious effects Recent phase one trial death in France- fatty acid amide hydrolase (FAAH) inhibitor (enzyme produced in the brain and elsewhere in the body that breaks down neurotransmitters known as endocannabinoids) Number of companies working on endocannabinoids, inhibitors and similar compounds to bind to receptors
9 Types of Cannabinoids Phytocannabinoids- >66 known naturally occurring compounds in plants that effect the endocannabinoid system, some of the more known or medically studied, (many found in acid form as well before drying) THC (tetrahydrocannabinol)- Psychotropic. Analgesic (pain relieving). Appetite stimulant. Bronchial dilator CBD (Cannabidiol)- Non-psychoactive. Reduces muscle spasms. Muscle relaxant. Analgesic (pain relieving) CBN (Cannabinol)- Mildly psychoactive. Non-narcotic analgesic (pain relieving) THCV (Tetrahydrocannabivarin)- Stronger, faster high effect. Appetite suppressant. Euphoria, analgesic CBC (Cannabichromene)- Sedative effect. Moderates effects of THC. Analgesic CBG (Cannabigerol)- Non-psychoactive, sleep inducing. Anti-microbial. Lowers intra-ocular pressure (IOP)
10 Chemical Structure THCA is the Naturally Occurring Form Combustion Heat vaporizes remaining THC OH
11 At Least 50% is Pyrolyzed CO2, CO, benzene, tar, free-radicals THC, CBN, others THC-A
12 Modes of Administration Inhalation Cigarette Pipe Water pipe Vaporizer Dab DPI Oral and Cutaneous Edible (foods, beverages, candies) Tincture (usually alcohol based) Sublingual (sprays, tablets) Tablet/capsule (less popular?) Local/Topical (creams, ointments) Transdermal (patches)
13 Excipients Use in Cannabinoid Delivery Excipients aid delivery and form in most available delivery platforms They play typical roles as in conventional industry Fillers, carriers and lubricants antioxidants and preservatives Viscosity modification Humectants Co-solvents penetration enhancers Bioavailability enhancement Big opportunity just like conventional pharma
14 Excipients Use in Cannabinoid Delivery PEG PEG 400 most popular grade Glycerin Used like PEG Alcohol - used in tinctures Solubilizes of cannabinoids Solid Dose Excipients MCC carrier of concentrate oil for tablets and capsules Sugars and combinations also used as carriers Gelatin gummy based edibles Topicals and Transdermals Cetyl alcohol, natural waxes, adhesives United States Cannabis market is estimated at over $700 million/yr soon to pass $1 billion/yr
15 Physico-Chemical Properties MW BP 315ºF (with decomposition) Log P > 4 (closer to 6) Water insoluble Soluble in oils, dehydrated alcohol, organic solvents, supercritical CO2 Doesn t fit the classic drug discovery criteria
16 DMPK Properties Inhalation BA 10-35% Oral BA 6-20% (highly variable) PPB >95% Significant 1 st pass metabolism to a different metabolite than inhalation Partitions into fat and skin; very slow and variable wash out time
17 Onset Depends on Route of Administration Pharmacokinetics Smoking BA is <50% (typically 10%-35%) Oral BA is <20%, highly variableand effect may last a long time
18 It Isn t All About THC Taming THC: potential cannabis synergy and phytocannabinoidterpenoid entourage effects Cannabis terpenoids: limonene, myrcene, a-pinene, linalool, b- caryophyllene, caryophyllene oxide, nerolidol and phytol. Synergy with respect to treatment of pain, inflammation, depression, anxiety, addiction, epilepsy, cancer, fungal and bacterial infections Ethan B Russo Ethan B Russo, GW Pharmaceuticals, Salisbury, Wiltshire, UK 1344 British Journal of Pharmacology (2011)
19 It Isn t All About THC Currently GW drug Epidiolex (>98% CBD, no THC) is achieving success in clinical trials for Dravet syndrome and Lennox-Gastaut syndrome (judged by reduction of epileptic siezures) High CBD strains of cannabis (most notable, charlotte s web ) have been used successfully in underground treatment for years to treat drug resistant epilepsy in children
20 Whole Plant Composition Cannabis Plant Material Sesquiterpenes Terpenes Cannabinoids Flavonoids Pigments Sugars Chlorophyll Fats Waxes Lignin Pectins Starches Cellulose *Lipids
21 What is the API Form? Dried flower 10-25% Keif/Hashish/Rosin Low potency infusions % High potency concentrates 60-95% Areas for Concern: CU, composition, pesticides, metals, residual solvents, unknown impurities, batch-batch variability
22 Dried Flower Strain: highly inbred and crossed Grow technique: indoor/outdoor, nutrients Plant to plant Bud to bud Sample size for testing Physical stability, packaging Only a fraction of the total plant material
23 High-Potency Concentrates Extraction technology has evolved, but it is not regulated by anything resembling FDA Distillation produces 95% pure THC where did the other go? Isolation of purified fractions is expensive Synthetic or natural terpene additives expensive, and stability is not monitored Branding: product in NY same as LA
24 We Need a Pharmacopoeia American Herbal Pharmacopoeia issued 1 st of a 2 part series in 2013 Schedule I complicates clinical studies Well controlled drug substance and drug product is required for clinical studies Regulatory oversight: ATF, FDA, DOJ Unified structure for medical, recreational, and care giver marketplace
25 Credits and Acknowledgements MCR Labs Skell Labs David Schaible Excipient Fest
(THC) Delta9-tetrahydrocannabinol:
(THC) Delta9-tetrahydrocannabinol: Most prominent compound found in the cannabis plant found in the 1960 s. THC binds to the CB1 and CB2 receptors causing a change in the function of the cell it is binding.
More informationSusan Audino, PhD S.A. Audino & Associates, LLC
Cachexia, Cancer, Chronic Pain, Epilepsy, Glaucoma, HIV, AIDS, Multiple Sclerosis, Nausea, ALS, Crohn s, Hepatitis C, Anorexia, Arthritis, Migraine, Parkinson s, Damage to the Nervous Tissue of the Spinal
More informationCannabis and the Endocannabinoid System
Cannabis and the Endocannabinoid System September 7, 2018 Bangkok, Thailand David Bearman, MD Goleta, California Executive VP, American Academy of Cannabinoid Medicine AACMSITE.org Shen Nung Ping
More informationMedical Cannabis MATT WEBSTER DO, MS
Medical Cannabis MATT WEBSTER DO, MS Cannabis Sativa One of the oldest used drugs and medicinal remedies Most commonly abused illicit drug in the US There has been increasing access for medicinal MJ use
More informationMedicinal Cannabis Dosage Forms in California
Mica Gross President Sante Botanica / COO MDBioLogics Medicinal Cannabis Dosage Forms in California An Overview of Cannabis Dosage Forms Forms of dosage are the specific vehicles by which cannabis, or
More informationCannabinoids. Effects of Cannabis
Cannabis is a flowering plant that has fibrous stalks used for paper, clothing, rope, and building materials; leaves, flowers, and roots used for medicinal purposes; and seeds used for food and fuel oil.
More informationTrichomes: Crystalline structures that coat parts of the cannabis plant that hold the majority of the cannabinoid content.
ESSENTIAL MARIJUANA TERMS To more fully understand marijuana, you have to know the language of marijuana. Marijuana has its own language. That s due in part to the complexity of marijuana as a plant, and
More informationCannabis: Ancient Medicine, Modern Marvel Jessica Baker, LAc, RH (AHG)
AHG Advanced Webinar Intensives Presents: Cannabis: Ancient Medicine, Modern Marvel Jessica Baker, LAc, RH (AHG) Hosted by Michele Marlow The American Herbalists Guild promotes clinical herbalism as a
More informationADVANCED CLINICAL CANNABINOID PROVIDER EXAM ACCP
ADVANCED CLINICAL CANNABINOID PROVIDER EXAM ACCP Page 1 1. In what year did the possession and transfer of cannabis for recreational use become illegal in the United States? A. 1937 B. 1941 C. 1933 2.
More informationIntroduction to Medical Cannabis
Introduction to Medical Cannabis A brief history of Cannabis The healing properties of cannabis have been known for quite some time. References to cannabis, and its therapeutic use, date back ancient China,
More informationCannabis. Member of the Cannabaceae family of flowering plants (along with hops) Cannabis sativa (v. sativa, indica, afghanica, ruderalis)
Member of the Cannabaceae family of flowering plants (along with hops) sativa (v. sativa, indica, afghanica, ruderalis) Only females flowers contain high concentrations of psychoactive oils (cannabinoids)
More informationFederal Law: Marijuana
Federal Law: Marijuana Marijuana is a Schedule I drug under Federal Controlled Substances Act Makes possession, usage, purchase, sale, and/or cultivation of marijuana illegal at the federal level May not
More informationMedical Marijuana. Navigating Medical Marijuana in Workers Compensation
Medical Marijuana Navigating Medical Marijuana in Workers Compensation Agenda Federal and State Laws Public Health Adverse Effects & Concerns Clinical Use Implications for Employers Implications for Workers
More informationMedical Marijuana. 1. is a plant species, variety known as hemp. 3. Tetrahydrocannabinol is an aromatic with low water solubility.
Medical Marijuana Questions from Part 1: 1. is a plant species, variety known as hemp. a. Cannabis sativa Linnaeus b. Cannabis sativa c. Cannabis indica d. Cannabis Lemark 2. The major psychoactive compound
More informationWeeding Through the Science of Cannabis. Ryan Vandrey, PhD
Weeding Through the Science of Cannabis Ryan Vandrey, PhD What is Cannabis? Basic Plant Information Cannabis is a genus of plants with 3 species: Cannabis Sativa Cannabis Indica Cannabis Ruderalis Plant
More informationExtraction News Notes Blog
Extraction News Notes Blog www.infinitysupercritical.com BY: Infinity Supercritical Staff EG TAGS: Supercritical CO2 Oil Extraction, Cannabis, Oil Concentrates Sustainable Production of Cannabinoids with
More informationCBD OIL BUYER S GUIDE
CBD OIL BUYER S GUIDE CBD OIL CBD (cannabidiol) oil has become incredibly popular for pets and with good reason. Dog owners are finding it helps their dogs with a number of different health issues. It
More informationThe Scientific Side of Medical Marijuana
The Scientific Side of Medical Marijuana Ken Mackie, MD Indiana University Bloomington, IN December 3, 2009 kmackie@indiana.edu Financial disclosures NIH (NIDA) - research grants Alzheimer s Association
More informationThe Shifting Federal Regulation of Cannabis Products
The Durham Bar 2019 CLE Program The Shifting Federal Regulation of Cannabis Products Erica M. Jackson, FDA Partner K&L Gates February 6, 2019 Copyright 2018 by K&L Gates LLP. All rights reserved. OVERVIEW
More informationACS. Quality, Integrity, Safety. Our logo says it all
ACS Quality, Integrity, Safety Our logo says it all Welcome to Alternative Compassion Services We are happy you have chosen us to assist you in improving your health with the use of Medical Marijuana.
More informationUltimate Guide: Everything You Need To Know Before Buying CBD Hemp Oil
Ultimate Guide: Everything You Need To Know Before Buying CBD Hemp Oil Cannabidiol (CBD) is taking the health and wellness community by storm. Between news coverage and personal testimonies, it is a highly
More informationMEDICAL CANNABIS IN MINNESOTA
MEDICAL CANNABIS IN MINNESOTA EPILEPSY & SEIZURES WELLNESS EXPO APRIL 16, 2016 MICHELLE LARSON, MPA MDH OFFICE OF MEDICAL CANNABIS 2014: Minnesota becomes 22 nd state with a medical cannabis program State
More informationMedical Cannabis use in the Older Patient
Medical Cannabis use in the Older Patient Dr. Amanjot Sidhu Division of Geriatric Medicine McMaster University Audience Poll What is the fastest-growing demographic of cannabis users? a) Ages 14-23 b)
More informationMEDICAL CANNABIS IN MINNESOTA
MEDICAL CANNABIS IN MINNESOTA MINNESOTA ACADEMY OF PHYSICIAN ASSISTANTS MARCH 18, 2016 TOM ARNESON, MD, MPH MDH OFFICE OF MEDICAL CANNABIS 2014: Minnesota becomes 22 nd state with a medical cannabis program
More informationDetermination of Cannabinoid and Terpene Profiles in Cannabis Oils by Mid-Infrared Spectroscopy: 1. Cannabinoids
1 Brian C. Smith, Ph.D., Big Sur Scientific, brian@bigsurscientific.com, (508) 579-6514. Determination of Cannabinoid and Terpene Profiles in Cannabis Oils by Mid-Infrared Spectroscopy: 1. Cannabinoids
More informationCannabis for RDNs (Who Don t Know their CBD from their THC!)
Cannabis for RDNs (Who Don t Know their CBD from their THC!) Janice Newell Bissex, MS, RDN Holistic Cannabis Practitioner Today s Talk What is cannabis? History of use Components of cannabis Condi@ons
More informationMD GUIDE TO USING MEDICAL CANNABIS
Natural Remedy MD GUIDE TO USING MEDICAL CANNABIS The leaves and flowers of the Cannabis plant are consumed in several forms: dried flower buds or various types of concentrated, loose, or pressed resin
More informationA look at Marijuana in 2014
A look at Marijuana in 2014 Paul Snyder MA., LADC Overview and Objectives Discuss the mental and physical effects of marijuana use Describe the criteria for Cannabis use disorder according to the DSM 5
More informationGlobal Legal Cannabis Market: Size, Trends & Forecasts ( ) September 2018
Global Legal Cannabis Market: Size, Trends & Forecasts (2018-2022) September 2018 Global Legal Cannabis Market: Coverage Executive Summary and Scope Introduction/Market Overview Global Market Analysis
More informationVisit: NEHA s Online Cannabis Resources
Visit: NEHA s Online Cannabis Resources Purpose The purpose of this glossary is to provide a compilation of common terms and concepts related to the cannabis and cannabis-infused food products industry.
More informationProduct Catalogue MAY 2017
Product Catalogue MAY 2017 Green Island Naturals combines science with an intimate knowledge of plant based medicines to build on healing traditions started by our ancestors long ago. Science, in the
More informationBeginner s Guide to CBD OIL
Beginner s Guide to CBD OIL What is CBD? In recent years, CBD oil has skyrocketed in popularity, but it also has raised concerns and controversy usually due to a misunderstanding of what CBD is all about.
More informationMedical Cannabis use in the Older Patient. Amanjot Sidhu, MD, FRCPC Division of Geriatric Medicine McMaster University
Medical Cannabis use in the Older Patient Amanjot Sidhu, MD, FRCPC Division of Geriatric Medicine McMaster University Disclosure Relationships with commercial interests: Grants/Research Support: none Speakers
More informationThe Return of Medicinal Cannabis
The Return of Medicinal Cannabis George Kolodner, M.D. DLFAPA FASAM Chief Clinical Officer Clinical Professor of Psychiatry Georgetown University School of Medicine University of Maryland School of Medicine
More informationThe products being taken by children with epilepsy are not the equivalent of the marijuana widely used for recreational purposes.
Epilepsy Foundation of Colorado The Use of Cannabis to Treat Children with Epilepsy Updated February 2016 The use of extracts from marijuana plants (cannabis) to treat children with epilepsy has been in
More informationCannabis 101 Safe, Versatile & Effective
Cannabis 101 Safe, Versatile & Effective Cannabis is a treasure trove of healing. Dr. Raphael Mechoulam, He is the father of cannabis science is an organic chemist and professor of Medical Chemistry, at
More informationExtraction, Isolation and Analysis of Cannabis Extract and Preparation
Extraction, Isolation and Analysis of Cannabis Extract and Preparation A S S O C.PROF. D R. N A R I SA K A M K AEN D I R EC TO R O F H E R BAL P H A R MACY C O L L EG E O F P H A R MACY, R A N G S I T
More informationResponsibility through testing THE HANDBOOK. Understanding Your Laboratory
Responsibility through testing THE HANDBOOK Understanding Your Laboratory Table of Contents Page3...Welcome Page 4...Submitting Samples Page 5...Setting the Standard Page 6...Top 10 Questions Page 7...Cannabinoid
More informationAGENDA. 9:00 Sign-in and introductions 9:15 Marijuana 10:30 Break 10:45 Opioid Prevention 11:30 Discussion & Wrap-Up
AGENDA 9:00 Sign-in and introductions 9:15 Marijuana 10:30 Break 10:45 Opioid Prevention 11:30 Discussion & Wrap-Up Marijuana: Preventing Youth Use Juliet D Alessandro, Healthy Communities Specialist Today
More informationCannabis & Hemp therapeutic solutions
Cannabis & Hemp therapeutic solutions with Our Cannabis & Hemp quality standards Thanks to their rich characterization and proprietary extraction method, our therapeutic solutions are a reference point
More informationCannabis 101 Safe, Versatile & Effective Medicine
Cannabis 101 Safe, Versatile & Effective Medicine Cannabis is a treasure trove of healing. Dr. Raphael Mechoulam, the father of cannabis science is an organic chemist and professor of Medical Chemistry,
More informationOXZGEN FAQ s What is the Endocannabinoid System? What are cannabinoids? What is CBD oil?
OXZGEN FAQ s What is the Endocannabinoid System? Discovered only a few decades ago, the endocannabinoid system (ECS) is one of the most important physiological systems in our body. It consists of a group
More informationCannabis in the treatment of Autism:
Cannabis in the treatment of Autism: Are we ready? Deb Karhson, PhD and Lawrence Fung, MD, PhD Cannabis Anecdotal Data: Comparing Epilepsy and Autism+ Science of Cannabinoids: Endocannabinoid System Receptor
More informationCannabidiol as a potential treatment for anxiety disorders. Esther Blessing, MD PhD
Cannabidiol as a potential treatment for anxiety disorders Esther Blessing, MD PhD Overview History and of cannabidiol (CBD) and cannabis Safety and tolerability of CBD CBD pharmacology Clinical need for
More informationUnderstanding Hemp Extracts and CBD Oil. Quality assurance, product selection, and serving size tracking.
Understanding Hemp Extracts and CBD Oil. Quality assurance, product selection, and serving size tracking. When selecting cannabis products, quality is the highest priority. Regulations in the hemp industry
More informationResearch on Cannabis and PD: Is there any evidence?
Research on Cannabis and PD: Is there any evidence? Benzi M. Kluger, MD, MS Associate Professor of Neurology and Psychiatry Director Movement Disorders Center University of Colorado Denver DISCLOSURES
More informationPennsylvania House of Representatives. Joint Health and Judiciary Committee Hearing. Medical Cannabis - Health Care Forum
Pennsylvania House of Representatives Joint Health and Judiciary Committee Hearing Medical Cannabis - Health Care Forum Tuesday, March 24, 2015 Philadelphia, Pennsylvania Testimony offered by: David J.
More informationGetting Into the Weed: Potentials and Pitfalls Affecting Medical Use
Getting Into the Weed: Potentials and Pitfalls Affecting Medical Use Cydney E. McQueen, PharmD Clinical Associate Professor UMKC School of Pharmacy Objectives Describe in simple terms the endocannabinoid
More informationPAST, PRESENT AND FUTURE OF MEDICAL CANNABIS
PAST, PRESENT AND FUTURE OF MEDICAL CANNABIS Asare B. Christian, MD, MPH Associate Outpatient Medical Director, Good Shepherd Rehabilitation Network Clinical Faculty, Penn Medicine Outline Medical History
More informationQ's &A's of Medical Cannabis in Illinois
WHAT IS CANNABIS? Cannabis, also known as marijuana, is a dynamic plant that has medicinal and therapeutic benefits. Chemical compounds in the plant are called cannabinoids and terpenes work together to
More informationCBD Oil: Benefits, Top Products, Where To Buy, And More
CBD Oil: Benefits, Top Products, Where To Buy, And More CBD hemp oil has a huge range of potential health benefits and uses, including reducing pain, soothing anxiety, fighting cancer, improving mood,
More informationOutcome. Educating Ohio Providers On The Basics Related To Recommending Medical Marijuana. Connie J. Cerilli, APRN, FNP-C
Educating Ohio Providers On The Basics Related To Recommending Medical Marijuana Connie J. Cerilli, APRN, FNP-C Outcome Participants will be able to list 3 approved medical conditions Participants will
More informationEducating Ohio Providers On The Basics Related To Recommending Medical Marijuana. Connie J. Cerilli, APRN, FNP-C
Educating Ohio Providers On The Basics Related To Recommending Medical Marijuana Connie J. Cerilli, APRN, FNP-C Outcome Participants will be able to list 3 approved medical conditions Participants will
More informationI would like to begin by acknowledging that we are on the ancestral grounds of the Beothuk people
I would like to begin by acknowledging that we are on the ancestral grounds of the Beothuk people Introduction to the Cannabinoid System And Medical Use Dr Alia Norman Radiation Oncologist Cannabinoid
More informationSUPER SNOUTS CBD150 & CBD300 OIL FOR DOGS & CATS
SUPER SNOUTS CBD150 & CBD300 OIL FOR DOGS & CATS Why choose Super Snouts CBD Oils? Super Snouts has an outstanding reputation for creating well researched, effective and affordable health supplements for
More informationThe Sale of Cannabis in Pharmacies. Michael H. Ghobrial, PharmD, JD Associate Director, Health Policy American Pharmacists Association
The Sale of Cannabis in Pharmacies Michael H. Ghobrial, PharmD, JD Associate Director, Health Policy American Pharmacists Association Development This activity was developed by the American Pharmacists
More informationMedical Cannabis and OMT
Medical Cannabis and OMT David R. Beatty, DO Professor of Osteopathic Principles and Practice, WVSOM November 4, 2017 Objectives At the completion of this presentation the attendee should be able to: 1.
More informationCBD USER GUIDE CUREDNUTRITION.COM CBD INFUSED PRODUCTS MADE FROM COLORADO-GROWN ORGANIC HEMP
CBD USER GUIDE CUREDNUTRITION.COM CBD INFUSED PRODUCTS MADE FROM COLORADO-GROWN ORGANIC HEMP table of contents All about CBD What are Cannabinoids What is CBD? How is CBD different from THC? The Endocannabinoid
More informationLegalized Marijuana: Uses, Misuses & Abuses. Disclosures. Objectives. Kennon Heard University of Colorado SOM Dept Of Emergency Medicine
Legalized Marijuana: Uses, Misuses & Abuses Kennon Heard University of Colorado SOM Dept Of Emergency Medicine Disclosures Research grants McNeil Consumer Healthcare (Acetaminophen) Rare Disease Therapeutics
More informationClinical Education Initiative MEDICAL MARIJUANA 101. Speaker: Patricia Reed, PharmD
Clinical Education Initiative Support@ceitraining.org MEDICAL MARIJUANA 101 Speaker: Patricia Reed, PharmD 8/2/2017 Medical Marijuana 101 [video transcript] 00:00:12 - So we'll get started. Disclosures
More informationResearch: Medical Cannabis
Research: Medical Cannabis Background The hemp plant Cannabis sativa (cannabis) is commonly known as marijuana and can be used as a therapy to alleviate symptoms such as pain and fatigue caused by chronic
More informationMedical Marijuana Martin P. Eason MD, JD Associate Chief of Staff for Education Mountain Home VA Medical Center. Disclosure.
Medical Marijuana Martin P. Eason MD, JD Associate Chief of Staff for Education Mountain Home VA Medical Center Controversies in Pain Management Conference Johnson City, TN November 13, 2015 Disclosure
More informationAnalytical Testing and Quality Assurance for Cannabis
Analytical Testing and Quality Assurance for Cannabis Anthony Smith, Ph.D Kenevir Research, 2016 Analytical Testing and Quality Assurance for Cannabis 1. Cannabis is a complex matrix 2. What is the role
More informationInvestigational Pharmacy Cannabidiol treatment in Epilepsy
Jon Beck BS Pharm D Coordinator Investigational Pharmacy Disclosure I have no relevant financial relationships with a Commercial Provider Nebraska Medicine Omaha, NE Investigational Pharmacy Cannabidiol
More informationCannabis Processing For Thc Cbd Terpenes
We have made it easy for you to find a PDF Ebooks without any digging. And by having access to our ebooks online or by storing it on your computer, you have convenient answers with cannabis processing
More informationThe Determination of CBD and General Cannabinoid Content in Hemp Oils Using HPLC with UV Detection
High Performance Liquid Chromatography No. HPLC-018 The Determination of CBD and General Cannabinoid Content in Hemp Oils Using HPLC with UV Detection Introduction Medical marijuana generally possesses
More informationJames Donaldson CEO and Executive Director
Welcome! James Donaldson CEO and Executive Director Dr. Natasha Ryz Chief Science Officer, Zenabis Cannabis 101 Introduction to Cannabis Plant Cannabis is a genus of flowering plants within the family
More informationDr. Hagit Marchaim, Regulatory Affairs & Drug Development Consulting - HMC
Dr. Hagit Marchaim, Regulatory Affairs & Drug Development Consulting - HMC 1 Disclosures I (Dr. Hagit Marchaim) have no financial relationships to disclose concerning the content of this presentation or
More informationWHO Expert Committee on Drug Dependence Pre-Review: Extracts and tinctures of cannabis. Expert Peer Review 2
WHO Expert Committee on Drug Dependence Pre-Review: Extracts and tinctures of cannabis Expert Peer Review 2 1. Comments based on the review report a. Evidence on dependence and abuse potential Extracts
More informationThe Effects known & unknown of Marijuana in Older Adults. Danielle Fixen, PharmD, BCGP, BCPS University of Colorado School of Pharmacy
The Effects known & unknown of Marijuana in Older Adults Danielle Fixen, PharmD, BCGP, BCPS University of Colorado School of Pharmacy Learning Objectives 1. Review various dosing strategies for medical
More informationBDS ANALYTICS Top Ten Cannabis Market Trends for 2019
BDS ANALYTICS Top Ten Cannabis Market Trends for 2019 Presented by: Roy Bingham CEO and Co-Founder roy@bdsanalytics.com Jessica Lukas VP, Consumer Insights Jessica@bdsanalytics.com 2018 PREDICTIONS https://bdsanalytics.com/bds-analytics-top-10-cannabis-market-trends-2018/
More informationBrian C. Smith, Ph.D. Chief Technical Officer Big Sur Scientific (508)
Measurement of Cannabinoid and Terpene Profiles in Cannabis Extracts by Mid-Infrared Spectroscopy Brian C. Smith, Ph.D. Chief Technical Officer Big Sur Scientific Brian@bigsurscientific.com (508) 579-6514
More information4/15/2019. US States with Marijuana Laws in Have ACOG and SMFM taken notice? THE EFFECTS OF MARIJUANA USE ON PREGNANCY AND LACTATION
THE EFFECTS OF MARIJUANA USE ON PREGNANCY AND LACTATION Susan R Davidson, MD Maternal Fetal Medicine Department of Ob/Gyn St. Mary s Hospital Madison, WI SSM Health I HAVE NO FINANCIAL DISCLOSURES TO REPORT
More informationCannabis derived terpenes for sale
Cannabis derived terpenes for sale Buy real weed online! Your premium edibles. Cannabis Oil. Canabidol CBD cannabis oil (CBD Oli) is derived from EU approved, UK & US legal, industrial hemp (Cannabis Sativa
More informationImproving The Quality And Efficiency Of Terpene Extraction From Cannabis Plant
Tech Note Improving The Quality And Efficiency Of Terpene Extraction From Cannabis Plant Highly efficient microwave processing of terpenes with the Milestone ETHOS X Introduction As the cannabis industry
More informationSwissmedic Approval Options and Limits. Swiss Task Force for Cannabinoids in Medicine Conference November 12, 2016
Swissmedic Approval Options and Limits Swiss Task Force for Cannabinoids in Medicine Conference November 12, 2016 Cannabis Ordinance on the lists of narcotics, psychotropic substances, precursors and auxiliary
More informationOrganic All of our plants are grown using organic farming principles. We feed the soil so the soil can feed the plants.
Organic All of our plants are grown using organic farming principles. We feed the soil so the soil can feed the plants. U.S. Produced All of our plants are grown in the USA and represent cannabinoid rich
More informationSusan Allen-Evenson Hosts: Laura Lagano, MS, RDN, CDN Prepare for the Next Level: Incorporating Holistic Cannabis in the Nutrition Practice
Susan Allen-Evenson Hosts: Laura Lagano, MS, RDN, CDN Prepare for the Next Level: Incorporating Holistic Cannabis in the Nutrition Practice Integrative Clinical Nutritionist, Laura Lagano MS, RDN, CDN
More informationMarijuana for Medical Use Patient Information
Marijuana for Medical Use Patient Information Marijuana for Medical Use Patient Information Table of Contents Page A. Marijuana (Cannabis) Strains... 3 B. Cannabinoids... 3 C. Routes of Administration...
More informationFor both people and animals, medicine
CBD & Dogs: A Primer By The Bark Editors QUESTIONS 58 / LAW 59 / VETERINARIAN 60 / BUYING 61 / TAKEAWAYS 62 / GLOSSARY 63 For both people and animals, medicine tends to trend high-tech. One of the most
More informationAct 16 and Medical Cannabis in Pennsylvania
Act 16 and Medical Cannabis in Pennsylvania Charles V. Pollack, Jr., MA, MD, FACEP, FAAEM, FAHA, FESC, FCPP Associate Provost and Professor of Emergency Medicine Director, Institute of Emerging Health
More informationMedical Marijuana: The Move to Schedule II
Medical Marijuana: The Move to Schedule II David Deitz, MD, PhD David Deitz & Associates Today s discussion Does medical marijuana actually treat anything? What are the workplace issues? What are the interactions
More informationMedicinal cannabis. What is medicinal cannabis? What are cannabinoids? The endocannabinoid system
Medicinal cannabis What is medicinal cannabis? Broadly speaking, medicinal cannabis is cannabis prescribed to relieve the symptoms of a medical condition, such as epilepsy. It is important to make the
More informationCerti cate of Analysis
Powered by 1 of 8 Dear Valued Colleague, Thank you for selecting C4 Laboratories. Our goal at C4 is to provide reliable data that is interpreted within the appropriate physiological context, to ultimately
More informationDR. STUART TITUS Co-Founder and President of Medical Marijuana, Inc.
TM DR. STUART TITUS Co-Founder and President of Medical Marijuana, Inc. STUART TITUS Co-Founder and President of Medical Marijuana, Inc. Stuart began his association with our family of companies in 2008,
More informationCerti cate of Analysis
1 of 8 Dear Valued Colleague, Thank you for selecting C4 Laboratories. Our goal at C4 is to provide reliable data that is interpreted within the appropriate physiological context, to ultimately empower
More informationAnti-inflammatory Cannabinoids without psycho-active side-effects
Anti-inflammatory Cannabinoids without psycho-active side-effects Opportunities for further development to a drug formulation Introduction More than 5000 years ago, the Chinese already used Cannabis for
More informationCDHA 2016 Fall Symposium. Speaker Handout Files. For registered attendees only
CDHA 2016 Fall Symposium Speaker Handout Files For registered attendees only Providing Care in a Marijuana Legal World Heather Rogers, BSDH heatherrdh@heatherrdh.com Objectives We will discuss some of
More informationCerti cate of Analysis
1 of 8 Dear Valued Colleague, Thank you for selecting C4 Laboratories. Our goal at C4 is to provide reliable data that is interpreted within the appropriate physiological context, to ultimately empower
More informationCannabis: Therapeutic properties of the plant
Cannabis: Therapeutic properties of the plant Medicinal cannabis is still illegal to be used in South Africa. In a victory for marijuana users across South Africa, ConCourt has officially legalised cannabis
More informationCerti cate of Analysis
1 of 8 Dear Valued Colleague, Thank you for selecting C4 Laboratories. Our goal at C4 is to provide reliable data that is interpreted within the appropriate physiological context, to ultimately empower
More informationCerti cate of Analysis
1 of 8 Dear Valued Colleague, Thank you for selecting C4 Laboratories. Our goal at C4 is to provide reliable data that is interpreted within the appropriate physiological context, to ultimately empower
More information9/28/2015. Support. R01CA A1 Intervening with smoking parents of inpatients to reduce
Medical marijuana and the impact of marijuana policy on children Karen M. Wilson, MD, MPH, FAAP Associate Professor of Pediatrics Section Head, Pediatric Hospital Medicine University of Colorado School
More informationCoalition for Medical Marijuana Research & Education
Coalition for Medical Marijuana Research & Education Nagi Kumar, Ph.D., R.D., FADA Professor, Oncologic Sciences Director, Cancer Chemoprevention Executive Director, Coalition for Medical Marijuana Research
More information12025 NE Marx St. Portland, OR Green Leaf Lab proudly follows / ISO/IEC 17025:2005(E) Quality Standards
Mango Sample ID S126645 Matrix: Flower Potency via GC-MS / GC-FID HP 5890 / HP 5972 Total THC (Δ8+Δ9) 16.76 17.62 8-THC 0.24 0.26 9-THC 16.52 17.37 CBD 0.15 0.15 CBN 0.37 0.39 CBG 0.80 0.84 0.24% CBC 0.20
More informationCerti cate of Analysis
Powered by 1 of 8 Strain: Dear Valued Colleague, Thank you for selecting C4 Laboratories. Our goal at C4 is to provide reliable data that is interpreted within the appropriate physiological context, to
More informationCerti cate of Analysis
Powered by 1 of 8 Strain: Dear Valued Colleague, Thank you for selecting C4 Laboratories. Our goal at C4 is to provide reliable data that is interpreted within the appropriate physiological context, to
More informationLoveland Molecular Laboratories
Loveland Molecular Laboratories Clean All of our extracts are produced in our state-of-the-art laboratory and are free of any residual solvents for the purest oil possible. Consistent We use the right
More information